CN111000765A - Whitening composition containing ginseng enzyme and application thereof - Google Patents
Whitening composition containing ginseng enzyme and application thereof Download PDFInfo
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- CN111000765A CN111000765A CN201911260398.1A CN201911260398A CN111000765A CN 111000765 A CN111000765 A CN 111000765A CN 201911260398 A CN201911260398 A CN 201911260398A CN 111000765 A CN111000765 A CN 111000765A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention discloses a whitening composition containing ginseng ferment, which comprises, by mass, α -arbutin 5% -15%, nicotinamide 50% -90% and ginseng ferment 5% -15%.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a whitening composition containing ginseng ferment and application thereof.
Background
Since ancient times, Asian women, especially oriental women, have a beautifying concept of 'white covering ugly', and until now, whitening is still one of the hottest requirements of the makeup industry, and whitening-related skin care products have become one of the mainstream of efficacy cosmetics.
The skin color of a human body is determined by intricate and complex combinations of various factors such as the physiological surface state of the skin, blood flow, moisture, and pigment, and the most important factor among these factors is melanin. Melanin is a high molecular biological pigment mainly distributed in epidermal cells and keratinocytes of the human body, and when melanin is excessively accumulated, it causes problems such as spots and freckles on the skin.
Melanin is synthesized by melanocytes and is metabolized as follows: tyrosine forms dopa under the action of tyrosinase, then the dopa is converted into dopaquinone, and the dopaquinone is subjected to a series of oxidative isomerization and polymerization reactions to finally form melanin. After melanin is formed, it is loaded by melanosomes and migrates toward surrounding keratinocytes along the dendritic projection ends extended from melanocytes, thereby being taken up by the keratinocytes. As the skin is cornified, melanin is pushed to the surface of the skin and is discharged from the skin with the exfoliation of the stratum corneum, and melanin completes the entire process from production to metabolism. The influence of the target object on the skin color of a human body, namely the whitening effect of the target object can be judged by blocking the formation of melanin or any stage of the delivery process and measuring the change of the melanin content (namely the melanin inhibition rate) caused by the blocking.
Phenylthiourea (PTU) is one of the best known tyrosinase inhibitors. The sulfur atom of PTU is combined with two copper ions of the active site of tyrosinase, and the activity of the enzyme is blocked, so that the synthetic process of melanin is cut off, and the melanin content is effectively reduced. Therefore, PTU is commonly used as a reference substance for skin whitening raw materials to measure the whitening efficacy of an object.
In addition to indirectly judging the whitening efficacy of a target substance by the melanin inhibition rate, it is a more direct judgment method by measuring the change in skin brightness. The Conicamidlata CR-400 chromatism meter is a certified successor of CR-100, CR-200 and CR-300 series, can be used for detecting the chromaticity of skin, expresses the whiteness of the skin by an L value, and measures the whitening effect of a target by a dL value (the difference of the L values after and before the treatment of the target). In addition to the data evidence of dL values, CR-400 also provides photographs of the skin to visualize changes in skin color.
Disclosure of Invention
In view of the above disadvantages, the present invention aims to provide a whitening composition containing ginseng ferment and application thereof, which have good whitening and melanin inhibiting effects.
The technical scheme of the invention is summarized as follows:
a whitening composition containing ginseng ferment is composed of the following components in parts by mass:
α -arbutin 5% -15%;
50% -90% of nicotinamide;
5-15% of ginseng enzyme.
Preferably, the whitening composition containing ginseng ferment comprises the following components in parts by mass:
α -arbutin 6% -12%;
60% -80% of nicotinamide;
6 to 12 percent of ginseng ferment.
A topical skin care composition comprises a whitening composition containing ginseng ferment.
Preferably, the external skin care preparation, wherein the α -arbutin is used in an amount of 0.1 wt% to 10 wt% based on the total weight of the external skin care preparation.
Preferably, the external skin care product is characterized in that the nicotinamide is used in the external skin care product in an amount of 0.1 wt% to 10 wt% based on the total weight of the external skin care product.
Preferably, the external skin care product is characterized in that the ginseng ferment is used in an amount of 0.1 wt% to 10 wt% based on the total weight of the external skin care product.
Preferably, the external skin care composition, wherein the external skin care preparation is in the form of at least one of cream, lotion, water, mask and bath agent.
A whitening moisturizing lotion containing ginseng ferment, which comprises the following components based on the total weight of the moisturizing lotion:
a whitening and moisturizing essence containing ginseng enzymes comprises the following components in percentage by weight based on the total weight of the moisturizing essence:
a whitening and moisturizing cream containing ginseng ferment, which comprises the following components in percentage by weight based on the total weight of the moisturizing cream:
the invention has the beneficial effects that:
the whitening composition disclosed by the invention has the advantages that the inhibition effect and the whitening effect on melanin are obvious by reasonably matching α -arbutin, nicotinamide and ginseng ferment, and the whitening composition has obvious advantages in the aspect of melanin reduction by adding moisturizing water, essence and moisturizing cream, and has obvious skin whitening and brightening effects.
Drawings
FIG. 1 is a graph comparing the amount of melanin reduction in the examples and the control;
fig. 2 is a graph comparing dL control rates of the example and control samples.
Detailed Description
The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.
The invention provides a whitening composition containing ginseng ferment, which comprises the following components in parts by mass:
α -arbutin 5% -15%;
50% -90% of nicotinamide;
5-15% of ginseng enzyme.
α -arbutin, also called as arbutin, is white needle-like crystal or powder, is extracted from the leaves of bearberry, can inhibit the activity of tyrosinase in vivo and prevent the generation of melanin, thereby reducing skin pigmentation, removing color spots and freckles, and simultaneously has the functions of sterilization and inflammation diminishing, nicotinamide is a derivative of vitamin B3, ginseng ferment has the functions of photooxidation resistance, skin aging resistance, free radical removal and the like, and can effectively prevent the skin from being aged, α -arbutin, nicotinamide and ginseng ferment have synergistic effect, so that the effects of whitening and preventing melanin are optimal.
As another embodiment of the present disclosure, the composition comprises the following components in parts by mass:
α -arbutin 6% -12%;
60% -80% of nicotinamide;
6 to 12 percent of ginseng ferment.
A topical skin care composition comprises a whitening composition containing ginseng ferment.
As another embodiment of the scheme, the α -arbutin is used in an amount of 0.1-10 wt% based on the total weight of the skin care product for external use.
As another embodiment of the present disclosure, the amount of niacinamide is 0.1 wt% to 10 wt% based on the total weight of the skin care product for external use.
As another embodiment of the disclosure, the ginseng ferment is used in an amount of 0.1 wt% to 10 wt% based on the total weight of the external skin care product.
As yet another embodiment herein, the skin care product for external use is in the form of at least one of a cream, a lotion, water, a mask, and a bath agent.
A whitening moisturizing lotion containing ginseng ferment, which comprises the following components based on the total weight of the moisturizing lotion:
the skin moisturizing liquid is colorless, transparent, odorless and sticky liquid, sweet in taste and hygroscopic, the oat β -glucan has an excellent anti-aging effect, can smooth fine wrinkles, improve skin elasticity and improve skin texture, has a unique linear molecular structure, endows good transdermal absorption performance, promotes fibroblasts to synthesize collagen, promotes wound healing, repairs damaged skin, and gives the skin a silky moist and smooth touch feeling, the trehalose has excellent characteristics of keeping cell vitality and biological macromolecule activity, skin cells, particularly epidermal cells are easy to lose moisture and keratinize under the environments of high temperature, high cold, dryness, strong ultraviolet radiation and the like, even die and fall off to damage the skin, the trehalose can form a special protective film on the cell surface layer under the condition, mucus precipitated from the film not only moistens the skin cells, but also has the function of radiating heat out, so that the skin is protected from being damaged, the erythritol is used as a moisturizing agent, the polyquaternium-51 is a high-molecular material, the moisturizing performance of the hyaluronic acid is 2 times of that the moisturizing property of the hyaluronic acid is colorless, the phenoxyethanol is colorless, has a sweet, tastes like, has a sweet, has a buffering effect of being added in slightly toxic, and can be used as a moisturizing solution capable of replacing sodium azide, and capable of improving the moisture of reducing the moisture of being absorbed in normal skin.
A whitening and moisturizing essence containing ginseng enzymes comprises the following components in percentage by weight based on the total weight of the moisturizing essence:
the glyceryl polyether-26 is obtained by polymerizing glycerin and ethylene oxide, belongs to nonionic surfactant-polyhydric alcohol polyoxyethylene ether, and is used as humectant and spreading agent of cosmetics; 1, 3-butanediol is used as a humectant and a softener; glucose is hygroscopic; rhamnose can be used as a humectant, and sodium hyaluronate has an excellent moisturizing effect; fucoidan has anti-irritant effect; sodium polyacryloyl dimethyl taurate is used as an emulsion stabilizer; acrylamide dimethyl ammonium taurate/VP copolymer as emulsifying thickener; phenoxyethanol is used as a preservative; the ethylhexyl glycerin is used as an emollient, a humectant and a wetting agent, and can improve the moisturizing effect of the formula and simultaneously has smooth skin feel.
A whitening and moisturizing cream containing ginseng ferment, which comprises the following components in percentage by weight based on the total weight of the moisturizing cream:
the glyceryl polyether-7 has excellent foam stabilizing, wetting, penetrating, lubricating, solubilizing and moisturizing capabilities; diglycerol is used as a humectant and a solvent; PEG-400 as a humectant and solubilizer; the acetyl chitosamine has excellent transdermal absorbability, can improve the hydration of skin, and is a high-quality multifunctional humectant; compared with other moisturizing agents, the sodium hyaluronate has small influence on the moisturizing performance due to the relative humidity of the surrounding environment and good moisturizing performance; the enzymolysis oligomeric sodium hyaluronate has strong lubricity and moisture retention; the hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer has the functions of emulsification and thickening; the glycerol stearate has good hydrolysis resistance and strong emulsifying property; the shea butter can promote the regeneration of epidermal cells and endow the skin with the nutrition function; the C10-18 fatty acid triglyceride is mainly used as an emollient and a skin conditioner, and has excellent water locking and thickening properties due to the combination of a large amount of solid fat and liquid grease, and a special chemical structure; the polydimethylsiloxane has a lubricating effect and good air permeability; VE acetate is an antioxidant to prevent the oxidation of the moisturizing cream; ascorbyl palmitate as an oxygen scavenger and synergist; the dioctyl carbonate has extremely dry skin feel and good spreadability; the phenoxyethanol has antibacterial effect; ethylhexyl glycerin is used as a humectant.
Specific examples and comparative examples are listed below:
example 1:
α -arbutin 10%;
80% of nicotinamide;
10% of ginseng ferment.
The whitening efficacy was tested according to the composition and proportions of example 1:
the first, experimental principle:
to verify the whitening efficacy of α -arbutin/niacinamide/ginseng ferment composition, we employed the following experimental method:
1. culturing recombinant Asian tanning skin epidermal layer cells, namely performing different treatment blank groups (without adding any test substance), solvent groups (adding a solvent for dissolving α -arbutin/nicotinamide/ginseng ferment composition), PTU groups (adding PTU) and α -arbutin/nicotinamide/ginseng ferment compositions on the recombinant skin cells, measuring the melanin content in the melanin cells of each group after culturing the cells for several days, calculating the melanin inhibition rate between each treatment group and the blank groups to show the whitening effect of each treatment substance, if α -arbutin/nicotinamide/ginseng ferment compositions are compared with the blank groups, the melanin inhibition rate data show a significant difference, that is, α -arbutin/nicotinamide/ginseng ferment compositions can reduce the generation of the total melanin amount and can be considered to have a significant whitening effect, if α -arbutin/nicotinamide/ginseng ferment compositions are compared with the blank groups, α -arbutin/nicotinamide/ginseng ferment compositions can further verify the whitening effect of the arbutin/ginseng ferment compositions by adopting Nicotiana CR-400 to measure the color difference of the skin color difference, and further verify the skin whitening effect of the skin by comparing the data of the α -arbutin/nicotinamide/ginseng ferment compositions with the blank groups 35dL, and calculating the skin whitening effect data show a significant difference, if the skin whitening effect of the skin is calculated by adopting a comparison result of the nikojicamb-arbutin/nicotinamide/ginseng enzyme compositions which is poor, and the skin is further, and the skin whitening effect of the skin is calculated by adopting a comparison of α, and the nikojic score of the;
3) the blank group, the solvent group, the PTU group and the α -arbutin/nicotinamide/ginseng ferment composition are photographed and compared in a mode of directly photographing by a Conicamideak CR-400 color difference meter, and the whitening effect of the α -arbutin/nicotinamide/ginseng ferment composition is judged through the visual perception of the photograph.
Second, Experimental methods
1. Cell culture and processing
The 3-D human epidermal layer recombinant skin containing human keratinocytes and melanocytes was placed on a sterilized agarose plate, seeded in a 6-well cell plate filled with 1.5ml of a medium, cultured overnight at 37 ℃ under 5% CO2, and the state of the cells was maintained as required (a blank well was set, only recombinant skin of the corresponding concentration was added to the blank well) for 24 hours, then 25ul of the test substance (including a separate solvent control, phenylthiourea of 3mM concentration and α -arbutin/nicotinamide/ginseng ferment composition of the corresponding concentration) diluted with PBS/20% ethanol solution was added to each of the other cell plates except the blank well, and the incubation was continued (37 ℃, 5% CO2), and the above operations were repeated on days 3 and 6, and the medium was changed.
2. Melanin content detection
After the recombinant skin is incubated for 8 days, the skin culture is collected respectively and placed in a 1.5ml centrifuge tube, 360 mul of melanin extracting solution is added, water bath is carried out for 45 minutes at 100 ℃, then 150 mul of solution is absorbed from each centrifuge tube twice and transferred into a 96-well plate, and the absorbance value at 490nm is measured by an enzyme-linked immunosorbent assay.
3. Calculation of melanin inhibition ratio
Melanin inhibition (%) was 100% (relative value of melanin content in sample/relative value of melanin content in blank control group)
4. Measurement of L value of recombined skin by Konika minolta CR-400 chromatism meter
The CR-400 colorimeter needs to be calibrated before testing. For the blank and cultured reconstituted skin after treatment with each treatment agent, the L values were tested on day 1 and day 8, respectively, and dL values and dL control rates were calculated.
dL ═ L8 (day 8L value) -L1 (day 1L value)
dL control (sample dL value/blank dL value) 100%
5. Photographing contrast of Konika minolta CR-400 color chromatometer
For the change of the recombinant skin before and after the treatment of each treatment agent, except for the comparison and the test of the L value, the change is photographed at the same time for visual comparison.
The experimental result of the melanin inhibition effect is shown in fig. 1, and compared with the blank group, the melanin inhibition rate of the 0.1% α -arbutin/1% nicotinamide/0.1% ginseng ferment composition is significantly different, and the melanin inhibition effect of the composition is close to that of a famous tyrosinase inhibitor PTU.
The dL control rate is shown in fig. 2, and the dL control rate of the recombinant skin cultured after the treatment of 0.1% α -arbutin/1% nicotinamide/0.1% ginseng ferment composition is very different from that of the blank group, which indicates that the recombinant skin has very significant skin whitening effect and is superior to the famous tyrosinase inhibitor PTU.
The recombined skin cultured after the blank group and each treatment agent are compared by photographing through a Conicamidta CR-400 chromatism meter, and the recombined skin cultured after the α -arbutin/nicotinamide/ginseng ferment composition is treated intuitively shows the obvious skin whitening effect.
Example 2:
a whitening moisturizing lotion containing ginseng ferment comprises the following components by weight:
example 3:
a whitening moisturizing lotion containing ginseng ferment comprises the following components by weight:
example 4:
a whitening moisturizing lotion containing ginseng ferment, which comprises the following components based on the total weight of the moisturizing lotion:
example 5:
a whitening and moisturizing essence containing ginseng ferment comprises the following components in percentage by weight based on the total weight of the moisturizing essence:
example 6:
a whitening and moisturizing essence containing ginseng ferment comprises the following components in percentage by weight based on the total weight of the moisturizing essence:
example 7:
a whitening and moisturizing essence containing ginseng ferment comprises the following components in percentage by weight based on the total weight of the moisturizing essence:
example 8:
a whitening and moisturizing cream containing ginseng ferment comprises the following components in percentage by weight based on the total weight of the moisturizing cream:
example 9:
a whitening and moisturizing cream containing ginseng ferment, which comprises the following components in percentage by weight based on the total weight of the moisturizing cream:
example 10:
a whitening and moisturizing cream containing ginseng ferment, which comprises the following components in percentage by weight based on the total weight of the moisturizing cream:
the test results for examples 2 to 4 are listed below:
TABLE 1
The test results for examples 5 to 7 are listed below:
TABLE 2
The test results for examples 8 to 10 are listed below:
TABLE 3
As can be seen from tables 1-3, the evaluation of the reduction of melanin by a human body shows that the sample of the embodiment has obvious advantages in terms of the reduction of melanin; the moisturizing lotion, essence and cream have obvious skin whitening and brightening effects by adding the whitening composition containing ginseng ferment.
While embodiments of the invention have been disclosed above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in all kinds of fields of application of the invention, and further modifications may readily be effected by those skilled in the art, so that the invention is not limited to the specific details without departing from the general concept defined by the claims and the scope of equivalents.
Claims (10)
1. The whitening composition containing ginseng ferment is characterized by comprising the following components in parts by mass:
α -arbutin 5% -15%;
50% -90% of nicotinamide;
5-15% of ginseng enzyme.
2. The ginseng ferment-containing whitening composition according to claim 1, which is characterized by comprising the following components in parts by mass:
α -arbutin 6% -12%;
60% -80% of nicotinamide;
6 to 12 percent of ginseng ferment.
3. A skin care composition for external use comprising the ginseng ferment-containing whitening composition according to claim 1 or 2.
4. The external skin care preparation according to claim 3, wherein α -arbutin is present in the external skin care preparation in an amount of 0.1-10 wt%, based on the total weight of the external skin care preparation.
5. The external skin care preparation according to claim 3, wherein the niacinamide is used in an amount of 0.1 wt% to 10 wt% based on the total weight of the external skin care preparation.
6. The external skin care product according to claim 3, wherein the ginseng ferment is used in an amount of 0.1 wt% to 10 wt% based on the total weight of the external skin care product.
7. The external skin care composition according to any one of claims 3 to 6, wherein the external skin care product is in the form of at least one of cream, lotion, essence, water, and mask.
8. A whitening moisturizing lotion containing ginseng ferment, which comprises the following components based on the total weight of the moisturizing lotion:
9. a whitening and moisturizing essence containing ginseng enzymes comprises the following components in percentage by weight based on the total weight of the moisturizing essence:
10. a whitening and moisturizing cream containing ginseng ferment, which comprises the following components in percentage by weight based on the total weight of the moisturizing cream:
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112438907A (en) * | 2020-11-05 | 2021-03-05 | 铂臻(广州)生物科技有限公司 | Eyebrow pencil and preparation method thereof |
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- 2019-12-10 CN CN201911260398.1A patent/CN111000765A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397183A (en) * | 2011-08-24 | 2012-04-04 | 珲春华瑞参业生物工程有限公司 | Ginseng and soapberry fermentation extract and its application in cosmetics |
| CN102366373A (en) * | 2011-11-04 | 2012-03-07 | 抚松参美化妆品有限公司 | Preparation method of ginseng fermenting extractive with enhanced whitening function |
| CN108653092A (en) * | 2018-07-05 | 2018-10-16 | 上海新高姿化妆品有限公司 | A kind of cosmetic composition with collaboration whitening effect |
| CN108969434A (en) * | 2018-07-31 | 2018-12-11 | 东莞市联洲知识产权运营管理有限公司 | A kind of ginseng small-molecular peptides gel and preparation method thereof and the application in cosmetics |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112438907A (en) * | 2020-11-05 | 2021-03-05 | 铂臻(广州)生物科技有限公司 | Eyebrow pencil and preparation method thereof |
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