CN111012690A - Lip balm and preparation method thereof - Google Patents

Lip balm and preparation method thereof Download PDF

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Publication number
CN111012690A
CN111012690A CN202010016448.8A CN202010016448A CN111012690A CN 111012690 A CN111012690 A CN 111012690A CN 202010016448 A CN202010016448 A CN 202010016448A CN 111012690 A CN111012690 A CN 111012690A
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China
Prior art keywords
parts
lip
lip balm
weight
same
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Chinese (zh)
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魏鹏
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Shanghai Jinting Cosmetics Co Ltd
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Shanghai Jinting Cosmetics Co Ltd
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Priority to CN202010016448.8A priority Critical patent/CN111012690A/en
Publication of CN111012690A publication Critical patent/CN111012690A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/342Alcohols having more than seven atoms in an unbroken chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/001Preparations for care of the lips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

Abstract

The invention relates to the technical field of cosmetics, and in particular relates to a lip balm and a preparation method thereof. The lip balm at least comprises 20-35 parts of emollient, 20-35 parts of emulsifier, 8-20 parts of thickener, 15-25 parts of hydrogenated polyisobutene, 3-6 parts of C8-28 alkanol benzoate, 0.8-2 parts of biomimetic peptide, 1-3.5 parts of filling microsphere, 1.5-3 parts of film forming agent and 0.05-0.15 part of colorant according to parts by weight. The lip plumping lipstick prepared by the invention can stimulate the synthesis of lip collagen and glycosaminoglycan, maintain the elasticity of lip skin, enhance the water absorption and expansion capacity of the lip, increase the water retention capacity of the lip skin, instantly smooth wrinkle effect, has remarkable lip plumping effect and moisten the lip skin, remarkably improves the color rendering property and durability of the lipstick, shows excellent cold resistance and heat resistance stability, effectively repairs the barrier function of the lip skin, better protects the lip skin, and has the effects of resisting inflammation, preserving moisture, relieving itching, resisting aging and the like.

Description

Lip balm and preparation method thereof
Technical Field
The invention relates to the technical field of cosmetics, and in particular relates to a lip balm and a preparation method thereof.
Background
The skin of the lips has no hair follicles and sebaceous glands, and cannot secrete sebum to moisturize and protect the skin. The only source of moisture is saliva, so the lips are cracked due to winter, cold wind, sunlight, dryness, and indoor and outdoor temperature differences. Lip care is a common demand of modern female consumer groups, and the lipstick capable of effectively moistening the lips, preventing water loss, improving the conditions of dryness, peeling and the like of the lips is produced at the same time. The lip balm is a necessary cosmetic in daily life, can make lips soft and glossy after being used, can keep the lips of people moist and moist for a long time, and meanwhile, can relieve and repair the skin of the lips and prevent adverse phenomena of dryness, peeling, cracking and the like of the lips. Compared with the skin of the face, the skin of the lips has the characteristics: 1. is relatively thin; 2. no sweat glands; 3. no sebaceous glands; 4. poor barrier function. Because of these characteristics of the lips, it dries easily, ages faster, loses elasticity easily, becomes less contoured, thins, ages, and loses gloss.
The traditional lip balm is generally a solid stick lip balm and mainly comprises wax and common grease, wherein the wax comprises vaseline, lanoline, liquid paraffin, beeswax and the like, wherein the wax has strong adsorbability, heavy feeling and poor air permeability, and can cause contact dermatitis after long-term application. The solid lipstick has the biggest limitation that water-soluble active ingredients cannot be loaded, so that the moisturizing effect on lips is insufficient.
At present, common lip balms on the market are various in types, but the function is single, no lipstick with good lip plumping effect is available, most of the lip balms have the problems of poor stability, poor absorption, irritation and the like, and the requirement for lip care cannot be met. Therefore, the development of the lip plumping cream which has high moistening degree and good lip plumping effect is needed to meet the requirements of different crowds and different occasions.
Disclosure of Invention
In order to solve the problems, the invention provides a lip balm in a first aspect, which at least comprises 20-35 parts of an emollient, 20-35 parts of an emulsifier, 8-20 parts of a thickener, 15-25 parts of hydrogenated polyisobutene, 3-6 parts of C8-28 alkanol benzoate, 0.8-2 parts of biomimetic peptide, 1-3.5 parts of filling microspheres, 1.5-3 parts of a film forming agent and 0.05-0.15 part of a colorant in parts by weight.
As a preferred embodiment, the emollient is selected from any one or combination of jojoba seed oil, shea butter, mango seed oil, phytosterol/octyldodecanol lauroyl glutamate, phytosterol oleate, diisostearyl malate, bis-diglycerol polyacyladipate-2, pentaerythritol tetrakis (ethyl hexanoate), pentaerythritol tetraisostearate, bis-behenyl/isostearyl/phytosterol dimer linoleate, propylene glycol dibenzoate, neopentyl glycol diheptanoate, isohexadecane, tridecyl alcohol trimellitate, isopropyl myristate, argania spinosa oil.
As a preferred embodiment, the biomimetic peptide comprises any one of palmitoyl tripeptide, palmitoyl hexapeptide, palmitoyl tetrapeptide, palmitoyl pentapeptide, myristoyl hexapeptide, myristoyl pentapeptide, acetyl octapeptide, acetyl hexapeptide, acetyl heptapeptide, and acetyl tetrapeptide.
As a preferred technical solution, the palmitoyl tripeptide is selected from any one or more of palmitoyl tripeptide-1, palmitoyl tripeptide-3, palmitoyl tripeptide-5, palmitoyl tripeptide-8, and palmitoyl tripeptide-38.
As a preferred technical scheme, the mass ratio of the bionic peptide to the filled microspheres is 1: (1.25-1.75).
As a preferred technical scheme, the emulsifier is selected from any one or more of phenyl trimethicone, dipentaerythritol tri-polyhydroxy stearate, caprylic/capric triglyceride, ethylhexyl palmitate, octyldodecanol, polydimethylsiloxane PEG-10/15 cross-linked polymer, PEG-10 polydimethylsiloxane, PEG-10 methyl ether polydimethylsiloxane, sodium lauryl sulfate, sodium lauryl ether sulfate, alkylbenzene sulfonate, alkyl phosphate and sodium fatty acyl isethionate.
As a preferred technical solution, the thickening agent is selected from any one or more of polyethylene, synthetic wax, microcrystalline wax, candelilla wax, beeswax, carnauba wax, vitamins, dibutyl lauroyl glutamine, dibutyl ethylhexanoyl glutamine.
As a preferable technical scheme, the lip balm further comprises 1-3 parts of antioxidant, 0.4-0.8 part of preservative and 1.5-4.5 parts of flavoring agent by weight.
As a preferred technical scheme, the antioxidant is selected from any one or combination of a plurality of white chinlon oil, vitamin E, vitamin C, catechin and oryzanol.
The invention provides a preparation method of the lip plumping lipstick, which comprises the following steps:
(1) sequentially adding a thickening agent, hydrogenated polyisobutene, five sixteenth parts by weight of an emulsifier and a film forming agent into a reaction tank, and heating to 80-90 ℃ until the materials are completely melted;
(2) adding one half of emollient by weight into a reaction tank, stirring, and keeping the temperature at 75-85 ℃ to obtain a first mixed reaction solution;
(3) heating C8-28 alkanol benzoate to 80 ℃, dissolving, adding into the first mixed reaction liquid in the step (2) while stirring, and uniformly stirring to obtain a second mixed reaction liquid;
(4) adding the remaining half of the emollient in part by weight into the second mixed reaction solution in the step (3), and uniformly stirring to obtain a third mixed reaction solution;
(5) uniformly mixing the rest one sixth of the emulsifier and the colorant, grinding by a three-roll grinder, adding the mixture into the third mixed reaction liquid obtained in the step (4) after uniform grinding, and uniformly stirring to obtain a fourth mixed reaction liquid;
(6) and (3) sequentially adding the biomimetic peptide, the filling microspheres, the antioxidant, the flavoring agent and the preservative into the fourth mixed reaction liquid obtained in the step (5), uniformly stirring, defoaming in vacuum, filling, cooling and demolding to obtain the lip balm.
Has the advantages that: the lip balm prepared by the invention adopts the bionic peptide to stimulate the synthesis of collagen and glycosaminoglycan in the lips and keep the elasticity of the skin of the lips; the filling microspheres are adopted to enhance the water absorption and expansion capacity of the lips, increase the water retention capacity of the skin of the lips, instantly smooth the wrinkle effect, achieve an obvious lip plumping effect and moisten the skin of the lips; through the unique cooperativity among all the formulas, the lip skin is endowed with very high adhesiveness and staining property, the dispersibility of the colorant is improved, and the color development and the durability of the lipstick are obviously improved; the lip balm prepared by the invention has excellent cold resistance and heat resistance stability, can effectively repair the barrier function of the lip skin, better protects the lip skin, and has the effects of resisting inflammation, preserving moisture, relieving itching, resisting aging and the like.
Detailed Description
The technical features of the technical solutions provided by the present invention are further clearly and completely described below with reference to the specific embodiments, and the scope of protection is not limited thereto.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when the range "1 to 5" is disclosed, the described range should be construed as including the ranges "1 to 4", "1 to 3", "1 to 2", "2 to 3" and "3 to 4", "4 to 5" and "3 to 5", etc. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
In order to solve the problems, the invention provides a lip balm in a first aspect, which at least comprises 20-35 parts of an emollient, 20-35 parts of an emulsifier, 8-20 parts of a thickener, 15-25 parts of hydrogenated polyisobutene, 3-6 parts of C8-28 alkanol benzoate, 0.8-2 parts of biomimetic peptide, 1-3.5 parts of filling microspheres, 1.5-3 parts of a film forming agent and 0.05-0.15 part of a colorant in parts by weight.
In a preferred embodiment, the lip balm at least comprises 27.5 parts of emollient, 26.5 parts of emulsifier, 12 parts of thickener, 21 parts of hydrogenated polyisobutene, 4 parts of C8-28 alkanol benzoate, 1 part of bionic peptide, 1.5 parts of filled microspheres, 1.9 parts of film forming agent and 0.1 part of colorant in parts by weight.
Skin-moistening agent
In one embodiment, the emollient is selected from the group consisting of any one or combination of jojoba seed oil, shea butter, mango seed oil, phytosterol/octyldodecanol lauroyl glutamate, phytosterol oleate, diisostearyl malate, bis-diglycerol polyacyladipate-2, pentaerythritol tetrakis (ethylhexanoate), pentaerythritol tetraisostearate, bis-behenyl/isostearyl/phytosterol dimer linoleate, propylene glycol dibenzoate, neopentyl glycol diheptanoate, isohexadecane, tridecyl alcohol trimellitate, isopropyl myristate, argan nut oil.
In a preferred embodiment, the emollient is selected from the group consisting of jojoba seed oil, shea butter, mango seed oil, phytosterol/octyldodecanol lauroyl glutamate, phytosterol oleate, diisostearyl malate, bis-diglycerol polyacyladipate-2, pentaerythritol tetrakis (ethyl hexanoate), pentaerythritol tetraisostearate, bis-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleate in any one or more combinations.
In a preferred embodiment, the emollient is a mixture of jojoba seed oil, shea butter, mango seed oil, phytosterol/octyldodecanol lauroyl glutamate, phytosterol oleate, diisostearyl malate, bis-diglycerol polyacyladipate-2, pentaerythritol tetrakis (ethyl hexanoate), pentaerythritol tetraisostearate, bis-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleate.
In a preferred embodiment, the weight ratio of jojoba seed oil, shea butter, mango seed oil, phytosterol/octyldodecanol lauroyl glutamate, phytosterol oleate, diisostearyl malate, bis-diglycerol polyacyladipate-2, pentaerythritol tetrakis (ethylhexanoate), pentaerythritol tetraisostearate, bis-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleate is 1: 1: 1: 0.95: 0.5: 7.62: 4.76: 3: 3.8: 3.8.
the Huohuba seed oil is DW JOJOBA COLORLESS, and is purchased from Nanjing Chenglong chemical Co.
The jojoba seed oil is rich in vitamin D and protein, is good moistening and moisturizing oil, can maintain skin moisture, prevent wrinkles and soften skin, is suitable for mature and aged skin, and is commonly used for face and body massage and hair care.
The Shea butter is sold as Lipex Shea, and is purchased from Shanghai Xiehui industry development Co., Ltd.
The shea butter is extracted from the fruit of shea butter, contains rich unsaturated fatty acid, can enhance the moisture retention capacity of skin, and can moisten dry skin, namely skin with damaged cutin. Meanwhile, the fluidity of the product can be adjusted, the viscosity can be improved, and the sensory quality and the use skin feeling of the product can be improved.
The MANGO seed oil is JARPLEX MB35 MANGO BUTTER, and is purchased from Shanghai Bo Xue Kogyo Co.
The mango seed oil is an oil fraction derived from mango butter production, is an refined and deodorized soft, semisolid and amorphous yellow oily substance, can provide a comfortable skin softening effect, has a moisturizing effect, and can treat dry skin caused by sun exposure, wind blowing and water volatilization.
The phytosterol/octyldodecanol lauroyl glutamate was sold under the trademark Eldew PS-203, purchased from beijing division, Iwasa Cosfa, inc.
The phytosterol/octyldodecanol lauroyl glutamate is made of pure plants, is similar to hair Cell Membrane Complex (CMC) lipid, has the same platy liquid crystal structure with ceramide, has good moisturizing effect and has excellent water holding effect.
The phytosterol oleate is sold under the trademark Heaalites PEP and purchased from Xian Haishff bioengineering Co.
The phytosterol oleate PEP is prepared by esterifying phytosterol and vegetable oil fatty acid, is a white paste at normal temperature, and becomes a flowable clear oily liquid when heated to 45-50 ℃. The Heaalites PEP can greatly improve the skin feel of a terminal product, has very remarkable effects of anti-inflammation, red removal, repair, moistening and the like, is natural, mild, safe, non-irritant and non-allergenic.
The diisostearyl malate was under the brand name Cosmol 222, purchased from beijing division, inc (Iwasa Cosfa), international trade of kefir (shanghai).
The diisostearyl malate is liquid oil, has high viscosity, is colorless to light yellow and transparent, has no odor or has little special odor, and is widely used for adhesives.
The CAS number for the bis-diglycerol polyacyladipate-2 is 82249-33-0.
The pentaerythritol tetra (ethyl hexanoate) was sold under the brand name Salacos 5408 and purchased from beijing division (Iwasa Cosfa), a company of international trade in kefir (shanghai).
Pentaerythritol tetraisostearate, marketed under the reference PTIS, was purchased from Shanghai Dingding Industrial and trade company, Inc.
The pentaerythritol tetraisostearate is an emollient with excellent performance, can improve the moist feeling and smooth feeling of hair, and is not greasy after being used. The unique molecular structure of the skin care product makes the skin care product have very good air permeability.
The bis-behenyl alcohol/isostearyl alcohol/phytosterol dioleyl alcohol dilinoleate is available under the trademark PLANDOL-G, and is purchased from Shanghai hong Kong corporation, Inc.
Emulsifier
In one embodiment, the emulsifier is selected from the group consisting of any one or more of phenyl trimethicone, dipentaerythritol tri-polyhydroxystearate, caprylic/capric triglyceride, ethylhexyl palmitate, octyldodecanol, dimethicone PEG-10/15 crosspolymer, PEG-10 dimethicone, PEG-10 methyl ether dimethicone, sodium lauryl sulfate, sodium lauryl ether sulfate, alkyl benzene sulfonate, alkyl phosphate, sodium fatty acyl isethionate.
In a preferred embodiment, the emulsifier is selected from any one or combination of phenyl trimethicone, dipentaerythritol tri-polyhydroxystearate, caprylic/capric triglyceride, ethylhexyl palmitate, octyldodecanol.
In a preferred embodiment, the emulsifier is a mixture of phenyl trimethicone, dipentaerythritol tri-polyhydroxystearate, caprylic/capric triglyceride, ethylhexyl palmitate, octyldodecanol.
In a preferred embodiment, the mass ratio of phenyl trimethicone, dipentaerythritol tri-polyhydroxystearate, caprylic/capric triglyceride, ethylhexyl palmitate, octyldodecanol is 1.6: 1: 1: 1: 1.
the phenyl trimethicone is available under the trademark DC556 and is purchased from Shanghai Fangdeng chemical Co., Ltd.
The phenyl trimethyl siloxane is defoaming, antistatic, soft and moist, reduces surface tension, enables the product to be fresh and clean, is easy to apply, is not sticky and has good compatibility, is dissolved in most organic solvents such as mineral oil, alcohols and esters, has high refractive index, increases cream gloss, is non-volatile, is easy to prepare, is not oily or greasy, and is a good emollient, lubricating, soft and waterproof.
The dipentaerythritol tri-polyhydroxystearate is sold under the trademark Salacos WO-6 and is purchased from beijing division, Iwasa Cosfa, international trade company, seine (shanghai).
The dipentaerythritol tri-polyhydroxystearate is liquid oil, high in viscosity, colorless to yellowish transparent, basically odorless and has the effect of preventing lipsticks and oily foundation foundations from sweating.
The caprylic/capric triglyceride is sold under the trademark GTCC and purchased from Shanghai collaborative industry development, Inc.
The high-purity grease is prepared by esterifying caprylic/capric acid and glycerol. It is an excellent moisturizing oil, has good spreadability, and can make skin feel smooth but not greasy, and be easily absorbed by skin. Has good effect on the uniformity and the fineness of cosmetics and can ensure that the skin is smooth and glossy. The caprylic/capric triglyceride can be used as base material of moisturizing factor, cosmetic antifreeze, and homogenizing agent.
The ethylhexyl palmitate is available under the trade designation BARENATE 2EHP from Shanghai Dingqin.
The ethylhexyl palmitate is a higher alcohol fatty acid ester product, is colorless to light yellow transparent oily liquid, and is odorless and odorless. Has satisfactory skin moistening effect, has good affinity with skin, is easily absorbed by skin tissue, and can soften skin. The product can be used for skin to prevent water evaporation, keep skin moist, improve skin softness and luster, and has low freezing point, no greasy feeling and moistening effect.
The CAS number of the octyldodecanol is 5333-42-6.
The octyl dodecanol is used in cosmetics and external preparations, has the functions of an emulsifier and a lubricant, and has a transdermal acceleration function.
Thickening agent
In one embodiment, the thickening agent is selected from any one or combination of polyethylene, synthetic wax, microcrystalline wax, candelilla wax, beeswax, carnauba wax, vitamins, dibutyl lauroyl glutamine, dibutyl ethylhexanoyl glutamine.
In a preferred embodiment, the thickener is selected from any one or combination of polyethylene, synthetic wax, microcrystalline wax, candelilla wax.
In a preferred embodiment, the thickener is a mixture of polyethylene, synthetic wax, microcrystalline wax, candelilla wax.
In a preferred embodiment, the mass ratio of the polyethylene, the synthetic wax, the microcrystalline wax and the candelilla wax is 5.15: 1.72: 4.29: 0.86.
the polyethylene is sold under the trademark Performalene500 and purchased from Olympic New materials science and technology, Inc. of Shanghai.
The synthetic wax was sold under the designation 4180 synthetic wax, purchased from Ying moment trades (Shanghai) Inc.
The microcrystalline wax is sold under the brand name microcrystalline wax 3970 and is available from the microcrystalline wax company of Saxol, Germany.
The microcrystalline wax is used as an inactive substance for other ingredients such as vaseline to increase the lipid phase of emulsions and ointments. They are used for improving oil absorption and stability to meet hardness of formulations, or for hard and uniform tough oil components having low crystallization characteristics. The microcrystalline wax can improve the texture and hardness of stick-type cosmetic such as lipstick without excessive crystallization.
The candelilla wax is SP-75, purchased from Xinjie (Shanghai) International trade company Limited.
The candelilla wax is a brown vegetable wax extracted from a grass grown in Texas and Mexico. The candelilla wax contains a moderate resin component, has a low shrinkage rate, can be cured without increasing the melting point of other waxes when mixed with other waxes, has moisture resistance and excellent emulsifiability, and can improve the overall quality such as ductility, pigment dispersibility and anti-dropping property. Meanwhile, the lipstick has natural gloss, the lips feel very soft, and the candelilla wax also has good emulsifying property, gloss, transparency, moisture retention, release property and plasticity, and is also a good viscosity and hardness regulator.
Hydrogenated polyisobutenes
In the present invention, the hydrogenated polyisobutene is squalane, which is a hydrocarbon oil obtained by hydrogenating squalene extracted from the liver of deep-sea sharks, and is also called deep-sea shark liver oil. The animal oil and fat with excellent feeling is used, has better affinity to the skin, and has lower polarity and moderate spreadability. Moistening but not greasy, having good compatibility with mineral oil and most of the raw materials of nursing products, colorless, tasteless, nontoxic, chemically inert, bright and transparent.
In one embodiment, the hydrogenated polyisobutene is sold under the trademark L-14E, available from Vantagen Panalane, USA.
C8-28 Alkanol benzoate
In one embodiment, the C8-28 alkanol benzoate is C10-18 alkanol benzoate.
In a preferred embodiment, the C10-18 alkanol benzoate is C12-15 alkanol benzoate.
The C12-15 alkanol benzoate is Cosmacol EBI, available from Imperial department, Fine chemical Co., Ltd.
The C12-15 alkanol benzoate is easy to emulsify, is widely used in various creams, sun-protection creams and emulsions, can also be used in hair conditioner shampoos, can perform a synergistic effect with a cationic active agent to enhance the favorable effect of hair conditioning, and can ensure that dry hair is oily and not greasy.
Biomimetic peptides
In one embodiment, the biomimetic peptide comprises any of palmitoyl tripeptide, palmitoyl hexapeptide, palmitoyl tetrapeptide, palmitoyl pentapeptide, myristoyl hexapeptide, myristoyl pentapeptide, acetyl octapeptide, acetyl hexapeptide, acetyl heptapeptide, acetyl tetrapeptide.
In a preferred embodiment, the biomimetic peptide comprises a palmitoyl tripeptide.
In a preferred embodiment, the palmitoyl tripeptide is selected from the group consisting of palmitoyl tripeptide-1, palmitoyl tripeptide-3, palmitoyl tripeptide-5, palmitoyl tripeptide-8, palmitoyl tripeptide-38, or a combination of any one or more thereof.
In a preferred embodiment, the palmitoyl tripeptide is palmitoyl tripeptide-38.
In a preferred embodiment, the biomimetic peptide, purchased from Sederma corporation under the designation Volulip, INCI: palmitoyl tripeptide-38, cetearyl ethyl hexanoate, sorbitan isostearyl, purslane extraction, sucrose cocoate.
Filled microspheres
In one embodiment, the filled microspheres are purchased from BASF Latin America under the trademark StickSPF 30-Uitra Filling Spheres, having an INCI: ethylhexyl palmitate, trihydroxystearin, sodium hyaluronate and glucomannan.
In a preferred embodiment, the mass ratio of the bionic peptide to the filled microspheres is 1: (1.25-1.75).
In a preferred embodiment, the mass ratio of the bionic peptide to the filled microspheres is 1: 1.5.
the lipstick capable of effectively moistening the lips, preventing water loss and improving dry peeling of the lips is the key point of lip care, the inventor conducts experimental research on lip plumping lipstick, during the application it was surprisingly found that with a biomimetic peptide comprising palmitoyl tripeptide-38, cetearyl ethylhexanoate, isosorbide isostearate, portulaca oleracea extract, sucrose cocoate, and the filling microspheres containing ethylhexyl palmitate, trihydroxy stearin, sodium hyaluronate and glucomannan are selected, so that the prepared lipstick has good lip plumping effect, this is probably because biomimetic peptides can stimulate the synthesis of collagen and glycosaminoglycans in the lips, maintain the elasticity of the skin of the lips, the filling microspheres enhance the water absorption and expansion capability of the lips through a hydration technology, increase the water retention capability of the skin of the lips, instantly smooth the wrinkle effect, have an obvious lip plumping effect and moisten the skin of the lips. In the further research process, the inventor unexpectedly finds that when the mass ratio of the bionic peptide to the filled microspheres is 1: (1.25-1.75), the components in the bionic peptide are easy to show all component unique cooperativity with jojoba seed oil, shea butter, mango seed oil, phytosterol/octyldodecanol lauroyl glutamate, phytosterol oleate, diisostearyl malate, di-diglycerol polyacyladipate-2, pentaerythritol tetra (ethyl hexanoate), pentaerythritol tetraisostearate, bis-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleate dimer, so that a very high adhesive property and staining property are provided for the lip skin, the dispersibility of the colorant is improved, and the color development and durability of the lipstick are obviously improved. In addition, surprisingly, a stable microsphere network structure is formed due to hydrogen bonding between sodium hyaluronate, glucomannan, palmitoyl tripeptide-38, purslane extractive, sucrose cocoate, phenoxyethanol, caprylyl glycol, octyldodecanol and the like in the filled microspheres, and the lipstick shows excellent cold resistance and heat resistance stability due to the synergistic effect of candelilla wax, jojoba seed oil, shea butter, mango seed oil, menthol and mint essence, effectively repairs the barrier function of the lip, better protects the lip skin, and has the effects of resisting inflammation, moisturizing, relieving itching, resisting aging and the like.
Film forming agent
In one embodiment, the film former is a VP hexadecene copolymer.
The VP/hexadecene copolymer is of the trade name
Figure BDA0002359065180000101
Purchased from ashland corporation, usa.
The VP/hexadecene copolymer is oil-soluble high-molecular glue, is used as a binder and a film-forming agent in cosmetics, and provides water resistance for sunscreen cream and other cosmetics.
Coloring agent
In one embodiment, the colorant is CI 45410 and/or CI 19140.
In a preferred embodiment, the colorant is a mixture of CI 45410 and CI 19140.
In a preferred embodiment, the mass ratio of CI 45410 to CI 19140 is 3: 16.
the molecular formula of CI 45410 is C20H2Br4Cl4Na2O5CAS number 4618-23-9.
The CI 19140 refers to lemon yellow No. 4 element, which is a chemical substance.
Lemon yellow is also called acid light yellow, tartrazine and hydrazine yellow. The chemical name is 1- (4-sulfophenyl) -4- (4-sulfophenylazo) -5-pyrazolone-3-carboxylic acid trisodium salt, and the CAS number is 1934-21-0. It is bright and bright yellow and is a monochromatic variety. Is a water-soluble synthetic pigment. The dye is generally used for dyeing food, beverage, medicine, cosmetics, feed, tobacco, toys, food packaging materials and the like, and is also used for dyeing wool and silk and producing color lake. An appropriate amount of lemon yellow can be safely used for coloring foods, beverages, medicines, cosmetics, feeds, tobacco, toys, food packaging materials, and the like. The synthetic pigments allowed for use in china are amaranth, carmine, lemon yellow, sunset yellow and indigo.
In a preferred embodiment, the lip balm further comprises 1-3 parts by weight of antioxidant, 0.4-0.8 part by weight of preservative and 1.5-4.5 parts by weight of flavoring agent.
In a preferred embodiment, the lip balm further comprises 1.5 parts by weight of antioxidant, 0.6 part by weight of preservative and 1.95 parts by weight of flavoring agent.
Antioxidant agent
In one embodiment, the antioxidant is selected from any one or combination of meadowfoam seed oil, vitamin E, vitamin C, catechins, oryzanol.
In a preferred embodiment, the antioxidant is a mixture of meadowfoam seed oil and vitamin E.
In a preferred embodiment, the mass ratio of the meadowfoam seed oil to the vitamin E is 2: 1.
the white Poissa SEED OIL is sold under the brand name FANCOR MEADOWFOAM SEED OIL and purchased from Elementiss specialties, Inc.
The meadowfoam seed oil contains more than 98% of long-chain fatty acid with an antioxidant effect and excellent emollient, and creates gorgeous texture for products. Soft and dry skin feel.
The vitamin E brand is d- α -tocopherol, and is purchased from Shanghai Yunyi Biotech, Inc.
Preservative
In one embodiment, the preservative is selected from any one or a combination of more of PHG preservatives, sorbic acid, potassium sorbate.
In a preferred embodiment, the preservative is a PHG preservative, available from toler international trade (shanghai) ltd, inc: phenoxyethanol and caprylyl glycol.
The preservative does not contain a paraben preservative, and is safe and non-irritant.
Flavoring agent
In one embodiment, the flavoring agent is selected from one or more of vanillyl butyl ether, menthol, and peppermint flavor.
In a preferred embodiment, the flavoring agent is a mixture of vanillyl butyl ether, menthol, and peppermint flavor.
In a preferred embodiment, the mass ratio of the vanillyl butyl ether to the menthol to the mint essence is 1: 3.5: 0.375.
the CAS number of the vanillyl butyl ether is 82654-98-6.
The CAS number of the menthol is 89-78-1.
The menthol is extracted from leaf and stem of herba Menthae, and has white crystal and molecular formula C10H20O, is the main component in peppermint and peppermint essential oils. Has cool, fresh and pleasant mint characteristic fragrance and sweet prickle smell. The fragrance gives people a cold feeling, the fragrance is thorough, but the fragrance is not lasting enough, and the taste is fresh, fresh and sweet.
The mint essence is food-grade mint essence, STS-111664, purchased from Fine chemical Co., Ltd of Shanghai Di Ke.
The raw materials for preparing the lip balm have no animal sources and no alcohol, so that the quality of the lip balm is ensured. The flavor is selected from mint flavor and a common lysimachia herb flavor. The lips are comfortable and durable to use, have strong stimulation but not too strong, and can be plump and naturally ruddy.
The invention provides a preparation method of the lip plumping lipstick, which comprises the following steps:
(1) sequentially adding a thickening agent, hydrogenated polyisobutene, five sixteenth parts by weight of an emulsifier and a film forming agent into a reaction tank, and heating to 80-90 ℃ until the materials are completely melted;
(2) adding one half of emollient by weight into a reaction tank, stirring, and keeping the temperature at 75-85 ℃ to obtain a first mixed reaction solution;
(3) heating C8-28 alkanol benzoate to 80 ℃, dissolving, adding into the first mixed reaction liquid in the step (2) while stirring, and uniformly stirring to obtain a second mixed reaction liquid;
(4) adding the remaining half of the emollient in part by weight into the second mixed reaction solution in the step (3), and uniformly stirring to obtain a third mixed reaction solution;
(5) uniformly mixing the rest one sixth of the emulsifier and the colorant, grinding by a three-roll grinder, adding the mixture into the third mixed reaction liquid obtained in the step (4) after uniform grinding, and uniformly stirring to obtain a fourth mixed reaction liquid;
(6) and (3) sequentially adding the biomimetic peptide, the filling microspheres, the antioxidant, the flavoring agent and the preservative into the fourth mixed reaction solution obtained in the step (5), homogenizing at a low speed, uniformly stirring, defoaming in vacuum, filling, cooling and demolding to obtain the lip balm.
In a preferred embodiment, the preparation method of the lip plumping lipstick comprises the following steps:
(1) sequentially adding a thickening agent, hydrogenated polyisobutene, five sixteenth parts by weight of an emulsifier and a film forming agent into a reaction tank, and heating to 85 ℃ until the materials are completely melted;
(2) adding one half of emollient by weight into a reaction tank, stirring, and keeping the temperature at 80 ℃ to obtain a first mixed reaction solution;
(3) heating C8-28 alkanol benzoate to 80 ℃, dissolving, adding into the first mixed reaction liquid in the step (2) while stirring, and uniformly stirring to obtain a second mixed reaction liquid;
(4) adding the remaining half of the emollient in part by weight into the second mixed reaction solution in the step (3), and uniformly stirring to obtain a third mixed reaction solution;
(5) uniformly mixing the rest one sixth of the emulsifier and the colorant, grinding by a three-roll grinder, adding the mixture into the third mixed reaction liquid obtained in the step (4) after uniform grinding, and uniformly stirring to obtain a fourth mixed reaction liquid;
(6) and (3) sequentially adding the biomimetic peptide, the filling microspheres, the antioxidant, the flavoring agent and the preservative into the fourth mixed reaction solution obtained in the step (5), homogenizing at a low speed, uniformly stirring, defoaming in vacuum, filling at 78 ℃, cooling, and demolding to obtain the lip plumping lipstick.
The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the starting materials used are all commercially available, unless otherwise specified.
Examples
Example 1
Example 1 provides a lip balm, wherein the lip balm comprises, by weight, 20 parts of an emollient, 20 parts of an emulsifier, 8 parts of a thickener, 15 parts of hydrogenated polyisobutene, 3 parts of C8-28 alkanol benzoate, 0.8 part of a biomimetic peptide, 1 part of filled microspheres, 1.5 parts of a film forming agent, 0.05 part of a colorant, 1 part of an antioxidant, 0.4 part of a preservative, and 1.5 parts of a flavoring agent;
the emollient is a mixture of jojoba seed oil, shea butter, mango seed oil, phytosterol/octyldodecanol lauroyl glutamate, phytosterol oleate, diisostearyl malate, di-diglycerol polyacyladipate-2, pentaerythritol tetra (ethylhexanoate), pentaerythritol tetraisostearate, di-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleate; the weight ratio of the jojoba seed oil, the shea butter, the mango seed oil, the phytosterol/octyldodecanol lauroyl glutamate, the phytosterol oleate, the diisostearyl malate, the di-diglycerol polyacyladipate-2, the pentaerythritol tetra (ethyl hexanoate), the pentaerythritol tetraisostearate, and the di-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleate is 1: 1: 1: 0.95: 0.5: 7.62: 4.76: 3: 3.8: 3.8 of the total weight of the mixture; the Huohouba seed oil is DW JOJOBA COLORLESS; the brand of the Shea butter is Lipex sheaa; the MANGO seed oil is JARPLEX MB35 MANGO BUTTER; the phytosterol/octyldodecanol lauroyl glutamate is sold as EldewPS-203; the grade of the phytosterol oleate is Heaalites PEP; the diisostearyl malate is under the trademark Cosmol 222; the CAS number of the di-diglycerol polyacyladipate-2 is 82249-33-0; the pentaerythritol tetra (ethyl hexanoate) is sold under the trade name Salacos 5408; pentaerythritol tetraisostearate is under the trademark PTIS; the grade of the bis-behenyl alcohol/isostearyl alcohol/phytosterol dioleyl alcohol dilinoleate is PLANDOL-G;
the emulsifier is a mixture of phenyl trimethicone, dipentaerythritol tri-polyhydroxy stearate, caprylic/capric triglyceride, ethylhexyl palmitate and octyldodecanol; the mass ratio of the phenyl trimethicone to the dipentaerythritol tri-polyhydroxystearate to the caprylic/capric triglyceride to the ethylhexyl palmitate to the octyldodecanol is 1.6: 1: 1: 1: 1; the phenyl trimethicone is under the trademark DC 556; the dipentaerythritol tri-polyhydroxystearate is sold under the trade name Salacos WO-6; the grade of the caprylic/capric triglyceride is GTCC; the ethylhexyl palmitate is BARENATE 2 EHP; the CAS number of the octyldodecanol is 5333-42-6;
the thickening agent is a mixture of polyethylene, synthetic wax, microcrystalline wax and candelilla wax; the mass ratio of the polyethylene to the synthetic wax to the microcrystalline wax to the candelilla wax is 5.15: 1.72: 4.29: 0.86 of the total weight of the mixture; the grade of the polyethylene is Performalene 500; the synthetic wax is 4180 synthetic wax; the microcrystalline wax is of the grade of microcrystalline wax 3970; the grade of the candelilla wax is SP-75;
the hydrogenated polyisobutene has a trade name of L-14E;
the C8-28 alkanol benzoate is C12-15 alkanol benzoate; the C12-15 alkanol benzoate is Cosmacol EBI;
the biomimetic peptide was purchased from Sederma corporation under the designation Volulip, INCI: palmitoyl tripeptide-38, cetearyl ethyl hexanoate, sorbitan isostearyl, portulaca pilosa extract, sucrose cocoate;
the filled microspheres were purchased from BASF Latin America. Under the trademark Stick SPF 30-UitraFilling Spheres, its INCI: ethylhexyl palmitate, trihydroxystearin, sodium hyaluronate, glucomannan;
the film-forming agent is VP/hexadecaneAn olefinic copolymer; the VP/hexadecene copolymer is of the trade name
Figure BDA0002359065180000151
The colorant is a mixture of CI 45410 and CI 19140; the mass ratio of the CI 45410 to the CI 19140 is 3: 16; the CAS number of the CI 45410 is the CAS number of 4618-23-9; the CAS number of the CI 19140 is 1934-21-0;
the antioxidant is a mixture of MEADOWFOAM SEED OIL and vitamin E, the mass ratio of the MEADOWFOAM SEED OIL to the vitamin E is 2: 1, the mark of the MEADOWFOAM SEED OIL is FANCOR MEADOOWFOAM SEED OIL, and the mark of the vitamin E is d- α -tocopherol;
the preservative was PHG preservative, purchased from toler international trade (shanghai) ltd, inc, with INCI: phenoxyethanol and caprylyl glycol;
the flavoring agent is a mixture of vanillyl butyl ether, menthol and mint essence; the mass ratio of the vanillyl butyl ether to the menthol to the mint essence is 1: 3.5: 0.375; the CAS number of the vanillyl butyl ether is 82654-98-6; the CAS number of the menthol is 89-78-1; the mint essence is food-grade mint essence and is marked as STS-111664.
The preparation method of the lip plumping lipstick comprises the following steps:
(1) sequentially adding a thickening agent, hydrogenated polyisobutene, five sixteenth parts by weight of an emulsifier and a film forming agent into a reaction tank, and heating to 85 ℃ until the materials are completely melted;
(2) adding one half of emollient by weight into a reaction tank, stirring, and keeping the temperature at 80 ℃ to obtain a first mixed reaction solution;
(3) heating C8-28 alkanol benzoate to 80 ℃, dissolving, adding into the first mixed reaction liquid in the step (2) while stirring, and uniformly stirring to obtain a second mixed reaction liquid;
(4) adding the remaining half of the emollient in part by weight into the second mixed reaction solution in the step (3), and uniformly stirring to obtain a third mixed reaction solution;
(5) uniformly mixing the rest one sixth of the emulsifier and the colorant, grinding by a three-roll grinder, adding the mixture into the third mixed reaction liquid obtained in the step (4) after uniform grinding, and uniformly stirring to obtain a fourth mixed reaction liquid;
(6) and (3) sequentially adding the biomimetic peptide, the filling microspheres, the antioxidant, the flavoring agent and the preservative into the fourth mixed reaction solution obtained in the step (5), homogenizing at a low speed, uniformly stirring, defoaming in vacuum, filling at 78 ℃, cooling, and demolding to obtain the lip plumping lipstick.
Example 2
Example 2 provides a lip balm, wherein the formula of the lip balm comprises, by weight, 35 parts of an emollient, 35 parts of an emulsifier, 20 parts of a thickener, 25 parts of hydrogenated polyisobutene, 6 parts of C8-28 alkanol benzoate, 2 parts of a biomimetic peptide, 3.5 parts of filled microspheres, 3 parts of a film forming agent, 0.15 part of a colorant, 3 parts of an antioxidant, 0.8 part of a preservative and 4.5 parts of a flavoring agent;
the emollient was the same as in example 1;
the emulsifier is as in example 1;
the thickener was the same as in example 1;
the hydrogenated polyisobutene has a trade name of L-14E;
the C8-28 alkanol benzoate is the same as in example 1;
the biomimetic peptide is as in example 1;
the filled microspheres are the same as in example 1;
the film forming agent is the same as in example 1;
the colorant is the same as in example 1;
the antioxidant was the same as in example 1;
the preservative was the same as in example 1;
the flavoring agent was the same as in example 1.
The lip balm was prepared as described in example 1.
Example 3
Example 3 provides a lip balm, wherein the lip balm comprises, by weight, 27.5 parts of an emollient, 26.5 parts of an emulsifier, 12 parts of a thickener, 21 parts of hydrogenated polyisobutene, 4 parts of C8-28 alkanol benzoate, 1 part of a biomimetic peptide, 1.5 parts of filled microspheres, 1.9 parts of a film forming agent, 0.1 part of a colorant, 1.5 parts of an antioxidant, 0.6 part of a preservative, and 1.95 parts of a flavoring agent;
the emollient was the same as in example 1;
the emulsifier is as in example 1;
the thickener was the same as in example 1;
the hydrogenated polyisobutene has a trade name of L-14E;
the C8-28 alkanol benzoate is the same as in example 1;
the biomimetic peptide is as in example 1;
the filled microspheres are the same as in example 1;
the film forming agent is the same as in example 1;
the colorant is the same as in example 1;
the antioxidant was the same as in example 1;
the preservative was the same as in example 1;
the flavoring agent was the same as in example 1.
The lip balm was prepared as described in example 1.
Example 4
Example 4 provides a lip balm, wherein the lip balm comprises, by weight, 27.5 parts of an emollient, 26.5 parts of an emulsifier, 12 parts of a thickener, 21 parts of hydrogenated polyisobutene, 4 parts of C8-28 alkanol benzoate, 0.1 part of a biomimetic peptide, 1.5 parts of filled microspheres, 1.9 parts of a film forming agent, 0.1 part of a colorant, 1.5 parts of an antioxidant, 0.6 part of a preservative, and 1.95 parts of a flavoring agent;
the emollient was the same as in example 1;
the emulsifier is as in example 1;
the thickener was the same as in example 1;
the hydrogenated polyisobutene has a trade name of L-14E;
the C8-28 alkanol benzoate is the same as in example 1;
the biomimetic peptide is as in example 1;
the filled microspheres are the same as in example 1;
the film forming agent is the same as in example 1;
the colorant is the same as in example 1;
the antioxidant was the same as in example 1;
the preservative was the same as in example 1;
the flavoring agent was the same as in example 1.
The lip balm was prepared as described in example 1.
Example 5
Example 5 provides a lip balm, wherein the lip balm comprises, by weight, 27.5 parts of an emollient, 26.5 parts of an emulsifier, 12 parts of a thickener, 21 parts of hydrogenated polyisobutene, 4 parts of C8-28 alkanol benzoate, 1 part of a biomimetic peptide, 0.2 part of filled microspheres, 1.9 parts of a film forming agent, 0.1 part of a colorant, 1.5 parts of an antioxidant, 0.6 part of a preservative, and 1.95 parts of a flavoring agent;
the emollient was the same as in example 1;
the emulsifier is as in example 1;
the thickener was the same as in example 1;
the hydrogenated polyisobutene has a trade name of L-14E;
the C8-28 alkanol benzoate is the same as in example 1;
the biomimetic peptide is as in example 1;
the filled microspheres are the same as in example 1;
the film forming agent is the same as in example 1;
the colorant is the same as in example 1;
the antioxidant was the same as in example 1;
the preservative was the same as in example 1;
the flavoring agent was the same as in example 1.
The lip balm was prepared as described in example 1.
Example 6
Example 6 provides a lip balm, wherein the lip balm comprises, by weight, 27.5 parts of an emollient, 26.5 parts of an emulsifier, 12 parts of a thickener, 21 parts of hydrogenated polyisobutene, 4 parts of C8-28 alkanol benzoate, 1 part of a biomimetic peptide, 1.5 parts of filled microspheres, 1.9 parts of a film forming agent, 0.1 part of a colorant, 1.5 parts of an antioxidant, 0.6 part of a preservative, and 1.95 parts of a flavoring agent;
the emollient was the same as in example 1;
the emulsifier is as in example 1;
the thickener was the same as in example 1;
the hydrogenated polyisobutene has a trade name of L-14E;
the C8-28 alkanol benzoate is the same as in example 1;
the bionic peptide is palmitoyl tripeptide-8; the CAS number of the palmitoyl tripeptide-8 is 936544-53-5;
the filled microspheres are the same as in example 1;
the film forming agent is the same as in example 1;
the colorant is the same as in example 1;
the antioxidant was the same as in example 1;
the preservative was the same as in example 1;
the flavoring agent was the same as in example 1.
The lip balm was prepared as described in example 1.
Example 7
Example 7 provides a lip balm, wherein the lip balm comprises, by weight, 27.5 parts of an emollient, 26.5 parts of an emulsifier, 12 parts of a thickener, 21 parts of hydrogenated polyisobutene, 4 parts of C8-28 alkanol benzoate, 1 part of a biomimetic peptide, 1.5 parts of filled microspheres, 1.9 parts of a film forming agent, 0.1 part of a colorant, 1.5 parts of an antioxidant, 0.6 part of a preservative, and 1.95 parts of a flavoring agent;
the emollient was the same as in example 1;
the emulsifier is as in example 1;
the thickener was the same as in example 1;
the hydrogenated polyisobutene has a trade name of L-14E;
the C8-28 alkanol benzoate is the same as in example 1;
the biomimetic peptide is as in example 1;
the filling microspheres are titanium dioxide; the titanium dioxide is food-grade titanium dioxide;
the film forming agent is the same as in example 1;
the colorant is the same as in example 1;
the antioxidant was the same as in example 1;
the preservative was the same as in example 1;
the flavoring agent was the same as in example 1.
The lip balm was prepared as described in example 1.
Example 8
Example 8 provides a lip balm, wherein the lip balm comprises, by weight, 27.5 parts of an emollient, 26.5 parts of an emulsifier, 12 parts of a thickener, 21 parts of hydrogenated polyisobutene, 4 parts of C8-28 alkanol benzoate, 1 part of a biomimetic peptide, 1.5 parts of filled microspheres, 1.9 parts of a film forming agent, 0.1 part of a colorant, 1.5 parts of an antioxidant, 0.6 part of a preservative, and 1.95 parts of a flavoring agent;
the emollient was the same as in example 1;
the emulsifier is as in example 1;
the thickening agent is a mixture of polyethylene, synthetic wax and microcrystalline wax; the mass ratio of the polyethylene to the synthetic wax to the microcrystalline wax is 5.15: 1.72: 4.29; the grade of the polyethylene is Performalene 500; the synthetic wax is 4180 synthetic wax; the microcrystalline wax is of the grade of microcrystalline wax 3970;
the C8-28 alkanol benzoate is the same as in example 1;
the biomimetic peptide is as in example 1;
the filled microspheres are the same as in example 1;
the film forming agent is the same as in example 1;
the colorant is the same as in example 1;
the antioxidant was the same as in example 1;
the preservative was the same as in example 1;
the flavoring agent was the same as in example 1.
The lip balm was prepared as described in example 1.
Example 9
Example 9 provides a lip balm, wherein the lip balm comprises, by weight, 27.5 parts of an emollient, 26.5 parts of an emulsifier, 12 parts of a thickener, 21 parts of hydrogenated polyisobutene, 4 parts of C8-28 alkanol benzoate, 1 part of a biomimetic peptide, 1.5 parts of filled microspheres, 1.9 parts of a film forming agent, 0.1 part of a colorant, 1.5 parts of an antioxidant, 0.6 part of a preservative, and 1.95 parts of a flavoring agent;
the emollient is a mixture of phytosterol/octyldodecanol lauroyl glutamate, phytosterol oleate, diisostearyl malate, bis-diglycerol polyacyladipate-2, pentaerythritol tetra (ethylhexanoate), pentaerythritol tetraisostearate, bis-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleate dimer; the mass ratio of the phytosterol/octyldodecanol lauroyl glutamate to the phytosterol oleate to the diisostearyl malate to the bis-diglycerol polyacyladipate 2 to the pentaerythritol tetra (ethylhexanoate) to the pentaerythritol tetraisostearate to the bis-behenyl alcohol/isostearyl alcohol/phytosterol dioleyl alcohol dilinoleate is 0.95: 0.5: 7.62: 4.76: 3: 3.8: 3.8 of the total weight of the mixture; the phytosterol/octyldodecanol lauroyl glutamate is sold as Eldev PS-203; the grade of the phytosterol oleate is Heaalites PEP; the diisostearyl malate is under the trademark Cosmol 222; the CAS number of the di-diglycerol polyacyladipate-2 is 82249-33-0; the pentaerythritol tetra (ethyl hexanoate) is sold under the trade name Salacos 5408; pentaerythritol tetraisostearate is under the trademark PTIS; the grade of the bis-behenyl alcohol/isostearyl alcohol/phytosterol dioleyl alcohol dilinoleate is PLANDOL-G;
the emulsifier is as in example 1;
the thickener was the same as in example 1;
the hydrogenated polyisobutene has a trade name of L-14E;
the C8-28 alkanol benzoate is the same as in example 1;
the biomimetic peptide is as in example 1;
the filled microspheres are the same as in example 1;
the film forming agent is the same as in example 1;
the colorant is the same as in example 1;
the antioxidant was the same as in example 1;
the preservative was the same as in example 1;
the flavoring agent was the same as in example 1.
The lip balm was prepared as described in example 1.
Example 10
Example 10 provides a lip balm, wherein the lip balm comprises, by weight, 27.5 parts of an emollient, 26.5 parts of an emulsifier, 12 parts of a thickener, 21 parts of hydrogenated polyisobutene, 4 parts of C8-28 alkanol benzoate, 1 part of a biomimetic peptide, 1.5 parts of filled microspheres, 1.9 parts of a film forming agent, 0.1 part of a colorant, 1.5 parts of an antioxidant, 0.6 part of a preservative, and 1.95 parts of a flavoring agent;
the emollient was the same as in example 1;
the emulsifier is a mixture of phenyl trimethicone, dipentaerythritol tri-polyhydroxy stearate, caprylic/capric triglyceride and ethylhexyl palmitate; the mass ratio of the phenyl trimethicone to the dipentaerythritol tri-polyhydroxystearate to the caprylic/capric triglyceride to the ethylhexyl palmitate is 1.6: 1: 1: 1; the phenyl trimethicone is under the trademark DC 556; the dipentaerythritol tri-polyhydroxystearate is sold under the trade name Salacos WO-6; the grade of the caprylic/capric triglyceride is GTCC; the ethylhexyl palmitate is BARENATE 2 EHP;
the thickener was the same as in example 1;
the hydrogenated polyisobutene has a trade name of L-14E;
the C8-28 alkanol benzoate is the same as in example 1;
the biomimetic peptide is as in example 1;
the filled microspheres are the same as in example 1;
the film forming agent is the same as in example 1;
the colorant is the same as in example 1;
the antioxidant was the same as in example 1;
the preservative was the same as in example 1;
the flavoring agent was the same as in example 1.
The lip balm was prepared as described in example 1.
Example 11
Example 11 provides a lip balm having a formulation including, in parts by weight, 27.5 parts of an emollient, 26.5 parts of an emulsifier, 12 parts of a thickener, 21 parts of hydrogenated polyisobutene, 4 parts of C8-28 alkanol benzoate, 1 part of a biomimetic peptide, 1.5 parts of filled microspheres, 1.9 parts of a film forming agent, 0.1 part of a colorant, 1.5 parts of an antioxidant, 0.6 part of a preservative, and 1.95 parts of a flavoring agent;
the emollient is glycerol;
the emulsifier is as in example 1;
the thickener was the same as in example 1;
the hydrogenated polyisobutene has a trade name of L-14E;
the C8-28 alkanol benzoate is the same as in example 1;
the biomimetic peptide is as in example 1;
the filled microspheres are the same as in example 1;
the film forming agent is the same as in example 1;
the colorant is the same as in example 1;
the antioxidant was the same as in example 1;
the preservative was the same as in example 1;
the flavoring agent was the same as in example 1.
The lip balm was prepared as described in example 1.
Example 12
Example 12 provides a lip balm having a formulation including, in parts by weight, 2 parts of a skin moisturizer, 26.5 parts of an emulsifier, 12 parts of a thickener, 21 parts of hydrogenated polyisobutylene, 4 parts of C8-28 alkanol benzoate, 1 part of a biomimetic peptide, 1.5 parts of filled microspheres, 1.9 parts of a film former, 0.1 part of a colorant, 1.5 parts of an antioxidant, 0.6 part of a preservative, and 1.95 parts of a flavoring agent;
the emollient was the same as in example 1;
the emulsifier is as in example 1;
the thickener was the same as in example 1;
the hydrogenated polyisobutene has a trade name of L-14E;
the C8-28 alkanol benzoate is the same as in example 1;
the biomimetic peptide is as in example 1;
the filled microspheres are the same as in example 1;
the film forming agent is the same as in example 1;
the colorant is the same as in example 1;
the antioxidant was the same as in example 1;
the preservative was the same as in example 1;
the flavoring agent was the same as in example 1.
The lip balm was prepared as described in example 1.
Performance testing
1. Lip plumping effect: 12 female volunteers 25 years old having thin lips and the same dryness were selected, applied with the lip plumping lipstick described in examples 1 to 12 three times a day for 30 consecutive days, subjected to human body test for 30 days to clinically evaluate the lip wrinkle and the wetness, the lip wrinkle and the wetness before use and 30 days after use of the lip plumping lipstick described in examples 1 to 12 were recorded, and the amount of decrease in the lip wrinkle and the increase in the wetness after 30 days using the lip plumping lipstick described in examples 1 to 12 were calculated, and the experimental results are shown in Table 1.
2. Durability of color development: selecting 12 female volunteers 25 years old with thin lips and the same dryness, respectively applying the lip plumping lipsticks of examples 1-12, and visually observing whether the color of the lips after 12 hours of application is consistent with the color of the lips during application; the results of the test are shown in Table 1, with 3 for no discoloration, 2 for small amount of discoloration and 1 for discoloration.
3. Heat resistance stability: placing the lip plumping lipsticks of examples 1 to 12 in an incubator at 45 ℃ for 24 hours, and observing whether the lip plumping lipsticks of examples 1 to 12 are bent and softened at 45 ℃ and return to 20 ℃ to be normally used; no bending softening is indicated as 5, a little bending softening is indicated as 4, partial bending softening is not indicated as 3, more bending dyeing is not indicated as 2, complete bending softening is not indicated as 1, and the experimental results are shown in table 1.
4. Cold resistance stability: the lip plumes of examples 1 to 12 were placed in an incubator at-15 ℃ for 48 hours, and the lip plumes of examples 1 to 12 were observed for the presence or absence of cracks after returning to room temperature; the results of the test are shown in Table 1, with no cracks being 5, few cracks being 4, partial cracks being 3, many cracks being 2, and complete cracks being 1.
Table 1 results of performance testing
Figure BDA0002359065180000241
5. Immediate use feeling: 30 volunteers were selected and divided into 3 groups, 10 persons in each group were each applied with the lip plumping lipstick described in examples 1 to 3, the feeling of use even when the lip plumping lipstick described in examples 1 to 3 was applied for 1 hour was evaluated, the volunteers were scored for softness, heat durability, lip plumping, comfort, and gloss of lips, each total score was 10, and finally the average of the scores of the 10 volunteers was taken, and the experimental results are shown in table 2.
TABLE 2 immediate use sensing test results
Sense of softness and moistness Durability of thermal sensation Feeling of fullness in the lips Comfort feeling Gloss of lips
Example 1 9.5 10 8 9 9
Example 2 10 9.5 8.5 9.5 9.5
Example 3 10 9.5 8.5 9 10
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims (10)

1. The lip balm is characterized by at least comprising 20-35 parts of an emollient, 20-35 parts of an emulsifier, 8-20 parts of a thickener, 15-25 parts of hydrogenated polyisobutene, 3-6 parts of C8-28 alkanol benzoate, 0.8-2 parts of biomimetic peptide, 1-3.5 parts of filling microspheres, 1.5-3 parts of a film forming agent and 0.05-0.15 part of a coloring agent in parts by weight.
2. The lip balm of claim 1, wherein the emollient is selected from the group consisting of jojoba seed oil, shea butter, mango seed oil, phytosterol/octyldodecanol lauroyl glutamate, phytosterol oleate, diisostearyl malate, bis-diglycerol polyacyladipate-2, pentaerythritol tetra (ethyl hexanoate), pentaerythritol tetraisostearate, bis-behenyl/isostearyl/phytosterol dimer linoleate, propylene glycol dibenzoate, neopentyl glycol diheptanoate, isohexadecane, tridecyl trimellitate, isopropyl myristate, and any one or more combinations of argania spinosa oil.
3. The lip balm according to claim 1, wherein the biomimetic peptide comprises any one of palmitoyl tripeptide, palmitoyl hexapeptide, palmitoyl tetrapeptide, palmitoyl pentapeptide, myristoyl hexapeptide, myristoyl pentapeptide, acetyl octapeptide, acetyl hexapeptide, acetyl heptapeptide, and acetyl tetrapeptide.
4. The lip balm according to claim 3, wherein the palmitoyl tripeptide is selected from the group consisting of palmitoyl tripeptide-1, palmitoyl tripeptide-3, palmitoyl tripeptide-5, palmitoyl tripeptide-8, and palmitoyl tripeptide-38.
5. The lip balm according to claim 1, wherein the mass ratio of the bionic peptide to the filled microspheres is 1: (1.25-1.75).
6. The lip balm according to claim 1, wherein the emulsifier is selected from the group consisting of phenyl trimethicone, dipentaerythritol tri-hydroxystearate, caprylic/capric triglyceride, ethylhexyl palmitate, octyldodecanol, dimethicone PEG-10/15 crosspolymer, PEG-10 dimethicone, PEG-10 methyl ether dimethicone, sodium lauryl sulfate, sodium lauryl ether sulfate, alkylbenzene sulfonate, alkyl phosphate, sodium fatty acyl isethionate, in combination with any one or more thereof.
7. The lip balm according to any one of claims 1-6, wherein the thickener is selected from the group consisting of any one or more of polyethylene, synthetic wax, microcrystalline wax, candelilla wax, beeswax, carnauba wax, vitamins, dibutyl lauroyl glutamine, dibutyl ethylhexanoyl glutamine.
8. The lip balm according to any one of claims 1 to 6, further comprising 1 to 3 parts by weight of an antioxidant, 0.4 to 0.8 part by weight of a preservative, and 1.5 to 4.5 parts by weight of a flavoring agent.
9. The lip balm according to claim 8, wherein the antioxidant is selected from any one or more of meadowfoam seed oil, vitamin E, vitamin C, catechin, and oryzanol.
10. A method of preparing a lip balm according to claim 8, comprising the steps of:
(1) sequentially adding a thickening agent, hydrogenated polyisobutene, five sixteenth parts by weight of an emulsifier and a film forming agent into a reaction tank, and heating to 80-90 ℃ until the materials are completely melted;
(2) adding one half of emollient by weight into a reaction tank, stirring, and keeping the temperature at 75-85 ℃ to obtain a first mixed reaction solution;
(3) heating C8-28 alkanol benzoate to 80 ℃, dissolving, adding into the first mixed reaction liquid in the step (2) while stirring, and uniformly stirring to obtain a second mixed reaction liquid;
(4) adding the remaining half of the emollient in part by weight into the second mixed reaction solution in the step (3), and uniformly stirring to obtain a third mixed reaction solution;
(5) uniformly mixing the rest one sixth of the emulsifier and the colorant, grinding by a three-roll grinder, adding the mixture into the third mixed reaction liquid obtained in the step (4) after uniform grinding, and uniformly stirring to obtain a fourth mixed reaction liquid;
(6) and (3) sequentially adding the biomimetic peptide, the filling microspheres, the antioxidant, the flavoring agent and the preservative into the fourth mixed reaction liquid obtained in the step (5), uniformly stirring, defoaming in vacuum, filling, cooling and demolding to obtain the lip balm.
CN202010016448.8A 2020-01-08 2020-01-08 Lip balm and preparation method thereof Withdrawn CN111012690A (en)

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CN111388397A (en) * 2020-04-26 2020-07-10 浙江维雅化妆品有限公司 Moisturizing and nourishing lipstick cream and preparation method thereof
CN111557864A (en) * 2020-05-18 2020-08-21 珠海市嘉琪精细化工有限公司 Make-up-holding and moisturizing lipstick and preparation method thereof
CN112618418A (en) * 2020-12-29 2021-04-09 娇时日化(杭州)股份有限公司 Lip color cosmetic and preparation method thereof
CN113081872A (en) * 2021-04-14 2021-07-09 广州花出见生物科技有限公司 Moistening and lasting lipstick
CN114044803A (en) * 2022-01-12 2022-02-15 浙江湃肽生物有限公司深圳分公司 Acetyl hexapeptide-1 derivative and application thereof
CN114099374A (en) * 2021-12-23 2022-03-01 娇时日化(杭州)股份有限公司 Lip essence cream and preparation method thereof
CN114306143A (en) * 2022-01-10 2022-04-12 广州睿新生物科技有限公司 Composition with lip enlarging and moistening functions and preparation method thereof
CN115006335A (en) * 2022-06-16 2022-09-06 浙江颜雪化妆品有限公司 Lip gloss with repairing function and preparation method thereof
CN115770201A (en) * 2021-09-09 2023-03-10 科丝美诗株式会社 Oil-dispersed stick cosmetic composition comprising vegetable butter
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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111388397A (en) * 2020-04-26 2020-07-10 浙江维雅化妆品有限公司 Moisturizing and nourishing lipstick cream and preparation method thereof
CN111557864A (en) * 2020-05-18 2020-08-21 珠海市嘉琪精细化工有限公司 Make-up-holding and moisturizing lipstick and preparation method thereof
CN111557864B (en) * 2020-05-18 2023-03-31 珠海市嘉琪精细化工有限公司 Make-up-holding and moisturizing lipstick and preparation method thereof
CN112618418A (en) * 2020-12-29 2021-04-09 娇时日化(杭州)股份有限公司 Lip color cosmetic and preparation method thereof
CN112618418B (en) * 2020-12-29 2022-09-02 娇时日化(杭州)股份有限公司 Lip color makeup and preparation method thereof
CN113081872A (en) * 2021-04-14 2021-07-09 广州花出见生物科技有限公司 Moistening and lasting lipstick
CN115770201A (en) * 2021-09-09 2023-03-10 科丝美诗株式会社 Oil-dispersed stick cosmetic composition comprising vegetable butter
CN114099374A (en) * 2021-12-23 2022-03-01 娇时日化(杭州)股份有限公司 Lip essence cream and preparation method thereof
CN114306143A (en) * 2022-01-10 2022-04-12 广州睿新生物科技有限公司 Composition with lip enlarging and moistening functions and preparation method thereof
CN114044803A (en) * 2022-01-12 2022-02-15 浙江湃肽生物有限公司深圳分公司 Acetyl hexapeptide-1 derivative and application thereof
CN115006335A (en) * 2022-06-16 2022-09-06 浙江颜雪化妆品有限公司 Lip gloss with repairing function and preparation method thereof
CN115813806A (en) * 2022-12-07 2023-03-21 广州真如化妆品有限公司 Lip and cheek dual-purpose liquid with effects of enlarging lips and firming apple muscles and preparation method thereof

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