CN115487105A - Chinese herbal medicine toothpaste capable of refreshing breath and preparation method thereof - Google Patents
Chinese herbal medicine toothpaste capable of refreshing breath and preparation method thereof Download PDFInfo
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- CN115487105A CN115487105A CN202111489213.1A CN202111489213A CN115487105A CN 115487105 A CN115487105 A CN 115487105A CN 202111489213 A CN202111489213 A CN 202111489213A CN 115487105 A CN115487105 A CN 115487105A
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- toothpaste
- preservative
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- 206010022437 insomnia Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
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- PVGBHEUCHKGFQP-UHFFFAOYSA-N sodium;n-[5-amino-2-(4-aminophenyl)sulfonylphenyl]sulfonylacetamide Chemical compound [Na+].CC(=O)NS(=O)(=O)C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 PVGBHEUCHKGFQP-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Cosmetics (AREA)
Abstract
The invention relates to the field of toothpaste, the IPC classification number is A61K 8/9, and in particular relates to a Chinese herbal medicine toothpaste capable of freshening breath and a preparation method thereof. The preparation raw materials of the Chinese herbal medicine toothpaste for freshening breath comprise the following components in parts by weight: 34-75 parts of traditional Chinese medicine extract, 2-7 parts of an abrasive, 5-10 parts of a humectant, 3-10 parts of a surfactant, 0.5-1 part of a thickening agent, 0.5-1 part of a preservative and 0.3-1 part of a pH regulator. The preparation method comprises the steps of mixing the traditional Chinese medicine extract, water and the humectant, placing the mixture into an ointment preparation tank, stirring and mixing, adding the abrasive, the thickening agent, the preservative and the pH regulator, mixing, and finally adding the surfactant for homogenization to prepare the Chinese herbal medicine toothpaste which can help smokers to refresh breath for a long time, wherein the Chinese herbal medicine toothpaste has excellent stability and strong cleaning power.
Description
Technical Field
The invention relates to the field of toothpaste, the IPC classification number is A61K 8/9, and in particular relates to a Chinese herbal medicine toothpaste capable of freshening breath and a preparation method thereof.
Background
In the early days, people mostly use calcium carbonate as an abrasive and soap as a surfactant to prepare tooth powder to clean dental plaque and food residues, remove peculiar smell in the oral cavity and keep the oral cavity clean, and people rub the traditional Chinese medicine powder into the teeth and use medicines to inhibit bacteria in the oral cavity so as to meet the requirements of beautifying the teeth and protecting the oral cavity health.
In recent years, toothpaste has been developed from a common tooth cleaning function to an additive medicine to become an oral hygiene product for preventing and treating dental diseases, and the incidence rate of dental caries can be greatly reduced by adding stannous fluoride into toothpaste taking calcium pyrophosphate as an abrasive and tin pyrophosphate as a stabilizing agent.
Patent CN108403496A discloses a Chinese herbal medicine toothpaste with hemostatic, anti-inflammatory and antibacterial effects and a preparation process thereof, wherein the preparation raw materials include pseudo-ginseng, scutellaria baicalensis, honeysuckle, orange peel essential oil, sorbitol, silicone oil and the like, and the toothpaste has the hemostatic, anti-inflammatory and antibacterial effects, but the ingredient of the toothpaste contains the silicone oil to influence the taste of the toothpaste.
Patent CN105534797A discloses a hemostatic and antibacterial Chinese herbal toothpaste, which comprises Chinese herbal medicines, adjuvant, and deionized water antiseptic, and has hemostatic, antibacterial, anti-inflammatory, and analgesic effects, but the antiseptic is methyl paraben, and has certain irritation to oral cavity.
Disclosure of Invention
In order to solve the above problems, the first aspect of the present invention provides a breath freshening Chinese herbal medicine toothpaste, which comprises the following raw materials by weight: 34-75 parts of traditional Chinese medicine extract, 2-7 parts of an abrasive, 5-10 parts of a humectant, 3-10 parts of a surfactant, 0.5-1 part of a thickening agent, 0.5-1 part of a preservative and 0.3-1 part of a pH regulator.
As a preferable technical scheme, the traditional Chinese medicine extract comprises the following preparation raw materials in parts by weight: 2-5 parts of wormwood, 5-10 parts of polygala tenuifolia, 5-10 parts of liquorice, 2-5 parts of ganoderma lucidum, 2-5 parts of cablin potchouli herb, 2-10 parts of mint, 3-5 parts of sea salt, 3-5 parts of bamboo leaf, 5-10 parts of pseudo-ginseng and 5-10 parts of Perilla frutescens, wherein the wormwood is dry leaves of Artemisia argyi Levl. Et Vat. Of Compositae, the polygala tenuifolia Willd. Of Polygala tenuifolia of Polygalaceae, the liquorice is dry root of Glycyrrhiza uralensis Fisch. Of Leguminosae, the ganoderma lucidum is whole plant of Ganoderma sinensis or Ganoderma lucidum of Polyporaceae, herba Agastaches is dry aerial part of herba Agastaches Pogostemon cablin (Blanco) Benth of Labiatae, herba Menthae is dry aerial part of herba Menthae Mentha haplocalyx Briq of Mentha of Labiatae, sea salt is crystal formed by decocting and drying salt water in seawater, folium Bambusae is leaf of herba Lophatheri of Gramineae, notoginseng radix is dry root of Panax notoginseng (Burk.) F.H.Chen of Araliaceae, perillae is branch-bearing tender leaf of Perilla frutescens (L.) Britt. Of Perilla of Labiatae;
as a preferable technical proposal, the friction agent is one or a combination of more of calcium carbonate, hydrated silica, calcium hydrogen phosphate dihydrate, calcium pyrophosphate, hydrated silicic acid, superfine silicon dioxide and aluminum hydroxide;
as a more preferable technical scheme, the friction agent is a compound of calcium hydrophosphate dihydrate, silicic acid hydrate and aluminum hydroxide, and the mass ratio of the friction agent to the calcium hydrophosphate hydrate to the silicic acid hydrate to the aluminum hydroxide is 0.2-0.5:0.4-0.7:0.5-0.8;
as a preferred technical solution, the humectant is one or a combination of more of sorbitol, glycerol, propylene glycol and polyethylene glycol;
as a more preferable technical scheme, the humectant is a compound of propylene glycol and sorbitol, and the mass ratio of the humectant to the sorbitol is 0.2-0.5:0.7-0.9;
as a preferred technical solution, the surfactant is one or a combination of more of potassium lauroyl glutamate, sodium cocoyl glutamate, potassium cocoyl glutamate, sodium lauryl sulfate, sodium dodecyl benzene iodate, sodium methyl coco taurate, sodium lauryl sulfate, sodium lauroyl sarcosinate, polyoxyethylene hydrogenated castor oil, and vitamin E polyethylene glycol succinate;
as a more preferable technical scheme, the surfactant is a compound of polyethylene glycol 400 and D-alpha-vitamin E polyethylene glycol succinate, and the mass ratio of the surfactant to the polyethylene glycol succinate is 0.6-0.9:0.3-0.5;
as a preferred technical scheme, the thickening agent is one or more of sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer resin, xanthan gum, sodium caseinate, hydroxypropyl guar gum, silicon dioxide and poloxamer;
as a more preferable technical scheme, the thickening agent is a compound of hydroxyethyl cellulose, sodium caseinate and hydroxypropyl guar gum, and the mass ratio of the thickening agent to the thickening agent is 0.5-0.8:0.6-0.9:1.2-1.4;
as a preferred technical scheme, the preservative is one or a combination of more of potassium sorbate, sodium benzoate, sorbic acid and sodium propionate;
as a more selected technical scheme, the preservative is a compound of potassium sorbate and sodium propionate, and the mass ratio of the preservative to the preservative is 0.4-0.9:0.7-1.4;
as a preferable technical scheme, the PH regulator is one or a combination of more of potassium citrate, lactic acid, tartaric acid, malic acid, sodium citrate and tripolyphosphoric acid;
as a preferable technical scheme, the pH regulator is a compound of sodium citrate and potassium citrate, and the mass ratio of the pH regulator to the potassium citrate is 0.5-0.8:0.4-1.1.
The second aspect of the invention provides a preparation method of a Chinese herbal medicine toothpaste for refreshing breath, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing the traditional Chinese medicine extract in a decocting pot, adding 6-8 times of water for decocting at 70-80 ℃ for 2-3 h, filtering to obtain a primary filtrate, repeating the water-adding decocting process twice, filtering to obtain a secondary filtrate and a tertiary filtrate, combining the primary filtrate, the secondary filtrate and the tertiary filtrate, placing the combined filtrate in an evaporation and concentration device, filtering and concentrating the tertiary decocting, and combining the combined filtrate to 25-30 ℃ to obtain the traditional Chinese medicine extract for later use;
(4) Mixing the Chinese medicinal extract, water and humectant, and stirring;
(5) Weighing a friction agent, a thickening agent, a preservative and a PH preservative, putting the friction agent, the thickening agent, the preservative and the PH preservative into a powder tank, and uniformly stirring for later use;
(4) Opening a vacuum system of the paste making tank, vacuumizing to-0.05 Mpa, starting a low-speed stirrer at the same time, starting to feed the materials in the step (3), starting a high-speed stirrer at the moment, keeping the vacuum degree of the paste making tank between-0.06 Mpa and-0.095 Mpa, stirring and homogenizing for 40min to 50min, adding a surfactant, keeping the vacuum degree of the paste making tank between-0.06 Mpa and-0.095 Mpa, and continuing homogenizing for 20min;
(5) Degassing the paste making tank to a vacuum degree of-0.095 Mpa to-0.100 Mpa, keeping the vacuum degree of the paste making tank for 25min to 30min, opening a normal pressure valve, deflating a vacuum system of the paste making tank, and finally discharging paste to prepare the Chinese herbal medicine toothpaste with fresh breath.
Advantageous effects
(1) The Chinese herbal medicine toothpaste capable of refreshing breath is prepared by mixing the Chinese herbal medicine extract and the humectant, and adding and mixing the abrasive, the thickening agent, the preservative, the pH regulator and the surfactant, and has excellent stability and strong cleaning power.
(2) The invention can make the prepared Chinese herbal medicine toothpaste with fresh breath help smokers to effectively remove the peculiar smell in the oral cavity by adding the Chinese herbal medicine extract, especially when the Chinese herbal medicine extract is wormwood, polygala tenuifolia, liquorice, lucid ganoderma, patchouli, mint, sea salt, bamboo leaves, pseudo-ginseng and perilla frutescens, the prepared Chinese herbal medicine toothpaste with fresh breath can effectively remove the peculiar smell in the oral cavity of smokers, the reasons can be that the wormwood is pungent, bitter and warm, can dispel cold and relieve pain, the channels are warm to stop bleeding, the polygala tenuifolia is bitter, pungent and warm, can treat sore and ulcer pyogenic infections and detumescence, the liquorice is sweet and mild in nature, can clear away heat and toxic materials, and relieve spasm and pain, the lucid ganoderma is sweet and warm in nature, can relieve asthma, insomnia and dyspepsia, the patchouli is spicy and warm in nature, can disperse damp turbidity, awaken spleen and stomach, the peppermint is spicy and cool in nature, can disperse wind heat, clear head and eyes, the sea salt is salty, salty and cold in nature, can cause vomiting, clear fire, cool blood, remove toxin, the bamboo leaves are sweet and light in nature, cold in nature, can clear heat and relieve restlessness, promote salivation and induce diuresis, the pseudo-ginseng is sweet, slightly bitter and warm in nature, can dissipate blood stasis and stop bleeding, relieve swelling and pain, the perilla is spicy and warm in nature, can dispel cold and relieve exterior syndrome, and regulate qi to be wide and moderate, and the prepared traditional Chinese medicine extracts are compatible for use and have synergistic effect to help smokers to effectively refresh mouth smell and relieve oral peculiar smell.
(3) The invention can ensure that the prepared Chinese herbal medicine toothpaste for refreshing breath has abundant bubbles, strong quick cleaning power and can improve the stability of the toothpaste by adding the surfactant, and particularly, the surfactant is the compound of polyethylene glycol 400 and vitamin E polyethylene glycol succinate, and the mass ratio of the surfactant to the surfactant is 0.6-0.9:0.3-0.4, the obtained Chinese herbal toothpaste with fresh breath has rapid foaming, abundant foam, and excellent stability, probably because the molecular formula of polyethylene glycol 400 is HO (CH) 2 CH 2 O) 400 H is a zigzag long-chain structure, the long chain is changed into a zigzag structure after being dissolved in water, the oxygen bridging atom of the hydrophilic polar group in the molecular structure is pulled out by water molecules and is positioned at the outer side of the long-chain molecular structure, and nonpolar-CH 2 -CH 2 The cross-linked network structure is formed by curling zigzag long-chain molecules into different shapes to form a cross-linked network structure, a hydrophilic shell consisting of oxygen-bridging atoms is formed outside each polyethylene glycol 400 long-chain molecule to form micelles with hydrophilic polar groups facing outwards and non-polar groups facing inwards, the D-alpha-tocopheryl polyethylene glycol succinate contains tocopheryl and polyethylene glycol hydrophilic long chains, has excellent water solubility and can form nano-micelles, the nano-micelles are tightly distributed on the surface of the solution in a synergistic manner to increase the strength of the foam surface membrane and inhibit liquid flowing away below the surface layer of the foam surface membrane to prevent the foam surface membrane from thinning, the strength is high, the surfactant molecules are tightly distributed to effectively slow gas in the foam surface membrane to permeate through the foam surface membrane, the foam stability is improved, the flow speed and evaporation speed of a water layer between foam walls are effectively reduced, the rupture of the foam walls is prevented, the polyethylene glycol hydrophilic long chains in the vitamin E polyethylene glycol succinate can diffuse into the cross-linked network structure molecular structure of the polyethylene glycol 400 to form uniformly dispersed and tightly distributed micelles, the sea salt extract in the traditional Chinese medicine extract can be adsorbed in the hydrophilic shell, the oxygen-bridging atoms in the traditional Chinese medicine extract are dissolved in the solvent, and the solvent of the sea salt extract is inhibited, and the traditional Chinese medicine extract, and the solubility is effectively dissolved in the solvent, and the traditional medicine extractThe separation, thickening and agglomeration of the sea salt extract in the toothpaste can be avoided, and hydrophobic organic molecules and organic molecules in the thickening agent can enter micelles with the same polarity as the hydrophobic organic molecules, so that the compatibility of a Chinese herbal medicine toothpaste solution system is further improved, and the stability of the Chinese herbal medicine toothpaste is improved.
(4) The invention can lead the prepared Chinese herbal medicine toothpaste with fresh breath to have better stability by adding the thickening agent, in particular to the thickening agent which is the compound of hydroxyethyl cellulose, sodium caseinate and hydroxypropyl guar gum, and the mass ratio of the thickening agent is 0.5-0.8:0.6-0.9:1.2-1.4, the prepared Chinese herbal medicine toothpaste for freshening breath is excellent in stability, probably because a hydrophobic main chain in hydroxyethyl cellulose is associated with water molecules around a solution through hydrogen bonds, the fluid volume of a polymer is increased, free moving spaces of molecules such as a Chinese herbal medicine extract surfactant in the solution are reduced, the viscosity of the solution system is increased, sodium caseinate contains long-chain molecules, hydroxypropyl guar gum contains polymer molecular chains, the long chains of the molecules are intertwined after the three are compounded and are uniformly and tightly dispersed in the solution system, the free moving spaces of the molecules are further reduced, molecules of the Chinese herbal medicine extract, the surfactant, a friction agent, a thickening agent, a preservative, a pH regulator and a humectant are uniformly dispersed in molecules of the thickening agent, the prepared Chinese herbal medicine toothpaste for freshening breath has excellent stability, the compatibility of the Chinese herbal medicine toothpaste with the surfactant is good, the Chinese herbal medicine toothpaste can be uniformly dispersed in micelles formed by the surfactant, and the synergistic effect of the two further increases the compatibility of the prepared Chinese herbal medicine toothpaste solution, and the toothpaste is excellent in stability.
(5) The Chinese herbal medicine toothpaste capable of refreshing breath is prepared by mixing the traditional Chinese medicine extract, water and the humectant, placing the mixture into an ointment preparation tank, stirring and mixing, adding the abrasive, the thickening agent, the preservative and the pH regulator, mixing, and finally adding the surfactant for homogenization.
Detailed Description
Example 1
The embodiment 1 provides a Chinese herbal medicine toothpaste for refreshing breath, which comprises the following preparation raw materials in parts by weight: 34 parts of traditional Chinese medicine extract, 2 parts of abrasive, 5 parts of humectant, 3 parts of surfactant, 0.5 part of thickening agent, 0.5 part of preservative and 0.3 part of pH regulator.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 2 parts of wormwood, 5 parts of polygala tenuifolia, 5 parts of liquorice, 2 parts of lucid ganoderma, 2 parts of pogostemon cablin, 2 parts of mint, 3 parts of sea salt, 3 parts of bamboo leaves, 5 parts of pseudo-ginseng and 5 parts of purple perilla;
the friction agent is a compound of calcium hydrophosphate dihydrate, hydrated silicic acid and aluminum hydroxide, and the mass ratio of the friction agent to the mixed material is 0.2:0.4:0.5, CAS number 7789-77-7 for calcium hydrogen phosphate dihydrate, available from Schoenberg chemical (Shanghai) Co., ltd., CAS number 7699-41-4 for silicic acid hydrate, available from chemical Co., ltd., waverrucke, beijing;
the humectant is a compound of propylene glycol and sorbitol, and the mass ratio of the humectant to the sorbitol is 0.2:0.7, propylene glycol CAS number 57-55-6, available from Shanghai Aladdin Biotechnology Ltd, sorbitol CAS number 25322-68-3, available from Shanghai Aladdin Biotechnology Ltd;
the surfactant is a compound of polyethylene glycol 400 and D-alpha-vitamin E polyethylene glycol succinate, and the mass ratio of the surfactant to the surfactant is 0.6:0.3 polyethylene glycol 400, CAS No. 25322-68-3, available from sigma aldrich (shanghai) trade company, D- α -tocopheryl polyethylene glycol succinate CAS No. 9002-96-4, available from sigma aldrich (shanghai) trade company;
the thickening agent is a compound of hydroxyethyl cellulose, sodium caseinate and hydroxypropyl guar gum, and the mass ratio of the thickening agent to the thickening agent is 0.5:0.6:1.2 hydroxyethyl cellulose CAS No. 9004-62-0, available from sigma aldrich trade ltd, sodium caseinate CAS No. 9005-46-3, available from michelin biochemical technologies ltd, hydroxypropyl guar CAS No. 9000-30-0, available from shanghai-sourced leaf biotechnology ltd;
the preservative is a compound of potassium sorbate and sodium propionate, and the mass ratio of the preservative to the preservative is 0.4:0.7, potassium sorbate CAS No. 24634-61-5, available from Mecanum Biochemical Co., ltd, sodium propionate CAS No. 137-40-6, available from Mecanum Biochemical Co., ltd;
the pH regulator is a compound of sodium citrate and potassium citrate, and the mass ratio of the pH regulator to the sodium citrate is 0.5:0.4, sodium citrate CAS number 68-04-2, available from Shanghai Michelin Biotech, inc., and potassium citrate CAS number 866-84-2, available from Shandong Fengtai, biotech, inc.
The second aspect of the invention provides a preparation method of a Chinese herbal medicine toothpaste for freshening breath, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing the traditional Chinese medicine extract in a decocting pot, adding 6 times of water for decocting at 70 ℃ for 2 hours, filtering to obtain a primary filtrate, repeating the water-adding decocting process twice, filtering to obtain a secondary filtrate and a tertiary filtrate, combining the primary filtrate, the secondary filtrate and the tertiary filtrate, placing the combined filtrate in an evaporation and concentration device, filtering and concentrating the tertiary decoction, and combining the combined filtrate to 25 ℃ to obtain the traditional Chinese medicine extract for later use;
(2) Mixing the Chinese medicinal extract, water and humectant, and stirring;
(3) Weighing a friction agent, a thickening agent, a preservative and a PH preservative, putting the friction agent, the thickening agent, the preservative and the PH preservative into a powder tank, and uniformly stirring for later use;
(4) Opening a vacuum system of the paste making tank, vacuumizing to-0.05 Mpa, starting a low-speed stirrer at the same time, starting to feed the materials in the step (3), starting a high-speed stirrer at the moment, keeping the vacuum degree of the paste making tank at-0.06 Mpa, stirring and homogenizing for 40-50 min, adding a surfactant, keeping the vacuum degree of the paste making tank at-0.06 Mpa, and continuing homogenizing for 20min;
(5) Degassing the paste making tank to vacuum degree of-0.095 Mpa, maintaining the vacuum value for 25min, opening a normal pressure valve, discharging gas from the vacuum system of the paste making tank, and discharging paste to obtain the Chinese herbal medicine toothpaste with fresh breath.
Example 2
Embodiment 2 provides a Chinese herbal medicine toothpaste for freshening breath, which comprises the following raw materials in parts by weight: 75 parts of traditional Chinese medicine extract, 7 parts of an abrasive, 10 parts of a humectant, 10 parts of a surfactant, 1 part of a thickener, 1 part of a preservative and 1 part of a pH regulator.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 5 parts of wormwood, 10 parts of polygala tenuifolia, 10 parts of liquorice, 5 parts of lucid ganoderma, 5 parts of pogostemon cablin, 10 parts of mint, 5 parts of sea salt, 5 parts of bamboo leaves, 10 parts of pseudo-ginseng and 10 parts of purple perilla;
the friction agent is a compound of calcium hydrophosphate dihydrate, silicic acid hydrate and aluminum hydroxide, and the mass ratio of the friction agent to the calcium hydrophosphate dihydrate is 0.5:0.7:0.8, CAS number 7789-77-7 for calcium hydrogen phosphate dihydrate, available from Schoenberg chemical (Shanghai) Co., ltd., CAS number 7699-41-4 for silicic acid hydrate, available from chemical Co., ltd., waverrucke, beijing;
the humectant is a compound of propylene glycol and sorbitol, and the mass ratio of the humectant to the sorbitol is 0.5:0.9, propylene glycol CAS No. 57-55-6, available from Shanghai Allantin Biotechnology Co., ltd, sorbitol CAS No. 25322-68-3, available from Shanghai Allantin Biotechnology Co., ltd;
the surfactant is a compound of polyethylene glycol 400 and D-alpha-vitamin E polyethylene glycol succinate, and the mass ratio of the surfactant to the surfactant is 0.9:0.5 polyethylene glycol 400, CAS number 25322-68-3, available from Sigma Aldrich (Shanghai) trade company Limited, D-alpha-tocopheryl polyethylene glycol succinate CAS number 9002-96-4, available from Sigma Aldrich (Shanghai) trade company Limited;
the thickening agent is a compound of hydroxyethyl cellulose, sodium caseinate and hydroxypropyl guar gum, and the mass ratio of the thickening agent to the thickening agent is 0.8:0.9:1.4 hydroxyethyl cellulose CAS No. 9004-62-0, available from sigma aldrich trade ltd, sodium caseinate CAS No. 9005-46-3, available from michelin biochemical technologies ltd, hydroxypropyl guar CAS No. 9000-30-0, available from shanghai-sourced leaf biotechnology ltd;
the preservative is a compound of potassium sorbate and sodium propionate, and the mass ratio of the preservative to the preservative is 0.9:1.4, CAS No. 24634-61-5 for potassium sorbate, from Shanghai Michelin Biochemical technology, inc., CAS No. 137-40-6 for sodium propionate, from Shanghai Michelin Biochemical technology, inc.;
the pH regulator is a compound of sodium citrate and potassium citrate, and the mass ratio of the pH regulator to the sodium citrate is 0.8:1.1, sodium citrate CAS number 68-04-2, available from Shanghai Michelin Biotechnology Ltd, potassium citrate CAS number 866-84-2, available from Shandong Fengtai Biotechnology Ltd.
The second aspect of the invention provides a preparation method of a Chinese herbal medicine toothpaste for freshening breath, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing the traditional Chinese medicine extract in a decocting pot, adding water with volume of 8 times, decocting at 80 deg.C for 3h, filtering to obtain a primary filtrate, repeating the above decocting process with water twice, filtering to obtain a secondary filtrate and a tertiary filtrate, mixing the primary filtrate, the secondary filtrate and the tertiary filtrate, placing in an evaporation concentration device, filtering, concentrating, and mixing the filtrates to 30 deg.C to obtain a traditional Chinese medicine extract for use;
(2) Mixing the Chinese medicinal extract, water and humectant, and stirring;
(3) Weighing a friction agent, a thickening agent, a preservative and a PH preservative, putting the friction agent, the thickening agent, the preservative and the PH preservative into a powder tank, and uniformly stirring for later use;
(4) Opening a vacuum system of the paste making tank, vacuumizing to-0.05 Mpa, starting a low-speed stirrer at the same time, starting to feed the materials in the step (3), starting a high-speed stirrer at the moment, keeping the vacuum degree of the paste making tank at-0.095 Mpa, stirring and homogenizing for 50min, adding a surfactant, keeping the vacuum degree of the paste making tank at-0.095 Mpa, and continuing to homogenize for 20min;
(5) Degassing the paste preparation tank to a vacuum degree of-0.100 Mpa, maintaining the vacuum value for 30min, opening a normal pressure valve, discharging gas from the vacuum system of the paste preparation tank, and finally discharging paste to obtain the Chinese herbal medicine toothpaste with fresh breath.
Example 3
Embodiment 3 provides a Chinese herbal medicine toothpaste for freshening breath, which comprises the following preparation raw materials in parts by weight: 53 parts of traditional Chinese medicine extract, 5 parts of abrasive, 8 parts of humectant, 8 parts of surfactant, 0.7 part of thickening agent, 0.7 part of preservative and 0.6 part of pH regulator.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 4 parts of wormwood, 7 parts of polygala tenuifolia, 7 parts of liquorice, 3 parts of lucid ganoderma, 3 parts of pogostemon cablin, 7 parts of mint, 4 parts of sea salt, 4 parts of bamboo leaves, 6 parts of pseudo-ginseng and 8 parts of purple perilla;
the friction agent is a compound of calcium hydrophosphate dihydrate, hydrated silicic acid and aluminum hydroxide, and the mass ratio of the friction agent to the mixed material is 0.3:0.6:0.7, CAS number 7789-77-7 for calcium hydrogen phosphate dihydrate, available from Schoenberg chemical (Shanghai) Co., ltd., CAS number 7699-41-4 for silicic acid hydrate, available from chemical Co., ltd., waverrucke, beijing;
the humectant is a compound of propylene glycol and sorbitol, and the mass ratio of the humectant to the sorbitol is 0.3:0.8, propylene glycol CAS number 57-55-6, ex Shanghai Aladdin Biotechnology, inc., sorbitol CAS number 25322-68-3, ex Shanghai Aladdin Biotechnology, inc.;
the surfactant is a compound of polyethylene glycol 400 and D-alpha-vitamin E polyethylene glycol succinate, and the mass ratio of the surfactant to the surfactant is 0.7:0.4 polyethylene glycol 400, CAS No. 25322-68-3, available from sigma aldrich (shanghai) trade company, D- α -tocopheryl polyethylene glycol succinate CAS No. 9002-96-4, available from sigma aldrich (shanghai) trade company;
the thickening agent is a compound of hydroxyethyl cellulose, sodium caseinate and hydroxypropyl guar gum, and the mass ratio of the thickening agent to the thickening agent is 0.7:0.8:1.3, hydroxyethylcellulose CAS number 9004-62-0, from sigma aldrich trade ltd, sodium caseinate CAS number 9005-46-3, from shanghai mcolin biochem ltd, hydroxypropyl guar CAS number 9000-30-0, from shanghai leaf biotechnology ltd;
the preservative is a compound of potassium sorbate and sodium propionate, and the mass ratio of the preservative to the preservative is 0.7:1.1, potassium sorbate CAS No. 24634-61-5, available from Mecanum Biochemical Co., ltd, sodium propionate CAS No. 137-40-6, available from Mecanum Biochemical Co., ltd;
the pH regulator is a compound of sodium citrate and potassium citrate, and the mass ratio of the pH regulator to the sodium citrate is 0.7:0.8, sodium citrate CAS number 68-04-2, available from Shanghai Michelin Biotech, inc., and potassium citrate CAS number 866-84-2, available from Shandong Fengtai, biotech, inc.
The second aspect of the invention provides a preparation method of a Chinese herbal medicine toothpaste for freshening breath, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing the traditional Chinese medicine extract in a decocting pot, adding water with volume of 7 times, decocting at 75 deg.C for 2.5h, filtering to obtain primary filtrate, repeating the above decocting process with water twice, filtering to obtain secondary filtrate and tertiary filtrate, mixing the primary filtrate, the secondary filtrate and the tertiary filtrate, placing in an evaporation concentration device, filtering, concentrating, and mixing the filtrates to 27 deg.C to obtain traditional Chinese medicine extract;
(2) Mixing the Chinese medicinal extract, water and humectant, and stirring;
(3) Weighing a friction agent, a thickening agent, a preservative and a PH preservative, putting the friction agent, the thickening agent, the preservative and the PH preservative into a powder tank, and uniformly stirring for later use;
(4) Opening a vacuum system of the paste making tank, vacuumizing to-0.05 Mpa, starting a low-speed stirrer at the same time, starting to feed the materials in the step (3), starting a high-speed stirrer at the moment, keeping the vacuum degree of the paste making tank at-0.075 Mpa, stirring and homogenizing for 45min, adding a surfactant, keeping the vacuum degree of the paste making tank at-0.075 Mpa, and continuing homogenizing for 20min;
(5) Degassing the paste preparation tank to a vacuum degree of-0.098 Mpa, maintaining the vacuum degree for 27min, opening a normal pressure valve, discharging gas from the vacuum system of the paste preparation tank, and discharging paste to obtain the Chinese herbal medicine toothpaste with fresh breath.
Comparative example 1
Comparative example 1 provides a Chinese herbal medicine toothpaste for refreshing breath, which comprises the following preparation raw materials in parts by weight: 53 parts of traditional Chinese medicine extract, 5 parts of abrasive, 8 parts of humectant, 8 parts of surfactant, 0.7 part of thickening agent, 0.7 part of preservative and 0.6 part of pH regulator.
The traditional Chinese medicine extract comprises the following preparation raw materials in parts by weight: 4 parts of wormwood, 7 parts of polygala tenuifolia, 7 parts of liquorice, 3 parts of lucid ganoderma, 3 parts of pogostemon cablin, 7 parts of mint, 4 parts of sea salt, 4 parts of bamboo leaves, 6 parts of pseudo-ginseng and 8 parts of purple perilla;
the friction agent is a compound of calcium hydrophosphate dihydrate, hydrated silicic acid and aluminum hydroxide, and the mass ratio of the friction agent to the mixed material is 0.3:0.6:0.7, CAS number 7789-77-7 for calcium hydrogen phosphate dihydrate, available from Schoenberg chemical (Shanghai) Co., ltd., CAS number 7699-41-4 for silicic acid hydrate, available from chemical Co., ltd., waverrucke, beijing;
the humectant is a compound of propylene glycol and sorbitol, and the mass ratio of the humectant to the sorbitol is 0.3:0.8, propylene glycol CAS number 57-55-6, ex Shanghai Aladdin Biotechnology, inc., sorbitol CAS number 25322-68-3, ex Shanghai Aladdin Biotechnology, inc.;
the surfactant is a compound of polyethylene glycol 400 and D-alpha-vitamin E polyethylene glycol succinate, and the mass ratio of the surfactant to the surfactant is 0.3:0.4 polyethylene glycol 400 having a CAS number of 25322-68-3, available from sigma aldrich (shanghai) trade company, D- α -vitamin E polyethylene glycol succinate CAS number 9002-96-4, available from sigma aldrich (shanghai) trade company;
the thickening agent is a compound of hydroxyethyl cellulose, sodium caseinate and hydroxypropyl guar gum, and the mass ratio of the thickening agent to the thickening agent is 0.7:0.8:1.3 hydroxyethyl cellulose CAS No. 9004-62-0, available from sigma aldrich trade ltd, sodium caseinate CAS No. 9005-46-3, available from michelin biochemical technologies ltd, hydroxypropyl guar CAS No. 9000-30-0, available from shanghai-sourced leaf biotechnology ltd;
the preservative is a compound of potassium sorbate and sodium propionate, and the mass ratio of the preservative to the preservative is 0.7:1.1, CAS No. 24634-61-5 for potassium sorbate, from Shanghai Michelin Biochemical technology, inc., CAS No. 137-40-6 for sodium propionate, from Shanghai Michelin Biochemical technology, inc.;
the PH regulator is a compound of sodium citrate and potassium citrate, and the mass ratio of the pH regulator to the potassium citrate is 0.7:0.8, sodium citrate CAS number 68-04-2, available from Shanghai Maxin Biotechnology, inc., and potassium citrate CAS number 866-84-2, available from Shandong Fengtai Biotechnology, inc.
The second aspect of the invention provides a preparation method of a Chinese herbal medicine toothpaste for refreshing breath, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing the traditional Chinese medicine extract in a decocting pot, adding water with volume of 7 times, decocting at 75 deg.C for 2.5h, filtering to obtain primary filtrate, repeating the above decocting process with water twice, filtering to obtain secondary filtrate and tertiary filtrate, mixing the primary filtrate, the secondary filtrate and the tertiary filtrate, placing in an evaporation concentration device, filtering, concentrating, and mixing the filtrates to 27 deg.C to obtain traditional Chinese medicine extract;
(2) Mixing the Chinese medicinal extract, water and humectant, and stirring;
(3) Weighing a friction agent, a thickening agent, a preservative and a PH preservative, putting the friction agent, the thickening agent, the preservative and the PH preservative into a powder tank, and uniformly stirring for later use;
(4) Opening a vacuum system of the paste making tank, vacuumizing to-0.05 Mpa, starting a low-speed stirrer at the same time, starting to feed the materials in the step (3), starting a high-speed stirrer at the moment, keeping the vacuum degree of the paste making tank at-0.075 Mpa, stirring and homogenizing for 45min, adding a surfactant, keeping the vacuum degree of the paste making tank at-0.075 Mpa, and continuing homogenizing for 20min;
(5) Degassing the paste preparation tank to a vacuum degree of-0.098 Mpa, maintaining the vacuum degree for 27min, opening a normal pressure valve, discharging gas from the vacuum system of the paste preparation tank, and discharging paste to obtain the Chinese herbal medicine toothpaste with fresh breath.
Comparative example 2
Comparative example 2 provides a Chinese herbal medicine toothpaste for freshening breath, which is prepared from the following raw materials in parts by weight: 53 parts of traditional Chinese medicine extract, 5 parts of abrasive, 8 parts of humectant, 8 parts of surfactant, 0.7 part of thickening agent, 0.7 part of preservative and 0.6 part of pH regulator.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 4 parts of wormwood, 7 parts of polygala tenuifolia, 7 parts of liquorice, 3 parts of lucid ganoderma, 3 parts of patchouli, 7 parts of mint, 4 parts of sea salt, 4 parts of bamboo leaves, 6 parts of pseudo-ginseng and 8 parts of purple perilla;
the friction agent is a compound of calcium hydrophosphate dihydrate, hydrated silicic acid and aluminum hydroxide, and the mass ratio of the friction agent to the mixed material is 0.3:0.6:0.7, CAS number 7789-77-7 for calcium hydrogen phosphate dihydrate, available from Schoenberg chemical (Shanghai) Co., ltd., CAS number 7699-41-4 for silicic acid hydrate, available from chemical Co., ltd., waverrucke, beijing;
the humectant is a compound of propylene glycol and sorbitol, and the mass ratio of the humectant to the sorbitol is 0.3:0.8, propylene glycol CAS No. 57-55-6, available from Shanghai Allantin Biotechnology Co., ltd, sorbitol CAS No. 25322-68-3, available from Shanghai Allantin Biotechnology Co., ltd;
the surfactant is D-alpha-tocopheryl polyethylene glycol succinate, the CAS number of the D-alpha-tocopheryl polyethylene glycol succinate is 9002-96-4, and the surfactant is purchased from Sigma Aldrich (Shanghai) trade company;
the thickening agent is a compound of hydroxyethyl cellulose, sodium caseinate and hydroxypropyl guar gum, and the mass ratio of the thickening agent to the thickening agent is 0.7:0.8:1.3 hydroxyethyl cellulose CAS No. 9004-62-0, available from sigma aldrich trade ltd, sodium caseinate CAS No. 9005-46-3, available from michelin biochemical technologies ltd, hydroxypropyl guar CAS No. 9000-30-0, available from shanghai-sourced leaf biotechnology ltd;
the preservative is a compound of potassium sorbate and sodium propionate, and the mass ratio of the preservative to the preservative is 0.7:1.1, CAS No. 24634-61-5 for potassium sorbate, from Shanghai Michelin Biochemical technology, inc., CAS No. 137-40-6 for sodium propionate, from Shanghai Michelin Biochemical technology, inc.;
the PH regulator is a compound of sodium citrate and potassium citrate, and the mass ratio of the pH regulator to the potassium citrate is 0.7:0.8, sodium citrate CAS number 68-04-2, available from Shanghai Michelin Biotech, inc., and potassium citrate CAS number 866-84-2, available from Shandong Fengtai, biotech, inc.
The second aspect of the invention provides a preparation method of a Chinese herbal medicine toothpaste for freshening breath, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing the traditional Chinese medicine extract in a decocting pot, adding water with volume of 7 times, decocting at 75 deg.C for 2.5h, filtering to obtain primary filtrate, repeating the above decocting process with water twice, filtering to obtain secondary filtrate and tertiary filtrate, mixing the primary filtrate, the secondary filtrate and the tertiary filtrate, placing in an evaporation concentration device, filtering, concentrating, and mixing the filtrates to 27 deg.C to obtain traditional Chinese medicine extract;
(2) Mixing the Chinese medicinal extract, water and humectant, and stirring;
(3) Weighing a friction agent, a thickening agent, a preservative and a PH preservative, putting the friction agent, the thickening agent, the preservative and the PH preservative into a powder tank, and uniformly stirring for later use;
(4) Opening a vacuum system of the paste making tank, vacuumizing to-0.05 Mpa, starting a low-speed stirrer at the same time, starting to feed the materials in the step (3), starting a high-speed stirrer at the moment, keeping the vacuum degree of the paste making tank at-0.075 Mpa, stirring and homogenizing for 45min, adding a surfactant, keeping the vacuum degree of the paste making tank at-0.075 Mpa, and continuing homogenizing for 20min;
(5) Degassing the toothpaste preparation tank to a vacuum degree of-0.098 Mpa, maintaining the vacuum degree for 27min, opening a normal pressure valve, discharging gas from the vacuum system of the toothpaste preparation tank, and discharging toothpaste to obtain the Chinese herbal medicine toothpaste with fresh breath.
Comparative example 3
Comparative example 3 provides a Chinese herbal medicine toothpaste for freshening breath, which comprises the following preparation raw materials in parts by weight: 53 parts of traditional Chinese medicine extract, 5 parts of abrasive, 8 parts of humectant, 8 parts of surfactant, 0.7 part of thickening agent, 0.7 part of preservative and 0.6 part of pH regulator.
The traditional Chinese medicine extract comprises the following preparation raw materials in parts by weight: 4 parts of wormwood, 7 parts of polygala tenuifolia, 7 parts of liquorice, 3 parts of lucid ganoderma, 3 parts of pogostemon cablin, 7 parts of mint, 4 parts of sea salt, 4 parts of bamboo leaves, 6 parts of pseudo-ginseng and 8 parts of purple perilla;
the friction agent is a compound of calcium hydrophosphate dihydrate, silicic acid hydrate and aluminum hydroxide, and the mass ratio of the friction agent to the calcium hydrophosphate dihydrate is 0.3:0.6:0.7, CAS number 7789-77-7 for calcium hydrogen phosphate dihydrate, available from Schoenberg chemical (Shanghai) Co., ltd., CAS number 7699-41-4 for silicic acid hydrate, available from chemical Co., ltd., waverrucke, beijing;
the humectant is a compound of propylene glycol and sorbitol, and the mass ratio of the humectant to the sorbitol is 0.3:0.8, propylene glycol CAS number 57-55-6, ex Shanghai Aladdin Biotechnology, inc., sorbitol CAS number 25322-68-3, ex Shanghai Aladdin Biotechnology, inc.;
the surfactant is a compound of polyethylene glycol 400 and D-alpha-vitamin E polyethylene glycol succinate, and the mass ratio of the surfactant to the surfactant is 0.2:0.3 polyethylene glycol 400 having a CAS number of 25322-68-3, available from sigma aldrich (shanghai) trade company, D- α -tocopheryl polyethylene glycol succinate CAS number 9002-96-4, available from sigma aldrich (shanghai) trade company;
the thickening agent is a compound of hydroxyethyl cellulose, sodium caseinate and hydroxypropyl guar gum, and the mass ratio of the thickening agent to the thickening agent is 0.5:0.2:0.6, hydroxyethylcellulose CAS number 9004-62-0, available from Sigma Aldrich trade, inc., sodium caseinate CAS number 9005-46-3, available from Shanghai Maxin Biotechnology, inc., hydroxypropyl guar CAS number 9000-30-0, available from Shanghai Yuanye Biotechnology, inc.;
the preservative is a compound of potassium sorbate and sodium propionate, and the mass ratio of the preservative to the preservative is 0.7:1.1, CAS No. 24634-61-5 for potassium sorbate, from Shanghai Michelin Biochemical technology, inc., CAS No. 137-40-6 for sodium propionate, from Shanghai Michelin Biochemical technology, inc.;
the pH regulator is a compound of sodium citrate and potassium citrate, and the mass ratio of the pH regulator to the sodium citrate is 0.7:0.8, sodium citrate CAS number 68-04-2, available from Shanghai Michelin Biotech, inc., and potassium citrate CAS number 866-84-2, available from Shandong Fengtai, biotech, inc.
The second aspect of the invention provides a preparation method of a Chinese herbal medicine toothpaste for refreshing breath, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing the traditional Chinese medicine extract in a decocting pot, adding water with the volume of 7 times, decocting at 75 ℃ for 2.5 hours, filtering to obtain a primary filtrate, repeating the water-adding decocting process twice, filtering to obtain a secondary filtrate and a tertiary filtrate, combining the primary filtrate, the secondary filtrate and the tertiary filtrate, placing the combined primary filtrate, the secondary filtrate and the tertiary filtrate in an evaporation and concentration device, filtering and concentrating the tertiary decoction, and combining the combined filtrate to 27 ℃ to obtain a traditional Chinese medicine extract for later use;
(2) Mixing the Chinese medicinal extract, water and humectant, and stirring;
(3) Weighing a friction agent, a thickening agent, a preservative and a PH preservative, putting the friction agent, the thickening agent, the preservative and the PH preservative into a powder tank, and uniformly stirring for later use;
(4) Opening the vacuum system of the paste making tank, vacuumizing to-0.05 Mpa, and starting low-speed stirring
Stirring the materials in the step (3) by a stirrer, keeping the vacuum degree of the paste making tank at-0.075 Mpa, stirring and homogenizing for 45min, adding surfactant, keeping the vacuum degree of the paste making tank at-0.075 Mpa, and continuously homogenizing for 20min;
(5) Degassing the paste preparation tank to a vacuum degree of-0.098 Mpa, maintaining the vacuum degree for 27min, opening a normal pressure valve, discharging gas from the vacuum system of the paste preparation tank, and discharging paste to obtain the Chinese herbal medicine toothpaste with fresh breath.
Comparative example 4
Comparative example 4 provides a Chinese herbal medicine toothpaste for freshening breath, which is prepared from the following raw materials in parts by weight: 53 parts of traditional Chinese medicine extract, 5 parts of an abrasive, 8 parts of a humectant, 8 parts of a surfactant, 0.7 part of a thickening agent, 0.7 part of a preservative and 0.6 part of a pH regulator.
The traditional Chinese medicine extract comprises the following preparation raw materials in parts by weight: 4 parts of wormwood, 7 parts of polygala tenuifolia, 7 parts of liquorice, 3 parts of lucid ganoderma, 3 parts of pogostemon cablin, 7 parts of mint, 4 parts of sea salt, 4 parts of bamboo leaves, 6 parts of pseudo-ginseng and 8 parts of purple perilla;
the friction agent is a compound of calcium hydrophosphate dihydrate, hydrated silicic acid and aluminum hydroxide, and the mass ratio of the friction agent to the mixed material is 0.3:0.6:0.7, CAS number 7789-77-7 for calcium hydrogen phosphate dihydrate, available from Schoenberg chemical (Shanghai) Co., ltd., CAS number 7699-41-4 for silicic acid hydrate, available from chemical Co., ltd., waverrucke, beijing;
the humectant is a compound of propylene glycol and sorbitol, and the mass ratio of the humectant to the sorbitol is 0.3:0.8, propylene glycol CAS No. 57-55-6, available from Shanghai Allantin Biotechnology Co., ltd, sorbitol CAS No. 25322-68-3, available from Shanghai Allantin Biotechnology Co., ltd;
the surfactant is a compound of polyethylene glycol 400 and D-alpha-vitamin E polyethylene glycol succinate, and the mass ratio of the surfactant to the surfactant is 0.2:0.3 polyethylene glycol 400 having a CAS number of 25322-68-3, available from sigma aldrich (shanghai) trade company, D- α -vitamin E polyethylene glycol succinate CAS number 9002-96-4, available from sigma aldrich (shanghai) trade company;
the thickening agent is a compound of hydroxyethyl cellulose, sodium caseinate and hydroxypropyl guar gum, and the mass ratio of the thickening agent to the thickening agent is 0.7:0.2:0.7, hydroxyethylcellulose CAS number 9004-62-0, available from sigma aldrich trade ltd, sodium caseinate CAS number 9005-46-3, available from michelin biochemical technologies ltd, hydroxypropyl guar CAS number 9000-30-0, available from shanghai-sourced leaf biotechnology ltd;
the preservative is a compound of potassium sorbate and sodium propionate, and the mass ratio of the preservative to the preservative is 0.7:1.1, potassium sorbate CAS No. 24634-61-5, available from Mecanum Biochemical Co., ltd, sodium propionate CAS No. 137-40-6, available from Mecanum Biochemical Co., ltd;
the pH regulator is a compound of sodium citrate and potassium citrate, and the mass ratio of the pH regulator to the sodium citrate is 0.7:0.8, sodium citrate CAS number 68-04-2, available from Shanghai Michelin Biotech, inc., and potassium citrate CAS number 866-84-2, available from Shandong Fengtai, biotech, inc.
The second aspect of the invention provides a preparation method of a Chinese herbal medicine toothpaste for freshening breath, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing the traditional Chinese medicine extract in a decocting pot, adding water with volume of 7 times, decocting at 75 deg.C for 2.5h, filtering to obtain primary filtrate, repeating the above decocting process with water twice, filtering to obtain secondary filtrate and tertiary filtrate, mixing the primary filtrate, the secondary filtrate and the tertiary filtrate, placing in an evaporation concentration device, filtering, concentrating, and mixing the filtrates to 27 deg.C to obtain traditional Chinese medicine extract;
(2) Mixing the Chinese medicinal extract, water and humectant, and stirring;
(3) Weighing a friction agent, a thickening agent, a preservative and a PH preservative, putting the friction agent, the thickening agent, the preservative and the PH preservative into a powder tank, and uniformly stirring for later use;
(4) Opening a vacuum system of the paste making tank, vacuumizing to-0.05 Mpa, starting a low-speed stirrer at the same time, starting to feed the materials in the step (3), starting a high-speed stirrer at the moment, keeping the vacuum degree of the paste making tank at-0.075 Mpa, stirring and homogenizing for 45min, adding a surfactant, keeping the vacuum degree of the paste making tank at-0.075 Mpa, and continuing homogenizing for 20min;
(5) Degassing the paste preparation tank to a vacuum degree of-0.098 Mpa, maintaining the vacuum degree for 27min, opening a normal pressure valve, discharging gas from the vacuum system of the paste preparation tank, and discharging paste to obtain the Chinese herbal medicine toothpaste with fresh breath.
Comparative example 5
Comparative example 5 provides a Chinese herbal medicine toothpaste for refreshing breath, which comprises the following preparation raw materials in parts by weight: 53 parts of traditional Chinese medicine extract, 5 parts of abrasive, 8 parts of humectant, 8 parts of surfactant, 0.7 part of thickening agent, 0.7 part of preservative and 0.6 part of pH regulator.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 4 parts of wormwood, 7 parts of polygala tenuifolia, 7 parts of liquorice, 3 parts of lucid ganoderma, 3 parts of patchouli, 7 parts of mint, 4 parts of sea salt, 4 parts of bamboo leaves, 6 parts of pseudo-ginseng and 8 parts of purple perilla;
the friction agent is a compound of calcium hydrophosphate dihydrate, hydrated silicic acid and aluminum hydroxide, and the mass ratio of the friction agent to the mixed material is 0.3:0.6:0.7, CAS number 7789-77-7 for calcium hydrophosphate dihydrate, available from Schopper Chemicals (Shanghai) Co., ltd, CAS number 7699-41-4 for silicic acid hydrate, available from chemical industries, inc. of Waverrucke, beijing Hua;
the humectant is a compound of propylene glycol and sorbitol, and the mass ratio of the humectant to the sorbitol is 0.3:0.8, propylene glycol CAS
57-55-6 from Shanghai Aladdin Biotech, inc., and 25322-68-3 from Cassia sorbitol, inc.;
the surfactant is a compound of polyethylene glycol 400 and D-alpha-vitamin E polyethylene glycol succinate, and the mass ratio of the surfactant to the surfactant is 0.2:0.3 polyethylene glycol 400 having a CAS number of 25322-68-3, available from sigma aldrich (shanghai) trade company, D- α -vitamin E polyethylene glycol succinate CAS number 9002-96-4, available from sigma aldrich (shanghai) trade company;
the thickening agent is sodium caseinate, the CAS number of the sodium caseinate is 9005-46-3, and the thickening agent is purchased from Shanghai Maxin Biotechnology Co., ltd;
the preservative is a compound of potassium sorbate and sodium propionate, and the mass ratio of the preservative to the preservative is 0.7:1.1, CAS No. 24634-61-5 for potassium sorbate, from Shanghai Michelin Biochemical technology, inc., CAS No. 137-40-6 for sodium propionate, from Shanghai Michelin Biochemical technology, inc.;
the PH regulator is a compound of sodium citrate and potassium citrate, and the mass ratio of the pH regulator to the potassium citrate is 0.7:0.8, sodium citrate CAS number 68-04-2, available from Shanghai Michelin Biotech, inc., and potassium citrate CAS number 866-84-2, available from Shandong Fengtai, biotech, inc.
The second aspect of the invention provides a preparation method of a Chinese herbal medicine toothpaste for refreshing breath, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing the traditional Chinese medicine extract in a decocting pot, adding water with the volume of 7 times, decocting at 75 ℃ for 2.5 hours, filtering to obtain a primary filtrate, repeating the water-adding decocting process twice, filtering to obtain a secondary filtrate and a tertiary filtrate, combining the primary filtrate, the secondary filtrate and the tertiary filtrate, placing the combined primary filtrate, the secondary filtrate and the tertiary filtrate in an evaporation and concentration device, filtering and concentrating the tertiary decoction, and combining the combined filtrate to 27 ℃ to obtain a traditional Chinese medicine extract for later use;
(2) Mixing the Chinese medicinal extract, water and humectant, and stirring;
(3) Weighing a friction agent, a thickening agent, a preservative and a PH preservative, putting the friction agent, the thickening agent, the preservative and the PH preservative into a powder tank, and uniformly stirring for later use;
(4) Opening a vacuum system of the paste making tank, vacuumizing to-0.05 Mpa, starting a low-speed stirrer at the same time, starting to feed the materials in the step (3), starting a high-speed stirrer at the moment, keeping the vacuum degree of the paste making tank at-0.075 Mpa, stirring and homogenizing for 45min, adding a surfactant, keeping the vacuum degree of the paste making tank at-0.075 Mpa, and continuing homogenizing for 20min;
(5) Degassing the paste preparation tank to a vacuum degree of-0.098 Mpa, maintaining the vacuum degree for 27min, opening a normal pressure valve, discharging gas from the vacuum system of the paste preparation tank, and discharging paste to obtain the Chinese herbal medicine toothpaste with fresh breath.
And (3) performance testing:
1: storage stability
The Chinese herbal medicine toothpaste with fresh breath prepared in the examples 1-3 and the comparative examples 1-5 is stored in a toothpaste tube, and after the toothpaste is stored for 4 months at the temperature of 0 ℃, 25 ℃ and 55 ℃, the toothpaste is opened to evaluate the stability of the toothpaste, and the evaluation standard of the stability of the toothpaste is as follows: first-stage: 8-10 min, the toothpaste liquid is hardly separated, and the second stage is as follows: 5-7 points, slightly separating toothpaste liquid, and carrying out third-stage separation: 1-4 points, the toothpaste liquid is obviously separated, and the toothpaste stability scores of examples 1-3 are respectively as follows: 9.8 points, 9.9 points, 10 points, the comparative toothpaste stability scores were: 8.5 min, 8.1 min, 8.0 min, 7.5 min and 7.0 min. The result shows that the thickener is a compound of hydroxyethyl cellulose, sodium caseinate and hydroxypropyl guar gum, and the mass ratio of the thickener to the thickener is 0.5-0.8:0.6-0.9:1.2-1.4, the prepared Chinese herbal medicine toothpaste for refreshing breath has excellent stability, good compatibility with the surfactant, and can be uniformly dispersed in micelles formed by the surfactant, and the compatibility of a prepared Chinese herbal medicine toothpaste solution system is further increased by the synergistic effect of the two components, so that the stability of the toothpaste is more excellent.
2: foaming speed and degree of foaming
60 volunteers of the Chinese herbal medicine toothpaste for refreshing breath prepared in the examples 1-3 and the comparative examples 1-3 are divided into 6 groups, a daily tooth brushing test is carried out, the foaming speed and the foam richness of the toothpaste are evaluated, the evaluation standard score range is 1-10, 10 is an optimal score, and the foaming speed scores of the toothpaste in the examples 1-3 are as follows: 9.8, 10, comparative examples 1-3 toothpaste lather rate scores were: 8.8 points, 7.5 points and 8.1 points, and the toothpaste foam richness score of examples 1-3 is as follows: 9.6, 9.8, 10 points, comparative examples 1-3 toothpaste lather rate scores were: 8.5, 7.2 and 8.0, and the results show that the surfactant is the compound of polyethylene glycol 400 and vitamin E polyethylene glycol succinate, and the mass ratio of the surfactant to the vitamin E polyethylene glycol succinate is 0.6-0.9:0.3-0.4, the prepared Chinese herbal medicine toothpaste for refreshing breath can quickly bubble, and has rich foam.
Claims (10)
1. The Chinese herbal medicine toothpaste for refreshing breath is characterized by comprising the following preparation raw materials in parts by weight: 34-75 parts of traditional Chinese medicine extract, 2-7 parts of an abrasive, 5-10 parts of a humectant, 3-10 parts of a surfactant, 0.5-1 part of a thickening agent, 0.5-1 part of a preservative and 0.3-1 part of a pH regulator.
2. The breath freshening Chinese herbal medicine toothpaste as claimed in claim 1, wherein the Chinese herbal medicine extract is prepared from raw materials comprising, by weight: 2-5 parts of wormwood, 5-10 parts of polygala tenuifolia, 5-10 parts of liquorice, 2-5 parts of lucid ganoderma, 2-5 parts of patchouli, 2-10 parts of mint, 3-5 parts of sea salt, 3-5 parts of bamboo leaves, 5-10 parts of pseudo-ginseng and 5-10 parts of perilla.
3. The breath freshening herbal toothpaste as recited in claim 1 wherein said abrasive agent is a combination of one or more of calcium carbonate, hydrated silica, dibasic calcium phosphate dihydrate, calcium pyrophosphate, hydrated silicic acid, ultra fine silica, aluminum hydroxide.
4. The breath freshening herbal toothpaste according to claim 1 wherein said surfactant is one or more of potassium lauroyl glutamate, sodium cocoyl glutamate, potassium cocoyl glutamate, sodium lauryl sulfate, sodium dodecylbenzene iodate, sodium methyl coco taurate, sodium lauryl sulfate, sodium lauroyl sarcosinate, polyoxyethylene hydrogenated castor oil, vitamin E polyethylene glycol succinate in combination.
5. The breath freshening Chinese herbal medicine toothpaste as claimed in claim 2, 3 or 4, wherein the surfactant is a complex formulation of polyethylene glycol 400 and D-alpha-tocopheryl polyethylene glycol succinate in a mass ratio of 0.6-0.9:0.3-0.5.
6. The breath freshening Chinese herbal medicine toothpaste of claim 1 wherein the thickening agent is one or more of sodium carboxymethylcellulose, hydroxyethylcellulose, carbomer resin, xanthan gum, sodium caseinate, hydroxypropyl guar gum, silicon dioxide, poloxamer in combination.
7. The Chinese herbal medicine toothpaste for freshening breath as claimed in claim 6, wherein the thickener is a compound of hydroxyethyl cellulose, sodium caseinate and hydroxypropyl guar gum in a mass ratio of 0.5-0.8:0.6-0.9:1.2-1.4.
8. The breath freshening herbal toothpaste as recited in claim 1 wherein said preservative is a combination of one or more of potassium sorbate, sodium benzoate, sorbic acid, and sodium propionate.
9. The breath freshening herbal toothpaste of claim 1 wherein the PH modifier is one or more of potassium citrate, lactic acid, tartaric acid, malic acid, sodium citrate, and tripolyphosphoric acid.
10. A method for preparing a breath freshening Chinese herbal medicine toothpaste according to any one of claims 1 to 9 comprising the steps of:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing the traditional Chinese medicine extract in a decocting pot, adding 6-8 times of water for decocting at 70-80 ℃ for 2-3 h, filtering to obtain a primary filtrate, repeating the water-adding decocting process twice, filtering to obtain a secondary filtrate and a tertiary filtrate, combining the primary filtrate, the secondary filtrate and the tertiary filtrate, placing the combined filtrate in an evaporation and concentration device, filtering and concentrating the tertiary decocting, and combining the combined filtrate to 25-30 ℃ to obtain the traditional Chinese medicine extract for later use;
(2) Mixing the Chinese medicinal extract, water and humectant, and stirring;
(3) Weighing a friction agent, a thickening agent, a preservative and a PH preservative, putting the friction agent, the thickening agent, the preservative and the PH preservative into a powder tank, and uniformly stirring for later use;
(4) Opening a vacuum system of the paste making tank, pumping vacuum to-0.05 Mpa, starting a low-speed stirrer at the same time, starting the materials in the step (3), starting a high-speed stirrer at the moment, keeping the vacuum degree of the paste making tank between-0.06 Mpa and-0.095 Mpa, stirring and homogenizing for 40min to 50min, adding a surfactant, keeping the vacuum degree of the paste making tank between-0.06 Mpa and-0.095 Mpa, and continuing homogenizing for 20min;
(5) Degassing the paste preparation tank until the vacuum degree is between-0.095 Mpa and-0.100 Mpa, maintaining the vacuum degree of the paste preparation tank for 25min to 30min, opening a normal pressure valve, deflating a vacuum system of the paste preparation tank, and finally discharging paste to prepare the Chinese herbal medicine toothpaste with fresh breath.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116392410A (en) * | 2023-03-23 | 2023-07-07 | 段梅莉 | Functional toothpaste and preparation method thereof |
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| CN1184630A (en) * | 1997-11-26 | 1998-06-17 | 贾润之 | Tooth-paste for nourishing the heart to calm the mind, and method for preparing same |
| CN102525871A (en) * | 2012-03-13 | 2012-07-04 | 常熟华港制药有限公司 | Toothpaste for preventing and treating recurrent aphtha and preparation method |
| CN111228163A (en) * | 2019-09-17 | 2020-06-05 | 曲沃李时珍医药科技有限公司 | Halitosis-resisting toothpaste and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184630A (en) * | 1997-11-26 | 1998-06-17 | 贾润之 | Tooth-paste for nourishing the heart to calm the mind, and method for preparing same |
| CN102525871A (en) * | 2012-03-13 | 2012-07-04 | 常熟华港制药有限公司 | Toothpaste for preventing and treating recurrent aphtha and preparation method |
| CN111228163A (en) * | 2019-09-17 | 2020-06-05 | 曲沃李时珍医药科技有限公司 | Halitosis-resisting toothpaste and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116392410A (en) * | 2023-03-23 | 2023-07-07 | 段梅莉 | Functional toothpaste and preparation method thereof |
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Application publication date: 20221220 |