CN111065619A - (E)-α,β-不饱和酰胺化合物及其制备方法和用途 - Google Patents

(E)-α,β-不饱和酰胺化合物及其制备方法和用途 Download PDF

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CN111065619A
CN111065619A CN201880052484.0A CN201880052484A CN111065619A CN 111065619 A CN111065619 A CN 111065619A CN 201880052484 A CN201880052484 A CN 201880052484A CN 111065619 A CN111065619 A CN 111065619A
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methyl
methoxy
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enamide
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CN111065619B (zh
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赵旭阳
白骅
龚永祥
刘礼飞
钟金清
张鑫龙
冯仁田
姬凯歌
丁芳
刘伟伟
李译
陈文�
龚佑静
朱勇霖
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Zhejiang Hisun Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

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  • Chemical & Material Sciences (AREA)
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Abstract

本发明提供一类新的由式I所表示的(E)‑α,β‑不饱和酰胺化合物，还涉及这类化合物的制备方法及其制药用途。所述化合物具有保护神经细胞的作用和免疫调节活性。式I中R1、R2和R3的定义见说明书。

Description

PCT国内申请，说明书已公开。

Claims (30)

  1. PCT国内申请，权利要求书已公开。
CN201880052484.0A 2017-08-29 2018-08-29 (E)-α,β-不饱和酰胺化合物及其制备方法和用途 Active CN111065619B (zh)

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CN201710760142 2017-08-29
CN2017107601421 2017-08-29
PCT/CN2018/102824 WO2019042301A1 (zh) 2017-08-29 2018-08-29 (E)-α,β-不饱和酰胺化合物及其制备方法和用途

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111606828A (zh) * 2019-02-22 2020-09-01 浙江海正药业股份有限公司 (E)-α,β-不饱和酰胺化合物的晶型及其制备方法和用途
CN113149894A (zh) * 2020-06-22 2021-07-23 上海长车生物科技有限公司 (e)-3-芳杂环基丙-2-烯酸衍生物的制药用途

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023202A1 (en) * 1995-12-22 1997-07-03 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON Subtype-selective nmda receptor ligands and the use thereof
US6414013B1 (en) * 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
JP2005060247A (ja) * 2003-08-12 2005-03-10 Takeda Chem Ind Ltd イソキノリノン誘導体、その製造法および用途
CN103073440A (zh) * 2013-02-21 2013-05-01 四川大学 一类二苯乙烯氧烷基胺类化合物、其制备方法和用途
CN104169261A (zh) * 2012-02-07 2014-11-26 什诺波特有限公司 富马酸吗啉代烃基酯化合物、药物组合物和使用方法
CN105452213A (zh) * 2013-03-14 2016-03-30 阿尔克梅斯制药爱尔兰有限公司 富马酸酯前体药物及其在治疗多种疾病中的应用
CN107001391A (zh) * 2014-10-01 2017-08-01 默克专利股份公司 硼酸衍生物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023202A1 (en) * 1995-12-22 1997-07-03 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON Subtype-selective nmda receptor ligands and the use thereof
US6414013B1 (en) * 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
JP2005060247A (ja) * 2003-08-12 2005-03-10 Takeda Chem Ind Ltd イソキノリノン誘導体、その製造法および用途
CN104169261A (zh) * 2012-02-07 2014-11-26 什诺波特有限公司 富马酸吗啉代烃基酯化合物、药物组合物和使用方法
CN103073440A (zh) * 2013-02-21 2013-05-01 四川大学 一类二苯乙烯氧烷基胺类化合物、其制备方法和用途
CN105452213A (zh) * 2013-03-14 2016-03-30 阿尔克梅斯制药爱尔兰有限公司 富马酸酯前体药物及其在治疗多种疾病中的应用
CN107001391A (zh) * 2014-10-01 2017-08-01 默克专利股份公司 硼酸衍生物

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111606828A (zh) * 2019-02-22 2020-09-01 浙江海正药业股份有限公司 (E)-α,β-不饱和酰胺化合物的晶型及其制备方法和用途
CN111606828B (zh) * 2019-02-22 2023-07-28 浙江海正药业股份有限公司 (E)-α,β-不饱和酰胺化合物的晶型及其制备方法和用途
CN113149894A (zh) * 2020-06-22 2021-07-23 上海长车生物科技有限公司 (e)-3-芳杂环基丙-2-烯酸衍生物的制药用途

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