CN111110613A - Degradable disinfectant wet tissue and preparation method thereof - Google Patents
Degradable disinfectant wet tissue and preparation method thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/41—Amines
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- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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Abstract
The invention belongs to the technical field of wet tissue processing and preparation, and particularly relates to a degradable disinfectant wet tissue and a preparation method thereof, wherein the method comprises the following preparation steps: s1: weighing a ground sample of the hypericum japonicum, decocting the ground sample with 7-8 times of water for 3 hours, filtering, concentrating under reduced pressure until the relative density is 1.15-1.2 at room temperature, and extracting with ethyl acetate to obtain a hypericum japonicum extract; s2: adding deionized water, surfactant, disodium edetate, synergist, and Aloe extract into a vertical mixing tank, stirring to dissolve completely, and mixing benzalkonium chloride with alkyl side chains of C12, C14, and C18; the invention mainly aims to provide the disinfectant wet tissue which can effectively clean and sterilize, does not stimulate the skin due to the excessive use of benzalkonium chloride, can prevent the collagen fiber, the elastic fiber and the like of the skin from losing elasticity and breaking to generate wrinkles when being used for makeup removal of women, and has good improvement effects on the generation of melanin, the generation of color spots and the like, and the preparation method thereof.
Description
Technical Field
The invention belongs to the technical field of daily chemical preparation, and particularly relates to a degradable disinfectant wet tissue and a preparation method thereof.
Background
Wet wipes are moist wipes for wiping the skin, and the wet wipes on the market can be roughly classified into two types: the wet tissue with the cleaning function can not meet the requirements along with the improvement of the sanitation and cleaning consciousness of people, and meanwhile, the wet tissue with the cleaning function is gradually favored.
Benzalkonium chloride is a cationic surfactant belonging to quaternary ammonium group, is a white waxy solid or yellow colloid, has neutral or weakly alkaline reaction in aqueous solution, generates a large amount of foams when shaken, is mainly used for industrial and medical disinfection, is very suitable for the cleaning field because of having certain oil removal and deodorization capabilities, is gradually applied to the field of disinfection wet tissues, has the concentration of 0.1-0.2 percent, can change the permeability of bacterial cytoplasmic membranes, enables the bacterial cytoplasmic substances to permeate and blocks the metabolism to play a role in killing, and for the detailed introduction of benzalkonium chloride, reference can be made to the research on the quality difference of domestic and foreign benzalkonium chloride, which is written by Chinese pharmacist
Referring to CN108192748A a cleaning wet tissue and a preparation method thereof, and CN101745137A a degradable disinfecting wet tissue and a preparation method and application thereof, in the prior art, currently, the concentration of benzalkonium chloride disinfectant used in the market is generally below 0.1%, but the antibacterial effect at this concentration does not meet the ideal requirement, and the concentration of benzalkonium chloride disinfectant to meet the requirement of disinfection and antibacterial should be 0.23-1%, however, when the concentration of benzalkonium chloride disinfectant exceeds 0.13%, the benzalkonium chloride will produce strong irritation to the skin along with the increase of the concentration of the disinfectant, and at the same time, the benzalkonium chloride is weakly alkaline, and when used in large amount, the benzalkonium chloride will have large irritation to the skin of a human body, and the buffering agent has no disinfecting effect, and when used in large amount, the disinfecting effect of the wet tissue will be reduced, and meanwhile, sweat stains and other impurities will be contained.
Disclosure of Invention
In order to make up the defects of the prior art, the invention provides a degradable disinfectant wet tissue and a preparation method thereof. The invention mainly aims to provide the disinfectant wet tissue which can effectively clean and sterilize, does not stimulate the skin due to the excessive use of benzalkonium chloride, can prevent the collagen fiber, the elastic fiber and the like of the skin from losing elasticity and breaking to generate wrinkles when being used for makeup removal of women, and has good improvement effects on the generation of melanin, the generation of color spots and the like, and the preparation method thereof.
The technical scheme adopted by the invention for solving the technical problems is as follows: the invention relates to a degradable disinfectant wet tissue, which takes the degradable disinfectant wet tissue as a carrier, and the effective components in the degradable disinfectant wet tissue comprise:
benzalkonium chloride 0.05-0.1%, hypericum japonicum extract 2.0-3.0%, surfactant 5%, disodium edetate 0.1%, synergist 0.05%, aloe extract 0.5%, citric acid 0.05-0.1%, pH buffer 30% and the balance of deionized water; the benzalkonium chloride is added into the carrier as a basic disinfection raw material, and the synergist is matched to effectively achieve a better disinfection effect, and the extracts added with the filipendula officinalis have higher improvement effect on skin color spots and can resist fungi and bacteria.
Preferably, the PH buffer comprises a chlorine dioxide solution, an organic or inorganic acid, and a PH buffering system; the carrier also contains one or more of other components of antiperspirant, deodorant, antiinflammatory, antipruritic or detergent, and a sub-liquid bag composed of water-soluble chitosan, iodophor and deionized water is arranged inside the packaging bag used for the disinfectant wet tissue; the PH buffer is prepared by mixing a chlorine dioxide solution, an organic acid or an inorganic acid and a pH buffer system, on one hand, alkalescence of benzalkonium chloride can be neutralized, on the other hand, chlorine dioxide and other acidic solutions can play an effective disinfection role, so that the problem of disinfection function reduction caused by addition of more buffers is solved during neutralization, one or more of an antiperspirant, a deodorant, an anti-inflammatory agent, an antipruritic agent or a detergent is/are added into a carrier and can be added according to needs, so that different use environments or different crowds are used, and the interference of human sweat or more dirt on disinfection can be effectively avoided.
Preferably, the synergist is any one or a mixture of two or more of phenoxyethanol, iodopropynyl butyl carbamate, 2-octyl-4-isothiazole azole-3-one, copper pyrithione, zinc pyrithione, magnesium pyrithione, sodium pyrithione, urea pyrithione, polyquaternary ammonium salt, quaternary ammonium salt 1227, quaternary ammonium salt 1427, quaternary ammonium salt 1827, biquaternary ammonium salt, ethylhexyl glycerin, 1, 2-octanediol, 1, 2-pentanediol, 1, 2-hexanediol and 1, 2-tetradecanediol; the cleaning antibacterial liquid is packaged through a carrier; the carrier is spunlace non-woven fabric; because the wet tissue is extremely easy to be polluted and damaged by microorganisms in the processes of manufacturing, transporting and storing, the disinfection effect is reduced, the antibacterial property of the wet tissue is further improved by adding the synergist, and the disinfection effect of the wet tissue can be effectively improved.
A method for preparing a degradable disinfectant wet wipe, which is suitable for any one of the degradable disinfectant wet wipes, comprises the following steps:
s1: weighing a ground sample of the hypericum japonicum, decocting the ground sample with 7-8 times of water for 3 hours, filtering, concentrating under reduced pressure until the relative density is 1.15-1.2 at room temperature, and extracting with ethyl acetate to obtain a hypericum japonicum extract; effective substances such as flavonoids, phenolic acids and steroids in the filigree pendula can be sufficiently separated out by sufficiently decocting the filigree pendula, and meanwhile, the effective substance components can be effectively diluted by adding a large amount of water, so that the effective substance components are conveniently and sufficiently extracted through ethyl acetate, the insufficient high-concentration extraction is avoided, and the raw material cost is increased.
S2: adding deionized water, a surfactant, disodium edetate, a synergist, an aloe extract and benzalkonium chloride into a reaction kettle, stirring until the mixture is completely dissolved to obtain a benzalkonium chloride mixture, heating the benzalkonium chloride mixture at 50 ℃ while stirring, preserving the heat for 30 minutes, then adding the filipendula sikkimensis extract prepared in S1 and citric acid into the reaction kettle, and stirring until the mixture is completely dissolved; through using reation kettle, can effectually carry out the intensive mixing to each raw materials, the hot plate heating in the cooperation reation kettle simultaneously can guarantee under different conditions, the uniformity of mixed ambient temperature avoids raw materials to condense under the lower temperature condition, stirs insufficient scheduling problem, through adding citric acid, vitamin C and fruit acid that contain in the lemon have antibiotic, soften and clean skin's effect to can deep clean and increase face elasticity, consequently the lemon facial mask has fine cosmetic efficiency.
S3: fully cooling, adding a pH buffering agent, adjusting the pH to 5-5.5 to obtain a cleaning antibacterial base solution, and finally adding one or more of an antiperspirant, a deodorant, an anti-inflammatory agent, an antipruritic agent or a detergent into the cleaning antibacterial base solution to obtain a cleaning antibacterial solution; by adding the pH buffering agent and the required functional agent, the use of the wet tissue under different crowds and different conditions can be avoided, and the application range of the wet tissue is widened.
S4: dipping the cut and sterilized non-woven fabric in the clean antibacterial base solution obtained in S3, sealing and packaging aseptically, and arranging a sub-solution bag in the packaging bag for arranging the disinfectant wet tissue in the packaging process to obtain the degradable disinfectant wet tissue; through setting up sub-liquid bag, because the functional agent of difference can dilute clean antibiotic base liquid, and then influences the disinfection merit efficiency of this wet piece of cloth, consequently through the sub-liquid bag that the inside setting that will disinfect the wet piece of cloth contains the functional agent, when needs use, can be earlier to carrying out cleaning and disinfecting through sub-liquid bag, get rid of a large amount of stains on skin surface, and then when using this wet piece of cloth of disinfecting, the effect is more.
Preferably, the carrier comprises a body, an isolation layer and adsorption fluff; the inside of the body is uniformly provided with locking layers at intervals; the sealing layer is filled with a clean antibacterial base liquid, the lower surface of the sealing layer is uniformly and fixedly provided with adsorption fluff, and the right end of the sealing layer at the lowest end is hermetically arranged in the right end wall of the body in a clamping and embedding manner; when in use, when the disinfection wet tissue is needed, one disinfection wet tissue can be taken out, then the sealing layer at the lowest end is taken off and is pasted on the skin to be repeatedly wiped along the same direction, because the lower surface of the sealing layer is uniformly and fixedly provided with the adsorption fluff, the sealing layer is internally filled with the cleaning antibacterial base liquid, so that the cleaning antibacterial base liquid in the adsorption fluff can be smeared on the hand when the adsorption fluff is contacted with the skin, thereby realizing the purpose of cleaning, and the adsorption fluff is in a moist state when being contacted with the skin, the friction force between the sealing layer and the skin is greatly increased, so that the sealing layer in the body is peeled off layer by layer, and simultaneously the cleaning antibacterial base liquid is smeared on the skin layer by layer, the compound effect of benzalkonium chloride in the cleaning antibacterial base solution is further promoted, so that the disinfection effect of the disinfection wet tissue is greatly improved.
Preferably, the right end of the locking layer is fixedly connected into the inner wall of the right end of the body in a point connection mode, and the right end of the locking layer is connected with a pressure strip in a sealing mode; the pressure strip is fixedly arranged in the inner wall of the right end of the body, and an opening at the outer end of the pressure strip is arranged right opposite to the locking layer; the during operation, when blockading the layer and being taken off by the taking off of one deck, adopt point to connect formula fixed connection in the right-hand member inner wall of body because of the right-hand member of blockading the layer, the right-hand member sealing connection on blockading the layer has the pressure strip, pressure strip fixed mounting is in the right-hand member inner wall of body, the outer end opening of pressure strip is just to blockading the layer setting, so even the frictional force that gets blockading the layer and skin improves greatly when absorption fine hair receives the frictional force of skin, even get its right-hand member and body disconnected, the mouth of releasing appears promptly in pressure strip outer end opening this moment, thereby realize that the pressure release produces a motive force to the pressure strip, blockading the layer right-hand member and the body break away from has been improved by a wide margin promptly, thereby ensure that.
The invention has the following beneficial effects:
1. the hypericum used in the invention is a perennial herb of the genus primula of the family Gramineae, also called catnip, goldhair hedyotis herb, and the hypericum contains compounds such as flavonoid, phenolic acid and steroid, wherein the flavonoid and the glycoside compound all show certain activity in the aspects of resisting fungi, bacteria and nematode, etc., the polysaccharide in the hypericum has good cleaning capability on superoxide anion and hydroxyl free radical, and the hypericum has good improving effect on the phenomena that the elasticity and the rupture of skin collagen fiber and elastic fiber, etc. cause the loss of elasticity and the rupture to generate wrinkle, generate melanin, generate color spots, etc. under the pathology or ultraviolet irradiation.
2. According to the technical scheme provided by the invention, benzalkonium chloride with broad spectrum and high efficiency is used as an antibacterial agent, and benzalkonium chloride with alkyl side chains of C12, C14 and C18 is reasonably compounded, so that the mutual synergistic effect among different quaternary ammonium salt molecules is maximized, the adsorption to bacteria is enhanced, the cracking speed of bacteria is further accelerated, and the obtained compound benzalkonium chloride with better antibacterial effect is obtained.
3. By adopting the technical scheme provided by the invention, when the disinfection wet tissue is required to be used, one disinfection wet tissue can be taken out, then the sealing layer at the lowest end is taken off and is pasted on the skin to be repeatedly wiped along the same direction, because the lower surface of the sealing layer is uniformly and fixedly provided with adsorption fluff, the sealing layer is filled with clean antibacterial liquid, so that the cleaning antibacterial liquid in the adsorption fluff can be smeared on the hand when the adsorption fluff is contacted with the skin, thereby realizing the purpose of cleaning, and the adsorption fluff is in a moist state when being contacted with the skin, the friction force between the sealing layer and the skin is greatly increased, so that the sealing layer in the body is peeled off layer by layer, and simultaneously the cleaning antibacterial liquid is smeared on the skin layer by layer, the compound effect of benzalkonium chloride in the cleaning antibacterial liquid is further promoted, so that the disinfection effect of the disinfection wet tissue is greatly improved.
Drawings
FIG. 1 is a front view of the present invention;
FIG. 2 is a schematic structural view of a vector of the present invention;
FIG. 3 is an enlarged view of a portion of the invention at A in FIG. 2;
in the figure: the body 1, the isolation layer 2 adsorbs fine hair 3, and blockade layer 4, pressure strip 5.
Detailed Description
A degradable disinfectant wipe and a method for preparing the same according to an embodiment of the present invention will be described below with reference to fig. 1 to 3.
As shown in fig. 1-3, the degradable disinfectant wet tissue of the present invention uses the degradable disinfectant wet tissue as a carrier, and the effective components inside the degradable disinfectant wet tissue comprise:
benzalkonium chloride 0.05-0.1%, hypericum japonicum extract 2.0-3.0%, surfactant 5%, disodium edetate 0.1%, synergist 0.05%, aloe extract 0.5%, citric acid 0.05-0.1%, pH buffer 30% and the balance of deionized water; the benzalkonium chloride is added into the carrier as a basic disinfection raw material, and the synergist is matched to effectively achieve a better disinfection effect, and the extracts added with the filipendula officinalis have higher improvement effect on skin color spots and can resist fungi and bacteria.
As an embodiment of the present invention, the PH buffer includes a chlorine dioxide solution, an organic or inorganic acid, and a PH buffering system; the carrier also contains one or more of other components of antiperspirant, deodorant, antiinflammatory, antipruritic or detergent, and a sub-liquid bag composed of water-soluble chitosan, iodophor and deionized water is arranged inside the packaging bag used for the disinfectant wet tissue; the PH buffer is prepared by mixing a chlorine dioxide solution, an organic acid or an inorganic acid and a pH buffer system, on one hand, alkalescence of benzalkonium chloride can be neutralized, on the other hand, chlorine dioxide and other acidic solutions can play an effective disinfection role, so that the problem of disinfection function reduction caused by addition of more buffers is solved during neutralization, one or more of an antiperspirant, a deodorant, an anti-inflammatory agent, an antipruritic agent or a detergent is/are added into a carrier and can be added according to needs, so that different use environments or different crowds are used, and the interference of human sweat or more dirt on disinfection can be effectively avoided.
As an embodiment of the present invention, the synergist is any one or a mixture of two or more of phenoxyethanol, iodopropynyl butyl carbamate, 2-octyl-4-isothiazole azole-3-one, copper pyrithione, zinc pyrithione, magnesium pyrithione, sodium pyrithione, urea pyrithione, polyquaternium, quaternary ammonium salt 1227, quaternary ammonium salt 1427, quaternary ammonium salt 1827, biquaternary ammonium salt, ethylhexylglycerin, 1, 2-octanediol, 1, 2-pentanediol, 1, 2-hexanediol, and 1, 2-tetradecanediol; the cleaning antibacterial liquid is packaged through a carrier; the carrier is spunlace non-woven fabric; because the wet tissue is extremely easy to be polluted and damaged by microorganisms in the processes of manufacturing, transporting and storing, the disinfection effect is reduced, the antibacterial property of the wet tissue is further improved by adding the synergist, and the disinfection effect of the wet tissue can be effectively improved.
A method for preparing a degradable disinfectant wet wipe, which is suitable for any one of the degradable disinfectant wet wipes, comprises the following steps:
s1: weighing a ground sample of the hypericum japonicum, decocting the ground sample with 7-8 times of water for 3 hours, filtering, concentrating under reduced pressure until the relative density is 1.15-1.2 at room temperature, and extracting with ethyl acetate to obtain a hypericum japonicum extract; effective substances such as flavonoids, phenolic acids and steroids in the filigree pendula can be sufficiently separated out by sufficiently decocting the filigree pendula, and meanwhile, the effective substance components can be effectively diluted by adding a large amount of water, so that the effective substance components are conveniently and sufficiently extracted through ethyl acetate, the insufficient high-concentration extraction is avoided, and the raw material cost is increased.
S2: adding deionized water, a surfactant, disodium edetate, a synergist, an aloe extract and benzalkonium chloride into a reaction kettle, stirring until the mixture is completely dissolved to obtain a benzalkonium chloride mixture, heating the benzalkonium chloride mixture at 50 ℃ while stirring, preserving the heat for 30 minutes, then adding the filipendula sikkimensis extract prepared in S1 and citric acid into the reaction kettle, and stirring until the mixture is completely dissolved; through using reation kettle, can effectually carry out the intensive mixing to each raw materials, the hot plate heating in the cooperation reation kettle simultaneously can guarantee under different conditions, the uniformity of mixed ambient temperature avoids raw materials to condense under the lower temperature condition, stirs insufficient scheduling problem, through adding citric acid, vitamin C and fruit acid that contain in the lemon have antibiotic, soften and clean skin's effect to can deep clean and increase face elasticity, consequently the lemon facial mask has fine cosmetic efficiency.
S3: fully cooling, adding a pH buffering agent, adjusting the pH to 5-5.5 to obtain a cleaning antibacterial base solution, and finally adding one or more of an antiperspirant, a deodorant, an anti-inflammatory agent, an antipruritic agent or a detergent into the cleaning antibacterial base solution to obtain a cleaning antibacterial solution; by adding the pH buffering agent and the required functional agent, the use of the wet tissue under different crowds and different conditions can be avoided, and the application range of the wet tissue is widened.
S4: dipping the cut and sterilized non-woven fabric in the clean antibacterial base solution obtained in S3, sealing and packaging aseptically, and arranging a sub-solution bag in the packaging bag for arranging the disinfectant wet tissue in the packaging process to obtain the degradable disinfectant wet tissue; through setting up sub-liquid bag, because the functional agent of difference can dilute clean antibiotic base liquid, and then influences the disinfection merit efficiency of this wet piece of cloth, consequently through the sub-liquid bag that the inside setting that will disinfect the wet piece of cloth contains the functional agent, when needs use, can be earlier to carrying out cleaning and disinfecting through sub-liquid bag, get rid of a large amount of stains on skin surface, and then when using this wet piece of cloth of disinfecting, the effect is more.
As an embodiment of the present invention, the carrier includes a body 1, a spacer 2 and adsorption fluff 3; the inside of the body 1 is uniformly provided with locking layers 4 at intervals; the sealing layer 4 is filled with clean antibacterial liquid, the lower surface of the sealing layer 4 is uniformly and fixedly provided with adsorption fluff 3, and the right end of the sealing layer 4 at the lowest end is hermetically arranged in the right end wall of the body 1 in a clamping and embedding manner; when the sterilizing wet tissue is needed to be used, one piece of the sterilizing wet tissue can be taken out, then the sealing and locking layer 4 at the lowest end is taken off and is attached to the skin to be repeatedly wiped along the same direction, because the lower surface of the sealing and locking layer 4 is uniformly and fixedly provided with the adsorption fluff 3, the interior of the sealing and locking layer 4 is filled with the cleaning antibacterial liquid, so that the cleaning antibacterial liquid inside the adsorption fluff 3 can be smeared on the hand when the adsorption fluff 3 contacts with the skin, thereby realizing the purpose of cleaning, and the adsorption fluff 3 is in a wet state when contacting with the skin, that is, the friction force between the blocking layer 4 and the skin is greatly increased, so that the blocking layer 4 in the body 1 is peeled layer by layer, and simultaneously the cleaning antibacterial liquid is smeared on the skin layer by layer, the compound effect of benzalkonium chloride in the cleaning antibacterial liquid is further promoted, so that the disinfection effect of the disinfection wet tissue is greatly improved.
As an embodiment of the invention, the right end of the sealing layer 4 is fixedly connected in the inner wall of the right end of the body 1 in a point connection manner, and the right end of the sealing layer 4 is connected with a pressure strip 5 in a sealing manner; the pressure strip 5 is fixedly arranged in the inner wall of the right end of the body 1, and an opening at the outer end of the pressure strip 5 is arranged opposite to the locking layer 4; the during operation, when blockading layer 4 is removed by the taking off of one deck, adopt point formula fixed connection in the right-hand member inner wall of body 1 because of blockading layer 4's right-hand member, blockading layer 4's right-hand member sealing connection has pressure strip 5, 5 fixed mounting of pressure strip are in the right-hand member inner wall of body 1, the outer end opening of pressure strip 5 is just to blockading layer 4 setting, so even get the frictional force of blockading layer 4 and skin to improve greatly when the frictional force that adsorbs fine hair 3 receives skin, even get its right-hand member and body 1 disconnected, the opening of revealing in 5 outer ends of pressure strip appears promptly this moment, thereby realize that the pressure release produces one propulsion to pressure strip 5, it breaks away from with body 1 to have improved blockading layer 4 right-hand members promptly, thereby ensure that blockading layer 4 can normally carry clean antibacterial liquid on the skin.
The specific working process is as follows:
when the disinfection wet tissue needs to be used, one disinfection wet tissue can be taken out, the sealing and locking layer 4 at the lowest end is taken off, the disinfection wet tissue is attached to the skin and repeatedly wiped along the same direction, the adsorption fluff 3 is uniformly and fixedly installed on the lower surface of the sealing and locking layer 4, and the cleaning antibacterial liquid is filled in the sealing and locking layer 4, so that the cleaning antibacterial liquid in the sealing and locking layer can be smeared on the hand when the adsorption fluff 3 is contacted with the skin, the cleaning aim is achieved, the adsorption fluff 3 is in a wet state when being contacted with the skin, namely, the friction force between the sealing and locking layer 4 and the skin is greatly increased, the sealing and locking layer 4 in the body 1 is stripped layer by layer, meanwhile, the cleaning antibacterial liquid is smeared on the skin layer by layer, the compounding effect of benzalkonium chloride in the cleaning antibacterial liquid is further promoted, and the disinfection effect of the disinfection wet tissue is greatly, when blockade layer 4 is removed by the taking off of one deck, adopt point formula fixed connection in the right-hand member inner wall of body 1 because of blockade layer 4's right-hand member, blockade layer 4's right-hand member sealing connection has pressure strip 5, pressure strip 5 fixed mounting is in body 1's right-hand member inner wall, pressure strip 5's outer end opening is just to blockade layer 4 setting, so even get the frictional force of blockade layer 4 and skin to improve greatly when adsorbing fine hair 3 and receiving the frictional force of skin, even get its right-hand member and body 1 disconnected, the propaganda escape orifice appears promptly in pressure strip 5 outer end opening this moment, thereby realize that the pressure release produces a motive force to pressure strip 5, it breaks away from with body 1 to have improved blockade layer 4 right-hand member promptly by a wide margin, thereby ensure that blockade layer 4 can normally carry clean antibiotic liquid toward skin.
The following illustrates specific embodiments of the present invention:
example 1
S1: weighing a ground sample of the hypericum japonicum, decocting the ground sample with 7-8 times of water for 3 hours, filtering, concentrating under reduced pressure until the relative density is 1.15-1.2 at room temperature, and extracting with ethyl acetate to obtain a hypericum japonicum extract;
s2: adding 92.72% of deionized water, 2% of fatty acid methyl ester ethoxylate, 3% of fatty alcohol-polyoxyethylene ether, 0.05% of disodium edetate, 0.05% of phenoxyethanol and 0.1% of aloe extract into a vertical mixing tank, stirring until the materials are completely dissolved, then fully mixing benzalkonium chloride with alkyl side chains of C12, C14 and C18 respectively to prepare a benzalkonium chloride mixture, wherein the weight ratio of C12, C14 and C18 benzalkonium chloride is 1:1:3, then adding 0.05% of the benzalkonium chloride mixture and 2% of hypericum japonicum extract into the vertical mixing tank, stirring until the materials are completely dissolved, then adding 0.03% of citric acid while stirring, and adjusting the pH to be 5-5.5 to prepare a clean antibacterial liquid;
s3: and (3) taking the cut and sterilized non-woven fabric, soaking the non-woven fabric with the clean antibacterial liquid obtained in the step (a), and sealing and aseptic packaging to obtain the degradable disinfectant wet tissue.
Example 2
S1: weighing a ground sample of the hypericum japonicum, decocting the ground sample with 7-8 times of water for 3 hours, filtering, concentrating under reduced pressure until the relative density is 1.15-1.2 at room temperature, and extracting with ethyl acetate to obtain a hypericum japonicum extract;
s2: adding 94.31% of deionized water, 5% of fatty alcohol-polyoxyethylene ether, 0.05% of disodium edetate, 0.06% of ethyl hexyl glycerol and 0.1% of aloe extract into a vertical mixing tank, stirring until the materials are completely dissolved, then fully mixing benzalkonium chlorides with alkyl side chains of C12, C14 and C18 respectively to prepare a benzalkonium chloride mixture, wherein the weight ratio of C12, C14 and C18 benzalkonium chlorides is 2:1:5, then adding 0.05% of the benzalkonium chloride mixture and 0.5% of the hypericum japonicum extract into the vertical mixing tank, stirring until the materials are completely dissolved, then adding 0.03% of citric acid while stirring, and adjusting the pH to be 5-5.5 to prepare a clean antibacterial liquid;
s3: and (3) taking the cut and sterilized non-woven fabric, soaking the non-woven fabric with the clean antibacterial liquid obtained in the step (a), and sealing and aseptic packaging to obtain the degradable disinfectant wet tissue.
Example 3
S1: weighing a ground sample of the hypericum japonicum, decocting the ground sample with 7-8 times of water for 3 hours, filtering, concentrating under reduced pressure until the relative density is 1.15-1.2 at room temperature, and extracting with ethyl acetate to obtain a hypericum japonicum extract;
s2: adding 92.69% of deionized water, 5% of alkyl polyglycoside, 0.05% of disodium edetate, 0.03% of 1, 2-octanediol and 0.1% of aloe extract into a vertical mixing tank, stirring until the materials are completely dissolved, then fully mixing benzalkonium chlorides with alkyl side chains of C12, C14 and C18 respectively to prepare a benzalkonium chloride mixture, wherein the weight ratio of the C12 to the C14 to the C18 benzalkonium chlorides is 1:2:5, then adding 0.06% of the benzalkonium chloride mixture and 2% of the hypericum japonicum extract into the vertical mixing tank, stirring until the materials are completely dissolved, then adding 0.07% of citric acid while stirring, and adjusting the pH to be 5-5.5 to prepare a clean antibacterial liquid;
s3: and (3) taking the cut and sterilized non-woven fabric, soaking the non-woven fabric with the clean antibacterial liquid obtained in the step (a), and sealing and aseptic packaging to obtain the degradable disinfectant wet tissue.
Control group 1
S1: weighing a ground sample of the hypericum japonicum, decocting the ground sample with 7-8 times of water for 3 hours, filtering, concentrating under reduced pressure until the relative density is 1.15-1.2 at room temperature, and extracting with ethyl acetate to obtain a hypericum japonicum extract;
s2: adding 91.72% of deionized water, 5% of fatty acid methyl ester ethoxylate, 0.05% of ethylene diamine tetraacetic acid, 0.03% of 1, 2-pentanediol and 0.1% of aloe extract into a vertical mixing tank, stirring until the materials are completely dissolved, then adding 3% of the filipendula sikkimensis extract into the vertical mixing tank, stirring until the materials are completely dissolved, then adding 0.10% of citric acid while stirring, and adjusting the pH value to be 5-5.5 to obtain a clean antibacterial solution;
s3: and (3) taking the cut and sterilized non-woven fabric, soaking the non-woven fabric with the clean antibacterial liquid obtained in the step (a), and sealing and aseptic packaging to obtain the degradable disinfectant wet tissue.
To verify the antibacterial effect of benzalkonium chloride and hypericum extract, the applicant also made the following experiments:
test strains
Escherichia coli (CMCC (b)44103), staphylococcus aureus (CMCC (b)26003), pseudomonas aeruginosa (CMCC10104), yeast: candida albicans (CMCC (F) 98001).
Preparation of the Medium
Different culture media are prepared according to different microbial strains. Nutrient agar medium: mixing and dissolving a certain amount of peptone, beef extract, sodium chloride and distilled water, adjusting the pH value to 7.2-7.4, adding agar, heating and dissolving in steam at 121 ℃ for sterilization for 20min, and culturing escherichia coli, staphylococcus aureus and pseudomonas aeruginosa. Sakheira agar medium: mixing a certain amount of glucose, peptone, agar and distilled water, heating to dissolve completely, adjusting pH to 5.6 + -0.2, and sterilizing with pressure steam at 115 deg.C for 30min for Candida albicans culture.
Preparation of bacterial suspension
A24-hour slant culture of a test bacterium is washed with 5mL of 0.03mol/L phosphate buffer solution (hereinafter referred to as PBS), and diluted with the PBS to a desired concentration to prepare a bacterial suspension (the desired concentration is that 100. mu.L of the bacterial suspension is dropped into 5mL of sample solution, and the number of recovered bacteria is 1 × 104 to 9 × 104 cfu/mL).
Antibacterial test
5 tubes of the test sample solution (5mL) and the control sample solution (the same material as the sample, the same size, but containing no antibacterial material and subjected to sterilization) were each collected. Taking the bacterial suspension, respectively dripping 100 mu L of the bacterial suspension into each tested sample liquid and each control sample liquid, uniformly mixing by using an electric mixer, timing, acting for 2, 5, 10 and 20min, respectively putting the sample liquid (0.5mL) into a test tube containing 5mL of corresponding neutralizing agent, fully and uniformly mixing, diluting properly, then taking 2-3 dilutions, respectively sucking 0.5mL, placing in two plates, pouring 15mL of nutrient agar medium (bacteria) or Shashi agar medium (yeast) cooled to 40-45 ℃, rotating the plates to fully and uniformly, turning the plates after agar solidification, culturing for 48h (bacteria) or 72h (yeast) at 35 +/-2 ℃, and counting viable bacterial colonies. The experiment was repeated 3 times and the average was taken.
Determination of antibacterial efficacy
After culturing for 48h or 72h, calculating the antibacterial rate according to the following formula: x ═ a-B)/a × 100%. In the formula: x is the antibacterial rate, A is the average colony number of the control sample, and B is the average colony number of the tested sample. Evaluation criteria: the antibacterial rate is more than or equal to 90 percent, and the product has antibacterial effect.
TABLE 1 antimicrobial efficacy graph
The antibacterial tests of the present examples 1-3 and the control group 1 were conducted by the above antibacterial test method, and finally, the antibacterial efficacy of the cleaning wet wipes of the present invention was judged to be much better than that of the control group based on the percentage of the concentration of the non-viable microorganisms to the initial concentration of the microorganisms.
While the present invention has been described with reference to the embodiments shown in the drawings, the present invention is not limited to the embodiments, which are illustrative and not restrictive, and it will be apparent to those skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (6)
1. A degradable disinfectant wet tissue is characterized in that: the degradable disinfectant wet tissue is used as a carrier, and the effective components in the degradable disinfectant wet tissue comprise:
0.05-0.1% of benzalkonium chloride, 2.0-3.0% of hypericum japonicum extract, 5% of surfactant, 0.1% of disodium edetate, 0.05% of synergist, 0.5% of aloe extract, 0.05-0.1% of citric acid, 30% of pH buffer and the balance of deionized water.
2. The degradable disinfectant wipe set forth in claim 1, wherein: the pH buffering agent comprises a chlorine dioxide solution, an organic acid or an inorganic acid and a pH buffering system; the carrier also contains one or more of antiperspirant, deodorant, antiinflammatory, antipruritic or detergent, and a sub-liquid bag composed of water soluble chitosan, iodophor and deionized water is arranged inside the packaging bag for the sterilized wet towel.
3. The degradable disinfectant wipe set forth in claim 1, wherein: the synergist is any one or a mixture of two or more of phenoxyethanol, iodopropynyl butyl carbamate, 2-octyl-4-isothiazole azole-3-one, copper pyrithione, zinc pyrithione, magnesium pyrithione, sodium pyrithione, urea pyrithione, polyquaternary ammonium salt, quaternary ammonium salt 1227, quaternary ammonium salt 1427, quaternary ammonium salt 1827, biquaternary ammonium salt, ethylhexyl glycerin, 1, 2-octanediol, 1, 2-pentanediol, 1, 2-hexanediol and 1, 2-tetradecanediol; the cleaning antibacterial liquid is packaged through a carrier; the carrier is spunlace nonwoven fabric.
4. A preparation method of degradable disinfectant wet tissue is characterized by comprising the following steps: the method is suitable for the degradable disinfectant wet tissue as described in any one of claims 1-3, and comprises the following preparation steps:
s1: weighing a ground sample of the hypericum japonicum, decocting the ground sample with 7-8 times of water for 3 hours, filtering, concentrating under reduced pressure until the relative density is 1.15-1.2 at room temperature, and extracting with ethyl acetate to obtain a hypericum japonicum extract;
s2: adding deionized water, a surfactant, disodium edetate, a synergist, an aloe extract and benzalkonium chloride into a reaction kettle, stirring until the mixture is completely dissolved to obtain a benzalkonium chloride mixture, heating the benzalkonium chloride mixture at 50 ℃ while stirring, preserving the heat for 30 minutes, then adding the filipendula sikkimensis extract prepared in S1 and citric acid into the reaction kettle, and stirring until the mixture is completely dissolved;
s3: fully cooling, adding a pH buffering agent, adjusting the pH to 5-5.5 to obtain a cleaning antibacterial base solution, and finally adding one or more of an antiperspirant, a deodorant, an anti-inflammatory agent, an antipruritic agent or a detergent into the cleaning antibacterial base solution to obtain a cleaning antibacterial solution;
s4: and (3) dipping the cut and sterilized non-woven fabric in the clean antibacterial base solution obtained in S3, sealing and packaging aseptically, and arranging a sub-solution bag in the packaging bag for arranging the disinfectant wet tissue in the packaging process to obtain the degradable disinfectant wet tissue.
5. The degradable disinfectant wet wipe as set forth in claim 4, wherein: the carrier comprises a body (1), an isolation layer (2) and adsorption fluff (3); the inside of the body (1) is uniformly provided with locking layers (4) at intervals; the inside packing of locking layer (4) has clean antibiotic base fluid, and the even fixed mounting of lower surface of locking layer (4) has absorption fine hair (3), and the right-hand member of lower extreme locking layer (4) passes through the form seal installation of inlay card in the right-hand member wall of body (1).
6. The degradable disinfectant wet wipe as set forth in claim 5, wherein: the right end of the locking layer (4) is fixedly connected into the inner wall of the right end of the body (1) in a point connection mode, and the right end of the locking layer (4) is connected with a pressure strip (5) in a sealing mode; the pressure strip (5) is fixedly installed in the inner wall of the right end of the body (1), and an opening in the outer end of the pressure strip (5) is arranged right opposite to the locking layer (4).
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116019879A (en) * | 2023-02-01 | 2023-04-28 | 廖传东 | Preparation method of Chinese herbal medicine for treating onychomycosis and Chinese herbal medicine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116019879A (en) * | 2023-02-01 | 2023-04-28 | 廖传东 | Preparation method of Chinese herbal medicine for treating onychomycosis and Chinese herbal medicine |
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