CN111197046A - Notch 1特异性sirna分子 - Google Patents

Notch 1特异性sirna分子 Download PDF

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Publication number
CN111197046A
CN111197046A CN202010081100.7A CN202010081100A CN111197046A CN 111197046 A CN111197046 A CN 111197046A CN 202010081100 A CN202010081100 A CN 202010081100A CN 111197046 A CN111197046 A CN 111197046A
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nucleotides
cancer
nucleic acid
nucleotide
strand
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Chinese (zh)
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S·施赖伯
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Soluventis GmbH
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Soluventis GmbH
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    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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CN202010081100.7A 2013-09-30 2014-09-30 Notch 1特异性sirna分子 Pending CN111197046A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13004722.8A EP2853595A1 (en) 2013-09-30 2013-09-30 NOTCH 1 specific siRNA molecules
EP13004722.8 2013-09-30
CN201480061599.8A CN105814202B (zh) 2013-09-30 2014-09-30 Notch1特异性sirna分子

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480061599.8A Division CN105814202B (zh) 2013-09-30 2014-09-30 Notch1特异性sirna分子

Publications (1)

Publication Number Publication Date
CN111197046A true CN111197046A (zh) 2020-05-26

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ID=49304652

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202010081100.7A Pending CN111197046A (zh) 2013-09-30 2014-09-30 Notch 1特异性sirna分子
CN201480061599.8A Expired - Fee Related CN105814202B (zh) 2013-09-30 2014-09-30 Notch1特异性sirna分子

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201480061599.8A Expired - Fee Related CN105814202B (zh) 2013-09-30 2014-09-30 Notch1特异性sirna分子

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US (2) US9896690B2 (enExample)
EP (2) EP2853595A1 (enExample)
JP (2) JP6561061B2 (enExample)
CN (2) CN111197046A (enExample)
AU (1) AU2014327809B2 (enExample)
CA (1) CA2924788A1 (enExample)
DK (1) DK3052625T3 (enExample)
HR (1) HRP20211525T1 (enExample)
HU (1) HUE056609T2 (enExample)
IL (1) IL244661B (enExample)
LT (1) LT3052625T (enExample)
MX (1) MX377713B (enExample)
RU (1) RU2651493C2 (enExample)
SG (2) SG10201802593WA (enExample)
SI (1) SI3052625T1 (enExample)
WO (1) WO2015043768A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2853595A1 (en) * 2013-09-30 2015-04-01 Soluventis GmbH NOTCH 1 specific siRNA molecules
JP7737708B2 (ja) * 2019-12-27 2025-09-11 国立大学法人神戸大学 癌遺伝子治療薬
CN112626068B (zh) * 2020-12-21 2021-12-03 徐州医科大学 一种靶向Notch1基因的LncRNA及其应用
CN116790603B (zh) * 2023-08-18 2023-10-31 成都中科奥格生物科技有限公司 一种sgRNA、CRISPR/Cas9载体及其构建方法和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110105588A1 (en) * 2008-03-12 2011-05-05 Intradigm Corporation Compositions comprising notch1 sirna and methods of use thereof
CN102112109A (zh) * 2008-05-19 2011-06-29 塞尔闻缇斯集团 用于基因传递的具有增强内吞作用的表面的全氟化碳纳米乳液
WO2013020097A1 (en) * 2011-08-03 2013-02-07 Quark Pharmaceuticals, Inc. Double-stranded oligonucleotide compounds for treating hearing and balance disorders

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JPH07509133A (ja) 1992-07-17 1995-10-12 リボザイム・ファーマシューティカルズ・インコーポレイテッド 動物疾患の処置のための方法および剤
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US5753613A (en) 1994-09-30 1998-05-19 Inex Pharmaceuticals Corporation Compositions for the introduction of polyanionic materials into cells
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US6001311A (en) 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
US6395713B1 (en) 1997-07-23 2002-05-28 Ribozyme Pharmaceuticals, Inc. Compositions for the delivery of negatively charged molecules
WO1999054459A2 (en) 1998-04-20 1999-10-28 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
ATE408699T1 (de) 1999-03-10 2008-10-15 Phogen Ltd Verabreichung von nukleinsäuren und proteinen an zellen
KR101201664B1 (ko) 2002-08-05 2012-11-15 사일런스 테라퓨틱스 아게 신규한 형태의 간섭 rna 분자
HUE036916T2 (hu) 2004-05-05 2018-08-28 Silence Therapeutics Gmbh Lipidek, lipid komplexek és ezek alkalmazása
AU2009209571A1 (en) * 2008-01-29 2009-08-06 Proyecto De Biomedicina Cima, S.L. Methods and compositions capable of causing post-transcriptional silencing of gene expression in a synergic manner
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EP2802657B1 (en) * 2012-01-12 2018-05-02 Quark Pharmaceuticals, Inc. Combination therapy for treating hearing and balance disorders
EP2853595A1 (en) * 2013-09-30 2015-04-01 Soluventis GmbH NOTCH 1 specific siRNA molecules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110105588A1 (en) * 2008-03-12 2011-05-05 Intradigm Corporation Compositions comprising notch1 sirna and methods of use thereof
CN102112109A (zh) * 2008-05-19 2011-06-29 塞尔闻缇斯集团 用于基因传递的具有增强内吞作用的表面的全氟化碳纳米乳液
WO2013020097A1 (en) * 2011-08-03 2013-02-07 Quark Pharmaceuticals, Inc. Double-stranded oligonucleotide compounds for treating hearing and balance disorders

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G. PAOLO DOTTO: ""Notch tumor suppressor function"", 《ONCOGENE》 *
刘虹: ""靶向Notch1 基因的siRNA 对裸鼠人肝细胞癌移植瘤细胞增殖和凋亡的影响"", 《中国现代医学杂志》 *

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WO2015043768A8 (en) 2016-05-12
JP2016533190A (ja) 2016-10-27
MX377713B (es) 2025-03-11
AU2014327809B2 (en) 2021-11-18
EP3052625B1 (en) 2021-08-25
DK3052625T3 (da) 2021-11-15
MX2016004142A (es) 2016-10-13
US10669548B2 (en) 2020-06-02
JP6561061B2 (ja) 2019-08-14
JP7086039B2 (ja) 2022-06-17
SG10201802593WA (en) 2018-05-30
CN105814202B (zh) 2020-03-06
US20180237785A1 (en) 2018-08-23
LT3052625T (lt) 2021-12-10
RU2651493C2 (ru) 2018-04-19
CA2924788A1 (en) 2015-04-02
CN105814202A (zh) 2016-07-27
WO2015043768A1 (en) 2015-04-02
EP2853595A1 (en) 2015-04-01
US20160215292A1 (en) 2016-07-28
RU2016116931A (ru) 2017-11-10
HUE056609T2 (hu) 2022-02-28
IL244661B (en) 2021-08-31
AU2014327809A1 (en) 2016-04-07
JP2019196384A (ja) 2019-11-14
IL244661A0 (en) 2016-04-21
SI3052625T1 (sl) 2021-12-31
EP3052625A1 (en) 2016-08-10
HRP20211525T1 (hr) 2021-12-24
US9896690B2 (en) 2018-02-20
SG11201602437VA (en) 2016-04-28

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