CN111184787A - Method for preparing dried orange peel extract - Google Patents
Method for preparing dried orange peel extract Download PDFInfo
- Publication number
- CN111184787A CN111184787A CN201811357182.2A CN201811357182A CN111184787A CN 111184787 A CN111184787 A CN 111184787A CN 201811357182 A CN201811357182 A CN 201811357182A CN 111184787 A CN111184787 A CN 111184787A
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- China
- Prior art keywords
- orange peel
- dried orange
- raw material
- carbon dioxide
- peel extract
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pulmonology (AREA)
- Botany (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Microbiology (AREA)
- Disintegrating Or Milling (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a method for preparing a dried orange peel extract. The processing steps comprise: adding dried orange peel into a pulverizer to be pulverized into 80 meshes, introducing the pulverized dried orange peel into a raw material mixing tank from a raw material tank, gradually pressurizing carbon dioxide to 150-.
Description
The technical field is as follows:
the invention relates to a method for preparing a dried orange peel extract, belonging to the technical field of extraction and separation of active ingredients of natural products.
Background art:
the pericarpium Citri Tangerinae is dried mature pericarp of Rutaceae plant fructus Citri Tangerinae and its cultivar. The medicinal materials are classified into pericarpium citri reticulatae and pericarpium citri reticulatae. Picking mature fruit, peeling peel, and drying in the sun or at low temperature. The peel is usually peeled into a plurality of sections, the base parts are connected, and some sections are irregular and have the thickness of 1-4 mm. The outer surface is orange red or reddish brown, and has fine wrinkles and concave punctate oil chambers; the inner surface is pale yellowish white and coarse, and is attached with yellowish white or yellowish brown tendon-like vascular bundles. The texture is slightly hard and brittle. Fragrant, pungent and bitter.
The dried orange peel extract regulates qi, strengthens spleen, eliminates dampness and reduces phlegm. Can be used for treating fullness in chest and abdomen, anorexia, vomiting, diarrhea, cough, and excessive phlegm. It is combined with cang Zhu and Hou Po to treat gastric and abdominal distention and pain, nausea, vomiting and diarrhea due to cold-dampness in middle energizer and qi stagnation in spleen and stomach. It is combined with shan Zha and Shen Qu for food stagnation, qi stagnation and distending pain in stomach and abdomen. It is combined with Zhi Shi and Sheng Jiang for chest stuffiness and shortness of breath.
In the prior art, the extraction and separation method of the dried orange peel extract mainly adopts an organic solvent method and the like, but the traditional methods can not effectively extract the effective components of the traditional Chinese medicine, and destroy most of heat-sensitive substances in the effective components, so that the efficacy is reduced, and the utilization efficiency is extremely low.
In order to overcome the technical defects, the invention adopts a multi-effect wall breaking method to extract raw materials, adopts an ultrahigh pressure supercritical micro-jet technology, integrates the characteristics of the ultrahigh pressure technology, the supercritical extraction technology and an impinging stream technology, has high extraction efficiency and short time, and realizes continuous production by feeding and discharging materials at the same time.
The invention content is as follows:
the invention aims to provide a method for extracting a dried orange peel extract by multi-effect wall breaking through an ultrahigh pressure technology, a supercritical extraction technology and an impinging stream technology aiming at the defects of the prior art so as to obtain the dried orange peel extract with high quality.
The invention comprises the following steps:
a. adding pericarpium Citri Tangerinae into a pulverizer, and pulverizing with 80 mesh;
b. introducing the crushed dried orange peel into a raw material mixing tank from a raw material tank, gradually pressurizing carbon dioxide to 150-;
c. the mixed fluid of the dried orange peel raw material and the supercritical carbon dioxide is quickly sprayed out from a nozzle and is impacted with a target in an impact flow crusher;
d. breaking cell wall of raw materials, and separating with carbon dioxide in a separating tank to obtain the final product.
And c, mixing the carbon dioxide and the dried orange peel raw material in the step b, and keeping the pressure for 1-1.5 h.
And c, impacting the target in the impact flow crusher, wherein the target distance is 10-20 mm.
The present invention will be further described with reference to specific embodiments, but the scope of the invention as claimed is not limited to the following embodiments.
The specific implementation mode is as follows:
example 1:
adding pericarpium Citri Tangerinae into a pulverizer, pulverizing by 80 mesh, introducing pulverized pericarpium Citri Tangerinae into a raw material mixing tank from a raw material tank, gradually pressurizing carbon dioxide to 150 deg.C by an inverted steel cylinder via a pneumatic pump, mixing with pericarpium Citri Tangerinae raw material in the raw material mixing tank, adjusting the temperature in the raw material mixing tank to 50 deg.C, maintaining the pressure for 1 hr, rapidly spraying mixed fluid of pericarpium Citri Tangerinae raw material and supercritical carbon dioxide from a nozzle, impacting with a target in an impact flow pulverizer, wherein the target distance is 10mm, breaking cell wall of the raw material, separating with carbon dioxide in a separation tank to obtain the final product with content of 99.55% by UV detection.
Example 2:
adding pericarpium Citri Tangerinae into a pulverizer, pulverizing by 80 mesh, introducing pulverized pericarpium Citri Tangerinae into a raw material mixing tank from a raw material tank, gradually pressurizing carbon dioxide to 250 deg.C by an inverted steel cylinder via a pneumatic pump, mixing with pericarpium Citri Tangerinae raw material in the raw material mixing tank, adjusting the temperature in the raw material mixing tank to 60 deg.C, maintaining the pressure for 1.5 hr, rapidly spraying mixed fluid of pericarpium Citri Tangerinae raw material and supercritical carbon dioxide from a nozzle, impacting with a target in an impact flow pulverizer, wherein the target distance is 20mm, breaking cell wall of the raw material, separating with carbon dioxide in a separation tank to obtain the final product with content of 99.85% by UV detection.
Example 3:
adding pericarpium Citri Tangerinae into a pulverizer, pulverizing by 80 mesh, introducing pulverized pericarpium Citri Tangerinae into a raw material mixing tank from a raw material tank, gradually pressurizing carbon dioxide to 200 deg.C by an inverted steel cylinder via a pneumatic pump, mixing with pericarpium Citri Tangerinae raw material in the raw material mixing tank, adjusting the temperature in the raw material mixing tank to 50 deg.C, maintaining the pressure for 1 hr, rapidly spraying mixed fluid of pericarpium Citri Tangerinae raw material and supercritical carbon dioxide from a nozzle, impacting with a target in an impact flow pulverizer, wherein the target distance is 10mm, breaking cell wall of the raw material, separating with carbon dioxide in a separation tank to obtain the final product with content of 99.65% by UV detection.
Claims (3)
1. A method for preparing a dried orange peel extract is characterized by comprising the following steps:
a. adding pericarpium Citri Tangerinae into a pulverizer, and pulverizing with 80 mesh;
b. introducing the crushed dried orange peel into a raw material mixing tank from a raw material tank, gradually pressurizing carbon dioxide to 150-;
c. the mixed fluid of the dried orange peel raw material and the supercritical carbon dioxide is quickly sprayed out from a nozzle and is impacted with a target in an impact flow crusher;
d. breaking cell wall of raw materials, and separating with carbon dioxide in a separating tank to obtain the final product.
2. The method for extracting the dried orange peel extract by multi-effect wall breaking according to claim 1, wherein the pressure is maintained for 1-1.5h after the carbon dioxide is mixed with the dried orange peel raw material in the step b.
3. The method for extracting the dried orange peel extract by multi-effect wall breaking as claimed in claim 1, wherein the step c is performed by impacting a target with an impact flow pulverizer at a target distance of 10-20 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811357182.2A CN111184787A (en) | 2018-11-15 | 2018-11-15 | Method for preparing dried orange peel extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811357182.2A CN111184787A (en) | 2018-11-15 | 2018-11-15 | Method for preparing dried orange peel extract |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111184787A true CN111184787A (en) | 2020-05-22 |
Family
ID=70684182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811357182.2A Withdrawn CN111184787A (en) | 2018-11-15 | 2018-11-15 | Method for preparing dried orange peel extract |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111184787A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113578482A (en) * | 2021-07-27 | 2021-11-02 | 康道生物（南通）有限公司 | Ganoderma lucidum spore powder wall breaking processing technology |
-
2018
- 2018-11-15 CN CN201811357182.2A patent/CN111184787A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113578482A (en) * | 2021-07-27 | 2021-11-02 | 康道生物（南通）有限公司 | Ganoderma lucidum spore powder wall breaking processing technology |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20200522 |
|
| WW01 | Invention patent application withdrawn after publication |