CN111184741A - Preparation method of biological agent for treating virus infected person, related biological agent and application - Google Patents
Preparation method of biological agent for treating virus infected person, related biological agent and application Download PDFInfo
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- CN111184741A CN111184741A CN202010104731.6A CN202010104731A CN111184741A CN 111184741 A CN111184741 A CN 111184741A CN 202010104731 A CN202010104731 A CN 202010104731A CN 111184741 A CN111184741 A CN 111184741A
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- 241000700605 Viruses Species 0.000 title claims abstract description 87
- 239000003124 biologic agent Substances 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title abstract description 22
- 210000002966 serum Anatomy 0.000 claims abstract description 66
- 210000004369 blood Anatomy 0.000 claims abstract description 62
- 239000008280 blood Substances 0.000 claims abstract description 62
- 241001465754 Metazoa Species 0.000 claims abstract description 43
- 238000000034 method Methods 0.000 claims abstract description 15
- 230000000840 anti-viral effect Effects 0.000 claims abstract description 13
- 241000287828 Gallus gallus Species 0.000 claims description 24
- 210000003462 vein Anatomy 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 10
- 210000001099 axilla Anatomy 0.000 claims description 6
- 241000288900 Desmodus rotundus Species 0.000 claims description 3
- 241000711573 Coronaviridae Species 0.000 claims 1
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- 241000282414 Homo sapiens Species 0.000 abstract description 21
- 238000013461 design Methods 0.000 abstract description 7
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- 235000013330 chicken meat Nutrition 0.000 description 23
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 230000002354 daily effect Effects 0.000 description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 8
- 244000144977 poultry Species 0.000 description 7
- 235000013594 poultry meat Nutrition 0.000 description 7
- 241000288673 Chiroptera Species 0.000 description 6
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- 229910052742 iron Inorganic materials 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 3
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
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- 244000144972 livestock Species 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241001115402 Ebolavirus Species 0.000 description 1
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- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
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- 229960005224 roxithromycin Drugs 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 206010048282 zoonosis Diseases 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
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- Engineering & Computer Science (AREA)
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- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
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- Oncology (AREA)
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Abstract
The invention provides a preparation method of a biological agent for treating a virus infected person, which comprises the following steps: (1) taking out virus-carrying blood of bat, inactivating virus at high temperature, and separating and purifying blood serum; (2) injecting the serum into the body of a healthy animal daily until antibodies to the virus are produced in the body of the healthy animal; (3) taking out blood of healthy animals, and separating and purifying serum of the blood of the healthy animals to obtain antiviral serum, wherein the antiviral serum is a biological agent for treating virus infected persons. Also provides a biological agent prepared by the method for treating virus infected persons and application thereof. The biological agent for treating the virus infected person, which is prepared by the preparation method of the biological agent for treating the virus infected person, can treat the virus infected person, thereby promoting the physical rehabilitation of people, saving the human life, having the advantages of ingenious design, simple and convenient operation and low cost, and being suitable for large-scale popularization and application.
Description
Technical Field
The invention relates to the technical field of biological medicines, in particular to the technical field of biological agents for treating virus infected persons, and particularly relates to a preparation method of a biological agent for treating virus infected persons, a related biological agent and application.
Background
The bat is the only mammal capable of flying by flapping wings, and the habits of the bat are that the bat takes a rest in a dark and humid cave in the daytime and the bat is eaten at night.
In China, bats mainly live in mountainous areas or karst caves in the south, generally do not attack human beings, are hosts of a large number of zoonosis, and are presumed by experts that more than 200 viruses are parasitic in the bats, so that the bats can quickly have severe acute respiratory diseases (SARS), hennepa virus and Ebola virus after being infected by human and livestock. In the bat population, the common bats are harmonious with human beings and livestock and poultry without mutual interference, but only the blood sucking bats are hosts for spreading viruses, the habits of the blood sucking bats in diet live by the blood of sucking animals and human beings, a large amount of poultry breeding is carried out by utilizing forests in mountain areas at present, which provides food sources for the blood sucking bats, when the blood sucking bat sucks the blood of the poultry or the animal at the wound after biting the meat of the poultry or the animal, various viruses living in the bat mouth naturally enter the bodies of the poultry or the animals, when the poultry and other animals are in the half-death stage, farmers sell the virus to merchants, and the virus also enters human beings, and during the process of hunting, transporting and killing the wild flavor, it is also exposed to viruses, which spread throughout the human population once they have achieved transmission from animals to humans.
Therefore, in order to treat a virus infected person, it is desirable to provide a biological agent for treating a virus infected person, which can treat a virus infected person, thereby promoting physical rehabilitation of people and saving human lives.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention aims to provide a preparation method of a biological agent for treating a virus infected person, and the biological agent for treating the virus infected person prepared by the method can treat the virus infected person, so that the physical rehabilitation of people is promoted, the human life is saved, and the biological agent is suitable for large-scale popularization and application.
The invention also aims to provide a preparation method of the biological agent for treating virus infected persons, which has the advantages of ingenious design, simple and convenient operation and low cost and is suitable for large-scale popularization and application.
The invention also aims to provide a biological agent for treating virus infected persons, which can treat the virus infected persons, thereby promoting the physical rehabilitation of people, saving human lives and being suitable for large-scale popularization and application.
The invention also aims to provide a biological agent for treating virus infected persons, which has the advantages of ingenious design, simple and convenient preparation and low cost, and is suitable for large-scale popularization and application.
The invention also aims to provide application of the biological agent for treating virus infected persons, which can be used as a medicament for treating virus infected persons, thereby promoting physical rehabilitation of people, saving human lives and being suitable for large-scale popularization and application.
The invention also aims to provide application of the biological agent for treating virus infectors, which has the advantages of ingenious design, simple and convenient use and low cost and is suitable for large-scale popularization and application.
In order to achieve the above object, in a first aspect of the present invention, there is provided a method for preparing a biological agent for treating a person infected with a virus, comprising the steps of:
(1) taking out the blood with virus of bat, placing the blood at high temperature to inactivate the virus, and separating and purifying the serum of the blood;
(2) injecting the serum into the body of a healthy animal daily until antibodies to the virus are produced in the body of the healthy animal;
(3) taking out the blood of the healthy animal, and separating and purifying the serum of the blood of the healthy animal, wherein the serum of the blood of the healthy animal is antiviral serum, and the antiviral serum is a biological agent for treating virus infected persons.
Preferably, in the step (1), the bat is a vampire bat.
Preferably, in the step (1), the blood is taken out from a vein of the bat.
More preferably, in the step (1), the vein is a vein under an axilla of the bat.
Preferably, in the step (1), the high temperature is 50 ℃ to 60 ℃.
Preferably, in said step (2), 5 g of said serum is injected daily for the first to second days, 10 g of said serum is injected daily for the third to fifth days, 15 g of said serum is injected for the sixth day, and whether or not said antibody is produced is determined after the seventh day.
Preferably, in the step (2), the healthy animal is a chicken.
In a second aspect of the present invention, there is provided a biological agent for treating a patient infected with a virus, which is characterized by being prepared by the above-mentioned method for preparing a biological agent for treating a patient infected with a virus.
In a third aspect of the invention, there is provided the use of a biological agent for the treatment of a subject infected with a virus, in a medicament for the treatment of a subject infected with a virus.
Preferably, the virus-infected person is a coronavirus-infected person.
The invention has the beneficial effects that:
1. the preparation method of the biological agent for treating virus infected persons comprises the following steps: (1) taking out virus-carrying blood of bat, inactivating virus at high temperature, and separating and purifying blood serum; (2) injecting the serum into the body of a healthy animal daily until antibodies to the virus are produced in the body of the healthy animal; (3) the blood of the healthy animal is taken out, and then the serum of the blood of the healthy animal is separated and purified, wherein the serum of the blood of the healthy animal is the anti-virus serum, and the anti-virus serum is the biological agent for treating the virus infected person.
2. The preparation method of the biological agent for treating virus infected persons comprises the following steps: (1) taking out virus-carrying blood of bat, inactivating virus at high temperature, and separating and purifying blood serum; (2) injecting the serum into the body of a healthy animal daily until antibodies to the virus are produced in the body of the healthy animal; (3) the blood of the healthy animal is taken out, and then the serum of the blood of the healthy animal is separated and purified, wherein the serum of the blood of the healthy animal is the anti-virus serum, and the anti-virus serum is the biological agent for treating virus infected persons.
3. The biological preparation for treating the virus infected person is prepared by the preparation method of the biological preparation for treating the virus infected person, so that the biological preparation can treat the virus infected person, thereby promoting the physical rehabilitation of people, saving the life of human beings and being suitable for large-scale popularization and application.
4. The biological preparation for treating the virus infected person is prepared by the preparation method of the biological preparation for treating the virus infected person, so the biological preparation is ingenious in design, simple and convenient to prepare, low in cost and suitable for large-scale popularization and application.
5. The biological agent for treating the virus infected person is applied to the medicine for treating the virus infected person, so that the biological agent can be used as the medicine for treating the virus infected person, thereby promoting the physical rehabilitation of people, saving the human life and being suitable for large-scale popularization and application.
6. The biological agent for treating the virus infected person is applied to the medicine for treating the virus infected person, so the biological agent is ingenious in design, simple and convenient to use, low in cost and suitable for large-scale popularization and application.
These and other objects, features and advantages of the present invention will become more fully apparent from the following detailed description, and are achieved by means of the instrumentalities, devices and combinations particularly pointed out in the appended claims.
Detailed Description
In order to prevent the harm of the blood-sucking bat to human being brought by poultry and wild animals, the present inventors invented a medicament for controlling infection of human being by injecting serum of blood of bat into the body of healthy animal to obtain antiviral serum.
Specifically, the invention firstly provides a preparation method of a biological agent for treating a virus infected person, which comprises the following steps:
(1) taking out the blood with virus of bat, placing the blood at high temperature to inactivate the virus, and separating and purifying the serum of the blood;
(2) injecting the serum into the body of a healthy animal daily until antibodies to the virus are produced in the body of the healthy animal;
(3) taking out the blood of the healthy animal, and separating and purifying the serum of the blood of the healthy animal, wherein the serum of the blood of the healthy animal is antiviral serum, and the antiviral serum is a biological agent for treating virus infected persons.
In the step (1), the bat may be any suitable bat, and preferably, in the step (1), the bat is a vampire bat.
In said step (1), said blood is taken out from any suitable tissue of said bat, preferably, in said step (1), said blood is taken out from a vein of said bat.
In the step (1), the vein may be a vein of any suitable location of the bat, more preferably, in the step (1), the vein is a vein under an axilla of the bat.
In the step (1), the high temperature may be determined as required, and preferably, in the step (1), the high temperature is 50 ℃ to 60 ℃.
In the step (2), the serum may be injected into the body of a healthy animal daily at any suitable dose, and preferably, in the step (2), 5 g of the serum is injected daily on the first day to the second day, 10 g of the serum is injected daily on the third day to the fifth day, 15 g of the serum is injected on the sixth day, and whether the antibody is produced or not is detected after the seventh day.
In step (2), the healthy animal may be any suitable animal, and preferably, in step (2), the healthy animal is a chicken.
Chicken blood: pungent, neutral, salty and nontoxic in flavor and enter heart and liver meridians. The chicken blood has high iron content and exists in the form of heme iron, and is easily absorbed and utilized by human bodies. The chicken blood contains thrombin, which can make fibrin in blood sol state quickly generate insoluble fibrin to coagulate the blood, thus having hemostatic effect. The chicken blood can also provide high-quality protein and a plurality of trace elements for human bodies, and the research in recent years shows that the chicken blood has certain curative effect on bronchitis and the like.
The invention also provides a biological agent for treating virus infected persons, which is prepared by the preparation method of the biological agent for treating virus infected persons.
The invention also provides the use of a biological agent for treating a person infected with a virus in a medicament for treating a person infected with a virus.
The virus-infected person may be any suitable virus-infected person, preferably, the virus-infected person is a coronavirus-infected person.
Example 1
1. Blood with virus is taken from the veins under the axilla of the bat, the blood is put into a constant temperature box to kill the virus at a high temperature of 56 ℃, and then serum is separated and purified.
2. Injecting inactivated bat serum with 5 g once a day into healthy adult chicken, increasing the amount to 10 g every day after two days for injection, wherein the injection time is three days, stopping injection after increasing the amount to 15 g in the sixth day, detecting whether the chicken generates antibodies in a week, and if the chicken generates antibodies, drawing blood to prepare serum for later use.
3. The antiviral serum is obtained by separating serum from chicken blood and purifying.
Example 2
1. Blood with virus is taken from the veins under the axilla of the bat, the blood is put into a constant temperature box to kill the virus at a high temperature of 50 ℃, and then serum is separated and purified.
2. Injecting inactivated bat serum with 5 g once a day into healthy adult chicken, increasing the amount to 10 g every day after two days for injection, wherein the injection time is three days, stopping injection after increasing the amount to 15 g in the sixth day, detecting whether the chicken generates antibodies in a week, and if the chicken generates antibodies, drawing blood to prepare serum for later use.
3. The antiviral serum is obtained by separating serum from chicken blood and purifying.
Example 3
1. Blood with virus is taken from the veins under the axilla of the bat, the blood is put into a constant temperature box to kill the virus at a high temperature of 60 ℃, and then serum is separated and purified.
2. Injecting inactivated bat serum with 5 g once a day into healthy adult chicken, increasing the amount to 10 g every day after two days for injection, wherein the injection time is three days, stopping injection after increasing the amount to 15 g in the sixth day, detecting whether the chicken generates antibodies in a week, and if the chicken generates antibodies, drawing blood to prepare serum for later use.
3. The antiviral serum is obtained by separating serum from chicken blood and purifying.
The biological agent of the invention is heterogeneous serum, has anaphylactic reaction to human, and needs skin test before injection. Negative injectability and positive desensitization therapy is required. The serum contains a large amount of antibodies, and after the serum is injected into a human body, the human body can obtain immunity without self-manufacturing the antibodies.
The main functions are as follows: can be used for treating bat infected by any virus.
The using method comprises the following steps: it is recommended to start the use in the early stage of the infected person, and the dosage is as follows: 1ml/5 kg body weight-2 ml/5 kg body weight, 1 time per day, three times for continuous use, can increase injection frequency for severe patients, and has better effect when used together with antibiotics such as roxithromycin and the like, traditional Chinese medicine of golden buckwheat rhizome and indigowoad root concentrated water.
The artificial passive immunization method of bat serum uses chickens as a test body because the main object of bat blood absorption is chickens. The chicken blood contains a bacteriostatic peptide component which can kill viruses, particularly various viruses in bat bodies, has broad-spectrum antiviral property, has high iron content in the chicken blood, exists in the form of heme iron and is easily absorbed and utilized by human bodies.
In conclusion, the biological agent for treating the virus infected person prepared by the preparation method of the biological agent for treating the virus infected person can treat the virus infected person, so that the body rehabilitation of people is promoted, the life of people is saved, the design is ingenious, the operation is simple and convenient, the cost is low, and the preparation method is suitable for large-scale popularization and application.
In this specification, the invention has been described with reference to specific embodiments thereof. It will, however, be evident that various modifications and changes may be made thereto without departing from the broader spirit and scope of the invention. The description is thus to be regarded as illustrative instead of limiting.
Claims (10)
1. A method of preparing a biological agent for treating a subject infected with a virus, comprising the steps of:
(1) taking out the blood with virus of bat, placing the blood at high temperature to inactivate the virus, and separating and purifying the serum of the blood;
(2) injecting the serum into the body of a healthy animal daily until antibodies to the virus are produced in the body of the healthy animal;
(3) taking out the blood of the healthy animal, and separating and purifying the serum of the blood of the healthy animal, wherein the serum of the blood of the healthy animal is antiviral serum, and the antiviral serum is a biological agent for treating virus infected persons.
2. The method for preparing a biological agent for treating a viral infected person as claimed in claim 1, wherein, in the step (1), the bat is a vampire bat.
3. The method for preparing a biological agent for treating a virus infected person as claimed in claim 1, wherein, in the step (1), the blood is taken out from the vein of the bat.
4. The method for preparing a biological agent for treating a person infected with a virus according to claim 3, wherein, in the step (1), the vein is a vein under axilla of limbs of the bat.
5. The method of claim 1, wherein the elevated temperature in step (1) is 50 ℃ to 60 ℃.
6. The method of claim 1, wherein in step (2), 5 g of the serum is injected daily for the first to second days, 10 g of the serum is injected daily for the third to fifth days, 15 g of the serum is injected for the sixth day, and whether or not the antibody is produced is determined after the seventh day.
7. The method of claim 1, wherein in step (2), the healthy animal is a chicken.
8. A biological agent for treating a virus-infected person, which is prepared by the method for preparing a biological agent for treating a virus-infected person according to any one of claims 1 to 7.
9. Use of a biological agent according to claim 8 for the treatment of a virally infected person in a medicament for the treatment of a virally infected person.
10. The use of claim 9, wherein the virally infected person is a coronavirus infected person.
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| CN202010104731.6A CN111184741A (en) | 2020-02-20 | 2020-02-20 | Preparation method of biological agent for treating virus infected person, related biological agent and application |
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| Application Number | Priority Date | Filing Date | Title |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546172A (en) * | 2003-11-28 | 2004-11-17 | 陆家海 | Hyper-immune serum for resisting SARS virus and its preparation |
| CN101422485A (en) * | 2008-08-15 | 2009-05-06 | 中国农业科学院特产研究所 | Preparation method of spleen byproducts for producing homology anti-serum blood and transfer factor from fox, raccoon dog, mink |
| CN105777898A (en) * | 2016-05-09 | 2016-07-20 | 福州大北农生物技术有限公司 | Preparation method for swine influenza positive serum |
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2020
- 2020-02-20 CN CN202010104731.6A patent/CN111184741A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546172A (en) * | 2003-11-28 | 2004-11-17 | 陆家海 | Hyper-immune serum for resisting SARS virus and its preparation |
| CN101422485A (en) * | 2008-08-15 | 2009-05-06 | 中国农业科学院特产研究所 | Preparation method of spleen byproducts for producing homology anti-serum blood and transfer factor from fox, raccoon dog, mink |
| CN105777898A (en) * | 2016-05-09 | 2016-07-20 | 福州大北农生物技术有限公司 | Preparation method for swine influenza positive serum |
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