CN111228163A - Halitosis-resisting toothpaste and preparation method thereof - Google Patents
Halitosis-resisting toothpaste and preparation method thereof Download PDFInfo
- Publication number
- CN111228163A CN111228163A CN201910874009.8A CN201910874009A CN111228163A CN 111228163 A CN111228163 A CN 111228163A CN 201910874009 A CN201910874009 A CN 201910874009A CN 111228163 A CN111228163 A CN 111228163A
- Authority
- CN
- China
- Prior art keywords
- parts
- mass ratio
- toothpaste
- sodium sulfate
- halitosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses halitosis-resisting toothpaste and a preparation method thereof, and belongs to the technical field of toothpaste manufacture. The raw materials of the anti-halitosis toothpaste comprise the following components: 40-50 parts of toothpaste base material, 10-20 parts of pummelo peel, 10-20 parts of liquorice and 5-10 parts of wormwood; the preparation method of the halitosis-resisting toothpaste comprises the steps of picking and cleaning pummelo peel, liquorice and wormwood, drying at low temperature, crushing, adding pure water for dissolving, adding toothpaste base materials, heating while stirring, and finally carrying out vacuum degassing and grinding. The halitosis-resisting toothpaste prepared by the invention utilizes the synergistic interaction among various Chinese herbal medicines, effectively exerts the active ingredients of the medicines by a proper preparation method, and has good and lasting halitosis-removing effect.
Description
Technical Field
The invention belongs to the technical field of toothpaste manufacturing, and particularly relates to halitosis-resisting toothpaste and a preparation method thereof.
Background
Halitosis refers to odor emitted from the oral cavity or other air-filled cavities such as the nose, the sinuses and the pharynx, which seriously affects social interaction and mental health of people, and the investigation shows that the prevalence rate of halitosis in China is 27.5%. And 50% in western countries. About 10% to 65% of people worldwide have had halitosis.
The halitosis has great harm to the life of people, causes harm to the psychology of the patients, seriously affects the self-esteem of the patients, and seriously destroys the healthy environment in the oral cavity, so that a large amount of bacteria and fungi are remained in the oral cavity, causing great harm to the human body, and the halitosis causes the bitter taste and the dry mouth in the oral cavity, and greatly affects the appetite.
In the aspect of traditional Chinese medicines for treating halitosis, mint, liquorice, rhubarb, dried orange peel, jasmine, chrysanthemum, sweet osmanthus and the like have the effect of treating halitosis. The traditional Chinese medicines can relieve the problem of halitosis to a certain extent, but the traditional Chinese medicines capable of effectively curing halitosis for a long time are still few.
Disclosure of Invention
1. Problems to be solved
Aiming at the problems of the existing halitosis-resisting toothpaste, the invention provides halitosis-resisting toothpaste and a preparation method thereof, which utilize the synergistic interaction among a plurality of Chinese herbal medicines and enable the active ingredients of the medicines to be effectively exerted through a proper preparation method, and have good and lasting halitosis-removing effect.
2. Technical scheme
In order to solve the above problems, the present invention adopts the following technical solutions.
The halitosis-resisting toothpaste comprises the following raw materials in parts by weight:
40-50 parts of toothpaste base material, 10-20 parts of pummelo peel, 10-20 parts of liquorice and 5-10 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
in the anti-halitosis toothpaste, the anti-halitosis toothpaste comprises the following raw materials in parts by weight:
40 parts of toothpaste base material, 20 parts of pummelo peel, 10 parts of liquorice and 10 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
the halitosis-resisting toothpaste comprises the following raw materials in parts by weight:
50 parts of toothpaste base material, 10 parts of pummelo peel, 20 parts of liquorice and 5 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
the halitosis-resisting toothpaste comprises the following raw materials in parts by weight:
43 parts of toothpaste base material, 18 parts of pummelo peel, 12 parts of liquorice and 9 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
the halitosis-resisting toothpaste comprises the following raw materials in parts by weight:
48 parts of toothpaste base material, 12 parts of pummelo peel, 17 parts of liquorice and 6 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
the halitosis-resisting toothpaste comprises the following raw materials in parts by weight:
45 parts of toothpaste base material, 15 parts of pummelo peel, 15 parts of liquorice and 7 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
a preparation method of an anti-halitosis toothpaste comprises the following steps:
(1) picking and cleaning exocarpium Citri Grandis, Glycyrrhrizae radix and folium Artemisiae Argyi;
(2) drying the pummelo peel, the liquorice and the wormwood treated in the step (1) at a low temperature, and then crushing to prepare dry powder;
(3) adding pure water into the dry powder prepared in the step (2) for dissolving to prepare suspension;
(4) adding the toothpaste base material into the suspension prepared in the step (3), and heating while stirring to prepare paste liquid;
(5) and (4) carrying out vacuum degassing on the paste prepared in the step (4) and grinding to obtain the toothpaste.
In the preparation method of the halitosis-resisting toothpaste, the temperature for drying at the low temperature in the step (2) is 20 ℃.
In the preparation method of the anti-halitosis toothpaste, the heating temperature in the step (4) is 37 ℃.
In the preparation method of the anti-halitosis toothpaste, the vacuum degree of vacuum degassing in the step (5) is-0.25 MPa to-0.005 MPa.
3. Advantageous effects
Compared with the prior art, the invention has the beneficial effects that:
the halitosis-resisting toothpaste disclosed by the invention utilizes the synergistic interaction among various Chinese herbal medicines, effectively exerts the active ingredients of the medicines through a proper preparation method, and has a good and lasting halitosis-removing effect.
Detailed Description
The invention is further described with reference to specific examples.
Example 1
The anti-halitosis toothpaste comprises the following raw materials in parts by weight:
40 parts of toothpaste base material, 20 parts of pummelo peel, 10 parts of liquorice and 10 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
the preparation method of the halitosis-resisting toothpaste comprises the following steps:
(1) picking and cleaning exocarpium Citri Grandis, Glycyrrhrizae radix and folium Artemisiae Argyi;
(2) drying the pummelo peel, the liquorice and the wormwood treated in the step (1) at a low temperature, and then crushing to prepare dry powder; wherein the low-temperature drying temperature is 20 ℃;
(3) adding pure water into the dry powder prepared in the step (2) for dissolving to prepare suspension;
(4) adding the toothpaste base material into the suspension prepared in the step (3), and heating while stirring to prepare paste liquid; wherein the heating temperature is 37 ℃;
(5) vacuum degassing and grinding the paste prepared in the step (4) to obtain the paste; the vacuum degree of vacuum degassing is-0.25 MPa.
Example 2
The anti-halitosis toothpaste comprises the following raw materials in parts by weight:
50 parts of toothpaste base material, 10 parts of pummelo peel, 20 parts of liquorice and 5 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
the preparation method of the halitosis-resisting toothpaste comprises the following steps:
(1) picking and cleaning exocarpium Citri Grandis, Glycyrrhrizae radix and folium Artemisiae Argyi;
(2) drying the pummelo peel, the liquorice and the wormwood treated in the step (1) at a low temperature, and then crushing to prepare dry powder; wherein the low-temperature drying temperature is 20 ℃;
(3) adding pure water into the dry powder prepared in the step (2) for dissolving to prepare suspension;
(4) adding the toothpaste base material into the suspension prepared in the step (3), and heating while stirring to prepare paste liquid; wherein the heating temperature is 37 ℃;
(5) vacuum degassing and grinding the paste prepared in the step (4) to obtain the paste; the vacuum degree of vacuum degassing is-0.005 MPa.
Example 3
The anti-halitosis toothpaste comprises the following raw materials in parts by weight:
43 parts of toothpaste base material, 18 parts of pummelo peel, 12 parts of liquorice and 9 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
the preparation method of the halitosis-resisting toothpaste comprises the following steps:
(1) picking and cleaning exocarpium Citri Grandis, Glycyrrhrizae radix and folium Artemisiae Argyi;
(2) drying the pummelo peel, the liquorice and the wormwood treated in the step (1) at a low temperature, and then crushing to prepare dry powder; wherein the low-temperature drying temperature is 20 ℃;
(3) adding pure water into the dry powder prepared in the step (2) for dissolving to prepare suspension;
(4) adding the toothpaste base material into the suspension prepared in the step (3), and heating while stirring to prepare paste liquid; wherein the heating temperature is 37 ℃;
(5) vacuum degassing and grinding the paste prepared in the step (4) to obtain the paste; the vacuum degree of vacuum degassing is-0.005 MPa.
Example 4
The anti-halitosis toothpaste comprises the following raw materials in parts by weight:
48 parts of toothpaste base material, 12 parts of pummelo peel, 17 parts of liquorice and 6 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
the preparation method of the halitosis-resisting toothpaste comprises the following steps:
(1) picking and cleaning exocarpium Citri Grandis, Glycyrrhrizae radix and folium Artemisiae Argyi;
(2) drying the pummelo peel, the liquorice and the wormwood treated in the step (1) at a low temperature, and then crushing to prepare dry powder; wherein the low-temperature drying temperature is 20 ℃;
(3) adding pure water into the dry powder prepared in the step (2) for dissolving to prepare suspension;
(4) adding the toothpaste base material into the suspension prepared in the step (3), and heating while stirring to prepare paste liquid; wherein the heating temperature is 37 ℃;
(5) vacuum degassing and grinding the paste prepared in the step (4) to obtain the paste; the vacuum degree of vacuum degassing is-0.005 MPa.
Example 5
The anti-halitosis toothpaste comprises the following raw materials in parts by weight:
45 parts of toothpaste base material, 15 parts of pummelo peel, 15 parts of liquorice and 7 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
the preparation method of the halitosis-resisting toothpaste comprises the following steps:
(1) picking and cleaning exocarpium Citri Grandis, Glycyrrhrizae radix and folium Artemisiae Argyi;
(2) drying the pummelo peel, the liquorice and the wormwood treated in the step (1) at a low temperature, and then crushing to prepare dry powder; wherein the low-temperature drying temperature is 20 ℃;
(3) adding pure water into the dry powder prepared in the step (2) for dissolving to prepare suspension;
(4) adding the toothpaste base material into the suspension prepared in the step (3), and heating while stirring to prepare paste liquid; wherein the heating temperature is 37 ℃;
(5) vacuum degassing and grinding the paste prepared in the step (4) to obtain the paste; the vacuum degree of vacuum degassing is-0.25 MPa.
Comparative example 1
The anti-halitosis toothpaste comprises the following raw materials in parts by weight:
45 parts of toothpaste base material, 15 parts of liquorice and 7 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
the preparation method of the halitosis-resisting toothpaste comprises the following steps:
(1) picking and cleaning liquorice and wormwood;
(2) drying the liquorice and the wormwood processed in the step (1) at a low temperature, and then crushing to prepare dry powder; wherein the low-temperature drying temperature is 20 ℃;
(3) adding pure water into the dry powder prepared in the step (2) for dissolving to prepare suspension;
(4) adding the toothpaste base material into the suspension prepared in the step (3), and heating while stirring to prepare paste liquid; wherein the heating temperature is 37 ℃;
(5) vacuum degassing and grinding the paste prepared in the step (4) to obtain the paste; the vacuum degree of vacuum degassing is-0.25 MPa.
Comparative example 2
The anti-halitosis toothpaste comprises the following raw materials in parts by weight:
45 parts of toothpaste base material, 15 parts of pummelo peel and 7 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
the preparation method of the halitosis-resisting toothpaste comprises the following steps:
(1) picking and cleaning exocarpium Citri Grandis and folium Artemisiae Argyi;
(2) drying the pummelo peel, the liquorice and the wormwood treated in the step (1) at a low temperature, and then crushing to prepare dry powder; wherein the low-temperature drying temperature is 20 ℃;
(3) adding pure water into the dry powder prepared in the step (2) for dissolving to prepare suspension;
(4) adding the toothpaste base material into the suspension prepared in the step (3), and heating while stirring to prepare paste liquid; wherein the heating temperature is 37 ℃;
(5) vacuum degassing and grinding the paste prepared in the step (4) to obtain the paste; the vacuum degree of vacuum degassing is-0.25 MPa.
Comparative example 3
The anti-halitosis toothpaste comprises the following raw materials in parts by weight:
45 parts of toothpaste base material, 15 parts of pummelo peel and 15 parts of liquorice;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
the preparation method of the halitosis-resisting toothpaste comprises the following steps:
(1) picking and cleaning pummelo peel and liquorice;
(2) drying the pummelo peel and the liquorice treated in the step (1) at a low temperature, and then crushing to prepare dry powder; wherein the low-temperature drying temperature is 20 ℃;
(3) adding pure water into the dry powder prepared in the step (2) for dissolving to prepare suspension;
(4) adding the toothpaste base material into the suspension prepared in the step (3), and heating while stirring to prepare paste liquid; wherein the heating temperature is 37 ℃;
(5) vacuum degassing and grinding the paste prepared in the step (4) to obtain the paste; the vacuum degree of vacuum degassing is-0.25 MPa.
Example 6
Test for Effect on pathogenic bacteria of halitosis
(1) In vitro inhibition of halitosis pathogens:
the inhibition effect of the anti-halitosis toothpaste of the invention on the salivary anaerobe of the halitosis patients is determined by an in-vitro drug sensitivity test, and the growth inhibition of the anti-halitosis toothpaste of the invention on the Fusobacterium nucleatum standard strain (ATCC 25586) and the Streptococcus mutans standard strain (ATCC 25175) is observed.
The average inhibition percentage of the halitosis-resisting toothpaste (examples 1-5) of the invention to salivary anaerobes of halitosis patients is 65%, the average inhibition percentage of the halitosis-resisting toothpaste to fusobacterium nucleatum is 96%, and the average inhibition percentage of the halitosis-resisting toothpaste to streptococcus mutans is 97%. While the average percent inhibition of the anti-halitosis toothpastes of comparative examples 1-3 against salivary anaerobes of halitosis patients was only 35%, the average percent inhibition against Fusobacterium nucleatum was 46%, and the average percent inhibition against Streptococcus mutans was 25%.
(2) The inhibition effect on Volatile Sulfides (VSCs) produced by halitosis pathogenic bacteria:
the anti-halitosis toothpaste of the present invention (examples 1-5) has a significant and good inhibitory effect against volatile sulfide gas production by halitosis-causing bacteria, compared to the corresponding toothpastes of comparative examples 1-3, the average value (ppb) of the VSCs of the present invention is 923, the average inhibitory rate is 67%, and the average value (ppb) of the VSCs of comparative examples 1-3 is up to 1345, and the average inhibitory rate is only 31%.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (10)
1. An anti-halitosis toothpaste, which is characterized in that: the raw materials comprise the following components in parts by weight:
40-50 parts of toothpaste base material, 10-20 parts of pummelo peel, 10-20 parts of liquorice and 5-10 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
2. an anti-halitosis toothpaste according to claim 1, wherein: the halitosis-resisting toothpaste comprises the following raw materials in parts by weight:
40 parts of toothpaste base material, 20 parts of pummelo peel, 10 parts of liquorice and 10 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
3. an anti-halitosis toothpaste according to claim 1, wherein: the halitosis-resisting toothpaste comprises the following raw materials in parts by weight:
50 parts of toothpaste base material, 10 parts of pummelo peel, 20 parts of liquorice and 5 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
4. an anti-halitosis toothpaste according to claim 1, wherein: the halitosis-resisting toothpaste comprises the following raw materials in parts by weight:
43 parts of toothpaste base material, 18 parts of pummelo peel, 12 parts of liquorice and 9 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
5. an anti-halitosis toothpaste according to claim 1, wherein: the halitosis-resisting toothpaste comprises the following raw materials in parts by weight:
48 parts of toothpaste base material, 12 parts of pummelo peel, 17 parts of liquorice and 6 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
6. an anti-halitosis toothpaste according to claim 1, wherein: the halitosis-resisting toothpaste comprises the following raw materials in parts by weight:
45 parts of toothpaste base material, 15 parts of pummelo peel, 15 parts of liquorice and 7 parts of wormwood;
the toothpaste base material comprises an abrasive, a humectant, a surfactant and a thickener, wherein the mass ratio of the abrasive to the humectant to the surfactant to the thickener is 2: 1: 2: 1,
wherein the friction agent is a mixture of calcium carbonate and silicon dioxide, and the mass ratio of the calcium carbonate to the silicon dioxide is 1: 1,
the humectant is a mixture of propylene glycol, xylitol and polyethylene glycol, and the mass ratio of the propylene glycol to the xylitol to the polyethylene glycol is 1: 2: 1,
wherein the surfactant is a mixture of fatty alcohol-polyoxyethylene ether sodium sulfate and lauryl alcohol sodium sulfate, and the mass ratio of the fatty alcohol-polyoxyethylene ether sodium sulfate to the lauryl alcohol sodium sulfate is 2: 1,
wherein the thickening agent is carboxymethyl cellulose and xanthan gum, and the mass ratio of the carboxymethyl cellulose to the xanthan gum is 1: 2.
7. a preparation method of an anti-halitosis toothpaste comprises the following steps:
(1) picking and cleaning exocarpium Citri Grandis, Glycyrrhrizae radix and folium Artemisiae Argyi;
(2) drying the pummelo peel, the liquorice and the wormwood treated in the step (1) at a low temperature, and then crushing to prepare dry powder;
(3) adding pure water into the dry powder prepared in the step (2) for dissolving to prepare suspension;
(4) adding the toothpaste base material into the suspension prepared in the step (3), and heating while stirring to prepare paste liquid;
(5) and (4) carrying out vacuum degassing on the paste prepared in the step (4) and grinding to obtain the toothpaste.
8. The method for preparing an anti-halitosis toothpaste according to claim 6, wherein:
the temperature for drying at low temperature in the step (2) is 20 ℃.
9. The method for preparing an anti-halitosis toothpaste according to claim 6, wherein:
the temperature of heating in step (4) was 37 ℃.
10. The method for preparing an anti-halitosis toothpaste according to claim 6, wherein:
the vacuum degree of vacuum degassing in the step (5) is-0.25 MPa to-0.005 MPa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910874009.8A CN111228163A (en) | 2019-09-17 | 2019-09-17 | Halitosis-resisting toothpaste and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910874009.8A CN111228163A (en) | 2019-09-17 | 2019-09-17 | Halitosis-resisting toothpaste and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111228163A true CN111228163A (en) | 2020-06-05 |
Family
ID=70863402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910874009.8A Pending CN111228163A (en) | 2019-09-17 | 2019-09-17 | Halitosis-resisting toothpaste and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111228163A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115487105A (en) * | 2021-12-07 | 2022-12-20 | 象记(上海)生物科技有限公司 | Chinese herbal medicine toothpaste capable of refreshing breath and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130100447A (en) * | 2012-03-02 | 2013-09-11 | 어수옥 | Toothpaste containing medicinal herbs |
| CN104173253A (en) * | 2014-08-08 | 2014-12-03 | 侨健新能源科技（苏州）有限公司 | Children toothpaste for preventing decayed teeth |
| CN104940086A (en) * | 2015-07-13 | 2015-09-30 | 李丽芬 | Chinese herbal toothpaste capable of diminishing inflammation and eliminating halitosis |
| CN107519071A (en) * | 2017-08-12 | 2017-12-29 | 安徽楚艾农业科技有限公司 | A kind of wormwood toothpaste of anti-inflammation and preparation method thereof |
| CN107638366A (en) * | 2017-10-19 | 2018-01-30 | 广西民族大学 | A kind of wormwood aloe toothpaste |
-
2019
- 2019-09-17 CN CN201910874009.8A patent/CN111228163A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130100447A (en) * | 2012-03-02 | 2013-09-11 | 어수옥 | Toothpaste containing medicinal herbs |
| CN104173253A (en) * | 2014-08-08 | 2014-12-03 | 侨健新能源科技（苏州）有限公司 | Children toothpaste for preventing decayed teeth |
| CN104940086A (en) * | 2015-07-13 | 2015-09-30 | 李丽芬 | Chinese herbal toothpaste capable of diminishing inflammation and eliminating halitosis |
| CN107519071A (en) * | 2017-08-12 | 2017-12-29 | 安徽楚艾农业科技有限公司 | A kind of wormwood toothpaste of anti-inflammation and preparation method thereof |
| CN107638366A (en) * | 2017-10-19 | 2018-01-30 | 广西民族大学 | A kind of wormwood aloe toothpaste |
Non-Patent Citations (1)
| Title |
|---|
| （加）塞萨尔丁•阿拉萨尔瓦，法瑞东•萨和迪: "《干果的植物化学成分及其保健作用》", vol. 1, 中国医药科技出版社, pages: 299 - 288 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115487105A (en) * | 2021-12-07 | 2022-12-20 | 象记(上海)生物科技有限公司 | Chinese herbal medicine toothpaste capable of refreshing breath and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104207982B (en) | Prevent Chinese medicine composition and the oral care product containing it that oral cavity is got angry | |
| CN108042466A (en) | A kind of anti-inflammatory sterilization, the oral care composition of prevention and treatment dental caries | |
| CN109010471A (en) | A kind of antibacterial anti-inflammatory Chinese medicine composition and its preparing the application in oral care product | |
| CN106619269A (en) | Antiphlogosis antiallergic mouthwash and preparation method thereof | |
| CN105232431A (en) | Antibacterial gingival-protecting high-efficiency toothpaste with specific component of modified traditional Chinese herbal medicine and preparation method of antibacterial gingival-protecting high-efficiency toothpaste | |
| CN105030601A (en) | Taxus chinensis healthcare toothpaste and preparation method thereof | |
| CN110559253A (en) | toothpaste added with probiotics for resisting oral bacteria and preparation method thereof | |
| CN111228163A (en) | Halitosis-resisting toothpaste and preparation method thereof | |
| CN105663014A (en) | Inflammation diminishing and whitening toothpaste containing rhizoma coptidis and fresh ginger | |
| KR102324554B1 (en) | Jelly Toothpaste and Manufacturing Method of thereof | |
| US20160303035A1 (en) | Toothpaste Composition Containing Curcuma Longa L. and Method of Manufacturing Same | |
| CN113616721A (en) | Pharmaceutical composition for treating oral ulcer and preparation method and application thereof | |
| CN105748356B (en) | A kind of compound Artemisia rupestris bitter taste toothpaste | |
| CN106377481B (en) | A method for extracting rhizoma Cyperi extract, and toothpaste and collutory containing the same | |
| CN106474011A (en) | A kind of toothpaste and preparation method thereof | |
| CN103655301B (en) | A kind of toothpaste containing Herba Achilleae extract and preparation method thereof | |
| CN109381350A (en) | One kind toothpaste containing polygonum cuspidate and preparation method thereof | |
| CN109394903B (en) | Oral care composition taking borneol cinnamomum camphora as monarch drug | |
| CN106821902A (en) | A kind of Chinese medicinal toothpaste | |
| CN107308213A (en) | A kind of fig effervescent tablet and its production method | |
| KR101599767B1 (en) | A toothpaste composition comprising non-toxic mineral sulfur and a method for preparation thereof | |
| CN112336653A (en) | Cold algae functional toothpaste and preparation method thereof | |
| CN103751054B (en) | A kind of forsythia suspense leaf gargle and preparation method thereof | |
| CN108524404A (en) | A kind of sealwort herbaceous toothpaste | |
| CN114712415B (en) | Radix scutellariae, honeysuckle and pseudo-ginseng composition with functions of repairing dental ulcer and stopping bleeding |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |