CN111032041A - 治疗类风湿关节炎的组合物和方法 - Google Patents

治疗类风湿关节炎的组合物和方法 Download PDF

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CN111032041A
CN111032041A CN201880045404.9A CN201880045404A CN111032041A CN 111032041 A CN111032041 A CN 111032041A CN 201880045404 A CN201880045404 A CN 201880045404A CN 111032041 A CN111032041 A CN 111032041A
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compound
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pimozide
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CN201880045404.9A
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Chinese (zh)
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傅新元
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Jianaisi Biomedical Co ltd
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Jianaisi Biomedical Co ltd
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Priority to CN202311267811.3A priority Critical patent/CN117085015A/zh
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12N2800/00—Nucleic acids vectors
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880045404.9A 2017-05-16 2018-05-04 治疗类风湿关节炎的组合物和方法 Pending CN111032041A (zh)

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CN202311267811.3A CN117085015A (zh) 2017-05-16 2018-05-04 治疗类风湿关节炎的组合物和方法

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US201762506698P 2017-05-16 2017-05-16
US62/506,698 2017-05-16
PCT/US2018/031217 WO2018213027A1 (en) 2017-05-16 2018-05-04 Compositions and methods for treating rheumatoid arthritis

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US (2) US11612595B2 (https=)
EP (1) EP3628006A4 (https=)
JP (1) JP7493939B2 (https=)
KR (1) KR102707515B1 (https=)
CN (2) CN111032041A (https=)
AU (1) AU2018270772B2 (https=)
CA (1) CA3063100A1 (https=)
TW (1) TWI850196B (https=)
WO (1) WO2018213027A1 (https=)

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JP7527662B2 (ja) * 2019-04-09 2024-08-05 ジェネラス バイオファーマ リミテッド ピモジドとメトトレキサートの医薬組成物、及びその使用
EP3960175A4 (en) * 2019-04-26 2023-01-11 Generos Biopharma Ltd. USE OF A COMPOUND IN THE MANUFACTURE OF A MEDICATION FOR THE TREATMENT OF ATHEROSCLEROSIS
CA3133733A1 (en) * 2019-04-30 2020-11-05 Xin-Yuan Fu Compounds for treating inflammation induced autoimmune skin diseases and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104854130A (zh) * 2012-11-01 2015-08-19 加利福尼亚大学董事会 Erythroferrone和erfe多肽以及调控铁代谢的方法
WO2016048247A1 (en) * 2014-09-26 2016-03-31 National University Of Singapore Methods and compositions for modulating th-gm cell function

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
US7649098B2 (en) 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
US8138339B2 (en) * 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
ES2547916T3 (es) * 2011-02-18 2015-10-09 Novartis Pharma Ag Terapia de combinación de inhibidores de mTOR/JAK
AU2014339897A1 (en) * 2013-10-24 2016-04-21 Abbvie Inc. JAK1 selective inhibitor and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104854130A (zh) * 2012-11-01 2015-08-19 加利福尼亚大学董事会 Erythroferrone和erfe多肽以及调控铁代谢的方法
WO2016048247A1 (en) * 2014-09-26 2016-03-31 National University Of Singapore Methods and compositions for modulating th-gm cell function

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KR102707515B1 (ko) 2024-09-19
JP2020520374A (ja) 2020-07-09
AU2018270772B2 (en) 2024-06-06
JP7493939B2 (ja) 2024-06-03
KR20200007876A (ko) 2020-01-22
TW201900215A (zh) 2019-01-01
EP3628006A1 (en) 2020-04-01
US20230364072A1 (en) 2023-11-16
US20200306235A1 (en) 2020-10-01
CA3063100A1 (en) 2018-11-22
AU2018270772A1 (en) 2019-12-19
US11612595B2 (en) 2023-03-28
WO2018213027A1 (en) 2018-11-22
CN117085015A (zh) 2023-11-21
TWI850196B (zh) 2024-08-01
EP3628006A4 (en) 2021-07-21

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