CN109394334A - A kind of high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor and system - Google Patents
A kind of high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor and system Download PDFInfo
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- CN109394334A CN109394334A CN201811403226.0A CN201811403226A CN109394334A CN 109394334 A CN109394334 A CN 109394334A CN 201811403226 A CN201811403226 A CN 201811403226A CN 109394334 A CN109394334 A CN 109394334A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00434—Neural system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
- A61B2018/1246—Generators therefor characterised by the output polarity
- A61B2018/126—Generators therefor characterised by the output polarity bipolar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1425—Needle
Abstract
The present invention provides a kind of high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor, including main control unit, steep-sided pulse generating unit, output control and monitoring unit, output electrode needle unit, main control unit are made of main control computer；Steep-sided pulse generating unit includes steep-sided pulse power supply and emergency stop button；Output control and monitoring unit include steep-sided pulse o controller, steep-sided pulse output port and steep-sided pulse output monitoring oscillograph；Output electrode needle unit is steep-sided pulse electrode needle, is connected on steep-sided pulse output port.Additionally provide a kind of high-voltage bipolar steep-sided pulse group system of tumor treatment and method.The output of bipolar positive and negative steep-sided pulse group waveform is realized using present invention treatment tumour, symmetry electroporation can be formed on the cell membrane of tissue, increase the uniformity of irreversibility electroporation, reduce ablation blind area, increase the hole diameter of the two sides electroporation of cell membrane of cell, irreversible electroporation treatment effect is improved, can be widely applied to the oncotherapy of human body and animal.
Description
Technical field:
The invention belongs to oncotherapy technical field, in particular to a kind of high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor and
System.
Background technique:
Irreversible electroporation (IRE) is a tumour ablation technology new in relation to oncotherapy, it passes through release high-tension pulse
It is punched in formation nanoscale on tumour cell permanently to perforate, destroys cell inner equilibrium, make cell rapid apoptosis.Pass through numerous clinics
Studies have shown that the new technology is that a kind of safe and efficient oncotherapy technology has compared with other oncotherapy technologies
Following advantage: (1) ablation time is short: one group for the treatment of time less than one minute, therefore even if there are three or four it is overlapped
Zone of ablation, whole ablation time are not more than 5 minutes；(2) vital tissues such as blood vessel, nerve for the treatment of region are protected
Stay: new tumour ablation technology can protect institutional framework important in zone of ablation, such as arteria hepatica, vena hepatica, portal vein, liver liner
Guan Junneng obtains good protection；(3) not by heat island effects: the technology mainly punctures cell membrane by electric pulse,
Heat will not be generated during this, will not be influenced by other ambient temperatures；(4) treated, and inactivation area boundary understands:
Regardless of tumor locus, size, shape, inactivating region inner cell all can be dead, and the zone boundary after inactivation is fully aware of, can
Reach the thickness of 1-2 cell, can be seen under the microscope and generally；(5) treatment region can restore normal function: induction
There is apoptosis in tumour cell, can promote cell death using being immunized, and human body will be identified as Apoptosis in normal cell
Then death process is eliminated apoptosis tissue by cytophagy, the regeneration and reparation of normal tissue are promoted；(6) may be used
With real time monitoring: clinical advantage further includes that can be monitored in real time not by using navigation (using the medical images such as ultrasound, CT, MRT)
The process of reversible electroporation can determine inactivation degree by computer generated image, observe the residual tumor not being treated,
To carry out irreversible electroporation inactivation again, in addition, real-time imaging monitoring can estimate complication relevant to inactivating.
Currently, the clinical application of irreversible electroporation (IRE) is required using general anesthesia to eliminate in each pulse process
The contraction of muscle of generation, contraction of muscle may influence the position of the syringe needle of implantation, cause therapeutic scheme invalid, or even to surrounding group
It knits and damages.There is the method using two way alternate pulsed discharge in the prior art, as disclosed in patent of invention CN106943190
Mould occurs for a kind of two-way steep-sided pulse system of tumor treatment, including control module, photoelectric isolation module, drive module and dipulse
The control signal of block, control module output passes to drive module after photoelectric isolation module, the output end of drive module with
The input terminal connection of module occurs for dipulse, and it includes two pulse input output points that module, which occurs, for dipulse, in control module
Controlling lower two pulse output points can be realized positive negative pulse stuffing alternately output；The system can pass through two way alternate pulsed discharge
Effect achievees the purpose that weaken contraction of muscle degree to weaken muscle stored charge.
Summary of the invention:
The purpose of the present invention is intended to provide a kind of high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor and system, so that steep-sided pulse
It is more efficient to act on tumor tissues.
To achieve the above object, the present invention takes following technical scheme:
A kind of high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor, including main control unit, steep-sided pulse generating unit, output control
With monitoring unit, output electrode needle unit, in which: the main control unit is mainly made of main control computer；The steep-sided pulse occurs
Unit includes steep-sided pulse power supply and emergency stop button, and main control computer is connected by USB port with steep-sided pulse power supply, emergent stopping
Button is arranged on steep-sided pulse power supply；The output control includes steep-sided pulse o controller, steep-sided pulse output with monitoring unit
Port and steep-sided pulse output monitoring oscillograph, steep-sided pulse o controller one end are connected on steep-sided pulse power supply and main control computer,
Other end connection corresponding with steep-sided pulse output port, the input terminal and steep-sided pulse power supply of steep-sided pulse output monitoring oscillograph export
It is connected, the output end of steep-sided pulse output monitoring oscillograph is connected on main control computer；The output electrode needle unit is rake vein
Electrode needle is rushed, is connected on steep-sided pulse output port.
Further, above-mentioned steep-sided pulse o controller is made of the matrix switch that 12 electromagnetic relays are arranged into 2*6,
For controlling each road on-off, corresponding steep-sided pulse output port is sent into pulse.
Further, above-mentioned steep-sided pulse output port includes 6 delivery outlets, defeated for docking high pressure steep-sided pulse electrode needle
Steep-sided pulse voltage out.
Further, above-mentioned high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor further includes a pulse output control unit,
Pulse signal is separately dispensed on two ports in 6 output ports, a pulse period, only two of them delivery outlet was defeated
High-voltage pulse out will instruct switching output port according to main control computer between the period.
The present invention also provides a kind of high-voltage bipolar steep-sided pulse group system of tumor treatment, mainly include main control module, rake vein
Module, output control and monitoring module, output port module and electrode pin module occur for punching, and main control module is by USB port to steep
Pulse generating module issues instruction, and steep-sided pulse signal passes to output control and monitoring module after module occurs for steep-sided pulse,
Output control is connect with the output end of monitoring module with the input terminal of output electrode pin module, and output control is defeated with monitoring module
Outlet includes that 6 high pressure steep-sided pulse output ports are connected with electrode needle, according to tumor size and shape under the control of main control module
Shape chooses 2-6 root electrode needle, the position treated needed for being implanted to, to realize the output treatment of bipolar positive and negative steep-sided pulse group.
Further, above-mentioned main control module includes surgery planning module, steep-sided pulse unit for electrical property parameters module, control treatment mould
Block and real-time display module, in which: the quantity of electrode needle needed for the surgery planning module is used to be arranged treatment, is set position
Set the sequence and treatment time that every electrode needle steep-sided pulse voltage applies；The steep-sided pulse unit for electrical property parameters module is steep for being arranged
The output pulse group number of pulse, pulse group work repetition rate, pulse number, single pulse voltage, single arteries and veins in pulse group
Rush the parameters such as width；The control treatment module is used for the steep-sided pulse state modulator power supply system according to surgery planning scheme and setting
System in sequence treats required each electrode needle output steep-sided pulse signal；The real-time display module is for receiving monitoring mould
The steep-sided pulse output signal of block acquisition and on the screen showing real-time wave and relevant parameter.
Further, it includes an emergent stopping module that module, which occurs, for above-mentioned steep-sided pulse, in case of emergency from outside
Arrestment is forced to export steep-sided pulse signal.
A method of using above-mentioned high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor, comprising the following steps:
1) arteries and veins in the pulse group number, pulse group work repetition rate, pulse group of main control computer setting steep-sided pulse is first passed through
The parameters such as number, single pulse voltage, single pulse width are rushed, steep-sided pulse power supply are sent instructions to by main control computer, control is steep
The output of pulse；
2) steep-sided pulse exported is output to steep-sided pulse o controller by steep-sided pulse power supply；
3) after steep-sided pulse o controller receives the control signal of main control computer, switch the output port of steep-sided pulse；
4) steep-sided pulse output monitoring oscillograph monitoring output waveform and relevant parameter:
A. it monitors waveform and relevant parameter passback main control computer is displayed on the screen, and judge whether output meets setting ginseng
Number；
B. main control computer sends instructions to the output of steep-sided pulse output controller controls steep-sided pulse according to the surgery planning of setting
To corresponding output port；
5) steep-sided pulse o controller output port is connected to steep-sided pulse electrode needle, steep-sided pulse voltage contacts are controlled needed for
The position for the treatment of；
6) steep-sided pulse electrode needle is implanted into entity software tumor tissues in need for the treatment of.
Since the present invention is the steep-sided pulse of the exponential damping waveform generated by steep-sided pulse generating system, on pulse is quick
Rising along part includes a large amount of high fdrequency components, and the films such as internal nucleus, mitochondria can be acted on through the cell membrane of tumour cell
Inner cell organ.Include low frequency component in the failing edge of slow-decay, mainly acts on the cell membrane of tumour cell.Therefore, entirely
Steep-sided pulse contains from the pole broad spectrum of direct current, low frequency, high frequency to very high frequency(VHF) and acts on tumour cell.Moreover, according to Wang
Harmonious and Xie Tingdong " the cell electroporation electro' asion electro photoluminescence-principle art published in Tianjin science tech publishing house in 2000
And application ", research shows that: if after biomembrane is perforated under the crest voltage effect of electric pulse, it can be with lower electricity
Pressure maintains membrane micropore open a period of time, is conducive to the efficiency for improving biomembrane perforation, then exponential decay pulse compares same dose
Square-wave pulse it is more effective.Therefore, tumour cell is acted on using steep-sided pulse, comprehensive destruction can be generated to it, reduced
Act on the energy of cell.Meanwhile the present invention uses steep-sided pulse group, the pulsewidth width of an original pulse is divided into multiple narrow
Width pulse forms steep-sided pulse group and completes identical pulsewidth, reduces each pulse pair cytosis energy, reduces the thorn to nerve
Swash effect, reduces the spasm of musculature.
Simultaneously as what the electroporation on cell membrane was unevenly distributed, the diameter of hole is at nm grades.Ephrem
Tekle's etc. research shows that: towards the two sides of cathode and anode electroporation, and the cell membrane towards cathode all occur for cell membrane
On hole diameter it is larger, the hole diameter on the cell membrane towards anode is smaller.The present invention is using bipolar positive and negative steep-sided pulse electricity
Porate cells increase the hole diameter of the two sides electroporation of cell membrane of cell, improve irreversible electroporation treatment effect.And
The uniformity of irreversibility point perforation can be increased, the stimulation to nerve is reduced, reduce the spasm of musculature.Therefore,
Therapeutic effect can be greatly improved using bipolar positive and negative steep-sided pulse group, and can be reduced the stimulation to nerve, reduce muscle groups
The spasm knitted.
Compared with prior art, the beneficial effects of the present invention are:
(1) the device of the invention structure is simple, easy to use and flexible, realizes the defeated of bipolar positive and negative steep-sided pulse group waveform
Out, according to the setting of therapeutic scheme program, it can precisely adjust and be arranged high voltage power supply parameter.
(2) clinically symmetry can not only be formed on the cell membrane of tissue in treatment neoplastic process using the present invention
Electroporation increases the uniformity of irreversibility electroporation, reduces ablation blind area, makes the hole of the two sides electroporation of cell membrane of cell
Diameter increases, and improves irreversible electroporation treatment effect.And it is more efficient so that nanosecond steep-sided pulse group is acted on tumor tissues,
The stimulation to nerve is significantly reduced, reduces the musculature spasm of human body, or do not cause the contraction of muscle, reduces treatment
Anesthesia requirement in the process.To generate comprehensive destruction to entire tumour cell, irreversible electrical breakdown is brought it about
And dead, the final therapeutic effect and user experience for improving tumour.
(3) present invention can be widely applied to the oncotherapy of human body and animal.
Detailed description of the invention:
Fig. 1 is the schematic diagram of high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor of the present invention；
Fig. 2 is the structural block diagram of high-voltage bipolar steep-sided pulse group system of tumor treatment of the present invention；
Fig. 3 is the waveform diagram of bipolar positive or negative high voltage steep-sided pulse group in the specific embodiment of the invention.
Specific embodiment:
Technical solution of the present invention is described in detail with specific embodiment with reference to the accompanying drawing.
As shown in Figure 1, a kind of high-voltage bipolar steep-sided pulse waveform therapeutic apparatus for treating tumor, including main control unit, steep-sided pulse occur
Unit, output control and monitoring unit, output electrode needle unit, in which: the main control unit is mainly made of main control computer；Institute
Stating steep-sided pulse generating unit includes steep-sided pulse power supply and emergency stop button, and main control computer passes through USB port and steep-sided pulse power supply
It is connected, emergency stop button is arranged on steep-sided pulse power supply；The output control includes that steep-sided pulse output controls with monitoring unit
Device, steep-sided pulse output port and steep-sided pulse output monitoring oscillograph, steep-sided pulse o controller one end are connected to steep-sided pulse power supply
On main control computer, other end connection corresponding with steep-sided pulse output port, the input terminal of steep-sided pulse output monitoring oscillograph with
The output of steep-sided pulse power supply is connected, and the output end of steep-sided pulse output monitoring oscillograph is connected on main control computer；The output electricity
Pole needle unit is steep-sided pulse electrode needle, is connected on steep-sided pulse output port；The steep-sided pulse o controller is by 12 electricity
The matrix switch that magnetic relay is arranged into 2*6 is constituted, and for controlling each road on-off, corresponding steep-sided pulse output end is sent into pulse
Mouthful；The steep-sided pulse output port includes 6 delivery outlets, for docking high pressure steep-sided pulse electrode needle, exports steep-sided pulse voltage.
Above-mentioned high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor further includes a pulse output control unit, by pulse signal
It being separately dispensed on two ports in 6 output ports, a pulse period, only two of them delivery outlet exported high-voltage pulse,
Switching output port will be instructed between period according to main control computer.
As shown in Fig. 2, a kind of high-voltage bipolar steep-sided pulse waveform system of tumor treatment, mainly includes main control module, rake vein
Module, output control and monitoring module, output port module and electrode pin module occur for punching, and main control module is by USB port to steep
Pulse generating module issues instruction, and steep-sided pulse signal passes to output control and monitoring module after module occurs for steep-sided pulse,
Output control is connect with the output end of monitoring module with the input terminal of output electrode pin module, and output control is defeated with monitoring module
Outlet includes that 6 high pressure steep-sided pulse output ports are connected with electrode needle, according to tumor size and shape under the control of main control module
Shape chooses 2-6 root electrode needle, the position treated needed for being implanted to, to realize the output treatment of bipolar positive and negative steep-sided pulse group；Institute
Main control module is stated to include surgery planning module, steep-sided pulse unit for electrical property parameters module, control treatment module and real-time display module,
In: the every quantity of electrode needle needed for the surgery planning module is used to be arranged treatment, position, setting electrode needle steep-sided pulse electricity
Press the sequence applied and treatment time；The steep-sided pulse unit for electrical property parameters module is used to be arranged the output pulse group of steep-sided pulse
It counts, the parameters such as pulse number, single pulse voltage, single pulse width in pulse group work repetition rate, pulse group；The control
System treatment module is used for according to surgery planning scheme and the steep-sided pulse state modulator power-supply system of setting in sequence to required each
Electrode needle output steep-sided pulse signal is treated；The real-time display module is used to receive the steep-sided pulse output of monitoring module acquisition
Signal and on the screen showing real-time wave and relevant parameter；It includes an emergent stopping module that module, which occurs, for the steep-sided pulse, is used
Steep-sided pulse signal is exported from external forced arrestment in case of emergency.
In practical operation, software tumor tissues are controlled using high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor of the present invention
It treats, comprising the following steps:
1) arteries and veins in the pulse group number, pulse group work repetition rate, pulse group of steep-sided pulse is first set in main control computer
The high voltage power supplies parameters such as number, single pulse voltage, single pulse width are rushed, steep-sided pulse electricity is sent instructions to by main control computer
Source controls the output of steep-sided pulse；It is provided that
(1) pulse voltage is continuously adjustable, is continuously adjusted from 0 to positive and negative 7500V, and voltage accuracy is ± 5%；
(2) pulse group work repetition rate is continuously adjustable, is continuously adjusted from 0.1Hz to 10Hz；
(3) pulse number is continuously adjustable in pulse group, the pulse from 1 to 100；
(4) single pulse width is continuously adjustable in every group, is continuously adjusted from 10 μ s to 100 μ s；
(5) maximum surge current 50A is exported；
(6) exportable maximum single pulse energy 15J；
(7) 1 to 1000 pulse group numbers can continuously be exported.
Specific high voltage power supply parameter such as the following table 1:
| High voltage power supply parameter | Setting value |
| The amplitude of steep-sided pulse | 600~3000V/cm |
| Single pulse width | 10 μ of μ s~100 s |
| Pulse number in pulse group | 1~100 |
| Pulse group number | 1~1000 |
| Pulse group repetition rate | 0.1~10Hz |
| Single pulse ceiling capacity | 15J |
| Pulse amplitude precision | ± 5% |
| Pulse width precision | ± 2 μ s or 2% (taking the larger value) |
| Maximum surge current | 50A |
2) steep-sided pulse exported is output to steep-sided pulse o controller by steep-sided pulse power supply；
3) after steep-sided pulse o controller receives the control signal of main control computer, switch the output port of steep-sided pulse；
4) steep-sided pulse output monitoring oscillograph monitoring output waveform and relevant parameter:
A. it monitors waveform and relevant parameter passback main control computer is displayed on the screen, and judge whether output meets setting ginseng
Number；
B. main control computer sends instructions to the output of steep-sided pulse output controller controls steep-sided pulse according to the surgery planning of setting
To corresponding output port；
5) steep-sided pulse output port is connected to steep-sided pulse electrode needle, the portion that steep-sided pulse electrode needle is treated needed for being implanted to
Position；
6) according to the therapeutic scheme of setting, steep-sided pulse electrode needle is implanted into entity software tumor tissues to be treated and is controlled
It treats.
As shown in figure 3, using system above by the method for above-mentioned treatment tumor tissues, in main control computer in detailed process
The real-time waveform and relevant parameter shown on screen are as follows: bipolar positive or negative high voltage steep-sided pulse group.
Claims (8)
1. a kind of high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor, it is characterised in that: including main control unit, steep-sided pulse occurs single
Member, output control and monitoring unit, output electrode needle unit, in which: the main control unit is mainly made of main control computer；It is described
Steep-sided pulse generating unit includes steep-sided pulse power supply and emergency stop button, and main control computer passes through USB port and steep-sided pulse power supply phase
Even, emergency stop button is arranged on steep-sided pulse power supply；Output control and monitoring unit include steep-sided pulse o controller,
Steep-sided pulse output port and steep-sided pulse output monitoring oscillograph, steep-sided pulse o controller one end are connected to steep-sided pulse power supply and master
It controls on computer, other end connection corresponding with steep-sided pulse output port, the input terminal and rake vein of steep-sided pulse output monitoring oscillograph
It rushes power supply output to be connected, the output end of steep-sided pulse output monitoring oscillograph is connected on main control computer；The output electrode needle
Unit is steep-sided pulse electrode needle, is connected on steep-sided pulse output port.
2. high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor according to claim 1, it is characterised in that: the steep-sided pulse is defeated
Controller is made of the matrix switch that 12 electromagnetic relays are arranged into 2*6 out, and for controlling each road on-off, phase is sent into pulse
The steep-sided pulse output port answered.
3. high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor according to claim 1, it is characterised in that: the steep-sided pulse is defeated
Exit port includes 6 delivery outlets, for docking high pressure steep-sided pulse electrode needle, exports steep-sided pulse voltage.
4. high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor according to claim 1, it is characterised in that: the high-voltage bipolar
Steep-sided pulse group therapeutic apparatus for treating tumor further includes a pulse output control unit, and pulse signal is separately dispensed into 6 output ends
On two ports in mouthful, a pulse period, only two of them delivery outlet exported high-voltage pulse, will be according to master control between the period
Computer instruction switches output port.
5. a kind of high-voltage bipolar steep-sided pulse group system of tumor treatment, it is characterised in that: mould occurs including main control module, steep-sided pulse
Block, output control and monitoring module, output port module and electrode pin module, main control module are occurred by USB port to steep-sided pulse
Module issues instruction, and steep-sided pulse signal passes to output control and monitoring module, output control after module occurs for steep-sided pulse
It is connect with the output end of monitoring module with the input terminal of output electrode pin module, output control and the output end of monitoring module include
6 high pressure steep-sided pulse output ports are connected with electrode needle, choose 2-6 according to tumor size and shape under the control of main control module
Root electrode needle, the position treated needed for being implanted to, to realize the output treatment of bipolar positive and negative steep-sided pulse group.
6. high-voltage bipolar steep-sided pulse group system of tumor treatment according to claim 5, it is characterised in that: the main control module
Including surgery planning module, steep-sided pulse unit for electrical property parameters module, control treatment module and real-time display module, in which: the hand
The every quantity of electrode needle needed for art planning module is used to be arranged treatment, position, setting electrode needle steep-sided pulse voltage apply
Sequence and treatment time；The steep-sided pulse unit for electrical property parameters module is used to be arranged output pulse group number, the pulse group of steep-sided pulse
The parameters such as pulse number, single pulse voltage, single pulse width in work repetition rate, pulse group；Mould is treated in the control
Block is used for defeated to required each electrode needle in sequence according to surgery planning scheme and the steep-sided pulse state modulator power-supply system of setting
Steep-sided pulse signal is treated out；The real-time display module be used for receive monitoring module acquisition steep-sided pulse output signal and
Showing real-time wave and relevant parameter on screen.
7. high-voltage bipolar steep-sided pulse group system of tumor treatment according to claim 5, it is characterised in that: the steep-sided pulse hair
Raw module includes an emergent stopping module, in case of emergency exporting steep-sided pulse signal from external forced arrestment.
8. the side of high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor of the application as described in any claim in Claims 1-4
Method, it is characterised in that: the following steps are included:
1) pulse in the pulse group number, pulse group work repetition rate, pulse group of main control computer setting steep-sided pulse is first passed through
The parameters such as number, single pulse voltage, single pulse width send instructions to steep-sided pulse power supply by main control computer, control steep-sided pulse
Output；
2) steep-sided pulse exported is output to steep-sided pulse o controller by steep-sided pulse power supply；
3) after steep-sided pulse o controller receives the control signal of main control computer, switch the output port of steep-sided pulse；
4) steep-sided pulse output monitoring oscillograph monitoring output waveform and relevant parameter:
A. it monitors waveform and relevant parameter passback main control computer is displayed on the screen, and judge whether output meets setting parameter；
B. main control computer sends instructions to steep-sided pulse output controller controls steep-sided pulse and is output to phase according to the surgery planning of setting
The output port answered；
5) steep-sided pulse o controller output port is connected to steep-sided pulse electrode needle, steep-sided pulse voltage contacts to required treatment
Position；
6) steep-sided pulse electrode needle is implanted into entity software tumor tissues in need for the treatment of.
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| CN113018682A (en) * | 2021-02-25 | 2021-06-25 | 杭州维那泰克医疗科技有限责任公司 | Cell division suppressing device, method, device, system and storage medium for controlling the same |
| CN113440247A (en) * | 2020-08-28 | 2021-09-28 | 苏州博思得电气有限公司 | High-frequency irreversible electroporation tumor treatment system |
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| CN114886545B (en) * | 2022-05-07 | 2023-11-28 | 宇寿医疗科技(无锡)有限公司 | Synchronous bipolar short pulse tumor ablation method and device |
| CN114886546A (en) * | 2022-05-09 | 2022-08-12 | 宇寿医疗科技(无锡)有限公司 | Synchronous bipolar short-pulse tumor ablation method and system |
| CN114886546B (en) * | 2022-05-09 | 2023-11-28 | 宇寿医疗科技(无锡)有限公司 | Synchronous bipolar short pulse tumor ablation method and system |
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| WO2024054842A1 (en) * | 2022-09-06 | 2024-03-14 | Maxcyte, Inc. | Apparatus and methods for electroporation |
| CN116077178A (en) * | 2023-04-04 | 2023-05-09 | 浙江伽奈维医疗科技有限公司 | Needle distribution simulating method and system for steep pulse tumor therapeutic apparatus and therapeutic apparatus |
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