CN111317558A - Tumor ablation equipment using ultrahigh-voltage positive-negative composite pulse electric field - Google Patents
Tumor ablation equipment using ultrahigh-voltage positive-negative composite pulse electric field Download PDFInfo
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- 239000000523 sample Substances 0.000 claims abstract description 45
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
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Abstract
The embodiment of the invention discloses a tumor ablation device applying an ultrahigh-voltage positive-negative composite pulse electric field, which relates to the field of tumor treatment devices, and comprises: the interaction device sends out a control instruction through gesture control; the host computer is electrically connected with the interactive device and is used for collecting and processing real-time data required by the operation, generating a control instruction and controlling the internal circuit to generate an ultrahigh voltage positive and negative composite pulse electric field; the probe is connected with a probe interface of the host, only one of the electric polarities of the probe interface is negative, and the rest of the electric polarities of the probe interface is positive, and the probe acts on the tumor cells. The embodiment of the invention can solve the problems that the existing tumor treatment equipment is easy to get an electric shock, and the treatment effect is not obvious due to inconvenient operation. The probe design of one negative five positive is adopted, the infrared gesture control technology is applied, safety and sterility are achieved, the operation environment of the operation is guaranteed, and the treatment efficiency is improved.
Description
Technical Field
The embodiment of the invention relates to the field of tumor treatment equipment, in particular to tumor ablation equipment applying an ultrahigh-voltage positive and negative composite pulse electric field.
Background
Nanosecond pulsed electric fields are gaining increasing attention in the biomedical field with their unique "intracellular electric processing" effect. The intracellular electric treatment effect means that under the action of an external nanosecond pulse, a biological effect which is completely different from a microsecond pulse electroporation phenomenon appears in a cell, namely, the obvious electroporation phenomenon does not appear on the surface of a cell membrane, but a series of functional changes appear in the cell such as cell nucleus, mitochondria and the like to generate a large number of micronuclei and induce the programmed cell death, also called apoptosis. Because the tumor cells and the normal cells have different resistance values, the nanosecond pulse electric fields with different strengths are utilized to puncture the tumor cells in the clinical treatment of tumor diseases, so that the tumor cells can be killed without damaging the normal cells, and the treatment effect is good.
Therefore, tumor ablation devices are produced at the same time, but the existing tumor ablation devices do not notice that tumor cells can change in size along with the progress of treatment, so that the set breakdown current is insufficient or too large to hurt normal cells; in addition, in the treatment process by utilizing the prior art, the muscle tremor of the patient is serious, the psychological burden of the patient is increased, the treatment is not facilitated, and the treatment effect is greatly influenced when the electricity of the equipment is applied to the affairs of doctors and patients because the existing tumor ablation technology needs a large voltage to make tumor cells die.
Disclosure of Invention
The embodiment of the invention aims to provide tumor ablation equipment using an ultrahigh-voltage positive-negative composite pulse electric field, which is used for solving the problems that the existing tumor treatment equipment is easy to get an electric shock and is inconvenient to operate, so that the treatment effect is not obvious.
In order to achieve the above object, the embodiments of the present invention mainly provide the following technical solutions:
the embodiment of the invention provides a tumor ablation device applying an ultrahigh voltage positive and negative composite pulse electric field,
the tumor ablation device comprises: the interaction device comprises a data screen and an operation screen, wherein the data screen is used for displaying real-time data required by a surgery, the operation screen is used for displaying a real-time picture of a surgical scalpel part, and the operation screen is provided with a gesture control module; the host computer is electrically connected with the interactive device and is used for collecting and processing real-time data required by the operation, generating a control instruction and controlling the internal circuit to generate an ultrahigh voltage positive and negative composite pulse electric field; the probe is connected with a probe interface of the host, only one of the electric polarities of the probe interface is negative, and the rest of the electric polarities of the probe interface is positive, and the probe acts on the tumor cells.
Further, the gesture control module comprises: an infrared emitter for emitting infrared rays to sense hand motion; and the infrared receiver is used for receiving the infrared rays reflected by the hand and sending the received infrared rays to the host, and the host judges the corresponding gesture action according to the intensity of the infrared rays, matches a control instruction corresponding to the gesture action and controls related equipment to execute the control instruction.
Furthermore, the host comprises a data acquisition unit, an electric field generation unit, a driving unit and a control unit, wherein the data acquisition unit is used for acquiring real-time data and sending the real-time data to the control unit, the control unit is used for processing the real-time data and then generating a driving signal, the driving unit is used for triggering the electric field generation unit according to the driving signal to generate a positive and negative composite pulse electric field, and the positive and negative composite pulse electric field is released through a probe and acts on tumor cells.
Furthermore, the acquisition unit adopts a CPLD module, is electrically connected with external equipment through an optical fiber interface circuit, and acquires the R waveform and the electrocardio trigger signal.
Further, the control unit comprises a control chip and a communication module, the control chip adopts a single chip microcomputer, the control chip is electrically connected with the acquisition unit, and the communication module is used for communicating the single chip microcomputer with an upper computer.
Furthermore, the driving unit is composed of a driving chip, a first operational amplifier, a second operational amplifier and an adjustable resistor, the driving chip is connected to the homodromous input end of the first operational amplifier, the output end of the first operational amplifier is connected to the inverted input end of the second operational amplifier, the adjustable resistor is connected with the power supply and the homodromous input end of the second operational amplifier, and the output end of the second operational amplifier outputs a driving signal.
Furthermore, the probe is a disposable electrode needle, and an insulating coating is coated on the needle head of the probe.
Furthermore, an isolation transformer is arranged in the probe interface with negative electric polarity.
The technical scheme provided by the embodiment of the invention at least has the following advantages:
the tumor ablation equipment using the ultrahigh-voltage positive-negative composite pulse electric field provided by the embodiment of the invention adopts a negative-five-positive probe design, and uses the ultrahigh-voltage positive-negative composite pulse to generate the electric field so as to achieve the purpose of ablating tumor cells.
Drawings
Fig. 1 is a schematic structural diagram of a tumor ablation apparatus using an ultra-high voltage positive-negative composite pulse electric field according to an embodiment of the present invention.
Fig. 2 is a circuit diagram of an optical fiber interface according to an embodiment of the present invention.
Fig. 3 is a pin connection diagram of a communication module according to an embodiment of the present invention.
Fig. 4 is a circuit connection diagram of a driving unit according to an embodiment of the present invention.
Fig. 5 is a circuit connection diagram of a composite pulse generating circuit according to an embodiment of the present invention.
Fig. 6 is a circuit diagram of the boost circuit according to the embodiment of the present invention.
Detailed Description
The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.
In the following description, for purposes of explanation and not limitation, specific details are set forth such as particular system structures, interfaces, techniques, etc. in order to provide a thorough understanding of the present invention. It will be apparent, however, to one skilled in the art that the present invention may be practiced in other embodiments that depart from these specific details. In other instances, detailed descriptions of well-known systems, circuits, and methods are omitted so as not to obscure the description of the present invention with unnecessary detail.
The embodiment of the invention provides a tumor ablation device using an ultrahigh voltage positive and negative composite pulse electric field, and with reference to fig. 1, the tumor ablation device mainly comprises: the medical treatment device comprises an interaction device 01, a host 02 and a probe 03, wherein the interaction device 01 realizes the interaction between a doctor and a treatment instrument, the host 02 is used for acquiring clinical data by using a medical acquisition means and processing the data, and the probe 03 acts on tumor cells of a patient by using a positive and negative composite pulse electric field generated in the host 02.
Specifically, the interaction device 01 comprises a data screen 04 and an operation screen 05, the data screen 04 is used for displaying real-time data required by an operation, the real-time data comprises the heart rate, the blood pressure, the white blood cell number of a patient, the size and the resistance value of tumor cells and the like, the heart rate and the R wave of the patient can be collected by the electrocardioscanner in the treatment process and then transmitted to the host 02, and the host 02 analyzes the data and uploads the data to the upper computer 11 at the same time, and the data are displayed on the data screen 04 in real time.
The operation screen 05 is used for displaying a real-time picture of a surgical operation scalpel part, and the operation screen 05 is provided with the gesture control module 06, so that a doctor needs to keep hands clean and cannot leave a patient far away during treatment, and if a second person except the doctor operates the equipment, the doctor cannot understand the meaning of the doctor by mistake, and inevitable medical accidents are caused. And adopt gesture control module 06 can avoid the doctor to touch treatment equipment, avoid breeding of bacterium, the doctor directly can realize the control to equipment at the corresponding gesture of appointed high stroke.
Gesture control module 06 sets up in operation screen 05, and gesture control module 06 includes: the hand motion sensing device comprises an infrared transmitter and an infrared receiver, wherein the infrared transmitter is used for transmitting infrared rays to sense hand motion; the infrared receiver is used for receiving infrared rays reflected by hands and sending the received infrared rays to the host 02, the host 02 judges the intensity of the infrared rays to obtain corresponding gesture actions, and the control instructions corresponding to the gesture actions are matched and control related equipment to execute the control instructions.
Further, the host 02 is electrically connected with the interactive device 01 and is used for collecting and processing real-time data required by the operation, generating a control instruction and controlling an internal circuit to generate an ultrahigh voltage positive and negative composite pulse electric field.
The host 02 comprises a data acquisition unit 07, an electric field generation unit 10, a driving unit 09 and a control unit 08, wherein the data acquisition unit 07 is used for acquiring real-time data and sending the real-time data to the control unit 08, the control unit 08 is used for processing the real-time data and then generating a driving signal, the driving unit 09 is used for triggering the electric field generation unit 10 to generate a positive and negative composite pulse electric field according to the driving signal, and the positive and negative composite pulse electric field is released through a probe 03 and acts on tumor cells.
The acquisition unit 07 adopts a complex programmable logic device CPLD module, is electrically connected with external equipment through an optical fiber interface circuit, and acquires R waveforms and electrocardio trigger signals. The CPLD collects data and sends the data to the single chip microcomputer for processing, and the single chip microcomputer sends the data to the upper computer 11 and receives a discharge signal of the upper computer 11. Referring to fig. 2, the optical fiber interface circuit is provided with an optical fiber input end, an optical fiber output end, an R wave receiving end and a trigger signal receiving end, wherein the optical fiber input end and the optical fiber output end are used for realizing communication between the circuit and external equipment, the R wave receiving end is used for receiving R waves detected by the electrocardiogram monitor, and the trigger signal receiving end is used for receiving a heart rate trigger signal, so that only when the heart is in a systolic period, the patient can be treated.
Control unit 08 includes control chip and communication module, and control chip adopts STM32 singlechip, and control chip is connected with acquisition unit 07 electricity, and communication module is used for the singlechip to communicate with host computer 11, and communication module adopts W5500SPI communication module, and the pin connection diagram refers to figure 3.
Referring to fig. 4, the driving unit 09 is composed of a driving chip, a first operational amplifier, a second operational amplifier, and an adjustable resistor, wherein the driving chip is connected to a unidirectional input terminal of the first operational amplifier, an output terminal of the first operational amplifier is connected to an inverting input terminal of the second operational amplifier, the adjustable resistor is connected to a power supply and the unidirectional input terminal of the second operational amplifier, and a driving signal is output from the output terminal of the second operational amplifier.
The host 02 is also internally provided with an electric field generation module, the electric field generation module is connected with the power module and comprises a composite pulse generation circuit and a booster circuit, the composite pulse generation circuit is used for generating composite pulses, preferably 3 groups of composite pulses, the rising edge and the falling edge of each composite pulse are both between 20-50 nanoseconds, so that the duration of a peak is long, a better treatment effect is achieved, and the booster circuit is used for converting the power voltage into the ultrahigh treatment voltage of plus and minus 3000V. The power module adopts a dual-power supply device which generates positive and negative voltages, and the dual-power supply device is used for providing positive and negative 220V working voltage for the circuit so as to ensure the normal operation of the circuit.
Referring to fig. 5, the structure of the composite pulse generating circuit is mainly: the anode of the power supply is connected with the collector of the switch tube S1 and the cathode of the diode D1, and the cathode of the power supply is connected with the anode of the diode D2 and the emitter of the switch tube S2; the emitter of the switch tube S1 is connected to the cathode of the diode D2 and the a terminal of the coupling inductor Lm, respectively, the anode of the diode D1 is connected to the collector of the switch tube S2 and the b terminal of the coupling inductor Lm, respectively, the collector of the switch tube S1 and the cathode of the diode D1 are connected to the positive electrode of the output terminal by a lead wire, and the c terminal of the coupling inductor Lm is connected to the negative electrode of the output terminal by a lead wire.
Referring to fig. 6, the boost circuit mainly includes a transformer T5, a voltage stabilizing circuit composed of a resistor R12, a diode D8, and a capacitor C10, a voltage stabilizing circuit composed of a resistor R13, a diode D9, and a capacitor C11, a filter circuit composed of a transformer T6, a capacitor C12, a capacitor C13, a capacitor C14, and a resistor R15, and a transformer T7. The power supply voltage can be output at 3000V.
It should be noted that the probe 03 provided in the embodiment of the present invention is connected to the probe 03 interface of the host 02, and only one of the electrical polarities of the probe 03 interface is negative, and the others are positive. Preferably, 6 probe 03 interfaces are provided, one negative and the other five positive. The probe 03 interface adopts a G8NW-2H-12VDC ohm dragon relay to realize the connection of the nanometer knife probe 03 and the circuit. The probe 03 of the embodiment is a disposable electrode needle, and the needle head of the probe 03 is coated with an insulating coating, so that the disposable electrode needle can prevent the probe 03 from being reused, and prevent tumor cells from being planted in normal cells. The insulating coating can avoid the accidental electric shock of a patient or a doctor.
In order to avoid electric shock of doctors, an isolation transformer is arranged on each probe 03 circuit in the prior art to prevent electric shock by mistake, but the design invisibly increases the cost of equipment. Therefore, the probes 03 of this embodiment are designed to have a negative five-positive structure, i.e., one of the probes 03 is connected to a negative voltage source, so that it is negatively charged. An isolation transformer is arranged in the probe 03 interface with negative polarity, when the circuit is connected, if the isolation transformer is not conducted, the circuit cannot form a passage, and the probe 03 head cannot be electrified, so that only one isolation transformer is needed, the electric shock can be prevented, and the cost can be saved. In addition, the output voltage value of each probe 03 has a different range, and the corresponding probe 03 needs to be selected according to the resistance value of the tumor cells during treatment.
The tumor ablation equipment using the ultrahigh-voltage positive-negative composite pulse electric field provided by the embodiment of the invention adopts a negative-five-positive probe 03 design, uses the ultrahigh-voltage positive-negative composite pulse to generate the electric field to achieve the purpose of ablating tumor cells, uses an infrared gesture control technology, is safe and sterile, ensures the operation environment of an operation, and improves the treatment efficiency.
Those skilled in the art will appreciate that the functionality described in the present invention may be implemented in a combination of hardware and software in one or more of the examples described above. When software is applied, the corresponding functionality may be stored on or transmitted over as one or more instructions or code on a computer-readable medium. Computer-readable media includes both computer storage media and communication media including any medium that facilitates transfer of a computer program from one place to another. A storage media may be any available media that can be accessed by a general purpose or special purpose computer.
The above-mentioned embodiments, objects, technical solutions and advantages of the present invention are further described in detail, it should be understood that the above-mentioned embodiments are only exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made on the basis of the technical solutions of the present invention should be included in the scope of the present invention.
Claims (8)
1. The utility model provides an application positive negative compound pulse electric field's of superhigh pressure tumour ablation equipment which characterized in that, tumour ablation equipment includes:
the interaction device comprises a data screen and an operation screen, wherein the data screen is used for displaying real-time data required by a surgery, the operation screen is used for displaying a real-time picture of a surgical scalpel part, and the operation screen is provided with a gesture control module;
the host computer is electrically connected with the interactive device and is used for collecting and processing real-time data required by the operation, generating a control instruction and controlling the internal circuit to generate an ultrahigh voltage positive and negative composite pulse electric field;
the probe is connected with a probe interface of the host, only one of the electric polarities of the probe interface is negative, and the rest of the electric polarities of the probe interface is positive, and the probe acts on the tumor cells.
2. The tumor ablation apparatus using ultra-high voltage positive-negative composite pulse electric field according to claim 1, wherein the gesture control module comprises:
an infrared emitter for emitting infrared rays to sense hand motion;
and the infrared receiver is used for receiving the infrared rays reflected by the hand and sending the received infrared rays to the host, and the host judges the corresponding gesture action according to the intensity of the infrared rays, matches a control instruction corresponding to the gesture action and controls related equipment to execute the control instruction.
3. The tumor ablation apparatus utilizing an ultra-high voltage positive-negative composite pulsed electric field as claimed in claim 1, wherein the host comprises a data acquisition unit, an electric field generation unit, a driving unit and a control unit, the data acquisition unit is used for acquiring real-time data and sending the real-time data to the control unit, the control unit is used for processing the real-time data and then generating a driving signal, the driving unit is used for triggering the electric field generation unit to generate the positive-negative composite pulsed electric field according to the driving signal, and the positive-negative composite pulsed electric field is released by the probe and acts on the tumor cells.
4. The tumor ablation device using the ultrahigh-voltage positive-negative composite pulse electric field according to claim 3, wherein the acquisition unit adopts a CPLD module, is electrically connected with an external device through an optical fiber interface circuit, and acquires the R waveform and the electrocardio trigger signal.
5. The tumor ablation device using the ultrahigh-voltage positive-negative composite pulsed electric field according to claim 3, wherein the control unit comprises a control chip and a communication module, the control chip adopts a single chip microcomputer, the control chip is electrically connected with the acquisition unit, and the communication module is used for the communication between the single chip microcomputer and an upper computer.
6. The tumor ablation apparatus with ultrahigh voltage positive-negative composite pulse electric field according to claim 3, wherein the driving unit comprises a driving chip, a first operational amplifier, a second operational amplifier and an adjustable resistor, the driving chip is connected to the homodromous input terminal of the first operational amplifier, the output terminal of the first operational amplifier is connected to the inverting input terminal of the second operational amplifier, the adjustable resistor is connected to the power supply and the homodromous input terminal of the second operational amplifier, and the output terminal of the second operational amplifier outputs the driving signal.
7. The tumor ablation apparatus using the ultra-high voltage positive-negative composite pulse electric field as claimed in claim 1, wherein the probe is a disposable electrode needle, and the needle head of the probe is coated with an insulating coating.
8. The tumor ablation apparatus with the ultrahigh voltage positive and negative composite pulse electric field as claimed in claim 1, wherein an isolation transformer is disposed in the probe interface with the negative electric polarity.
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Cited By (4)
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| CN113262040A (en) * | 2021-05-19 | 2021-08-17 | 北京金石翔宇科技有限公司 | Tumor ablation equipment using ultrahigh-voltage positive-negative composite pulse electric field |
| CN113274119A (en) * | 2021-05-19 | 2021-08-20 | 北京金石翔宇科技有限公司 | Tumor ablation equipment and method applying ultrahigh-voltage positive-negative composite pulse electric field |
| CN113855218A (en) * | 2021-09-26 | 2021-12-31 | 北京三春晖医疗器械有限公司 | Resistance evaluation tumor cell ablation system |
| CN114259291A (en) * | 2021-12-23 | 2022-04-01 | 心航路医学科技(广州)有限公司 | Control method and device of pulse ablation system |
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Application publication date: 20200623 |