CN111050913B - 与硅基传感器集成的注射成型的微流体/流体盒 - Google Patents

与硅基传感器集成的注射成型的微流体/流体盒 Download PDF

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CN111050913B
CN111050913B CN201880056178.4A CN201880056178A CN111050913B CN 111050913 B CN111050913 B CN 111050913B CN 201880056178 A CN201880056178 A CN 201880056178A CN 111050913 B CN111050913 B CN 111050913B
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channel
input
output
sensor
plastic substrate
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CN111050913A (zh
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李晨
诚·弗兰克·钟
刘宇
欧阳伊雯
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MGI Tech Co Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
    • B01L2400/027—Drop detachment mechanisms of single droplets from nozzles or pins electrostatic forces between substrate and tip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201880056178.4A 2017-09-01 2018-08-31 与硅基传感器集成的注射成型的微流体/流体盒 Active CN111050913B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762553614P 2017-09-01 2017-09-01
US62/553,614 2017-09-01
PCT/US2018/049039 WO2019046690A1 (en) 2017-09-01 2018-08-31 INTEGRATED INJECTION MICROFLUIDIC / FLUID CARTRIDGE WITH SILICON-BASED SENSOR

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CN111050913A CN111050913A (zh) 2020-04-21
CN111050913B true CN111050913B (zh) 2022-04-12

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US (1) US11007523B2 (enExample)
EP (2) EP3676010B1 (enExample)
JP (2) JP7169345B2 (enExample)
KR (1) KR102387367B1 (enExample)
CN (1) CN111050913B (enExample)
AU (1) AU2018325527B2 (enExample)
CA (1) CA3072484C (enExample)
TW (1) TWI758537B (enExample)
WO (1) WO2019046690A1 (enExample)

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DE102019112254A1 (de) * 2019-05-10 2020-11-12 Leonhard Kurz Stiftung & Co. Kg Mikrofluidische Anordnung, Verfahren zu deren Herstellung und Messsystem umfassend die mikrofluidische Anordnung sowie Verwendung
EP3965930A1 (de) 2019-05-10 2022-03-16 LEONHARD KURZ Stiftung & Co. KG Mikrofluidische anordnung, verfahren zu deren herstellung und messsystem umfassend die mikrofluidische anordnung sowie verwendung
SG11202012495YA (en) * 2019-05-21 2021-01-28 Illumina Inc Sensors having an active surface
CN111013676A (zh) * 2019-12-17 2020-04-17 江苏圣极基因科技有限公司 一种液滴制备方法及微流控芯片
US11808569B2 (en) * 2020-03-22 2023-11-07 Strike Photonics, Inc. Waveguide enhanced analyte detection apparatus
FR3114092B1 (fr) * 2020-09-17 2022-08-26 Commissariat Energie Atomique Procédé de fabrication d'un dispositif micro-fluidique et dispositif fabriqué par ledit procédé
TW202231156A (zh) 2021-01-15 2022-08-01 美商伊路米納有限公司 實現感測器頂側打線接合
CA3223107A1 (en) * 2021-11-05 2023-05-11 Ravi Billa Sensor having an active surface
WO2024173811A1 (en) * 2023-02-17 2024-08-22 Twist Bioscience Corporation Vertical flow cell for biomolecule extraction
KR20240177093A (ko) 2023-06-19 2024-12-27 (주)페블아이 현장검사를 위한 휴대용 바이오칩
DE102023126573A1 (de) * 2023-09-28 2025-04-03 Bürkert Werke GmbH & Co. KG Einweg-Fluidführungsbaugruppe, Verfahren zur Herstellung der Einweg-Fluidführungsbaugruppe, mikrofluidische Vorrichtung mit Einweg-Fluidführungsbaugruppe sowie Proteindefektdiagnosevorrichtung
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EP3676010B1 (en) 2024-07-03
EP4382474A3 (en) 2024-09-25
US11007523B2 (en) 2021-05-18
EP3676010A1 (en) 2020-07-08
KR102387367B1 (ko) 2022-04-14
EP4382474A2 (en) 2024-06-12
CA3072484C (en) 2022-05-24
WO2019046690A1 (en) 2019-03-07
AU2018325527A1 (en) 2020-02-27
JP7169345B2 (ja) 2022-11-10
US20190070606A1 (en) 2019-03-07
CN111050913A (zh) 2020-04-21
EP3676010A4 (en) 2021-09-08
TWI758537B (zh) 2022-03-21
TW201928331A (zh) 2019-07-16
JP2023002784A (ja) 2023-01-10
JP2020532722A (ja) 2020-11-12
KR20200042534A (ko) 2020-04-23
CA3072484A1 (en) 2019-03-07
AU2018325527B2 (en) 2021-09-16

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