CN110946772A - Toothpaste for preventing dental diseases and preparation method thereof - Google Patents
Toothpaste for preventing dental diseases and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Abstract
The invention provides toothpaste for preventing dental diseases and a preparation method thereof, belonging to the field of dental preparations. The invention overcomes the defect that the antibacterial agent and the abrasive agent used in the toothpaste in the prior art are not green enough, and the inflammation detection agent is added to effectively monitor the oral diseases. The dental sealant is prepared from 40-50 parts by weight of an abrasive, 10-30 parts by weight of a humectant, 1-5 parts by weight of a thickener, 1-3 parts by weight of a foaming agent, 0.1-1 part by weight of a natural preservative, 0.5-1 part by weight of an inflammation detection agent, 0.5-2 parts by weight of a tooth curing agent and 10-30 parts by weight of water. The toothpaste for preventing the odontopathy provided by the invention not only has the functions of strengthening enamel and resisting and inhibiting bacteria, but also has the function of monitoring the odontopathy.
Description
Technical Field
The invention belongs to the field of dental preparations, and particularly relates to toothpaste for preventing dental diseases and a preparation method thereof.
Background
Toothpaste is a common cleaning product in daily life and has a long history. With the continuous development of science and technology, the continuous improvement and perfection of technological equipment, various types of toothpaste are developed in succession, the quality and the grade of products are continuously improved, and the existing toothpaste variety is developed into multifunctional toothpaste with complete variety, multiple functions and hundreds of brands from single clean toothpaste, so that the requirements of consumption levels of different levels are met.
The toothpaste is an auxiliary product for tooth brushing, and has the effects of rubbing, removing bacterial plaque, cleaning and polishing tooth surface, and refreshing oral cavity.
Toothpastes are generally composed of powdered abrasives, humectants, surfactants, binders, flavorants, sweeteners, and other specific ingredients.
Existing toothpastes also often contain antibacterial and bacteriostatic agents, most of The toothpastes are selected from triclosan or triclocarban, however according to The common used antibacterial additive triclosan a liverstemor promoter (Proc Natl Acad Sci,2014,111(48): 17200-: endocrine disorders, impaired muscle contractility, destruction of the aquatic ecosystem, etc., and yet another serious side effect-promotion of hepatocellular carcinoma (HCC) exacerbation. In mice fed chronically, scientists found that triclosan stimulates hepatocyte proliferation and a fibrotic response, with signs of oxidative stress. After mice were tumorigenic with the known carcinogenic compound, Diethylnitrosamine (DEN), triclosan greatly accelerated the development of hepatocellular carcinoma in mice, and was identified as a liver tumor progression promoter. Triclosan-treated mice showed significant increases in tumor number, size and incidence compared to control mice. These results strongly suggest that chronic exposure to triclosan has a negative impact on mouse health, particularly in terms of liver fibrosis and tumor progression.
In addition, modern enamel is eroded by various acidic foods, such as freshly squeezed fruit juice, cola, wine and other drinks which are popular to people and pleasant to hear, the pH value of the drinks is lower than 4, and the drinks can cause great damage to teeth.
Disclosure of Invention
In order to solve the above-mentioned disadvantages, the present invention provides a toothpaste for preventing dental diseases and a method for preparing the same, which contains a tooth curing agent and an inflammation detecting agent in addition to an abrasive agent, a humectant, a thickener, a foaming agent, and a preservative, which are included in conventional toothpastes, so that not only the teeth of users of the toothpaste are made more acid-resistant, but also whether the teeth are inflamed or not can be diagnosed more conveniently and rapidly.
Specifically, the invention is realized by the following technical scheme:
the toothpaste for preventing the odontopathy is prepared from the following raw materials in parts by weight:
40-50 parts of an abrasive, 10-30 parts of a humectant, 1-5 parts of a thickener, 1-3 parts of a foaming agent, 0.5-2 parts of a tooth curing agent and 10-30 parts of water;
the tooth curing agent is any one of ferrihydrite powder, goethite powder, tetragonal fine ferrite powder, hematite powder and ferrite powder.
Preferably, the toothpaste also contains 0.1-1 weight part of natural preservative;
the natural preservative consists of neodimine and plant extract, wherein the content of neodimine is 0.05-0.10 per mill of the mass of the plant extract.
Preferably, the toothpaste further comprises 0.5-1 part by weight of an inflammation detection agent;
the inflammation detection agent consists of collagen and an activator, wherein the mass of the activator is 0.01-0.2% of that of the collagen;
the activator is acetylcysteine or a derivative thereof.
Preferably, the preparation method of the inflammation detection agent is to mix collagen and the activator uniformly.
Preferably, the abrasive agent is one or more of calcium hydrogen phosphate, calcium carbonate, silica, nut shell flour.
Preferably, the humectant is composed of one or more of glycerin, xylitol, sorbitol and polyethylene glycol.
Preferably, the thickener is any one of sodium carboxymethylcellulose, xanthan gum and hydroxymethyl guar gum.
Preferably, the foaming agent is any one or two of sodium cocoyl glutamate, sodium lauroyl sarcosinate and sodium dodecyl sulfate.
Preferably, the plant extract is any one or a mixture of two of hop extract, carob leaf extract and grape leaf extract in any proportion.
Preferably, the preparation method of the plant extract comprises the following steps: drying and grinding the plants, adding 90-95% (mass fraction) ethanol aqueous solution which is 3-5 times of the weight of the ground plants, refluxing for 2-3 hours, filtering, taking filter residue, drying, adding water which is 15-20 times of the weight of the filter residue, performing ultrasonic extraction for 60-120 minutes at 40-90 ℃, wherein the ultrasonic power is 100 plus 500W, centrifuging, and taking supernatant to obtain the plant extracting solution.
Preferably, the acetylcysteine derivative is methyl acetylcysteine or N-acetyl-S-methyl cysteine.
The preparation method of the toothpaste for preventing the odontopathy comprises the following steps: adding humectant, thickener and foaming agent into a container, adding water, stirring, sequentially adding abrasive and tooth curing agent, vacuum stirring for 2-3 hr, and standing for 2-3 hr to obtain toothpaste for preventing odontopathy.
Preferably, the method for preparing the above toothpaste for preventing dental diseases comprises the steps of: adding humectant, thickener, foaming agent, and natural antiseptic into container, adding water, stirring, sequentially adding friction agent and tooth curing agent, vacuum stirring for 2-3 hr, and standing for 2-3 hr to obtain toothpaste for preventing odontopathy.
Preferably, the method for preparing the above toothpaste for preventing dental diseases comprises the steps of: adding humectant, thickener, foaming agent, and inflammation detection agent into container, adding water, stirring, sequentially adding friction agent and tooth curing agent, vacuum stirring for 2-3 hr, and standing for 2-3 hr to obtain toothpaste for preventing odontopathy.
Preferably, the method for preparing the above toothpaste for preventing dental diseases comprises the steps of: adding humectant, thickener, foaming agent, natural antiseptic, and inflammation detection agent into container, adding water, stirring, sequentially adding friction agent and tooth curing agent, vacuum stirring for 2-3 hr, and standing for 2-3 hr to obtain toothpaste for preventing odontopathy.
The invention has the advantages that: a toothpaste has multiple purposes, and can be used for antibacterial tooth care and detection of inflammation of teeth. On the surface of medical research, the level of matrix metalloproteinase in saliva of patients with periodontitis and pulpitis is often obviously increased, the enzymes can specifically cut off collagen to release a certain amount of bitter peptides, and then the content of the bitter peptides in the collagen is often not enough to enable a human body to feel enough bitter, so that partial activators need to be added, and the acetylcysteine and derivatives thereof have good effects of activating the activity of matrix metalloproteinase after screening. The plant extract selected by the invention has multiple purposes, is used as a preservative and a sweetener, however, plant flavonoid substances are inevitably carried in the plant extraction process, and have bitter taste, so that the bitter taste of the substances is prevented from being confused with the bitter taste released by bitter peptides, and the bitter taste of the plants is specifically covered by adding neotamine. In addition, the nut shell powder is also selected as an abrasive, so that on one hand, the environment is protected, and on the other hand, the nut shell powder has special light fragrance and can increase the flavor of the toothpaste.
Detailed Description
The present invention is further illustrated by the following specific examples, which are provided for the purpose of illustration only and are not intended to be limiting.
Specifically, the source of the feedstock or CAS number used in the following examples is as follows:
hematite powder with the structural formula of α -Fe2O3Purchased from a mineral processing factory in Lingshou county and sieved with a 1000-mesh sieve before use.
The goethite powder, the structural formula of which is α -FeOOH, is prepared by referring to the optimal preparation conditions in the text of the influence of the preparation conditions on the synthesis of goethite (environmental chemistry, 2012,31(10):1625-1630.), and is sieved by a 1000-mesh sieve before use.
The structural formula of the ferrihydrite powder is Fe5HO8·H2O, is obtained by self-preparation according to the preparation method in the research on the adsorption performance of As (III) by ferrihydrite (Zhejiang agricultural science, 2012,24(3): 490-493), and is sieved with a 1000-mesh sieve before use.
Calcium hydrogen phosphate, purchased from Guansu practice Co., Ltd. in Liyunggang, was sieved through 1000 mesh before use.
Nut shell flour, purchased from Shijiazhu color stone mining Co., Ltd, was passed through a 1000 mesh screen prior to use.
Glycerol, CAS number: 56-81-5.
Xylitol, CAS No.: 87-99-0.
Sorbitol, CAS No.: 50-70-4.
Xanthan gum, CAS No.: 11138-66-2.
Sodium lauroyl glutamate, CAS No.: 29923-31-7.
Sodium dodecyl sulfate, CAS No.: 2386-53-0.
The collagen is fishbone collagen, and is purchased from Zhengzhou Kangyuan chemical products Co.
New diosmin, CAS No.: 38665-01-9.
Acetylcysteine, CAS No.: 616-91-1.
S-methyl acetylcysteine, CAS No.: 16637-59-5.
Hop, a mature leaf of a plant known by Latin as Humulus lupulus.
Grape leaves, mature leaves of a plant known by latin under the name vitas vinifera l.
Carob leaves, mature leaves of a plant known by latin under the name Ceratonia siliqua lin.
The water is self-made distilled water.
Example 1
The toothpaste for preventing the odontopathy is prepared from the following raw materials in parts by weight:
50 parts of an abrasive, 22 parts of a humectant, 3 parts of a thickener, 2 parts of a foaming agent, 0.8 part of a tooth curing agent, 0.5 part of a natural preservative, 0.7 part of an inflammation detection agent and 24 parts of water;
the friction agent is calcium hydrophosphate and nut shell powder in a mass ratio of 3: 1;
the humectant is a mixture of glycerol, xylitol and sorbitol in a mass ratio of 4:1: 3;
the thickening agent is xanthan gum;
the foaming agent is a mixture of sodium lauroyl glutamate and sodium dodecyl sulfate in a mass ratio of 2: 1;
the tooth curing agent is hematite powder;
the natural preservative consists of neodimine and plant extract, wherein the content of neodimine is 0.05 per mill of the mass of the plant extract, and the neodimine and the plant extract are uniformly mixed according to a proportion to obtain the natural preservative;
the plant extract is a hop leaf extract, and the preparation method comprises the following steps: drying the hop leaves at 30 ℃ for 3 days, grinding the hop leaves into powder, sieving the powder by a 50-mesh sieve, adding 95 percent ethanol aqueous solution which is 3 times of the mass of the milled hop leaves and is refluxed at 90 ℃ for 2 hours, sieving the powder by a 100-mesh sieve, taking filter residues, drying the filter residues at 30 ℃ for 24 hours, adding water which is 15 times of the mass of the filter residues, ultrasonically extracting the mixture for 60 minutes at 40 ℃, wherein the ultrasonic power is 400W, centrifuging the mixture at 3000rpm, and taking supernatant to obtain hop leaf extracting solution;
the inflammation detection agent consists of collagen and an activator, wherein the mass of the activator is 0.05% of the mass of the collagen, and the collagen and the activator are uniformly mixed according to a proportion to obtain the inflammation detection agent;
the activator is acetylcysteine.
The preparation method of the toothpaste for preventing the odontopathy comprises the following steps: adding humectant, thickener, foaming agent, natural antiseptic, and inflammation detecting agent into container, adding water, stirring at 500rpm for 1 hr, sequentially adding abrasive and tooth curing agent, stirring at 200rpm under-0.08 MPa vacuum for 3 hr, and standing for 2 hr to obtain toothpaste for preventing odontopathy.
Example 2
The toothpaste for preventing the odontopathy is prepared from the following raw materials in parts by weight:
50 parts of an abrasive, 22 parts of a humectant, 3 parts of a thickener, 2 parts of a foaming agent, 0.8 part of a tooth curing agent, 0.5 part of a natural preservative, 0.7 part of an inflammation detection agent and 24 parts of water;
the friction agent is calcium hydrophosphate and nut shell powder in a mass ratio of 3: 1;
the humectant is a mixture of glycerol, xylitol and sorbitol in a mass ratio of 4:1: 3;
the thickening agent is xanthan gum;
the foaming agent is a mixture of sodium lauroyl glutamate and sodium dodecyl sulfate in a mass ratio of 2: 1;
the tooth curing agent is goethite powder;
the natural preservative consists of neodimine and plant extract, wherein the content of neodimine is 0.05 per mill of the mass of the plant extract, and the neodimine and the plant extract are uniformly mixed according to a proportion to obtain the natural preservative;
the plant extract is a hop leaf extract, and the preparation method comprises the following steps: drying the hop leaves at 30 ℃ for 3 days, grinding the hop leaves into powder, sieving the powder by a 50-mesh sieve, adding 95 percent ethanol aqueous solution which is 3 times of the mass of the milled hop leaves and is refluxed at 90 ℃ for 2 hours, sieving the powder by a 100-mesh sieve, taking filter residues, drying the filter residues at 30 ℃ for 24 hours, adding water which is 15 times of the mass of the filter residues, ultrasonically extracting the mixture for 60 minutes at 40 ℃, wherein the ultrasonic power is 400W, centrifuging the mixture at 3000rpm, and taking supernatant to obtain hop leaf extracting solution;
the inflammation detection agent consists of collagen and an activator, wherein the mass of the activator is 0.05% of the mass of the collagen, and the collagen and the activator are uniformly mixed according to a proportion to obtain the inflammation detection agent;
the activator is acetylcysteine.
The preparation method of the toothpaste for preventing the odontopathy comprises the following steps: adding humectant, thickener, foaming agent, natural antiseptic, and inflammation detecting agent into container, adding water, stirring at 500rpm for 1 hr, sequentially adding abrasive and tooth curing agent, stirring at 200rpm under-0.08 MPa vacuum for 3 hr, and standing for 2 hr to obtain toothpaste for preventing odontopathy.
Example 3
The toothpaste for preventing the odontopathy is prepared from the following raw materials in parts by weight:
50 parts of an abrasive, 22 parts of a humectant, 3 parts of a thickener, 2 parts of a foaming agent, 0.8 part of a tooth curing agent, 0.5 part of a natural preservative, 0.7 part of an inflammation detection agent and 24 parts of water;
the friction agent is calcium hydrophosphate and nut shell powder in a mass ratio of 3: 1;
the humectant is a mixture of glycerol, xylitol and sorbitol in a mass ratio of 4:1: 3;
the thickening agent is xanthan gum;
the foaming agent is a mixture of sodium lauroyl glutamate and sodium dodecyl sulfate in a mass ratio of 2: 1;
the tooth curing agent is ferrihydrite powder;
the natural preservative consists of neodimine and plant extract, wherein the content of neodimine is 0.05 per mill of the mass of the plant extract, and the neodimine and the plant extract are uniformly mixed according to a proportion to obtain the natural preservative;
the plant extract is a hop leaf extract, and the preparation method comprises the following steps: drying the hop leaves at 30 ℃ for 3 days, grinding the hop leaves into powder, sieving the powder by a 50-mesh sieve, adding 95 percent ethanol aqueous solution which is 3 times of the mass of the milled hop leaves and is refluxed at 90 ℃ for 2 hours, sieving the powder by a 100-mesh sieve, taking filter residues, drying the filter residues at 30 ℃ for 24 hours, adding water which is 15 times of the mass of the filter residues, ultrasonically extracting the mixture for 60 minutes at 40 ℃, wherein the ultrasonic power is 400W, centrifuging the mixture at 3000rpm, and taking supernatant to obtain hop leaf extracting solution;
the inflammation detection agent consists of collagen and an activator, wherein the mass of the activator is 0.05% of the mass of the collagen, and the collagen and the activator are uniformly mixed according to a proportion to obtain the inflammation detection agent;
the activator is acetylcysteine.
The preparation method of the toothpaste for preventing the odontopathy comprises the following steps: adding humectant, thickener, foaming agent, natural antiseptic, and inflammation detecting agent into container, adding water, stirring at 500rpm for 1 hr, sequentially adding abrasive and tooth curing agent, stirring at 200rpm under-0.08 MPa vacuum for 3 hr, and standing for 2 hr to obtain toothpaste for preventing odontopathy.
Example 4
The toothpaste for preventing the odontopathy is prepared from the following raw materials in parts by weight:
50 parts of an abrasive, 22 parts of a humectant, 3 parts of a thickener, 2 parts of a foaming agent, 0.8 part of a tooth curing agent, 0.5 part of a natural preservative, 0.7 part of an inflammation detection agent and 24 parts of water;
the friction agent is calcium hydrophosphate and nut shell powder in a mass ratio of 3: 1;
the humectant is a mixture of glycerol, xylitol and sorbitol in a mass ratio of 4:1: 3;
the thickening agent is xanthan gum;
the foaming agent is a mixture of sodium lauroyl glutamate and sodium dodecyl sulfate in a mass ratio of 2: 1;
the tooth curing agent is ferrihydrite powder;
the natural preservative consists of neodimine and plant extract, wherein the content of neodimine is 0.05 per mill of the mass of the plant extract, and the neodimine and the plant extract are uniformly mixed according to a proportion to obtain the natural preservative;
the plant extract is grape leaf extract, and the preparation method comprises the following steps: drying grape leaves at 30 ℃ for 3 days, grinding the grape leaves into powder, sieving the powder by a 50-mesh sieve, adding 95% ethanol aqueous solution which is 3 times of the mass of the ground hop leaves, refluxing the mixture at 90 ℃ for 2 hours, filtering the mixture by a 100-mesh sieve, taking filter residues, drying the filter residues at 30 ℃ for 24 hours, adding water which is 15 times of the mass of the filter residues, performing ultrasonic extraction at 60 ℃ for 60 minutes, performing centrifugation at 3000rpm under the ultrasonic power of 600W, and taking supernate to obtain grape leaf extracting solution;
the inflammation detection agent consists of collagen and an activator, wherein the mass of the activator is 0.05% of the mass of the collagen, and the collagen and the activator are uniformly mixed according to a proportion to obtain the inflammation detection agent;
the activator is acetylcysteine.
The preparation method of the toothpaste for preventing the odontopathy comprises the following steps: adding humectant, thickener, foaming agent, natural antiseptic, and inflammation detecting agent into container, adding water, stirring at 500rpm for 1 hr, sequentially adding abrasive and tooth curing agent, stirring at 200rpm under-0.08 MPa vacuum for 3 hr, and standing for 2 hr to obtain toothpaste for preventing odontopathy.
Example 5
The toothpaste for preventing the odontopathy is prepared from the following raw materials in parts by weight:
50 parts of an abrasive, 22 parts of a humectant, 3 parts of a thickener, 2 parts of a foaming agent, 0.8 part of a tooth curing agent, 0.5 part of a natural preservative, 0.7 part of an inflammation detection agent and 24 parts of water;
the friction agent is calcium hydrophosphate and nut shell powder in a mass ratio of 3: 1;
the humectant is a mixture of glycerol, xylitol and sorbitol in a mass ratio of 4:1: 3;
the thickening agent is xanthan gum;
the foaming agent is a mixture of sodium lauroyl glutamate and sodium dodecyl sulfate in a mass ratio of 2: 1;
the tooth curing agent is ferrihydrite powder;
the natural preservative consists of neodimine and plant extract, wherein the content of neodimine is 0.05 per mill of the mass of the plant extract, and the neodimine and the plant extract are uniformly mixed according to a proportion to obtain the natural preservative;
the plant extracting solution is a mixture of grape leaf extracting solution and lupulus leaf extracting solution in a mass ratio of 1:1, wherein the preparation method of the grape leaf extracting solution is the same as that of the embodiment 4. The preparation method of the lupulus leaf extract is the same as that of the example 1;
the inflammation detection agent consists of collagen and an activator, wherein the mass of the activator is 0.05% of the mass of the collagen, and the collagen and the activator are uniformly mixed according to a proportion to obtain the inflammation detection agent;
the activator is acetylcysteine.
The preparation method of the toothpaste for preventing the odontopathy comprises the following steps: adding humectant, thickener, foaming agent, natural antiseptic, and inflammation detecting agent into container, adding water, stirring at 500rpm for 1 hr, sequentially adding abrasive and tooth curing agent, stirring at 200rpm under-0.08 MPa vacuum for 3 hr, and standing for 2 hr to obtain toothpaste for preventing odontopathy.
Example 6
The toothpaste for preventing the odontopathy is prepared from the following raw materials in parts by weight:
50 parts of an abrasive, 22 parts of a humectant, 3 parts of a thickener, 2 parts of a foaming agent, 0.8 part of a tooth curing agent, 0.5 part of a natural preservative, 0.7 part of an inflammation detection agent and 24 parts of water;
the friction agent is calcium hydrophosphate and nut shell powder in a mass ratio of 3: 1;
the humectant is a mixture of glycerol, xylitol and sorbitol in a mass ratio of 4:1: 3;
the thickening agent is xanthan gum;
the foaming agent is a mixture of sodium lauroyl glutamate and sodium dodecyl sulfate in a mass ratio of 2: 1;
the tooth curing agent is ferrihydrite powder;
the natural preservative consists of neodimine and plant extract, wherein the content of neodimine is 0.05 per mill of the mass of the plant extract, and the neodimine and the plant extract are uniformly mixed according to a proportion to obtain the natural preservative;
the plant extracting solution is a mixture of grape leaf extracting solution and lupulus leaf extracting solution in a mass ratio of 1:1, wherein the preparation method of the grape leaf extracting solution is the same as that of the embodiment 4. The preparation method of the lupulus leaf extract is the same as that of the example 1;
the inflammation detection agent consists of collagen and an activator, wherein the mass of the activator is 0.05% of the mass of the collagen, and the collagen and the activator are uniformly mixed according to a proportion to obtain the inflammation detection agent;
the activator is S-methyl acetylcysteine.
The preparation method of the toothpaste for preventing the odontopathy comprises the following steps: adding humectant, thickener, foaming agent, natural antiseptic, and inflammation detecting agent into container, adding water, stirring at 500rpm for 1 hr, sequentially adding abrasive and tooth curing agent, stirring at 200rpm under-0.08 MPa vacuum for 3 hr, and standing for 2 hr to obtain toothpaste for preventing odontopathy.
Test example 1
Tooth hardness test
The molar teeth of brown mice were treated with the toothpastes for preventing dental diseases prepared in examples 1 to 6, and then subjected to a tooth hardness test.
The treatment method comprises the following steps: taking 21 molars of normal-developing adult brown rats with similar sizes, removing soft tissues at the root parts of the teeth, removing the tooth roots and the dental pulp, polishing the dental crowns, washing the teeth for 10s with clear water, drying the teeth by an air gun, randomly dividing the teeth into 7 groups, soaking the teeth in 10mL of commercially available classical-taste coca cola, taking the teeth out after 3 days, washing the teeth for 1min with deionized water, wherein six groups are respectively coated on the toothbrush with the toothpaste prepared in the embodiment 1-6 for washing, the dosage of each tooth toothpaste is 0.3g, the washing time is 2 min/tooth, the teeth are washed with the deionized water for 1min after the washing is finished, then the teeth are soaked in 10mL of deionized water, the experiment lasts for 15 days, and the control group is soaked in the deionized water for 15 days. And after the experiment of the last day is finished, all the teeth are washed clean by deionized water and then dried by an air gun, the microhardness is tested, a Vickers pressure head is selected, three points are taken from each tooth, the average value is the microhardness of the tooth, and the average hardness of three teeth in each group is the microhardness of the tooth in the group.
The test results are shown in table 1.
TABLE 1 tooth hardness
| Microhardness (MPa) | |
| Example 1 | 195.72 |
| Example 2 | 211.33 |
| Example 3 | 276.42 |
| Example 4 | 275.58 |
| Example 5 | 277.39 |
| Example 6 | 300.35 |
| Comparative example | 96.40 |
The above table shows that the toothpaste for preventing dental diseases provided by the invention is helpful for preventing and treating teeth in an acidic environment for a long time, has a protective effect on teeth, wherein the effects brought by tooth firming agents of different crystal forms are different, the effect is best when ferrihydrite is used as the tooth firming agent, and surprisingly, the micro-hardness of the teeth can be slightly increased by adding S-methyl acetylcysteine.
Test example 2
Antibacterial testing
The experiments of the inhibition zone of the toothpaste in examples 1-6 were tested by referring to the article "research on the inhibition zone of propolis toothpaste" (oral care products industry, 2014,24(4): 20-22.). Diluting the toothpaste to be tested into 1: 20 for experiment, the experimental strains are Escherichia coli (8099), Staphylococcus aureus (ATCC6538), Candida albicans (ATCC10231), and Pseudomonas aeruginosa (ATCC 9027). The preparation concentrations of the bacterial solutions were 5X 106cfu/mL。
The results of the experiment are shown in table 2. The experimental values in the table are in mm, expressed as the bacteriostatic diameter.
TABLE 2 bacteriostatic ring test results (mm)
As can be seen from the above table, the toothpaste provided by the invention can obtain better antibacterial and bacteriostatic effects under the condition of using a green natural extract without using the traditional antibacterial agents triclosan or triclocarban.
Claims (10)
1. The toothpaste for preventing the odontopathy is characterized by comprising the following raw materials in parts by weight:
40-50 parts of an abrasive, 10-30 parts of a humectant, 1-5 parts of a thickener, 1-3 parts of a foaming agent, 0.5-2 parts of a tooth curing agent and 10-30 parts of water;
the tooth curing agent is any one of ferrihydrite powder, goethite powder, tetragonal fine ferrite powder, hematite powder and ferrite powder.
2. The toothpaste for preventing dental diseases according to claim 1, further comprising 0.1 to 1 part by weight of a natural preservative;
the natural preservative consists of neodimine and plant extract, wherein the content of neodimine is 0.05-0.10 per mill of the mass of the plant extract.
3. The toothpaste for preventing dental diseases according to claim 1 or 2, further comprising 0.5 to 1 part by weight of an inflammation detecting agent;
the inflammation detection agent consists of collagen and an activator, wherein the mass of the activator is 0.01-0.2% of that of the collagen;
the activator is acetylcysteine or a derivative thereof.
4. The toothpaste according to claim 1, wherein the abrasive is one or more of calcium hydrogen phosphate, calcium carbonate, silica, nut shell flour.
5. The toothpaste for preventing dental diseases according to claim 1, wherein the humectant consists of one or more of glycerin, xylitol, sorbitol and polyethylene glycol.
6. The toothpaste according to claim 1, wherein the thickener is any one of sodium carboxymethylcellulose, xanthan gum and hydroxymethyl guar gum.
7. The toothpaste for preventing dental diseases according to claim 1, wherein the foaming agent is composed of any one or two of sodium cocoyl glutamate, sodium lauroyl sarcosinate and sodium dodecyl sulfate.
8. The toothpaste according to claim 2, wherein the plant extract is one or a mixture of two of hop extract, carob leaf extract and grape leaf extract at any ratio.
9. The toothpaste for preventing dental diseases according to claim 3, wherein the acetylcysteine derivative is methyl acetylcysteine or N-acetyl-S-methylcysteine.
10. A method of preparing a dental cream for the prophylaxis of dental conditions according to any one of claims 3 to 9, characterised by the steps of: adding humectant, thickener, foaming agent, natural antiseptic, and inflammation detection agent into container, adding water, stirring, sequentially adding friction agent and tooth curing agent, vacuum stirring for 2-3 hr, and standing for 2-3 hr to obtain toothpaste for preventing odontopathy.
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