CN111163771B - 嘧啶并嘧啶酮类作为sik抑制剂的用途 - Google Patents

嘧啶并嘧啶酮类作为sik抑制剂的用途 Download PDF

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CN111163771B
CN111163771B CN201880027619.8A CN201880027619A CN111163771B CN 111163771 B CN111163771 B CN 111163771B CN 201880027619 A CN201880027619 A CN 201880027619A CN 111163771 B CN111163771 B CN 111163771B
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CN111163771A (zh
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D.E.菲舍尔
N.穆贾希德
N.S.格雷
梁焱科
村上亮
崔焕根
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General Hospital Corp
Dana Farber Cancer Institute Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201880027619.8A 2017-02-28 2018-02-28 嘧啶并嘧啶酮类作为sik抑制剂的用途 Active CN111163771B (zh)

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Application Number Priority Date Filing Date Title
US201762464675P 2017-02-28 2017-02-28
US62/464,675 2017-02-28
US201762472468P 2017-03-16 2017-03-16
US62/472,468 2017-03-16
PCT/US2018/020335 WO2018160774A1 (en) 2017-02-28 2018-02-28 Uses of pyrimidopyrimidinones as sik inhibitors

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CN111163771A CN111163771A (zh) 2020-05-15
CN111163771B true CN111163771B (zh) 2023-07-14

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US (3) US11285158B2 (https=)
EP (1) EP3589284A4 (https=)
JP (2) JP7296318B2 (https=)
KR (1) KR20190120331A (https=)
CN (1) CN111163771B (https=)
AU (1) AU2018226771B2 (https=)
BR (1) BR112019017741A2 (https=)
CA (1) CA3054809A1 (https=)
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WO (1) WO2018160774A1 (https=)

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US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
KR20240115232A (ko) 2021-10-19 2024-07-25 아이오엠엑스 테라퓨틱스 아게 Sik3 억제제 및 이의 중간체를 제조하기 위한 합성 반응식 및 과정
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JP2020509022A (ja) 2020-03-26
CA3054809A1 (en) 2018-09-07
KR20190120331A (ko) 2019-10-23
EP3589284A1 (en) 2020-01-08
RU2019129727A3 (https=) 2021-07-02
JP7296318B2 (ja) 2023-06-22
US11285158B2 (en) 2022-03-29
CN111163771A (zh) 2020-05-15
US20220133736A1 (en) 2022-05-05
RU2019129727A (ru) 2021-03-30
JP2023088968A (ja) 2023-06-27
AU2018226771A1 (en) 2019-09-19
US20240245695A1 (en) 2024-07-25
AU2018226771B2 (en) 2023-11-23
WO2018160774A1 (en) 2018-09-07
US11878019B2 (en) 2024-01-23
US20200253981A1 (en) 2020-08-13
BR112019017741A2 (pt) 2020-04-07
EP3589284A4 (en) 2020-12-16

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