CN113838556A

CN113838556A - Composite pulse electric field tumor ablation planning system

Info

Publication number: CN113838556A
Application number: CN202111123637.6A
Authority: CN
Inventors: 孔显娟; 王国经
Original assignee: Beijing Sanchunhui Medical Equipment Co ltd
Current assignee: Beijing Jiumenchun Medical Technology Co ltd
Priority date: 2021-09-24
Filing date: 2021-09-24
Publication date: 2021-12-24

Abstract

The embodiment of the application discloses a composite pulse electric field tumor ablation planning system, which is used for managing all patient information through a database by a case management module; the registration fusion module is used for spatially aligning the image sequences of the cases of the image sequences and spatially transforming the sequence to be registered to the corresponding position of the reference sequence; the contour delineation module is used for delineating important visceral organs, focus target areas and evasion organs of a patient on an image sequence of the patient and carrying out three-dimensional reconstruction; the operation planning module is used for arranging, adjusting and managing needle paths, simulating an action field and an ablation process and determining treatment parameters; the intraoperative monitoring module is used for importing an intraoperative image sequence, acquiring an initial tumor resistance value and a final resistance value after ablation according to the probe and monitoring the operation process; and the operation report module is used for displaying and managing the preoperative planning scheme and the treatment report. Can efficiently and conveniently assist the compound pulse electric field tumor ablation operation.

Description

Composite pulse electric field tumor ablation planning system

Technical Field

The embodiment of the application relates to the technical field of medical treatment, in particular to a composite pulse electric field tumor ablation planning system.

Background

At present, the tumor treatment means is mainly surgical operation, and radiotherapy and chemotherapy are carried out secondly. Wherein, the operation treatment takes long time, the blood loss is large, the open operation infection chance is large, and the treatment cost is high; part of patients are insensitive to radiotherapy, and radiotherapy has more side effects; most tumors are usually insensitive to chemotherapy and have significant systemic side effects. In order to solve the above problems, attempts have been made at home and abroad to overcome the side effects of the above three treatments by using ablation treatments such as microwave, radio frequency, laser, etc.

Ablation therapy refers to the effect of surgical excision by directly causing coagulation necrosis of tissues in a treatment area through high temperature or ultralow temperature. Among them, the main advantages of ablation therapy are: the operation is not needed, one-time or multiple-time conformal treatment can be adopted, the postoperative recovery is fast, the total treatment cost is low, and simultaneously, the immune system can be activated; the medicine has no radiation and chemical injury, does not cause the problem of insensitivity of tumors in radiotherapy and chemotherapy, can be repeatedly treated, and can also implement planned segmented treatment; the early-stage lesion can be treated radically, and the late-stage lesion can be treated palliatively, so that the tumor load is effectively reduced. Meanwhile, the traditional Chinese medicine composition can be matched with other treatment means such as radiotherapy, chemotherapy and the like, and does not conflict with other treatment methods.

A system is needed to assist in the entire course of a tumor ablation procedure before and after ablation treatment.

Disclosure of Invention

Therefore, the embodiment of the application provides a combined pulse electric field tumor ablation planning system which can assist the combined pulse electric field tumor ablation operation efficiently and conveniently.

In order to achieve the above object, the embodiments of the present application provide the following technical solutions:

a composite pulsed electric field tumor ablation planning system, the system comprising:

the case management module is used for managing all patient information through a database, wherein the patient information comprises basic patient information, image sequences, registration, contours and operation plans;

the registration fusion module is used for spatially aligning the image sequences of the cases of the image sequences and spatially transforming the sequence to be registered to the corresponding position of the reference sequence;

the contour delineation module is used for delineating important visceral organs, focus target areas and evasion organs of a patient on an image sequence of the patient and carrying out three-dimensional reconstruction;

the operation planning module is used for arranging, adjusting and managing needle paths, simulating an action field and an ablation process and determining treatment parameters;

the intraoperative monitoring module is used for importing an intraoperative image sequence, acquiring an initial tumor resistance value and a final resistance value after ablation according to the probe and monitoring the operation process;

and the operation report module is used for displaying and managing the preoperative planning scheme and the treatment report.

Optionally, the case management module includes:

the system comprises a case creation module, a case creation module and a case display module, wherein the case creation module is used for creating a case by reading a DICOM (digital imaging and communications in medicine) format image sequence of a patient in multiple modes;

the case saving and reading module is used for loading the case data saved locally and automatically jumping to a preoperative planning function, reading the image data and the surgical planning data, and saving all data of the case, wherein the case information and the local storage path are uploaded to the database;

a case editing module for modifying case data other than the case creation time, the editing time, and the number of series;

the case retrieval module is used for retrieving cases meeting the field conditions according to the retrieval fields input by the user and displaying the cases in a patient list in the middle of a case management interface; the system is also used for retrieving a case with case editing time in the time slot according to the retrieval time slot input by the user;

and the sequence management module is used for adding or deleting the sequence by the user and also used for adding the patient image sequence.

Optionally, the registration fusion module includes:

the registration module is used for adding registration pairs of a plurality of image sequences and adjusting a visual display mode;

the manual registration module is used for aligning the spatial positions of the image sequences through dragging and rotating operations by an operator on a software interface;

the automatic rigid body registration module is used for aligning the image to be registered with the reference image at a spatial position by utilizing rotation and translation operations in image application;

the automatic deformation registration module is used for carrying out translation, rotation and deformation on the image;

the registration effect checking module is used for adjusting the display effect to the standard by adjusting the fusion proportion and the window width and window level;

the registration pair resetting module is used for restoring the image sequences to the original positions;

and the deleting registration pair module is used for deleting the target registration pair.

Optionally, the contouring module includes:

the contour adding module is used for adding contours based on contour colors, contour types, two-dimensional display modes and three-dimensional display modes of the contours and rendering parameters of the three-dimensional model selected by a user;

the manual drawing outline module is used for correcting the drawing and the outline of the focus target area through the drawing brush and/or the intelligent drawing brush;

the semi-automatic contour delineating module is used for carrying out operations of threshold segmentation and region growth;

the automatic contour delineating module is used for automatically segmenting skin, bones, liver and blood vessels;

the outline zooming module is used for amplifying or reducing the outlined outline;

the contour interpolation module is used for automatically and linearly inserting contour lines of the middle layer;

a contour mapping module, which is used for converting the target area or organ delineated on a certain sequence to another sequence through the registration relation so as to view or perform operation planning on the other sequence;

and the contour line deleting and deleting module is used for deleting the contour in the current case and/or clearing the contour data of the current image.

Optionally, the surgical planning module is to:

the operation plan management module is used for adding and/or deleting an operation plan;

the needle channel arrangement module is used for adding needle channels and automatically arranging needles according to the position, shape and size of a target area, the main needles and the auxiliary needles are matched for use, and the number of the auxiliary needles is set according to the shape and size of an ablation target area;

the needle channel deleting module is used for deleting the needle channel;

the safety inspection module is used for assisting in judging whether the puncture path touches organs and tissues to be avoided or not by the needle path safety detection function and prompting;

and the action field simulation module is used for checking the action field distribution simulation results near different needle channels in the treatment process after finishing the needle channel arrangement and before treatment so as to assist in formulating reasonable treatment parameters.

Optionally, the intraoperative monitoring module includes:

the plan optimization module is used for adjusting and optimizing a plan needle path according to the actual needle path;

and the dynamic ablation module is used for monitoring the ablation process in real time by using ablation instrument hardware.

Optionally, the surgical reporting module includes:

the operation report management module is used for automatically generating an operation report according to the operation plan and automatically adding case information and needle path information;

the screenshot management module is used for adding screenshots into the operation report;

and the browsing and printing module is used for browsing, exporting, storing and printing the operation report.

In summary, the embodiment of the present application provides a composite pulse electric field tumor ablation planning system, which is configured to manage all patient information through a database by a case management module, where the patient information includes patient basic information, an image sequence, registration, contour and a surgical plan; the registration fusion module is used for spatially aligning the image sequences of the cases of the image sequences and spatially transforming the sequence to be registered to the corresponding position of the reference sequence; the contour delineation module is used for delineating important visceral organs, focus target areas and evasion organs of a patient on an image sequence of the patient and carrying out three-dimensional reconstruction; the operation planning module is used for arranging, adjusting and managing needle paths, simulating an action field and an ablation process and determining treatment parameters; the intraoperative monitoring module is used for importing an intraoperative image sequence, acquiring an initial tumor resistance value and a final resistance value after ablation according to the probe and monitoring the operation process; and the operation report module is used for displaying and managing the preoperative planning scheme and the treatment report. Can efficiently and conveniently assist the compound pulse electric field tumor ablation operation.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It should be apparent that the drawings in the following description are merely exemplary, and that other embodiments can be derived from the drawings provided by those of ordinary skill in the art without inventive effort.

The structures, ratios, sizes, and the like shown in the present specification are only used for matching with the contents disclosed in the specification, so that those skilled in the art can understand and read the present invention, and do not limit the conditions for implementing the present invention, so that the present invention has no technical significance, and any structural modifications, changes in the ratio relationship, or adjustments of the sizes, without affecting the functions and purposes of the present invention, should still fall within the scope of the present invention.

Fig. 1 is a block diagram of a composite pulsed electric field tumor ablation planning system according to an embodiment of the present disclosure.

Detailed Description

The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Fig. 1 illustrates a composite pulsed electric field tumor ablation planning system provided by an embodiment of the present application, the system including:

a case management module 101 for managing all patient information including patient basic information, image sequences, registration, contours, and surgical plans through a database;

a registration fusion module 102, configured to spatially align image sequences of cases of a plurality of image sequences, and spatially transform a sequence to be registered to a corresponding position of a reference sequence;

the contour delineation module 103 is used for delineating important visceral organs, focus target areas and avoidance organs of a patient on an image sequence of the patient and reconstructing the images in three dimensions;

a surgical planning module 104 for needle track arrangement, adjustment and management, and for action field and ablation process simulation and determination of treatment parameters;

the intraoperative monitoring module 105 is used for importing an intraoperative image sequence, acquiring an initial tumor resistance value and a final resistance value after ablation according to the probe, and monitoring the operation process;

a surgical reporting module 106 for displaying and managing the preoperative planning plan and treatment reports.

In one possible embodiment, the case management module 101 includes:

In a possible implementation, the registration fusion module 102 includes:

In a possible implementation, the contouring module 103 includes:

In one possible embodiment, the surgical planning module 104 is configured to:

the needle channel deleting module is used for deleting the needle channel;

In one possible implementation, the intraoperative monitoring module 105 includes:

In one possible embodiment, the surgical reporting module 106 includes:

In combination with the composite pulsed electric field tumor ablation planning system provided in the above embodiment of the present application, the functions and the use logic of each module in the composite pulsed electric field tumor ablation planning system are further described in detail below.

In a first aspect, case management.

1. One case comprises initially imported patient information, an image sequence and subsequently added data such as registration, contour, puncture path and treatment parameters, and case management is responsible for sorting all case data. The system manages patient information through a database, and data such as image sequences, registration, contours and operation plans are stored in a local disk (file directory classified storage is generally established by patient numbers), and a storage directory is written into a database record of the patient. The case management system can greatly improve the management efficiency of the patient information.

2. Case management software application: wherein, the left side of the interface is a case information interface, and the case information editing interface can be accessed by clicking the 'editing' button below. The middle is a patient list, after TPS software is started, data can be automatically read from a database at the back end and loaded to the patient list, the left button of a mouse is clicked on any field of the patient list at the head of the list to sort the cases in an ascending or descending manner, a next row of buttons are clicked to create, delete or open and backup the cases respectively, one case is selected in the patient list, and a case information interface at the left side of the interface can display detailed information of the selected case. The right side is a case retrieval interface, retrieval results are displayed in a patient list, and the number above the patient list indicates "number of retrieved patients/total number of patients", and the "clear" button below is clicked to clear all retrieval fields.

3. The new cases were created.

Image data of a treatment region of a patient is the basis of treatment planning, and the system can establish a case by reading DICOM-format image sequences of a plurality of modalities (such as CT, MRI and PET) of the patient. Clicking on the "new case" button below the case management interface patient list pops up a "new case" dialog box.

Clicking the "import DICOM format" button or the "import other format" button may import the corresponding format sequence for the patient. The specific operation flow is as follows: clicking the "import DICOM Format" button pops up a folder selection dialog, and after selecting the folder in which the patient sequence is located, the system will automatically read all sequences and list them to the left of the dialog. Selecting an imported sequence on the left can quickly view axial tomograms of the sequence through a sequence view window in the middle of the dialog box, continuing to click an "add" button below the sequence view window to import the sequence into a case to be newly created, listing the added sequence on the right side of the dialog box, eliminating the sequence from the list of imported sequences on the left side of the dialog box, editing information on the newly created case above the dialog box (an unfilled option system automatically fills in patient information in the sequence when adding the sequence), and conversely, selecting an added sequence on the right side of the dialog box and clicking a "delete" button below can return the sequence to the list of imported sequences on the left side of the dialog box. And finally, clicking a 'confirm' button at the lower right of the dialog box, automatically storing the case information and the image data (the selected sequence to be imported) in a local disk by the system at the back end, uploading the case information and the local storage path to a database, inserting a new case into a patient list of a case management interface, and if the dialog box is closed before clicking the 'confirm' button, not generating the new case by the system and canceling all new case operations.

It should be noted that the patient ID number is a unique identification of the case, is not repeatable, and cannot be modified once created, and if the case ID to be created is duplicated with the existing case ID (in fact, the system will automatically extract the patient ID from its DICOM image sequence, and if not, the system will itself assign a nonrepeating ID to the case to be created), the system will eventually verify and prompt to modify the case ID. In addition, a date column of a case information editing column above the dialog box can fill in the creation time of the case, the creation time of the case cannot be modified once the creation time of the case is determined, and if the date column is not filled in, the DICOM image sequence is automatically filled in the scanning time (if the date column is not filled in, the date column is filled in by the system).

4. Case save and read (open). Double-clicking a case in a patient list of a case management interface, the system can automatically read and load locally stored case data and automatically jump to a preoperative planning option card, and the reading of the case can read not only image data of the case, but also operation planning data stored by a user, such as registration, contour, puncture path and the like. Likewise, saving a case will also save all the data for the case, where the case information and the local storage path will be uploaded to the database. The currently opened case can be saved by clicking a 'save' button on the upper right of the TPS software.

5. The case is edited. In a case information interface on the left side of a case management interface, a 'edit information' button on the lower side is clicked to enter the case information editing interface, wherein a patient ID cannot be modified, the case creation time cannot be modified, the editing time can only be automatically modified by a system, the sequence number is automatically counted and displayed by the system, other information can be freely edited by a user (the system with a 'x' number is a necessary item, wherein the name, the sex and the birthday of a patient can be automatically extracted from an image sequence in a DICOM format), after the 'confirm' button is clicked, the system stores the modified case information locally and updates the case information in a database at the back end, the related information can be updated in a patient list of the case management interface, and the editing is abandoned after the 'cancel' button is clicked.

6. The case was deleted. Selecting a case in the patient list in the middle of the case management interface, clicking the "delete" button below can delete the case, the system will remove the case from the patient list, delete the locally stored data of the case at the back end and delete the case record from the database.

7. The case is retrieved. The case retrieval of the system can retrieve cases according to conditions and time. The retrieval fields are sequentially input in the 'search by condition' part on the right side of the case management interface, the system retrieves cases meeting all the fields, a patient list in the middle of the case management interface is displayed, and a field of 'the number of retrieved patients/the total number of patients' in brackets is updated above the patient list; also selecting a time period in the "filter by time" section, the system will retrieve the case for the case edit time in that time period, and in particular, if the "other" option is selected in that section, the start and end time options pop up below, with the start and end times being customized by the user. Clicking the "clear" button below the case search clears all search fields and options (including the conditional search field and the time filtering option).

8. And (5) managing the sequence.

The image sequence can be imported or deleted; the sequence management section allows a user to add or delete a sequence. Opening a case in the patient list, clicking the "sequence management" button, clicking the "add" button on the upper right side of the tab pops up a "sequence management" dialog box in which the sequence of the current case can be managed (added/deleted). Clicking the 'sequence information' button can modify the mode and period of the image sequence, or remark the sequence, and can delete and turn over the image slices.

In the sequence management dialog, the image sequence of the patient can be added, and the sequence of the current case can be deleted. The addition is the addition of a new image data, and the deletion of the sequence not only deletes the sequence image data, but also deletes all the registration pairs and contour lines associated with the sequence, both of which can be performed simultaneously in the sequence management dialog.

The specific operation flow of the additional sequence is as follows: clicking the "import" button in the upper left corner of the dialog pops up a folder selection dialog, and after selecting the folder in which the patient sequence is located, the system will automatically read all sequences and list them in the list on the top side of the dialog. After a sequence is selected from the introducible sequence list on the upper side of the dialog box, the axial tomography image of the sequence can be quickly browsed in the sequence browsing window in the middle of the dialog box, the sequence can be introduced into the current case by continuously clicking the ' > > ' button on the right side of the sequence browsing window, the sequence is added into the sequence list of the current case on the right side of the ' > > > button, and the introducible sequence list on the upper side of the dialog box can remove the sequence.

An important function of the additional sequence is to add an image sequence in the operation, monitor the needle insertion puncture effect and the operation ablation effect, so as to further adjust and optimize the operation plan in the operation until the requirements are met.

The specific operation flow of the deletion sequence is as follows: the bottom right side of the dialog will list all the sequences of the current case, and selecting one and clicking on the "<" button on its left side can move the sequence to the list of importable sequences on the top side of the dialog.

And finally clicking a 'confirm' button at the lower right of the dialog box, automatically storing the rearranged case information, image data and operation plan data in a local disk by the system at the back end, updating the case information in a database, and if the dialog box is closed before the 'confirm' button is clicked (or clicking a 'cancel' button at the lower right of the dialog box), not performing any operation by the system.

In a second aspect, registration fusion.

1. And (6) registering. When the system imports an image sequence, the DICOM file embedded coordinate information is used as default coordinate information. When sequences scanned at different times or different body positions are introduced into the system in sequence, the actual spatial positions of the sequences may deviate; disturbances such as respiratory motion of the patient may also cause sequence position deviations. If the organ, target area, and surgical plan to be drawn on a sequence are to be applied to other image sequences, the sequences need to be aligned in spatial position.

When a currently open case contains two or more image sequences, the registration function may help the operator align the image sequences spatially. A pair of sequences for alignment is called a "registration pair", wherein a sequence serving as a reference is called a "reference sequence", and the spatial position of the sequence is kept unchanged; the sequence of spatial position changes is called "sequence to be registered". The registration process is to spatially transform the sequence to be registered to the corresponding position of the reference sequence.

2. And registering the fusion interface introduction.

And clicking a registration fusion tab under the preoperative planning tab, and displaying a control panel to adjust a sequence display mode. The "display image" and "fusion image" dropdown frames list all the sequences of the current case; the fusion mode is used for setting the display mode of the display image and the fusion image on the interface; the transverse sliding bar under the 'fusion mode' is used for controlling the mixing proportion of the image.

The registration pair display panel is used to display all currently added registration pairs. The registration pair can be selected, checked and unchecked on the panel. The operation panel is used for completing the registration related function.

3. And (6) carrying out registration.

(1) A registration pair is added.

It is first confirmed that the current case contains two or more image sequences, otherwise the registration function is not available. Clicking the "add registration pair" button in the "action panel" will pop up a "sequence view" dialog box. The sequence display panel lists all image sequences contained in the current case, and the user can quickly browse in the sequence viewing panel by clicking any one of the image sequences. The registration sequence selection panel is used for selecting a reference sequence and a to-be-registered sequence of the registration pair.

And respectively clicking two drop-down boxes, selecting a required sequence, and then clicking an adding button on the right side to establish a registration pair. The newly created registration pair will be displayed in the "registration pair display panel".

(2) And (5) adjusting the visual effect.

After the registration pair is added, the two sequences for registration are displayed superimposed in the image viewing window.

In the registration process, in order to conveniently observe the relative position relationship between the two sequences, an operator can adjust the fusion display effect to make the contrast between the sequences clear.

The "display image" and "fusion image" drop-down boxes in the "display control panel" specify the two sequences that are currently displayed in the window. And dragging the transverse sliding bar below the horizontal sliding bar left and right to adjust the fusion ratio between the sequences.

The window width and level of the image can also be adjusted. Firstly, selecting a sequence needing to be adjusted in a 'display image' drop-down frame, and then clicking a window width and window position adjusting button at the upper right corner of a display window to enter an adjusting mode. After the button is pressed, the left mouse button can be pressed and the mouse can be slid to adjust the window width and the window position of the displayed image. And after the adjustment is finished, clicking a right mouse button to return to a general mode.

(3) And (4) manually registering.

Although the present system provides an automatic registration function, in order to increase the registration speed and improve the registration accuracy, a prior manual registration is necessary before the automatic registration.

The manual registration means that an operator roughly aligns the spatial positions of the two sequences through dragging and rotating operations on a software interface.

When the two sequences have overlarge spatial position difference, the two sequences may not be displayed simultaneously on the display interface, and then the 'center alignment' button can be clicked to adjust the image centers of the sequences to the same position. Then click the "manual registration" button to enter manual registration mode.

After entering the manual registration mode, the left mouse button is pressed and slid on the image interface to translate or rotate the image.

When the position of the mouse is close to the center of the image, the image to be registered can be translated by dragging the mouse; when the position of the mouse is close to the edge of the image, the image to be registered can be rotated by dragging the mouse.

The operator can determine whether the manual registration has reached the requirement by observing the positions of the bones and the typical organs. The method may need to be adjusted at any time in conjunction with the visual effects to assist in the manual registration process.

(4) Automatic rigid body registration.

Rigid body registration refers to applying rotation and translation operations to an image to align the image to be registered with a reference image at a spatial position.

First, manual registration is performed to approximately align the two sequences in spatial position.

In manual registration mode, the yellow dotted line around the window is dragged to set the region of interest (ROI).

The purpose of setting ROI is to reduce the calculation range of registration and accelerate the registration speed. And if no yellow dotted line appears around the window, clicking the region of interest button to call out.

The yellow dashed frame should frame at least important organs, such as liver, lung, etc., and exclude other objects in the image (e.g., CT gantry). If the ROI area is too large, the system pops up a prompt, and the ROI area needs to be modified and retried. Then click the "automatic rigid registration" button to start automatic registration. A progress bar on the interface indicates the current completion progress, and the image to be registered can be observed to gradually move to the position of the reference image in the registration process. Depending on the computer environment and image size, the registration process may take 1-2 minutes. After the registration is finished, the progress bar automatically disappears, and the representation can be used for the next operation.

(5) And (6) automatic deformation registration.

The deformation registration is generally performed on the basis of rigid body registration, and the image is deformed besides translation and rotation, so that the registration accuracy is higher. Deformable registration is generally applied in situations where respiratory motion of the patient causes a large effect or where the patient's position changes.

After the rigid body registration of the previous step is finished, the registration can be finished only by clicking the automatic deformation registration again. Due to the increased amount of computation, the speed of deformation registration is relatively slower than rigid body registration, and the registration process may take 2-3 minutes depending on the computer environment and the size of the image.

(6) And checking the registration effect.

The following several ways can be used to check whether the registration has been satisfactory.

By using the display effect adjusting method, the display effect can be adjusted to the most comfortable state by adjusting the fusion proportion and the window width and window level all the time. In order to check whether the registration is up to the requirement, it is proposed to increase the contrast between the two sequences, and repeatedly adjust the fusion ratio to observe the positions of the important organs and bones.

And adjusting the image fusion mode. The 'fusion mode' drop-down box in the 'display control panel' provides several fusion display modes of Overlay (Overlay), checkerboard (Chessboard), Horizontal Line (Horizontal Line) and Vertical Line (Vertical Line). The default mode is Overlay. If the display mode is switched to another display mode, the corresponding mode is clicked in the pull-down frame.

Wherein the overlay display is a default fusion mode that mixes the two sequences by a certain ratio and displays them on the interface. The user can change the mixing ratio by adjusting a slider bar in the display control panel. The checkerboard display mode divides the display interface into a plurality of squares, and two sequences for fusion are displayed in the squares in a staggered mode. The left mouse button can be pressed and slid on the display interface to adjust the position of the checkerboard, and the corresponding conditions of the two sequences at the boundary of the square blocks can be checked. The horizontal line display mode divides the view into several horizontal regions and staggers the two sequences for fusion in each region. The user may drag the view using a mouse to adjust the position of the horizontal region. The vertical line display mode is similar to the horizontal line display mode.

4. The registration pair is reset.

Click the "reset" button in the "operator panel" to reset the registration pair.

Resetting the registration pair deletes the existing spatial positional relationship and restores the two sequences to the original positions, so this item can be used when mishandled or when it is necessary to start with a new one. Note that this operation causes the target region, organ, and needle track positional relationship to be changed.

5. The registration pair is deleted.

First double-click the intended deleted registration pair in the registration pair display panel, at which point the registration pair appears blue arrow to the left, and then click the "delete registration pair" button.

The deletion of the registration pair simultaneously deletes the spatial correspondence between the two sequences, and simultaneously affects the target region, organ, and needle track with established positional relationship, and before deletion, please determine that deletion is actually needed.

6. Supplementary explanation.

Registration is the basic step in performing multi-sequence planning, suggesting that a constant reference sequence be selected prior to surgical planning, and that the remaining and subsequent image sequences be registered to that sequence.

When the sequence is imported into the system, the system automatically selects a sequence as a reference and uses the sequence as a recommended value. The recommended reference sequence is shown in the reference sequence display box of the display control panel.

Note that the planned needle track position cannot be transferred to a new image sequence before the registration operation is performed. If planning is done before registration, the needle track position cannot be transferred to other image sequences even if registration pairs are subsequently added. Therefore, if there is a need to arrange needle tracks in multiple sequences, it is necessary to ensure that the registration operation is performed first.

In a third aspect, contouring is provided.

1. Outline concept description. Important visceral organs, focus target areas and evasion organs of a patient are sketched out on an image sequence of the patient, three-dimensional reconstruction is carried out, a doctor can be helped to intuitively distinguish the target areas, interested tissues, three-dimensional structures of puncture paths and ablation ranges and spatial orientation relations among the three-dimensional structures, smooth and safe puncture paths can be planned by the doctor, and efficient and accurate ablation treatment parameters can be determined. The system divides the outline into three types of target area, organ and evasion organ, the target area is tumor generally, the organ is skin, liver, lung generally, and the evasion organ includes skeleton, blood vessel. The system provides manual, semi-automatic, and automatic methods to assist in extracting patient contours.

2. And (5) introducing a contour drawing interface. Under the "plan before operation" tab, click the "outline drawing" tab of the left panel, and the outline list is used to display all the outlines currently added. The outline can be selected, selected and deselected on the panel. The selected contour is the current contour and will be highlighted in the contour list. The operation panel is used for completing the related functions of the outline, including the functions of adding, deleting, clearing, sketching, loading and the like of the outline. Note that the function buttons of the contour operation panel can be used after loading a case.

3. The contour is added.

Clicking a ' add contour ' button in an ' operation panel ', popping up a ' add contour ' dialog box, inputting the name of a contour, clicking a color button to select colors, selecting the types of the contour (types of ' tumor ', ' skin ', ' ablation zone ', and the like), selecting a two-dimensional display mode of the contour (no filling ', namely colors are not filled in a two-dimensional closed contour line, and filling colors are filled in the contour line, otherwise, ' filling ', namely colors are filled in the contour line) and a three-dimensional display mode (surface ', namely the surface of a three-dimensional reconstruction model is a surface patch, and a grid ', namely the surface of the three-dimensional reconstruction model is a grid), setting a series of rendering parameters of the three-dimensional model (comprising transparency, mirror reflection coefficient, mirror index, diffuse reflection coefficient and ambient light coefficient), then clicking a ' confirm ' button to successfully add an empty contour to the current case, and after the addition is successfully added, the addition item can be seen in a contour list, as shown in the following figures; conversely, clicking the "cancel" button abandons the addition. And carrying out checking and canceling operations on the outline items in the outline list to control the visible and hidden states of the outline under the two-dimensional and three-dimensional windows.

In particular, in the automatic contour extraction method (such as skin, liver and blood vessel), rendering parameters (such as transparency 0 degree and the like) of the three-dimensional models are set by system recommendation. In addition, double-clicking on a silhouette item in the list of silhouettes also pops up a "silhouette" dialog box, where the attributes of the silhouettes may be modified.

4. Manually sketching the contour. The manual outline sketching function (including a paintbrush and an intelligent paintbrush) and the operation flow are introduced. The manual outline drawing is mainly used for the subsequent repair of the outline and the drawing of the focus target area.

(1) And (5) painting with a brush.

First, an outline is selected in the outline list (no outline is added according to the operation flow described above), a 'brush' button of the operation panel is clicked, and then the operation panel can be sketched on a cross-sectional image in any two-dimensional window under the 'operation planning' tab. When the mouse moves to a certain two-dimensional window, a circle (the center of the circle is a plus sign) with the mouse as the center is displayed, the radius of the circle can be changed by pressing a CTRL key on a keyboard and rolling a mouse wheel, then the outline drawing can be carried out by pressing a left mouse button and moving the mouse, and the left mouse button is released to finish the drawing. And after the sketching is finished, refreshing a three-dimensional model for displaying a sketching result in the three-dimensional window, wherein the position of the three-dimensional model corresponds to the position sketched on the tomogram.

Particularly, if the center of the initial circle drawn next time is in the existing contour, the center of the circle can display a plus sign, and the drawn contour can be merged with the existing contour; otherwise, the center of the initial circle is not in the existing contour, the plus sign at the center of the circle is changed to a minus sign at the moment, which means that the contour after being drawn is cancelled out with the existing contour (namely the crossed part of the existing contour and the newly drawn contour is eliminated), but if the ALT key on the keyboard is pressed and the mouse is moved down, the minus sign at the center of the circle is forced to be changed to the plus sign, and the contour after being drawn is combined with the existing contour at the moment.

(2) Intelligent brush.

The intelligent paintbrush and the paintbrush operate the same, but the finally drawn outline is different, because the intelligent paintbrush can automatically identify the edge of the image in the circle, and extract the part similar to the pixel value of the center of the circle in the circle as the final outline.

5. Semi-automatic contouring. The following describes the semi-automatic contouring function (including thresholding and region growing) and the operational flow. The semi-automatic outline drawing can achieve the purpose of extracting the outline of the interested tissue only by a small amount of user operation.

(1) And (5) carrying out threshold segmentation.

First selecting an outline in the outline list (without adding an outline according to the operation flow), and then clicking the 'threshold segmentation' button of the operation panel pops up a 'threshold segmentation' dialog box.

First, a yellow dotted line around the window is dragged to set a region of interest (ROI). The purpose of setting the ROI is to narrow the calculation range of registration and accelerate the segmentation speed. And if no yellow dotted line appears around the window, clicking the region of interest button to call out. The yellow dashed box should frame at least the tissue that is desired to be segmented, e.g. liver, lung, etc., and exclude other objects in the image, e.g. the CT gantry. In addition, the shape of the region of interest can be selected in the lower right corner of the dialog box (there are two options, cube and ellipsoid, the system defaults to cube).

Then, the window width (blue line) or window level (red line) is dragged on the "gray histogram" of the current sequence to adjust the threshold range of the threshold segmentation, but it is of course also possible to adjust the "low threshold" and "high threshold" options below the "gray histogram of the sequence" to precisely determine the threshold range of the threshold segmentation. In the process of adjusting the threshold range of the threshold segmentation, the two-dimensional sequence browsing window updates the segmentation result (i.e. the range covered by the semi-transparent red mask) in real time. The lowest right corner of the dialog box can also be selected to reserve the largest number of regions (5 options of 'all', '1', '2', '3' and '4'), namely the connected regions with the largest volume in the result of the final threshold segmentation, and other connected regions are discarded. Finally, clicking a 'confirm' button to carry out threshold segmentation, wherein waiting for a period of time is needed, and the segmented outline can cover the outline data of the current outline; and clicking a cancel button to abandon the threshold segmentation operation.

(2) And (5) growing the region.

First, an outline is selected in the outline list (no outline is added according to the operation flow), and then, a 'region growing' dialog box pops up by clicking a 'region growing' button of the operation panel.

First, click the "region of interest" button, drag the yellow dotted line around the window to set the region of interest (ROI). The purpose of setting the ROI is to narrow the calculation range of registration and accelerate the segmentation speed. The yellow dashed box should frame at least the tissue that is desired to be segmented, e.g. liver, lung, etc., and exclude other objects in the image, e.g. the CT gantry. In addition, the shape of the region of interest can be selected in the lower right corner of the dialog box (there are two options of Cube and Ellipsoid, the system defaults to Cube). Then clicking a 'target area delineating' button at the lower right corner of the dialog box, delineating the target area in a two-dimensional sequence browsing window, displaying the target area in the two-dimensional sequence browsing window by using a red opaque mask, then clicking a 'background area delineating' button at the lower right corner of the dialog box to delineate a background area, displaying the background area by using a green opaque mask, and finally clicking a 'segmentation' button at the lower right corner of the dialog box to perform region growing segmentation, wherein a period of time is required to wait, and the segmentation result is displayed by using the red opaque mask. If the result is not satisfied, the relevant button can be continuously clicked to add more targets and background areas for segmentation, and of course, the 'clear seed area' button can be clicked to clear all the targets and background areas. Finally, clicking a 'confirm' button, wherein the segmented outline covers the outline data of the current outline; and clicking a cancel button to abandon the threshold segmentation operation.

6. And automatically drawing the outline.

The automatic outline delineation function (including automatic segmentation of skin, liver and blood vessels) and the operation flow are introduced. The automatic outline drawing is completely automatically performed by the system for adding, matching and extracting the outline without the participation of a user.

(1) The skin is automatically segmented.

Clicking a 'skin' button of the automatic segmentation functional area, waiting for a moment, then segmenting the skin of the current sequence, and automatically matching colors for the skin outline by the system. However, it should be noted that if the skin contour data exists in the current sequence, the system will not extract the skin again, and if the skin is to be extracted again, the "clear all" button of the operation panel is clicked to clear the skin contour data of the current sequence. Extracting the skin contour may help automatically pick up the punctured needle insertion point to the skin surface. When the mouse is moved to the contour line of the skin, the characters of the skin are displayed.

(2) The bone is automatically segmented.

Clicking a 'skeleton' button of the automatic segmentation functional area, waiting for a moment, then segmenting the skin of the current sequence, and automatically matching colors for the skin outline by the system. However, it should be noted that if the bone contour data of the current sequence already exists, the system will not extract the bone, and if the bone is to be extracted again, the "clear all" button of the operation panel is clicked to clear the bone contour data of the current sequence.

(3) The liver is automatically segmented.

Clicking a 'liver' button of the automatic segmentation functional area, after waiting for a moment, segmenting the liver of the current sequence, and automatically matching colors for the liver outline by the system. However, it should be noted that if the liver contour data exists in the current sequence, the system will not extract the liver again, and if the liver is to be extracted again, the "clear all" button of the operation panel is clicked to clear the liver contour data of the current sequence. Due to the long waiting time, the system additionally starts a thread to segment the liver, so that the following operation can be continued without waiting for the liver segmentation result.

(4) And (4) automatically segmenting the blood vessel.

Clicking a 'CTA blood vessel' button of the automatic segmentation functional area, waiting for a moment, segmenting the blood vessel of the current sequence, and automatically matching colors for the blood vessel outline by the system. However, it should be noted that if the current sequence has blood vessel contour data, the system will not extract the blood vessel any more, and if the blood vessel is to be extracted again, the "clear all" button of the operation panel is clicked to clear the blood vessel contour data of the current sequence. Due to the long waiting time, the system additionally starts a thread to segment the blood vessel, so that the following operation can be continued without waiting for the result of the blood vessel segmentation. The blood vessel is an important evasion organ, the puncture path of the ablation needle should avoid a large blood vessel, and the existence of the blood vessel can influence the ablation range, so that the blood vessel segmentation has great significance for subsequent operation planning. It should be noted that vessel segmentation requires segmentation on an angiographic image sequence (e.g., CTA), otherwise vessels, especially veins, cannot be identified.

7. And (5) scaling the contour.

Selecting a outlined outline in the outline list, and clicking an outline zooming button of the operation panel to pop up an outline zooming dialog box. The outline zoom size (zoom in when the number is positive and zoom out when the number is negative) may be selected in the "outline zoom" dialog box, and finally the "ok" button is clicked to zoom in. Since the doctor recommends that the ablation range will be expanded a little bit during the operation in order to ensure the tumor tissue to be completely ablated, we can expand the target area by several millimeters through the function.

8. And (5) profile interpolation.

In order to facilitate a user to quickly and manually draw the contour, the system needs to provide a contour line automatic interpolation function, so that the user does not need to draw contour lines on each layer, and the contour lines in the middle layer can be automatically inserted. The specific operation flow is as follows: a user adds a contour, then manually draws (brushes or intelligent brushes) several layers of contour lines, clicks a contour interpolation button on an operation panel, and linearly inserts the contour line of the middle layer by slightly carving the contour line by a system. Of course, if a certain contour is missed by one or two layers and not drawn, the contour can be completed by one key through the function.

9. And (6) mapping the contour.

Contour mapping refers to converting a target region or an organ delineated on a certain sequence into another sequence through a registration relation so as to view or perform surgical planning on the other sequence. To use this function, the target area or organ (contour) needs to be first delineated on the sequence and then the contour that needs to be mapped is selected. And determining that the sequence registration process is finished and the registration result meets the requirement, clicking a contour mapping button in an operation panel, popping up a contour mapping dialog box, selecting the contour to be mapped, and clicking confirmation to finish the operation.

10. Clearing the contour lines and deleting the contour lines.

Contour deletion operation: selecting a contour in the contour list, and then clicking the "delete contour" button of the operation panel, the contour is deleted in the current case, and the contour item is also removed in the contour list, it should be noted that if there are multiple sequences in the case, the contour data of all the sequences will be cleared, and the current case has no contour.

Contour clearing operation: the contour data of the current image is cleared by selecting one contour in the contour list and clicking the "clear current" button of the operation panel. Clicking the "clear all" button clears the contour data of the current sequence of the current case, but unlike the contour deletion operation, the contour data of the other sequences are not affected and the contour item is not removed from the contour list, i.e., the current case does not remove the contour, but the contour data of the current sequence of the current case is cleared.

11. Supplementary explanation.

And the operation panel is also provided with a 'profile loading' button, and after the button is clicked and a folder is selected in the folder selection dialog box, the system can automatically read the three-dimensional model data in the folder according to the file name and the file type and convert the three-dimensional model data into a corresponding profile. Finally, the system will list the generated outlines one by one in the outline list and automatically match the colors. Clicking "save" can save the currently selected profile to the local hard disk.

Finally, the user is advised to directly and automatically extract the contour by one key, and then the contour is manually drawn and perfected on the basis of the automatically extracted contour, and if the contour is the target area, the user is advised to directly and manually draw; semi-automatic segmentation is also a good interesting tissue extraction aid in some cases, reducing the amount of manual delineation by the user.

In a fourth aspect, a surgical plan.

1. The surgical Plan (Plan) is a needle track (Trajectory) arrangement; adjusting and managing needle paths; simulating an action field and an ablation process; the process of determining the treatment parameters. In the system, a plurality of operation plans can be established under a certain case name, and the system is suitable for the requirements of a plurality of treatments. Each surgical plan may include several needle tracks, i.e., the needle tracks actually punctured during a single surgical procedure. Through the operation plan, the treatment parameters meeting the treatment requirements are finally obtained. The parameters include needle track type, spatial position and orientation, effect of action field, duration of treatment, etc.

A prerequisite for surgical planning is that the lesion (target volume) has been delineated for the case. In some cases, it may be necessary to delineate other important organs (e.g. liver, blood vessels) for the case. In addition, if surgical planning is required over multiple sequences, please ensure that the necessary sequence registration work has been completed.

2. A surgical planning interface.

This section introduces the "surgical planning" panel. Under the "surgical planning" tab, click on the surgical planning tab of the left panel.

The import panel is used for importing the planned plan. The management panel is used for managing all plans under the current case name, including a new plan and a deletion plan. The selected plan among the "selection plans" is referred to as a "current plan". The needle track list is used for listing all needle tracks under the current plan. The needle distribution function panel is a main function area of an operation plan, and provides functions of needle channel addition, deletion, modification, action field and ablation process simulation and needle channel safety detection. Some of which are not only available under certain conditions. If the button is gray, it indicates that the condition for using the function is not currently met. The "switch view" button may be used when quickly switching display layouts.

3. And managing the operation plan.

Before the operation, a surgical plan is first established for the case. Clicking the plan "manage" button brings up a "manage preoperative plan" dialog box. Clicking the dialog "add" button creates a new plan.

When a case has a surgical plan, the corresponding plan can be clicked and then the "delete" button can be clicked to delete the plan. Note that deleting the plan would delete the needle track under the plan at the same time, please decide with caution. Selecting a plan, clicking the "export" button, can export the plan to the local hard disk. And then click the close button in the upper right corner of the dialog box to close the dialog box. Selecting the plan drop-down box displays the current plan.

4. And arranging needle paths. Note that before the needle is deployed, please complete the necessary registration steps and add at least one plan.

(1) Needle tracks are added.

To add a needle duct, a needle duct adding button of the operation panel is clicked to call out a needle duct adding dialog box. The needle track name and the needle track color are automatically generated in the dialog box and can be modified as required. The diameter and length of the needle channel are fixed. After the completion, clicking the 'confirm' button of the dialog box, the newly added needle track will be displayed in the needle track list.

(2) And (5) automatically arranging needles.

The automatic needle distribution means that the needle distribution is automatically carried out according to the position, the shape and the size of a target area (tumor). The main needle and the auxiliary needles are used in a matching way, and the number of the auxiliary needles can be set according to the shape and the size of an ablation target area (tumor).

The main needle is automatically distributed.

In the needle arrangement functional area, a 'main needle automatic needle arrangement' button is clicked to pop up a needle arrangement dialog box, and the name and the color of a needle path can be modified as required. After clicking the "ok" button, the master pointer will be displayed in the image profile area. And the left mouse button can be continuously clicked to drag the two ends of the main needle for fine adjustment until the user is satisfied.

When the needle channel is completely positioned on the plane displayed by the current view, the needle body is displayed as a solid line with a corresponding color; when the needle path intersects with the current view plane, the needle body at the intersection is displayed as a section of solid line, and the rest part is displayed as a broken line; when the needle path does not intersect the display plane, the needle body is shown as a dotted line. It should be noted that before the automatic needle placement of the main needle, which will keep the point of entry on the skin surface and insert it into the appropriate location of the tumor, the displayed sequence must be subject to skin segmentation and the target area (tumor) contour added.

② the secondary needle is automatically distributed.

After the main needle is added, the 'auxiliary needle automatic needle arrangement' button is clicked, and an auxiliary needle automatic needle arrangement dialog box appears. The needle track name, color, number, and distance of the sub needle from the main needle may be modified as desired. After clicking the "ok" button, the secondary needles will be displayed in the image contour area and all secondary needles will remain parallel to the primary needle. After the needles are distributed, the needle track information and the views are displayed in the needle track list and the views at different angles.

5. The needle track is deleted.

Firstly, the needle way to be deleted is clicked in the needle way list, and after the appearance of the needle way appears "→", then a button of the operation panel for deleting the needle way is clicked. Note that the needle track needs to be deleted and then added again, please take care.

6. And (6) safety inspection.

The needle path safety detection function can assist in judging whether the puncture path touches organs and tissues such as bones and blood vessels which are to be avoided. After the needle track is arranged, if the needle track does not avoid organs such as blood vessels, bones and the like, in a safety inspection area, an' unsafe needle track! Click to view details "; if avoided, it shows "no unsafe factor found".

Note that: before the function is used, the segmentation of bones, blood vessels and other organs needs to be completed, and areas needing to be avoided are drawn according to needs, please refer to corresponding parts of the document.

7. And (5) simulating an action field.

After the needle channel arrangement is completed, the action field simulation can be carried out. The action field simulation refers to that before treatment, the system is utilized to check the simulation results of the distribution of the action fields near different needle channels in the treatment process so as to assist in formulating reasonable treatment parameters.

After arranging the needle tracks, clicking a button for drawing an action field, popping up a dialog box for drawing an option for drawing an ablation field, pointing the needle tracks, modifying the ablation height as required, and clicking a button for confirmation, thereby generating the action field in a simulated manner among the corresponding needle tracks. Note that the probe of the system is composed of a main needle and secondary needles, the main needle is a positive pole, all the secondary needles are negative poles, and when an action field is drawn, after the main needle is selected, single negative poles are respectively selected to draw the action field in sequence. After the action field is generated, the situation of the simulated action field can be observed in different views. And if the action field can not completely wrap the tumor, clicking a needle withdrawing button, popping up a needle withdrawing dialog box, setting a needle withdrawing distance, and clicking confirmation to complete needle withdrawing. After needle withdrawal is completed, an action field is drawn between the main needle and each auxiliary needle again until the action field completely wraps the tumor. After the action field simulation is completed, a button for clearing the current action field can be clicked according to the requirement, and the drawn action field can be cleared.

In a fifth aspect, intraoperative monitoring.

After the operation plan is formulated, the image sequence in the operation is imported, the plan can be optimized and adjusted, the initial resistance value of the tumor and the final resistance value after ablation are obtained according to the probe, and the operation effect is observed.

1. And (4) planning optimization.

Before plan optimization, the planned surgical plan is imported. It should be particularly noted that prior to importing the surgical plan, the intraoperative image sequence should be registered with the preoperative sequence and the contours delineated in the preoperative sequence mapped into the intraoperative sequence, and in the surgical plan area of the plan optimization page, all functions of the surgical plan panel in the preoperative plan can be followed.

In operation, after inserting needle according to operation plan, it is difficult to completely coincide the actual needle path with the planned needle path in general. At this time, the planned needle path can be adjusted and optimized according to the actual needle path. And drawing an action field after adjustment, and if the action field can still wrap the tumor, performing an operation according to the actual needle path to achieve an ablation effect. If the applied field does not cover the tumor, a re-insertion of the needle is required.

2. Dynamic ablation.

Note that: this functionality requires the incorporation of ablation instrument hardware. After the ablation instrument is correctly connected with the system, the ablation process can be displayed in real time. The monitoring page clicks "dynamic ablation" into the ablation control page during surgery. Comprises a needle track list, a dynamic ablation functional area and an ablation field completion state display area.

In the dynamic ablation function area, the connection state of the software and the ablation instrument can be displayed by clicking an ablation instrument state button; clicking an initial resistance button to display the current needle track information; after the test resistor is operated on the ablation instrument, the initial resistance value between the selected needle channels is displayed in the 'ablation field completion state' area, and the termination resistance value is displayed after the discharge ablation; after clicking the next needle channel button, the operations of discharging, displaying the initial resistance value and terminating the resistance value before repeating between the next two needle channels can be continued.

By reducing the resistance value, the ablation effect between needle tracks can be judged. After the ablation operation is completed at one depth, the needle can be withdrawn and the above operations can be repeated until the purpose of ablating the whole tumor is achieved.

In a sixth aspect, a surgical report.

1. Surgical report concept description. The surgical report is divided into a preoperative planning scheme and a treatment report. The preoperative planning scheme is the last ring of preoperative planning, converts the formulated operation plan content and treatment process into an intuitive report form, thus facilitating the clinical communication of doctors, assisting the doctors in operation, and simultaneously archiving the operation process record of patients. After the user completes the surgical planning and treatment, the system automatically generates a planning plan and a treatment report. The user can also customize the operation report needed by the user, such as selecting a needed report module and cutting a needed operation plan picture into the report.

2. A surgical reporting interface. Turning to a preoperative planning scheme interface visible in an operation report from a preoperative planning page in TPS software; the treatment report interface is visible from the "intraoperative monitoring" page to the "surgical report" page.

The left side of the report screenshot management module is a report content browsing window, the middle of the report screenshot management module occupies a large area, and buttons on the lower side of the report screenshot management module can operate a report page. It should be noted that if the user does not add any operation plan to the current case, the system will not generate an operation report, and after adding any operation plan, the system will generate an operation report of the current case (i.e. the operation reports corresponding to different plans are different), and specifically, the system will automatically add case information (basic information of the patient and the size and position of the lesion), needle track information (the number of needles, the needle track position and ablation parameters) to the report content.

3. And (5) screenshot management.

The "screenshot management" section is located to the left of the "surgical report" interface. The user adds the screenshot to the operation report, and firstly, the screenshot operation is carried out, and the screenshot operation can be selected by clicking a right mouse button in the preoperative planning and intraoperative monitoring pages. After the operation is completed, the captured image will be displayed in the operation report immediately.

4. Browsing and printing.

The report can be conveniently browsed in an operation report browsing window of an operation report interface, and the operation report in a PDF format can be exported and stored in a local hard disk by clicking a PDF exporting button on the lower left, so that the operation report can be conveniently browsed and printed.

Based on the same technical concept, an embodiment of the present application further provides an apparatus, including: the device comprises a data acquisition device, a processor and a memory; the data acquisition device is used for acquiring data; the memory is to store one or more program instructions; the processor is configured to execute one or more program instructions to perform the method.

Based on the same technical concept, the embodiment of the present application also provides a computer-readable storage medium, wherein the computer-readable storage medium contains one or more program instructions, and the one or more program instructions are used for executing the method.

In the present specification, each embodiment of the method is described in a progressive manner, and the same and similar parts among the embodiments are referred to each other, and each embodiment focuses on the differences from the other embodiments. Reference is made to the description of the method embodiments.

It is noted that while the operations of the methods of the present invention are depicted in the drawings in a particular order, this is not a requirement or suggestion that the operations must be performed in this particular order or that all of the illustrated operations must be performed to achieve desirable results. Additionally or alternatively, certain steps may be omitted, multiple steps combined into one step execution, and/or one step broken down into multiple step executions.

Although the present application provides method steps as in embodiments or flowcharts, additional or fewer steps may be included based on conventional or non-inventive approaches. The order of steps recited in the embodiments is merely one manner of performing the steps in a multitude of orders and does not represent the only order of execution. When an apparatus or client product in practice executes, it may execute sequentially or in parallel (e.g., in a parallel processor or multithreaded processing environment, or even in a distributed data processing environment) according to the embodiments or methods shown in the figures. The terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, the presence of additional identical or equivalent elements in a process, method, article, or apparatus that comprises the recited elements is not excluded.

The units, devices, modules, etc. set forth in the above embodiments may be implemented by a computer chip or an entity, or by a product with certain functions. For convenience of description, the above devices are described as being divided into various modules by functions, and are described separately. Of course, in implementing the present application, the functions of each module may be implemented in one or more software and/or hardware, or a module implementing the same function may be implemented by a combination of a plurality of sub-modules or sub-units, and the like. The above-described embodiments of the apparatus are merely illustrative, and for example, the division of the units is only one logical division, and other divisions may be realized in practice, for example, a plurality of units or components may be combined or integrated into another system, or some features may be omitted, or not executed. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection through some interfaces, devices or units, and may be in an electrical, mechanical or other form.

Those skilled in the art will also appreciate that, in addition to implementing the controller as pure computer readable program code, the same functionality can be implemented by logically programming method steps such that the controller is in the form of logic gates, switches, application specific integrated circuits, programmable logic controllers, embedded microcontrollers and the like. Such a controller may therefore be considered as a hardware component, and the means included therein for performing the various functions may also be considered as a structure within the hardware component. Or even means for performing the functions may be regarded as being both a software module for performing the method and a structure within a hardware component.

The application may be described in the general context of computer-executable instructions, such as program modules, being executed by a computer. Generally, program modules include routines, programs, objects, components, data structures, classes, etc. that perform particular tasks or implement particular abstract data types. The application may also be practiced in distributed computing environments where tasks are performed by remote processing devices that are linked through a communications network. In a distributed computing environment, program modules may be located in both local and remote computer storage media including memory storage devices.

From the above description of the embodiments, it is clear to those skilled in the art that the present application can be implemented by software plus necessary general hardware platform. Based on such understanding, the technical solutions of the present application may be embodied in the form of a software product, which may be stored in a storage medium, such as a ROM/RAM, a magnetic disk, an optical disk, or the like, and includes several instructions for enabling a computer device (which may be a personal computer, a mobile terminal, a server, or a network device) to execute the method according to the embodiments or some parts of the embodiments of the present application.

The embodiments in the present specification are described in a progressive manner, and the same or similar parts among the embodiments are referred to each other, and each embodiment focuses on the differences from the other embodiments. The application is operational with numerous general purpose or special purpose computing system environments or configurations. For example: personal computers, server computers, hand-held or portable devices, tablet-type devices, multiprocessor systems, microprocessor-based systems, set top boxes, programmable electronic devices, network PCs, minicomputers, mainframe computers, distributed computing environments that include any of the above systems or devices, and the like.

The above-mentioned embodiments are further described in detail for the purpose of illustrating the invention, and it should be understood that the above-mentioned embodiments are only illustrative of the present invention and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims

1. A composite pulsed electric field tumor ablation planning system, the system comprising:

2. The system of claim 1, wherein the case management module comprises:

3. The system of claim 1, wherein the registration fusion module comprises:

4. The system of claim 1, wherein the contouring module comprises:

5. The system of claim 1, wherein the surgical planning module is to:

the needle channel deleting module is used for deleting the needle channel;

6. The system of claim 1, wherein the intraoperative monitoring module comprises:

7. The system of claim 1, wherein the surgical reporting module comprises: