CN111035676A - 预防和缓解老年人眼病的有机硒滴眼液及其制备方法 - Google Patents
预防和缓解老年人眼病的有机硒滴眼液及其制备方法 Download PDFInfo
- Publication number
- CN111035676A CN111035676A CN202010032297.5A CN202010032297A CN111035676A CN 111035676 A CN111035676 A CN 111035676A CN 202010032297 A CN202010032297 A CN 202010032297A CN 111035676 A CN111035676 A CN 111035676A
- Authority
- CN
- China
- Prior art keywords
- organic selenium
- eye
- preventing
- relieving
- eye drops
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title claims abstract description 51
- 239000011669 selenium Substances 0.000 title claims abstract description 51
- 229910052711 selenium Inorganic materials 0.000 title claims abstract description 51
- 239000003889 eye drop Substances 0.000 title claims abstract description 36
- 208000030533 eye disease Diseases 0.000 title claims abstract description 32
- 229940012356 eye drops Drugs 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 17
- 244000035851 Chrysanthemum leucanthemum Species 0.000 claims abstract description 11
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 claims abstract description 11
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 10
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 10
- 235000003805 Musa ABB Group Nutrition 0.000 claims abstract description 10
- 240000008790 Musa x paradisiaca Species 0.000 claims abstract description 10
- 235000015266 Plantago major Nutrition 0.000 claims abstract description 10
- 240000003705 Senecio vulgaris Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000011609 Pinus massoniana Nutrition 0.000 claims abstract description 3
- 241000018650 Pinus massoniana Species 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 9
- 230000001954 sterilising effect Effects 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 6
- RJFAYQIBOAGBLC-BYPYZUCNSA-N Selenium-L-methionine Chemical group C[Se]CC[C@H](N)C(O)=O RJFAYQIBOAGBLC-BYPYZUCNSA-N 0.000 claims description 5
- RJFAYQIBOAGBLC-UHFFFAOYSA-N Selenomethionine Natural products C[Se]CCC(N)C(O)=O RJFAYQIBOAGBLC-UHFFFAOYSA-N 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 229960002718 selenomethionine Drugs 0.000 claims description 5
- 238000002791 soaking Methods 0.000 claims description 5
- 230000001502 supplementing effect Effects 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims description 2
- 235000011613 Pinus brutia Nutrition 0.000 claims description 2
- 241000018646 Pinus brutia Species 0.000 claims description 2
- 241001236247 Pinus bungeana Species 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 241000218631 Coniferophyta Species 0.000 claims 1
- 208000002177 Cataract Diseases 0.000 abstract description 19
- 230000004438 eyesight Effects 0.000 abstract description 11
- 239000003814 drug Substances 0.000 abstract description 10
- 208000003464 asthenopia Diseases 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 3
- 229940091258 selenium supplement Drugs 0.000 description 35
- 230000000694 effects Effects 0.000 description 15
- 210000000695 crystalline len Anatomy 0.000 description 11
- 201000010041 presbyopia Diseases 0.000 description 10
- 210000004185 liver Anatomy 0.000 description 6
- 208000010412 Glaucoma Diseases 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 5
- 208000034699 Vitreous floaters Diseases 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 241000628997 Flos Species 0.000 description 3
- 244000068988 Glycine max Species 0.000 description 3
- 235000010469 Glycine max Nutrition 0.000 description 3
- 244000017020 Ipomoea batatas Species 0.000 description 3
- 235000002678 Ipomoea batatas Nutrition 0.000 description 3
- 244000269722 Thea sinensis Species 0.000 description 3
- 206010047513 Vision blurred Diseases 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000006196 drop Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000004410 intraocular pressure Effects 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 240000006740 Cichorium endivia Species 0.000 description 2
- 206010010741 Conjunctivitis Diseases 0.000 description 2
- 241000190633 Cordyceps Species 0.000 description 2
- 241000255925 Diptera Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 235000005205 Pinus Nutrition 0.000 description 2
- 241000218602 Pinus <genus> Species 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 229940093797 bioflavonoids Drugs 0.000 description 2
- 235000003733 chicria Nutrition 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 230000002740 effect on eyes Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 235000009569 green tea Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- -1 isotonic regulator Substances 0.000 description 2
- 239000002398 materia medica Substances 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 210000001525 retina Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229960003080 taurine Drugs 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- RVKOHSCTEHZRRT-SECBINFHSA-N (2r)-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine Chemical compound C1C[C@@H](N)CC2=C1C=CC=C2OC RVKOHSCTEHZRRT-SECBINFHSA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 206010007749 Cataract diabetic Diseases 0.000 description 1
- 240000005250 Chrysanthemum indicum Species 0.000 description 1
- 235000018959 Chrysanthemum indicum Nutrition 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 235000019750 Crude protein Nutrition 0.000 description 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
- 206010013774 Dry eye Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010015958 Eye pain Diseases 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010024214 Lenticular opacities Diseases 0.000 description 1
- 208000001140 Night Blindness Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 241000241413 Propolis Species 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 206010064930 age-related macular degeneration Diseases 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 235000019784 crude fat Nutrition 0.000 description 1
- 230000004452 decreased vision Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000007025 diabetic cataract Diseases 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 230000004406 elevated intraocular pressure Effects 0.000 description 1
- 206010014801 endophthalmitis Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 201000001371 inclusion conjunctivitis Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 206010023332 keratitis Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000001656 lutein Substances 0.000 description 1
- 229960005375 lutein Drugs 0.000 description 1
- 235000012680 lutein Nutrition 0.000 description 1
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 230000000626 neurodegenerative effect Effects 0.000 description 1
- 235000021062 nutrient metabolism Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 229940069949 propolis Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 201000008525 senile cataract Diseases 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 206010044325 trachoma Diseases 0.000 description 1
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 210000004127 vitreous body Anatomy 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及医药技术领域，具体涉及一种预防和缓解老年人眼病的有机硒滴眼液及其制备方法。所述的预防和缓解老年人眼病的有机硒滴眼液，辅料为纯水，每500mL辅料中，原料组成为千里光0.04‑0.06g、决明子0.01‑0.02g、车前草0.01‑0.02g、野菊花0.02‑0.04g、针松叶0.01‑0.02g、有机硒0.05‑0.1g。本发明的目的预防和缓解老年人眼病的有机硒滴眼液，成分简单，对眼睛无刺激，能够有效抑制白内障的生长，并且缓解眼部疲劳，提高视力；本发明还提供其制备方法。
Description
技术领域
本发明涉及医药技术领域，具体涉及一种预防和缓解老年人眼病的有机硒滴眼液及其制备方法。
背景技术
目前，中国的老年人数量越来越多，随着人年龄的增大，不可避免的会出现各种眼部问题。老年人视力变模糊、眼部不舒服等并不仅仅是人老了、眼花了这么简单，眼睛也事关老年人幸福生活的质量，所以患了眼疾应及早诊治。中老年人除了眼睛调节功能下降引起的“老花”问题，还有一些常见的眼病，如白内障、青光眼、飞蚊症、年龄相关性黄斑变性等。
老花眼是因人老后水晶体硬化或部分硬化，对光感调节不足，致使光线的焦点不能准确聚集在视网膜上，而落在视网膜后面，使看近距离的物品和文字会出现模糊不清的现象。一般人在40岁左右都会开始出现不同程度的老花。白内障多在更年期前后出现，是由于原来清澈透明的晶状体发生混浊，光线无法完全穿透而造成视觉模糊。青光眼特征是眼压升高，引起眼组织水肿，严重者可引起神经纤维变性萎缩而引起视野缺损及视力降低，甚者导致失明。飞蚊症状多为眼前常有黑点飘来飘去，有时清楚，有时模糊，飞蚊症大部分是玻璃体老化所致。
针对老年人容易产生的眼部病症，也有不同的治疗方法。例如通过佩戴老花镜对视力进行矫正，通过手术对白内障进行治疗，通过口服药物或者外用药物对各种眼病进行治疗等。但是现有的滴眼液成分主要以西药成分为主，对眼睛有一定的刺激作用，长期使用会产生一定的依赖性，且价格较贵。
专利CN201410418618.X中公开了一种治疗白内障的滴眼液及其制备方法，原料部分是吡诺克辛钠、阿司匹林、牛磺酸、硒、锌和谷胱甘肽，辅料部分是由稀释剂、保湿剂、等渗调节剂、防腐剂、抗氧剂组成。其对初发期白内障有很好的疗效，特别适用于初期老年性白内障、轻度糖尿病性白内障或并发性白内障患者，可提高人体的生理机能，能加速眼前节血运循环和营养代谢，改善晶状体囊的通透性，恢复其生理屏障效应，有效控制晶状体浑浊，促进浑浊吸收。但是其主要以西药成分为主，长期使用会产生一定的依赖性，且价格较贵。
专利CN201910697785.5中公开了一种富硒护眼液及其制备方法；各组份为：富硒绿茶，虫草花，蜂胶，玉米须，黄豆，苣荬菜，紫薯，牛磺酸、芦荟、水溶性叶黄素、维生素B1；其配伍中加入富硒绿茶、玉米须、黄豆、苣荬菜、紫薯，具有明目、解除眼睛疲劳、预防和改善近视的功效，能够促进对硒等营养元素的吸收，改善视力，快速缓解眼部疲劳，黄豆、虫草花和紫薯氨基酸含量丰富，能够促进牛磺酸部分与其他氨基酸集合，提高细胞的增殖、移行和分化；具有良好的抗菌消炎能力，能够长期使用，应用环境良好。但是其成分较多，浓度较大，对眼睛有一定的刺激作用。
发明内容
针对现有技术的不足，本发明的目的是提供一种预防和缓解老年人眼病的有机硒滴眼液，成分简单，对眼睛无刺激，能够有效抑制白内障的生长，并且缓解眼部疲劳，提高视力；本发明还提供其制备方法。
本发明所述的预防和缓解老年人眼病的有机硒滴眼液，原料组成为千里光、决明子、车前草、野菊花、针松叶、有机硒；辅料为纯水。
所述的治疗老年人眼病的有机硒滴眼液，每500mL辅料中，原料组成为千里光0.04-0.06g、决明子0.01-0.02g、车前草0.01-0.02g、野菊花0.02-0.04g、针松叶0.01-0.02g、有机硒0.05-0.1g。
优选地，所述的治疗老年人眼病的有机硒滴眼液，每500mL辅料中，原料组成为千里光0.04g、决明子0.01g、车前草0.01g、野菊花0.02g、针松叶0.01g、有机硒0.05g。
有机硒为硒蛋氨酸。
本发明所述的预防和缓解老年人眼病的有机硒滴眼液的制备方法，步骤如下：
(1)按重量比和体积比称取千里光、决明子、车前草、野菊花、针松叶和辅料，将原料加入辅料中浸泡1-2h，然后煮沸1-2h，过滤得提取液；
(2)在提取液中加入有机硒，并补充辅料至初始值，混合均匀，灭菌、冷却后，即得预防和缓解老年人眼病的有机硒滴眼液。
步骤(2)中灭菌温度为100-120℃，灭菌时间为0.5-1h。
本发明采用中药提取物和有机硒相配合，共同起到治疗老年人眼病的效果。其中各组分的作用如下：
千里光具有清热解毒，清肝明目的功效。《本草图经》记载千里光“与甘草煮作饮服，退热明目”，《本草纲目拾遗》记载千里光“明目，去星障”。其可以用于治疗各种眼部感染性疾病，做成眼药水滴剂可治疗结膜炎、角膜炎、沙眼及病毒性眼炎等。
决明子具有清除肝火，驱邪风湿，补肾、利尿、明目的功效，眼科在临床上可用于夜盲症，结眼部炎症，白内障和青光眼，视疲劳的患者。
车前草有清热利尿、凉血解毒、清肝明目、清肺化痰的功效。青光眼多是因为眼压过高引起，而车前草就对眼压有明显降低作用，在治疗青光眼时能够降低眼压，明显减轻头痛眼痛的症状。
野菊花性味苦、辛，微寒，入肺、肝经，具有清热解毒，养肝明目的功效。《本草纲目》中记载野菊花“性甘、味寒，具有散风热、平肝明目之功效”，《神农本草经》认为，野菊花茶能“主诸风头眩、肿痛、目欲脱、皮肤死肌、恶风湿痹，久服利气，轻身耐劳延年”。
现代技术对松针的测试发现：松针提取物富含糖类、粗蛋白、粗脂肪、多种氨基酸和多种微量矿元素、多种维生素、生物黄酮类物质、精油、叶绿素、不饱和脂肪酸、酶与辅酶等活性物质。其中微量矿元素、多种维生素、生物黄酮类物质对眼干、眼涩、眼疲劳、视力模糊、老花眼、轻中度白内障等眼病有显著疗效。
有机硒在眼睛虹膜及晶状体内含量最高，人体长期缺硒，能使晶体产生自由基，使含硒的谷肤甘肤过氧化物酶减少，晶状体受过氧化氢的损害，就引发白内障等疾病。补硒能清除眼晶状体内的自由基，使晶状体内保持透明状态。
本发明制备的有机硒滴眼液在使用时，每日滴1-2次，每次滴1-2滴，滴入眼睛后闭目1-2min并轻轻按摩眼周围。
该有机硒滴眼液吸收迅速，对眼睛无任何刺激作用，对多种眼病具有预防和缓解效果，尤其对于白内障有很好的控制作用，能改善晶状体囊的通透性，恢复其生理屏障效应，有效控制晶状体浑浊，促进浑浊吸收。
与现有技术相比，本发明有以下有益效果：
(1)本发明的有机硒滴眼液制作简单，根据中医辨证论治，因病施治相结合的整体靶向论治、整体调控的原则，对多种眼病的预防和缓解效果显著，且对眼睛无任何刺激作用，长期使用无药物依赖性，无任何毒副作用；
(2)本发明的有机硒滴眼液能够控制白内障不再生长，能改善晶状体囊的通透性，恢复其生理屏障效应，有效控制晶状体浑浊，促进浑浊吸收；并对老花眼非常有效，能够提高视力，长期使用可摘除老花镜；还能够清除眼底垃圾，预防其他眼部疾病。
具体实施方式
以下结合实施例对本发明做进一步说明，但本发明的保护范围不仅限于此，该领域专业人员对本发明技术方案所作的改变，均应属于本发明的保护范围内。
实施例1
按以下配方和方法制备有机硒滴眼液：
(1)将千里光0.04g、决明子0.01g、车前草0.01g、野菊花0.02g、针松叶0.01g加入500mL纯水中浸泡2h，然后煮沸2h，过滤得提取液；
(2)在提取液中加入硒蛋氨酸0.05g，并补充纯水至500mL，混合均匀，在120℃温度下灭菌0.5h，冷却后，即得预防和缓解老年人眼病的有机硒滴眼液。
实施例2
按以下配方和方法制备有机硒滴眼液：
(1)将千里光0.06g、决明子0.02g、车前草0.02g、野菊花0.04g、针松叶0.02g加入500mL纯水中浸泡2h，然后煮沸2h，过滤得提取液；
(2)在提取液中加入硒蛋氨酸0.1g，并补充纯水至500mL，混合均匀，在100℃温度下灭菌1h，冷却后，即得预防和缓解老年人眼病的有机硒滴眼液。
实施例3
按以下配方和方法制备有机硒滴眼液：
(1)将千里光0.05g、决明子0.015g、车前草0.015g、野菊花0.03g、针松叶0.015g加入500mL纯水中浸泡1h，然后煮沸1h，过滤得提取液；
(2)在提取液中加入硒蛋氨酸0.08g，并补充纯水至500mL，混合均匀，在110℃温度下灭菌1h，冷却后，即得预防和缓解老年人眼病的有机硒滴眼液。
在100例60周岁以上的老人中进行临床试验，100例均有不同程度的老花眼，其中有56例患有轻中度白内障，32例患有飞蚊症。按照每日滴1-2次，每次滴1-2滴的使用频率使用实施例1制备的有机硒滴眼液，在使用3个月、6个月后进行回访，回访结果如表1所示：
表1临床试验结果
| 症状 | 病例 | 3个月改善率 | 6个月改善率 |
| 老花眼 | 100 | 82％ | 100％ |
| 白内障 | 56 | 87.5％ | 96.4％ |
| 飞蚊症 | 32 | 81.3％ | 100％ |
从表1可以看出，本发明制备的有机硒滴眼液对老年人的多种眼病均有治疗作用，能够明显改善老年人的老花眼、白内障和飞蚊症。
Claims (6)
1.一种预防和缓解老年人眼病的有机硒滴眼液，其特征在于：原料组成为千里光、决明子、车前草、野菊花、针松叶、有机硒；辅料为纯水。
2.根据权利要求1所述的预防和缓解老年人眼病的有机硒滴眼液，其特征在于：每500mL辅料中，原料组成为千里光0.04-0.06g、决明子0.01-0.02g、车前草0.01-0.02g、野菊花0.02-0.04g、针松叶0.01-0.02g、有机硒0.05-0.1g。
3.根据权利要求1所述的预防和缓解老年人眼病的有机硒滴眼液，其特征在于：每500mL辅料中，原料组成为千里光0.04g、决明子0.01g、车前草0.01g、野菊花0.02g、针松叶0.01g、有机硒0.05g。
4.根据权利要求1所述的预防和缓解老年人眼病的有机硒滴眼液，其特征在于：有机硒为硒蛋氨酸。
5.一种权利要求1-4任一项所述的预防和缓解老年人眼病的有机硒滴眼液的制备方法，其特征在于：步骤如下：
(1)按重量比和体积比称取千里光、决明子、车前草、野菊花、针松叶和辅料，将原料加入辅料中浸泡1-2h，然后煮沸1-2h，过滤得提取液；
(2)在提取液中加入有机硒，并补充辅料至初始值，混合均匀，灭菌、冷却后，即得预防和缓解老年人眼病的有机硒滴眼液。
6.根据权利要求5所述的预防和缓解老年人眼病的有机硒滴眼液的制备方法，其特征在于：步骤(2)中灭菌温度为100-120℃，灭菌时间为0.5-1h。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010032297.5A CN111035676A (zh) | 2020-01-13 | 2020-01-13 | 预防和缓解老年人眼病的有机硒滴眼液及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010032297.5A CN111035676A (zh) | 2020-01-13 | 2020-01-13 | 预防和缓解老年人眼病的有机硒滴眼液及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111035676A true CN111035676A (zh) | 2020-04-21 |
Family
ID=70244629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010032297.5A Pending CN111035676A (zh) | 2020-01-13 | 2020-01-13 | 预防和缓解老年人眼病的有机硒滴眼液及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111035676A (zh) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435763A (zh) * | 2014-12-08 | 2015-03-25 | 安龙县东方五官灵制品厂 | 一种治疗眼病的药物 |
-
2020
- 2020-01-13 CN CN202010032297.5A patent/CN111035676A/zh active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435763A (zh) * | 2014-12-08 | 2015-03-25 | 安龙县东方五官灵制品厂 | 一种治疗眼病的药物 |
Non-Patent Citations (1)
| Title |
|---|
| 杨天华编: "《人体健康与微量元素》", 30 September 2018, 黄河水利出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105362501A (zh) | 一种防辐射保护视力的饮料及其制备方法 | |
| CN109430856A (zh) | 一种养护眼睛改善视疲劳的保健食品配方及其制备方法 | |
| CN106539083A (zh) | 一种用于预防和治疗糖尿病视网膜病变、缓解视力疲劳的组合物 | |
| CN111202243A (zh) | 强化明目营养软胶囊特殊膳食食品及其制备方法 | |
| CN108125996A (zh) | 一种用于视疲劳、干眼的眼用制剂 | |
| CN114869885A (zh) | 和厚朴酚眼用药物的制备及其在真菌性角膜炎治疗中的应用 | |
| CN105106318B (zh) | 一种治疗干眼症的中药组合物及其制备方法 | |
| CN105106286A (zh) | 一种护眼明目的保健品 | |
| CN109010790A (zh) | 一种用于改善眼部疲劳的组合物及其应用 | |
| CN102526171B (zh) | 预防及延缓老年性黄斑变性功能的眼保健品及制作方法 | |
| CN107156839A (zh) | 一种护眼保健食品及其制备方法 | |
| CN1259081C (zh) | 一种治疗眼科疾病的口服液 | |
| CN116617366A (zh) | 一种缓解眼部疲劳预防近视的凝胶及其制备方法 | |
| CN113413415B (zh) | 一种羊毛甾醇滴眼液及其制备方法 | |
| CN111035676A (zh) | 预防和缓解老年人眼病的有机硒滴眼液及其制备方法 | |
| CN106692670A (zh) | 一种缓解视力疲劳的眼贴 | |
| CN111110817A (zh) | 一种治疗眼疾的中药组合物、制备方法及其应用 | |
| CN105920280A (zh) | 一种治疗视网膜病变及弱视的复方制剂及其制备方法 | |
| CN106177276A (zh) | 缓解视疲劳的眼药水及其制备方法 | |
| CN113332366A (zh) | 医药组成物用于制备治疗干眼症的药物的用途 | |
| CN105983006A (zh) | 一种缓解视疲劳的组合物及制备方法 | |
| CN115350230B (zh) | 一种预防近视的组方及制剂 | |
| CN107137603A (zh) | 一种缓解视疲劳的中药组合物、制剂及其制备方法 | |
| CN102973743B (zh) | 明视胶囊 | |
| CN100340265C (zh) | 一种改善电脑综合症的口服剂 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200421 |