CN104825804A - Skin-whitening, moisturizing and anti-aging composition, preparation method and application of same - Google Patents
Skin-whitening, moisturizing and anti-aging composition, preparation method and application of same Download PDFInfo
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- CN104825804A CN104825804A CN201410069356.0A CN201410069356A CN104825804A CN 104825804 A CN104825804 A CN 104825804A CN 201410069356 A CN201410069356 A CN 201410069356A CN 104825804 A CN104825804 A CN 104825804A
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Abstract
The invention provides a skin-whitening, moisturizing and anti-aging composition which is an external-use preparation prepared from following raw material medicines, by weight: 20-60 parts of bletilla striata, 15-35 parts of the root bark of white mulberry, 17-47 parts of radix pseudostellariae, 10-37 parts of periostracum cicada and 10-37 parts of lithospermum erythrorhizon. The composition is excellent in inhibition activity on tyrosinase, is strong in moisturizing effect and is long in lasting time, can effectively enhance skin elasticity. Meanwhile, in the composition, a synergistic effect is achieved due to reasonable compatibility of the traditional Chinese medicines according to a monarch-minister-assistant-guide principle, thereby achieving a better activity of inhibiting melanogenesis. The invention provides a new skin care product having the effects of eliminating stain, compacting skin and resisting wrinkle, and preserving moisture and whitening skin.
Description
Technical field
The present invention relates to a kind of whitening skin and preserving moisture anti-apolexis composition and its production and use.
Background technology
Tryrosinase is a kind of polyphenol oxidase, is the key enzyme in dermal melanin forming process, rate-limiting enzyme, and activity and the B16 cell amount of tryrosinase are proportionate, and its activity change can cause dyschromicum dermatosis.Tyrosinase inhibitor is active by restraint of tyrosinase, stops melanin to be formed, can be used to the diseases such as prevention and therapy pigmentation, chloasma, have broad application prospects at cosmetics and field of medicaments.
What be combined with modern science and technology research means along with Chinese herbal medicine develops rapidly, and the isolation identification of Effective Component of Chinese Medicine is trickleer, and its pharmacological action is more clear and definite, and medium-height grass the effective elements of the medicine is also widely used in cosmetics.How from Chinese medicine, to extract effective restraint of tyrosinase, the active component of moisturizing is research emphasis from now on and direction.
Summary of the invention
The object of the present invention is to provide a kind of whitening skin and preserving moisture anti-apolexis composition and its production and use.
The invention provides a kind of whitening skin and preserving moisture anti-apolexis composition, it is the external preparation be prepared from by the crude drug of following weight proportion:
The Pseudobulbus Bletillae (Rhizoma Bletillae) (also known as Pseudobulbus Bletillae (Rhizoma Bletillae)) 20-60 part, Cortex Mori 15-35 part, Radix Pseudostellariae 17-47 part, Periostracum Cicadae 10-37 part, Radix Arnebiae (Radix Lithospermi) 10-37 part.
Further, it is the external preparation be prepared from by the crude drug of following weight proportion:
Pseudobulbus Bletillae (Rhizoma Bletillae) 45-58 part, Cortex Mori 15-24 part, Radix Pseudostellariae 17-35 part, Periostracum Cicadae 11-23 part, Radix Arnebiae (Radix Lithospermi) 11-23 part.
Further, described compositions be with the water of each crude drug or/and ethanol extraction is for active component, add the adjuvant that pharmacy or cosmetics are commonly used or Supplementary active ingredients preparation and come preparation for external application to skin.
Further, described concentration of alcohol is 50-80%v/v.
Further, described complementary composition is collagen protein, hyaluronic acid sodium or vitamin.
Wherein, described external preparation is facial film, protective skin cream, emulsion, gel or astringent.
Present invention also offers above-mentioned composition and prepare the purposes in tyrosinase inhibitor.
Present invention also offers above-mentioned composition and prepare antiplaque, moisturizing, the crease-resistant or purposes that improves in the external use skin care of skin elasticity or medicine.
The present composition, good to the inhibit activities of tryrosinase, moisture-keeping function is strong, persistent period is long, effectively can strengthen skin elasticity, simultaneously, said composition uses monarch theory for instructing each Chinese crude drug reasonable compatibility, played synergistic function, there is more significant check melanin and generate active, provide a kind of have eliminate mottle, compact new skin care item that are crease-resistant, moisturizing whitening.
Detailed description of the invention
The preparation of embodiment 1 present composition
Get Pseudobulbus Bletillae (Rhizoma Bletillae) 58g, Cortex Mori 15g, Radix Pseudostellariae 17g, Periostracum Cicadae 11g, Radix Arnebiae (Radix Lithospermi) 11g, pulverize, after mixing, decoct with water 3 times, each 1.5h, merging filtrate, concentrated, gained extractum after dry, add suitable quantity of water, glycerol, Polyethylene Glycol, trehalose, EDETATE SODIUM again, be prepared into facial film, wherein, Effective Component of Chinese Medicine content is about 16% with crude drug gauge.
The preparation of embodiment 2 present composition
Get Pseudobulbus Bletillae (Rhizoma Bletillae) 45g, Cortex Mori 21g, Radix Pseudostellariae 21g, Periostracum Cicadae 15g, Radix Arnebiae (Radix Lithospermi) 15g, pulverize, after mixing, decoct with water 3 times, each 1.5h, merging filtrate, concentrated, gained extractum after dry, then add oil phase adjuvant conventional in suitable quantity of water and external preparation, be prepared into emulsion.
The preparation of embodiment 3 present composition
Get Pseudobulbus Bletillae (Rhizoma Bletillae) 58g, Cortex Mori 15g, Radix Pseudostellariae 17g, Periostracum Cicadae 11g, Radix Arnebiae (Radix Lithospermi) 11g, pulverize, after mixing, add 70%v/v alcohol reflux 2 times, each 1h, merge extractive liquid, after reclaiming ethanol, gained extractum after dry, then add suitable quantity of water and gel-type vehicle, be prepared into gel.
The preparation of embodiment 4 present composition
Get Pseudobulbus Bletillae (Rhizoma Bletillae) 49g, Cortex Mori 24g, Radix Pseudostellariae 35g, Periostracum Cicadae 23g, Radix Arnebiae (Radix Lithospermi) 23g, pulverize, after mixing, add 60%v/v ethanol ultrasonic extraction 3 times, each 15-20min, merge extractive liquid, after reclaiming ethanol, gained extractum after dry, add suitable quantity of water, glycerol and surfactant again, be prepared into astringent.
Beneficial effect of the present invention is illustrated below by way of test example.
Test example 1 present composition is on the impact of tryrosinase
Tryrosinase is a kind of polyphenol oxidase, is the key enzyme in dermal melanin forming process, rate-limiting enzyme, and activity and the B16 cell amount of tryrosinase are proportionate, and its activity change can cause dyschromicum dermatosis.Tyrosinase inhibitor is active by restraint of tyrosinase, stops melanin to be formed, can be used to the diseases such as prevention and therapy pigmentation, chloasma, have broad application prospects at cosmetics and field of medicaments.
1. material
TYR solution (0.5mg/ml), tryrosinase (100U/ml)
The present composition 1: get Pseudobulbus Bletillae (Rhizoma Bletillae) 58g, Cortex Mori 15g, Radix Pseudostellariae 17g, Periostracum Cicadae 11g, Radix Arnebiae (Radix Lithospermi) 11g, pulverizes, after mixing, decoct with water 3 times, each 1.5h, merging filtrate, concentrated, gained extractum after dry, then be diluted with water to concentration 10%w/w(with crude drug gauge) solution.
The present composition 2: get Pseudobulbus Bletillae (Rhizoma Bletillae) 45g, Cortex Mori 21g, Radix Pseudostellariae 21g, Periostracum Cicadae 15g, Radix Arnebiae (Radix Lithospermi) 15g, pulverizes, after mixing, decoct with water 3 times, each 1.5h, merging filtrate, concentrated, gained extractum after dry, then be diluted with water to concentration 10%w/w(with crude drug gauge) solution.
The present composition 3: get Pseudobulbus Bletillae (Rhizoma Bletillae) 49g, Cortex Mori 24g, Radix Pseudostellariae 35g, Periostracum Cicadae 23g, Radix Arnebiae (Radix Lithospermi) 23g, pulverizes, after mixing, decoct with water 3 times, each 1.5h, merging filtrate, concentrated, gained extractum after dry, then be diluted with water to concentration 10%w/w(with crude drug gauge) solution.
2, test method
The inhibit activities (appointing clear, Yu Xiaoyan etc., enzyme microb whitening anti-aging efficacy study, fragrance flavor and cosmetic, 3 phases in 2008) of the present composition 1,2 pairs of tryrosinases is measured according to literature method
3, result of the test
Table 1 present composition is to the inhibit activities of tryrosinase
| Tested material | Tyrosinase inhibition rate (%) |
| The present composition 1 | 97.53 |
| The present composition 2 | 93.22 |
| The present composition 3 | 86.41 |
| Blank | 0 |
From above-mentioned result of the test, the present composition has good tyrosinase inhibitory activity, illustrates that the present composition can stop melanin to be formed, can be used for the diseases such as prevention and therapy pigmentation, chloasma.Wherein, better with the drug activity of compositions 1,2.
Test example 2 present composition is to the effect of human body skin
1, the mensuration of keratodermatitis moisture and moisture loss measure
Moisture is one of important moulding material of epiderm skin horny layer, and during skin aging, horny layer of epidermis becomes
Thin, in horny layer, natural moisture preserving component content reduces, and skin hydration ability declines, and moisture of skin is lost to be increased; Meanwhile, there is histological structure and morphological change and made skin engender fine wrinkles in cell shrinkage Telatrophy.By the degree of skin aging and effect of Moisturizer can be reflected to a certain extent to the mensuration of moisture of skin.
Experimental technique: select healthy skin, without the tested crowd of cosmetic allergic contact dermatitis history, age 20-35 year, wherein male 15, women 22.Room temperature 25 DEG C ± 1 DEG C; Humidity 50% ± 5%.Clean face during test, and everyone clean time is identical, selects Face and cheek 4cm × 4cm skin as test zone, facial film of applying ointment or plaster after skin dries.
Facial film group of the present invention, the facial film that embodiment of applying ointment or plaster 1 is made; Matched group is applied ointment or plaster not containing the substrate facial film of Chinese medicine extract, and its substrate is identical with the embodiment of the present invention 1 facial film.
Measure: at Face and cheek (4cm × 4cm) test zone, after product to be used, 10min tests.
1) water content of Face and cheek skin is measured with digital skin moisture detector.Use after corresponding product after 1h, 2h, 4h, 6h, survey Face and cheek moisture content of skin, measure and average for three times.
2) water loss amount of Face and cheek skin is measured with percutaneous moisture loss measuring instrument.Use after corresponding product after 1h, 2h, 4h, 6h, survey Face and cheek moisture of skin windage, measure and average for three times.
Experimental result:
The change of keratodermatitis capacitance before and after product is used to weigh the change of water content of stratum corneum thus evaluate the moisture-keeping efficacy of cosmetics by test.The method carries out quantification to skin keratin moisture, can react the change of skin moisture content delicately, and favorable reproducibility, be one of method that current moisture-keeping cosmetics efficacy assessments is conventional.The impact of this product on skin moisture content is as shown in table 2.
Table 2 moisture test value
Note: compare p < 0.05 with matched group
As can be seen from Table 2, facial film group of the present invention moistening effect after use 1h is the most remarkable, and moistening effect is long.
Moisture of skin windage reflects pilot region moisture loss Changing Pattern in time in test period, it represent the lock water function of cosmetics.Its value is less, and moisture loss is fewer, and lock water effect is stronger.The impact that facial film of the present invention scatters and disappears on moisture of skin is as shown in table 3.
Table 3 moisture loss test value
Note: compare p < 0.05 with matched group
As shown in Table 3, after using facial film of the present invention, moisture of skin windage obviously declines.Comparing with matched group, all there is significant difference at 2-6h in facial film group of the present invention, illustrates that facial film of the present invention has the lasting lock water effect keeping moisture.
Test example 3 skin elasticity is tested
Skin elasticity year skin aging and reducing, therefore skin elasticity is one of important symbol judging skin aging, is the requisite project of efficacy detection of anti-aging cosmetics.
Experimental technique: select healthy, skin normal, without the tested crowd of cosmetic allergic contact dermatitis history, age 20-35 year, wherein male 8, women 30.Within one week, be a course for the treatment of, totally four courses for the treatment of, by facial cleansing at every turn before applying ointment or plaster, and at every turn clean time identical, corresponding product of applying ointment or plaster after skin dries, each group to be applied ointment or plaster corresponding product 1 time every day, and each one pastes.
Facial film group of the present invention, the facial film made in embodiment of applying ointment or plaster 1, matched group is applied ointment or plaster not containing the substrate facial film of Chinese medicine extract.
Measure: select Face and cheek as test zone, test after product 10min to be used.Use skin elasticity tester to measure skin elasticity curve, according to amount of tension and the resilience data of skin, can assess the moisturizing of cosmetics and anti-senescence function.
Experimental result:
Skin elasticity test is based on suction and stretching principle, a negative pressure is produced on the surface of tested skin, by in skin inspiration special test probe, skin is inhaled into the degree of depth and is recorded by a non-contact optical detection system, measurement result represents with an index usually, unit is 1, and numerical value is larger, illustrates that skin elasticity is stronger.The impact of facial film of the present invention on skin elasticity is as shown in table 4.
Table 4 skin elasticity test value
Note: compare p < 0.05 with matched group
As can be seen from Table 4, facial film group buccal place of the present invention elasticity number raises gradually, uses facial film of the present invention 2 weeks rear skin elasticity values to significantly improve.Compare with matched group, facial film of the present invention obviously can strengthen skin elasticity, illustrates that facial film of the present invention has enhancing skin elasticity, the function of the wrinkle removing that compacts.
In sum, the present composition, good to the inhibit activities of tryrosinase, moisture-keeping function is strong, and the persistent period is long, effectively can strengthen skin elasticity, meanwhile, said composition uses monarch theory for instructing each Chinese crude drug reasonable compatibility, has played synergistic function, having more significant check melanin generates active, provide a kind of have eliminate mottle, compact new skin care item that are crease-resistant, moisturizing whitening.
Claims (8)
1. a whitening skin and preserving moisture anti-apolexis composition, is characterized in that: it is the external preparation be prepared from by the crude drug of following weight proportion:
Pseudobulbus Bletillae (Rhizoma Bletillae) 20-60 part, Cortex Mori 15-35 part, Radix Pseudostellariae 17-47 part, Periostracum Cicadae 10-37 part, Radix Arnebiae (Radix Lithospermi) 10-37 part.
2. whitening skin and preserving moisture anti-apolexis composition according to claim 1, is characterized in that: it is the external preparation be prepared from by the crude drug of following weight proportion:
Pseudobulbus Bletillae (Rhizoma Bletillae) 45-58 part, Cortex Mori 15-24 part, Radix Pseudostellariae 17-35 part, Periostracum Cicadae 11-23 part, Radix Arnebiae (Radix Lithospermi) 11-23 part.
3. whitening skin and preserving moisture anti-apolexis composition according to claim 1 and 2, it is characterized in that: described compositions be with the water of each crude drug or/and ethanol extraction is for active component, add the adjuvant that pharmacy or cosmetics are commonly used or Supplementary active ingredients preparation and come preparation for external application to skin.
4. whitening skin and preserving moisture anti-apolexis composition according to claim 3, is characterized in that: described concentration of alcohol is 50-80%v/v.
5. whitening skin and preserving moisture anti-apolexis composition according to claim 3, is characterized in that: described complementary composition is collagen protein, hyaluronic acid sodium or vitamin.
6. according to claim 1 ?whitening skin and preserving moisture anti-apolexis composition described in 5 any one, it is characterized in that: described external preparation is facial film, protective skin cream, emulsion, gel or astringent.
7. claim 1 ?compositions described in 6 any one preparing the purposes in tyrosinase inhibitor.
8. claim 1 ?compositions described in 6 any one preparing antiplaque, moisturizing, the crease-resistant or purposes that improves in the external use skin care of skin elasticity or medicine.
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| CN201410069356.0A CN104825804B (en) | 2014-02-07 | 2014-02-27 | A kind of skin whitening, moisturizing anti-apolexis composition and its production and use |
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| CN201410069356.0A CN104825804B (en) | 2014-02-07 | 2014-02-27 | A kind of skin whitening, moisturizing anti-apolexis composition and its production and use |
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| CN107308440A (en) * | 2017-06-01 | 2017-11-03 | 李博 | Dispel striae of pregnancy, scar reparation, anti-wrinkle Skin whitening care cosmeticses and preparation method thereof |
| CN107440950A (en) * | 2016-05-30 | 2017-12-08 | 上海家化联合股份有限公司 | Radix Arnebiae extract and its preparation and application |
| CN110755341A (en) * | 2019-10-08 | 2020-02-07 | 甘肃锦东健康科技有限公司 | Anti-aging medical biological repair film containing traditional Chinese medicines and preparation method thereof |
| CN115381757A (en) * | 2022-09-26 | 2022-11-25 | 湖南省皇媛世家生命科技有限公司 | Formula and preparation method of spot-lightening anti-aging cream |
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Cited By (4)
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| CN107440950A (en) * | 2016-05-30 | 2017-12-08 | 上海家化联合股份有限公司 | Radix Arnebiae extract and its preparation and application |
| CN107308440A (en) * | 2017-06-01 | 2017-11-03 | 李博 | Dispel striae of pregnancy, scar reparation, anti-wrinkle Skin whitening care cosmeticses and preparation method thereof |
| CN110755341A (en) * | 2019-10-08 | 2020-02-07 | 甘肃锦东健康科技有限公司 | Anti-aging medical biological repair film containing traditional Chinese medicines and preparation method thereof |
| CN115381757A (en) * | 2022-09-26 | 2022-11-25 | 湖南省皇媛世家生命科技有限公司 | Formula and preparation method of spot-lightening anti-aging cream |
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| CN104825804B (en) | 2018-03-30 |
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