CN113274119A - Tumor ablation equipment and method applying ultrahigh-voltage positive-negative composite pulse electric field - Google Patents
Tumor ablation equipment and method applying ultrahigh-voltage positive-negative composite pulse electric field Download PDFInfo
- Publication number
- CN113274119A CN113274119A CN202110548021.7A CN202110548021A CN113274119A CN 113274119 A CN113274119 A CN 113274119A CN 202110548021 A CN202110548021 A CN 202110548021A CN 113274119 A CN113274119 A CN 113274119A
- Authority
- CN
- China
- Prior art keywords
- resistor
- chip
- pin
- sampling
- capacitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00827—Current
Abstract
The invention discloses a tumor ablation device and method applying an ultrahigh-voltage positive-negative composite pulse electric field, and the tumor ablation device comprises a power module, a control module, a transmission circuit, an infrared recognition gesture control device and a sampling circuit; the control module receives signals of the infrared recognition gesture control device, the control module is respectively connected with the power supply module, the adoption circuit and the transmission circuit, and a main control chip of the control module is a chip STM32F103 VE; solves the problems that the existing tumor treatment equipment is easy to generate electric shock and inconvenient to operate, so that the treatment effect is not obvious.
Description
Technical Field
The invention relates to the field of tumor ablation, in particular to tumor ablation equipment and a tumor ablation method by using an ultrahigh-voltage positive-negative composite pulse electric field.
Background
Nanosecond pulsed electric fields are gaining increasing attention in the biomedical field with their unique "intracellular electric processing" effect. The intracellular electric treatment effect means that under the action of an external nanosecond pulse, a biological effect which is completely different from a microsecond pulse electroporation phenomenon appears in a cell, namely, the obvious electroporation phenomenon does not appear on the surface of a cell membrane, but a series of functional changes appear in the cell such as cell nucleus, mitochondria and the like to generate a large number of micronuclei and induce the programmed cell death, also called apoptosis. Because the tumor cells and the normal cells have different resistance values, the nanosecond pulse electric fields with different strengths are utilized to puncture the tumor cells in the clinical treatment of tumor diseases, the tumor cells can be killed without damaging the normal cells, and the treatment effect is good.
Therefore, tumor ablation devices have been developed, but the existing tumor ablation devices do not notice that tumor cells may change size along with the progress of treatment, so that the set breakdown current is insufficient or too large to hurt normal cells; in addition, in the treatment process by utilizing the prior art, the muscle tremor of the patient is serious, the psychological burden of the patient is increased, the treatment is not facilitated, and the treatment effect is greatly influenced when the electricity of the equipment is applied to the affairs of doctors and patients because the existing tumor ablation technology needs a large voltage to make tumor cells die.
The trigger signal is a square wave, one is a rising edge and the other is a falling edge, in actual operation, the equipment has time delay, and a certain time delay exists from the detected signal to discharging; the pulse discharge is triggered when the heart is in diastole, the discharge of the heart is caused in a diastole ending state, the instantaneous contraction of the heart is caused, and the heart pressure is increased; can advance 10ms through this patent, can realize triggering discharge under the best state of diastole, reduce the heart and bear the pressure. After the diastole action begins, the diastole is triggered when the diastole is maximum, and the injury is minimum.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides tumor ablation equipment using an ultrahigh-voltage positive-negative composite pulse electric field, and solves the problems that the existing tumor treatment equipment is easy to generate electric shock and is inconvenient to operate, so that the treatment effect is not obvious.
The invention provides a tumor ablation device applying an ultrahigh-voltage positive-negative composite pulse electric field, which comprises a power module, a control module, a transmission circuit, an infrared recognition gesture control device and a sampling circuit, wherein the power module is connected with the control module; the control module receives signals of the infrared recognition gesture control device, the control module is respectively connected with the power supply module, the adoption circuit and the transmission circuit, and a main control chip of the control module is a chip STM32F103 VE.
Preferably, the power supply module includes a chip AMS1086, a capacitor C2, a capacitor C5, a capacitor C10, and a capacitor C12; the 1 st pin of the chip AMS1086 is connected to the ground, the 2 nd pin of the chip AMS1086 is connected to the 4 th pin of the chip AMS1086, and the 3 rd pin of the chip AMS1086 is connected to the ground capacitor C5, the ground capacitors C2 and the 5V power supply respectively.
Preferably, the transmission circuit comprises a chip SP3485E, a resistor, a triode Q1, a voltage regulator tube D2, a voltage regulator tube D3, a capacitor C17, a capacitor C18 and a 5V power supply; the resistors comprise a resistor R9, a resistor R10, a resistor R11, a resistor R12, a resistor R13 and a resistor R14;
the 1 st pin of the chip SP3485E is connected with a resistor R12, the 2 nd pin of the chip SP3485E is respectively connected with the 3 rd pin of the chip SP3485E, the collector of the triode Q1 and one end of a resistor R10, the 4 th pin of the chip SP3485E is respectively connected with one end of a resistor R9 and one end of a resistor R11, the other end of the resistor R11 is connected with a 5V power supply,
the other end of the resistor R9 is connected with a 5V power supply, the emitter of the triode Q1 is connected with the ground, the 5 th pin of the chip SP3485E is connected with the ground, the 6 th pin of the chip SP3485E is connected with one end of the resistor R14, one end of the resistor R15, a grounded capacitor C18 and a grounded voltage regulator D3, and the 7 th pin of the chip SP3485E is respectively connected with the grounded resistor R13, the other end of the resistor R15, a grounded capacitor C17 and a grounded voltage regulator D2.
Preferably, the sampling circuit comprises an amplifier U1A, an amplifier U1B, and a current transformer TA 1; the 2 nd pin and the 4 th pin of the current transformer TA1 are both grounded, the 1 st pin of the current transformer TA1 is connected with the 3 rd pin of the amplifier U1A, the 2 nd pin of the chip U1A is connected with the 1 st pin of the chip U1A and one end of the resistor R3, the other end of the resistor R3 is connected with one end of the resistor R4 and the 5 th pin of the amplifier U1B, the other end of the resistor R4 is connected with the slide rheostat RV1, the 6 th pin of the amplifier U1B is connected with the 7 th pin of the amplifier U1B and one end of the resistor R5, and the other end of the resistor R5 is connected with the 26 th pin of the chip STM32F103 VE.
Preferably, the sampling method of the sampling circuit includes the steps of:
s1: starting to capture ADC of the 116-time chip STM32F103VE, firstly carrying out bubble sequencing on middle 50 groups of data in time sequence, and arranging the data from large to small;
s2: averaging 20 data in the middle of the sequence according to the magnitude to obtain a current pulse sampling value;
s3: calculating actual current after calibration according to the ratio of the internal ADC sampling value in the chip STM32F103VE to the actual current;
s4: the ADC sampling voltage in the chip STM32F103VE is 0-3.3V, and when the current is 0 without a signal, the PC1 needs to be adjusted to 1.65V by using RV 1;
s5: 100ma, 25.5 ohm theoretical sampling resistance, 3.30V + 2 voltage at PC3 of chip STM32F103VE, 3.3V maximum sampling voltage, and 64.7A maximum pulse current 3300/51.
Preferably, the step S2 includes the following sub-steps:
s21: establishing an analog value amplitude limiting self-adaptive sliding window, wherein the window width is the number of observable sampling data points and is set to be 20, the window height is +/-5 percent, and the window height is set to be the percentage of errors, so that analog value unreliable data rejected in different window intervals can be automatically adjusted, and the purpose of automatically adjusting the analog value window height is achieved;
step S22: the window slides. Searching for the change of the window sampling time between credible data spaces to synchronously move;
step S23: a trusted average is returned.
Preferably, the measurement method using the apparatus of claim 1 comprises the steps of:
s1: discharging positive pulses are arranged on an X axis, discharging negative pulses are arranged below the X axis, 3 positive pulses and 3 negative pulses are used for one-time discharging, 6 pulses are combined into a group, namely the interval of each pulse is 11ms, and the positive pulses and the negative pulses are 27.5 ms;
s2: the action time of the R wave is 10ms, the R wave is the diastole state of the heart, and the P wave is the contraction state of the heart.
Compared with the prior art, the invention has the beneficial effects that:
1. in the clinical treatment of tumor diseases, nanosecond pulsed electric fields with different intensities are utilized to puncture tumor cells, so that the tumor cells can be killed without damaging normal cells, and the treatment effect is good.
2. In the treatment process by utilizing the prior art, the muscle tremor of a patient is serious, the psychological burden of the patient is increased, the treatment is not facilitated, and the tumor cell apoptosis is caused by the large voltage required by the existing tumor ablation technology, so that the treatment effect is greatly influenced when the electricity of the equipment is transmitted to doctors and the patient.
Drawings
Fig. 1 is a general block diagram of the present invention.
Fig. 2 is a control block diagram of the present invention.
Fig. 3 is a sampling circuit diagram of the present invention.
Fig. 4 is a power supply block diagram of the present invention.
Fig. 5 is a waveform diagram of the present invention.
Fig. 6 is a waveform diagram of the present invention after improvement.
FIG. 7 is a normal electrocardiogram of the present invention.
FIG. 8(a) is an R-wave above the X-axis of the present invention;
FIG. 8(b) shows a P-wave of the present invention above the X-axis.
Detailed Description
The invention is further described with reference to the following drawings and detailed description.
The following description of the embodiments of the present invention is provided to facilitate the understanding of the present invention by those skilled in the art, but it should be understood that the present invention is not limited to the scope of the embodiments, and it will be apparent to those skilled in the art that various changes may be made without departing from the spirit and scope of the invention as defined and defined in the appended claims, and all matters produced by the invention using the inventive concept are protected.
As shown in fig. 1, a tumor ablation apparatus using an ultra-high voltage positive-negative composite pulse electric field comprises a power module, a control module, a transmission circuit, an infrared recognition gesture control device and a sampling circuit; the control module receives signals of the infrared recognition gesture control device, the control module is respectively connected with the power supply module, the adoption circuit and the transmission circuit, and as shown in fig. 2, a main control chip of the control module is a chip STM32F103 VE.
As shown in fig. 4, the power supply module includes a chip AMS1086, a capacitor C2, a capacitor C5, a capacitor C10, and a capacitor C12; the 1 st pin of the chip AMS1086 is connected to the ground, the 2 nd pin of the chip AMS1086 is connected to the 4 th pin of the chip AMS1086, and the 3 rd pin of the chip AMS1086 is connected to a ground capacitor C5, a ground capacitor C2 and a 5V power supply respectively.
The transmission circuit comprises a chip SP3485E, a resistor, a triode Q1, a voltage regulator tube D2, a voltage regulator tube D3, a capacitor C17, a capacitor C18 and a 5V power supply; the resistors comprise a resistor R9, a resistor R10, a resistor R11, a resistor R12, a resistor R13 and a resistor R14;
the 1 st pin of the chip SP3485E is connected with a resistor R12, the 2 nd pin of the chip SP3485E is respectively connected with the 3 rd pin of the chip SP3485E, the collector of the triode Q1 and one end of a resistor R10, the 4 th pin of the chip SP3485E is respectively connected with one end of a resistor R9 and one end of a resistor R11, the other end of the resistor R11 is connected with a 5V power supply,
the other end of the resistor R9 is connected with a 5V power supply, the emitter of the triode Q1 is connected with the ground, the 5 th pin of the chip SP3485E is connected with the ground, the 6 th pin of the chip SP3485E is connected with one end of the resistor R14, one end of the resistor R15, a grounding capacitor C18 and a grounding voltage regulator D3, and the 7 th pin of the chip SP3485E is respectively connected with the grounding resistor R13, the other end of the resistor R15, the grounding capacitor C17 and the grounding voltage regulator D2.
As shown in fig. 3, the sampling circuit includes an amplifier U1A, an amplifier U1B, and a current transformer TA 1; the 2 nd pin and the 4 th pin of the current transformer TA1 are both grounded, the 1 st pin of the current transformer TA1 is connected with the 3 rd pin of the amplifier U1A, the 2 nd pin of the chip U1A is connected with the 1 st pin of the chip U1A and one end of a resistor R3, the other end of the resistor R3 is connected with one end of a resistor R4 and the 5 th pin of the amplifier U1B respectively, the other end of the resistor R4 is connected with a slide rheostat RV1, the 6 th pin of the amplifier U1B is connected with the 7 th pin of the amplifier U1B and one end of the resistor R5 respectively, and the other end of the resistor R5 is connected with the 26 th pin of the chip STM32F103 VE.
The sampling method of the sampling circuit comprises the following steps:
s1: starting to capture ADC of the 116-time chip STM32F103VE, firstly carrying out bubble sequencing on middle 50 groups of data in time sequence, and arranging the data from large to small;
s2: averaging 20 data in the middle of the sequence according to the magnitude to obtain a current pulse sampling value;
s3: calculating actual current after calibration according to the ratio of the internal ADC sampling value in the chip STM32F103VE to the actual current;
s4: the ADC sampling voltage in the chip STM32F103VE is 0-3.3V, and when the current is 0 without a signal, the PC1 needs to be adjusted to 1.65V by using RV 1;
s5: 100ma, 25.5 ohm theoretical sampling resistance, 3.30V + 2 voltage at PC3 of chip STM32F103VE, 3.3V maximum sampling voltage, and 64.7A maximum pulse current 3300/51.
Step S2 of the present embodiment includes the following substeps:
s21: establishing an analog value amplitude limiting self-adaptive sliding window, wherein the window width is the number of observable sampling data points and is set to be 20, the window height is +/-5 percent, and the window height is set to be the percentage of errors, so that analog value unreliable data rejected in different window intervals can be automatically adjusted, and the purpose of automatically adjusting the analog value window height is achieved;
step S22: the window slides. Searching for the change of the window sampling time between credible data spaces to synchronously move;
step S23: a trusted average is returned.
In this embodiment, a common method for taking an average value includes: 1. an amplitude limiting filtering method (after removing an abnormal value of which the amplitude exceeds the limit, the rest part is averaged); 2. median filtering (sorting all data by bubbling method, taking median as average); 3. arithmetic mean method (arithmetic mean is done for all or a middle part of samples for signal fluctuations around a certain range of values).
For the analog values of the entire 116 ADCs, the data in the middle may also deviate from the actual values due to signal interference due to spikes and dips that may occur during the early and late sampling periods. The data at the middle position cannot be determined to be real credible data by sequencing from the minimum value to the maximum value, so that the average value of a certain interval is taken only, and the real average value of the signal cannot be really reflected. The reason for this is that: the sorted data may be distributed anywhere across the 1-116 data spaces, ignoring the temporal location where the sample values occur.
The invention provides an analog value amplitude limiting self-adaptive sliding window method which comprises the steps of firstly searching a credible space of data, taking an interval with the most uniform data distribution as a credible data interval, and then carrying out arithmetic mean on credible data in the credible data interval.
The first step is as follows: and establishing a sliding window of the analog value amplitude limiting self-adaption. The window width is the observable sampling data point number, is set to be 20, the window height is +/-5%, the window height is set to be the percentage of error, the analog value unreliable data rejected in different window intervals can be automatically adjusted, and the purpose of automatically adjusting the analog value window height is achieved.
The second step is that: the window slides. Searching for the change of the window sampling time between credible data spaces to synchronously move;
the third step: a trusted average is returned.
In this embodiment, the window initially stays between the 1 st and 20 th data,
1) setting i to be 0;
2) sampling analog values from ADC (i) to ADC (i +19), and storing the analog values into a buffer array ADC [20 ];
3) calculating the arithmetic mean of all data in ADC [20 ];
4) and comparing the difference values of all 20 data with the average value, and solving the error percentage of each data relative to the average value of the current window, wherein if more than +/-5% of data appears, the current window is an untrusted window. If all the data fall into the trusted window, jumping to step 6), otherwise executing step 5);
5) returning to 1) and continuing to repeat the steps of 2-4 above with i + 1;
6) the current average value is returned.
The measurement method of the present embodiment to which the apparatus of claim 1 is applied comprises the steps of:
s1: discharging positive pulses are arranged on an X axis, discharging negative pulses are arranged below the X axis, 3 positive pulses and 3 negative pulses are used for one-time discharging, 6 pulses are combined into a group, namely the interval of each pulse is 11ms, and the positive pulses and the negative pulses are 27.5 ms;
s2: the action time of the R wave is 10ms, the R wave is the diastole state of the heart, and the P wave is the contraction state of the heart.
In the implementation of the present embodiment, a dead-beat prediction control strategy is adopted to find the R wave in advance, and the following examples are given:
if the waveform of electrocardiogram is f (t), then
At t ═ t0The Taylor series expansion for the time can be
f(t)＝f(t0)+Δtf'(t0)+…
Neglecting more than a second order error term
f(t+Δt)＝f(t)+Δtf'(t)
f(t1)＝f(t0)+Δtf'(t0)
Measured f (t)0),f(t1),f(t2)，
Measurement of
Get K3＝2K2-K1Then f' (t) is predicted3)＝f(t2)+Δt·K3And the measured value f (t)3) Comparison
If f (t)3)＞f'(t3) And still in an acceleration ascending trend, otherwise, entering a deceleration stage.
After entering the deceleration stage, continuously predicting n steps to form a cycle, and simultaneously comparing predicted values f (n) and f (n-1)
K'4＝2K3-K2
K′5＝2K'4-K3
K'6＝2K′5-K4
K'n＝2K'n-1-Kn-2
f'(t4)＝f(t3)+Δt·K'4
f'(t5)＝f(t4)+Δt·K′5
f'(t6)＝f(t3)+Δt·K'6
f'(n)＝f(n-1)+Δt·f'(n)
If f (n) is less than f (n-1), finding an inflection point n steps ahead, and recording the amplitude as P1Similarly, the inflection point P of the second waveform is found2Comparison of P1And P2The amplitude is high and is R wave, otherwise, P wave. The time points of occurrence of the R-wave and the P-wave were recorded as T (R1) and T (P1), respectively.
Repeating the method to find time points of occurrence of the second R wave and the second P wave, T (R2) and T (P2);
estimating the peak time of the next occurrence of the R wave by using T (R1) and T (R2);
and starting to emit high-voltage positive and negative pulse electric fields 10ms before the next R wave peak value appears.
In the implementation of the embodiment, the design of the ultrahigh voltage positive and negative composite pulse electric field generation circuit
Positive and negative compound pulse electric field of superhigh pressure generates circuit relates to high-voltage pulse treatment field, and the circuit includes: the power supply module is used for providing positive and negative power supplies, the electric field generation module is used for increasing the power supply voltage to 3000V so as to provide positive and negative 3000V bipolar voltage and reduce muscle tremor, the interface circuit is connected with external detection equipment, the control module is used for collecting and processing real-time data, and a driving signal is generated to drive the electric field generation module to operate. Can solve the problems of inaccurate tumor cell treatment and serious muscle tremor in the prior tumor treatment technology, and further improves the treatment efficiency of the tumor cells.
Characteristic of the technology
Positive negative compound pulse electric field of superhigh pressure generates circuit, the circuit includes:
a power supply module: the power supply module is used for providing positive and negative working voltages for the circuit;
an electric field generation module: the electric field generation module is connected with the power supply module, is used for converting power supply voltage into ultra-high voltage treatment voltage and providing positive and negative composite pulses, and the output end of the electric field generation module is provided with a plurality of probe interfaces;
a drive circuit: the driving circuit is connected with the electric field generation module and used for receiving a driving signal and driving the electric field generation module to work according to the driving signal;
a control module: the control module is connected with the drive circuit and used for generating a drive signal according to clinical data so as to control the drive circuit to work;
an interface circuit: the interface circuit is connected with the control module and used for receiving clinical data and sending the clinical data to the control module.
The infrared emitter is used for emitting infrared rays;
the infrared receiver is used for receiving the infrared rays reflected by the hand;
the memory is used for storing one or more program instructions;
a processor for executing one or more program instructions to perform the method of any of the above.
9) A computer readable storage medium having one or more program instructions embodied therein for use by an infrared recognition gesture control system in performing any of the methods described above.
Tumor ablation equipment applying ultrahigh-voltage positive-negative composite pulse electric field
Functional requirements
Tumor ablation equipment using an ultrahigh-pressure positive-negative composite pulse electric field relates to the field of tumor treatment equipment, and comprises: the interaction device sends out a control instruction through gesture control; the host is electrically connected with the interactive device and used for acquiring and processing real-time data required by the operation to generate a control instruction and controlling the internal circuit to generate an ultrahigh voltage positive and negative composite pulse electric field; the probe is connected with a probe interface of the host, only one of the electric polarities of the probe interface is negative, the rest of the electric polarities of the probe interface is positive, and the probe acts on the tumor cells. This equipment can solve current tumour treatment equipment and easily take place to electrocute, and the inconvenient problem that leads to treatment effect obscure of operation. The design of a probe with one negative electrode, five positive electrodes and an infrared gesture control technology is adopted, safety and sterility are achieved, the operation environment of an operation is guaranteed, and the treatment efficiency is improved.
Characteristic of the technology
The tumor ablation equipment using the ultrahigh-voltage positive-negative composite pulse electric field comprises the following units and characteristics:
the interaction device comprises a data screen and an operation screen, wherein the data screen is used for displaying real-time data required by the operation, the operation screen is used for displaying a real-time picture of a surgical scalpel part, and the operation screen is provided with a gesture control module;
the host is electrically connected with the interactive device and used for collecting and processing real-time data required by the operation, generating a control instruction and controlling an internal circuit to generate an ultrahigh voltage positive and negative composite pulse electric field;
the probe is connected with a probe interface of the host, only one of the electric polarities of the probe interface is negative, and the rest electric polarities of the probe interface are positive, and the probe acts on the tumor cells.
System components and structures
System components
The standard configuration is shown in Table 1
TABLE 1
| Serial number | Name of accessory | Number of | Remarks for |
| 1 | Main unit (Generator) | 1 table | |
| 2 | Operation table | 1 is provided with | |
| 3 | |
2 table | |
| 4 | Power |
1 is provided with | |
| 5 | |
1 is provided with | |
| 6 | Disposable |
6 are | |
| 7 | |
1 is provided with | |
| 8 | Operation software of composite pulse electric field |
1 set of | |
| 9 | Computer planning treatment software of composite pulse electric field |
1 set of | |
| 10 | User manual of composite pulse electric field |
1 |
|
| 11 | |
1 set of |
The system accessories comprise a power cable, a grounding wire, communication cables of all subsystems, an external wire or pipe fixing plate and an electrocardiograph
System architecture
The composite pulsed electric field tumor ablation system utilizes disposable electrodes to deliver energy from a generator to an ablation target. The structure comprises the following steps: LCD display, control panel and keyboard, power supply unit and power cord double-triggering foot switch/foot pedal, electrocardiograph.
As shown in fig. 3, R1 and R2 sample resistors, UIA voltage followers (also called emitter followers, which act as buffers, isolators, and improves the carrying capacity). UIB DC bias (changing AC signal to 0-5V signal), changing resistance of RV1 can change the position of 0 potential, and R3, R4, R5 current-limiting resistors.
The pulse width is 100us, the sampling precision of the single chip microcomputer STM32F429VET6 is 12-bit sampling rate 1.1667M, effective sampling within a pulse width 100us period is 116 times, the single chip microcomputer starts ADC sampling when OPT2 is a trigger signal, the ADC sampling is started to capture 116 times, 50 groups of data in the middle of time sequence are firstly subjected to bubbling sequencing, and the data are arranged from large to small. And averaging the middle 20 data according to the size sequence to obtain the current pulse sampling value. And calculating and calibrating the actual current according to the ratio of the ADC sampling value to the actual current.
ADC sampling voltage in the single chip microcomputer is 0-3.3V, and when current is 0 without a signal, the PC1 needs to be adjusted to 1.65V by RV 1.
TAK17-05, high-frequency pulse current transformer 50A:100ma, and theoretical sampling resistance of 25.5 ohm. The voltage at PC3 ═ 3.30V + sample voltage)/2. The maximum sampling voltage is 3.3V, and the maximum pulse current 3300/51 is 64.7A.
By applying the device, the device in the United states, namely the prior art, is single pulse 6 pulses, the action time is 66ms, and the device adopts positive and negative pulses 6 pulses, and the action time is 27.5 ms.
As shown in FIG. 5, positive discharge pulses are on the X-axis, negative discharge pulses are below the X-axis, 3 positive pulses and 3 negative pulses are used for one discharge, 6 pulses are in a group, the device has higher efficiency and shorter action time than the device in the United states, the interval of each pulse is 11ms, and the interval of the positive pulse and the negative pulse is 27.5ms
As shown in fig. 6, now a further 10ms in advance of the action time of the R-wave,
as shown in fig. 7, the working principle of the heart: (verification) the R-wave is the diastolic state of the heart and the P-wave is the systolic state of the heart.
As shown in fig. 8, the shorter the time during which the discharge pulse acts in the diastolic state is in synchronization with the R-wave, the smaller the pressure on the heart is, and the smaller the influence on other organs of the human body is.
Problems with current devices:
ECG monitor
From the detection of the heart beating to the display output, a certain time delay exists and cannot be eliminated; 2 groups of signals, namely R wave signals and trigger signals, are output by the ECG monitor; the discharging device is only effective to the falling edge of the trigger signal, the time from the R wave to the P wave is about 200ms (according to different patients, the time is different), so that the damage of the discharging pulse to the human body is minimum, and the time delay from the ECG monitor to the discharging device is eliminated as much as possible.
The improved discharge control strategy carries out reverse processing on the monitored rising edge of the trigger signal, and meanwhile, the trigger signal is transmitted through the optical fiber, so that the delay time of the discharge equipment is eliminated. Thus, the initial discharge time is advanced by 10 ms.
In addition, the pulse voltage potential is lifted, the reason is that positive and negative signals are output by the mutual inductor, the single chip microcomputer only recognizes the positive signals, the signals are lifted through the potentiometer and the adder, and the signals are conveniently collected and processed by the single chip microcomputer.
Claims (7)
1. A tumor ablation device applying an ultrahigh-voltage positive-negative composite pulse electric field is characterized by comprising a power supply module, a control module, a transmission circuit, an infrared recognition gesture control device and a sampling circuit; control module receives infrared recognition gesture controlling means's signal, control module connects power module, adopts circuit and transmission circuit respectively, control module's main control chip is chip STM32F103 VE.
2. The tumor ablation device applying the ultrahigh-voltage positive-negative composite pulsed electric field according to claim 1, wherein the power supply module comprises a chip AMS1086, a capacitor C2, a capacitor C5, a capacitor C10 and a capacitor C12; the 1 st pin of the chip AMS1086 is connected to the ground, the 2 nd pin of the chip AMS1086 is connected to the 4 th pin of the chip AMS1086, and the 3 rd pin of the chip AMS1086 is respectively connected to a ground capacitor C5, a ground capacitor C2 and a 5V power supply.
3. The tumor ablation apparatus applying the ultrahigh-voltage positive-negative composite pulse electric field according to claim 1, wherein the transmission circuit comprises a chip SP3485E, a resistor, a triode Q1, a voltage regulator tube D2, a voltage regulator tube D3, a capacitor C17, a capacitor C18 and a 5V power supply; the resistors comprise a resistor R9, a resistor R10, a resistor R11, a resistor R12, a resistor R13 and a resistor R14;
a1 st pin of the chip SP3485E is connected to the resistor R12, a 2 nd pin of the chip SP3485E is connected to a 3 rd pin of the chip SP3485E, a collector of the triode Q1 and one end of the resistor R10, a 4 th pin of the chip SP3485E is connected to one end of the resistor R9 and one end of the resistor R11, the other end of the resistor R11 is connected to the 5V power supply, the other end of the resistor R9 is connected to the 5V power supply, an emitter of the triode Q1 is connected to ground, a 5 th pin of the chip SP3485E is connected to ground, a 6 th pin of the chip SP3485E is connected to one end of the resistor R14, one end of the resistor R15, the ground capacitor C18 and the ground regulator D3, and a 7 th pin of the chip SP3485E is connected to the ground resistor R13, the other end of the resistor R15, the ground capacitor C17 and the ground regulator D2.
4. The tumor ablation apparatus applying the ultrahigh-voltage positive-negative composite pulsed electric field according to claim 1, wherein the sampling circuit comprises an amplifier U1A, an amplifier U1B and a current transformer TA 1; the 2 nd pin and the 4 th pin of the current transformer TA1 are both grounded, the 1 st pin of the current transformer TA1 is connected with the 3 rd pin of the amplifier U1A, the 2 nd pin of the chip U1A is connected with the 1 st pin of the chip U1A and one end of a resistor R3, the other end of the resistor R3 is connected with one end of a resistor R4 and the 5 th pin of the amplifier U1B, the other end of the resistor R4 is connected with a slide rheostat RV1, the 6 th pin of the amplifier U1B is connected with the 7 th pin of the amplifier U1B and one end of a resistor R5, and the other end of the resistor R5 is connected with the 26 th pin of the chip STM32F103 VE.
5. The tumor ablation device using the ultrahigh-voltage positive-negative composite pulse electric field as claimed in claim 4, wherein the sampling method of the sampling circuit comprises the following steps:
s1: starting to capture ADC of the 116-time chip STM32F103VE, firstly carrying out bubble sequencing on middle 50 groups of data in time sequence, and arranging the data from large to small;
s2: averaging 20 data in the middle of the sequence according to the magnitude to obtain a current pulse sampling value;
s3: calculating actual current after calibration according to the ratio of the internal ADC sampling value in the chip STM32F103VE to the actual current;
s4: the ADC sampling voltage in the chip STM32F103VE is 0-3.3V, and when the current is 0 without a signal, the PC1 needs to be adjusted to 1.65V by using RV 1;
s5: 100ma, 25.5 ohm theoretical sampling resistance, 3.30V + 2 voltage at PC3 of chip STM32F103VE, 3.3V maximum sampling voltage, and 64.7A maximum pulse current 3300/51.
6. The tumor ablation apparatus using ultra-high voltage positive-negative composite pulse electric field according to claim 5, wherein the sampling method of the sampling circuit comprises the following sub-steps:
s21: establishing an analog value amplitude limiting self-adaptive sliding window, wherein the width of the window is the number of observable sampling data points and is set to be 20, the height of the window is +/-5 percent, and the height of the window is set to be the percentage of an error, so that analog value unreliable data rejected in different window intervals can be automatically adjusted, and the purpose of automatically adjusting the height of the analog value window is achieved;
step S22: the window slides. Searching for the change of the window sampling time between credible data spaces to synchronously move;
step S23: a trusted average is returned.
7. A measuring method using the apparatus of claim 1, comprising the steps of:
s1: discharging positive pulses are arranged on an X axis, discharging negative pulses are arranged below the X axis, 3 positive pulses and 3 negative pulses are used for one-time discharging, 6 pulses are combined into a group, namely the interval of each pulse is 11ms, and the positive pulses and the negative pulses are 27.5 ms;
s2: the action time of the R wave is further increased by 10ms, the R wave is in a diastolic state of the heart, and the P wave is in a systolic state of the heart, so that an output result is obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110548021.7A CN113274119A (en) | 2021-05-19 | 2021-05-19 | Tumor ablation equipment and method applying ultrahigh-voltage positive-negative composite pulse electric field |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110548021.7A CN113274119A (en) | 2021-05-19 | 2021-05-19 | Tumor ablation equipment and method applying ultrahigh-voltage positive-negative composite pulse electric field |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113274119A true CN113274119A (en) | 2021-08-20 |
Family
ID=77280061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110548021.7A Pending CN113274119A (en) | 2021-05-19 | 2021-05-19 | Tumor ablation equipment and method applying ultrahigh-voltage positive-negative composite pulse electric field |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113274119A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113838556A (en) * | 2021-09-24 | 2021-12-24 | 北京三春晖医疗器械有限公司 | Composite pulse electric field tumor ablation planning system |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103479347A (en) * | 2012-06-13 | 2014-01-01 | 韦伯斯特生物官能(以色列)有限公司 | Gated sampling of electrocardiogram signals during ablation waveform zero-crossing |
| CN106725451A (en) * | 2016-12-30 | 2017-05-31 | 天津市鹰泰利安康医疗科技有限责任公司 | A kind of human body electrocardio R ripple detecting systems |
| CN107569226A (en) * | 2017-09-27 | 2018-01-12 | 广州中科新知科技有限公司 | HRV method and application is obtained based on piezoelectric sensing |
| CN107582166A (en) * | 2017-10-12 | 2018-01-16 | 天津市鹰泰利安康医疗科技有限责任公司 | A kind of ECG Synchronization system for the ablation of high pressure steep-sided pulse |
| CN108596132A (en) * | 2018-04-28 | 2018-09-28 | 上海微创电生理医疗科技股份有限公司 | Ablation stove evaluation method and system |
| CN111317559A (en) * | 2020-03-12 | 2020-06-23 | 北京三春晖医疗器械有限公司 | Ultrahigh-voltage positive-negative composite pulse electric field generation circuit |
| CN111317558A (en) * | 2020-03-12 | 2020-06-23 | 北京三春晖医疗器械有限公司 | Tumor ablation equipment using ultrahigh-voltage positive-negative composite pulse electric field |
| WO2021023129A1 (en) * | 2019-08-06 | 2021-02-11 | 深圳钮迈科技有限公司 | Real-time pulse monitoring circuit and tumor treatment apparatus |
-
2021
- 2021-05-19 CN CN202110548021.7A patent/CN113274119A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103479347A (en) * | 2012-06-13 | 2014-01-01 | 韦伯斯特生物官能(以色列)有限公司 | Gated sampling of electrocardiogram signals during ablation waveform zero-crossing |
| CN106725451A (en) * | 2016-12-30 | 2017-05-31 | 天津市鹰泰利安康医疗科技有限责任公司 | A kind of human body electrocardio R ripple detecting systems |
| CN107569226A (en) * | 2017-09-27 | 2018-01-12 | 广州中科新知科技有限公司 | HRV method and application is obtained based on piezoelectric sensing |
| CN107582166A (en) * | 2017-10-12 | 2018-01-16 | 天津市鹰泰利安康医疗科技有限责任公司 | A kind of ECG Synchronization system for the ablation of high pressure steep-sided pulse |
| CN108596132A (en) * | 2018-04-28 | 2018-09-28 | 上海微创电生理医疗科技股份有限公司 | Ablation stove evaluation method and system |
| WO2021023129A1 (en) * | 2019-08-06 | 2021-02-11 | 深圳钮迈科技有限公司 | Real-time pulse monitoring circuit and tumor treatment apparatus |
| CN111317559A (en) * | 2020-03-12 | 2020-06-23 | 北京三春晖医疗器械有限公司 | Ultrahigh-voltage positive-negative composite pulse electric field generation circuit |
| CN111317558A (en) * | 2020-03-12 | 2020-06-23 | 北京三春晖医疗器械有限公司 | Tumor ablation equipment using ultrahigh-voltage positive-negative composite pulse electric field |
Non-Patent Citations (2)
| Title |
|---|
| 网络整理: "sp3485通信自动收发电路 - sp3485推荐电路（几款收发芯片sp3485电路） - IC应用电路图 - 电子发烧友网", 《HTTPS://M.ELECFANS.COM/ARTICLE/617635.HTML》 * |
| 黄健等: "基于STM32的A/D采样软件滤波改进算法研究", 《仪表技术与传感器》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113838556A (en) * | 2021-09-24 | 2021-12-24 | 北京三春晖医疗器械有限公司 | Composite pulse electric field tumor ablation planning system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104173043B (en) | Electrocardiogram (ECG) data analysis method suitable for mobile platform | |
| JP6200590B2 (en) | System and method for generating an electrophysiological map | |
| US6505079B1 (en) | Electrical stimulation of tissue for therapeutic and diagnostic purposes | |
| JPH01110345A (en) | Apparatus and method for detecting heart character by electric stimulation | |
| CN114469308B (en) | Pulsed electric field ablation system | |
| CN107847174B (en) | Pace-making signal processing method and system and electrocardiogram monitor | |
| CN111317558A (en) | Tumor ablation equipment using ultrahigh-voltage positive-negative composite pulse electric field | |
| US7047067B2 (en) | Apparatus, methods, and computer program products for evaluating a risk of cardiac arrhythmias from restitution properties | |
| CN114271931A (en) | Pulse ablation system | |
| CN113262040A (en) | Tumor ablation equipment using ultrahigh-voltage positive-negative composite pulse electric field | |
| CN113274119A (en) | Tumor ablation equipment and method applying ultrahigh-voltage positive-negative composite pulse electric field | |
| CN217162274U (en) | Pulse electric field generator | |
| CN111317559A (en) | Ultrahigh-voltage positive-negative composite pulse electric field generation circuit | |
| CN114259296A (en) | Pulse electric field generator | |
| Valais et al. | Design and construction of a prototype ECG simulator | |
| CN113017821A (en) | Cardiac pacing and irreversible electroporation (IRE) combination therapy | |
| CN103169466A (en) | Algesia monitoring system and monitoring method for anesthesia | |
| CN107995854A (en) | The non-intrusion type assessment of cardiac resynchronization therapy | |
| JPH08322950A (en) | Apparatus for detecting stimulated active electric current of heart | |
| JP2022532843A (en) | Systems and methods for cardiac mapping | |
| CN105268104B (en) | Transcranial magnetic stimulation instrument system for controlling stimulation coil end | |
| CN111437509B (en) | Functional electric stimulation device for hand reflex zone and control method | |
| CN114796870A (en) | External counterpulsation instrument | |
| CN204158893U (en) | A kind of transcranial magnetic stimulation instrument controlling stimulating coil end | |
| CN216962609U (en) | Pulse ablation system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210820 |
|
| RJ01 | Rejection of invention patent application after publication |