CN112501015A

CN112501015A - Device for inhibiting or destroying tumor cell division

Info

Publication number: CN112501015A
Application number: CN202011538284.1A
Authority: CN
Inventors: 郑庆杰
Original assignee: Shenzhen Aopaisen Bioelectromagnetic Technology Co ltd
Current assignee: Shenzhen Aopaisen Bioelectromagnetic Technology Co ltd
Priority date: 2020-12-23
Filing date: 2020-12-23
Publication date: 2021-03-16

Abstract

The invention provides a device for inhibiting or destroying tumor cell division, which comprises at least one pair of body surface conductive electrodes, and is characterized by further comprising at least one group of square wave voltage sources with outputs, wherein the square wave voltage sources output square wave signals, the outputs of the square wave voltage sources are electrically connected with the body surface conductive electrodes, and the body surface conductive electrodes are provided with at least one surface used for being placed close to the body surface corresponding to a target area of a patient. The surface of at least one pair of body surface conductive electrodes is abutted against the body surface corresponding to the target area of the patient, and then the square wave voltage source is started, so that the tumor cells are positioned in the square wave electric field emitted by the square wave voltage source, the microtubules are interfered to break, mitosis cannot be completed, and the effect of inhibiting or destroying the division of the tumor cells is realized.

Description

Device for inhibiting or destroying tumor cell division

Technical Field

The invention relates to the technical field of medical treatment, in particular to a device for inhibiting or destroying tumor cell division.

Background

Electric field therapy is a physical therapy based on bioelectrical effects. As early as 2001, the York professor Youlim Paier, college of Israel, developed for the first time a new therapy for treating brain tumors with low-intensity electric fields. The "electric field" is not an electric current flowing through body tissue, nor is it ionizing radiation that directly attacks tissue cells, as in X-rays and gamma rays. An "electric field" is actually a "force field" that can act on a charged substance, and can attract or repel charged particles, thereby affecting the distribution and movement of the particles.

A large characteristic of tumor cells is uncontrolled mitosis, i.e., the genetic material located in the nucleus, chromosomes, are constantly replicating and then split into two parts and are completely unregulated by the body to replicate-divide-reproduce-reclassify … …, however, the cellular mitosis process requires the involvement of tubulin and its polymers, a specific protein in the cytoplasm. These proteins are arranged uniformly in the middle of the cell in the early stages of cell division, and then are three-dimensionally ordered and capable of end-to-end association to form polymer chains. Finally, these polymer chains pull the chromosomes from one cell into two, completing mitosis.

Based on this, there is a need to provide a device that inhibits or disrupts mitosis in tumor cells.

Disclosure of Invention

It is an object of the present invention to provide a device for inhibiting or disrupting tumor cell division to solve the existing problem of uncontrolled mitosis of tumor cells.

The invention provides a device for inhibiting or destroying tumor cell division, which comprises at least one pair of body surface conductive electrodes, and is characterized by further comprising at least one group of square wave voltage sources with outputs, wherein the square wave voltage sources output square wave signals, the outputs of the square wave voltage sources are electrically connected with the body surface conductive electrodes, and the body surface conductive electrodes are provided with at least one surface used for being placed close to the body surface corresponding to a target area of a patient.

Furthermore, the body surface conductive electrodes are provided with two or more pairs, and the square wave voltage source is provided with two or more groups of outputs.

Further, the surface comprises an inner surface and an outer surface, wherein the inner surface is proximate to a body surface corresponding to the target area, and the field strength between the inner surfaces of each pair of the body surface conductive electrodes ranges from 0.1v/cm to 12 v/cm.

Further, the frequency of the square wave signal is 1kHz-10 MHz.

Further, the square wave voltage source comprises a DC/AC circuit and a signal distribution circuit, and the signal distribution circuit is electrically connected between the DC/AC circuit and the body surface conductive electrodes.

Further, the square wave voltage source is provided with two or more DC/AC circuits connected in parallel, and the output of each DC/AC circuit is electrically connected with each pair of body surface conductive electrodes.

Further, the voltage, the frequency and the duty ratio of the DC/AC circuit are adjustable.

Further, the square wave voltage source further comprises a DC/DC circuit, an output of the DC/DC circuit is an input of the DC/AC circuit, and the DC/DC circuit is a step-up type, a step-down type or a step-up and step-down type.

Further, the signal distribution circuit is a switching device-based signal distribution circuit.

Further, the absolute value of the voltage amplitude of the square wave signal does not exceed 48V.

The invention has the beneficial effects that: the surface of at least one pair of body surface conductive electrodes is abutted against the body surface corresponding to the target area of the patient, and then the square wave voltage source is started, so that the tumor cells are positioned in the square wave electric field emitted by the square wave voltage source, the microtubules are interfered to break, mitosis cannot be completed, and the effect of inhibiting or destroying the division of the tumor cells is realized.

Drawings

FIG. 1 is a schematic structural diagram of an apparatus for inhibiting or disrupting tumor cell division according to a first embodiment of the present invention;

FIG. 2 is a schematic structural diagram of an apparatus for inhibiting or disrupting tumor cell division according to a second embodiment of the present invention;

FIG. 3 is a schematic diagram of the structure of a DC/AC circuit in an apparatus for inhibiting or disrupting tumor cell division according to a third embodiment of the invention;

FIG. 4 is a schematic diagram of one configuration of a DC/DC circuit in the apparatus for inhibiting or disrupting tumor cell division of the present invention;

FIG. 5 is a graph of an inverted square wave output from the apparatus for inhibiting or disrupting tumor cell division according to the present invention;

FIG. 6 is a graph of the driving signals in the device for inhibiting or disrupting tumor cell division of the present invention;

FIG. 7 is a schematic diagram of a signal distribution circuit in the apparatus for inhibiting or disrupting tumor cell division according to the present invention;

FIG. 8 is a schematic diagram of the structure of a DC/AC circuit in an apparatus for inhibiting or disrupting tumor cell division according to a fourth embodiment of the present invention;

FIG. 9 is another schematic diagram of the signal distribution circuit in the apparatus for inhibiting or disrupting tumor cell division according to the present invention;

description of the main element symbols:

first body meter conductive electrode	10	Second body surface conductive electrode	40	Signal distribution circuit	23
						First surface	11	Second surface	12	First switch tube	231
Square wave voltage source	20	Transformer device	219	Second switch tube	232
						DC/AC circuit	21	DC/DC circuit	22	Third switch tube	233
First MOS transistor	211	First inductor	221	Fourth switch tube	234
						Second 212	212	Fifth MOS transistor	222	First relay	235
Third MOS transistor	213	First diode	223	Second relay	236
						Fourth MOS transistor	214	First capacitor	224	Direct current source	30

The following detailed description will further illustrate the invention in conjunction with the above-described figures.

Detailed Description

To facilitate an understanding of the invention, the invention will now be described more fully with reference to the accompanying drawings. Several embodiments of the invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

A first embodiment of the present invention (as shown in fig. 1) provides an apparatus for inhibiting or destroying tumor cell division, the apparatus comprising a pair of body surface conductive electrodes (a first body surface conductive electrode 10, a second body surface conductive electrode 40), and a square wave voltage source 20 having an output, the square wave voltage source 20 outputting a square wave signal, the output of the square wave voltage source 20 being electrically connected to the first body surface conductive electrode 10 and the second body surface conductive electrode 40, the first body surface conductive electrode 10 having a first surface 11 for placement against a body surface corresponding to a target region of a patient; the second body surface conductive electrode 40 has a second surface 12 for placement against a body surface corresponding to the target region of the patient.

In other embodiments, the first body conductive electrode 10 may have two or more first surfaces 11 for placement against a body surface corresponding to a target region of a patient; the second body surface conductive electrode 40 may have two or more second surfaces 12 for placement against a body surface corresponding to the target region of the patient.

The first surface 11 and the second surface 12 respectively have an inner surface and an outer surface, the inner surface is an electric conductor (such as silica gel, PET, etc.), and is used for being close to the body surface corresponding to the target region when in use; the outer surface is an insulator; the conductive heads (not shown) of the first body surface conductive electrode 10 and the second body surface conductive electrode 40 respectively penetrate through the outer surfaces of the first surface 11 and the second surface 12 and then contact the inner surfaces of the first surface and the second surface.

Specifically, in the present embodiment, a first surface 11 and a second surface 12 constitute a pair of surfaces, and the field strength between the inner surfaces of each pair of surfaces ranges from 0.1v/cm to 12 v/cm.

Specifically, in this embodiment, the frequency of the square wave signal is 1kHz to 10MHz, so as to form a square wave electric field.

Specifically, in the present embodiment, the square wave voltage source 20 may be provided with a dc source such as a battery as its power supply, or may be provided with a dc source such as an external battery.

Referring to fig. 2, according to a second embodiment of the present invention, there are two pairs of body surface conductive electrodes, each pair of body surface conductive electrodes (body surface conductive electrode pair) is composed of a first body surface conductive electrode 10 and a second body surface conductive electrode 40, the first body surface conductive electrode 10 has at least one first surface 11, the second body surface conductive electrode 40 has at least one second surface 12, the number of the square wave voltage sources 20 is two, so as to increase the strength of the square wave electric field, the more the number of the specific body surface conductive electrode pairs is, the more the square wave voltage sources 20 are required to supply power, and the more the number of the body surface conductive electrode pairs is, the larger the area of the square wave electric field is formed.

It is understood that in other embodiments of the present invention, at least one pair of body surface conductive electrodes may be disposed according to the requirement of the user, specifically, the larger the volume of the solid tumor is, the more pairs of body surface conductive electrodes are required. Accordingly, a corresponding number of square wave voltage sources 20 are arranged to supply power according to the number of pairs of body surface conductive electrodes, for example, N pairs (N ═ 1,2,3 … …), so that N sets of square wave voltage sources 20 are provided.

The number of the pairs of the body surface conductive electrodes is consistent with that of the square wave voltage sources, namely the number of the pairs of the body surface conductive electrodes and the number of the square wave voltage sources are required, each square wave voltage source is provided with a group of outputs, and the group of outputs are connected with a pair of body surface conductive electrodes; in fact, a combination of a square wave voltage source 20 and a signal distribution circuit may be used to implement multiple sets of outputs, each set of outputs connected to each pair of body surface conductive electrodes.

When the number of the square wave voltage sources 20 is plural, the plural square wave voltage sources 20 may adopt any one or any several of alternative operation, overlapping operation, and partially overlapping operation, as required.

Referring to fig. 3, in the third embodiment of the present invention, the square wave voltage source 20 includes a DC/AC circuit 21, the input side of the DC/AC circuit 21 is connected to a DC source such as a battery, the DC/AC circuit 21 is a full-bridge inverter and includes a first MOS transistor 211, a second MOS transistor 212, a third MOS transistor 213, and a fourth MOS transistor 214, the first MOS transistor 211 and the second MOS transistor 212 are connected in series to form a first bridge arm, the third MOS transistor 213 and the fourth MOS transistor 214 are connected in series to form a second bridge arm, the first bridge arm and the second bridge arm are connected in parallel, and the midpoint of the first bridge arm and the midpoint of the second bridge arm respectively form two output ends of the square wave voltage source 20. In other embodiments of the present invention, an output filter circuit may be added if the output waveform is to be changed. It is understood that the MOS transistor may be replaced by an IGBT, a triode, or other types of switching transistors.

Specifically, the first MOS transistor 211 and the fourth MOS transistor 214 are a group and are turned on and off simultaneously; the third MOS tube 213 and the second MOS tube 212 are a group and are turned on and off simultaneously; the two groups of MOS switching tubes are alternately conducted to output inversion square waves under the driving of the driving signals, a square wave diagram is shown in FIG. 5, and further, the absolute value of the voltage amplitude of the square wave signals does not exceed 48V; preferably, the absolute value of the voltage amplitude of the square wave signal does not exceed 24V. The driving signal diagram is shown in fig. 6. in one embodiment, the voltage amplitude of the driving signal is 12-15V.

It is understood that, in other embodiments, the DC/AC circuit 21 may also be a half-bridge inverter circuit, an I-type inverter circuit, a T-type inverter circuit, or the like.

Further, the square wave voltage source 20 may further include a DC/DC circuit 22 (as shown in fig. 4), an output of the DC/DC circuit 22 being an input of the DC/AC circuit, and an input of the DC/DC circuit being an input of the square wave voltage source 20. As shown in fig. 4, the input end of the DC/DC circuit 22 is connected to the DC source 30, the first inductor 221, the fifth MOS transistor 222, the first diode 223 and the first capacitor 224, two ends of the first capacitor 224 are the output of the DC/DC circuit 22, one end of the first inductor 221 is connected to the positive terminal of the DC source 60, the other end of one end of the first inductor 221 is connected to the positive electrode of the first diode 223 and the drain of the fifth MOS transistor 222, respectively, the source of the fifth MOS transistor 222 and the negative terminal of the first capacitor 224 are connected to the negative terminal of the DC source 30, and the negative electrode of the first diode 223 is connected to the positive terminal of the first capacitor 224, so as to form a boost DC regulator circuit. It is understood that the fifth MOS transistor 222 may be replaced by an IGBT or other switching transistor.

It is understood that the DC/DC circuit 22 may also be a buck DC regulator circuit, or a buck DC regulator circuit.

Further, the square wave voltage source 20 may further include a signal distribution circuit 23, the signal distribution circuit 23 is electrically connected between the DC/AC circuit 21 and the body surface conductive electrode, that is, when the input of the signal distribution circuit 23 is the output of the DC/AC circuit 21, the output of the signal distribution circuit 23 is the output of the square wave voltage source 20; the signal distribution circuit 23 converts a pair of outputs of the DC/AC circuit 21 into pairs of outputs, which are then connected to the surface conductive electrode pairs, respectively.

Specifically, the amplitude of the circuit voltage can be adjusted through the DC/DC circuit 22, inversion, duty ratio adjustment, voltage adjustment and frequency adjustment can be realized through the DC/AC circuit 21, and then square wave signals are distributed to the surface conductive electrodes 10 through the signal distribution circuit 23.

Specifically, in the present embodiment, the signal distribution circuit 23 (as shown in fig. 7) includes a first switch tube 231, a second switch tube 232, a third switch tube 233, and a fourth switch tube 234, when the four switching tubes are mosfets, the drain of the first switching tube 231 is connected to the output end of the DC/AC circuit 21, the source of the first switching tube 231 is connected to the source of the second switching tube 232, the drain of the third switch tube 233 is connected to the output end of the DC/AC circuit 21, the source of the third switch tube 233 is connected to the source of the fourth switch tube 234, the drain of the second switch tube 232, the drain of the fourth switch tube 234 and the other end of the output of the DC/AC circuit 21 form two groups of outputs V21, V22 of the signal distribution circuit 23, respectively, so as to distribute signals to different loads (each body surface conductive electrode pair) by switching on and off the four switch tubes.

Specifically, in the present embodiment, the signal distribution circuit 23 is a bidirectional switching tube-based signal distribution circuit.

Referring to fig. 8, in a fourth embodiment of the present invention, a square wave voltage source 20 includes the DC/AC circuit, the DC/AC circuit shown in fig. 8 has one more transformer 219 compared with the DC/AC circuit shown in fig. 3, two ends of a primary coil of the transformer 219 are connected to a middle point of a first bridge arm and a middle point of a second bridge arm, two ends of a secondary coil of the transformer 219 are outputs of the square wave voltage source 20, and an isolated inverter circuit is formed by using the transformer 219 to invert an output square wave; in other embodiments of the present invention, an output filter circuit may be added if the output waveform is to be changed. In this embodiment, the duty cycle and frequency of the DC/AC circuit are adjustable; the peak value of the output voltage can be adjusted by the transformer transformation ratio.

Specifically, in this embodiment, further, the square wave voltage source 20 further includes a signal distribution circuit (as shown in fig. 9), in fig. 9, the signal distribution circuit includes a first relay 235 and a second relay 236, an input of the signal distribution circuit is an output of the DC/AC circuit 21, one end of the first relay 235 and one end of the second relay 236 are both connected to one output end of the DC/AC circuit 21, the other end of the first relay 235 and the other end of the second relay 236 are respectively connected to the other output end of the DC/AC circuit 21 to form two sets of outputs V21 and V22 of the signal distribution circuit, each set of outputs V21 and V22 of the signal distribution circuit are respectively connected to a pair of conductive electrodes, so that signal distribution is achieved through switching of the relays. Specifically, in this embodiment, the signal distribution circuit is a relay-based signal distribution circuit.

In other embodiments of the present invention, the signal distribution circuit may also be a signal distribution circuit based on a contactor or other types of switching devices, and only the bidirectional switch tube or the relay needs to be replaced by the contactor or other types of switching devices, respectively.

In other embodiments of the present invention, the square wave voltage source 20 has two or more DC/AC circuits 21 connected in parallel, and the output of each DC/AC circuit 21 is electrically connected to each pair of body surface conductive electrodes.

In a specific implementation process, the voltage, the frequency and the duty ratio of the DC/AC circuit 21 are adjustable, so as to adjust the intensity of the square wave electric field according to the user requirement.

The working principle or process is as follows: the device for inhibiting or destroying tumor cell division is realized by placing the first surface 11 and the second surface 12 of at least one pair of surface conductive electrodes against the surface of a target area of a patient body, then starting the square wave voltage source 20, using the square wave voltage source 20 for a certain time (for example, 2-24 hours) every day, then turning off the square wave voltage source 20, removing the first surface 11 and the second surface 12 from the surface of the target area of the patient body, and repeating the steps by taking the day as a unit, so that the tumor cells are positioned in the square wave electric field emitted by the square wave voltage source 20 (specifically, the tumor cells are positioned in the square wave electric field between the inner surfaces of the first surface 11 and the second surface 12).

The invention has the beneficial effects that: the first surface 11 and the second surface 12 of at least one pair of body surface conductive electrodes are abutted against the body surface corresponding to the target area of the patient, and then the square wave voltage source 20 is started, so that the tumor cells are positioned in the square wave electric field emitted by the square wave voltage source 20, the microtubules are disturbed to break, mitosis cannot be completed, and the effect of inhibiting or destroying the division of the tumor cells is realized; the invention adopts the square wave voltage source 20, the dv/dt output by the square wave is larger, and the effect of inhibiting the tumor cells is better from the perspective of electromagnetic force.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. An apparatus for inhibiting or disrupting tumor cell division, the apparatus comprising at least one pair of body surface conductive electrodes, and further comprising a square wave voltage source having at least one set of outputs, the square wave voltage source outputting a square wave signal, the square wave voltage source outputs being electrically connected to the body surface conductive electrodes, the body surface conductive electrodes having at least one surface for placement against a corresponding body surface of a target region of a patient.

2. The apparatus of claim 1, wherein there are two or more pairs of surface conductive electrodes and the square wave voltage source has two or more sets of outputs.

3. The apparatus of claim 1 or 2, wherein the surface comprises an inner surface and an outer surface, wherein the inner surface is proximate to a body surface corresponding to the target area, and wherein the field strength between the inner surfaces of each pair of the body surface conductive electrodes is in a range of 0.1v/cm to 12 v/cm.

4. The device for inhibiting or destroying tumor cell division according to any one of claims 1 to 3, wherein said square wave signal has a frequency of 1kHz-10 MHz.

5. The apparatus of claim 2, wherein the square wave voltage source comprises a DC/AC circuit and a signal distribution circuit electrically connected between the DC/AC circuit and the body surface conductive electrodes.

6. The apparatus of claim 5, wherein the square wave voltage source has two or more DC/AC circuits connected in parallel, the output of each DC/AC circuit electrically connecting each pair of body surface conductive electrodes.

7. The apparatus according to claim 5 or 6, wherein the DC/AC circuit is adjustable in voltage, frequency, duty cycle.

8. The device of claim 5 or 6, wherein the square wave voltage source further comprises a DC/DC circuit, the output of the DC/DC circuit being the input of the DC/AC circuit, the DC/DC circuit being a step-up, step-down or step-up/step-down type.

9. The apparatus for inhibiting or disrupting tumour cell division according to claim 3, the signal distribution circuitry being switching device based.

10. The device for inhibiting or disrupting tumour cell division according to any of claims 1 to 3, wherein the voltage amplitude of the square wave signal does not exceed 48V in absolute terms.