CN110960437A - Dandruff-removing hair washing bubbles and preparation method thereof - Google Patents

Abstract

The invention belongs to the field of daily necessities, and particularly relates to anti-dandruff shampoo bubbles and a preparation method thereof. The dandruff removing shampoo bubble comprises 5-15 parts of chelating agent, 40-65 parts of amino acid surfactant, 20-30 parts of nonionic surfactant, 5-20 parts of amphoteric surfactant, 1-10 parts of conditioner, 2-10 parts of dandruff removing agent, 2-8 parts of citric acid, 5-15 parts of lutein, 1-2 parts of soybean protein, 1-15 parts of essence, 0.1-1 part of preservative and 60-85 parts of water. The shampoo bubble has no obvious consistency, the shampoo bubble can be pumped by a bubble pump head, the material body is weakly acidic, the pumped bubble is closer to the scalp, the hair follicle is further touched, scalp grease is cleaned, the scalp environment is improved, and meanwhile, the shampoo bubble contains a plant anti-dandruff agent and can well achieve the anti-dandruff effect when being matched with piroctone olamine. In addition, the shampoo bubbles can be prepared at normal temperature without heating, the production process is simple, energy and time are saved, and the production cost is saved.

Description

Dandruff-removing hair washing bubbles and preparation method thereof

Technical Field

The invention belongs to the field of daily necessities, and particularly relates to anti-dandruff shampoo bubbles and a preparation method thereof.

Background

With the continuous improvement of living standard of people, people almost use the shampoo to clean hair every day, the shampoo in the current market is various in types and different in functions, and a client can select the shampoo suitable for the client according to the requirement of the client on the hair quality.

Due to the fact that environmental problems are becoming more serious in recent years, people are exposed to unclean air for a long time, dust on the scalp is increased, and therefore the scalp is stimulated to secrete a large amount of grease, scalp cells are damaged, stratum corneum scales generated on the surface layer of the scalp are increased to fall off, and a large amount of dandruff is generated. According to incomplete statistics, 59 percent of women and 63 percent of men in China are always troubled by dandruff, and for a dandruff vexation family, the selection of a correct anti-dandruff shampoo is particularly important.

Most of the traditional products are composed of common surfactants, bactericides, conditioners, emulsified silicone oil, pearling agents, essence and the like. If the common surfactant is not properly selected and used in an excessive amount, the scalp can be excessively degreased, so that itching, dandruff, hair damage and hair loss can be caused, and alopecia can be seriously caused. When the shampoo containing the emulsified silicone oil is used for a long time, the problems of thick and heavy hair, greasiness, loss of elasticity, even blockage of hair follicles, incapability of normal metabolism and the like caused by excessive accumulation of the silicone oil on the surface of the hair are solved. Most of the existing shampoo without silicone oil has poor dandruff removing effect and has the problems of itchy scalp after use and the like.

Patent document No. CN101690697B discloses an anti-dandruff shampoo composition, which mainly comprises several components such as surfactant, unsaturated fatty alcohol ester, anti-dandruff agent, etc., wherein the surfactant is one or a combination of anionic surfactant and amphoteric surfactant, and the unsaturated fatty alcohol ester is selected from unsaturated fatty alcohol ester with more than one unsaturated bond and linear or branched chain having 8-40 carbon atoms. The antidandruff agent is a combination of a non-hydrophilic particulate antidandruff agent and a hexamidine derivative. The anti-dandruff shampoo composition provided by the invention can really achieve a certain anti-dandruff effect, but has fewer bubbles and poor bubble stability in the using process, and can not thoroughly clean dirty objects on the scalp.

In conclusion, the defects of poor dandruff removing effect, easy occurrence of side effect of scalp itching after use, poor stability, unclean cleaning and the like generally exist in the prior art.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention aims to provide an anti-dandruff shampoo bubble and a preparation method thereof. The dandruff removing bubble provided by the invention can directly pump the shampoo bubbles by adopting the bubble pump head, the pumped bubbles can be closer to the scalp, scalp grease is cleaned, and meanwhile, the plant dandruff removing agent in the bubbles can effectively remove dandruff and improve the scalp environment.

In order to achieve the purpose, the technical scheme of the invention is as follows:

an anti-dandruff shampoo bubble comprises the following components in parts by weight:

5-15 parts of chelating agent, 40-65 parts of amino acid surfactant, 20-30 parts of nonionic surfactant, 5-20 parts of amphoteric surfactant, 1-10 parts of conditioner, 2-10 parts of anti-dandruff agent, 2-8 parts of citric acid, 5-15 parts of lutein, 1-2 parts of soybean protein, 1-15 parts of essence, 0.1-1 part of preservative and 60-85 parts of water.

Further, the anti-dandruff shampoo bubbles comprise the following components in parts by weight: 12.5 parts of chelating agent, 53.4 parts of amino acid surfactant, 25 parts of nonionic surfactant, 13.8 parts of amphoteric surfactant, 6 parts of conditioner, 6.8 parts of anti-dandruff agent, 5.9 parts of citric acid, 11.5 parts of lutein, 1.5 parts of soybean protein, 10 parts of essence, 0.8 part of preservative and 76 parts of water.

Further, the chelating agent in the anti-dandruff shampoo bubbles is EDTA-2 Na.

Furthermore, the amino acid surfactant in the anti-dandruff shampoo bubbles is composed of sodium cocoyl glutamate, sodium cocoyl amido propionate and sodium methyl cocoyl taurate according to the mass ratio of 1-5:1-4: 1-5.

Further, the nonionic surfactant in the anti-dandruff shampoo bubbles is PEG-80 sorbitan laurate.

Further, the amphoteric surfactant in the anti-dandruff shampoo bubbles is composed of lecithin, alkylamide phosphoric betaine and N-alkylthio- β -aminopropionic acid according to the mass ratio of 1-3:2-5: 1-4.

Further, the conditioner in the anti-dandruff shampoo bubbles is one or more of polyquaternium-7, PPG-3 octyl ether and PPG-3 benzyl ether myristate.

Furthermore, the anti-dandruff agent in the anti-dandruff shampoo bubbles is prepared from piroctone olamine salt, paeonol and dipotassium glycyrrhizinate according to the mass ratio of 1-3:2-4: 1-2.

Further, the preservative is composed of sodium benzoate and phenoxyethanol according to the weight ratio of 3: 5.

Meanwhile, the invention also provides a preparation method of the dandruff removing shampoo bubbles, which comprises the following specific steps:

s1, dissolving the chelating agent in water, stirring uniformly, then respectively adding the amino acid surfactant, the nonionic surfactant and the amphoteric surfactant with the formula ratio, and stirring at the rotating speed of 400-600rpm for 20-30min until the solution is colorless and transparent to obtain a mixed solution A;

s2, respectively slowly adding a conditioner, a scurf remover and citric acid into the mixed solution A prepared in the step S1, stirring at the rotating speed of 400-600rpm for 20-30min until the mixture is completely dissolved, and homogenizing for half an hour to prepare a mixed solution B;

s3, adding the essence and the preservative into the mixed solution B prepared in the step S2, and stirring for 15-25min at the rotating speed of 600-800rpm until the solution is colorless and transparent, thus obtaining the liquid.

The amino acid surfactant and the nonionic surfactant are added to play a good role in foaming, the amphoteric surfactant reduces the irritation of the anionic surfactant and can improve the stability of the bubbles, wherein lecithin is a natural amphoteric surfactant and has good hydrophilicity and lipophilicity, and is an indispensable substance for each cell of a human body, inositol in lecithin is a main nutrient substance of hair and can inhibit hair loss and slowly blacken white hair.

Compared with the prior art, the anti-dandruff shampoo bubble provided by the invention has the following advantages:

1. the anti-dandruff shampoo bubbles provided by the invention have no obvious consistency, and the shampoo bubbles can be pumped by a bubble pump head, so that the use is more convenient;

2. the dandruff removing shampoo bubbles provided by the invention are weakly acidic, and the pumped bubbles are closer to the scalp, so that the dandruff removing shampoo bubbles can further touch the hair follicles, clean scalp grease and improve the scalp environment;

3. the anti-dandruff shampoo bubble provided by the invention contains the plant anti-dandruff agent, and can well achieve the anti-dandruff effect when being matched with the piroctone olamine salt;

4. the anti-dandruff shampoo bubble provided by the invention contains lutein and soy protein, can prevent scalp and hair from being oxidized, and enables the hair to be smoother;

5. the anti-dandruff shampoo bubbles provided by the invention can be prepared at normal temperature, heating is not needed, the production process is simple, energy and time are saved, and the production cost is saved.

Detailed Description

The present invention will be further described below by way of specific embodiments, but the present invention is not limited to only the following examples. Various modifications can be made by those skilled in the art based on the basic idea of the invention, but it is within the scope of the invention as long as it does not depart from the basic idea of the invention.

Example 1 an anti-dandruff shampoo bubble

An anti-dandruff shampoo bubble comprises the following components in parts by weight:

12.5 parts of EDTA-2Na, 53.4 parts of amino acid surfactant, 25 parts of PEG-80 sorbitan laurate, 13.8 parts of amphoteric surfactant, 76 parts of polyquaternary ammonium salt, 6.8 parts of anti-dandruff agent, 5.9 parts of citric acid, 11.5 parts of lutein, 1.5 parts of soybean protein, 10 parts of essence, 0.8 part of preservative and 76 parts of water, wherein the amino acid surfactant comprises sodium cocoyl glutamate, sodium cocoyl amido propionate and sodium methyl cocoyl taurate in a mass ratio of 1:3:1, the amphoteric surfactant comprises lecithin, alkyl amidophosphoric acid betaine and N-alkylthio- β -aminopropionic acid in a mass ratio of 1:2:1, the anti-dandruff agent comprises piroctone ethanolamine salt, paeonol and dipotassium glycyrrhizinate in a mass ratio of 1:3:1, and the preservative comprises benzene and phenoxyethanol in a weight ratio of 3: 5.

Meanwhile, the invention also provides a preparation method of the dandruff removing shampoo bubbles, which comprises the following specific steps:

s1, dissolving EDTA-2Na in water, uniformly stirring, respectively adding the amino acid surfactant, PEG-80 sorbitan laurate and the amphoteric surfactant according to the formula ratio, and stirring at 400 rpm until the solution is colorless and transparent to obtain a mixed solution A;

s2, slowly adding the polyquaternium-7, the anti-dandruff agent and the citric acid into the mixed liquid A prepared in the step S1 respectively, stirring at 400 rpm until the polyquaternium-7, the anti-dandruff agent and the citric acid are completely dissolved, and homogenizing for half an hour to prepare mixed liquid B;

s3, adding essence and preservative into the mixed liquid B prepared in the step S2, and stirring at 600 revolutions per minute until the solution is colorless and transparent.

Example 2 an anti-dandruff shampoo bubble

An anti-dandruff shampoo bubble comprises, by weight, 7 parts of EDTA-2Na, 45 parts of an amino acid surfactant, 22 parts of PEG-80 sorbitan laurate, 10 parts of an amphoteric surfactant, 3 parts of PPG-3 octyl ether, 4 parts of an anti-dandruff agent, 3 parts of citric acid, 7 parts of lutein, 1.2 parts of soybean protein, 4 parts of essence, 0.3 part of a preservative and 65 parts of water, wherein the amino acid surfactant comprises sodium cocoyl glutamate, sodium cocoyl amido propionate and sodium methyl cocoyl taurate in a mass ratio of 1:2:1, the amphoteric surfactant comprises lecithin, alkyl amidophosphoric acid betaine and N-alkyl thio- β -aminopropionic acid in a mass ratio of 2:2:1, the anti-dandruff agent comprises piroctone ethanolamine, paeonol and dipotassium glycyrrhizinate in a mass ratio of 1:1:2, and the preservative comprises sodium benzoate and ethanol in a weight ratio of 3: 5.

Meanwhile, the invention also provides a preparation method of the dandruff removing shampoo bubbles, which comprises the following specific steps:

s1, dissolving EDTA-2Na in water, uniformly stirring, respectively adding the amino acid surfactant, PEG-80 sorbitan laurate and the amphoteric surfactant according to the formula ratio, and stirring at 450 rpm until the solution is colorless and transparent to obtain a mixed solution A;

s2, respectively slowly adding PPG-3 octyl ether, an anti-dandruff agent and citric acid into the mixed solution A prepared in the step S1, stirring at 400 revolutions per minute until the PPG-3 octyl ether, the anti-dandruff agent and the citric acid are completely dissolved, and homogenizing for half an hour to prepare a mixed solution B;

s3, adding essence and preservative into the mixed liquid B prepared in the step S2, and stirring at 600 revolutions per minute until the solution is colorless and transparent.

Example 3 an anti-dandruff shampoo bubble

An anti-dandruff shampoo bubble comprises the following components in parts by weight:

the anti-dandruff shampoo comprises the following components, by weight, 9 parts of EDTA-2Na, 50 parts of amino acid surfactant, 24 parts of PEG-80 sorbitan laurate, 15 parts of amphoteric surfactant, 5 parts of PPG-3 benzyl ether myristate, 6 parts of anti-dandruff agent, 4 parts of citric acid, 9 parts of lutein, 1.4 parts of soybean protein, 8 parts of essence, 0.5 part of preservative and 70 parts of water, wherein the amino acid surfactant comprises sodium cocoyl glutamate, sodium cocoyl amido propionate and sodium methyl cocoyl taurate in a mass ratio of 2:1:1, the amphoteric surfactant comprises lecithin, alkyl amidophosphoric acid betaine and N-alkyl sulfo- β -aminopropionic acid in a mass ratio of 1:2:3, the anti-dandruff agent comprises piroctone olamine, paeonol and dipotassium glycyrrhizinate in a mass ratio of 1:2:1, and the preservative comprises sodium benzoate and phenoxyethanol in a weight ratio of 3: 5.

Meanwhile, the invention also provides a preparation method of the dandruff removing shampoo bubbles, which comprises the following specific steps:

s1, dissolving EDTA-2Na in water, uniformly stirring, respectively adding the amino acid surfactant, PEG-80 sorbitan laurate and the amphoteric surfactant according to the formula ratio, and stirring at 400 rpm until the solution is colorless and transparent to obtain a mixed solution A;

s2, respectively slowly adding PPG-3 benzyl ether myristate, an antidandruff agent and citric acid into the mixed solution A prepared in the step S1, stirring at 450 rpm until the mixture is completely dissolved, and homogenizing for half an hour to prepare a mixed solution B;

s3, adding essence and preservative into the mixed liquid B prepared in the step S2, and stirring at 600 revolutions per minute until the solution is colorless and transparent.

Example 4 an anti-dandruff shampoo bubble

An anti-dandruff shampoo bubble comprises the following components in parts by weight:

12.5 parts of EDTA-2Na, 53.4 parts of amino acid surfactant, 25 parts of PEG-80 sorbitan laurate, 13.8 parts of amphoteric surfactant, 6 parts of conditioner, 6.8 parts of anti-dandruff agent, 5.9 parts of citric acid, 11.5 parts of lutein, 1.5 parts of soybean protein, 10 parts of essence, 0.8 part of preservative and 76 parts of water, wherein the amino acid surfactant in the anti-dandruff shampoo bubble comprises sodium cocoyl glutamate, sodium cocoyl amidopropionate and sodium methyl cocoyl taurate in a weight ratio of 1:2:3, the amphoteric surfactant in the anti-dandruff bubble comprises lecithin, alkyl amidophosphoric acid betaine and N-alkylthio- β -aminopropionic acid in a weight ratio of 2:3:1, the conditioner in the anti-shampoo bubble comprises polyquaternium-7 and PPG-3 octyl ether in a weight ratio of 1:1, the anti-shampoo bubble comprises pyridone, sodium diketonate and disodium phenoxyethanol in a weight ratio of 4: 4, and the preservative comprises phenoxyphenylethyl acid, and phenoxyethanol in a weight ratio of 1:3: 1.

Meanwhile, the invention also provides a preparation method of the dandruff removing shampoo bubbles, which comprises the following specific steps:

s1, dissolving EDTA-2Na in water, uniformly stirring, respectively adding the amino acid surfactant, PEG-80 sorbitan laurate and the amphoteric surfactant according to the formula ratio, and stirring at 400 rpm until the solution is colorless and transparent to obtain a mixed solution A;

s2, respectively slowly adding a conditioner, an anti-dandruff agent and citric acid into the mixed solution A prepared in the step S1, stirring at 500 revolutions per minute until the mixture is completely dissolved, and homogenizing for half an hour to prepare a mixed solution B;

s3, adding essence and preservative into the mixed liquid B prepared in the step S2, and stirring at 650 rpm until the solution is colorless and transparent.

Example 5 an anti-dandruff shampoo bubble

An anti-dandruff shampoo bubble comprises the following components in parts by weight:

the anti-dandruff shampoo comprises the following components, by weight, EDTA-2Na13 parts, 60 parts of an amino acid surfactant, 28 parts of PEG-80 sorbitan laurate, 17 parts of an amphoteric surfactant, 8 parts of a conditioner, 8 parts of an anti-dandruff agent, 7 parts of citric acid, 13 parts of lutein, 1.6 parts of soybean protein, 12 parts of essence, 0.7 part of a preservative and 80 parts of water, wherein the amino acid surfactant in the anti-dandruff shampoo bubbles comprises sodium cocoyl glutamate, sodium cocoyl amido propionate and sodium methyl cocoyl taurate in a weight ratio of 3:1:2, the amphoteric surfactant in the anti-dandruff shampoo bubbles comprises lecithin, alkyl amidophosphoric betaine and N-alkylthio- β -aminopropionic acid in a weight ratio of 3:2:1, the conditioner in the anti-dandruff shampoo bubbles comprises polyquaternium-7 and PPG-3 benzyl ether myristate in a weight ratio of 1:1, and the anti-dandruff agent in the anti-dandruff shampoo bubbles comprises piroctone olamine, paeonol, dipotassium diphenoxylate and benzene benzoate in a weight ratio of 3: 1.

Meanwhile, the invention also provides a preparation method of the dandruff removing shampoo bubbles, which comprises the following specific steps:

s1, dissolving EDTA-2Na in water, uniformly stirring, respectively adding the amino acid surfactant, PEG-80 sorbitan laurate and the amphoteric surfactant according to the formula ratio, and stirring at 500 rpm until the solution is colorless and transparent to obtain a mixed solution A;

s2, respectively slowly adding a conditioner, an anti-dandruff agent and citric acid into the mixed solution A prepared in the step S1, stirring at 400 rpm until the mixture is completely dissolved, and homogenizing for half an hour to prepare a mixed solution B;

s3, adding essence and preservative into the mixed liquid B prepared in the step S2, and stirring at 650 rpm until the solution is colorless and transparent.

Example 6 an anti-dandruff shampoo bubble

An anti-dandruff shampoo bubble comprises the following components in parts by weight:

the anti-dandruff shampoo bubble comprises EDTA-2Na15, an amino acid surfactant 65, PEG-80 sorbitan laurate 30, an amphoteric surfactant 20, a conditioner 10, an anti-dandruff agent 10, citric acid 8, lutein 15, soybean protein 2, essence 15, a preservative 1 and water 85, wherein the amino acid surfactant in the anti-dandruff shampoo bubble comprises sodium cocoyl glutamate, sodium cocoamido propionate and sodium methyl cocoacyl taurate in a weight ratio of 3:2:1, the amphoteric surfactant in the anti-dandruff shampoo bubble comprises lecithin, alkylamide phosphoric acid betaine and N-alkylthio- β -aminopropionic acid in a weight ratio of 2:3:4, the conditioner in the anti-dandruff shampoo bubble comprises polyquaternium-7 and PPG-3 octyl ether in a weight ratio of 2:1, and the anti-dandruff agent in the anti-dandruff bubble comprises piroctone olamine, glycyrrhizic acid, potassium paeonol and dipotassium diphenoxybenzoate in a weight ratio of 3:1, and the preservative comprises sodium benzoate and benzene.

Meanwhile, the invention also provides a preparation method of the dandruff removing shampoo bubbles, which comprises the following specific steps:

s1, dissolving EDTA-2Na in water, uniformly stirring, respectively adding the amino acid surfactant, PEG-80 sorbitan laurate and the amphoteric surfactant according to the formula ratio, and stirring at 500 rpm until the solution is colorless and transparent to obtain a mixed solution A;

s2, respectively slowly adding a conditioner, an anti-dandruff agent and citric acid into the mixed solution A prepared in the step S1, stirring at 450 revolutions per minute until the mixture is completely dissolved, and homogenizing for half an hour to prepare a mixed solution B;

s3, adding essence and preservative into the mixed liquid B prepared in the step S2, and stirring at 700 rpm until the solution is colorless and transparent.

Comparative example 1 an anti-dandruff shampoo bubble

An anti-dandruff shampoo bubble comprises the following components in parts by weight:

12.5 parts of EDTA-2Na12, 53.4 parts of amino acid surfactant, 25 parts of PEG-80 sorbitan laurate, 13.8 parts of amphoteric surfactant, 6 parts of conditioner, 6.8 parts of anti-dandruff agent, 5.9 parts of citric acid, 11.5 parts of lutein, 1.5 parts of soybean protein, 10 parts of essence, 0.8 part of preservative and 76 parts of water, wherein the amino acid surfactant in the anti-dandruff shampoo bubble comprises sodium cocoyl glutamate, sodium cocoyl amidopropionate and sodium methyl cocoyl taurate in a weight ratio of 1:2:3, the amphoteric surfactant in the anti-dandruff bubble comprises lecithin, alkyl amidophosphoric acid betaine and N-alkylthio- β -aminopropionic acid in a weight ratio of 2:3:1, the conditioner in the anti-shampoo bubble comprises polyquaternium-7 and PPG-3 octyl ether in a weight ratio of 1:1, the anti-shampoo bubble comprises ammonium salt of piroctone, sodium benzoate in a weight ratio of 2:4, and the preservative comprises 5: 3: 1.

The anti-dandruff shampoo bubbles were prepared in a similar manner to example 4.

The difference between this comparative example and example 4 is that the antidandruff agent in this comparative example does not have dipotassium glycyrrhizinate added.

Comparative example 2 an anti-dandruff shampoo bubble

An anti-dandruff shampoo bubble comprises the following components in parts by weight:

12.5 parts of EDTA-2Na, 53.4 parts of amino acid surfactant, 25 parts of PEG-80 sorbitan laurate, 13.8 parts of amphoteric surfactant, 6 parts of conditioner, 6.8 parts of anti-dandruff agent, 5.9 parts of citric acid, 11.5 parts of lutein, 1.5 parts of soybean protein, 10 parts of essence, 0.8 part of preservative and 76 parts of water; the amino acid surfactant in the dandruff removing shampoo bubbles consists of sodium cocoyl glutamate, sodium cocoyl amido propionate and sodium methyl cocoyl taurate according to the weight ratio of 1:2: 3; the amphoteric surfactant in the anti-dandruff shampoo bubbles consists of lecithin and alkyl amide phosphoric betaine according to the weight ratio of 2: 3; the conditioner in the anti-dandruff shampoo bubbles consists of polyquaternium-7 and PPG-3 octyl ether according to the weight ratio of 1: 1; the anti-dandruff agent in the anti-dandruff shampoo bubbles is composed of piroctone olamine, paeonol and dipotassium glycyrrhizinate according to the weight ratio of 2:4: 1; the preservative is composed of sodium benzoate and phenoxyethanol according to the weight ratio of 3: 5.

The anti-dandruff shampoo bubbles were prepared in a similar manner to example 4.

This comparative example differs from example 4 in that the amphoteric surfactant in this comparative example does not have the addition of N-alkylthio- β -aminopropionic acid.

Comparative example 3 an anti-dandruff shampoo bubble

An anti-dandruff shampoo bubble comprises the following components in parts by weight:

12.5 parts of EDTA-2Na, 53.4 parts of amino acid surfactant, 25 parts of PEG-80 sorbitan laurate, 13.8 parts of amphoteric surfactant, 6 parts of conditioner, 6.8 parts of anti-dandruff agent, 5.9 parts of citric acid, 11.5 parts of lutein, 1.5 parts of soybean protein, 10 parts of essence, 0.8 part of preservative and 76 parts of water, wherein the amino acid surfactant in the anti-dandruff shampoo bubbles comprises sodium cocoyl glutamate and sodium cocoyl amido propionate in a weight ratio of 2:1, the amphoteric surfactant in the anti-dandruff shampoo bubbles comprises lecithin, alkyl amido phosphoric acid betaine and N-alkyl sulfo- β -aminopropionic acid in a weight ratio of 2:3:1, the conditioner in the anti-dandruff shampoo bubbles comprises polyquaternium ammonium salt-7 and PPG-3 octyl ether in a weight ratio of 1:1, and the anti-dandruff agent in the anti-dandruff shampoo bubbles comprises piroctone olamine, paeonol, dipotassium diphenoxylate and sodium benzoate in a weight ratio of 4: 1:3, and the preservative comprises 5: 3.

The anti-dandruff shampoo bubbles were prepared in a similar manner to example 4.

The difference between this comparative example and example 4 is that sodium methylcocoyltaurate in the amino acid surfactant in this comparative example is replaced by sodium cocoylglutamate.

Comparative example 4 an anti-dandruff shampoo bubble

An anti-dandruff shampoo bubble comprises the following components in parts by weight:

12.5 parts of EDTA-2Na, 53.4 parts of anionic surfactant, 25 parts of PEG-80 sorbitan laurate, 13.8 parts of amphoteric surfactant, 6 parts of conditioner, 6.8 parts of anti-dandruff agent, 5.9 parts of citric acid, 11.5 parts of lutein, 1.5 parts of soybean protein, 10 parts of essence, 0.8 part of preservative and 76 parts of water, wherein the anionic surfactant in the anti-dandruff shampoo bubble is sodium laureth sulfate, the amphoteric surfactant in the anti-dandruff shampoo bubble comprises lecithin, alkylamide phosphobetaine and N-alkylthio- β -aminopropionic acid in a weight ratio of 2:3:1, the conditioner in the anti-dandruff shampoo bubble comprises polyquaternium-7 and PPG-3 octyl ether in a weight ratio of 1:1, and the anti-dandruff agent in the anti-dandruff bubble comprises piroctone olamine, paeonol and dipotassium glycyrrhizinate in a weight ratio of 2:4:1, and the preservative comprises sodium benzoate and phenoxyaniline in a weight ratio of 3: 5.

The anti-dandruff shampoo bubbles were prepared in a similar manner to example 4.

The comparative example differs from example 4 in that the amino acid surfactant in the comparative example is replaced with an anionic surfactant.

Test example 1 flow Property test

Test samples: the anti-dandruff shampoo bubbles prepared in examples 1-6, comparative example 2 and comparative example 4.

The test method comprises the following steps: the prepared sample was loaded into a bottle with a bubble pump head, simulating normal use, and the sample was observed as it was pumped out of the bubble pump head.

The test results are shown in Table 1.

Table 1 flowability test results

Group of	Pump out condition
		Example 1	Normal pump out
Example 2	Normal pump out
		Example 3	Normal pump out
Example 4	Normal pump out
		Example 5	Normal pump out
Example 6	Normal pump out
		Comparative example 2	Difficult discharge and certain consistency of the material body
Comparative example 4	Difficult discharge and certain consistency of the material body

As can be seen from Table 1, the anti-dandruff shampoo bubbles provided by the present invention have good fluidity and can be pumped out normally, comparative example 2 changes the formulation ratio of the amphoteric surfactant, and N-alkylthio- β -aminopropionic acid is not added, so the body has certain consistency and is difficult to pump out, and comparative example 4 uses the anionic surfactant sodium laureth sulfate instead of the amino acid surfactant, which is easy to thicken, and the amino acid surfactant is not easy to thicken, so the body prepared by comparative example 4 has certain consistency and is difficult to pump out.

Test example 2 safety test

(1) Acute skin test

Test samples: the anti-dandruff shampoo bubbles obtained in examples 1-6 and comparative examples 1-4.

The test method comprises the following steps: 40 healthy adult white rabbits were randomly divided into 10 groups of 4 rabbits each. The hair on two sides of the spine of the white rabbit to be tested is cut off 24 hours before the test, the epidermis is not damaged, and the hair removing range is 3cm multiplied by 3cm respectively. 0.5mL of the samples from the examples and controls were applied directly to the skin and then covered with two layers of gauze (2.5 cm. times.2.5 cm) and a layer of cellophane, secured with a non-irritating adhesive tape and bandage. The other side of the skin served as a control. The application time is 4h by adopting a sealing test. After the test was completed, the residual substances were removed with warm water. Skin reactions at the applied sites were observed at 1, 24, 48 and 72h after removal of the test substance, skin reaction scores were performed according to table 2, and skin irritation intensity was determined according to table 3 based on the highest integrated mean value at each observation time point of 24h, 48h and 72 h.

The test results are shown in Table 4.

TABLE 2 skin irritation response score

Table 3 mild grading of skin irritation

TABLE 4 acute skin test results

Group of	Total integral value	Intensity of stimulus
			Example 1	0.21	Has no irritation
Example 2	0.34	Has no irritation
			Example 3	0.26	Has no irritation
Example 4	0.15	Has no irritation
			Example 5	0.23	Has no irritation
Example 6	0.31	Has no irritation
			Comparative example 1	1.23	Light irritation
Comparative example 2	1.31	Light irritation
			Comparative example 3	0.45	Has no irritation
Comparative example 4	1.36	Light irritation

As can be seen from table 4, the anti-dandruff shampoo bubbles provided by the present invention are non-irritating and safe to use, especially, the total integral of example 4 of the present invention is only 0.15, and have little irritation to the skin, so example 4 is the best example of the present invention.comparative example 1 changes the formulation ratio of the anti-dandruff agent, does not add dipotassium glycyrrhizinate, and dipotassium glycyrrhizinate has good anti-inflammatory and antipruritic effects, so the anti-dandruff shampoo bubbles prepared by comparative example 1 have slight irritation, comparative example 2 changes the formulation ratio of the amphoteric surfactant, does not add N-alkylthio- β -aminopropionic acid, and the addition of N-alkylthio- β -aminopropionic acid can achieve good foaming and bactericidal functions, so comparative example 2 can reduce the antibacterial properties of the shampoo bubbles.comparative example 3 replaces sodium methylcocoyllotyl taurate with sodium cocoyl glutamate, both belong to amino acid surfactants, so the total integral does not change much, and the amino acid surfactant is replaced with anionic sodium laureth sulfate, and sodium laureth sulfate has a certain irritation, so the shampoo bubbles prepared by comparative example 4 have slight irritation.

(2) Acute eye test

Test samples: the anti-dandruff shampoo bubbles obtained in examples 1-6 and comparative examples 1-4.

The test method comprises the following steps: healthy adult white rabbits were selected at 30 and randomly divided into 10 groups of 3 rabbits each. The lower eyelid of the right eye of the white rabbit was gently pulled open, and 0.1mL (100mg) of the example and control samples were dropped into the conjunctival sac to allow the upper and lower eyelids to be passively closed for 1s to prevent the loss of the test substance. The left eye was not treated for self-control. Eyes were not rinsed within 24h after dropping the example sample. The eyes of the animals were examined at 1h, 24h, 48h, 72h, and 4d and 7d after dropping the example samples. If no stimulus response occurs for 72 hours, the test is terminated.

The test results are shown in Table 5.

TABLE 5 acute eye test results

Group of	Total integral value	Intensity of stimulus
			Example 1	0.25	Has no irritation
Example 2	0.37	Has no irritation
			Example 3	0.29	Has no irritation
Example 4	0.18	Has no irritation
			Example 5	0.31	Has no irritation
Example 6	0.43	Has no irritation
			Comparative example 1	1.45	Light irritation
Comparative example 2	1.49	Light irritation
			Comparative example 3	0.50	Has no irritation
Comparative example 4	1.56	Light irritation

As shown in Table 5, the anti-dandruff shampoo bubbles provided by the invention are non-irritating to eyes and can be safely used. Especially, the total integral in example 4 is only 0.18, so example 4 is the best embodiment of the present invention. In comparative examples 1, 2 and 4, the irritation of the shampoo bubbles to the eyes is increased due to the change of certain components; in contrast, in comparative example 3, since sodium methylcocoyltaurate was substituted with sodium cocoylglutamate, both of which are amino acid surfactants, no irritation to eyes was caused after the substitution.

Test example 3 anti-dandruff test

Test samples: the anti-dandruff shampoo bubbles obtained in examples 1-6 and comparative examples 1-4.

The test method comprises the following steps: at the beginning of the project in which the volunteers were recruited, the volunteers were assessed for dandruff by a dermatologist, wherein dandruff was graded as 5: 1: very slight; 2: slightly; 3: moderate; 4: severe; 5: very severe, 300 volunteers were recruited and all contained dandruff. Volunteers were randomly divided into 10 groups of 30 people each, who washed 3-4 times per week the shampoo bubbles of this example or comparative example (comparative example 2 and comparative example 4 used a common pump bottle, other examples and comparative example used a bubble pump bottle), for 4 weeks, and subjects were photographed and assessed for dandruff by a dermatologist for 2 times at weeks 0, 4 during the product period.

The results of the experiment are shown in Table 6.

TABLE 6 dandruff removal test

As can be seen from Table 6, the anti-dandruff shampoo bubbles provided by the invention have good anti-dandruff effect, and patients with severe dandruff can reduce the severity of dandruff to very slight after using the anti-dandruff shampoo bubbles provided by the invention for 4 weeks, wherein the anti-dandruff effect of example 4 is the best, and the score can be reduced by 3.60 after using the anti-dandruff shampoo bubbles provided by the invention for 4 weeks, so example 4 is the best example of the invention.A difference between comparative example 1 and example 4 is that dipotassium glycyrrhizinate is not added in the anti-dandruff agent, the anti-dandruff effect is obviously reduced, the addition of dipotassium glycyrrhizinate plays a certain role in anti-dandruff action or the combination of piroctone olamine and paeonol plays a good role in anti-dandruff action, comparative example 2, comparative example 3 and example 4 are respectively different in that N-alkylthio- β -aminopropionic acid is not added, the same amount of sodium cocoyl glutamate is used for replacing sodium methylcocoyl taurate, the anti-dandruff effect is reduced, the N-alkylthio- β -aminopropionic acid plays an important role in the formula components, can play a synergistic role with the anti-dandruff effect, the surface active ingredient is greatly reduced by the replacement of the amino acid, and the formula of the anti-dandruff active ingredient of the comparative example 4 is also demonstrated by the synergistic effect of the anti-dandruff formula.

The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Those skilled in the art will recognize that changes may be made to the embodiments described above without departing from the spirit and scope of the invention. Therefore, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the technical spirit of the present invention are covered by the claims of the present invention.

Claims (9)

1. The anti-dandruff shampoo bubble is characterized by comprising the following components in parts by weight:

5-15 parts of chelating agent, 40-65 parts of amino acid surfactant, 20-30 parts of nonionic surfactant, 5-20 parts of amphoteric surfactant, 1-10 parts of conditioner, 2-10 parts of anti-dandruff agent, 2-8 parts of citric acid, 5-15 parts of lutein, 1-2 parts of soybean protein, 1-15 parts of essence, 0.1-1 part of preservative and 60-85 parts of water.

2. The anti-dandruff shampoo bubble as claimed in claim 1, which is composed of the following components in parts by weight: 12.5 parts of chelating agent, 53.4 parts of amino acid surfactant, 25 parts of nonionic surfactant, 13.8 parts of amphoteric surfactant, 6 parts of conditioner, 6.8 parts of anti-dandruff agent, 5.9 parts of citric acid, 11.5 parts of lutein, 1.5 parts of soybean protein, 10 parts of essence, 0.8 part of preservative and 76 parts of water.

3. The anti-dandruff shampoo bubble of claim 1, wherein the chelating agent is EDTA-2 Na.

4. The anti-dandruff shampoo bubble as claimed in claim 1, wherein the amino acid surfactant consists of sodium cocoyl glutamate, sodium cocoamidopropionate, sodium methyl cocoyl taurate in a mass ratio of 1-5:1-4: 1-5; the nonionic surfactant is PEG-80 sorbitan laurate.

5. The anti-dandruff shampoo bubble as claimed in claim 1, wherein the amphoteric surfactant is composed of lecithin, alkylamide phosphobetaine, N-alkylthio- β -aminopropionic acid in a mass ratio of 1-3:2-5: 1-4.

6. The anti-dandruff shampoo bubble of claim 1 wherein the conditioning agent is one or more of polyquaternium-7, PPG-3 octyl ether, or PPG-3 benzyl ether myristate.

7. The anti-dandruff shampoo bubble as claimed in claim 1, wherein the anti-dandruff agent is made from piroctone olamine, paeonol and dipotassium glycyrrhizinate at a mass ratio of 1-3:2-4: 1-2.

8. The anti-dandruff shampoo bubble of claim 1, wherein the preservative is comprised of sodium benzoate and phenoxyethanol in a weight ratio of 3: 5.

9. The method for producing anti-dandruff shampoo bubbles according to any one of claims 1 to 8, comprising the steps of:

s1, dissolving the chelating agent in water, stirring uniformly, then respectively adding the amino acid surfactant, the nonionic surfactant and the amphoteric surfactant with the formula ratio, and stirring at the rotating speed of 400-600rpm for 20-30min until the solution is colorless and transparent to obtain a mixed solution A;

s2, respectively slowly adding a conditioner, a scurf remover and citric acid into the mixed solution A prepared in the step S1, stirring at the rotating speed of 400-600rpm for 20-30min until the mixture is completely dissolved, and homogenizing for half an hour to prepare a mixed solution B;

s3, adding the essence and the preservative into the mixed solution B prepared in the step S2, and stirring for 15-25min at the rotating speed of 600-800rpm until the solution is colorless and transparent, thus obtaining the liquid.