CN117563139B - Device and processor for inhibiting tumor proliferation by using electric field - Google Patents
Device and processor for inhibiting tumor proliferation by using electric field Download PDFInfo
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Abstract
The application provides a device and a processor for inhibiting tumor proliferation by utilizing an electric field, comprising: an alternating voltage source, at least one pair of electrodes, a processor, and a controller; the processor is used for obtaining the field intensity of a tumor area in the in-vivo tissue through simulation according to the output voltage of the electrode to the in-vivo tissue, the position information of the electrode and the image data of the in-vivo tissue, and adjusting the set value of the output voltage according to the field intensity; and/or obtaining a predicted temperature through simulation according to the temperature data, the output voltage, the position information of the electrode and the image data of the in-vivo tissue, and adjusting a set value of the output voltage according to the predicted temperature, wherein the temperature data indicates the temperature of the contact area of the electrode and the skin; and the controller is used for controlling the alternating voltage source to output voltage according to the set value. According to the method and the device, the temperature of the electrode plate contacting the surface of the user can be controlled on the premise that the output voltage of the device for inhibiting tumor proliferation by using the electric field is kept, and the shutdown frequency of the device for inhibiting tumor proliferation by using the electric field is reduced.
Description
Technical Field
The application belongs to the field of medical equipment, and in particular relates to equipment and a processor for inhibiting tumor proliferation by using an electric field.
Background
In the field of tumor treatment, the inhibition of tumor cells depends on the strength of the electric field applied to the target location, which is determined by the voltage value output from the AC voltage source to the electrodes. The electric field applied to the patient is typically applied by electrode pads attached to the body surface of the user in a device that inhibits tumor proliferation using the electric field. In view of human safety, it is generally required that the temperature of the skin portion of the human body contacted with the medical device cannot exceed a target temperature value, for example, 41 ℃. Therefore, most devices for inhibiting tumor proliferation by using an electric field stop working after detecting that the measured temperature value of the electrode plate is greater than the target temperature value, and can be restarted after waiting for a period of time, so that the user is prevented from being damaged by high temperature.
However, in the operation of the apparatus for suppressing tumor proliferation using an electric field, if the output voltage value of the apparatus for suppressing tumor proliferation using an electric field is set to be small, the therapeutic effect of the apparatus for suppressing tumor proliferation using an electric field is poor. If the output voltage value of the device for inhibiting tumor proliferation by using the electric field is set to be larger, the temperature of the electrode plate contacting the surface of the user body in the using process may be larger than the target temperature value, so that the device for inhibiting tumor proliferation by using the electric field is frequently stopped, and the using experience of the user is reduced.
Therefore, how to control the temperature of the electrode sheet contacting the surface of the user body while maintaining the output voltage of the apparatus for suppressing tumor proliferation by using the electric field, and to reduce the shutdown frequency of the apparatus for suppressing tumor proliferation by using the electric field is a problem to be solved.
Disclosure of Invention
In order to solve the above-mentioned problems of the prior art, an apparatus and a processor for suppressing tumor proliferation by using an electric field are proposed, and the above-mentioned problems can be solved by using the apparatus.
The present application provides the following solutions.
In a first aspect, the present application provides an apparatus for inhibiting tumor proliferation using an electric field, comprising: an alternating voltage source, at least one pair of electrodes, a processor, and a controller;
the electrode is used for being attached to the body surface of a user, the alternating voltage source is electrically connected with the electrode, and the alternating voltage source is used for applying alternating voltage to internal tissues through the electrode;
the processor is used for obtaining the field intensity of a tumor area in the in-vivo tissue through simulation according to the output voltage of the electrode to the in-vivo tissue, the position information of the electrode and the image data of the in-vivo tissue in the process of outputting the alternating voltage by the alternating voltage source, and adjusting the set value of the output voltage according to the field intensity;
and/or a processor, in the process of outputting alternating voltage by the alternating voltage source, for obtaining a predicted temperature through simulation according to temperature data, output voltage, position information of the electrode and image data of in-vivo tissues, and adjusting a set value of the output voltage according to the predicted temperature, wherein the temperature data indicates the temperature of a contact area of the electrode and skin;
And the controller is used for controlling the alternating voltage source to output voltage to the internal tissues through the electrodes according to the set value.
In some possible embodiments, the processor is specifically configured to obtain, through simulation, a field intensity of a tumor region in the in-vivo tissue according to the output voltage, the position information of the electrode, and the image data of the in-vivo tissue in the process of outputting the alternating voltage by the alternating voltage source;
the controller is used for adjusting the set value of the output voltage when the field intensity is smaller than a preset field intensity threshold value.
In some possible embodiments, the processor is specifically configured to obtain, through simulation, a predicted temperature according to the temperature data, the output voltage, the position information of the electrode, and the image data of the tissue in the body during the process of outputting the alternating voltage by the alternating voltage source;
the controller is used for adjusting the set value of the output voltage when the predicted temperature is smaller than or equal to the preset temperature threshold value, and adjusting the set value of the output voltage when the predicted temperature is larger than the preset temperature threshold value.
In some possible embodiments, the processor is specifically configured to obtain, through simulation, field intensity of a tumor area in the in-vivo tissue according to an output voltage of the electrode to the in-vivo tissue, position information of the electrode, and image data of the in-vivo tissue, and obtain, through simulation, a predicted temperature according to the temperature data, the output voltage, the position information of the electrode, and the image data of the in-vivo tissue, in outputting the alternating voltage by the alternating voltage source;
The controller is used for adjusting the set value of the output voltage when the field intensity of the tumor area is larger than a preset field intensity threshold value and the predicted temperature is smaller than or equal to a preset temperature threshold value.
In some possible embodiments, the image data of the in vivo tissue comprises image data of the in vivo tissue comprising a slice of the target slice image; the processor is used for obtaining the field intensity of a tumor area in the internal tissue through simulation according to a target slice image in the multi-layer slice image, the output voltage of the electrode to the internal tissue and the position information of the electrode in the process of outputting the alternating voltage by the alternating voltage source, and adjusting the set value of the output voltage according to the field intensity; and/or the processor is used for obtaining the predicted temperature through simulation according to the temperature data, the output voltage, the position information of the electrode and the target slice image in the multi-layer slice image in the process of outputting the alternating voltage by the alternating voltage source, and adjusting the set value of the output voltage according to the predicted temperature.
In some possible embodiments, the apparatus further comprises: a temperature collector;
and the temperature collector is used for collecting temperature data of the contact area of the electrode and the skin.
In some possible embodiments, the device comprises a plurality of pairs of electrodes;
And the processor is also used for obtaining electrode temperature distribution information through simulation according to the temperature data, the output voltage, the position information of the electrodes and the image data of the internal tissues of each electrode in the plurality of pairs of electrodes, wherein the electrode temperature distribution information comprises the predicted temperature of each electrode.
In some possible embodiments, the processor is further configured to control an output current of the alternating voltage source through the electrode to the tissue in the body to be less than a current threshold during output of the alternating voltage by the alternating voltage source.
In some possible embodiments, the processor is specifically configured to obtain, through simulation, a field intensity of a tumor region in the in-vivo tissue according to a current output voltage output by the electrode to the in-vivo tissue, position information of the electrode, and image data of the in-vivo tissue, and determine, according to the field intensity, a first voltage value, where the first voltage value is positively correlated with a difference between the field intensity and a preset field intensity threshold;
determining a second voltage value according to the current output by the electrode;
the set point is determined from the greater of the first voltage value and the second voltage value.
In some possible embodiments, the processor is further configured to determine a third voltage value according to a preset current threshold;
Taking the smaller value of the third voltage value and the second voltage value as a first target voltage value;
the set point is determined from the greater of the first target voltage value and the first voltage value.
In some possible embodiments, the processor is further configured to determine a fourth voltage value based on a temperature of the electrode in contact with the skin;
determining a fifth voltage value according to the temperature threshold;
taking the smaller value of the fourth voltage value and the fifth voltage value as a second target voltage value;
taking the larger value of the first target voltage value and the first voltage value as a third target voltage value;
the set value is determined from the smaller of the second target voltage value and the third target voltage value.
In some possible embodiments, the tumor region is a region previously determined in the image data of the in vivo tissue.
In a second aspect, the present application provides a processor for use in an apparatus for inhibiting tumor proliferation using an electric field, the apparatus further comprising: an alternating voltage source, at least one pair of electrodes, and a controller;
the electrode is used for being attached to the body surface of a user, the alternating voltage source is electrically connected with the electrode, and the alternating voltage source is used for applying alternating voltage to internal tissues through the electrode;
the processor is used for obtaining the field intensity of a tumor area in the in-vivo tissue through simulation according to the output voltage of the electrode to the in-vivo tissue, the position information of the electrode and the image data of the in-vivo tissue in the process of outputting the alternating voltage by the alternating voltage source, and adjusting the set value of the output voltage according to the field intensity;
And/or a processor, which is used for obtaining the predicted temperature through simulation according to the temperature data, the output voltage, the position information of the electrode and the image data of the tissue in the body in the process of outputting the alternating voltage by the alternating voltage source, and adjusting the set value of the output voltage according to the predicted temperature, wherein the temperature data indicates the temperature of the contact area of the electrode and the skin;
and the controller is used for controlling the alternating voltage source to output voltage to the internal tissues through the electrodes according to the set value.
In some possible embodiments, the processor is specifically configured to obtain, through simulation, a field intensity of a tumor region in the in-vivo tissue according to the output voltage, the position information of the electrode, and the image data of the in-vivo tissue in the process of outputting the alternating voltage by the alternating voltage source;
the controller is used for adjusting the set value of the output voltage when the field intensity is smaller than a preset field intensity threshold value.
In some possible embodiments, the processor is specifically configured to obtain, through simulation, a predicted temperature according to the temperature data, the output voltage, the position information of the electrode, and the image data of the tissue in the body during the process of outputting the alternating voltage by the alternating voltage source;
the controller is used for adjusting the set value of the output voltage when the predicted temperature is smaller than or equal to the preset temperature threshold value in the process of outputting the alternating voltage by the alternating voltage source, and adjusting the set value of the output voltage when the predicted temperature is larger than the preset temperature threshold value.
In some possible embodiments, the processor is specifically configured to obtain, through simulation, field intensity of a tumor area in the in-vivo tissue according to an output voltage of the electrode to the in-vivo tissue, position information of the electrode, and image data of the in-vivo tissue, and obtain, through simulation, a predicted temperature according to the temperature data, the output voltage, the position information of the electrode, and the image data of the in-vivo tissue, in outputting the alternating voltage by the alternating voltage source;
the controller is used for adjusting the set value of the output voltage when the field intensity of the tumor area is larger than a preset field intensity threshold value and the predicted temperature is smaller than or equal to a preset temperature threshold value.
In some possible embodiments, the image data of the in vivo tissue comprises image data of the in vivo tissue comprising a slice of the target slice image; the processor is used for obtaining the field intensity of a tumor area in the internal tissue through simulation according to a target slice image in the multi-layer slice image, the output voltage of the electrode to the internal tissue and the position information of the electrode in the process of outputting the alternating voltage by the alternating voltage source, and adjusting the set value of the output voltage according to the field intensity; and/or a processor for obtaining a predicted temperature through simulation according to the temperature data, the output voltage, the position information of the electrode and the target slice image in the multi-layer slice image, and adjusting a set value of the output voltage according to the predicted temperature.
In some possible embodiments, the apparatus further comprises: a temperature collector;
and the temperature collector is used for collecting temperature data of the contact area of the electrode and the skin.
In some possible embodiments, the device comprises a plurality of pairs of electrodes;
and the processor is also used for obtaining electrode temperature distribution information through simulation according to the temperature data, the output voltage, the electrode position information and the in-vivo tissue image data of each electrode in the plurality of pairs of electrodes in the process of outputting the alternating voltage by the alternating voltage source, wherein the electrode temperature distribution information comprises the predicted temperature of each electrode.
In some possible embodiments, the processor is specifically configured to obtain, through simulation, a field intensity of a tumor region in the in-vivo tissue according to a current output voltage output by the electrode to the in-vivo tissue, position information of the electrode, and image data of the in-vivo tissue, and determine, according to the field intensity, a first voltage value, where the first voltage value is positively correlated with a difference between the field intensity and a preset field intensity threshold;
determining a second voltage value according to the current output by the electrode;
the set point is determined from the greater of the first voltage value and the second voltage value.
In some possible embodiments, the processor is further configured to determine, during output of the alternating voltage by the alternating voltage source, a third voltage value according to a preset current threshold;
Taking the smaller value of the third voltage value and the second voltage value as a first target voltage value;
the set point is determined from the greater of the first target voltage value and the first voltage value.
In some possible embodiments, the processor is further configured to determine a fourth voltage value based on a temperature of the electrode in contact with the skin during output of the alternating voltage by the alternating voltage source;
determining a fifth voltage value according to the temperature threshold;
taking the smaller value of the fourth voltage value and the fifth voltage value as a second target voltage value;
taking the larger value of the first target voltage value and the first voltage value as a third target voltage value;
and determining the set value according to the smaller value of the second target voltage value and the third target voltage value.
According to the device for inhibiting tumor proliferation by using the electric field, provided by the embodiment of the application, the field intensity or the predicted temperature of a tumor area in the internal tissue is obtained through simulation according to the output voltage output by the electrode to the internal tissue, the position information of the electrode and the image data of the internal tissue, then the set value of the output voltage is adjusted according to the field intensity or the predicted temperature of the tumor area, and the output voltage is output to the internal tissue through the set value. Thus, the output voltage of the device for inhibiting tumor proliferation by using the electric field in the embodiment of the application can control the temperature of the electrode plate contacting the surface of the user on the premise of keeping the output voltage of the device for inhibiting tumor proliferation by using the electric field, and reduce the shutdown frequency of the device for inhibiting tumor proliferation by using the electric field.
Other advantages of the present application will be explained in more detail in connection with the following description and accompanying drawings.
It should be understood that the foregoing description is only an overview of the technical solutions of the present application so that the technical means of the present application may be more clearly understood and may be implemented in accordance with the content of the specification. The following specific embodiments of the present application are illustrated in order to make the above and other objects, features and advantages of the present application more comprehensible.
Drawings
The advantages and benefits described herein, as well as other advantages and benefits, will become apparent to those of ordinary skill in the art upon reading the following detailed description of the exemplary embodiments. The drawings are only for purposes of illustrating exemplary embodiments and are not to be construed as limiting the application. Also, like reference numerals are used to designate like parts throughout the figures. In the drawings:
fig. 1 is a schematic diagram of an apparatus for suppressing tumor proliferation using an electric field according to an embodiment of the present application;
FIG. 2 is a schematic diagram of a temperature distribution according to an embodiment of the present disclosure;
FIG. 3 is a schematic diagram of another temperature distribution provided in an embodiment of the present application;
FIG. 4 is a flow chart of adjusting the set point of the output voltage according to the embodiment of the present application;
FIG. 5 is a schematic diagram of a set point adjustment of an output voltage according to an embodiment of the present disclosure;
fig. 6 is a schematic diagram of an application environment of a processor according to an embodiment of the present application.
In the drawings, the same or corresponding reference numerals indicate the same or corresponding parts.
Detailed Description
Exemplary embodiments of the present application will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present application are shown in the drawings, it should be understood that the present application may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.
In the description of embodiments of the present application, it should be understood that terms such as "comprises" or "comprising" are intended to indicate that the disclosed features, numbers, steps, acts, components, portions, or combinations thereof, are present in the specification, and do not preclude the presence or addition of one or more other features, numbers, steps, acts, components, portions, or combinations thereof.
Unless otherwise indicated, "/" means or, e.g., A/B may represent A or B; "and/or" herein is merely an association relationship describing an association object, and means that three relationships may exist, for example, a and/or B may mean: a exists alone, A and B exist together, and B exists alone.
The terms "first," "second," and the like are used merely for convenience of description to distinguish between the same or similar technical features, and are not to be construed as indicating or implying a relative importance or quantity of such technical features. Thus, a feature defined by "first," "second," etc. may explicitly or implicitly include one or more such feature. In the description of embodiments of the present application, the term "plurality" means two or more unless otherwise indicated.
In addition, it should be noted that, without conflict, the embodiments and features of the embodiments in the present application may be combined with each other. The present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
As shown in fig. 1, an apparatus for suppressing tumor proliferation using an electric field provided in an embodiment of the present application includes:
the processor 300 is configured to obtain, through simulation, a field intensity of a tumor region in the internal tissue according to an output voltage of the electrode 200 to the internal tissue, position information of the electrode, and image data of the internal tissue, and adjust a set value of the output voltage according to the field intensity, in a process of outputting the alternating voltage by the alternating voltage source;
and/or a processor 300 for obtaining a predicted temperature through simulation according to temperature data, output voltage, position information of the electrode and image data of the tissue in the body in the process of outputting the alternating voltage by the alternating voltage source, and adjusting a set value of the output voltage according to the predicted temperature, wherein the temperature data indicates the temperature of the contact area of the electrode and the skin;
A controller 400 for controlling the alternating voltage source 100 to output a voltage to the internal tissue through the electrode 200 according to a set value.
The term "during the output of the alternating voltage from the alternating voltage source" means the preparation process before the output of the alternating voltage, the output process of the alternating voltage, and the time for switching the direction of the alternating voltage.
It should be noted that, in the embodiment of the present application, the electrode coupled with the capacitor may be located on an electrode patch, and the electrode patch is applied to the surface of the human body. Two electrode patches which are arranged in pairs are adhered to the skin surface of a human body, and the two electrode patches are respectively adhered to the paired positions on two sides of the target area. The two electrodes are respectively connected with the two output ends of the signal output module; the signal output module outputs alternating current to the two electric field patches, an alternating electric field is formed between the two electrodes, and the alternating electric field covers the target area, so that the growth of tumor cells in the target area is inhibited.
The controller controls signal output of the signal output module, including output voltage and/or output current. The device for suppressing tumor proliferation by using an electric field in the embodiment of the application can comprise a sensing component. The sensing assembly includes one or more of a temperature collector, a current sensor, and a voltage sensor. The temperature collector is arranged near the electrode and can be positioned on the electrode patch for collecting temperature data of the contact area of the electrode and the skin. The device for suppressing tumor proliferation using an electric field may further include a current sensor and a voltage sensor. The current sensor is used for collecting the magnitude of the current flowing through the electric field patch; the voltage sensor is used for collecting voltage between the two electric field patches.
The processor in the embodiment of the application can construct an electric field distribution model of the internal tissue according to the output voltage of the electrode to the internal tissue, the position information of the electrode and the image data of the internal tissue. And then determining the field intensity of the tumor area according to the electric field distribution model and the position of the tumor area. The field strength of the tumor region can be calculated in the frequency domain by fourier transformation. In the course of electric field therapy of tumors, the inhibition of tumor cells depends on the strength of the electric field applied to the target location, which is determined by the voltage value output from the alternating voltage source to the electrodes.
The effect of electric field treatment on tumors is directly related to the electric field intensity of the tumor area, however, the electric field intensity of the tumor area cannot be directly measured, i.e. the feedback link of the traditional closed-loop regulation is cut off, and the closed-loop regulation of the electric field intensity of the target area cannot be realized. The utility model provides a be different from traditional technical scheme, utilize the field intensity control tumour electric field therapeutic instrument output of tumour region's that real-time emulation calculation technique calculated, compare in traditional product technique, this case technical scheme can realize the closed-loop control to target area electric field intensity, can make electric field treatment more accurate effective. The published literature data show that the effective electric field intensity for treating tumors is 0.7V/cm-3V/cm. Therefore, after the field intensity of the tumor area is determined, the alternating voltage source can be accurately regulated to output voltage to the internal tissues through the electrode according to the field intensity of the tumor area, so that the temperature of the electrode plate contacting the surface of a user is controlled on the premise that the treatment effect is maintained, namely the field intensity is maintained to be more than 0.7V/cm, and the shutdown frequency of equipment for inhibiting tumor proliferation by using the electric field is reduced.
The tumor region in the embodiment of the present application may be a region determined in advance in image data of an in vivo tissue by an operator, or may be a region determined by a processor or other electronic devices through image recognition, which is not limited herein. The in-vivo tissue in the present application may be the skull or other site of the user, and the embodiments of the present application are not limited herein.
The processor in the embodiment of the application can also obtain the predicted temperature by simulating a plurality of temperature collectors according to the temperature data, the output voltage, the position information of the electrode and the image data of the internal tissues. The predicted temperature may be the temperature of the electrode-skin contact area after a period of time in the future. The processor in the application can calculate the temperature value of the current transient value in the time domain and predict the temperature change in a certain time period in the future, so as to obtain the predicted temperature.
It should be noted that, according to the present application, the heating condition of the internal tissue can be determined according to the output voltage, the position information of the electrode, and the influence data of the internal tissue, so as to predict the predicted temperature after a period of time in the future through the heating condition, the current temperature or the historical temperature in the temperature data, and the like. According to the embodiment of the application, the temperature of the electrode plate contacting the surface area of the user can be controlled according to the predicted temperature on the premise of maintaining the treatment effect, and the shutdown frequency of equipment for inhibiting tumor proliferation by using an electric field is reduced.
In practical application, the method can establish an electrode slice-skull system heating analysis method based on field intensity and according to Joule's law and a biological heat transfer control differential equation, and realizes an electromagnetic heat multi-physical field coupling algorithm model. Compared with an electric field intensity algorithm, a heating algorithm which is based on field intensity and finally needs to be coupled with the field intensity algorithm needs to consider blood flow, heat generation of intracranial tissue metabolic activity, influence of human body temperature regulation and the like in the development process. In technical implementation, the heating simulation is a new physical theory relative to the electric field calculation for solving maxwell's equations, and thermal analysis based on, for example, fourier heat transfer law and energy conservation can be used, and three kinds of boundary conditions need to be considered simultaneously.
In the embodiment of the application, the processor may simulate the temperature of the electrode slice by giving a maximum limit value, and the maximum limit value is also controlled by time after the transient study is completed. The maximum limit may be 39.9 degrees celsius, 38.8 degrees celsius, 41.8 degrees celsius, 40.3 degrees celsius, or other temperatures. Taking the skull of the user as a treatment object as an example, as one possible implementation manner, the processor in the embodiment of the application may obtain the distribution information of the temperature through a comparison algorithm, where the distribution information is shown in fig. 2. In fig. 2, the x-axis and y-axis indicate position coordinates, and the right-hand graph indicates temperature in degrees celsius. As another possible implementation manner, the processor in the embodiment of the present application may obtain the distribution information of the temperature through a finite element calculation algorithm, where the distribution information is shown in fig. 3. The right hand graph in fig. 3 shows temperature in degrees celsius.
It can be seen that, according to the apparatus for suppressing tumor proliferation using an electric field provided in the embodiments of the present application, according to the output voltage output by the electrode to the internal tissue, the position information of the electrode, and the image data of the internal tissue, the field intensity or the predicted temperature of the tumor region in the internal tissue is obtained through simulation, and then, according to the field intensity or the predicted temperature of the tumor region, the set value of the output voltage is adjusted, and the output voltage is output to the internal tissue through the set value. Thus, the output voltage of the device for inhibiting tumor proliferation by using the electric field in the embodiment of the application can control the temperature of the electrode plate contacting the surface of the user on the premise of keeping the output voltage of the device for inhibiting tumor proliferation by using the electric field, and reduce the shutdown frequency of the device for inhibiting tumor proliferation by using the electric field.
In practical application, the application can implant the electric field intensity simulation algorithm module of the tumor area into equipment for inhibiting tumor proliferation by utilizing an electric field. The algorithm module can rapidly calculate the intracranial electric field intensity distribution state and the instantaneous temperature of the contact area of the electrode and the skin according to the peak-to-peak value of the current output voltage of the electrode and forecast the numerical change of the temperature in a future period of time. When the predicted temperature value exceeds the preset temperature threshold value, information is sent to the controller to reduce the peak-peak value of the voltage so as to slow down or inhibit the continuous rising of the scalp temperature, and the algorithm module also recalculates the field intensity of the tumor area and the scalp temperature according to the peak-peak value of the output voltage after stepwise reduction (or slow reduction). The simulation of the predicted temperature is time-continuous, namely, the calculation result of the last step is used as the initial value of the next step of simulation, so that the real simulation of temperature accumulation and heat dissipation is realized. In the continuous operation of the equipment for inhibiting tumor proliferation by using the electric field can be ensured under the dynamic regulation mode, the temperature of the contact area of the electrode and the skin does not exceed a preset temperature threshold, and the actual change form of the temperature is a fluctuation curve which approaches a safe value infinitely in the specified treatment time, so that the continuous action of an effective field intensity area can be realized, and the treatment effect and efficiency are improved.
The technical solution of the present application is described below by way of an example.
As shown in fig. 4, the processor and controller in the present application may be used to perform the following steps.
S201: the processor obtains the field intensity of the tumor area in the in-vivo tissue through simulation according to the output voltage of the electrode to the in-vivo tissue, the position information of the electrode and the image data of the in-vivo tissue.
In an embodiment of the present application, the processor may perform step S201. The processor is specifically used for obtaining the field intensity of a tumor area in the in-vivo tissue through simulation according to the output voltage, the position information of the electrode and the image data of the in-vivo tissue.
S202: the processor obtains the predicted temperature through simulation according to the temperature data, the output voltage, the position information of the electrode and the image data of the in-vivo tissue.
In an embodiment of the present application, the processor may further perform step S202. The processor is also used for obtaining the predicted temperature through simulation according to the temperature data, the output voltage, the position information of the electrode and the image data of the in-vivo tissue.
S203: the controller increases the load and increases the set point of the output voltage.
The controller may increase the load when the field strength is less than a preset field strength threshold, thereby increasing the set point of the output voltage. The controller may also increase the load and increase the set value of the output voltage when the predicted temperature is less than or equal to the preset temperature threshold. Specifically, the controller may continue to increase the load when the temperature is equal to or less than the preset temperature threshold for a prescribed period of time.
S204: the controller reduces the load and lowers the set point of the output voltage.
The method can simultaneously utilize the predicted temperature and the field intensity of the tumor area to judge. In the embodiment of the application, the processor is further configured to obtain, through simulation, field intensity of a tumor area in the internal tissue according to output voltage of the electrode to the internal tissue, position information of the electrode, and image data of the internal tissue, and obtain, through simulation, a predicted temperature according to the temperature data, the output voltage, the position information of the electrode, and the image data of the internal tissue.
When the predicted temperature is greater than the preset temperature threshold, the controller may reduce the load and turn down the set point of the output voltage. When the field intensity of the tumor area is larger than a preset field intensity threshold value and the predicted temperature is smaller than or equal to a preset temperature threshold value, the controller can increase the load to raise the set value of the output voltage.
It should be noted that, due to the limitation of the simulation speed, the conventional simulation method cannot be directly used in combination with the device for inhibiting tumor proliferation by using the electric field in the application, and in the application, the simulation method is to divide the finite element model and simulate only the representative part, so as to improve the simulation speed, and further, the simulation method can be matched with the application scene and used in combination with the device for inhibiting tumor proliferation by using the electric field. As a possible implementation manner, the application can obtain three-dimensional medical image data of a specified area or tissue in the body, and divide the image data to form a multi-layer slice image; the processor is used for obtaining the field intensity of a tumor area in the internal tissue through simulation according to one or more slice images containing a target area or a target tissue, the output voltage of the electrode to the internal tissue and the position information of the electrode in the multi-layer slice image, and adjusting the set value of the output voltage according to the field intensity; and/or a processor for obtaining a predicted temperature through simulation according to the temperature data, the output voltage, the position information of the electrode and the target slice image in the multi-layer slice image, and adjusting a set value of the output voltage according to the predicted temperature. It should be noted that, in the embodiment of the present application, the target slice image may be one slice image of the internal tissue, or may be a plurality of slice images of the internal tissue, which is not limited herein. The determination of the target slice image in the multi-slice image may be predetermined or may be determined in real time according to the position information of the electrode, etc., which is not limited herein.
In one embodiment, for example, the treatment of a tumor in a head includes the steps of obtaining image data of a target region of a body; the image data comprises a multi-layer slice image of the target area; the image data may be obtained by using imaging techniques, such as nuclear magnetic resonance techniques of various sequences, and may specifically include: positron emission computed tomography-magnetic resonance imaging (PET-CT)/magnetic resonance imaging (Magnetic Resonance Imaging, MRI), CT, etc., images of diseased regions of tissue within a human or animal body are obtained to determine lesion areas and/or lesion locations. Selecting a target slice image in the multi-layer slice images; the target slice image is an image with the largest area occupation ratio of the tumor area in the multi-layer slice image. Image segmentation is carried out on the target slice image so as to determine corresponding pixel points of each tissue component in the target slice image; determining electrode pixel points corresponding to the electrode plates in the multi-layer slice image; according to the tissue components corresponding to each pixel point, giving an initial value to the physical and electrical parameters of each pixel point of a pre-constructed field intensity calculation model, carrying out iterative calculation on the field intensity calculation model after giving the initial value under the constraint of boundary conditions of the field intensity calculation model, and determining the electric field intensity mode of each pixel point when the electric field intensity mode of each pixel point calculated by the field intensity calculation model accords with the preset conditions.
The field intensity calculation model is determined by electric field intensity modes of all pixel points, the boundary condition is determined by electric potentials of reference pixel points in all pixel points, the electric field intensity modes of all pixel points are determined by electric potentials of all pixel points, and the reference pixel points comprise at least one of the electrode pixel points and edge pixel points positioned at the edge of a target slice image.
Specifically, after determining the target slice image, the present application may perform image segmentation according to information of each pixel point in the target slice image, so as to obtain a pixel point corresponding to each tissue component determined in the target slice image, and taking the target slice image of the brain as an example, each tissue component may include air, scalp, skull, cerebrospinal fluid, gray matter, white matter, tumor, and the like. Further, different codes can be used for identification in the image segmentation result, for example, the code 0 is used for representing an external air part, the code 1 is used for representing a scalp part, the code 2 is used for representing a skull part, the code 3 is used for representing an internal spinal fluid part, the code 4 is used for representing a gray matter part, the code 5 is used for representing a white matter part, the code 6 is used for representing a tumor part, and the conversion of a slice image from a geometric space to a material space is realized. The whole process avoids the process of solid geometry modeling, thereby simplifying a lot of work.
Specifically, in general, the electrode slice comprises 4 electrode slices, namely two pairs of electrode slices, the electrode slices are distributed in a front-back and left-right mode, each pair of electrode slices can be composed of 18 small electrodes, the embodiment of the application can firstly model the whole outline structure of a biological target area, then model the biological target area to which the electrode slices are attached according to the actual attaching position of the electrode slices, and obtain electrode pixel points corresponding to the electrode slices in the target slice image according to the modeling result and the relative position of the target slice image corresponding to the whole outline of the target area on the three-dimensional space, wherein it is understood that the electrode pixel points are pixel points used for representing the electrode slices in the target slice image, and the position of the electrode pixel points in the target slice image corresponds to the position of the electrode slices in the biological attaching position.
Taking a biological target area as a brain as an example, a position relation between the height of the electrode plate and a target slice image can be established, for example, the target slice image corresponds to the top of the brain, according to the actual placement position and size of the electrode plate, the height information of the electrode plate (or electrode pixel point) in the biological target area relative to the target slice image can be determined, and by further combining the size of the electrode plate, the position coordinate, namely the ordinate, of the electrode plate relative to the target slice image can be obtained, and the relative coordinate of the electrode plate pixel point and the target slice image pixel point is considered when electric field (potential) simulation is carried out.
The field intensity calculation model of the embodiment of the present application may be determined by an electric field intensity model of each pixel point, that is, the field intensity calculation model is used to obtain an electric field intensity model of each pixel point, the solving area includes all pixel points in the target slice image, it may be understood that, to solve the electric field intensity model of each pixel point, it is necessary to obtain the electric field intensity of each pixel point, calculation of the field intensity calculation model further involves constraint of boundary conditions, where the boundary conditions of the embodiment of the present application are related to electric potentials of reference pixel points in each pixel point, that is, the boundary conditions are used to constrain electric potentials of the reference pixel points, and the reference pixel points of the embodiment of the present application include at least one of the electrode pixel points and edge pixel points located at an edge of the target slice image, where constraint conditions related to the edge pixel points are also referred to as external boundary conditions. Wherein "outside", i.e. outside the biological target area, the embodiments of the present application consider that the outside of the biological target area is a homogeneous air medium without a field source, and the boundary condition related to the electrode pixel is called Dirichlet boundary condition.
According to the method, the initial value is given to the physical and electrical parameters of each pixel point in the field intensity calculation model, iterative calculation is carried out on the field intensity calculation model after the initial value is given on the constraint line of the boundary condition, the calculation result of each iteration is the electric field intensity model of each pixel point, whether the electric field intensity model meets the preset condition is judged, if yes, iteration is stopped, if not, iteration is continued, the electric field intensity of each pixel point obtained in the previous iteration can be utilized to obtain the electric field intensity of each pixel point in the current iteration when the iteration is carried out, and then the electric field intensity modeling of each pixel point is obtained based on the electric field intensity of each pixel point in the current iteration.
According to the embodiment of the application, firstly, the image of the target area of the organism is obtained, the target slice image is obtained from the image, namely, the slice image of the specific layer is processed, in the embodiment, the specific layer refers to a slice image with the largest tumor area ratio, the pixel points corresponding to each tissue component are determined through the slice image of the specific layer, when the initial value is given to the field intensity calculation model, the pixel points of different tissue components are directly and rapidly assigned, the conversion from the geometric space to the material space is realized, the whole process avoids the process of solid geometric modeling, and therefore a large amount of work is simplified.
In addition, the embodiment of the application directly uses the regular coordinate positions read by the image to replace grid division, and has the advantages that only coordinate points are arranged without grid surfaces, the problem of grid distortion is avoided, and the occupied CPU memory is greatly reduced.
For the density condition of the coordinate points, the embodiment of the application can directly reserve the pixel precision achieved by the image. In modeling of the electrode plate, the electrode plate is simplified into boundary conditions corresponding to the scalp applying position (electrode pixel points in a two-dimensional image) by the method, the modeling work of the three-dimensional geometry of the electrode plate entity is omitted, only the position of the scalp coordinate point to which the electrode plate is applied is required to be determined, and the position of the electrode plate can be changed by modifying the coordinate point, so that the position of the electrode plate can be quickly changed. That is, the core of the embodiment of the present application is to use coordinate points instead of grids. The electric field intensity module of the whole solving area is calculated through a finite difference method matching iterative algorithm, the algorithm converts a complex partial differential equation into differential operation among coordinate points, the calculating efficiency can be greatly improved, and the iterative algorithm can ensure that a calculating result meets the required precision requirement through a preset calculating error.
Through practical verification, the method provided by the embodiment of the application can be realized through portable programming of platforms such as C++, and the like, only the electric field intensity of a target is calculated, and the time for finishing single operation of a main program is only about 4s, so that the voltage is rapidly simulated in the process of implementing electric field treatment.
In some possible embodiments, the device for inhibiting tumor proliferation using an electric field may comprise a plurality of pairs of electrodes. Correspondingly, the processor is further used for obtaining electrode temperature distribution information through simulation according to temperature data, output voltage, electrode position information and in-vivo tissue image data of each electrode in the plurality of pairs of electrodes, and the electrode temperature distribution information comprises the predicted temperature of each electrode. The temperature data of each electrode of the plurality of electrodes and the position information of the output voltage electrode can be input into a model built by image data of internal tissues together, so that the accuracy of the predicted temperature of each electrode can be improved to a certain extent. When the field intensity of the tumor area is calculated, the field intensity of the tumor area in the in-vivo tissue can be obtained through simulation according to the output voltage of each electrode in the plurality of electrodes, the position information of the electrodes and the image data of the in-vivo tissue, and the embodiment of the application is not repeated here.
The applicant has found that when the output current through the electrode to the tissue in the body is less than the current threshold, the temperature of the electrode in the area of contact with the skin is relatively stable and the frequency of shutdown of the device for inhibiting tumour proliferation by means of the electric field is relatively low. In the examples of the application, the temperature property of the temperature is maintained. The processor is further configured to control an output current of the alternating voltage source through the electrode to the tissue in the body to be less than a current threshold.
In the embodiment of the application, when the set value of the output voltage is adjusted according to the combination of the predicted temperature and the field intensity of the tumor area, the judgment priority of the predicted temperature is higher than the judgment of the field intensity of the tumor area. The field strength may activate the controller to increase the load when the preset field strength threshold is not reached, but must be constrained by the preset temperature threshold. Under the condition that the temperature does not exceed the preset temperature threshold, the field intensity can be further increased after the field intensity reaches the preset field intensity threshold, so that the treatment efficiency is improved.
The technical solution of the present application is described below by way of another example.
In the embodiment of the application, the processor may obtain, through simulation, the field intensity of the tumor area in the in-vivo tissue according to the current output voltage output by the electrode to the in-vivo tissue, the position information of the electrode, and the image data of the in-vivo tissue, and determine the first voltage value according to the field intensity. The first voltage value is positively correlated with the difference between the field strength and a preset field strength threshold. The processor may determine a second voltage value based on the present current output by the electrode; the set point is determined from the greater of the first voltage value and the second voltage value. If the second voltage value is smaller than the first voltage value, the output voltage of the electrode is smaller than the minimum voltage corresponding to the effective output of the tumor proliferation suppressing device by the electric field, so that the output voltage of the electrode can be readjusted according to the first voltage value. If the second voltage value is greater than the first voltage value, it is indicated that the output voltage of the electrode is greater than the corresponding minimum voltage for the device effective in suppressing tumor proliferation using the electric field. The larger the output voltage of the electrode, the better the therapeutic effect of the device for suppressing tumor proliferation by the electric field, so that the output voltage of the second voltage value can be continuously maintained at this time.
In the embodiment of the present application, if the output current of the electrode is greater than the current threshold, the user may be endangered. Thus devices that utilize an electric field to inhibit tumor proliferation may be shut down when the output current is greater than the current threshold. In order to avoid the equipment halt which is caused by overlarge output current and utilizes the electric field to inhibit tumor proliferation, the processor is also used for determining a third voltage value according to a preset current threshold value; taking the smaller value of the third voltage value and the second voltage value as a first target voltage value; the set point is determined from the greater of the first target voltage value and the first voltage value.
As a possible implementation, the processor is further configured to determine a fourth voltage value based on a temperature of the electrode in contact with the skin; determining a fifth voltage value according to the temperature threshold; taking the smaller value of the fourth voltage value and the fifth voltage value as a second target voltage value; taking the smaller value of the first target voltage value and the second voltage value as a third target voltage value; and adjusting the set value of the output voltage according to the smaller value of the second target voltage value and the third target voltage value. When the fourth voltage value is greater than the fifth voltage value, it is explained that the temperature of the electrode skin contact area may be greater than the temperature threshold value at this time, and in order to control the temperature of the electrode skin contact area, the probability of stopping the apparatus for suppressing tumor proliferation by using the electric field is reduced, and the set value of the output voltage may be adjusted according to the third target voltage value. When the fourth voltage value is smaller than the fifth voltage value, which indicates that the temperature of the electrode skin contact area is smaller than the temperature threshold value, the set value of the output voltage can be adjusted according to the fourth target voltage value.
According to the method and the device, the set value of the output voltage is adjusted according to the smaller value of the second target voltage value and the third target voltage value, and the temperature of the electrode plate contacting the surface of a user can be controlled on the premise that the output voltage of the equipment for inhibiting tumor proliferation by using the electric field is kept, so that the shutdown frequency of the equipment for inhibiting tumor proliferation by using the electric field is reduced.
It should be noted that, in the embodiment of the present application, the first voltage value, the second voltage value, the third voltage value, the fourth voltage value, the fifth voltage value, the first target voltage value, the second target voltage value, and the third target voltage value are not limited to the voltage values, and the values may be voltages, currents, or other unitless intermediate values.
Referring to fig. 5, a schematic diagram of setting adjustment of an output voltage according to an embodiment of the present application is shown.
As shown in fig. 5, the processor is specifically configured to perform simulation through the simulation module according to the current output voltage Ug output by the electrode to the internal tissue, the position information of the electrode, and the image data of the internal tissue, to obtain the field intensity of the tumor area in the internal tissue, and determine the first voltage value U1 according to the field intensity. The processor in the embodiment of the application can determine the second voltage value U2 by processing the current Ig output by the electrode through the processor module. The processor in the present application may also determine the third voltage value U3 by processing the preset current threshold IL by the processor module. The processor may process the temperature Tg of the electrode-skin contact area by the processor module to obtain a fourth voltage value U4. The processor may obtain the fifth voltage value U5 by the processor module processing the temperature threshold Tgd.
The processor takes the smaller of the third voltage value U3 and the second voltage value U2 as the first target voltage value Ut1. The smaller of the fourth voltage value U4 and the fifth voltage value U5 is taken as the second target voltage value Ut2. The larger of the first target voltage value Ut1 and the first voltage value U1 is taken as a third target voltage value Ut3. The set-point signal UK is determined from the smaller of the second target voltage value Ut2 and the third target voltage value Ut3.
In summary, according to the apparatus for suppressing tumor proliferation by using an electric field provided in the embodiments of the present application, according to the output voltage output by the electrode to the internal tissue, the position information of the electrode, and the image data of the internal tissue, the field intensity or the predicted temperature of the tumor region in the internal tissue is obtained through simulation, and then the set value of the output voltage is adjusted according to the field intensity or the predicted temperature of the tumor region, and the output voltage is output to the internal tissue through the set value. Thus, the output voltage of the device for inhibiting tumor proliferation by using the electric field in the embodiment of the application can control the temperature of the electrode plate contacting the surface of the user on the premise of keeping the output voltage of the device for inhibiting tumor proliferation by using the electric field, and reduce the shutdown frequency of the device for inhibiting tumor proliferation by using the electric field.
In the description of the present specification, descriptions with reference to the terms "some possible embodiments," "some embodiments," "examples," "specific examples," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiments or examples is included in at least one embodiment or example of the present application, and that the above terms do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the various embodiments or examples described in this specification and the features of the various embodiments or examples may be combined and combined by those skilled in the art without contradiction.
With respect to the method flowcharts of the embodiments of the present application, certain operations are described as distinct steps performed in a certain order. Such a flowchart is illustrative and not limiting. Some steps described herein may be grouped together and performed in a single operation, or may be divided into multiple sub-steps and may be performed in an order different than that shown herein. The various steps illustrated in the flowcharts may be implemented in any manner by any circuit structure and/or tangible mechanism (e.g., by software running on a computer device, hardware (e.g., processor or chip implemented logic functions), etc., and/or any combination thereof).
Although the operations of the methods of the present application are described in a particular order in the figures, this does not require or imply that the operations must be performed in the particular order or that all of the illustrated operations be performed in order to achieve desirable results. In addition, some steps may be omitted, multiple steps may be combined into one step to be performed, and/or one step may be decomposed into multiple sub-steps to be performed.
It will be appreciated by those skilled in the art that in the methods described in the above embodiments, the written order of steps does not imply a strict order of execution, and that the specific order of execution of the steps should be determined by its function and possible inherent logic.
According to the above device for suppressing tumor proliferation by using an electric field, the present application also provides a processor.
As shown in fig. 6, the processor is applied to an apparatus for suppressing tumor proliferation using an electric field, the apparatus further comprising: an alternating voltage source 100, at least one pair of electrodes 200, and a controller 300;
the electrodes are used for being attached to the body surface of a user, the alternating voltage source 100 is electrically connected with the electrodes, and the alternating voltage source 100 is used for applying alternating voltage to internal tissues through the electrodes 200;
the processor 300 is used for obtaining the field intensity of a tumor area in the internal tissue through simulation according to the output voltage of the electrode 200 to the internal tissue, the position information of the electrode and the image data of the internal tissue, and adjusting the set value of the output voltage according to the field intensity;
And/or a processor 300 for obtaining a predicted temperature through simulation according to the temperature data, the output voltage, the position information of the electrode and the image data of the tissue in the body, and adjusting a set value of the output voltage according to the predicted temperature, wherein the temperature data indicates the temperature of the contact area of the electrode 200 and the skin;
a controller 400 for controlling the alternating voltage source to output a voltage to the internal tissue through the electrode 200 according to the set value.
In some possible embodiments, the processor is specifically configured to obtain, through simulation, a field intensity of a tumor region in the in-vivo tissue according to the output voltage, the position information of the electrode, and the image data of the in-vivo tissue;
the controller is used for adjusting the set value of the output voltage when the field intensity is smaller than a preset field intensity threshold value.
In some possible embodiments, the processor is specifically configured to obtain the predicted temperature through simulation according to the temperature data, the output voltage, the position information of the electrode, and the image data of the tissue in the body;
the controller is used for adjusting the set value of the output voltage when the predicted temperature is smaller than or equal to the preset temperature threshold value, and adjusting the set value of the output voltage when the predicted temperature is larger than the preset temperature threshold value.
In some possible embodiments, the processor is specifically configured to obtain, through simulation, a field intensity of a tumor area in the in-vivo tissue according to an output voltage of the electrode to the in-vivo tissue, position information of the electrode, and image data of the in-vivo tissue, and obtain, through simulation, a predicted temperature according to the temperature data, the output voltage, the position information of the electrode, and the image data of the in-vivo tissue;
The controller is used for adjusting the set value of the output voltage when the field intensity of the tumor area is larger than a preset field intensity threshold value and the predicted temperature is smaller than or equal to a preset temperature threshold value.
In some possible embodiments, the image data of the in vivo tissue comprises image data of the in vivo tissue comprising a multi-layer target slice image; the processor is used for obtaining the field intensity of a tumor area in the internal tissue through simulation according to a target slice image in the multi-layer slice image, the output voltage of the electrode to the internal tissue and the position information of the electrode, and adjusting the set value of the output voltage according to the field intensity; and/or a processor for obtaining a predicted temperature through simulation according to the temperature data, the output voltage, the position information of the electrode and the target slice image in the multi-layer slice image, and adjusting a set value of the output voltage according to the predicted temperature.
In some possible embodiments, the apparatus further comprises: a temperature collector;
and the temperature collector is used for collecting temperature data of the contact area of the electrode and the skin.
In some possible embodiments, the device comprises a plurality of pairs of electrodes;
and the processor is also used for obtaining electrode temperature distribution information through simulation according to the temperature data, the output voltage, the position information of the electrodes and the image data of the internal tissues of each electrode in the plurality of pairs of electrodes, wherein the electrode temperature distribution information comprises the predicted temperature of each electrode.
In some possible embodiments, the processor is specifically configured to obtain, through simulation, a field intensity of a tumor area in the in-vivo tissue according to a current output voltage output by the electrode to the in-vivo tissue, position information of the electrode, and image data of the in-vivo tissue, and determine a first voltage value according to the field intensity;
determining a second voltage value according to the current output by the electrode;
the set point is determined from the greater of the first voltage value and the second voltage value.
In some possible embodiments, the processor is further configured to determine a third voltage value according to a preset current threshold;
taking the smaller value of the third voltage value and the second voltage value as a first target voltage value;
the set point is determined from the greater of the first target voltage value and the first voltage value.
In some possible embodiments, the processor is further configured to determine a fourth voltage value based on a temperature of the electrode in contact with the skin;
determining a fifth voltage value according to the temperature threshold;
taking the smaller value of the fourth voltage value and the fifth voltage value as a second target voltage value;
taking the larger value of the first target voltage value and the first voltage value as a third target voltage value;
and determining the set value according to the smaller value of the second target voltage value and the third target voltage value.
The beneficial effects of the embodiments of the present application are similar to those of the above-described embodiments of the apparatus for inhibiting tumor proliferation by using an electric field, and will not be described herein.
While the spirit and principles of the present application have been described above with reference to several embodiments, it should be understood that the application is not limited to the particular embodiments disclosed nor does the division of aspects mean that features in these aspects cannot be combined. The application is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims.
Claims (20)
1. An apparatus for inhibiting tumor proliferation using an electric field, comprising: an alternating voltage source, at least one pair of electrodes, a processor, and a controller;
the electrode is used for being attached to the body surface of a user, the alternating voltage source is electrically connected with the electrode, and the alternating voltage source is used for applying alternating voltage to internal tissues through the electrode;
the image data of the in-vivo tissue comprises a multi-layer target slice image;
the processor is used for assigning values to the pixel points of the target slice images according to one layer of target slice images in the multi-layer slice images, the output voltage of the electrodes to the internal tissues and the position information of the electrodes in the process of outputting alternating voltage by the alternating voltage source, obtaining the field intensity of a tumor area in the internal tissues through simulation, and adjusting the set value of the output voltage according to the field intensity;
And/or the processor is used for assigning a value to a pixel point of the target slice image according to temperature data, output voltage, position information of the electrode and one layer of target slice image in the multi-layer slice image in the process of outputting alternating voltage by the alternating voltage source, obtaining a predicted temperature through simulation, and adjusting a set value of the output voltage according to the predicted temperature;
the controller is used for controlling the alternating voltage source to output voltage to internal tissues through the electrode according to the set value.
2. The apparatus of claim 1, wherein the processor is specifically configured to obtain, by simulation, a field intensity of a tumor region in the in-vivo tissue based on the output voltage, the positional information of the electrode, and the image data of the in-vivo tissue during the output of the alternating voltage by the alternating voltage source; the controller is used for adjusting the set value of the output voltage when the field intensity is smaller than a preset field intensity threshold value.
3. The apparatus according to claim 1, wherein the processor is specifically configured to obtain, during the outputting of the alternating voltage by the alternating voltage source, a predicted temperature by simulation based on the temperature data, the output voltage, the positional information of the electrode, and the image data of the in-vivo tissue;
The controller is used for adjusting the set value of the output voltage when the predicted temperature is smaller than or equal to a preset temperature threshold value, and adjusting the set value of the output voltage when the predicted temperature is larger than the preset temperature threshold value.
4. The apparatus according to claim 1, wherein the processor is specifically configured to obtain, during the outputting of the alternating voltage by the alternating voltage source, a field intensity of a tumor region in the in-vivo tissue by simulation based on the output voltage of the electrode to the in-vivo tissue, the position information of the electrode, and the image data of the in-vivo tissue, and obtain, by simulation, a predicted temperature based on the temperature data, the output voltage, the position information of the electrode, and the image data of the in-vivo tissue;
the controller is used for adjusting the set value of the output voltage when the field intensity of the tumor area is larger than a preset field intensity threshold value and the predicted temperature is smaller than or equal to a preset temperature threshold value.
5. The apparatus of claim 1, wherein the apparatus further comprises: a temperature collector;
the temperature collector is used for collecting temperature data of the contact area between the electrode and the skin.
6. The apparatus of claim 1, wherein the apparatus comprises a plurality of pairs of electrodes;
The processor is further configured to obtain electrode temperature distribution information through simulation according to temperature data, output voltage, position information of each electrode in the plurality of pairs of electrodes and image data of the in-vivo tissue in the process of outputting alternating voltage by the alternating voltage source, where the electrode temperature distribution information includes predicted temperature of each electrode.
7. The apparatus of claim 1, wherein the processor is further configured to control an output current of the alternating voltage source through the electrode to the tissue in the body to be less than a current threshold during the output of the alternating voltage from the alternating voltage source.
8. The device according to claim 1, wherein the processor is specifically configured to obtain, through simulation, a field intensity of a tumor region in the in-vivo tissue according to a current output voltage output by the electrode to the in-vivo tissue, position information of the electrode, and image data of the in-vivo tissue, and determine a first voltage value according to the field intensity, where the first voltage value is positively correlated with a difference between the field intensity and a preset field intensity threshold;
determining a second voltage value according to the current output by the electrode;
And determining the set value according to the larger value of the first voltage value and the second voltage value.
9. The apparatus of claim 8, wherein the processor is further configured to determine a third voltage value based on a preset current threshold;
taking the smaller value of the third voltage value and the second voltage value as a first target voltage value;
and determining the set value according to the larger value of the first target voltage value and the first voltage value.
10. The apparatus of claim 9, wherein the processor is further configured to determine a fourth voltage value based on a temperature of the electrode in contact with the skin;
determining a fifth voltage value according to the temperature threshold;
taking the smaller value of the fourth voltage value and the fifth voltage value as a second target voltage value;
taking the larger value of the first target voltage value and the first voltage value as a third target voltage value;
and determining the set value according to the smaller value of the second target voltage value and the third target voltage value.
11. The apparatus of claim 1, wherein the tumor region is a region determined in advance in image data of the in vivo tissue.
12. A processor for use in an apparatus for inhibiting tumor proliferation using an electric field, the apparatus further comprising: an alternating voltage source, at least one pair of electrodes, and a controller;
the electrode is used for being attached to the body surface of a user, the alternating voltage source is electrically connected with the electrode, and the alternating voltage source is used for applying alternating voltage to internal tissues through the electrode;
the image data of the in-vivo tissue comprises a multi-layer target slice image;
the processor is used for assigning values to the pixel points of the target slice images according to one layer of target slice images in the multi-layer slice images, the output voltage of the electrodes to the internal tissues and the position information of the electrodes in the process of outputting alternating voltage by the alternating voltage source, obtaining the field intensity of a tumor area in the internal tissues through simulation, and adjusting the set value of the output voltage according to the field intensity;
and/or the processor is used for assigning a value to a pixel point of the target slice image according to temperature data, output voltage, position information of the electrode and one layer of target slice image in the multi-layer slice image, obtaining a predicted temperature through simulation, and adjusting a set value of the output voltage according to the predicted temperature;
The controller is used for controlling the alternating voltage source to output voltage to internal tissues through the electrode according to the set value.
13. The processor of claim 12, wherein the processor is specifically configured to obtain, during outputting of the alternating voltage by the alternating voltage source, a field intensity of a tumor region in the in-vivo tissue by simulation based on the output voltage, the positional information of the electrode, and the image data of the in-vivo tissue;
the controller is used for adjusting the set value of the output voltage when the field intensity is smaller than a preset field intensity threshold value.
14. The processor of claim 12, wherein the processor is specifically configured to obtain, during the outputting of the alternating voltage by the alternating voltage source, a predicted temperature by simulation based on the temperature data, the output voltage, the positional information of the electrode, and the image data of the in-vivo tissue;
the controller is used for adjusting the set value of the output voltage when the predicted temperature is smaller than or equal to a preset temperature threshold value, and adjusting the set value of the output voltage when the predicted temperature is larger than the preset temperature threshold value.
15. The processor according to claim 12, wherein the processor is specifically configured to obtain, during the outputting of the alternating voltage by the alternating voltage source, a field intensity of a tumor region in the in-vivo tissue by simulation based on the output voltage of the electrode to the in-vivo tissue, the position information of the electrode, and the image data of the in-vivo tissue, and obtain the predicted temperature by simulation based on the temperature data, the output voltage, the position information of the electrode, and the image data of the in-vivo tissue;
The controller is used for adjusting the set value of the output voltage when the field intensity of the tumor area is larger than a preset field intensity threshold value and the predicted temperature is smaller than or equal to a preset temperature threshold value.
16. The processor of claim 12, wherein the device further comprises: a temperature collector;
the temperature collector is used for collecting temperature data of the contact area between the electrode and the skin.
17. The processor of claim 12, wherein the device comprises a plurality of pairs of electrodes;
the processor is further configured to obtain electrode temperature distribution information through simulation according to temperature data, output voltage, position information of each electrode in the plurality of pairs of electrodes and image data of the in-vivo tissue in the process of outputting alternating voltage by the alternating voltage source, where the electrode temperature distribution information includes predicted temperature of each electrode.
18. The processor according to claim 12, wherein the processor is specifically configured to obtain, through simulation, a field intensity of a tumor region in the in-vivo tissue according to a current output voltage output by the electrode to the in-vivo tissue, position information of the electrode, and image data of the in-vivo tissue, and determine a first voltage value according to the field intensity, where the first voltage value is positively correlated with a difference between the field intensity and a preset field intensity threshold;
Determining a second voltage value according to the current output by the electrode;
and determining the set value according to the larger value of the first voltage value and the second voltage value.
19. The processor of claim 18, wherein the processor is further configured to determine a third voltage value based on a preset current threshold during output of the alternating voltage by the alternating voltage source;
taking the smaller value of the third voltage value and the second voltage value as a first target voltage value;
and determining the set value according to the larger value of the first target voltage value and the first voltage value.
20. The processor of claim 19, wherein the processor is further configured to determine a fourth voltage value based on a temperature of the electrode in contact with the skin during output of the alternating voltage from the alternating voltage source;
determining a fifth voltage value according to the temperature threshold;
taking the smaller value of the fourth voltage value and the fifth voltage value as a second target voltage value;
taking the larger value of the first target voltage value and the first voltage value as a third target voltage value;
and determining the set value according to the smaller value of the second target voltage value and the third target voltage value.
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