CN110946642A - High-frequency bipolar unrecoverable electroporation system - Google Patents
High-frequency bipolar unrecoverable electroporation system Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00613—Irreversible electroporation
Abstract
A high-frequency bipolar unrecoverable electroporation system comprises an upper information management module, a lower computer control module and a bipolar high-voltage pulse discharge circuit; the upper layer information management module receives the set working parameters and then transmits the working parameters to the lower computer control module, and then generates a control signal and transmits the control signal to the bipolar high-voltage pulse discharge circuit to generate bipolar high-voltage pulses. Compared with the traditional unipolar irreversible electroporation pulse sequence, the method can better and more uniformly improve the induced transmembrane potential of the closely-arranged cells to the simulated electroporation threshold value, thereby enabling the ablation area to be more uniform. The invention can achieve the purposes of good tumor ablation effect and tumor growth inhibition, and has good safety and effectiveness.
Description
Technical Field
The invention relates to the technical field of medical equipment for treating tumors, in particular to a high-frequency bipolar unrecoverable electroporation system.
Background
Tumors are a common disease and a frequently encountered disease, wherein malignant tumors are the most serious diseases which endanger human health at present. Since the pathogenesis and etiology of malignant tumors are not fully understood, fundamental preventive measures are lacking. To date, humans have not been able to cure malignant tumors as they do other common frequently encountered diseases. Because of the difficulty in treating malignant tumors, for centuries, various scholars treat malignant tumors by combining surgery and radiotherapy and chemotherapy to achieve a longer life span. However, radiotherapy and chemotherapy have great influence on human immunity and seriously affect the quality of life.
Irreversible Electroporation (IRE) is an emerging non-thermal ablation technique for treating tumors. The micro-second high-voltage discharge pulse is used to form nanometer pores on the cell membrane of the affected cell, so as to change the permeability of the cell membrane, destroy the homeostasis of the cell and further cause apoptosis, and the process is called irreversible electroporation. A typical treatment scheme of irreversible electroporation is to transmit a square wave pulse with a voltage of 1500v/cm and a pulse width of 50-100 mus in a single direction between two electrode needles, and the number of pulses is 70-100. The number of electrodes, the distance between the electrodes and the exposed length of the electrodes can be adjusted according to the size and the shape of the tumor in the treatment process. When the IRE is used, most importantly, the electric field does not cause thermal effect while damaging cell membranes, so that the tissue damage is caused, therefore, the IRE has wide application prospect in clinic, and particularly for the focus close to important blood vessels and nerves, the IRE can carry out minimally invasive ablation, and the treatment safety is improved.
Although IRE has good clinical prospect, the existing irreversible electroporation adopts unipolar high-voltage discharge pulse to act on cells, when the technique is used for irreversible ablation of tumor cells of a human body, the pulse discharge can cause large convulsion of muscles of a patient at the moment of pulse discharge, so that the limbs of the patient can be induced to move greatly, and the position fixation and treatment effect of a discharge electrode are seriously influenced. Therefore, at present, the trachea intubation, general anesthesia, muscle relaxant injection and ventilator assistance are needed for the patient in the implementation of such a surgery, the surgery cannot be conveniently performed under local anesthesia as most of the currently applied clinical interventional minimally invasive surgeries, the surgery process is complicated, the cost is high, the complexity and the risk of the ablation surgery are increased, and some complications may be caused, so that the application and the popularization of the technology are limited.
Disclosure of Invention
In order to solve the problems in the prior IRE technology, the invention provides a high-frequency bipolar unrecoverable electroporation system, realizes tumor ablation operation under the conditions of local anesthesia, no muscle relaxant injection and no mechanical ventilation of a breathing machine, and fundamentally improves the safety and quality of the operation.
The invention is realized by the following technical scheme:
the invention provides a high-frequency bipolar unrecoverable electroporation system which comprises an upper-layer information management module, a lower-layer computer control module and a bipolar high-voltage pulse discharge circuit, wherein the upper-layer information management module is connected with the lower-layer computer control module;
the upper layer information management module receives the set working parameters and transmits the working parameters to the lower computer control module;
the lower computer control module generates a control signal according to the working parameters transmitted by the upper information management module and transmits the control signal to the bipolar high-voltage pulse discharge circuit so as to control the charge and discharge parameters of the bipolar high-voltage pulse discharge circuit and enable the bipolar high-voltage pulse discharge circuit to generate bipolar high-voltage pulses;
the bipolar high-voltage pulse discharge circuit generates positive and negative bipolar high-voltage pulses, discharges the positive and negative bipolar high-voltage pulses through electrodes in the circuit, and transmits a feedback signal back to the upper information management module.
Furthermore, the upper information management module comprises an operation unit, a data processing unit, a display unit and a transmission unit;
the operation unit provides an interaction path for setting working parameters;
the data processing unit processes data to obtain a processing result;
the display unit displays an interactive interface and a processing result;
the transmission unit is used for transmitting working parameters and/or control signals.
Further, the system comprises a compiling unit for providing a programming environment to control the discharging sequence of the system.
Furthermore, the lower computer control module also comprises a high-frequency bipolar pulse generation control unit, a time sequence function control unit and a collection unit;
the high-frequency bipolar pulse generation control unit is used for generating a high-frequency bipolar pulse sequence;
the time sequence function control unit is used for controlling a charge and discharge switch in the charge and discharge circuit;
the acquisition unit is used for monitoring and acquiring voltage and/or current in the charging and discharging process.
Further, the charge and discharge parameters include a charge voltage, a discharge pulse voltage, a pulse width, a number of group pulses, and a number of pulse groups.
Further, the power amplifier circuit is used for transmitting the control signal to the bipolar high-voltage pulse discharge circuit after power amplification.
And the system further comprises a voltage/current detection circuit, which is used for detecting a system charging voltage feedback signal, a high-voltage pulse discharging voltage and a current feedback signal and uploading a detection result to the upper information management module.
Further, the photoelectric isolation module comprises a first photoelectric isolation unit and a second photoelectric isolation unit;
the first photoelectric isolation unit performs photoelectric isolation on the control signal;
the second photoelectric isolation unit performs photoelectric isolation on the feedback signal.
Furthermore, the device also comprises a signal filtering unit, wherein the signal filtering unit is used for filtering the feedback signal input by the bipolar high-voltage pulse discharging circuit.
Furthermore, the bipolar high-voltage pulse discharge circuit comprises a charging power supply, an energy storage capacitor bank, a fast electronic switch bank and a discharge electrode;
the energy storage capacitor group is connected with the charging power supply through a charging switch and is connected with the discharging electrode through the rapid electronic switch group;
the fast electronic switch group is connected with the discharge electrode through a discharge switch.
Further, the energy storage capacitor bank comprises one or more large-capacity capacitors and one or more small-capacity capacitors;
the large-capacity capacitor is connected with the small-capacity capacitor in parallel;
the capacity of the large-capacity capacitor is 100-400 uF; the capacity of the small-capacity capacitor is 0.1 uF-1 uF.
Further, two charging switches KJ1 and KJ2 are included;
two resistors R1 and R4 are connected in series, one end of the resistor is arranged between the two charging switches KJ1 and KJ2, and the other end of the resistor is grounded;
and a first feedback signal point is arranged between the two resistors, and the generated first feedback signal is fed back to the upper information management module.
Further, two discharge switches KJ3 and KJ4 are included, each of which is connected to one of the discharge electrodes to alternately discharge in a bipolar manner;
after being connected in series, one end of two resistors R2 and R3 is connected between the fast electronic switch group and KJ3, and the other end is grounded;
a second feedback signal point is arranged between the two resistors R2 and R3, and a generated second feedback signal is fed back to the upper information management module.
Further, a plurality of discharge switches are included, and each discharge switch is connected with one discharge electrode;
the selection of the discharge electrodes and the discharge sequence are controlled by the setting of the operating parameters.
Furthermore, the charging voltage is 1000v-5000v, the discharging pulse voltage is 1000v-5000v, the pulse width is 2 mus-50 mus, the number of group pulses is 1-15 and the number of pulse groups is 1-250.
In summary, the present invention provides a high-frequency bipolar unrecoverable electroporation system, which comprises an upper information management module, a lower computer control module and a bipolar high-voltage pulse discharge circuit; the upper layer information management module receives the set working parameters and then transmits the working parameters to the lower computer control module, and then generates a control signal and transmits the control signal to the bipolar high-voltage pulse discharge circuit to generate bipolar high-voltage pulses. Compared with the traditional unipolar irreversible electroporation pulse sequence, the method can better and more uniformly improve the induced transmembrane potential of the closely-arranged cells to the simulated electroporation threshold value, thereby enabling the ablation area to be more uniform. The invention can achieve the purposes of good tumor ablation effect and tumor growth inhibition, and has good safety and effectiveness.
Compared with the prior art, the invention has the following advantages:
1. before the patient is treated, the patient only needs local anesthesia.
2. The invention can lead the tumor ablation area of the patient to be more uniform.
3. The invention can accurately set the parameters of the bipolar pulse.
4. The invention is based on a high-speed digital signal microprocessor, collects high-voltage pulse feedback signals at high speed in real time, realizes the real-time monitoring of high-voltage pulse discharge in the whole treatment process, and meets the requirement on real-time performance in the working process of the system.
5. The invention adopts bipolar pulse discharge of a plurality of electrodes, and on the setting of a treatment area, high-voltage steep pulse forms a reticular discharge area in the tissue, so that an effective irreversible electric field covers the tumor tissue as much as possible, ablation blind areas are reduced, the effectiveness of a treatment plan is enhanced,
6. The output pulse form of the invention is a form that pulses with the same pulse width between 2us and 50us are conducted alternately between two electrodes.
7. The invention has good software and hardware protection mechanism and ensures the safety of the whole operation treatment.
Drawings
FIG. 1 is a block diagram of the high frequency bipolar non-recoverable electroporation system of the present invention;
FIG. 2 is a block diagram of a high frequency bipolar non-recoverable electroporation system according to an embodiment of the present invention;
FIG. 3 is a flow chart of a method for controlling a high frequency bipolar non-recoverable electroporation system according to an embodiment of the present invention;
fig. 4 is a circuit schematic of a bi-directional high voltage pulse discharge circuit in accordance with an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail with reference to the accompanying drawings in conjunction with the following detailed description. It should be understood that the description is intended to be exemplary only, and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
The invention provides a high-frequency bipolar unrecoverable electroporation system, which comprises an upper information management module, a lower computer control module and a bipolar high-voltage pulse discharge circuit, wherein the upper information management module is connected with the lower computer control module; the upper layer information management module receives the set working parameters and transmits the working parameters to the lower computer control module; the lower computer control module generates a control signal according to the working parameters transmitted by the upper information management module and transmits the control signal to the bipolar high-voltage pulse discharge circuit so as to control the charge and discharge parameters of the bipolar high-voltage pulse discharge circuit and enable the bipolar high-voltage pulse discharge circuit to generate bipolar high-voltage pulses; the bipolar high-voltage pulse discharge circuit generates positive and negative bipolar high-voltage pulses, discharges the positive and negative bipolar high-voltage pulses through electrodes in the circuit, and transmits a feedback signal back to the upper information management module.
Further, as shown in fig. 2, the upper layer information management module includes an operation unit, a data processing unit, a display unit, and a transmission unit; the operation unit provides an interactive way for setting various working parameters for an operator and downloads the set working parameters to the lower computer control module. The data processing unit processes the data to obtain a processing result; for example, various data collected by the control module are processed and plotted into a curve. The display unit displays an interactive interface and a processing result, so that data is visualized, and information such as charging and discharging processes is provided for an operator. The transmission unit is used for transmitting the working parameters and/or the control signals. In a specific embodiment, the upper layer information management module is a medical computer.
Furthermore, the upper information management module further comprises a compiling unit for providing a programming environment for an operator and realizing intelligent control of the system discharging sequence.
Furthermore, the lower computer control module takes a field programmable gate array (FPGA or CPLD) and a Digital Signal Processor (DSP) as a central controller to realize the control of charging and discharging of the bipolar high-voltage pulse discharge circuit and the monitoring and acquisition of charging and discharging feedback signals. The lower computer control module comprises a high-frequency bipolar pulse generation control unit, a time sequence function control unit and a collecting unit.
Further, the high-frequency bipolar pulse generation control unit is configured to generate a corresponding high-frequency bipolar pulse sequence according to the pulse parameter set by the upper layer information management module.
Further, the time sequence function control unit is used for controlling a charge and discharge switch in the charge and discharge circuit.
Further, the acquisition unit is used for monitoring and acquiring voltage and/or current in the charging and discharging process.
Further, the charge and discharge parameters include a charge voltage, a discharge pulse voltage, a pulse width, a number of group pulses, and a number of pulse groups.
Further, the power amplifier circuit is used for transmitting the control signal to the bipolar high-voltage pulse discharge circuit after power amplification.
Further, the system comprises a voltage/current detection circuit, which is used for detecting a voltage signal of a feedback signal point of the system charging circuit and a voltage and current signal of a feedback signal point of the bipolar high-voltage pulse discharging circuit.
Furthermore, the device also comprises a photoelectric isolation module which is used for performing photoelectric isolation on all input and output signals so as to reduce the noise interference of external noise signals on the internal control module and improve the reliability of the control module. Specifically, the optoelectronic isolation module comprises a first optoelectronic isolation unit and a second optoelectronic isolation unit; the first photoelectric isolation unit is used for performing photoelectric isolation on the control signal; the second photoelectric isolation unit performs photoelectric isolation on the feedback signal.
Furthermore, the device also comprises a signal filtering unit, wherein the signal filtering unit is used for filtering the feedback signal input by the bipolar high-voltage pulse discharging circuit.
The high frequency bipolar non-recoverable electroporation system of the present invention is further described below with reference to an embodiment. As shown in fig. 3, the system includes an upper information management module and a bipolar high-voltage pulse discharge circuit, wherein the upper information management module transmits a control signal generated by an input working parameter to the bipolar high-voltage pulse discharge circuit through a lower computer control module, a first photoelectric isolation unit and a power amplification circuit; the bipolar high-voltage pulse discharge circuit transmits a feedback signal back to the upper information management module through the voltage/current detection circuit, the second photoelectric isolation unit and the signal filtering unit.
Further, as shown in fig. 2, the bipolar high-voltage pulse discharge circuit includes a charging power supply, an energy storage capacitor bank, a fast electronic switch bank, and a discharge electrode; the energy storage capacitor group is connected with the charging power supply through a charging switch and is connected with the discharging electrode through the rapid electronic switch group; the fast electronic switch group is connected with the discharge electrode through a discharge switch. The fast electronic switch adopts an insulated gate bipolar transistor and is provided with an IGBT driving circuit. The energy storage capacitor bank comprises one or more large-capacity capacitors and one or more small-capacity capacitors; the large-capacity capacitor is connected with the small-capacity capacitor in parallel; the capacity of the large-capacity capacitor is 100-400 uF; the capacity of the small-capacity capacitor is 0.1 uF-1 uF.
Further, two charging switches are included; after the two resistors are connected in series, one end of each resistor is arranged between the two charging switches, and the other end of each resistor is grounded; a first feedback signal point is arranged between the two resistors, a generated first feedback signal is fed back to the upper information management module, and the first feedback signal is used for detecting the charging voltage.
Further, the device comprises two discharge switches, wherein each discharge switch is connected with a discharge electrode to discharge alternately in a bipolar mode; after the two resistors are connected in series, one end of each resistor is connected between the fast electronic switch group and one of the discharge switches, and the other end of each resistor is grounded; and a second feedback signal point is arranged between the two resistors, the generated second feedback signal is fed back to the upper information management module, and the second feedback signal is used for detecting the discharge voltage.
Further, the setting of the charge and discharge parameters may be selected as follows: the charging voltage is 1000v-5000v, the discharging pulse voltage is 1000v-5000v, the pulse width is 2 mus-50 mus, the number of group pulses is 1-15 and the number of pulse groups is 1-250; wherein, the number of the group pulses is the number of the pulses in each pulse group.
Further, a plurality of discharge switches may be included, each discharge switch being connected to one discharge electrode; thus, the selection of the discharge electrodes and the discharge sequence can be controlled by setting the working parameters of the upper information management module.
The bipolar high-voltage pulse discharge circuit of the present invention will be described below with an embodiment in which two discharge electrodes are used, but a plurality of discharge electrodes may be selected as needed in practical applications. Fig. 4 is a schematic circuit diagram of a bipolar high-voltage pulse discharge circuit according to an embodiment of the present invention, and as shown in fig. 4, the bipolar high-voltage pulse discharge circuit includes an energy storage capacitor bank C1-C6 connected to a charging power source U1, and a pair of discharge electrodes 1 and 2 connected to the energy storage capacitor bank through a fast electronic switch bank K1-K4. Charging switches KJ1 and KJ2 are arranged between the energy storage capacitor bank and a charging power supply, wherein G1 and G2 are control signals of KJ1 respectively, and G3 and G4 are control signals of KJ2 respectively; discharge switches KJ3 and KJ4 are arranged between the fast electronic switch and the discharge electrode, wherein G5 and G6 are control signals of KJ3 respectively, and G7 and G8 are control signals of KJ4 respectively. Specifically, the charge switches KJ1 and KJ2 and the discharge switches KJ3 and KJ4 may employ relays. The energy storage capacitor bank is formed by connecting one or more large-capacity capacitors of 100 uF-400 uF and one or more small-capacity capacitors of 0.1 uF-1 uF in parallel, so that large current can be supplied in a short time, and the rapid rise of current pulse is realized. As shown in the figure, the energy storage capacitor bank comprises three large-capacity capacitors C1, C3 and C5 which are connected in series, and three small-capacity capacitors C2, C4 and C6 which are connected in series and then connected in parallel.
The fast electronic switch group comprises 4 fast electronic switches K1-K4, insulated gate bipolar transistors IGBT are adopted, and an IGBT driving circuit is arranged. The energy storage capacitor bank is connected with the K1 and the K3 in series, and the K2 and the K4 in series respectively in parallel; one end of the discharge switch KJ3 is connected between K1 and K3, and the other end is connected with one discharge electrode in the discharge electrode pair; one end of the discharge switch KJ4 is connected between K2 and K4, and the other end is connected with the other discharge electrode in the discharge electrode pair, wherein the discharge switch KJ4 is connected with K2 and K4 through a resistor R5, and the resistor R5 plays a role in current limiting. Wherein, the resistance range of R5 can be 0.05-0.3 Ω, and the power limit is 5 OW.
After the two resistors R1 and R4 are connected in series, one end of each resistor is connected between the two charging switches KJ1 and KJ2, the other end of each resistor is grounded, a first feedback signal point is arranged between the resistors R1 and R4, and a voltage/current detection circuit measures a signal of the first feedback signal point and is used for detecting charging voltage; wherein J1, J2 are feedback signals of the charging voltage. After two resistors R2 and R3 are connected in series, one end of the resistor is connected between the midpoint of the fast electronic switches K1 and K3 and KJ3, the other end of the resistor is grounded and is connected with KJ4 through R5, a second feedback signal point is arranged between the resistors R3 and R4, and a voltage/current detection circuit measures a signal of the second feedback signal point and is used for detecting the discharge voltage; wherein J3 and J4 are feedback signals of the discharge voltage. Wherein the resistance range of R1 can be 750K-1M omega, and the power limit is 15W; the resistance range of R2 can be 75K-100K omega, and the power limit is 15W; the resistance range of R3 can be 100-1000 omega, and the power limit is 1W; the resistance range of R4 can be 1K-10K omega, and the power limit is 1W.
When the system works, the discharge electrode is inserted into a focus part, and the charge switches KJ1 and KJ2 are closed firstly to charge the energy storage capacitor bank. When the voltage at the point J1, i.e. the first feedback signal point, reaches a predetermined value, the charging switches KJ1 and KJ2 are opened, the discharging switches KJ3 and KJ4 are closed, and the energy storage capacitor bank is discharged. The fast electronic switch forms high-frequency and high-voltage pulses under the action of an IGBT driving circuit, the width of the pulses can be set to be between 2us and 50 mu s, and the pulses with the same pulse width are alternately conducted between two discharge electrodes.
A plurality of discharge electrodes can be selected to carry out bipolar pulse discharge, and the high-voltage steep pulse forms a reticular discharge area in the tissue on the setting of a treatment area, so that an effective irreversible electric field can cover the tumor tissue as much as possible, ablation blind areas are reduced, and the effectiveness of a treatment plan is enhanced; at the rising edge of the pulse, a perforation of the cells is achieved, the process of which is irreversible, thereby achieving cell inactivation.
The high-frequency bipolar unrecoverable electroporation system provided by the invention uses bipolar high-voltage pulses with nanosecond rising edges to perform nano-order electroporation on the outer membrane of the biological cells, so that the inactivation effect on the biological cells is realized. The system is applied to tumor treatment, can realize inactivation treatment of tumor fine application, and can achieve the effects of minimal invasion and no heat deposition. In addition, the irreversible electroporation only can perforate general tissue cells and does not work on connective tissue cells such as blood vessels, nerves and the like, and meanwhile, the high-frequency bipolar irreversible electroporation realizes tumor ablation operation under the conditions of local anesthesia, no muscle relaxant injection and no mechanical ventilation of a respirator, thereby fundamentally improving the safety and the quality of the operation.
The invention adopts the form of charging and discharging of a capacitor bank, takes a field programmable gate array (FPGA or CPLD) and a Digital Signal Processor (DSP) as a central controller, takes an insulated gate bipolar transistor (IGBD) as a steep pulse generating switch, can generate bipolar high-voltage pulses with the frequency of 250kHZ, has the output voltage of 1000v-5000v, and can regulate positive and negative pulses within the range of 2 mus-50 mus. The number of probes to be used (namely the number of discharge electrodes) and the combination of the probes (namely the selection of the discharge electrodes) are selected through a user operation interface, and parameters such as voltage (1000v-5000v), positive pulse width (2 mus-50 mus), negative pulse width (2 mus-50 mus), number of pulses in a group (1-15), number of pulse groups (1 group-250 groups) and the like are set through the electrode spacing.
In summary, the present invention provides a high-frequency bipolar unrecoverable electroporation system, which comprises an upper information management module, a lower computer control module and a bipolar high-voltage pulse discharge circuit; the upper layer information management module receives the set working parameters and then transmits the working parameters to the lower computer control module, and then generates a control signal and transmits the control signal to the bipolar high-voltage pulse discharge circuit to generate bipolar high-voltage pulses. Compared with the traditional unipolar irreversible electroporation pulse sequence, the method can better and more uniformly improve the induced transmembrane potential of the closely-arranged cells to the simulated electroporation threshold value, thereby enabling the ablation area to be more uniform. The invention can achieve the purposes of good tumor ablation effect and tumor growth inhibition, and has good safety and effectiveness.
It is to be understood that the above-described embodiments of the present invention are merely illustrative of or explaining the principles of the invention and are not to be construed as limiting the invention. Therefore, any modification, equivalent replacement, improvement and the like made without departing from the spirit and scope of the present invention should be included in the protection scope of the present invention. Further, it is intended that the appended claims cover all such variations and modifications as fall within the scope and boundaries of the appended claims or the equivalents of such scope and boundaries.
Claims (15)
1. A high-frequency bipolar unrecoverable electroporation system is characterized by comprising an upper information management module, a lower computer control module and a bipolar high-voltage pulse discharge circuit;
the upper layer information management module receives the set working parameters and transmits the working parameters to the lower computer control module;
the lower computer control module generates a control signal according to the working parameter transmitted by the upper information management module and transmits the control signal to the bipolar voltage pulse discharge circuit so as to control the charge-discharge parameter of the bipolar high-voltage pulse discharge circuit and enable the bipolar high-voltage pulse discharge circuit to generate bipolar high-voltage pulses;
the bipolar high-voltage pulse discharge circuit generates positive and negative bipolar high-voltage pulses, discharges the positive and negative bipolar high-voltage pulses through electrodes in the circuit, and transmits a feedback signal back to the upper information management module.
2. The system according to claim 1, wherein the upper information management module comprises an operation unit, a data processing unit, a display unit, and a transmission unit;
the operation unit provides an interaction path for setting working parameters;
the data processing unit processes data to obtain a processing result;
the display unit displays an interactive interface and a processing result;
the transmission unit is used for transmitting working parameters and/or control signals.
3. The system of claim 2, further comprising a compiling unit configured to provide a programming environment to control a discharge sequence of the system.
4. The system according to any one of claims 1-3, wherein the lower computer control module further comprises a high frequency bipolar pulse generation control unit, a timing function control unit and an acquisition unit;
the high-frequency bipolar pulse generation control unit is used for generating a high-frequency bipolar pulse sequence;
the time sequence function control unit is used for controlling a charge and discharge switch in the charge and discharge circuit;
the acquisition unit is used for monitoring and acquiring voltage and/or current in the charging and discharging process.
5. The system of claim 1, wherein the charge-discharge parameters include a charge voltage, a discharge pulse voltage, a pulse width, a number of group pulses, and a number of groups of pulses.
6. The system according to any one of claims 1-5, further comprising a power amplification circuit for transmitting a control signal to the bipolar high voltage pulse discharge circuit after power amplification.
7. The system according to any one of claims 1-6, further comprising a voltage/current detection circuit for detecting the system charging voltage feedback signal, the high voltage pulse discharging voltage and the discharging current feedback signal, and uploading the detection result to the upper information management module.
8. The system of any one of claims 1-7, further comprising a photovoltaic isolation module comprising a first photovoltaic isolation unit and a second photovoltaic isolation unit;
the first photoelectric isolation unit performs photoelectric isolation on the control signal;
the second photoelectric isolation unit performs photoelectric isolation on the feedback signal.
9. The system according to any one of claims 1 to 8, further comprising a signal filtering unit for filtering the feedback signal inputted from the bipolar high voltage pulse discharging circuit.
10. The system according to any one of claims 1-9, wherein the bipolar high voltage pulse discharge circuit comprises a charging power source, an energy storage capacitor bank, a fast electronic switch bank and a discharge electrode;
the energy storage capacitor group is connected with the charging power supply through a charging switch and is connected with the discharging electrode through the rapid electronic switch group;
the fast electronic switch group is connected with the discharge electrode through a discharge switch.
11. The system of claim 10, wherein the energy storage capacitor bank comprises one or more large capacity capacitors and one or more small capacity capacitors;
the large-capacity capacitor is connected with the small-capacity capacitor in parallel;
the capacity of the large-capacity capacitor is 100-400 uF; the capacity of the small-capacity capacitor is 0.1 uF-1 uF.
12. The system of claim 10 or 11, comprising two of the charge switches KJ1 and KJ 2;
two resistors R1 and R4 are connected in series, one end of the resistor is arranged between the two charging switches KJ1 and KJ2, and the other end of the resistor is grounded;
and a first feedback signal point is arranged between the two resistors, and the generated first feedback signal is fed back to the upper information management module.
13. The system according to any one of claims 11-12, comprising two of said discharge switches KJ3 and KJ4, each discharge switch being connected to one discharge electrode for bipolar alternate discharge;
after being connected in series, one end of two resistors R2 and R3 is connected between the fast electronic switch group and KJ3, and the other end is grounded;
a second feedback signal point is arranged between the two resistors R2 and R3, and a generated second feedback signal is fed back to the upper information management module.
14. The system of claim 10, comprising a plurality of discharge switches, each discharge switch connected to a discharge electrode;
the selection of the discharge electrodes and the discharge sequence are controlled by the setting of the operating parameters.
15. The system according to any one of claims 1 to 14, wherein the charging voltage is 1000v to 5000v, the discharging pulse voltage is 1000v to 5000v, the pulse width is 2 μ s to 50 μ s, the number of pulses in a group is 1 to 15, and the number of groups of pulses is 1 to 250.
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| CN112022331A (en) * | 2020-08-31 | 2020-12-04 | 天津市鹰泰利安康医疗科技有限责任公司 | Irreversible electroporation ablation system |
| CN113180818A (en) * | 2021-05-06 | 2021-07-30 | 上海玄宇医疗器械有限公司 | Device for cooperative work of high-voltage electric pulse ablation and electrophysiological recorder |
| CN113440247A (en) * | 2020-08-28 | 2021-09-28 | 苏州博思得电气有限公司 | High-frequency irreversible electroporation tumor treatment system |
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