CN113018682A - Cell division suppressing device, method, device, system and storage medium for controlling the same - Google Patents
Cell division suppressing device, method, device, system and storage medium for controlling the same Download PDFInfo
- Publication number
- CN113018682A CN113018682A CN202110214201.1A CN202110214201A CN113018682A CN 113018682 A CN113018682 A CN 113018682A CN 202110214201 A CN202110214201 A CN 202110214201A CN 113018682 A CN113018682 A CN 113018682A
- Authority
- CN
- China
- Prior art keywords
- pulse
- electrode patch
- output
- sequence
- pulse sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000032823 cell division Effects 0.000 title claims abstract description 92
- 238000000034 method Methods 0.000 title claims abstract description 40
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 claims abstract description 168
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 61
- 238000004891 communication Methods 0.000 claims abstract description 5
- 230000005684 electric field Effects 0.000 claims description 58
- 238000004590 computer program Methods 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 abstract description 126
- 210000003463 organelle Anatomy 0.000 abstract description 59
- 230000000694 effects Effects 0.000 abstract description 43
- 210000004881 tumor cell Anatomy 0.000 abstract description 17
- 230000001976 improved effect Effects 0.000 abstract description 11
- 230000005764 inhibitory process Effects 0.000 abstract description 8
- 230000002829 reductive effect Effects 0.000 abstract description 7
- 230000002147 killing effect Effects 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 description 12
- 230000009286 beneficial effect Effects 0.000 description 10
- 230000015654 memory Effects 0.000 description 9
- 210000000170 cell membrane Anatomy 0.000 description 8
- 230000001965 increasing effect Effects 0.000 description 8
- 230000006907 apoptotic process Effects 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000005034 decoration Methods 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000012260 Accidental injury Diseases 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 239000012829 chemotherapy agent Substances 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011982 device technology Methods 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 230000002900 effect on cell Effects 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000002977 intracellular fluid Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000004222 uncontrolled growth Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The embodiment of the application provides a cell division inhibition device, a control method, a device, a system and a storage medium thereof. The cell division suppressing device includes: the electrode patch is used for being attached to the surface of skin; the pulse generator is electrically connected with the electrode patch; and the controller is in communication connection with the pulse generator and is used for controlling the pulse generator to output an electric pulse sequence for inhibiting at least part of target cells from dividing or killing at least part of the target cells to the electrode patch. The embodiment of the application realizes that organelles in dividing cells are pulled to the equatorial plate to induce the cells to be disintegrated or broken, so that the effect of inhibiting the cells from being divided or destroying the cells is achieved, the electric pulse sequence hardly influences the cells which are not divided, the distinguishing capability of tumor cells and healthy cells is further improved, the treatment effect can be improved, and the side effect can be greatly reduced.
Description
Technical Field
The present application relates to the field of medical device technology, and in particular, to a cell division inhibiting device, a control method, a device, a system, and a storage medium thereof.
Background
Tumors, especially malignant tumors, are the result of uncontrolled growth of cells relative to normal tissues. The rapid growth of tumors is often the result of relatively frequent cell division or replication of tumor cells relative to healthy cells. Such rapid growth allows the tumor to occupy a growing volume and damage or destroy its adjacent tissues.
In current tumor treatment procedures, radiation therapy and/or chemotherapy is typically employed to selectively deplete or destroy tumor cells. However, the ability of the radiation or chemotherapy agent to distinguish tumor cells from healthy cells is insufficient, so that the existing tumor therapy inevitably causes great accidental injury to the healthy cells while losing or destroying the tumor cells, which not only limits the treatment effect, but also easily causes great side effects to patients.
Disclosure of Invention
The application aims at the defects of the prior art and provides a cell division inhibiting device, a control method, a device, a system and a storage medium thereof, which are used for solving the technical problem that the capacity of distinguishing tumor cells from healthy cells by radiation or chemotherapeutic agents is insufficient in the prior art.
In a first aspect, embodiments of the present application provide a cell-division inhibiting device, comprising:
the electrode patch is used for being attached to the surface of skin;
the pulse generator is electrically connected with the electrode patch;
and the controller is in communication connection with the pulse generator and is used for controlling the pulse generator to output an electric pulse sequence for inhibiting at least part of target cells from dividing or killing at least part of the target cells to the electrode patch.
In a second aspect, the present embodiments provide a method for controlling a cell division suppressing device according to the first aspect, including:
controlling a pulse generator in the cell-division inhibiting device to output a sequence of electrical pulses to the electrode patch to inhibit division of or kill at least a portion of the target cells.
In a third aspect, embodiments of the present application provide a control device for a cell division inhibiting device, including:
and the electric pulse control module is used for controlling the pulse generator in the cell division inhibiting device to output an electric pulse sequence to the electrode patch so as to inhibit at least part of target cells from dividing or kill at least part of target cells.
In a fourth aspect, embodiments of the present application provide a computer-readable storage medium, which stores a computer program, and the computer program, when executed by a controller, implements the method for controlling the cell-division inhibiting device according to the second aspect.
In a fifth aspect, embodiments of the present application provide a cell division inhibiting system, comprising: a cell-division suppressing device as provided in the first aspect, and a host computer;
the upper computer is in communication connection with a controller in the cell division inhibiting device.
The cell division inhibition device and the cell division inhibition system provided by the embodiment of the application have the beneficial technical effects that: the controller can control the pulse generator to output an electric pulse sequence to the electrode patch, so that the electrode patch can apply the electric pulse sequence to tissues of a focal zone, the electric pulse sequence can inhibit organelles in cells which are dividing from moving towards two poles, even can pull the organelles to an equatorial plate, induce the cells to be collapsed or broken, and achieve the effect of inhibiting the cells from being divided or destroying the cells, and the electric pulse sequence hardly causes influence on the cells which are not divided, so that the distinguishing capability of the tumor cells and the healthy cells is improved, the treatment effect can be improved, and the side effect can be greatly reduced.
The control method, the control device and the computer-readable storage medium of the cell division inhibiting device provided by the embodiment of the application bring beneficial technical effects that: the electric pulse sequence can be controlled to output the electric pulse sequence to the electrode patch, so that the electrode patch can apply the electric pulse sequence to tissues of a focus area, the electric pulse sequence can inhibit organelles in cells which are dividing from moving towards two poles, even can pull the organelles to an equatorial plate, induce the cells to be collapsed or broken, and achieve the effect of inhibiting the cells from dividing or destroying the cells, and the electric pulse sequence hardly causes influence on the cells which are not divided, so that the capacity of distinguishing the tumor cells from the healthy cells is improved, the treatment effect can be improved, and the side effect can be greatly reduced.
Additional aspects and advantages of the present application will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the present application.
Drawings
The foregoing and/or additional aspects and advantages of the present application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
FIG. 1 is a schematic diagram of a cell-division suppressing apparatus according to an embodiment of the present disclosure;
FIG. 2 is a schematic block diagram of a cell division inhibition system according to an embodiment of the present disclosure;
fig. 3 is a schematic flowchart of a first embodiment of controlling a pulse generator to alternately output a first pulse sequence and a second pulse sequence to an electrode patch in a control method based on a cell division inhibition device according to an embodiment of the present disclosure;
fig. 4 is a schematic flowchart of a second embodiment of controlling a pulse generator to alternately output a first pulse sequence and a second pulse sequence to an electrode patch in a control method based on a cell division inhibition device according to an embodiment of the present disclosure;
fig. 5 is a schematic flow chart of a third embodiment of controlling a pulse generator to alternately output a first pulse sequence and a second pulse sequence to an electrode patch in a control method based on a cell division suppression device according to an embodiment of the present disclosure.
In the figure:
100-cell division inhibition system; 110-a cell division inhibiting device; 111-electrode patch; 112-a pulse generator; 113-a controller; 120-an upper computer.
Detailed Description
Reference will now be made in detail to the present application, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar parts or parts having the same or similar functions throughout. In addition, if a detailed description of the known art is not necessary for illustrating the features of the present application, it is omitted. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present application and are not to be construed as limiting the present application.
It will be understood by those within the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. It will be understood that when an element is referred to as being "connected" or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may also be present. Further, "connected" or "coupled" as used herein may include wirelessly connected or wirelessly coupled. As used herein, the term "and/or" includes all or any element and all combinations of one or more of the associated listed items.
The inventors of the present application have conducted studies to find that mitosis in most cells generally includes: the organelles in the cells are multiplied, the doubled organelles move towards the two poles of the cells respectively, a cell plate is formed at the equatorial plate of the cells, and finally the cell division is completed.
The cells are typically in a conductive environment consisting primarily of electrolyzed intercellular fluid, and other cells consisting primarily of electrolyzed intracellular fluid, and the organelles are typically polarizable; when a polarizable substance is placed in a non-uniform converging or diverging electric field, the force of the electric field pulls the polarizable substance toward a higher density of electric field lines.
When an electric potential is applied to a cell to induce an electric field in the cell, organelles in the cell can move according to the dielectric property of the organelles under the action of the electric field. For a cell which is dividing, electric field lines induced in the cell can be gathered at the equatorial plate, and the organelle can be subjected to an electric field force pointing to the equatorial plate, namely the electric field force can limit the organelle to move towards two poles, so that certain inhibiting effect on cell division can be achieved; furthermore, as the degree of cell division increases (i.e., the equatorial plate narrows), the electric field lines at the equatorial plate become denser, and the increased electric field force pulls the organelles toward the equatorial plate, thus inhibiting the formation of the cell plate, and further inhibiting cell division, even inducing cell rupture and apoptosis.
Because the division frequency of the tumor cells is far greater than that of the healthy cells, the tumor cells can be regarded as the divided cells, and the healthy cells can be regarded as the non-divided cells, so that the tumor cells can be damaged by applying an electric field without damaging the healthy cells, namely, the tumor cells and the healthy cells can be distinguished by applying the electric field to treat the tumor, the treatment effect can be improved, and the side effect can be greatly reduced.
The present application provides a cell division suppressing device, a method, a device, a system, and a storage medium for controlling the same, which are intended to solve the above-mentioned technical problems of the prior art.
The following describes the technical solutions of the present application and how to solve the above technical problems with specific embodiments.
The embodiment of the present application provides a cell-division suppressing device 110, and the schematic structural diagram of the cell-division suppressing device 110 is shown in fig. 1, including but not limited to: an electrode patch 111, a pulse generator 112, and a controller 113.
The electrode patch 111 is for attachment to the skin surface.
The pulse generator 112 is electrically connected to the electrode patch 111.
The controller 113 is communicatively connected to the pulse generator 112, and the controller 113 is configured to control the pulse generator 112 to output a sequence of electrical pulses to the electrode patch 111 that inhibits division of or kills at least a portion of the target cells.
In this embodiment, the controller 113 may control the pulse generator 112 to output a sequence of electrical pulses to the electrode patch 111, so that the electrode patch 111 can apply the sequence of electrical pulses to the tissue of the focal zone, and the sequence of electrical pulses may apply a potential to the target cells to induce an electric field in the target cells.
For the dividing cells, on one hand, electric field lines induced in the cells are gathered at the equatorial plate, and the organelles are subjected to electric field force directed to the equatorial plate, namely, the electric field force can limit the organelles to move towards two poles, so that certain inhibiting effect on cell division can be achieved.
On the other hand, as the degree of cell division increases (i.e., the equatorial plate narrows), the electric field lines at the equatorial plate become denser, and the increased electric field force can pull the organelles toward the equatorial plate, thus hindering the formation of the cell plate, and further inhibiting cell division, even inducing cell rupture or apoptosis.
On the other hand, the cellular organelles are gathered at the equatorial plate, which causes an increase in the pressure near the equatorial plate, which may rupture the cell membrane, especially in the state of narrowing of the equatorial plate. And the electric pulse sequence can make the organelle receive pulse electric field force, i.e. make the organelle have a certain hammer effect, thus can improve the possibility of rupture of the cell membrane. In addition, the pulsed electric field force applied to the organelles also affects the structures of the organelles, and can induce the disintegration or the rupture of the organelles and further induce the cell rupture or the apoptosis.
Therefore, the cell division inhibiting device 110 provided in the embodiment of the present application controls the pulse generator 112 to output the electric pulse sequence to the electrode patch 111 through the controller 113, so that the electrode patch 111 can apply the electric pulse sequence to the tissue in the focal region, can inhibit the organelles in the dividing cells from moving to two poles, even pull the organelles to an equatorial plate, induce the cells to collapse or break, and achieve the effect of inhibiting the cells from dividing or destroying the cells, and the electric pulse sequence hardly affects the cells which are not divided, thereby improving the ability of distinguishing the tumor cells from the healthy cells, not only improving the treatment effect, but also greatly reducing the side effects.
In some possible embodiments, the cell-division suppressing device 110 may further include: a memory. The controller 113 and the memory are electrically connected, such as by a bus. Alternatively, the controller 113 may be a CPU (Central Processing Unit), a general-purpose Processor, a DSP (Digital Signal Processor), an ASIC (Application Specific Integrated Circuit), an FPGA (Field-Programmable Gate Array) or other Programmable logic device, a transistor logic device, a hardware component, or any combination thereof. Which may implement or perform the various illustrative logical blocks, modules, and circuits described in connection with the disclosure. The controller 113 may also be a combination of implementing computing functions, e.g., comprising one or more microprocessors, DSPs and microprocessors, and the like.
Alternatively, the bus may include a path that carries information between the aforementioned components. The bus may be a PCI (Peripheral Component Interconnect) bus, an EISA (Extended Industry Standard Architecture) bus, or the like. The bus may be divided into an address bus, a data bus, a control bus, etc.
Alternatively, the Memory may be, but is not limited to, a ROM (Read-Only Memory) or other type of static storage device that can store static information and instructions, a RAM (random access Memory) or other type of dynamic storage device that can store information and instructions, an EEPROM (Electrically Erasable Programmable Read Only Memory), a CD-ROM (Compact Disc Read-Only Memory) or other optical Disc storage, optical Disc storage (including Compact Disc, laser Disc, optical Disc, digital versatile Disc, blu-ray Disc, etc.), a magnetic disk storage medium or other magnetic storage device, or any other medium that can be used to carry or store desired program code in the form of instructions or data structures and that can be accessed by a computer.
In some possible embodiments, the cell-division suppressing device 110 may further include a monitoring unit. The monitoring unit may be configured to monitor current and/or voltage parameters of the electrode patch 111, and the controller 113 determines the operating state of the electrode patch 111 through the current and/or voltage parameters of the electrode patch 111 obtained by the monitoring unit. For example, if the current and/or voltage parameters of the electrode patch 111 obtained by the monitoring unit are consistent with the current and/or voltage of the electrode patch 111 when the electrode patch is empty (not connected to a load), it is determined that the electrode patch 111 has finished outputting the electric pulse sequence.
In some possible embodiments, the cell-division inhibiting device 110 may also include a transceiver. The transceiver may be used for reception and transmission of signals. The transceiver may allow the controller 113 of the cell-division inhibiting device 110 to communicate wirelessly or by wire with other devices for exchanging data, for example, when the controller 113 receives an ablation-stopping command or a needle-withdrawing command from a user via the transceiver, the controller 113 is triggered to control the pulse generator 112 to start the output electric pulse sequence or control the pulse generator 112 to stop the output electric pulse sequence. It should be noted that the number of the transceivers in practical application is not limited to one.
In some possible embodiments, the cell-division suppressing apparatus 110 may further include an input unit. The input unit may be used to receive input numeric, character, image and/or sound information or to generate key signal inputs related to user settings and function control of the controller 113. The input unit may include, but is not limited to, one or more of a touch screen, a physical keyboard, function keys (such as volume control keys, switch keys, etc.), a trackball, a mouse, a joystick, a camera, a microphone, and the like.
In some possible embodiments, the cell-division suppressing device 110 may further include an output unit. The output unit may be used to output or present information processed by the controller 113. The output unit may include, but is not limited to, one or more of a display device, a speaker, a vibration device, and the like.
It will be appreciated by those skilled in the art that the controller 113 of the cell-division suppressing apparatus 110 provided in the embodiments of the present application may be specially designed and manufactured for the required purposes, or may also include known devices in general-purpose computers. These devices have stored therein computer programs that are selectively activated or reconfigured. Such a computer program may be stored in a device (e.g., computer) readable medium or in any type of medium suitable for storing electronic instructions and respectively coupled to a bus.
Based on the same inventive concept, the present application provides a method for controlling a cell division inhibiting device based on the foregoing embodiments, which includes but is not limited to:
controlling a pulse generator in the cell-division inhibiting device to output a sequence of electrical pulses to the electrode patch to inhibit division of or kill at least a portion of the target cells.
Optionally, the controller 113 controls the pulse generator 112 in the cell-division suppressing device 110 to output a sequence of electric pulses to the electrode patch 111 to suppress division of or kill at least a portion of the target cells.
In this embodiment, the controller 113 of the cell-division suppressing apparatus 110 controls the pulse generator 112 to output an electric pulse sequence to the electrode patch 111, so that the electrode patch 111 can apply the electric pulse sequence to the tissue of the focal region, and the electric pulse sequence can apply a potential to the target cell to induce an electric field in the target cell.
For the dividing cells, on one hand, electric field lines induced in the cells are gathered at the equatorial plate, and the organelles are subjected to electric field force directed to the equatorial plate, namely, the electric field force can limit the organelles to move towards two poles, so that certain inhibiting effect on cell division can be achieved.
On the other hand, as the degree of cell division increases (i.e., the equatorial plate narrows), the electric field lines at the equatorial plate become denser, and the increased electric field force can pull the organelles toward the equatorial plate, thus hindering the formation of the cell plate, and further inhibiting cell division, even inducing cell rupture or apoptosis.
On the other hand, the cellular organelles are gathered at the equatorial plate, which causes an increase in the pressure near the equatorial plate, which may rupture the cell membrane, especially in the state of narrowing of the equatorial plate. And the electric pulse sequence can make the organelle receive pulse electric field force, i.e. make the organelle have a certain hammer effect, thus can improve the possibility of rupture of the cell membrane. In addition, the pulsed electric field force applied to the organelles also affects the structures of the organelles, and can induce the disintegration or the rupture of the organelles and further induce the cell rupture or the apoptosis.
Therefore, in the control method of the cell division inhibiting device provided by the embodiment of the present application based on the foregoing embodiment, the controller 113 controls the pulse generator 112 to output the electric pulse sequence to the electrode patch 111, so that the electrode patch 111 can apply the electric pulse sequence to the tissue of the focal region, and can inhibit the movement of the organelles in the dividing cells to two poles, even pull the organelles to the equatorial plate, induce the cell to collapse or break, so as to achieve the effect of inhibiting the cell division or destroying the cell, and the electric pulse sequence hardly affects the non-dividing cell, thereby improving the ability of distinguishing the tumor cell from the healthy cell, not only improving the treatment effect, but also greatly reducing the side effects.
In some possible embodiments, controlling the pulse generator in the cell-division inhibiting device to output a sequence of electrical pulses to the electrode patch includes, but is not limited to: controlling a pulse generator to alternately output a first pulse sequence and a second pulse sequence to the electrode patch; the frequency of the first pulse train is different from the frequency of the second pulse train.
Alternatively, the controller 113 controls the pulse generator 112 to alternately output the first pulse train and the second pulse train to the electrode patch 111; the frequency of the first pulse train is different from the frequency of the second pulse train.
In this embodiment, the controller 113 controls the pulse generator 112 to alternately output two pulse sequences with different frequencies to the electrode patch 111, which is favorable for meeting the requirements of target cells with different sizes on the electric field intensity and improving the treatment effect; on the other hand, the fatigue of the cells to the electric pulse sequence with single frequency can be reduced, which is beneficial to continuously realizing effective treatment.
In some possible embodiments, at least one of the first pulse train and the second pulse train comprises a square wave pulse train.
Optionally, the first pulse train is a square wave pulse train.
Optionally, the second pulse sequence is a square wave pulse sequence.
Optionally, the first pulse train and the first pulse train are both square wave pulse trains.
In this embodiment, each electric pulse in the square wave pulse sequence applies a relatively stable electric potential to the target cell, which is beneficial to subjecting the organelle to a relatively constant pulsed electric field force, drawing the organelle toward the equatorial plate, or hammering the cell membrane by the organelle.
The inventors of the present application considered that the first pulse train and the second pulse train output from the pulse generator to the electrode patch may be alternately output. For this reason, the present application provides the following three possible implementations for the alternating output form of the first pulse sequence and the second pulse sequence:
in some possible embodiments, as shown in fig. 3, the pulse generator is controlled to alternately output the first pulse sequence and the second pulse sequence to the electrode patch, including but not limited to steps S101-S102:
s101: after determining that at least one first electrical pulse in the first pulse sequence is output by the electrode patch, controlling the electrode patch to output at least one second electrical pulse in the second pulse sequence.
Alternatively, after the controller 113 determines that at least one first electrical pulse in the first pulse sequence is output through the electrode patch 111, the controller 113 controls the pulse generator 112 to output at least one second electrical pulse in the second pulse sequence to the electrode patch 111.
S102: after determining that at least a portion of the first electrical pulses in the first pulse train are output by the electrode patch, the electrode patch is controlled to output at least another second electrical pulse in the second pulse train.
Alternatively, after the controller 113 determines that at least a portion of the first electrical pulses in the first pulse train are output by the electrode patch 111, the controller 113 controls the pulse generator 112 to output at least another second electrical pulse in the second pulse train to the electrode patch 111.
In this embodiment, the controller 113 controls the pulse generator 112 to output a part of the first pulse sequence (which may include one or more first electrical pulses) to the electrode patch 111, then controls the pulse generator 112 to output a part of the second pulse sequence (which may include one or more second electrical pulses) to the electrode patch 111, and controls the pulse generator 112 to output another part of the second pulse sequence (which may include one or more second electrical pulses) to the electrode patch 111 after the controller 113 controls the pulse generator 112 to output another part of the first pulse sequence (which may include one or more first electrical pulses) to the electrode patch 111.
That is, the second pulse train is not entirely located between two adjacent first electrical pulses of the first pulse train. This is advantageous for increasing the duration of the cooperation of the first pulse sequence and the second pulse sequence, thereby increasing the therapeutic effect.
In some possible embodiments, as shown in fig. 4, the pulse generator is controlled to alternately output the first pulse sequence and the second pulse sequence to the electrode patch, including but not limited to steps S201-S202:
s201: after determining that at least one first electrical pulse in the first pulse sequence is output by the electrode patch, controlling the electrode patch to output at least one second electrical pulse in the second pulse sequence.
Alternatively, after the controller 113 determines that at least one first electrical pulse in the first pulse sequence is output through the electrode patch 111, the controller 113 controls the pulse generator 112 to output at least one second electrical pulse in the second pulse sequence to the electrode patch 111.
S202: and after determining that the first pulse sequence is stopped to be output through the electrode patch, controlling the electrode patch to output at least one other second electric pulse in the second pulse sequence.
Alternatively, after the controller 113 determines that the output of the first pulse sequence through the electrode patch 111 is stopped, the controller 113 controls the pulse generator 112 to output at least another second electric pulse in the second pulse sequence to the electrode patch 111.
In this embodiment, the controller 113 controls the pulse generator 112 to start outputting the first pulse sequence to the electrode patch 111, then controls the pulse generator 112 to start outputting the second pulse sequence to the electrode patch 111, and the controller 113 controls the pulse generator 112 to stop outputting the second pulse sequence to the electrode patch 111 after controlling the pulse generator 112 to stop outputting the first pulse sequence to the electrode patch 111.
That is, the start time of the second pulse train is after the start time of the first pulse train, and the stop time of the second pulse train is also after the stop time of the first pulse train. Therefore, the requirements of target cells with different sizes on the electric field intensity can be met, and the treatment effect is improved.
In some possible embodiments, as shown in fig. 5, the pulse generator is controlled to alternately output the first pulse sequence and the second pulse sequence to the electrode patch, including but not limited to steps S301-S302:
s301: after determining that at least one first electrical pulse in the first pulse sequence is output by the electrode patch, controlling the electrode patch to output at least one second electrical pulse in the second pulse sequence.
Alternatively, after the controller 113 determines that at least one first electrical pulse in the first pulse sequence is output through the electrode patch 111, the controller 113 controls the pulse generator 112 to output at least one second electrical pulse in the second pulse sequence to the electrode patch 111.
S302: and after determining that the second pulse sequence is stopped to be output through the electrode patch, controlling the electrode patch to output at least one other first electric pulse in the first pulse sequence.
Alternatively, after the controller 113 determines that the output of the second pulse train through the electrode patch 111 is stopped, the controller 113 controls the pulse generator 112 to output at least another first electric pulse of the first pulse train to the electrode patch 111.
In this embodiment, the controller 113 controls the pulse generator 112 to start outputting the first pulse sequence to the electrode patch 111, then controls the pulse generator 112 to start outputting the second pulse sequence to the electrode patch 111, and the controller 113 controls the pulse generator 112 to stop outputting the first pulse sequence to the electrode patch 111 after controlling the pulse generator 112 to stop outputting the second pulse sequence to the electrode patch 111.
That is, the start time of the second pulse train is after the start time of the first pulse train, and the stop time of the second pulse train is before the stop time of the first pulse train. This is advantageous in that the first pulse sequence is used as a main pulse for inhibiting cell division or destroying cells, and the second pulse sequence is used as an auxiliary pulse for applying a modulating or exciting effect to the organelle, so as to improve the therapeutic effect.
It should be noted that the output form of the first pulse sequence and the second pulse sequence is not limited to the implementation provided in the above three embodiments.
In some possible embodiments, the electric pulse sequence forms an electric field strength at the electrode patch of not less than 0.1 volts per centimeter and not more than 10 volts per centimeter. The electric pulse train provides such an electric field strength that an effective electric field is induced in dividing cells to inhibit cell division to a certain extent.
In some possible embodiments, the sequence of electrical pulses has a frequency of no less than 50 kilohertz, and no greater than 500 kilohertz. At such frequencies, the electric pulse sequence can induce an electric field in dividing cells, which has a certain inhibition effect on cell division, and can reduce or even eliminate the stimulation effect on non-dividing cells. Thus being beneficial to improving the distinguishing capability of the electric pulse sequence to tumor cells and healthy cells, not only improving the treatment effect, but also greatly reducing the side effect.
Optionally, the sequence of electrical pulses has a frequency of not less than 100 kilohertz and not greater than 300 kilohertz. The frequency of the sequence of electrical pulses is at least 100 khz and no greater than 300 khz, as compared to a range of no less than 50 khz and no greater than 500 khz, which allows the induced electric field to more intensely inhibit certain specific cells.
Optionally, the sequence of electrical pulses has a frequency of not less than 170 kilohertz and not greater than 250 kilohertz. The frequency of the sequence of electrical pulses is not less than 170 khz and not more than 250 khz, which causes the induced electric field to be more concentrated in inhibiting certain cells than is not less than 100 khz and not more than 300 khz.
In some possible embodiments, the sequence of electrical pulses forms an electric field strength at the electrode patch of not less than 1 volt per centimeter and not more than 5 volts per centimeter. Compared with the value range of the electric field intensity of not less than 0.1 volt per centimeter and not more than 10 volts per centimeter, the electric field intensity formed by the electric pulse sequence at the electrode patch is not less than 1 volt per centimeter and not more than 5 volts per centimeter, so that the induced electric field can play a role in inhibiting certain specific cells in a more concentrated manner.
Based on the same inventive concept, the embodiment of the present application provides a control device for a cell division inhibiting device, comprising:
and the electric pulse control module is used for controlling a pulse generator in the cell division inhibiting device to output an electric pulse sequence to the electrode patch so as to inhibit at least part of target cells from dividing or kill at least part of target cells.
In this embodiment, the electric pulse control module may control the pulse generator 112 to output an electric pulse sequence to the electrode patch 111, so that the electrode patch 111 can apply the electric pulse sequence to the tissue of the focal zone, and the electric pulse sequence may apply a potential to the target cell to induce an electric field in the target cell.
For the dividing cells, on one hand, electric field lines induced in the cells are gathered at the equatorial plate, and the organelles are subjected to electric field force directed to the equatorial plate, namely, the electric field force can limit the organelles to move towards two poles, so that certain inhibiting effect on cell division can be achieved.
On the other hand, as the degree of cell division increases (i.e., the equatorial plate narrows), the electric field lines at the equatorial plate become denser, and the increased electric field force can pull the organelles toward the equatorial plate, thus hindering the formation of the cell plate, and further inhibiting cell division, even inducing cell rupture or apoptosis.
On the other hand, the cellular organelles are gathered at the equatorial plate, which causes an increase in the pressure near the equatorial plate, which may rupture the cell membrane, especially in the state of narrowing of the equatorial plate. And the electric pulse sequence can make the organelle receive pulse electric field force, i.e. make the organelle have a certain hammer effect, thus can improve the possibility of rupture of the cell membrane. In addition, the pulsed electric field force applied to the organelles also affects the structures of the organelles, and can induce the disintegration or the rupture of the organelles and further induce the cell rupture or the apoptosis.
Therefore, the control device of the cell division inhibiting device provided by the embodiment of the present application, which is based on the foregoing embodiment, controls the pulse generator 112 to output the electric pulse sequence to the electrode patch 111 through the electric pulse control module, so that the electrode patch 111 can apply the electric pulse sequence to the tissue of the focal region, can inhibit the movement of the organelles in the dividing cells to two poles, even pull the organelles to an equatorial plate, induce the cell to collapse or break, and achieve the effect of inhibiting the cell division or destroying the cell.
In some possible embodiments, the electrical pulse control module is further configured to control the pulse generator to alternately output the first pulse sequence and the second pulse sequence to the electrode patch; the frequency of the first pulse train is different from the frequency of the second pulse train.
In this embodiment, the electric pulse control module controls the pulse generator 112 to alternately output two pulse sequences with different frequencies to the electrode patch 111, which is beneficial to meeting the requirements of target cells with different sizes on the electric field intensity and improving the treatment effect; on the other hand, the fatigue of the cells to the electric pulse sequence with single frequency can be reduced, which is beneficial to continuously realizing effective treatment.
In some possible embodiments, the electrical pulse control module is further configured to control the electrode patch to output at least one second electrical pulse in the second pulse sequence after determining to output at least one first electrical pulse in the first pulse sequence through the electrode patch; after determining that at least one other first electrical pulse in the first pulse sequence is output by the electrode patch, the electrode patch is controlled to output at least one other second electrical pulse in the second pulse sequence.
In this embodiment, the electric pulse control module controls the pulse generator 112 to output a part of the first pulse sequence (the part may include one or more first electric pulses) to the electrode patch 111, then controls the pulse generator 112 to output a part of the second pulse sequence (the part may include one or more second electric pulses) to the electrode patch 111, and controls the pulse generator 112 to output another part of the second pulse sequence (the another part may include one or more second electric pulses) to the electrode patch 111 after the electric pulse control module controls the pulse generator 112 to output another part of the first pulse sequence (the another part may include one or more first electric pulses) to the electrode patch 111.
That is, the second pulse train is not entirely located between two adjacent first electrical pulses of the first pulse train. This is advantageous for increasing the duration of the cooperation of the first pulse sequence and the second pulse sequence, thereby increasing the therapeutic effect.
In some possible embodiments, the electrical pulse control module is further configured to control the electrode patch to output at least one second electrical pulse in the second pulse sequence after determining to output at least one first electrical pulse in the first pulse sequence through the electrode patch; and after determining that the first pulse sequence is stopped to be output through the electrode patch, controlling the electrode patch to output at least one other second electric pulse in the second pulse sequence.
In this embodiment, the electric pulse control module first controls the pulse generator 112 to start outputting the first pulse sequence to the electrode patch 111, then controls the pulse generator 112 to start outputting the second pulse sequence to the electrode patch 111, and after controlling the pulse generator 112 to stop outputting the first pulse sequence to the electrode patch 111, then controls the pulse generator 112 to stop outputting the second pulse sequence to the electrode patch 111.
That is, the start time of the second pulse train is after the start time of the first pulse train, and the stop time of the second pulse train is also after the stop time of the first pulse train. Therefore, the requirements of target cells with different sizes on the electric field intensity can be met, and the treatment effect is improved.
In some possible embodiments, the electrical pulse control module is further configured to control the electrode patch to output at least one second electrical pulse in the second pulse sequence after determining to output at least one first electrical pulse in the first pulse sequence through the electrode patch; and after determining that the second pulse sequence is stopped to be output through the electrode patch, controlling the electrode patch to output at least one other first electric pulse in the first pulse sequence.
In this embodiment, the electric pulse control module first controls the pulse generator 112 to start outputting the first pulse sequence to the electrode patch 111, then controls the pulse generator 112 to start outputting the second pulse sequence to the electrode patch 111, and after controlling the pulse generator 112 to stop outputting the second pulse sequence to the electrode patch 111, then controls the pulse generator 112 to stop outputting the first pulse sequence to the electrode patch 111.
That is, the start time of the second pulse train is after the start time of the first pulse train, and the stop time of the second pulse train is before the stop time of the first pulse train. This is advantageous in that the first pulse sequence is used as a main pulse for inhibiting cell division or destroying cells, and the second pulse sequence is used as an auxiliary pulse for applying a modulating or exciting effect to the organelle, so as to improve the therapeutic effect.
Based on the same inventive concept, embodiments of the present application provide a computer-readable storage medium, which stores a computer program, and the computer program, when executed by a controller, implements any one of the methods for controlling a cell-division suppressing device as provided in the foregoing embodiments.
A computer-readable storage medium provided in the examples of the present application is suitable for various alternative embodiments of the control method of the cell-division suppressing apparatus described above. And will not be described in detail herein.
Those skilled in the art will appreciate that the computer-readable storage media provided by the embodiments can be any available media that can be accessed by the electronic device and includes both volatile and nonvolatile media, removable and non-removable media. The computer-readable storage medium includes, but is not limited to, any type of disk including floppy disks, hard disks, optical disks, CD-ROMs, and magnetic-optical disks, ROMs, RAMs, EPROMs (Erasable Programmable Read-Only memories), EEPROMs (Electrically Erasable Programmable Read-Only memories), flash memories, magnetic cards, or optical cards. That is, a computer-readable storage medium includes any medium that stores or transmits information in a form readable by a device (e.g., a computer).
Based on the same inventive concept, the embodiment of the present application provides a cell division inhibiting system 100, which is schematically shown in fig. 2 and includes: a cell division suppressing device 110, and an upper computer 120, as in any of the embodiments set forth above.
The host computer 120 is in communication with the controller 113 in the cell-division suppressing apparatus 110.
In this embodiment, the upper computer 120 may implement program update or data backup for the ablation device 110, and may also implement remote control for the cell-division inhibiting device 110, thereby facilitating function expansion of the cell-division inhibiting device 110.
Optionally, the host computer 120 is communicatively connected to the controller 113 in the cell-division inhibiting device 110 via WIFI (Wireless Fidelity).
Optionally, the upper computer 120 is communicatively connected to the controller 113 in the cell division suppressing device 110 through the cloud.
By applying the embodiment of the application, at least the following beneficial effects can be realized:
1. in the cell division inhibiting device 110, the controller 113 may control the pulse generator 112 to output an electric pulse sequence to the electrode patch 111, so that the electrode patch 111 may apply the electric pulse sequence to the tissue of the focal region, the electric pulse sequence may apply a potential to the target cell to induce an electric field in the target cell, may inhibit organelles in the dividing cell from moving to two poles, and may even pull the organelles to an equatorial plate to induce cell collapse or rupture, thereby achieving the effect of inhibiting cell division or destroying cells, and the electric pulse sequence may hardly affect the cells which are not divided, thereby improving the ability of distinguishing tumor cells from healthy cells, not only improving the therapeutic effect, but also greatly reducing the side effects.
2. The control method based on the cell division inhibiting device outputs an electric pulse sequence to the electrode patch 111 by controlling the pulse generator 112 of the cell division inhibiting device 110, so that the electrode patch 111 can apply the electric pulse sequence to tissues of a focal region, the electric pulse sequence can apply electric potential to target cells to induce an electric field in the target cells, can inhibit organelles in the dividing cells from moving towards two poles, even can pull the organelles to an equatorial plate to induce the cells to be collapsed or broken, and achieves the effect of inhibiting the cells from being divided or destroying the cells, and the electric pulse sequence hardly causes influence on the cells which are not divided, thereby improving the distinguishing capability of tumor cells and healthy cells, improving the treatment effect and greatly reducing the side effect.
3. The control method based on the cell division inhibiting device alternately outputs two pulse sequences with different frequencies to the electrode patch 111 by controlling the pulse generator 112, so that the requirements of target cells with different sizes on the electric field intensity are met, and the treatment effect is improved; on the other hand, the fatigue of the cells to the electric pulse sequence with single frequency can be reduced, which is beneficial to continuously realizing effective treatment.
4. The control method based on the cell division inhibiting device alternately outputs square wave pulse sequences with different frequencies to the electrode patches 111 by controlling the pulse generator 112, so that the electric potential applied to target cells is stable, the organelles are favorably subjected to constant pulse electric field force, the organelles are favorably drawn towards the equatorial plate, or the cell membranes are favorably hammered by the organelles.
5. The control method based on the cell division inhibiting device is beneficial to improving the matching time length of the first pulse sequence and the second pulse sequence by controlling the second pulse sequence not to be completely positioned between two adjacent first electric pulses of the first pulse sequence, thereby improving the treatment effect.
6. The control method based on the cell division inhibiting device controls the starting time of the second pulse sequence to be behind the starting time of the first pulse sequence and the stopping time of the second pulse sequence to be behind the stopping time of the first pulse sequence, so that the requirements of target cells with different sizes on the electric field intensity can be met, and the treatment effect is improved.
7. The control method by the cell division suppressing apparatus controls the start timing of the second pulse train to be after the start timing of the first pulse train and the stop timing of the second pulse train to be before the stop timing of the first pulse train. This is advantageous in that the first pulse sequence is used as a main pulse for inhibiting cell division or destroying cells, and the second pulse sequence is used as an auxiliary pulse for applying a modulating or exciting effect to the organelle, so as to improve the therapeutic effect.
Those of skill in the art will appreciate that the various operations, methods, steps in the processes, acts, or solutions discussed in this application can be interchanged, modified, combined, or eliminated. Further, other steps, measures, or schemes in various operations, methods, or flows that have been discussed in this application can be alternated, altered, rearranged, broken down, combined, or deleted. Further, steps, measures, schemes in the prior art having various operations, methods, procedures disclosed in the present application may also be alternated, modified, rearranged, decomposed, combined, or deleted.
In the description of the present application, it is to be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the referred device or element must have a particular orientation, be constructed in a particular orientation, and be operated, and thus should not be construed as limiting the present application.
The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless otherwise specified.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.
In the description herein, particular features, structures, materials, or characteristics may be combined in any suitable manner in any one or more embodiments or examples.
It should be understood that, although the steps in the flowcharts of the figures are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and may be performed in other orders unless explicitly stated herein. Moreover, at least a portion of the steps in the flow chart of the figure may include multiple sub-steps or multiple stages, which are not necessarily performed at the same time, but may be performed at different times, which are not necessarily performed in sequence, but may be performed alternately or alternately with other steps or at least a portion of the sub-steps or stages of other steps.
The foregoing is only a partial embodiment of the present application, and it should be noted that, for those skilled in the art, several modifications and decorations can be made without departing from the principle of the present application, and these modifications and decorations should also be regarded as the protection scope of the present application.
Claims (15)
1. A cell-division inhibiting device comprising:
the electrode patch is used for being attached to the surface of skin;
a pulse generator electrically connected to the electrode patch;
a controller, communicatively coupled to the pulse generator, for controlling the pulse generator to output a sequence of electrical pulses to the electrode patch that inhibits division of or kills at least a portion of the target cells.
2. A method for controlling the cell-division suppressing device according to claim 1, comprising:
and controlling a pulse generator in the cell division inhibiting device to output an electric pulse sequence to the electrode patch so as to inhibit at least part of the target cells from dividing or kill at least part of the target cells.
3. The control method according to claim 2, wherein the controlling of the pulse generator in the cell-division suppressing device to output the sequence of electric pulses to the electrode patch includes:
controlling the pulse generator to alternately output a first pulse sequence and a second pulse sequence to the electrode patch; the frequency of the first pulse train is different from the frequency of the second pulse train.
4. The control method of claim 3, wherein at least one of the first pulse train and the second pulse train comprises a square wave pulse train.
5. The control method according to claim 3 or 4, wherein the controlling the pulse generator to alternately output a first pulse sequence and a second pulse sequence to the electrode patch comprises:
controlling the electrode patch to output at least one second electrical pulse in the second pulse sequence after determining that at least one first electrical pulse in the first pulse sequence is output by the electrode patch;
after determining that at least a portion of the first electrical pulses in the first pulse train are output by the electrode patch, controlling the electrode patch to output at least another second electrical pulse in the second pulse train.
6. The control method according to claim 3 or 4, wherein the controlling the pulse generator to alternately output a first pulse sequence and a second pulse sequence to the electrode patch comprises:
controlling the electrode patch to output at least one second electrical pulse in the second pulse sequence after determining that at least one first electrical pulse in the first pulse sequence is output by the electrode patch;
and after determining that the first pulse sequence is stopped to be output through the electrode patch, controlling the electrode patch to output at least another second electric pulse in the second pulse sequence.
7. The control method according to claim 3 or 4, wherein the controlling the pulse generator to alternately output a first pulse sequence and a second pulse sequence to the electrode patch comprises:
controlling the electrode patch to output at least one second electrical pulse in the second pulse sequence after determining that at least one first electrical pulse in the first pulse sequence is output by the electrode patch;
and after determining that the second pulse sequence is stopped to be output through the electrode patch, controlling the electrode patch to output at least another first electric pulse in the first pulse sequence.
8. The method of claim 2, wherein the sequence of electrical pulses forms an electric field strength at the electrode patch of no less than 0.1 volts per centimeter and no greater than 10 volts per centimeter.
9. The control method according to claim 2, wherein the frequency of the sequence of electric pulses is not less than 50 khz and not more than 500 khz.
10. The control method according to claim 2, wherein the frequency of the sequence of electric pulses is not less than 100 khz and not more than 300 khz.
11. The control method of claim 2, wherein the sequence of electrical pulses has a frequency of not less than 170 kilohertz and not greater than 250 kilohertz.
12. The control method of any one of claims 9-11, wherein the sequence of electrical pulses forms an electric field strength at the electrode patch of no less than 1 volt per centimeter and no greater than 5 volts per centimeter.
13. A control device for a cell-division suppressing apparatus, comprising:
and the electric pulse control module is used for controlling a pulse generator in the cell division inhibiting device to output an electric pulse sequence to the electrode patch so as to inhibit at least part of target cells from dividing or kill at least part of target cells.
14. A computer-readable storage medium, in which a computer program is stored, which, when executed by a controller, implements a method of controlling the cell-division suppressing apparatus according to any one of claims 2 to 12.
15. A cell-division inhibiting system comprising: the cell-division suppressing device of claim 1, and a host computer;
the upper computer is in communication connection with a controller in the cell division inhibiting device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110214201.1A CN113018682A (en) | 2021-02-25 | 2021-02-25 | Cell division suppressing device, method, device, system and storage medium for controlling the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110214201.1A CN113018682A (en) | 2021-02-25 | 2021-02-25 | Cell division suppressing device, method, device, system and storage medium for controlling the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113018682A true CN113018682A (en) | 2021-06-25 |
Family
ID=76461844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110214201.1A Pending CN113018682A (en) | 2021-02-25 | 2021-02-25 | Cell division suppressing device, method, device, system and storage medium for controlling the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113018682A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113476746A (en) * | 2021-07-20 | 2021-10-08 | 杭州维纳安可医疗科技有限责任公司 | Equipment, control method and control device for inhibiting division of diseased cells |
| CN113509646A (en) * | 2021-08-13 | 2021-10-19 | 杭州维纳安可医疗科技有限责任公司 | Electrode patch, cell division inhibition device and control method thereof |
| CN113667599A (en) * | 2021-08-19 | 2021-11-19 | 杭州维纳安可医疗科技有限责任公司 | System for inhibiting bacterial proliferation and control method thereof |
| CN113663217A (en) * | 2021-08-19 | 2021-11-19 | 杭州维纳安可医疗科技有限责任公司 | Electric field generation system, control method and device for enhancing tumor treatment field effect |
| CN113663215A (en) * | 2021-10-22 | 2021-11-19 | 杭州维纳安可医疗科技有限责任公司 | Electric field generating apparatus, control method thereof, and computer-readable storage medium |
| CN113694370A (en) * | 2021-08-25 | 2021-11-26 | 杭州维纳安可医疗科技有限责任公司 | Implantable target electric field delivery device |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109124759A (en) * | 2018-09-12 | 2019-01-04 | 上海睿刀医疗科技有限公司 | Cooperate with generation method, device, medium and the electronic equipment of electric impulse signal |
| CN109394334A (en) * | 2018-11-23 | 2019-03-01 | 刘海鹰 | A kind of high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor and system |
| CN110193141A (en) * | 2019-07-03 | 2019-09-03 | 陕西巴赫曼健康产品有限公司 | A kind of tumour electric field treatment system and device |
| CN209392585U (en) * | 2018-02-07 | 2019-09-17 | 张建义 | A kind of electric field bringing device of selective depression specific cells growth |
-
2021
- 2021-02-25 CN CN202110214201.1A patent/CN113018682A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN209392585U (en) * | 2018-02-07 | 2019-09-17 | 张建义 | A kind of electric field bringing device of selective depression specific cells growth |
| CN109124759A (en) * | 2018-09-12 | 2019-01-04 | 上海睿刀医疗科技有限公司 | Cooperate with generation method, device, medium and the electronic equipment of electric impulse signal |
| CN109394334A (en) * | 2018-11-23 | 2019-03-01 | 刘海鹰 | A kind of high-voltage bipolar steep-sided pulse group therapeutic apparatus for treating tumor and system |
| CN110193141A (en) * | 2019-07-03 | 2019-09-03 | 陕西巴赫曼健康产品有限公司 | A kind of tumour electric field treatment system and device |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113476746A (en) * | 2021-07-20 | 2021-10-08 | 杭州维纳安可医疗科技有限责任公司 | Equipment, control method and control device for inhibiting division of diseased cells |
| CN113509646A (en) * | 2021-08-13 | 2021-10-19 | 杭州维纳安可医疗科技有限责任公司 | Electrode patch, cell division inhibition device and control method thereof |
| CN113667599A (en) * | 2021-08-19 | 2021-11-19 | 杭州维纳安可医疗科技有限责任公司 | System for inhibiting bacterial proliferation and control method thereof |
| CN113663217A (en) * | 2021-08-19 | 2021-11-19 | 杭州维纳安可医疗科技有限责任公司 | Electric field generation system, control method and device for enhancing tumor treatment field effect |
| CN113694370A (en) * | 2021-08-25 | 2021-11-26 | 杭州维纳安可医疗科技有限责任公司 | Implantable target electric field delivery device |
| CN113663215A (en) * | 2021-10-22 | 2021-11-19 | 杭州维纳安可医疗科技有限责任公司 | Electric field generating apparatus, control method thereof, and computer-readable storage medium |
| CN113663215B (en) * | 2021-10-22 | 2022-01-21 | 杭州维纳安可医疗科技有限责任公司 | Electric field generating apparatus, control method thereof, and computer-readable storage medium |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN113018682A (en) | Cell division suppressing device, method, device, system and storage medium for controlling the same | |
| CN112842516B (en) | Ablation device, control method, device, system and storage medium thereof | |
| CN112869871B (en) | Ablation device, control method, device, system and storage medium thereof | |
| US11517499B2 (en) | Method for improving kidney function with extracorporeal shockwaves | |
| CA2400526C (en) | Method and apparatus for destroying dividing cells | |
| US20200222728A1 (en) | Boiling Histotripsy Methods and Systems for Uniform Volumetric Ablation of an Object by High-Intensity Focused Ultrasound Waves with Shocks | |
| US6368292B1 (en) | Method for using acoustic shock waves in the treatment of medical conditions | |
| US7016725B2 (en) | Method and apparatus for destroying dividing cells | |
| Elmansy et al. | Recent advances in lithotripsy technology and treatment strategies: A systematic review update | |
| US5245988A (en) | Preparing a circuit for the production of shockwaves | |
| WO2022218312A1 (en) | Pulse control method and apparatus, ablation device and system, and storage medium | |
| US20090131837A1 (en) | Ultrasound Device | |
| WO2024093734A1 (en) | Electric field energy-focused emitting device and method | |
| CN107913477A (en) | A kind of motivational techniques of array ultrasound transducer, device, equipment and storage medium | |
| CN113476742A (en) | System for inhibiting pathological cell division and control method thereof | |
| WO2015153441A1 (en) | Methods and systems for selectively disrupting tissue with high intensity focused ultrasound | |
| KR102320038B1 (en) | Apparatus and method for precise mechanical tissue ablation using pressure modulated focused ultrasound | |
| CN109715079B (en) | Fast pulsed electrohydraulic shock wave generator device with improved electrode life | |
| CN103990233A (en) | Phase control method for high-strength ultrasound transcranial focusing | |
| US20120022374A1 (en) | Pulse wave generator | |
| CN112869872A (en) | Ablation device, control method, device, system and storage medium thereof | |
| Gowrishankar et al. | Intracellular electroporation site distributions: Modeling examples for nsPEF and IRE pulse waveforms | |
| JP6866125B2 (en) | Porous (HYPER-APERTURED) ablation electrode | |
| CN106983537A (en) | A kind of height leads sparking electrode | |
| Vysotsky et al. | Suppression of spiral-wave turbulence by point weak excitations |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20220113 Address after: 310018 room 3318, third floor, international innovation and Expo Center, 267 kekekeyuan Road, Baiyang street, Qiantang District, Hangzhou City, Zhejiang Province Applicant after: Hangzhou Yousheng Medical Technology Co.,Ltd. Address before: 310018 room a0101-21, building 2, 452, Baiyang street, Qiantang New District, Hangzhou City, Zhejiang Province Applicant before: Hangzhou viatech Medical Technology Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20230410 Address after: 310018 room 107-109, room 201-210, room 213-215, building 6, No. 400, Fucheng Road, Xiasha street, Qiantang District, Hangzhou, Zhejiang Province Applicant after: Hangzhou vena Anke Medical Technology Co.,Ltd. Address before: 310018 room 3318, third floor, international innovation and Expo Center, 267 kekekeyuan Road, Baiyang street, Qiantang District, Hangzhou City, Zhejiang Province Applicant before: Hangzhou Yousheng Medical Technology Co.,Ltd. |
|
| TA01 | Transfer of patent application right |