CN113476746A - Equipment, control method and control device for inhibiting division of diseased cells - Google Patents
Equipment, control method and control device for inhibiting division of diseased cells Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract description 22
- 230000000737 periodic effect Effects 0.000 claims abstract description 82
- 230000005684 electric field Effects 0.000 claims abstract description 42
- 238000013461 design Methods 0.000 claims description 16
- 230000001575 pathological effect Effects 0.000 claims description 9
- 230000032823 cell division Effects 0.000 claims description 4
- 230000036285 pathological change Effects 0.000 abstract description 6
- 231100000915 pathological change Toxicity 0.000 abstract description 6
- 230000005764 inhibitory process Effects 0.000 abstract description 3
- 238000010586 diagram Methods 0.000 description 11
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- 230000006870 function Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
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- 238000012986 modification Methods 0.000 description 2
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- 201000011510 cancer Diseases 0.000 description 1
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- 230000007547 defect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
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- 239000000463 material Substances 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
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- A61N1/0472—Structure-related aspects
- A61N1/0492—Patch electrodes
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Abstract
The embodiment of the application provides equipment, a control method and a control device for inhibiting division of diseased cells. The device for inhibiting division of diseased cells comprises: the electric signal generator is used for outputting a non-periodic voltage signal; the electrode patches are used for being attached to a target biological tissue according to a preset mode, and the target biological tissue comprises pathological change cells; and the controller is electrically connected with the electric signal generator and the plurality of groups of electrode patches and is used for controlling the non-periodic voltage signals to be output to the at least two groups of electrode patches so as to form a space electric field at least surrounding the target biological tissue. The electric field that the non-periodic voltage signal that this application embodiment adopted formed between each group of electrode paster is more complicated changeable to the division of effectual inhibition pathological change cell improves treatment.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to equipment, a control method and a control device for inhibiting division of diseased cells.
Background
At present, the method and the device for Treating the lesion cells by using the electric Field can form a space electric Field at the lesion cells, and when the lesion cells are tumors, the electric Field used is a Tumor treatment Field (Tumor Treating Field) or a TT Field. The TT field is capable of preventing proliferation and destruction of rapidly proliferating viable cells (e.g., cancer cells).
However, the effect of the electric field output by the existing apparatus on the inhibition of division of diseased cells is not significant, so that the therapeutic effect is poor.
Disclosure of Invention
The application provides equipment, a control method and a control device for inhibiting pathological cell division aiming at the defects of the existing mode, and aims to solve the technical problems that the effect of an electric field output by the existing equipment on inhibiting pathological cell division is not obvious in the prior art, and the treatment effect is poor.
In a first aspect, the present embodiments provide an apparatus for inhibiting division of diseased cells, including:
the electric signal generator is used for outputting a non-periodic voltage signal;
the electrode patches are used for being attached to a target biological tissue according to a preset mode, and the target biological tissue comprises pathological change cells;
and the controller is electrically connected with the electric signal generator and the plurality of groups of electrode patches and is used for controlling the non-periodic voltage signals to be output to the at least two groups of electrode patches so as to form a space electric field at least surrounding the target biological tissue.
In one possible implementation, the controller is further configured to convert the non-periodic voltage signal into at least two voltage signals, each voltage signal corresponding to a group of the electrode patches; each voltage signal is a different non-periodic voltage signal.
In one possible implementation, the controller is further configured to convert the non-periodic voltage signal into at least two first voltage signals, each first voltage signal corresponding to a group of the electrode patches; the phases of the first voltage signals are different; or,
the controller is also used for converting the non-periodic voltage signals into at least two second voltage signals, and each second voltage signal corresponds to one group of electrode patches; the voltage and phase of each second voltage signal are different.
In one possible implementation, the controller is further configured to control the non-periodic voltage signals to be output to the at least two sets of electrode patches simultaneously.
In one possible implementation, the controller is further configured to control the non-periodic voltage signals to be sequentially output to the electrode patches according to a design sequence.
In one possible implementation, the at least two sets of electrode patches include a first set of electrode patches and a second set of electrode patches;
the controller comprises a first control unit and a second control unit;
the first control unit is electrically connected with the first group of electrode patches and used for converting the non-periodic voltage signals into first non-periodic voltage signals and outputting the first non-periodic voltage signals to the first group of electrode patches;
and the second control unit is electrically connected with the second group of electrode patches and used for converting the non-periodic voltage signals into second non-periodic voltage signals and outputting the second non-periodic voltage signals to the second group of electrode patches.
In one possible implementation, the field strength of the space electric field ranges from 1 v/cm to 10 v/cm; and/or the presence of a gas in the gas,
the frequency of the space electric field is in the range of 50 khz to 500 khz.
In one possible implementation, the electrical signal generator is a pulsed voltage generator or an alternating voltage generator.
In a second aspect, the embodiments of the present application provide a control method for inhibiting division of diseased cells, comprising:
the non-periodic voltage signals output by the electric signal generator are controlled to be output to at least two groups of electrode patches so as to form a space electric field at least surrounding the target biological tissue; the at least two groups of electrode patches are attached to the target biological tissue according to a preset mode, and the target biological tissue comprises pathological change cells.
In one possible implementation, the non-periodic voltage signal output by the control electric signal generator is output to at least two groups of electrode patches, including at least one of the following:
converting the non-periodic voltage signal into at least two voltage signals, each voltage signal corresponding to a group of electrode patches; each voltage signal is different non-periodic voltage signals, and the phase and/or voltage of each voltage signal are different;
controlling the non-periodic voltage signals to be output to at least two groups of electrode patches simultaneously;
and controlling the non-periodic voltage signals to be sequentially output to each group of electrode patches according to a design sequence.
In a third aspect, embodiments of the present application further provide a control device for inhibiting division of diseased cells, including:
the control module is used for controlling the non-periodic voltage signals output by the electric signal generator to be output to at least two groups of electrode patches so as to form a space electric field at least surrounding the target biological tissue; the at least two groups of electrode patches are attached to the target biological tissue according to a preset mode, and the target biological tissue comprises pathological change cells.
In a fourth aspect, embodiments of the present application further provide a computer-readable storage medium for storing computer instructions, which, when executed on an electronic device, implement the control method for inhibiting division of diseased cells according to the second aspect.
The beneficial technical effects brought by the technical scheme provided by the embodiment of the application comprise:
the electric signal generator of the embodiment of the application can output non-periodic voltage signals, and the controller can control the non-periodic voltage signals to be output to at least two groups of electrode patches so as to form a space electric field at least surrounding target biological tissues. The electric field that the non-periodic voltage signal that this application embodiment adopted formed between each group of electrode paster is more complicated changeable to the division of effectual inhibition pathological change cell improves treatment.
Additional aspects and advantages of the present application will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the present application.
Drawings
The foregoing and/or additional aspects and advantages of the present application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
FIG. 1 is a schematic structural diagram of an apparatus for inhibiting division of diseased cells according to an embodiment of the present disclosure;
FIG. 2 is a schematic structural diagram of another apparatus for inhibiting division of diseased cells according to an embodiment of the present disclosure;
FIG. 3 is a waveform diagram of a first aperiodic voltage signal provided by an embodiment of the present application;
FIG. 4 is a waveform diagram of a second non-periodic voltage signal according to an embodiment of the present disclosure;
FIG. 5 is a flow chart of a control method for inhibiting division of diseased cells according to an embodiment of the present application;
fig. 6 is a schematic structural diagram of a control device for inhibiting division of diseased cells according to an embodiment of the present application.
Reference numerals:
100-a device for inhibiting division of diseased cells;
110-an electrical signal generator;
120-electrode patches, 121-first set of electrode patches, 122-second set of electrode patches;
130-controller, 131-first control unit, 132-second control unit.
600-control means to inhibit division of diseased cells, 610-control module.
Detailed Description
Reference will now be made in detail to the present application, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar parts or parts having the same or similar functions throughout. In addition, if a detailed description of the known art is not necessary for illustrating the features of the present application, it is omitted. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present application and are not to be construed as limiting the present application.
It will be understood by those within the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. It will be understood that when an element is referred to as being "connected" or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may also be present. Further, "connected" or "coupled" as used herein may include wirelessly connected or wirelessly coupled. As used herein, the term "and/or" includes all or any element and all combinations of one or more of the associated listed items.
The following describes the technical solutions of the present application and how to solve the above technical problems with specific embodiments.
The embodiment of the present application provides an apparatus for inhibiting division of diseased cells, and referring to fig. 1, the apparatus 100 for inhibiting division of diseased cells includes: an electrical signal generator 11010, at least two sets of electrode patches 120, and a controller 130.
The electrical signal generator 110 is used to output a non-periodic voltage signal.
The at least two sets of electrode patches 120 are configured to be attached to a target biological tissue according to a predetermined manner, wherein the target biological tissue includes lesion cells.
The controller 130 is electrically connected to both the electrical signal generator 110 and the plurality of sets of electrode patches 120, and is configured to control the non-periodic voltage signals to be output to at least two sets of electrode patches 120 to form a spatial electric field at least surrounding the target biological tissue.
The inventor of the present application has found that the conventional electrical signal generator 110 outputs periodic voltage signals, and the frequency of the periodic voltage signals is relatively single, so that the complexity of the electric field is relatively small. Further research by the inventors of the present application has found that the more complex the spatial electric field, the better the therapeutic effect.
The electrical signal generator 110 of the embodiment of the present application can output a non-periodic voltage signal, and the controller 130 can control the non-periodic voltage signal to be output to at least two sets of electrode patches 120 to form a spatial electric field at least surrounding the target biological tissue. The electric field formed between each group of electrode patches 120 by adopting the non-periodic voltage signals is more complex and changeable, so that the division of pathological cells is effectively inhibited, and the treatment effect is improved.
In some embodiments, the controller 130 is further configured to convert the aperiodic voltage signal into at least two voltage signals, each voltage signal corresponding to a set of electrode patches 120; each voltage signal is a different non-periodic voltage signal.
In some embodiments, the controller 130 is further configured to convert the aperiodic voltage signal into at least two first voltage signals, each first voltage signal corresponding to a set of electrode patches 120; the phases of the first voltage signals are different.
Alternatively, the phases of the first voltage signals are different, so that the voltage signals received by the electrode patches 120 have phase differences, which can generate complex spatial electric fields.
Optionally, the voltages of the first voltage signals are the same, and the first voltage signals with phases different by about 90 ° in two or three directions form a spatial electric field, so that the therapeutic effect of the spatial electric field is enhanced.
Optionally, the controller 130 is further configured to convert the aperiodic voltage signal into at least two second voltage signals, each second voltage signal corresponding to a set of the electrode patches 120; the voltage and phase of each second voltage signal are different.
Optionally, the voltage and the phase of each second voltage signal are different, and each second voltage signal output by each electrode patch 120 may be adjusted according to actual needs, so as to form a required spatial electric field and ensure a therapeutic effect.
In some embodiments, the controller 130 is further configured to control the non-periodic voltage signals to be output to at least two sets of electrode patches 120 simultaneously.
Optionally, each set of electrode patches 120 simultaneously receives the non-periodic voltage signal while forming the electric field to form a spatial electric field at least surrounding the target biological tissue.
Alternatively, the non-periodic voltage signal received by each set of electrode patches 120 may be the non-periodic voltage signal output by the electrical signal generator 110, or may be at least two voltage signals converted from the non-periodic voltage signal, such as at least two first voltage signals or at least two second voltage signals.
In some embodiments, the controller 130 is further configured to control the non-periodic voltage signals to be sequentially output to the sets of electrode patches 120 according to a design order.
Optionally, each set of electrode patches 120 sequentially receives the non-periodic voltage signal, so that each set of electrode patches 120 sequentially has an electric field to form a spatial electric field distributed divergently along multiple directions, thereby ensuring a therapeutic effect.
In some embodiments, referring to fig. 2, the at least two sets of electrode patches 120 include a first set of electrode patches 121 and a second set of electrode patches 122.
The controller 130 includes a first control unit 131 and a second control unit 132.
The first control unit 131 is electrically connected to the first group of electrode patches 121, and is configured to convert the aperiodic voltage signal into a first aperiodic voltage signal and output the first aperiodic voltage signal to the first group of electrode patches 121.
The second control unit 132 is electrically connected to the second group of electrode patches 122, and is configured to convert the aperiodic voltage signal into a second aperiodic voltage signal, and output the second aperiodic voltage signal to the second group of electrode patches 122.
Alternatively, as an example, referring to fig. 3, a waveform diagram of a first aperiodic voltage signal is shown; referring to fig. 4, a waveform diagram of the second aperiodic voltage signal is shown.
Alternatively, the first aperiodic voltage signal may also be the waveform shown in fig. 4, and the second aperiodic voltage signal may also be the waveform shown in fig. 3.
In some embodiments, the field strength of the spatial electric field ranges from 1 volt/cm to 10 volts/cm; and/or the frequency of the spatial electric field is in the range of 50 kHz to 500 kHz.
In some embodiments, the electrical signal generator 110 is a pulsed voltage generator or an alternating voltage generator.
Optionally, the pulse voltage generator outputs a pulse voltage to form a pulse electric field.
Alternatively, the alternating voltage generator outputs an alternating voltage, forming an alternating electric field.
Based on the same inventive concept, the embodiment of the present application provides a control method for inhibiting pathological cell division, which includes:
the non-periodic voltage signals output by the control electric signal generator 110 are output to at least two groups of electrode patches 120 to form a spatial electric field at least surrounding the target biological tissue; the at least two sets of electrode patches 120 are attached to the target biological tissue according to a predetermined manner, and the target biological tissue includes lesion cells.
Optionally, the controller 130 controls the non-periodic voltage signals output by the electrical signal generator 110 to be output to at least two sets of electrode patches 120 to form a spatial electric field at least surrounding the target biological tissue.
In some embodiments, the non-periodic voltage signals output by the control electrical signal generator 110 are output to at least two sets of electrode patches 120, including at least one of:
converting the non-periodic voltage signal into at least two voltage signals, each voltage signal corresponding to a set of electrode patches 120; each voltage signal is different non-periodic voltage signals, and the phase and/or voltage of each voltage signal are different;
controlling the non-periodic voltage signals to be output to at least two groups of electrode patches 120 simultaneously;
the non-periodic voltage signals are controlled to be sequentially output to the electrode patches 120 according to a design sequence.
Optionally, the controller 130 converts the aperiodic voltage signal into at least two voltage signals, each voltage signal corresponding to a set of electrode patches 120; each voltage signal is a different non-periodic voltage signal, and the phase and/or voltage of each voltage signal are different.
Optionally, the controller 130 controls the aperiodic voltage signal to be output to at least two sets of electrode patches 120 at the same time.
Alternatively, the controller 130 controls the aperiodic voltage signals to be sequentially output to the electrode patches 120 in a designed order.
Alternatively, referring to fig. 5, as an example, there is shown a control method for inhibiting division of diseased cells, comprising the steps of:
s501, converting the non-periodic voltage signal output by the electrical signal generator 110 into at least two voltage signals, each voltage signal corresponding to a group of electrode patches 120; each voltage signal is a different non-periodic voltage signal, and the phase and/or voltage of each voltage signal are different.
Alternatively, the controller 130 converts the non-periodic voltage signal output by the electrical signal generator 110 into at least two voltage signals, each voltage signal corresponding to a set of the electrode patches 120.
Optionally, the at least two sets of electrode patches 120 comprise a first set of electrode patches 121 and a second set of electrode patches 122.
Optionally, converting the non-periodic voltage signal output by the electrical signal generator 110 into at least two voltage signals, each voltage signal corresponding to a set of electrode patches 120, comprises:
converting the aperiodic voltage signal into a first aperiodic voltage signal by the first control unit 131;
the aperiodic voltage signal is converted into a second aperiodic voltage signal by the second control unit 132.
And S502, controlling at least two voltage signals to be correspondingly output to at least two groups of electrode patches 120 at the same time.
Optionally, the controller 130 controls at least two voltage signals to be output to at least two sets of electrode patches 120 simultaneously.
Optionally, controlling at least two voltage signals to be correspondingly output to at least two sets of electrode patches 120 at the same time includes: the first aperiodic voltage signal is output to the first set of electrode patches 121 while the second aperiodic voltage signal is output to the second set of electrode patches 122.
Alternatively, the first non-periodic voltage signal is controlled by the first control unit 131 to be output to the first group of electrode patches 121, and the second non-periodic voltage signal is controlled by the second control unit 132 to be output to the second group of electrode patches 122.
And S503, controlling at least two voltage signals to be sequentially output to the electrode patches 120 according to a design sequence.
Alternatively, the controller 130 controls at least two voltage signals to be sequentially output to the electrode patches 120 in a design order.
Optionally, controlling at least two voltage signals to be sequentially output to each electrode patch 120 according to a design sequence includes:
and controlling the first non-periodic voltage signal to be output to the first group of electrode patches 121, and controlling the second non-periodic voltage signal to be output to the second group of electrode patches 122 after a first design time.
Optionally, controlling at least two voltage signals to be sequentially output to each electrode patch 120 according to a design sequence includes:
and controlling the second aperiodic voltage signal to be output to the second group of electrode patches 122, and controlling the first aperiodic voltage signal to be output to the first group of electrode patches 121 after a second design time.
Optionally, the first control unit 131 controls the first aperiodic voltage signal to be output to the first group of electrode patches 121, and the second control unit 132 controls the second aperiodic voltage signal to be output to the second group of electrode patches 122 after a first design time interval.
Optionally, the second control unit 132 controls the second aperiodic voltage signal to be output to the second group of electrode patches 122, and the first control unit 131 controls the first aperiodic voltage signal to be output to the first group of electrode patches 121 after a second design time interval.
Based on the same inventive concept, the present application also provides a control device for inhibiting division of diseased cells, as shown in fig. 6, the control device 600 for inhibiting division of diseased cells includes: and a control module 610.
The control module 610 is used for controlling the non-periodic voltage signals output by the electrical signal generator 110 to be output to at least two groups of electrode patches 120 so as to form a spatial electric field at least surrounding the target biological tissue; the at least two sets of electrode patches 120 are attached to the target biological tissue according to a predetermined manner, and the target biological tissue includes lesion cells.
Optionally, the control module 610 is further configured to convert the aperiodic voltage signal into at least two voltage signals, each voltage signal corresponding to a set of electrode patches 120; each voltage signal is a different non-periodic voltage signal, and the phase and/or voltage of each voltage signal are different.
Optionally, the control module 610 is further configured to control the aperiodic voltage signal to be output to at least two groups of electrode patches 120 at the same time;
optionally, the control module 610 is further configured to control the non-periodic voltage signals to be sequentially output to the electrode patches 120 according to a design sequence.
Based on the same inventive concept, embodiments of the present application further provide a computer-readable storage medium for storing computer instructions, which when executed on an electronic device, implement the control method for inhibiting division of diseased cells according to the embodiments of the present application.
It should be noted that the computer readable medium of the present application can be a computer readable signal medium or a computer readable storage medium or any combination of the two. A computer readable storage medium may be, for example, but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the foregoing. More specific examples of the computer readable storage medium may include, but are not limited to: an electrical connection having one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.
In embodiments of the present application, a computer readable storage medium may be any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device. In this application, however, a computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated data signal may take many forms, including, but not limited to, electro-magnetic, optical, or any suitable combination thereof. A computer readable signal medium may also be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to: electrical wires, optical cables, RF (radio frequency), etc., or any suitable combination of the foregoing.
The computer-readable medium of the embodiments of the present application may be embodied in an electronic device; or may be present alone without being incorporated into the electronic device.
Alternatively, a computer-readable medium of an embodiment of the present application carries one or more programs, which, when executed by the electronic device, cause the electronic device to: receiving a node evaluation request comprising at least two internet protocol addresses; selecting an internet protocol address from at least two internet protocol addresses; returning the selected internet protocol address; wherein the received internet protocol address indicates an edge node in the content distribution network.
Computer program code for carrying out operations for embodiments of the present application may be written in any combination of one or more programming languages, including but not limited to an object oriented programming language such as Java, Smalltalk, C + +, and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any type of network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet service provider).
The flowchart and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present application. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s). It should also be noted that, in some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems which perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.
The modules or units described in the embodiments of the present application may be implemented by software or hardware. Wherein the designation of a module or unit does not in some cases constitute a limitation of the unit itself.
The functions described herein above may be performed, at least in part, by one or more hardware logic components. For example, without limitation, exemplary types of hardware logic components that may be used include: field Programmable Gate Arrays (FPGAs), Application Specific Integrated Circuits (ASICs), Application Specific Standard Products (ASSPs), systems on a chip (SOCs), Complex Programmable Logic Devices (CPLDs), and the like.
In the context of embodiments of the present application, a machine-readable medium may be a tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device. The machine-readable medium may be a machine-readable signal medium or a machine-readable storage medium. A machine-readable medium may include, but is not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any suitable combination of the foregoing. More specific examples of a machine-readable storage medium would include an electrical connection based on one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.
By applying the embodiment of the application, at least the following beneficial effects can be realized:
(1) the electric field formed by the non-periodic voltage signals among the electrode patches 120 is more complex and changeable, so that the division of pathological cells is effectively inhibited, and the treatment effect is improved.
(2) The phase and/or voltage of the voltage signals output to each group of electrode patches 120 are different, so that a complex space electric field can be generated, the division of pathological cells is further effectively inhibited, and the treatment effect is improved.
(3) The embodiment of the application can output non-periodic voltage signals to each group of electrode patches 12 at the same time, or sequentially output non-periodic voltage signals to each group of electrode patches 120 according to the design sequence, so as to form a required space electric field and ensure the treatment effect.
Those of skill in the art will appreciate that the various operations, methods, steps in the processes, acts, or solutions discussed in this application can be interchanged, modified, combined, or eliminated. Further, other steps, measures, or schemes in various operations, methods, or flows that have been discussed in this application can be alternated, altered, rearranged, broken down, combined, or deleted. Further, steps, measures, schemes in the prior art having various operations, methods, procedures disclosed in the present application may also be alternated, modified, rearranged, decomposed, combined, or deleted.
The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless otherwise specified.
In the description herein, particular features, structures, materials, or characteristics may be combined in any suitable manner in any one or more embodiments or examples.
It should be understood that, although the steps in the flowcharts of the figures are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and may be performed in other orders unless explicitly stated herein. Moreover, at least a portion of the steps in the flow chart of the figure may include multiple sub-steps or multiple stages, which are not necessarily performed at the same time, but may be performed at different times, which are not necessarily performed in sequence, but may be performed alternately or alternately with other steps or at least a portion of the sub-steps or stages of other steps.
The foregoing is only a partial embodiment of the present application, and it should be noted that, for those skilled in the art, several modifications and decorations can be made without departing from the principle of the present application, and these modifications and decorations should also be regarded as the protection scope of the present application.
Claims (12)
1. An apparatus for inhibiting division of diseased cells, comprising:
the electric signal generator is used for outputting a non-periodic voltage signal;
at least two groups of electrode patches which are used for being attached to a target biological tissue according to a preset mode, wherein the target biological tissue comprises the pathological cells;
and the controller is electrically connected with the electric signal generator and the plurality of groups of electrode patches and is used for controlling the non-periodic voltage signals to be output to at least two groups of electrode patches so as to form a space electric field at least surrounding the target biological tissue.
2. The apparatus for inhibiting division of diseased cells according to claim 1 wherein the controller is further configured to convert the non-periodic voltage signal into at least two voltage signals, each of the voltage signals corresponding to a set of the electrode patches; each of the voltage signals is a different non-periodic voltage signal.
3. The apparatus for inhibiting division of diseased cells according to claim 2, wherein the controller is further configured to convert the non-periodic voltage signal into at least two first voltage signals, each of the first voltage signals corresponding to a set of the electrode patches; the phases of the first voltage signals are different; or,
the controller is further configured to convert the aperiodic voltage signal into at least two second voltage signals, each of the second voltage signals corresponding to a set of the electrode patches; the voltage and the phase of each second voltage signal are different.
4. The apparatus for suppressing diseased cell division according to claim 1 wherein the controller is further configured to control the non-periodic voltage signals to be output to at least two of the sets of electrode patches simultaneously.
5. The apparatus for suppressing division of diseased cells according to claim 1, wherein the controller is further configured to control the non-periodic voltage signals to be sequentially output to each of the electrode patches in a design order.
6. The apparatus for inhibiting division of diseased cells according to claim 1, wherein the at least two sets of electrode patches include a first set of electrode patches and a second set of electrode patches;
the controller comprises a first control unit and a second control unit;
the first control unit is electrically connected with the first group of electrode patches and is used for converting the aperiodic voltage signal into a first aperiodic voltage signal and outputting the first aperiodic voltage signal to the first group of electrode patches;
the second control unit is electrically connected with the second group of electrode patches and used for converting the non-periodic voltage signals into second non-periodic voltage signals and outputting the second non-periodic voltage signals to the second group of electrode patches.
7. The apparatus for inhibiting division of diseased cells according to claim 1 wherein the field strength of the spatial electric field is in the range of 1 to 10 volts/cm; and/or the presence of a gas in the gas,
the frequency of the space electric field is in the range of 50 kHz to 500 kHz.
8. The apparatus for inhibiting division of diseased cells according to claim 1, wherein the electrical signal generator is a pulsed voltage generator or an alternating voltage generator.
9. A control method for inhibiting division of diseased cells, comprising:
the non-periodic voltage signals output by the electric signal generator are controlled to be output to at least two groups of electrode patches so as to form a space electric field at least surrounding the target biological tissue; and at least two groups of the electrode patches are attached to the target biological tissue according to a preset mode, and the target biological tissue comprises the pathological cells.
10. The method of claim 9, wherein the non-periodic voltage signals output by the electrical signal generator are output to at least two groups of the electrode patches, and the method comprises at least one of:
converting the non-periodic voltage signals into at least two voltage signals, each voltage signal corresponding to a set of the electrode patches; each voltage signal is different non-periodic voltage signals, and the phase and/or voltage of each voltage signal are different;
controlling the non-periodic voltage signals to be output to at least two groups of the electrode patches simultaneously;
and controlling the non-periodic voltage signals to be sequentially output to the electrode patches of each group according to a design sequence.
11. A control device for inhibiting division of diseased cells, comprising:
the control module is used for controlling the non-periodic voltage signals output by the electric signal generator to be output to at least two groups of electrode patches so as to form a space electric field at least surrounding the target biological tissue; and at least two groups of the electrode patches are attached to the target biological tissue according to a preset mode, and the target biological tissue comprises the pathological cells.
12. A computer-readable storage medium for storing computer instructions for implementing the control method for inhibiting division of diseased cells according to any one of claims 9 to 10 when the computer instructions are executed on an electronic device.
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