CN111218407B - 一株高产竹红菌素的竹黄菌及其培养方法和应用 - Google Patents
一株高产竹红菌素的竹黄菌及其培养方法和应用 Download PDFInfo
- Publication number
- CN111218407B CN111218407B CN202010040492.2A CN202010040492A CN111218407B CN 111218407 B CN111218407 B CN 111218407B CN 202010040492 A CN202010040492 A CN 202010040492A CN 111218407 B CN111218407 B CN 111218407B
- Authority
- CN
- China
- Prior art keywords
- hypocrellin
- culture
- fermentation
- strain
- tabasheer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- KGHNSNSWRMJVND-UHFFFAOYSA-N Hypocrellin Natural products COC1=CC(=O)C2=C3C4C(C(C(=O)C)C(C)(O)Cc5c(OC)c(O)c6C(=O)C=C(OC)C(=C13)c6c45)C(=C2O)OC KGHNSNSWRMJVND-UHFFFAOYSA-N 0.000 title claims abstract description 54
- VANSZAOQCMTTPB-SETSBSEESA-N hypocrellin Chemical compound C1[C@@](C)(O)[C@@H](C(C)=O)C2=C(OC)C(O)=C3C(=O)C=C(OC)C4=C3C2=C2C3=C4C(OC)=CC(=O)C3=C(O)C(OC)=C21 VANSZAOQCMTTPB-SETSBSEESA-N 0.000 title claims abstract description 54
- BQJKVFXDDMQLBE-UHFFFAOYSA-N shiraiachrome A Natural products COC1=C2C3=C(OC)C=C(O)C4=C3C3=C5C(CC(C)(O)C(C(C)=O)C3=C(OC)C4=O)=C(OC)C(=O)C(C(O)=C1)=C25 BQJKVFXDDMQLBE-UHFFFAOYSA-N 0.000 title claims abstract description 54
- 241000277045 Shiraia bambusicola Species 0.000 title claims abstract description 8
- 238000012136 culture method Methods 0.000 title abstract description 9
- 238000000855 fermentation Methods 0.000 claims abstract description 63
- 230000004151 fermentation Effects 0.000 claims abstract description 63
- SBMXTMAIKRQSQE-UHFFFAOYSA-N ac1lkrh1 Chemical compound O=C1C=C(OC)C2=C(C3=C45)C(OC)=CC(=O)C3=C(O)C(OC)=C4C(C(C)=O)=C(C)CC3=C5C2=C1C(O)=C3OC SBMXTMAIKRQSQE-UHFFFAOYSA-N 0.000 claims abstract description 60
- APTUSGMALOMQQL-UHFFFAOYSA-N Shiraiachrome C Natural products O=C1C(OC)=C2C(C(C)=O)=C(C)CC3=C(OC)C(=O)C4=C(O)C=C(OC)C5=C4C3=C2C2=C1C(O)=CC(OC)=C25 APTUSGMALOMQQL-UHFFFAOYSA-N 0.000 claims abstract description 30
- YDLBDQPPRTYAIG-UHFFFAOYSA-N hypocrellin A Natural products COC1C2CC(C)(O)C(C(=O)C)C3=C(OC)C(=O)c4c(O)cc(OC)c5c6c(OC)cc(O)c(C1=O)c6c2c3c45 YDLBDQPPRTYAIG-UHFFFAOYSA-N 0.000 claims abstract description 15
- UVHNWRDTZAYVST-UHFFFAOYSA-N hypocrellin D Natural products C1C(C)(O)C(C(C)=O)C2=C(OC)C(O)=C(C(=O)C=C(OC)C3=O)C3=C2C2=C(C(C(OC)=CC3=O)=O)C3=C(O)C(OC)=C21 UVHNWRDTZAYVST-UHFFFAOYSA-N 0.000 claims abstract description 15
- UVHNWRDTZAYVST-DJUQAAIZSA-N hypocrellin D Chemical compound C1[C@](C)(O)[C@H](C(C)=O)C2=C(OC)C(O)=C(C(=O)C=C(OC)C3=O)C3=C2C2=C(C(C(OC)=CC3=O)=O)C3=C(O)C(OC)=C21 UVHNWRDTZAYVST-DJUQAAIZSA-N 0.000 claims abstract description 15
- 241000233866 Fungi Species 0.000 claims abstract description 12
- 238000004321 preservation Methods 0.000 claims abstract description 6
- 238000009629 microbiological culture Methods 0.000 claims abstract description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 46
- 239000001963 growth medium Substances 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 26
- 244000061456 Solanum tuberosum Species 0.000 claims description 21
- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 21
- 238000011218 seed culture Methods 0.000 claims description 21
- 239000011780 sodium chloride Substances 0.000 claims description 21
- 238000002386 leaching Methods 0.000 claims description 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
- 235000007164 Oryza sativa Nutrition 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 12
- 235000009566 rice Nutrition 0.000 claims description 12
- 238000012258 culturing Methods 0.000 claims description 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 10
- 240000003915 Lophatherum gracile Species 0.000 claims description 9
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 9
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 9
- 241000196324 Embryophyta Species 0.000 claims description 8
- 229910000396 dipotassium phosphate Inorganic materials 0.000 claims description 8
- 239000002609 medium Substances 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 7
- CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 7
- 240000008042 Zea mays Species 0.000 claims description 6
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 6
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 6
- 235000005822 corn Nutrition 0.000 claims description 6
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 6
- 239000001888 Peptone Substances 0.000 claims description 5
- 108010080698 Peptones Proteins 0.000 claims description 5
- 229910001959 inorganic nitrate Inorganic materials 0.000 claims description 5
- 235000019319 peptone Nutrition 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- 235000016068 Berberis vulgaris Nutrition 0.000 claims description 4
- 241000335053 Beta vulgaris Species 0.000 claims description 4
- 240000003183 Manihot esculenta Species 0.000 claims description 4
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 claims description 4
- 239000000419 plant extract Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- 239000002207 metabolite Substances 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims 3
- 238000012262 fermentative production Methods 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 abstract description 3
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 12
- 235000017491 Bambusa tulda Nutrition 0.000 description 12
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 12
- 241001330002 Bambuseae Species 0.000 description 11
- 239000011425 bamboo Substances 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 241000209094 Oryza Species 0.000 description 9
- 235000012239 silicon dioxide Nutrition 0.000 description 9
- 241000288015 Bambusicola <bird> Species 0.000 description 8
- 239000000284 extract Substances 0.000 description 8
- 238000010563 solid-state fermentation Methods 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000001816 cooling Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- MVLVMROFTAUDAG-UHFFFAOYSA-N ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC MVLVMROFTAUDAG-UHFFFAOYSA-N 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 238000009736 wetting Methods 0.000 description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 3
- 229930091371 Fructose Natural products 0.000 description 3
- 239000005715 Fructose Substances 0.000 description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 230000003071 parasitic effect Effects 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 2
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 2
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 244000046052 Phaseolus vulgaris Species 0.000 description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 239000005862 Whey Substances 0.000 description 2
- 102000007544 Whey Proteins Human genes 0.000 description 2
- 108010046377 Whey Proteins Proteins 0.000 description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 229930182830 galactose Natural products 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 238000009630 liquid culture Methods 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000209128 Bambusa Species 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000173290 Cymbidium faberi Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000161991 Fargesia Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241001537207 Flammulina Species 0.000 description 1
- 240000006499 Flammulina velutipes Species 0.000 description 1
- 235000016640 Flammulina velutipes Nutrition 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 241000221775 Hypocreales Species 0.000 description 1
- 241000143667 Hypocrella Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010027145 Melanocytic naevus Diseases 0.000 description 1
- 206010050031 Muscle strain Diseases 0.000 description 1
- 208000007256 Nevus Diseases 0.000 description 1
- 240000002014 Phyllostachys nigra var. henonis Species 0.000 description 1
- 208000008765 Sciatica Diseases 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 241000212749 Zesius chrysomallus Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 231100000354 acute hepatitis Toxicity 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 206010002022 amyloidosis Diseases 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 230000001969 hypertrophic effect Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 208000002741 leukoplakia Diseases 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052603 melanterite Inorganic materials 0.000 description 1
- 206010062198 microangiopathy Diseases 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 125000001477 organic nitrogen group Chemical group 0.000 description 1
- IYYMDGDZPDXTGT-UHFFFAOYSA-N perylene-1,2-dione Chemical class C1=CC(C2=C3C(=CC(C2=O)=O)C=CC=C32)=C3C2=CC=CC3=C1 IYYMDGDZPDXTGT-UHFFFAOYSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000017983 photosensitivity disease Diseases 0.000 description 1
- 231100000434 photosensitization Toxicity 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010040492.2A CN111218407B (zh) | 2020-01-15 | 2020-01-15 | 一株高产竹红菌素的竹黄菌及其培养方法和应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010040492.2A CN111218407B (zh) | 2020-01-15 | 2020-01-15 | 一株高产竹红菌素的竹黄菌及其培养方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111218407A CN111218407A (zh) | 2020-06-02 |
CN111218407B true CN111218407B (zh) | 2020-12-08 |
Family
ID=70829494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010040492.2A Active CN111218407B (zh) | 2020-01-15 | 2020-01-15 | 一株高产竹红菌素的竹黄菌及其培养方法和应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111218407B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115851864A (zh) * | 2021-03-18 | 2023-03-28 | 华南理工大学 | 一种提高竹黄发酵生产苝醌类次生代谢物产量的方法 |
CN113233969A (zh) * | 2021-05-18 | 2021-08-10 | 山东国力生物科技有限公司 | 竹黄菌固态发酵物中提取竹红菌素的方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101168728A (zh) * | 2007-09-30 | 2008-04-30 | 江南大学 | 一株产苝醌化合物的竹黄菌株 |
CN101186932A (zh) * | 2007-11-11 | 2008-05-28 | 杨海龙 | 一种液体发酵法同时生产竹红菌素和竹黄多糖的方法 |
CN101875905A (zh) * | 2009-11-06 | 2010-11-03 | 首都师范大学 | 一株高产竹红菌素的毛竹种子内生真菌菌株及其应用 |
CN102703328A (zh) * | 2012-04-27 | 2012-10-03 | 苏州维因生物科技有限公司 | 一种高产竹红菌素的竹黄菌株 |
CN105925493A (zh) * | 2016-06-30 | 2016-09-07 | 南京工业大学 | 一株竹黄菌及其在发酵生产竹红菌素中的应用 |
CN110172409A (zh) * | 2019-04-26 | 2019-08-27 | 华南理工大学 | 一株高产竹红菌甲素的竹黄菌株及其应用 |
-
2020
- 2020-01-15 CN CN202010040492.2A patent/CN111218407B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101168728A (zh) * | 2007-09-30 | 2008-04-30 | 江南大学 | 一株产苝醌化合物的竹黄菌株 |
CN101186932A (zh) * | 2007-11-11 | 2008-05-28 | 杨海龙 | 一种液体发酵法同时生产竹红菌素和竹黄多糖的方法 |
CN101875905A (zh) * | 2009-11-06 | 2010-11-03 | 首都师范大学 | 一株高产竹红菌素的毛竹种子内生真菌菌株及其应用 |
CN102703328A (zh) * | 2012-04-27 | 2012-10-03 | 苏州维因生物科技有限公司 | 一种高产竹红菌素的竹黄菌株 |
CN105925493A (zh) * | 2016-06-30 | 2016-09-07 | 南京工业大学 | 一株竹黄菌及其在发酵生产竹红菌素中的应用 |
CN110172409A (zh) * | 2019-04-26 | 2019-08-27 | 华南理工大学 | 一株高产竹红菌甲素的竹黄菌株及其应用 |
Non-Patent Citations (1)
Title |
---|
竹黄无性型菌的人工培养研究;韩燕峰等;《食品工业科技》;20121231;第33卷(第14期);第2.3小节 * |
Also Published As
Publication number | Publication date |
---|---|
CN111218407A (zh) | 2020-06-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2005116187A1 (fr) | Procede de realisation d'une fermentation industrielle de champignons anamorphiques hirsutella hepiali chen et shen relatifs a cordyceps sinensis chinois | |
CN100406552C (zh) | 一株成团泛菌及其发酵培养方法与应用 | |
CN111218407B (zh) | 一株高产竹红菌素的竹黄菌及其培养方法和应用 | |
CN102351605A (zh) | 珍稀食药用菌绣球菌的液体发酵培养方法及其专用培养基 | |
CN110616156B (zh) | 哈茨木霉固态发酵培养基、哈茨木霉分生孢子以及包括该分生孢子的生物制剂及其应用 | |
CN103695336A (zh) | 改良对虾池塘底部生态环境的微生物制剂及制备方法 | |
CN113817615A (zh) | 一种利用双黄连药渣发酵生产的复合生防菌剂及其应用 | |
CN110423718A (zh) | 利用芽孢杆菌发酵液生产木霉菌厚垣孢子的方法及应用 | |
CN107801938B (zh) | 一种槟榔的生物软化方法 | |
CN113583914B (zh) | 一种防治草莓根腐病的微生物菌粉及其制备方法 | |
CN105670966B (zh) | 一株耐高温园林废弃物分解菌st4及其应用 | |
CN106479899B (zh) | 一种蛹虫草菌株及其在制备虫草素中的应用 | |
CN108795810A (zh) | 液固双相发酵生产生防解淀粉芽孢杆菌菌剂的方法 | |
CN112175871A (zh) | 一种万寿菊鲜花复合发酵剂及其应用 | |
CN111484368A (zh) | 一种微生物肥料固体发酵生产方法及固体复合微生物肥料 | |
CN108660092B (zh) | 一种含有乳酸菌发酵菊苣所得营养成分的苹果醋及苹果醋的生产工艺 | |
CN105567608B (zh) | 一株耐高温园林废弃物分解菌st1及其应用 | |
CN101861796B (zh) | 一种利用有色稻米发酵废糟培养豹斑毒鹅膏的方法 | |
CN111363692B (zh) | 一种复合菌剂及其发酵产物的应用 | |
CN106148214B (zh) | 一种圈卷产色链霉菌及制备尼可霉素的方法 | |
CN111548953A (zh) | 一种加速小麦秸秆发酵的微生物发酵菌剂及其制备方法 | |
CN108330087B (zh) | 一种用于发酵花生秸秆的固体发酵剂 | |
Okagbue | Fermentation research in Nigeria | |
CN100455654C (zh) | 耐高温的阿魏菇突变株 | |
CN101134940B (zh) | 一种中国冬虫夏草真菌-蝙蝠蛾被毛孢的发酵生产方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20240716 Address after: Room 1101, Building 2, Xinsheng Building, No. 1299 Xinluo Street, Jinan Area, China (Shandong) Pilot Free Trade Zone, Jinan City, Shandong Province, China 250098 Patentee after: Shandong Yuanhe Biological Engineering Co.,Ltd. Country or region after: China Patentee after: Shandong National Biotechnology Research Institute Address before: 250100 1101, building 2, Xinsheng building, 1299 Xinluo street, high tech Zone, Jinan City, Shandong Province Patentee before: Shandong Guoli biological science and Technology Co.,Ltd. Country or region before: China Patentee before: Shandong National Biotechnology Research Institute |
|
TR01 | Transfer of patent right |