CN110959007A - 作为acc抑制剂的化合物及其应用 - Google Patents

作为acc抑制剂的化合物及其应用 Download PDF

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CN110959007A
CN110959007A CN201880048775.2A CN201880048775A CN110959007A CN 110959007 A CN110959007 A CN 110959007A CN 201880048775 A CN201880048775 A CN 201880048775A CN 110959007 A CN110959007 A CN 110959007A
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alkyl
membered
radical
heteroatoms
alkylamino
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CN110959007B (zh
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王勇
赵立文
王亚洲
全旭
姜春环
陈宏雁
陈孟华
李超
廖业欣
刘奇
王琛
王海
杨圣伟
郑国闯
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Nanjing Sanhome Pharmaceutical Co Ltd
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Nanjing Sanhome Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

一类作为乙酰辅酶A羧化酶(ACC)抑制剂的化合物及其应用，具体地，提供式I所示的化合物或其异构体、药学上可接受的盐、溶剂化物、结晶或前药，它们的制备方法以及含有这些化合物的药物组合物和这些化合物或组合物用于治疗和/或预防ACC表达相关疾病，例如纤维化疾病、代谢性疾病、癌症或者组织增生类疾病的用途。该化合物对ACC具有良好的抑制活性，非常有望成为纤维化疾病、代谢性疾病、癌症或者组织增生类疾病的治疗药物。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201880048775.2A 2017-07-26 2018-07-25 作为acc抑制剂的化合物及其应用 Active CN110959007B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710616033 2017-07-26
CN2017106160332 2017-07-26
PCT/CN2018/096930 WO2019020041A1 (zh) 2017-07-26 2018-07-25 作为acc抑制剂的化合物及其应用

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CN110959007A true CN110959007A (zh) 2020-04-03
CN110959007B CN110959007B (zh) 2022-07-01

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US (1) US11186587B2 (zh)
EP (1) EP3660023B1 (zh)
JP (1) JP6919055B2 (zh)
KR (1) KR102418195B1 (zh)
CN (2) CN109305976B (zh)
CA (1) CA3070525C (zh)
TW (1) TW201910338A (zh)
WO (1) WO2019020041A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111484504A (zh) * 2019-01-25 2020-08-04 南京圣和药业股份有限公司 Acc抑制剂的光学异构体及其应用
CN113968871A (zh) * 2020-07-25 2022-01-25 南京圣和药业股份有限公司 苯基取代类acc抑制剂的晶型

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111201234A (zh) * 2017-07-17 2020-05-26 南京瑞捷医药科技有限公司 新型化合物及其作为acc抑制剂的用途
CN111848678A (zh) * 2019-04-30 2020-10-30 正大天晴药业集团股份有限公司 含磷类噻吩并嘧啶衍生物
CN112778325A (zh) * 2019-11-07 2021-05-11 南京瑞捷医药科技有限公司 一种acc抑制剂及其用途
WO2021112213A1 (ja) * 2019-12-05 2021-06-10 日本曹達株式会社 ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物、及びそれを含有する農園芸用殺菌剤又は医療用・動物用抗真菌剤
CN113967213A (zh) * 2020-07-25 2022-01-25 南京圣和药业股份有限公司 一种包含苯基取代类acc抑制剂的组合物及其用途
TW202233632A (zh) * 2021-02-07 2022-09-01 大陸商正大天晴藥業集團股份有限公司 噻吩并嘧啶衍生物

Citations (2)

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CN104105485A (zh) * 2011-11-11 2014-10-15 尼普斯阿波罗有限公司 Acc抑制剂和其用途
WO2017075056A1 (en) * 2015-10-26 2017-05-04 Gilead Apollo, Llc Acc inhibitors and uses thereof

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US20070208040A1 (en) * 2006-03-02 2007-09-06 Elfatih Elzein A2a adenosine receptor antagonists
WO2015007451A1 (en) * 2013-07-15 2015-01-22 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
EP3597271A1 (en) * 2015-01-09 2020-01-22 Gilead Apollo, LLC Acc inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease
WO2018133858A1 (en) 2017-01-22 2018-07-26 Sunshine Lake Pharma Co., Ltd. Thienopyrimidine derivative and use thereof in medicine
WO2018228369A1 (zh) * 2017-06-15 2018-12-20 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途
CN111201234A (zh) * 2017-07-17 2020-05-26 南京瑞捷医药科技有限公司 新型化合物及其作为acc抑制剂的用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104105485A (zh) * 2011-11-11 2014-10-15 尼普斯阿波罗有限公司 Acc抑制剂和其用途
WO2017075056A1 (en) * 2015-10-26 2017-05-04 Gilead Apollo, Llc Acc inhibitors and uses thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111484504A (zh) * 2019-01-25 2020-08-04 南京圣和药业股份有限公司 Acc抑制剂的光学异构体及其应用
CN111484504B (zh) * 2019-01-25 2024-05-10 南京圣和药业股份有限公司 Acc抑制剂的光学异构体及其应用
CN113968871A (zh) * 2020-07-25 2022-01-25 南京圣和药业股份有限公司 苯基取代类acc抑制剂的晶型

Also Published As

Publication number Publication date
CA3070525C (en) 2022-03-15
CN109305976A (zh) 2019-02-05
US20200165265A1 (en) 2020-05-28
EP3660023A4 (en) 2021-05-26
EP3660023B1 (en) 2023-03-08
EP3660023A1 (en) 2020-06-03
WO2019020041A1 (zh) 2019-01-31
CN109305976B (zh) 2022-07-01
CA3070525A1 (en) 2019-01-31
CN110959007B (zh) 2022-07-01
JP2020527160A (ja) 2020-09-03
KR20200032158A (ko) 2020-03-25
JP6919055B2 (ja) 2021-08-11
TW201910338A (zh) 2019-03-16
US11186587B2 (en) 2021-11-30
KR102418195B1 (ko) 2022-07-07

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