CN111066804A - Bactericidal composition containing chlorine indole hydrazide - Google Patents
Bactericidal composition containing chlorine indole hydrazide Download PDFInfo
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- CN111066804A CN111066804A CN201911270775.XA CN201911270775A CN111066804A CN 111066804 A CN111066804 A CN 111066804A CN 201911270775 A CN201911270775 A CN 201911270775A CN 111066804 A CN111066804 A CN 111066804A
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- hydrazide
- hymexazol
- chloroindole
- bactericidal composition
- composition containing
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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Abstract
The invention belongs to the field of pesticide compositions, and particularly relates to a bactericidal composition containing chloroindole hydrazide. The bactericidal composition comprises the effective components of chloroindoxyl and hymexazol in a weight ratio of 50: 1-1: 50, and can be further processed into a pesticide preparation which comprises an auxiliary agent and an active component, wherein the mass percentage of the chloroindoxyl and the hymexazol in the composition is 1-80%, and the balance is a pesticide auxiliary agent; the pesticide composition has special effects on controlling cucumber fungal downy mildew and cucumber fusarium wilt, and can also be used for controlling other plant diseases caused by fungal infection such as: chinese cabbage root rot, cotton damping-off, tomato gray mold, pepper fungal anthracnose, rice sheath blight, wheat scab, welsh onion purple spot, eggplant sclerotinia rot, watermelon gummy stem blight, tomato late blight, etc. The invention has the characteristics of high efficiency, low toxicity and low residue, and is particularly beneficial to the production of green food.
Description
Technical Field
The invention belongs to the field of pesticide synergistic compositions, and particularly relates to a bactericidal composition containing chloroindolohydrazide and hymexazol.
Background
The chloroindole hydrazide is a tetrahydro-carboline compound containing an acylhydrazone structure, and has good biological activity on fungal diseases of crops. Easy to be absorbed by plants, easy to be degraded in the environment and good in environmental compatibility.
Chemical name: (E) -N' - (4-chlorophenylmethylene) -1-methyl-2, 3,4, 9-tetrahydro-1H-pyrido [3,4-b ] indole-3-carboxylic acid hydrazide (formula I below, all referred to herein as chloroindole hydrazide).
The hymexazol is 3-hydroxy-5-methylisoxazole in chemical name, belongs to oxazole bactericides, has an action mechanism for inhibiting the mitochondrial respiration of pathogenic bacteria, but is different from β -methoxy acrylate bactericides, has a good control effect on plant diseases caused by various pathogenic fungi, has a good treatment effect on pythium, saprophytic rot, fusarium, rhizoctonia, pythium, rhizoctonia and snow mold of hyphomycotina, is a high-efficiency, low-toxicity and environment-friendly bactericide and soil disinfectant, is a plant growth regulator, has systemic property and conductivity, can be directly absorbed by the roots of plants, can rapidly move in the plants, can improve the pesticide effect in the soil, has long lasting period, still has bactericidal activity within two weeks, has a unique action mechanism, is high-efficiency, micro-toxicity and pollution-free, can effectively inhibit the normal growth of the pathogenic fungi or directly kill the soil fungi, fusarium, rhizoctonia solani, rhizoctonia solani, has a special effect on rhizoctonia rot, blight resistance, blight resistance, seedling blight resistance, seedling blight resistance, seedling resistance, and the like.
At present, some chlorine indole hydrazide patents have a lot of applications in the aspect of crop virus disease resistance. However, the treatment effect of the chloroindoxyl on plant fungal diseases is not reported at present. In addition, the single use of the pesticide brings resistance risk, and the pesticide compounding is an effective way for solving the resistance problem. The price of developing a new product of bactericide is high, the period is long, and compared with the price of developing and researching a high-efficiency, low-toxicity and low-residue compound and mixture, the investment is small, the development period is short, the attention at home and abroad is paid to the development, and the development strength is increased at a large margin. At present, the combination of hymexazol and chloroindoxyl hydrazide is not reported.
Disclosure of Invention
The invention provides a bactericidal composition containing chloroindole hydrazide, which has very remarkable prevention and treatment effects on fungal diseases of various crops such as vegetables, melons and fruits, and the like, such as cucumber fungal downy mildew, cucumber fusarium wilt, Chinese cabbage root rot, cotton damping-off, tomato gray mold, pepper fungal anthracnose, rice sheath blight, wheat scab, welsh onion purple spot, eggplant sclerotinia rot, watermelon gummy stem blight, tomato late blight and the like.
The effective components of the bactericidal composition containing the chloroindolohydrazide comprise 1-80% by mass of the chloroindolohydrazide and hymexazol, wherein the weight part ratio of the chloroindolohydrazide to the hymexazol is 50: 1-1: 50; preferably, the weight ratio of the chloroindole hydrazide to the hymexazol is 5: 1-1: 20.
The auxiliary components in the composition comprise acceptable emulsifying agents, surfactants and the like; agricultural milk 500#, agricultural milk 400#, agricultural milk 600# and the like are preferred.
The surfactants are:
anionic surfactants including fatty acid salts such as alkylbenzenesulfonates, lignosulfonates, alkylsulfates, and alkyl polyoxyethylene ether carboxylates, and also phosphate ester salts, sulfosuccinate ester salts, naphthalenesulfonates, and sulfonate formaldehyde condensates;
cationic surfactants including amine salts, quaternary ammonium salts, amine oxides, and the like; amphoteric surfactants include betaines, imidazolines, amino acids, phosphine esters, and the like;
nonionic surfactants including alkoxylates such as fatty alcohol ethers, alkylphenol ethers, alkylamine ethers, polyethers and the like; and fatty alcohol esters such as glycerol esters and polyhydric alcohol esters; and fatty acid alkyl esters, alkyl amides, and the like; the solvent includes heavy benzene, ethyl acetate, sec-butyl acetate, etc.
Other auxiliary components also comprise xanthan gum, thickening agents such as sodium carboxymethyl starch and the like, and antifreezing agents such as ethylene glycol, glycerol, urea and the like;
kaolin, bentonite, attapulgite, calcium carbonate and other fillers,
and other stabilizers, safeners, colorants, etc. acceptable for pesticide formulations.
The composition provided by the invention takes the chloroindoxyl and the hymexazol as main active ingredients, and the chloroindoxyl and the hymexazol and one or more of the auxiliary ingredients are prepared into different formulations according to a conventional pesticide method, so that the chloroindoxyl and the hymexazol can be selectively prepared according to needs, the application range is wide, and the market requirements are met. In the present invention, other adjuvants such as penetrants, emulsifiers, builders, etc., which are well known to those skilled in the art, may be included if desired.
The compound preparation of the chloroindoxyl hydrazide and the hymexazol is mainly used for preventing and treating crop mycosis by spraying or irrigating roots, spraying is carried out from the initial stage of disease occurrence, and the application is carried out 2-3 times after 7-10 days for the 2 nd time. The preparation is diluted by 500-3000 times and is uniformly sprayed or irrigated to roots.
The invention has the beneficial effects that:
1. the chloroindoxyl and the hymexazol have a synergistic effect on the prevention and the treatment of fungal diseases of various crops such as vegetables, melons and fruits, crops and the like within a certain proportion range.
2. The hymexazol and the chloroindoxyl hydrazide are compounded, so that the using amount of the pesticide is reduced, the use cost is reduced, the pollution to the environment is reduced, the generation of the drug resistance of plant diseases and insect pests is delayed, and the service life of the pesticide is prolonged.
Detailed Description
The present invention will be described in further detail with reference to examples. These examples should not be construed as limiting the invention. The additives used in the following control agents are all the additives used in the samples in the examples, are emulsifying dispersants commonly used in pesticide preparations, and no synergistic additive is added, so that the difference of pesticide effects excludes the difference caused by different additives.
Example 1: 12% chloroindolohydrazide hymexazol water agent
The raw materials by weight ratio: 10% of hymexazol, 2% of chloroindoxyl hydrazide, 18% of tween 60, 15% of monopotassium phosphate and 100% of water supplement. The preparation method comprises the following steps: the preparation method is carried out according to the conventional production mode of water aqua.
Example 1 comparative efficacy tests were performed comparing the control agents 5% chloroindoxyl hydrazide aqueous suspension (laboratory home made) and 15% hymexazol aqueous solution (purchased ex-situ). The control object is: root rot of Chinese cabbage and gray mold of tomato.
When the medicine is taken, the average temperature is 21-25 ℃, the weather is mainly clear, and the data show that: compared with a single preparation, the compound preparation has the following dosage ratio that two single preparations are 1: 1, the dosage is reduced by about 10 percent after mixing, but the control efficiency is about 15 percent higher than that of the control efficiency of two single agents after being superposed, and the control efficiency is obviously improved.
Preparation example two: preparation of 16% chloroindoxyl hydrazide hymexazol emulsifiable concentrate
The raw materials by weight ratio: 8 percent of chloroindoxyl hydrazide, 8 percent of hymexazol, 6 percent of Nongru 500#, 5 percent of Nongru 400#, 5 percent of Nongru 600#, and the balance being made up by using heavy benzol. The preparation method comprises the following steps: the emulsion is prepared by a conventional emulsion production mode.
Example 2 comparative efficacy tests were performed comparing the control agents 5% chloroindolhydrazide aqueous suspension (laboratory home made) and 15% hymexazol aqueous solution (purchased from outsourcing). The control object is: downy mildew of cucumber
When the medicine is taken, the average temperature is 21-25 ℃, the weather is mainly clear, and the data show that: compared with a single preparation, the compound preparation has the following dosage ratio that two single preparations are 1: 1, the dosage of the mixture is reduced by about 10 percent, but the control efficiency is about 20 percent higher than that of the mixture obtained by superposing two single agents, and the control efficiency is obviously improved.
Preparation example three: preparation of 30% chloroindolohydrazide and hymexazol large granule
The raw materials by weight ratio: 25% of chloroindoxyl hydrazide, 5% of hymexazol, 5% of sodium carboxymethyl starch, 45% of water washed sand, 3% of rose essence, and the balance of kaolin. Is prepared according to the conventional production mode of spreading granules.
Example 3 comparative test of efficacy of control drug 2% chloroindoxyl hydrazide large granules (laboratory made) and 30% hymexazol large granules (laboratory made) for comparison.
The control object is: rice sheath blight disease.
When the medicine is taken, the average temperature is 21-25 ℃, the weather is mainly clear, and the data show that: compared with a single preparation, the compound preparation has the following dosage ratio that two single preparations are 1: 1, the dosage is reduced by more than 10 percent after mixing, but the control efficiency is improved compared with the control efficiency after two single agents are superposed.
Formulation example four: preparation of 33% chloroindoxyl hydrazide and hymexazol water dispersible granules
The raw materials by weight ratio: chloroindoxyl 3%, hymexazol 30%, sodium methylene dinaphthalene sulfonate 12%, naphthalene sulfonate formaldehyde condensate 6%, polycarboxylate 15%, the balance being made up by oxidized corn starch. Is prepared according to the conventional granule production mode.
Example 4 comparative efficacy tests were performed comparing the control agents 10% chloroindolhydrazide aqueous suspension (made in the laboratory) and 15% hymexazol aqueous solution (purchased ex-situ).
The control object is: cucumber fusarium wilt and tomato late blight.
When the medicine is taken, the average temperature is 21-25 ℃, the weather is mainly clear, and the data show that: compared with a single preparation, the compound preparation has the following dosage ratio that two single preparations are 1: 1, the dosage is reduced by more than 10 percent after mixing, but the control efficiency is improved to more than 90 percent compared with the control efficiency after two single agents are superposed. The control efficiency is obviously improved.
Formulation example five: preparation of 42% chloroindoxyl hydrazide hymexazol wettable powder
The raw materials by weight ratio: 2% of chloroindole hydrazide, 40% of hymexazol, 6% of calcium dodecyl benzene sulfonate, 20% of calcium lignosulfonate, 5% of naphthalene sulfonate formaldehyde condensate dispersant, 3% of polycarboxylate dispersant and the balance of white carbon black. Is prepared according to the conventional wettable powder production mode.
Example 5 a comparative test of efficacy was carried out comparing the control agents 20% chloroindolhydrazide, WP (made in the laboratory) and 15% hymexazol water (purchased ex-situ).
The control object is: purple spot of green Chinese onion and gummy stem blight of watermelon.
When the medicine is taken, the average temperature is 21-25 ℃, the weather is mainly clear, and the data show that: compared with a single preparation, the compound preparation has the following dosage ratio that two single preparations are 1: 1, the dosage of the mixture is reduced by about 20 percent, but the control efficiency is improved by more than 20 percent compared with the control efficiency of the mixture obtained by superposing two single agents, and the control efficiency is obviously improved.
Formulation example six: preparation of 15.3% chloroindoxyl hydrazide hymexazol emulsifiable concentrate
The raw materials by weight ratio: 15% of chloroindole hydrazide, 0.3% of hymexazol, 10% of Nongru 500#, 7% of Nongru 400#, 6% of Nongru 600#, and the rest is complemented with heavy benzol. Prepared according to a conventional missible oil production mode.
Example 6 comparative efficacy tests were performed comparing the control agents 5% chloroindolhydrazide aqueous suspension (laboratory home made) and 15% hymexazol aqueous solution (purchased from outsourcing).
The control object is: damping-off of cotton, rice sheath blight.
When the medicine is taken, the average temperature is 21-25 ℃, the weather is mainly clear, and the data show that: compared with a single preparation, the compound preparation has the following dosage ratio that two single preparations are 1: 1, the dosage is reduced by more than 10 percent after mixing, but the control efficiency is improved compared with the control efficiency after two single agents are superposed.
Formulation example seven: preparation of 76.5% chloroindolohydrazide hymexazol wettable powder
The raw materials by weight ratio: 1.5 percent of chloroindole hydrazide, 75 percent of hymexazol, 5 percent of calcium dodecyl benzene sulfonate, 4 percent of calcium lignosulfonate, 3 percent of naphthalene sulfonate formaldehyde condensate dispersant, 2 percent of polycarboxylate dispersant and white carbon black. Is prepared according to the conventional wettable powder production mode.
Example 7 the control agents 20% chloroindolhydrazide WP (made by the laboratory) and 15% hymexazol water (purchased externally) were compared for efficacy comparison tests.
The control object is: wheat scab.
When the medicine is taken, the average temperature is 21-25 ℃, the weather is mainly clear, and the data show that: compared with a single preparation, the compound preparation has the following dosage ratio that two single preparations are 1: 1, the dosage is reduced by more than 10 percent after mixing, but the control efficiency is improved compared with the control efficiency after two single agents are superposed.
From the above examples, it can be seen that the control effect of the single chloroindole hydrazide or hymexazol agent on most plant fungal diseases is below about 80%, the control effect can reach above 85% after the chloroindole hydrazide or hymexazol is compounded with the single chloroindole fungal diseases, and the highest control effect reaches about 96%; compared with a single preparation, the dosage of the compound preparation is 1: 1 the dosage of the effective components is reduced by more than 10 percent after the two single agents are mixed, but the control efficiency is improved to 10 to 20 percent compared with the control efficiency after the two single agents are superposed. Has obvious synergistic effect.
Claims (5)
1. The bactericidal composition containing the chloroindolohydrazide is characterized in that the effective components comprise the chloroindolohydrazide and hymexazol.
2. The bactericidal composition containing chloroindole hydrazide according to claim 1, wherein the weight ratio of the chloroindole hydrazide to the hymexazol is 50: 1-1: 50.
3. The bactericidal composition containing chloroindole hydrazide according to claim 2, wherein the weight ratio of the chloroindole hydrazide to the hymexazol is 5: 1-1: 20.
4. The bactericidal composition containing chloroindole hydrazide according to any one of claims 1 to 3, wherein the effective components of chloroindole hydrazide and hymexazol are 1 to 80 percent by mass of the composition.
5. The bactericidal composition containing the chloroindole hydrazide as claimed in claim 1, which is used for preventing and treating fungal diseases of crops, including cucumber fungal downy mildew, cucumber fusarium wilt, Chinese cabbage root rot, cotton damping-off, tomato gray mold, pepper fungal anthracnose, rice sheath blight, wheat scab, welsh onion purple spot, eggplant sclerotinia rot, watermelon gummy stem blight and tomato late blight.
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Application publication date: 20200428 |