WO2020009306A1

WO2020009306A1 - Electric field cancer treatment device and method using optimization algorithm

Info

Publication number: WO2020009306A1
Application number: PCT/KR2019/002009
Authority: WO
Inventors: 윤명근; 성지원; 서재현
Original assignee: 고려대학교 산학협력단; 주식회사 필드큐어
Priority date: 2018-07-03
Filing date: 2019-02-20
Publication date: 2020-01-09

Abstract

The present invention relates to an electric field cancer treatment device and method using an optimization algorithm, the electric field cancer-treating treatment device enabling the treatment of a tumor by applying electric fields to the tumor and normal tissues of a patient by using at least one pair of electrode pads having a plurality of electrodes. The electric field cancer-treating treatment device comprises: an image classification unit for classifying, by organ, at least one organ in a captured image of a patient; and an electric field optimization unit for, on the basis of a classified tumor and normal tissues, calculating the number and positions of electrodes being applied and arranging same on electrode pads having a predetermined size, and determining mutually different voltage levels for the calculated electrodes. According to the present invention, when electric fields applied to the respective electrodes are adjusted by using an optimization algorithm, and the electric fields are transferred to the inside of a human body, mutually different electric fields may be applied to the tumor and the normal tissues, and thus the level of the electric field transferred to the normal tissues may be relatively lower than the level of the electric field transferred to the tumor, and thus a risk of treatment side effects may be reduced, and thus the treatment success rate may be increased.

Description

Electric cancer treatment device and method using optimization algorithm

The present invention relates to an electric field cancer treatment apparatus and method using an optimization algorithm, and more specifically, to the electric field strength applied to the patient's body tumor prescribed or more, the electric field strength to be delivered to normal tissues to minimize the It relates to an electric field cancer treatment apparatus and method using an optimization algorithm that can optimize the size.

Cancer treatment techniques using electromagnetic waves are treated by removing tumors on different principles according to treatment frequency bands. The area around 10 ¹⁰ MHz is a frequency band where X-rays appear and is treated with the principle of breaking and destroying DNA double helix of cancer cells. The electromagnetic wave near 10 MHz is treated with the principle of generating heat in human tumor and removing it.

Tumor Treating Fields (TTFields) is a technology that treats tumors by delaying cell division and kills them. It is a cancer treatment technique that is receiving great attention as it is being treated at 1000 treatment centers around the world.

Since the above technique has a great effect on dividing cells, it is known that the effects on normal cells, which are very slow or rarely divide compared to tumors, are insignificant. It is insignificant and there are few specific studies on the effect of electric fields on each major organ in the body. It also has a potential risk for side effects that have not yet emerged since they were less than 10 years old in practice.

In the current treatment, considering the above-mentioned problems, the treatment is performed by selecting the position of the electrode that is capable of delivering the maximum electric field to the tumor and delivering the minimum to the normal tissue, but unnecessarily normal because the same voltage is applied to the electrodes. An electric field can be transmitted to the tissue.

Therefore, the present invention relates to a method and apparatus for treating an electric field by further reducing an electric field unnecessarily transmitted to normal tissue by adjusting not only the position of the electrode but also the voltage applied to each electrode through an optimization algorithm.

It is an object of the present invention to apply to more than the intensity of the electric field prescribed to the patient's body tumor, electric field cancer treatment apparatus and method using an optimization algorithm that can optimize the size of the electric field to minimize the electric field strength delivered to normal tissue To provide.

The object of the present invention is not limited to the above-mentioned object, and other objects that are not mentioned will be clearly understood by those skilled in the art from the following description.

In order to achieve the above object, the electric field cancer treatment apparatus for treating a tumor by applying an electric field to a tumor and normal tissue of the patient using a pair of electrode pads having a plurality of electrodes according to an embodiment of the present invention An image classification unit classifying at least one or more organs in the captured image of each patient for each organ; And an electric field optimizer configured to calculate the number and positions of electrodes applied based on the classified tumors and the normal tissues and arrange them on electrode pads having a predetermined size, and determine voltage magnitudes of different magnitudes on the calculated electrodes. .

Here, the electric field optimizer may calculate the voltage to be applied to the plurality of electrodes in consideration of at least one or more of the type of tumor, the location of the tumor, and the boundary state with normal tissue.

Here, the electric field optimizer may calculate the voltage level of the electrode to be applied to the tumor with a prescribed electric field strength or more, and to be delivered to the normal organs at a minimum.

Here, the electric field optimizer may set the limit electric field value according to the importance of the long term, so that the electrode may be transmitted below the preset limit electric field value.

Here, the electric field optimizer may include an objective function selected using at least one or more of the electric field strength delivered to the tumor or the normal organ, the weight for each normal organ, and the limit electric field value.

Here, the pair of electrode pads may be formed with one surface ground of the pair.

Electric field cancer treatment method for treating a tumor by applying an electric field to the tumor and normal tissue of the patient using a pair of electrode pads having a plurality of electrodes according to an embodiment of the present invention based on the image image of the patient Calling the image to classify the video image for each organ; Through the electric field optimizer, the number and positions of electrodes are arranged on electrode pads of a predetermined size based on the patient's tumor and the boundary state between the tumor and normal tissues, and the magnitude of voltage applied to the plurality of electrodes is calculated to calculate at least one or more treatments. Developing a plan; Analyzing and evaluating the established treatment plan; And applying a voltage to the plurality of electrodes under optimal conditions of the analyzed treatment plan to treat the treatment.

Here, the electric field optimizer may calculate the magnitude of the electrode voltage that can be delivered to the tumor at the same time as the prescription electric field or more.

Here, the voltage and frequency applied to the electrodes are each within 0V to 150V, and may be formed with a value between 100 and 300kHz.

Here, the magnitude of the voltage applied to the electrode may be determined using at least one of the magnitude of the prescription electric field applied to the tumor, the weight for each organ, and a predetermined limit electric field value.

The electric field cancer treatment apparatus and method using the optimization algorithm according to the present invention by adjusting the voltage applied to each electrode by using an optimization algorithm to transmit a different electric field in the body, by applying a different electric field to the tumor and normal tissue, By reducing the size of the electric field delivered to normal tissues relative to the tumor, the risk of treatment side effects can be reduced, thereby increasing the probability of treatment success.

The effects of the present invention are not limited to the above-mentioned effects, and other effects not mentioned will be clearly understood by those skilled in the art from the following description.

1 is a conceptual diagram of an electric field cancer treatment apparatus using an optimization algorithm according to an embodiment of the present invention.

Figure 2 is a conceptual diagram showing the arrangement of the electric field cancer treatment device electrode according to an embodiment of the present invention.

3 is a flow chart of the electric field cancer treatment method using an optimization algorithm according to an embodiment of the present invention.

4 and 5 are simulation comparison diagrams comparing the conventional technology with the electric field cancer treatment apparatus using an optimization algorithm according to an embodiment of the present invention.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. In this case, the same components in the accompanying drawings are to be noted with the same reference numerals as possible. In addition, detailed descriptions of well-known functions and configurations that may blur the gist of the present invention will be omitted. For the same reason, in the accompanying drawings, some components are exaggerated, omitted or schematically illustrated.

In addition, throughout the specification, when a part is said to "include" a certain component, it means that it may further include other components, except to exclude other components unless specifically stated otherwise. In addition, throughout the specification, "on" means to be located above or below the target portion, and does not necessarily mean to be located above the gravity direction.

1 is a conceptual diagram of an electric field cancer treatment apparatus using an optimization algorithm according to an embodiment of the present invention, Figure 2 is a conceptual diagram showing the arrangement of the electric field cancer treatment device electrode according to an embodiment of the present invention.

1 to 2, an electric field cancer treatment apparatus using an optimization algorithm according to an embodiment of the present invention is to treat a tumor by applying a voltage to form an electric field in a tumor and normal tissue of a patient. The electrode pad 110, the image classifying unit 120 and the electric field optimizer 130 is configured.

The pair of electrode pads 110 includes a plurality of electrodes 111, and the electrodes 111 may be arranged in various ways according to the shape of the electrode pad 110. Although the electrode 111 has been described as being arranged in a square matrix of 3 × 3 as shown in FIG. 2 as an example, the number and spacing, etc. can be variously modified through the electric field optimizer 130 to be described later, its shape and arrangement The form is not limited to FIG. 2. In addition, although the electrode pad 110 is illustrated as having two pairs, the electrode pad 110 may be added or reduced depending on the treatment condition of the patient.

In this way, by varying the size of the frequency and voltage applied by variously forming the array shape of the electrode 111 can change the size of the electric field delivered to the tumor and normal tissue and the patient with the tumor and normal tissue Effective treatment can be provided in consideration of boundary conditions and the like. In this case, the pair of electrode pads 110 may be formed with one surface of the pair as the ground (G).

The image classification unit 120 serves to classify at least one or more organs in each image of the captured patient. The image image may be an MRI or CT image. MRI or CT is taken with various organs, including tumors. At this time, the image classification unit 120 classifies the plurality of organs photographed by each organ, and determines the separation distance and the positional relationship between the normal tissue and the tumor. The image classifier 120 automatically classifies the organs according to organs or sets a boundary part for each organ according to a user definition, and reconstructs each image into three-dimensional images for each organ to clearly distinguish the positional relationship of each organ. The data may be applied to adjust the size of the pair of electrode pads 110 or the arrangement of the electrodes.

The electric field optimizer 130 calculates the number and positions of electrodes applied based on the classified tumor and normal tissue, arranges them on the electrode pad 110 of a predetermined size, and determines voltages of different sizes on the calculated electrodes. do. That is, the electric field optimizer 130 calculates the magnitude of the voltage applied to the electrode in consideration of the classified tumor, normal tissue, and the state of the tumor.

Therefore, the electric field optimizer 130 may calculate the magnitude of the voltage applied to the electrode in consideration of at least one or more of the type of tumor to be treated, the location of the tumor, and the boundary state between the tumor and normal tissue. At this time, the electric field optimizer 130 sets the electrode weight as a variable, and separates the electrode to be applied to the voltage and the electrode to be formed of the ground among the plurality of electrodes, the plurality of electrodes can be set differently according to the type of tumor have. For example, in the case of gyomo-sejong, 200kHz, and in the case of lung cancer, it is set to 150kHz to calculate the final electrode weight and voltage of each electrode.

Therefore, when the electric field in the body is controlled to transmit the electric field, different electric fields are applied to the tumor and the normal tissue, thereby reducing the risk of treatment side effects by making the size of the electric field delivered to the normal tissue relatively smaller than the tumor. It can increase the probability of treatment success.

The electric field optimizer 130 may include an objective function selected using at least one or more of electric field strength, normal organ weights, and limit electric field values transmitted to a tumor or normal organ. In addition, the electric field optimizer 130 may set the limit electric field value according to the importance of the long-term, so that the electrode is delivered to the preset limit electric field value or less. Here, the limit electric field means the range of the electric field is set so that more than the predetermined electric field strength is transmitted to the normal organ.

The objective function is to adjust the intensity of the electric field so that the minimum electric field is applied to the main organs of normal tissues when an electric field of more than the prescribed electric field is applied to the tumor. Here, the prescription electric field is the size of the electric field to be delivered over a certain intensity to the total volume of the patient tumor during the treatment of the electric field, the limit electric field is the size of the electric field to be delivered below a certain field strength to the total volume of normal organs.

For example, during the electric field treatment, the doctor applies the strength of the prescribed electric field to the tumor at 1.5 V / cm, and delivers less than the 0.5 V / cm limit electric field to the total volume in important organs. A treatment plan can be developed. On the other hand, the average electric field strength is the average electric field strength delivered to one organ, and the same electric field is not transmitted to all parts of one organ. Since the electric field strengths are different for each microvolume, the average electric field strength is determined for one organ.

First, at a position spaced a predetermined distance from the tumor

After calculating the value of the electric field in Equation 1, the intensity of the electric field can be calculated from the conditions of Equations 2 to 4.

[Equation 1]

here,

Is the electric field strength at point i,

Is the weight of the j th electrode,

Is the strength of the electric field transmitted to point i due to the j th electrode.

Equation 2 is calculated based on the strength of the prescription electric field as follows.

[Equation 2]

here,

Is the strength of the prescription electric field.

Equation 3 is to calculate the electric field based on the weight of the importance of the long term and the objective function (f) considering the limit electric field strength of the normal organ. The strength of the marginal electric field is a constant that depends on the importance of the organ.

[Equation 3]

here,

Is the weight for each organ,

Is the limit electric field strength value of the Nth normal organ.

Equation 4 is calculated by considering the weight of each organ and the average electric field strength of the N-th normal organ.

[Equation 4]

Is the weight for each organ,

Is the average electric field strength value of the Nth normal organ.

As described above, the objective function for calculating the electric field acting in the normal organ is not limited to the above equation, and may be used in various ways in consideration of the type and location of the tumor.

In this way, the present invention is a voltage applied to the electrode is within 0V ~ 150V, the frequency is formed to a value between 100 ~ 300kHz to calculate the electric field value, is applied to the body in consideration of the location of the tumor and the importance of each organ, etc. The electric field is calculated. In addition, the intensity of the electric field calculated through the above-described method is converted into a voltage applied to the electrode.

The range of the voltage set as described above may belong to the same range as the conventional treatment device, the present invention, in consideration of the position and the relationship between the tumor and normal organs, and differently set the arrangement and position of the electrode, a plurality of electrodes The therapeutic magnetic field and the general magnetic field of different sizes can be applied to prevent normal tissue from being damaged.

It demonstrates with reference to FIG. First, an electric field cancer treatment method using an optimization algorithm according to an embodiment of the present invention is to treat a tumor by transmitting an electric field to a patient's tumor and normal tissue using a pair of electrode pads having a plurality of electrodes.

First, classify the called image image for each organ by calling the image image based on the image image of the patient (S100). By specifying different resolution ranges for each organ, organs can be classified more effectively according to their importance.

Next, the number and positions of the electrodes are arranged on the electrode pad having a predetermined size based on the patient's tumor and the boundary state between the tumor and the normal tissue through the electric field optimizer, and the magnitude of the voltage applied to the plurality of electrodes is calculated. Establish at least one treatment plan (S200). In this case, preferably, three or more treatment plans may be established, and the treatment plans to be established are set to vary in size and number of different electrodes.

The method of arranging the electrodes may be arranged in the form of a square matrix as shown in FIG. 2, but alternatively, asymmetry or spacing may be variously set. However, it is preferable that the pair of electrodes facing each other be formed at the same position with each other. In addition, the voltage and frequency applied are set differently between the tumor and normal tissue, the voltage is within 0V ~ 150V, the frequency can be formed with a value between 100 ~ 300kHz.

Analyze and evaluate the established treatment plan (S300). By analyzing and evaluating a plurality of treatment plans individually, one can extract conditions that yield optimal results.

Finally, the treatment is performed by applying the calculated voltages to the plurality of electrodes under optimal conditions of the analyzed treatment plan (S400).

First, referring to FIG. 4, FIG. 4 shows an electric field when a different voltage value is applied to each electrode by applying an electric field distribution and an electric field optimizer which are obtained when the same voltage value is applied to all electrodes in the conventional manner. It shows the distribution (after).

The two figures below the arrow of FIG. 4 are enlarged simulations of the esophagus. When the red color indicating the high electric field strength is applied to the electric field optimizer and the voltage values of different sizes are applied, the electric field strength decreases. Could.

Table 1 is a quantitative analysis of Figure 4, the V ₃₀ indicator is the relative volume delivered 30% (1.5V / cm × 0.3 = 0.45V / cm) of the electric field strength, V ₆₀ , V ₉₀ represents the relative volume delivered 60% and 90% of the prescription field strength, respectively, and Eave represents the average field strength delivered to the organ. Comparing the before and after application of the field optimizer, the field strength of major organs is reduced.

TABLE 1

Figure 5 shows the electric field distribution (after) when the different voltage values are applied to each electrode by applying the electric field distribution (before) and the optimization algorithm obtained when the same voltage value is applied to all electrodes in the conventional manner.

In the case of elongation, it can be confirmed qualitatively that the red color which shows high electric field strength after application is less than before application of optimization algorithm.

Table 2 shows a quantitative analysis of FIG. 5, and all indicator values after applying the electric field optimizer are reduced. That is, it can be seen that the electric field strength delivered to the normal organ is greatly reduced after applying the electric field optimizer.

TABLE 2

On the other hand, the embodiments of the present invention disclosed in the specification and drawings are merely presented specific examples to easily explain the technical contents and help the understanding of the present invention, and are not intended to limit the scope of the present invention. It will be apparent to those skilled in the art that other modifications based on the technical idea of the present invention can be carried out in addition to the embodiments disclosed herein.

Claims

In the electric field cancer treatment treatment device for treating a tumor by applying an electric field to the tumor and normal tissue of the patient using a pair of electrode pads having a plurality of electrodes,

An image classification unit classifying at least one or more organs in the captured image of each patient for each organ; And

An electric field optimizer for arranging the electrodes on a predetermined size electrode pad by calculating the number and positions of electrodes applied based on the classified tumor and normal tissue, and determining the magnitudes of voltages having different sizes to the electrodes; Electric cancer treatment device using an optimization algorithm comprising.
The method of claim 1,

The electric field optimizer,

The electric field cancer treatment using the optimization algorithm, the voltage magnitude to be applied to the plurality of electrodes is calculated in consideration of at least one or more of the type of tumor, the location of the tumor and the boundary state between the tumor and normal tissue. Device.
The method of claim 2,

The electric field optimizer,

An electric field cancer treatment apparatus comprising applying a prescribed electric field strength to a tumor and calculating a voltage level of an electrode so that the tumor can be delivered to a minimum in a normal organ.
The method of claim 2,

The electric field optimizer,

The electric field cancer treatment apparatus using the optimization algorithm, characterized in that for setting the threshold electric field value according to the importance of the organ, so that the electrode is delivered to below the preset limit electric field value.
The method of claim 3,

The electric field optimizer,

Electric field cancer treatment apparatus using an optimization algorithm characterized in that it comprises an objective function selected by using at least one or more of the electric field strength, normal organ weights and threshold electric field value delivered to the tumor or normal organs.
The method of claim 1,

The pair of electrode pads,

An electric field cancer treatment apparatus using an optimization algorithm, characterized in that formed on one side of the pair ground (G).
In the electric field cancer treatment treatment method of treating a tumor by applying an electric field to the tumor and normal tissue of the patient using a pair of electrode pads having a plurality of electrodes,

Classifying the image by each organ by calling the image based on the image of the patient;

The number and positions of electrodes are arranged on electrode pads having a predetermined size based on the tumor of the patient and the boundary state between the tumor and the normal tissue, and the magnitude of the voltage applied to the plurality of electrodes is calculated by the electric field optimizer. Establishing a treatment plan;

Analyzing and evaluating the established treatment plan; And

And applying an electric field to the plurality of electrodes under optimal conditions of the analyzed treatment plan.
The method of claim 7, wherein

An electric field cancer treatment method of applying an electric field to a tumor through the electric field optimizer and calculating an magnitude of electrode voltage that can be delivered to a normal tissue to a minimum.
The method of claim 7, wherein

Voltage and frequency applied to the electrode, respectively,

An electric field cancer treatment method for applying an electric field, which is within 0 V to 150 V and a value between 100 and 300 kHz.
The method of claim 7, wherein

The magnitude of the voltage applied to the electrode,

An electric field cancer treatment method, characterized in that determined using at least one or more of the size of the prescribed electric field and the weight for each organ and a predetermined limit electric field value applied to the tumor.