CN115970155A - Metal substrate electrode, tumor electric field treatment electrode and system - Google Patents
Metal substrate electrode, tumor electric field treatment electrode and system Download PDFInfo
- Publication number
- CN115970155A CN115970155A CN202310284480.8A CN202310284480A CN115970155A CN 115970155 A CN115970155 A CN 115970155A CN 202310284480 A CN202310284480 A CN 202310284480A CN 115970155 A CN115970155 A CN 115970155A
- Authority
- CN
- China
- Prior art keywords
- electrode
- metal substrate
- copper
- electric field
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Electrotherapy Devices (AREA)
Abstract
The invention provides a metal substrate electrode which comprises a copper-coated circuit layer, a first insulating layer arranged at the lower end of the copper-coated circuit layer, a metal substrate arranged at the lower end of the first insulating layer, wherein the copper-coated circuit layer is provided with a first copper-coated circuit layer, a second copper-coated circuit layer and a third copper-coated circuit layer, the first copper-coated circuit layer is used for being connected with an electrode, the second copper-coated circuit layer and the third copper-coated circuit layer are used for being connected with a temperature sensor, and a solder-resisting film layer is arranged above the copper-coated circuit layer. Above-mentioned metal substrate electrode, metal substrate can form the oxide layer that the one deck is fine and close to by itself in the air, can play fine insulating effect and heat conduction, and the effectual scald user skin of having avoided, metal substrate can realize self-healing function after sharp ware is damaged, because the thermal resistance of metal substrate, first insulation layer is all very little, can directly put temperature sensor in covering copper line layer and need not sink the formula and press close to the skin design, and the uniformity is better.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a metal substrate electrode, a tumor electric field treatment electrode and a tumor electric field treatment system.
Background
The Tumor electric field therapy is called Tumor Treating Fields in English, and TTF is the acronym in English. Initially for the treatment of malignant brain gliomas. 2019, the electric field treatment of tumor has approved new indications, and can be used for treating malignant pleural mesothelioma. The trade name was not very similar and the length was slightly different depending on the treatment site.
The existing tumor electric field treatment device can cause micro-current due to the direct action of an electric field on human tissues, the micro-current can cause heat effect, and discomfort and skin scalding risks are brought to the human body.
Disclosure of Invention
The invention aims to provide a tumor electric field treatment system to solve the problem that the existing tumor electric field treatment device has the risk of scalding skin.
The invention provides a metal substrate electrode which comprises a copper-coated circuit layer, a first insulating layer arranged at the lower end of the copper-coated circuit layer and a metal substrate arranged at the lower end of the first insulating layer, wherein the copper-coated circuit layer is provided with a first copper-coated circuit layer, a second copper-coated circuit layer and a third copper-coated circuit layer, the first copper-coated circuit layer is used for being connected with an electrode, the second copper-coated circuit layer and the third copper-coated circuit layer are used for being connected with a temperature sensor, and a solder mask layer is arranged above the copper-coated circuit layer.
Above-mentioned metal substrate electrode, metal substrate can form the compact metal oxide layer of one deck in the air by itself, can play fine insulating effect and heat conduction, and effectual scald user skin of having avoided, metal substrate can realize self-healing function after sharp ware is damaged, because the thermal resistance of metal substrate, first insulation layer is all very little, can directly put temperature sensor in covering copper line layer and need not sink the formula and press close to the skin design, and the uniformity is better.
Furthermore, the metal substrate electrode further comprises a second insulating layer and a conducting layer, the second insulating layer is located below the metal substrate, and the conducting layer is located below the second insulating layer.
Further, the metal substrate electrode is in contact with the skin through a conductive gel.
Further, the thickness of the conductive gel is 0.1-5mm.
Furthermore, the tail end of the copper-clad circuit layer is provided with a wiring terminal, the electrode wire and the temperature sensor are connected with the copper-clad circuit layer through the wiring terminal,
furthermore, the peripheries of the wiring terminal and the solder mask layer are provided with insulating potting layers.
Further, the connecting terminal is a pad or a socket.
Furthermore, the surface of the metal substrate electrode is provided with an air-permeable adhesive tape.
Further, the area of the lower surface of the metal substrate electrode is not more than 50cm 2 。
Further, the first insulating layer comprises epoxy glue and ceramic powder, and the mass ratio of the epoxy glue to the ceramic powder is 1.
Further, the metal substrate is one of an aluminum substrate, a copper substrate and an iron substrate.
The invention also provides a tumor electric field treatment electrode which is characterized in that at least two metal substrate electrodes respectively form a first electrode and a second electrode, the first electrode and the second electrode form a pair of electrodes, the first electrode is connected with the first electrode wire, and the second electrode is connected with the second electrode wire.
The invention also provides a tumor electric field treatment system, which comprises a human-computer interaction interface, a control unit, a power supply unit, a voltage amplitude regulating circuit, an inverse frequency modulation circuit, a signal distribution circuit and a tumor electric field treatment electrode.
Furthermore, the tumor electric field treatment electrodes are multiple, and the signal distribution circuit distributes the multiple tumor electric field treatment electrodes in a time-sharing manner;
the temperature sensor on the tumor electric field treatment electrode is connected with the control unit;
the control unit is used for controlling the power supply unit, the voltage amplitude regulating circuit, the inverter frequency modulation circuit, the signal distribution circuit and the tumor electric field treatment electrode;
the power supply unit is used for supplying power to the tumor electric field treatment system;
the voltage amplitude regulating circuit, the inverter frequency modulation circuit and the signal distribution circuit are sequentially connected in series;
the tumor electric field treatment system sets control parameters through a human-computer interaction interface, and the control unit controls and modulates the output voltage of the power supply unit, the output voltage of the voltage amplitude regulating circuit, the output frequency of the inverter frequency modulation circuit and the scanning period of the signal distribution circuit to enable the output voltage to reach the control parameters, and monitors, prewarns and protects the temperature of the tumor electric field treatment electrode.
Furthermore, the first electrode and the second electrode respectively comprise a plurality of metal substrate electrodes with the same quantity, the plurality of metal substrate electrodes are arranged in an array, and two adjacent metal substrate electrodes are connected with each other.
Drawings
FIG. 1-1 is a schematic structural diagram of a metal substrate electrode according to an embodiment of the present invention;
FIGS. 1-2 are schematic structural views of a metal substrate electrode according to still another embodiment of the present invention;
FIG. 2 is a schematic structural diagram of an electric field treatment electrode for treating tumor according to an embodiment of the present invention;
FIG. 3 is a schematic structural diagram of an electric field tumor therapy system according to an embodiment of the present invention;
FIG. 4 is a schematic diagram of the connection structure of the control unit, the signal distribution circuit and the metal substrate electrode in the electric field tumor therapy system in FIG. 3;
FIG. 5 is a schematic diagram of a connection structure of a control unit, a signal distribution circuit and a metal substrate electrode in the electric field tumor therapy system according to an embodiment of the present invention;
fig. 6 is a schematic view of a connection structure of a control unit, a signal distribution circuit and a metal substrate electrode in the electric field tumor therapy system according to an embodiment of the present invention.
FIG. 7 is an equivalent circuit diagram of the tumor electric field treatment system according to an embodiment of the present invention.
FIG. 8 is an equivalent circuit diagram of an electric field tumor therapy system according to another embodiment of the present invention.
Description of the main element symbols:
| copper- |
10 | Connecting |
60 | Based on a metal substrate
Tumor electricity of electrode
|
300 |
| Conductive vias | 11 | |
80 | |
301 |
| Mounting hole | 12 | Permeable |
90 | Power supply unit | 302 |
| A first |
20 | |
100 | Voltage amplitude |
303 |
| |
30 | Based on a metal substrate
Tumor electricity of electrode
|
200 | Inverter |
304 |
| |
40 | First |
201 | |
305 |
| Temperature sensor | 50 | Second |
202 | Human-computer interaction interface | 306 |
| A second |
2 | |
3 |
The following detailed description will further illustrate the invention in conjunction with the above-described figures.
Description of the preferred embodiment
To facilitate an understanding of the invention, the invention will now be described more fully with reference to the accompanying drawings. Several embodiments of the invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like are used herein for purposes of illustration only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Referring to fig. 1-1, a metal substrate electrode 100 according to an embodiment of the present invention includes a copper-clad circuit layer 10, a first insulating layer 20 disposed at a lower end of the copper-clad circuit layer 10, a metal substrate 30 disposed at a lower end of the first insulating layer 20, a conductive gel 40 disposed at a lower end of the metal substrate 30, and a temperature sensor disposed above the copper-clad circuit layer 10.
It can be understood that copper-clad circuit layer 10 has first, second, third copper-clad circuit layer, first copper-clad circuit layer is used for connecting the electrode, second, third copper-clad circuit layer are used for connecting temperature sensor's one end and the other end respectively, and copper-clad circuit layer 10 surface is equipped with hinders the rete.
Specifically, the terminals of the first, second and third copper-clad circuit layers are provided with wiring terminals 60, and the electrodes and the temperature sensors are connected with the corresponding copper-clad circuit layers through the wiring terminals.
Preferably, after the electrode wire and the temperature sensor are connected, the wiring terminal 60 and the periphery of the solder mask layer are provided with insulating encapsulating layers for coating the connection part of the electrode wire and the first copper-clad circuit layer, the wiring terminal 60, the solder mask layer and the temperature sensor so as to realize the protection functions of fixing, insulating, waterproof, dampproof, dustproof and the like, and the insulating encapsulating layers can be formed by encapsulating epoxy, silica gel or other materials.
It is understood that the terminals are pads or sockets, for example, in one case, the terminals 60 at the ends of the first, second and third copper-clad circuit layers are all pads, and then one end of the connecting wire is welded to the pad at the end of the first copper-clad circuit layer, and two ends of the temperature sensor are respectively welded to the pads at the ends of the second and third copper-clad circuit layers; in another case, the terminal 60 at the end of the first copper-clad circuit layer is a pad, the terminal 60 at the end of the second copper-clad circuit layer is a socket, and at this time, one end of the connecting wire is welded to the pad at the end of the first copper-clad circuit layer, and two ends of the temperature sensor are respectively inserted into the sockets at the ends of the second copper-clad circuit layer and the third copper-clad circuit layer; for the form of the connecting terminal, the form is not listed, and in fact, the connecting terminal can be matched with the connecting wire and the temperature sensor.
It is understood that the metal substrate 30 may be any one of an aluminum substrate, a copper substrate, an iron substrate, or other metal substrate. The aluminum substrate has good heat dissipation performance and relatively low price; the heat dissipation performance of the copper substrate is better than that of the aluminum substrate, but the price is expensive; the iron substrate is the lowest in price and poor in heat dissipation performance, but is easier to oxidize to form an oxide insulating layer.
The metal substrate electrode can form a compact metal oxide layer in the air (for example, when the metal substrate is an aluminum substrate, the metal oxide layer is Al2O 3), so that the metal substrate electrode can play a good role in insulation and heat conduction in use, the skin of a user is effectively prevented from being scalded, and meanwhile, the metal substrate 30 can realize a self-repairing function after the edge tool is damaged; in addition, because the thermal resistances of the metal substrate 30, the first insulating layer 20 and the conductive gel 40 are very small, the temperature sensor can be directly placed on the electrode surface of the metal substrate without sinking to the skin, and the consistency is better.
Note that the conductive gel 40 may be omitted; when the conductive gel 40 is not provided, the lower surface of the metal substrate 30 is in contact with the skin in the treatment process, and when the conductive gel 40 is used, the conductive gel 40 is in direct contact with the skin, and the skin tolerance can be ensured because the conductive gel has the modulus similar to that of the skin.
The thickness of the conductive gel 40 can be selected according to the actual need, and in one embodiment, the thickness of the conductive gel is 0.1-5mm.
In one embodiment of the present invention, the surface of the metal substrate electrode is provided with a permeable adhesive tape 90 to fix the metal substrate electrode 100 on the surface of the human body, and more specifically, the upper surface of the metal substrate electrode 100 is attached to the permeable adhesive tape 90, so that the lower surface of the metal substrate electrode 100 is in contact with/attached to the surface of the human body.
In one embodiment of the present invention, the maximum area of the lower surface of the single metal substrate electrode 100 is not more than 50cm 2 Because the skin smoothness is not good, the area of the single metal substrate electrode 100 is not too large, so that the single metal substrate electrode can be in close contact with the skin; the shape of the metal substrate electrode 100 can be customized according to the location and size of the tumor of the patient, and can be circular, square, polygonal or irregular.
In one embodiment of the present invention, the first insulating layer 20 includes epoxy glue and ceramic powder to perform an insulating function. In one embodiment, the mass ratio of the epoxy glue to the ceramic powder is 1.
In an embodiment of the present invention, the first insulating layer 20 has a relatively high dielectric constant, good insulating performance, and a relatively small thickness, and can be formed by spraying an insulating paint or pasting an insulating film.
In one embodiment of the present invention, the temperature sensor is a thermistor to achieve the temperature detection function, but when the temperature is detected to be too high (for example, the temperature exceeds 40 ℃), the human body may be uncomfortable or the skin may be injured, the system sends out an over-temperature alarm and stops to perform heat dissipation and cooling, and the system is restarted after the temperature is reduced to a certain degree.
Referring to fig. 1-2, according to a metal substrate electrode 100 provided by another embodiment of the present invention, compared with the embodiment shown in fig. 1-2, the embodiment shown in fig. 1-2 further includes a second insulating layer 2 and a conductive layer 3, the second insulating layer 2 and the conductive layer 3 are located between the metal substrate 30 and the conductive gel 40, wherein the second insulating layer 2 is located below the metal substrate 30, and the conductive layer 3 is located below the second insulating layer 2 and above the conductive gel 40; the benefits of this arrangement are: the second insulating layer 2 can better prevent the surface layer of the metal substrate 30 from being oxidized, and meanwhile, in order to realize that the electric field transmits energy in a capacitive mode, one conductive layer 3 is added, so that the metal substrate 30, the second insulating layer 2 and the conductive layer 3 form another capacitive structure (capacitor).
In the embodiment shown in fig. 1-2, wherein the conductive layer 3 may be a metal substrate, the conductive gel 40 may be omitted; when the conductive gel 40 is not provided, the lower surface of the conductive layer 3 is in contact with the skin in the treatment process, when the conductive gel 40 is used, the conductive gel 40 is in direct contact with the skin, and the conductive gel has the modulus similar to that of the skin, so that the conductive gel can be in more complete contact with the surface of the skin, and the tolerance of the skin is ensured.
Preferably, the second insulating layer 2 is a metal oxide insulating layer; preferably, the second insulating layer 2 has a thickness of 0.01-10 microns, and the thickness of the conductive gel can be controlled by passivation or other processes.
It is understood that the second insulating layer 2 may also cover the side of the metal substrate 30 at the same time for better insulation.
Referring to fig. 2, an embodiment of the present invention further provides a tumor electric field treatment electrode 200, in which at least two metal substrate electrodes 100 respectively form a first electrode (positive electrode) and a second electrode (negative electrode), the first electrode and the second electrode form a pair of electrodes, the first electrode is connected to a first electrode line 201, and the second electrode is connected to a second electrode line 202.
It is understood that, in addition to the first electrode and the second electrode respectively including one metal substrate electrode, in some embodiments, the first electrode and the second electrode respectively include a plurality of metal substrate electrodes of the same number, a plurality of metal substrate electrodes belonging to the same electrode are arranged in an array and are all connected to the same electrode line, for example, two adjacent metal substrate electrodes are connected to each other and then connected to the first electrode line/the second electrode line; for example, in fig. 5, the first electrode and the second electrode each include 2 metal substrate electrodes, and in fig. 6, one electrode includes 9 metal substrate electrodes; the number of the metal substrate electrodes in the first electrode and the second electrode can be set according to actual needs, for example, when the tumor is larger, a larger number of metal substrate electrodes can be used, conversely, when the tumor is smaller, a smaller number of metal substrate electrodes can be set, and so on.
In addition, above-mentioned tumour electric field treatment electrode 200, metal substrate 30 self can form the compact metal oxide layer of one deck in the air, can play fine insulating effect and heat conduction effect, the effectual scald user skin of having avoided, metal substrate 30 can realize self-repair function after sharp weapon damage simultaneously, because metal substrate 30, 20 layers of thermal resistances of first insulation are all very little, can directly put temperature sensor on metal substrate electrode 100's surface, and do not need the formula of sinking to press close to the skin design, the uniformity is better.
Referring to fig. 3, an embodiment of the present invention further provides a tumor electric field treatment system 300, which includes a control unit 301, a power supply unit 302, a voltage amplitude adjusting circuit 303, an inverse frequency modulation circuit 304, and a signal distribution circuit 305, and further includes at least one tumor electric field treatment electrode 200 as described above, wherein each signal distribution circuit 304 is respectively connected to one of the tumor electric field treatment electrodes 200;
the tumor electric field treatment electrode 200 is also connected with the control unit 301;
the control unit 301 is used for controlling the power supply unit 302, the voltage amplitude adjusting circuit 303, the inverse frequency modulation circuit 304, the signal distribution circuit 305 and the tumor electric field treatment electrode;
the power supply unit 302 is configured to supply power to the tumor electric field therapy system, for example, an output end of the power supply unit 302 is direct current, and the power supply unit 302 supplies power to the voltage amplitude adjusting circuit 303, the control unit 301, and the human-computer interaction interface 306; the voltage amplitude adjusting circuit 303 adjusts the voltage and/or amplitude of the direct current obtained from the power supply unit 302, outputs the adjusted direct current to the inverter frequency modulation circuit 304, the inverter frequency modulation circuit 304 converts the received direct current into alternating current and performs frequency modulation (changes the frequency), the inverted and frequency-modulated alternating current is connected to the tumor electric field treatment electrodes 200 through the signal distribution circuit 305, and each tumor electric field treatment electrode 200 has a pair of electrodes; when the tumor electric field treatment electrode is multiple, the signal distribution circuit 304 distributes the multiple tumor electric field treatment electrodes in a time-sharing manner, that is, the signal distribution circuit 304 alternately energizes the multiple pairs of electrodes in a time-sharing manner, for example, a first pair of electrodes is energized in a first time period, a second pair of electrodes is energized in a second time period, and so on.
The human-computer interface 306 can be used for setting control parameters (such as voltage, frequency, scanning period, and temperature threshold), and controlling and modulating the output voltage of the power supply unit 302, the output voltage of the voltage amplitude adjusting circuit 303, the output frequency of the inverse frequency modulation circuit 304, the scanning period of the signal distribution circuit 305, and the like through the control unit 301 to reach the control parameters, so as to monitor, pre-warn, and protect the temperature of the tumor electric field treatment electrode.
The voltage amplitude adjusting circuit 303, the inverter frequency modulation circuit 304, and the signal distribution circuit 305 are sequentially connected in series.
Specifically, the two ends of the temperature sensor are connected to the control unit 301, and the control unit 301 obtains the temperature of the metal substrate electrode 100 according to the change of the temperature sensor, and performs corresponding control.
The control unit 301 may be a PLC controller, and the PLC controller is provided with a human-computer interface 306 to artificially control the operation parameters of each component.
Above-mentioned tumour electric field treatment system 300, metal substrate 30 self can form the compact oxide layer of one deck in the air, can play fine insulating effect and heat conduction, the effectual user skin of scalding of having avoided, metal substrate 30 can realize the self-healing function after sharp weapon damage simultaneously, because metal substrate 30, the thermal resistance on 20 layers of first insulation is all very little, can directly put temperature sensor on metal substrate electrode 100 upper surface and need not sink the formula and press close to the skin design, the uniformity is better.
In the embodiment of the present invention, the power supply unit 302 may be a built-in battery or an external adapter (ac/dc adapter) connected to the mains for supplying power.
In the embodiment of the present invention, the number of the signal distribution circuits 305 is the same as that of the tumor electric field treatment electrodes 200, so as to realize the separate control of each tumor electric field treatment electrode, and further realize the different output powers of the tumor electric field treatment electrodes at different positions.
In the embodiment of the tumor electric field treatment system 300 shown in fig. 4, one tumor electric field treatment electrode 200 is provided, and the one tumor electric field treatment electrode 200 comprises two metal substrate electrodes 100, and the two metal substrate electrodes 100 respectively form a first electrode (positive electrode) and a second electrode (negative electrode).
Referring to fig. 3 and 5, in a tumor electric field treatment system 300 according to another embodiment of the present invention, in the present embodiment, one tumor electric field treatment electrode 200 is provided, and the one tumor electric field treatment electrode 200 includes 4 metal substrate electrodes 100, wherein first electrode ends of two metal substrate electrodes 100 are connected together to form a positive electrode of the tumor electric field treatment electrode 200, and second electrode ends of the other two metal substrate electrodes 100 are connected together to form a negative electrode of the tumor electric field treatment electrode 200. The metal substrate 30 in the above-mentioned tumour electric field treatment electrode 200 can itself form the metal oxide layer that the one deck is fine and close to in the air, can play fine insulating effect and heat conduction, the effectual scald user skin of having avoided, metal substrate 30 can realize the self-healing function after sharp weapon damage simultaneously, because metal substrate 30, the thermal resistance on 20 layers of first insulation is all very little, can directly put temperature sensor on metal substrate electrode 100 upper surface and need not sink the formula and press close to the skin design, the uniformity is better.
Referring to fig. 3 and 6, in another embodiment of the tumor electric field treatment system 300 based on metal substrate electrodes according to the present invention, there are nine metal substrate electrodes 100 corresponding to the positive and negative electrodes of one tumor electric field treatment electrode 200, fig. 6 only shows the metal substrate electrode 100 corresponding to the positive electrode (+), and the same applies to the metal substrate electrode 100 corresponding to the negative electrode (-); nine metal substrate electrodes 100 are arranged in an array, and the electrode ends of the adjacent metal substrate electrodes 100 are connected with each other to form a redundant structure, so that even if one of the metal substrate electrodes 100 is disconnected, the electrode ends of the other metal substrate electrodes 100 are still connected with each other; it is understood that, in addition to fig. 6, the connection manner between the metal substrate electrodes 100 may be other connection manners, for example, the electrode terminal of each metal substrate electrode 100 is connected to the electrode terminals of other metal substrates adjacent to the electrode terminal, or the electrode terminal of each metal substrate electrode 100 is directly connected to an electrode line, etc., as long as the connection of the electrode terminal of each metal substrate electrode 100 to the electrode line is finally achieved.
It is understood that, in order to increase the effect and avoid the bad contact of the single metal substrate electrode 100, an array structure may be adopted, each array includes several metal substrate electrodes 100 (for example, in fig. 6, one array includes 9 metal substrate electrodes 100; in fig. 5, one array includes 2 metal substrate electrodes 100), the electrode ends of the metal substrate electrodes 100 in each array are connected together to form a redundant structure, the number and shape of the metal substrate electrodes 100 in each array can be customized according to the position and size of the tumor of the patient, a certain gap is provided between the metal substrate electrodes in each array for ventilation, and a temperature sensor, i.e., a thermistor 50, is placed on the upper surface of the metal substrate electrodes 100 for detecting the skin temperature and preventing the skin from being damaged due to too high temperature. The array formed by the metal substrate electrodes 100 forms redundancy, the failure of the metal substrate electrodes 100 caused by the fact that a certain line is disconnected or broken can be avoided, the array formed by the metal substrate electrodes 100 is fixed at the skin of the body surface of a patient through the external air-permeable adhesive tape 90, and the skin contact allergy can be avoided by regularly replacing and cleaning the surface of the array. Both ends of each metal substrate electrode 100 connected to the temperature controller are connected to the control unit 301, and the electrode end of the positive electrode metal substrate electrode 100 on each positive electrode array is connected to the first electrode line of the signal distribution circuit 305; the negative electrode metal substrate electrodes 100 on each negative electrode array are connected in series with each other and then connected to the second electrode lines of the signal distribution circuit 305.
Referring to fig. 7, fig. 7 is an equivalent circuit diagram of a tumor electric field treatment system according to an embodiment of the invention. Which is suitable for use in the metal substrate electrode of the embodiment of fig. 1-1. The power supply V corresponds to a portion enclosed by a dotted line in fig. 3, an output of the power supply V is an output of the signal distribution circuit 305, one end of the output is connected to the first resistor R11 and the first capacitor C11 which are connected in series, and the other end of the output is connected to the second resistor R12 and the second capacitor C12 which are connected in series; after the third resistor R0 and the third capacitor C0 are connected in parallel, two ends of the third resistor R0 and two ends of the third capacitor C0 are respectively connected with the first capacitor C11 and the second capacitor C12; the first capacitor C11 or the second capacitor C12 is equivalent to a capacitor formed by the copper-clad circuit layer 10, the first insulating layer 20 and the metal substrate 30 in fig. 1; the first resistor R11 is equivalent to a first electrode impedance, the first capacitor C11 is equivalent to a first electrode equivalent capacitor, the second resistor R12 is equivalent to a second electrode impedance, the second capacitor C12 is equivalent to a second electrode equivalent capacitor, the third resistor R0 and the parallel third capacitor C0 are equivalent to a human body model together, an RC charge-discharge loop is integrally formed, a high-frequency signal generated by the output of the power supply V (namely the output of the signal distribution circuit 305) applies an electric field to a human body in a capacitive mode (repeated charge-discharge), and the electric field achieves the effect of inhibiting the proliferation of tumor cells by interfering the mitosis process of the tumor cells.
Referring to fig. 8, fig. 8 is an equivalent circuit diagram of a tumor electric field treatment system according to an embodiment of the invention. Which is suitable for use in the metal substrate electrode of the embodiment of fig. 1-2. The power supply V corresponds to a portion enclosed by a dashed line in fig. 3, an output of the power supply V is an output of the signal distribution circuit 305, one end of the output of the power supply V is connected to the first resistor R11, the first capacitor C11, and the fourth capacitor C21 which are connected in series, and the other end of the output of the power supply V is connected to the second resistor R12, the second capacitor C12, and the fifth capacitor C22 which are connected in series; the first capacitor C11 or the second capacitor C12 is equivalent to the capacitor formed by the copper-clad circuit layer 10, the first insulating layer 20 and the metal substrate 30 in fig. 2; the fourth capacitor C21 or the fifth capacitor C22 is equivalent to the capacitor formed by the metal substrate 30, the second insulating layer 2 and the conductive layer 3 in fig. 2; after the third resistor R0 and the third capacitor C0 are connected in parallel, two ends of the third resistor R0 and two ends of the third capacitor C0 are respectively connected with the fourth capacitor C21 and the fifth capacitor C22; the first resistor R11 is equivalent to a first electrode impedance, the first capacitor C11 and the fourth capacitor C21 which are connected in series are equivalent to a first electrode equivalent capacitor, the second resistor R12 is equivalent to a second electrode impedance, the second capacitor C12 and the fifth capacitor C22 which are connected in series are equivalent to a second electrode equivalent capacitor, the third resistor R0 and the third capacitor C0 which are connected in parallel are equivalent to a human body model, and the whole body forms an RC charge-discharge loop, a high-frequency signal generated by the output of the power supply V (namely the output of the signal distribution circuit 305) applies an electric field to the human body in a capacitive mode (repeated charge-discharge), and the electric field can achieve the effect of inhibiting the proliferation of tumor cells by interfering the mitosis process of the tumor cells.
The above examples only show some embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, many variations and modifications can be made without departing from the spirit of the invention, which falls within the scope of the invention. Therefore, the protection scope of the present invention should be subject to the claims.
Claims (15)
1. The utility model provides a metal substrate electrode, its characterized in that is including covering copper circuit layer, locating cover the first insulation layer of copper circuit layer lower extreme, locate the metal substrate of first insulation layer lower extreme cover the copper circuit layer and have first, second, third and cover copper circuit layer, first cover copper circuit layer is used for connecting the electrode, second, third cover copper circuit layer are used for connecting temperature sensor, it is equipped with and hinders the solder film layer to cover copper circuit layer top.
2. The metal substrate electrode of claim 1, further comprising a second insulating layer underlying the metal substrate and a conductive layer underlying the second insulating layer.
3. The metal substrate electrode according to claim 1 or 2, wherein the metal substrate electrode is in contact with the skin through a conductive gel.
4. The metal substrate electrode according to claim 3, wherein the thickness of the conductive gel is 0.1-5mm.
5. The metal substrate electrode as claimed in claim 1, wherein the copper-clad circuit layer has a terminal at the end thereof, and the electrode wire and the temperature sensor are connected to the copper-clad circuit layer through the terminal.
6. The metal substrate electrode as claimed in claim 5, wherein the terminal and the periphery of the solder resist film layer are provided with an insulating potting layer.
7. The metal substrate electrode according to claim 5, wherein the connection terminal is a pad or a socket.
8. The metal substrate electrode according to claim 1, wherein the metal substrate electrode surface is provided with a gas permeable adhesive tape.
9. The metal-substrate electrode according to claim 1, wherein the area of the lower surface of the metal-substrate electrode is not more than 50cm 2 。
10. The metal substrate electrode as claimed in claim 1, wherein the first insulating layer comprises epoxy glue and ceramic powder, and the mass ratio of the epoxy glue to the ceramic powder is 1.
11. The metal substrate electrode according to claim 1, wherein the metal substrate is one of an aluminum substrate, a copper substrate, and an iron substrate.
12. An electric field treatment electrode for tumor, wherein at least two metal substrate electrodes according to any one of claims 1 to 11 respectively form a first electrode and a second electrode, the first electrode and the second electrode form a pair of electrodes, the first electrode is connected with a first electrode wire, and the second electrode is connected with a second electrode wire.
13. A tumor electric field treatment system, comprising a human-computer interface, a control unit, a power supply unit, a voltage amplitude adjusting circuit, an inverse frequency modulation circuit and a signal distribution circuit, and further comprising the tumor electric field treatment electrode of claim 12.
14. The electric field tumor therapy system according to claim 13, wherein said electric field tumor therapy electrodes are plural, and said signal distribution circuit time-divisionally distributes said plural electric field tumor therapy electrodes;
the temperature sensor on the tumor electric field treatment electrode is connected with the control unit;
the control unit is used for controlling the power supply unit, the voltage amplitude regulating circuit, the inverse frequency modulation circuit, the signal distribution circuit and the tumor electric field treatment electrode;
the power supply unit is used for supplying power to the tumor electric field treatment system;
the voltage amplitude regulating circuit, the inverter frequency modulation circuit and the signal distribution circuit are sequentially connected in series;
the tumor electric field treatment system sets control parameters through a human-computer interaction interface, and the control unit controls and modulates the output voltage of the power supply unit, the output voltage of the voltage amplitude regulating circuit, the output frequency of the inverter frequency modulation circuit and the scanning period of the signal distribution circuit to enable the output voltage, the output frequency and the scanning period of the inverter frequency modulation circuit to reach the control parameters, and monitors, early warns and protects the temperature of the tumor electric field treatment electrode.
15. The electric field tumor therapy system according to claim 13, wherein the first electrode and the second electrode respectively comprise a plurality of metal substrate electrodes of the same number, the plurality of metal substrate electrodes are arranged in an array, and two adjacent metal substrate electrodes are connected to each other.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310284480.8A CN115970155B (en) | 2023-03-22 | 2023-03-22 | Metal substrate electrode, tumor electric field treatment electrode and system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310284480.8A CN115970155B (en) | 2023-03-22 | 2023-03-22 | Metal substrate electrode, tumor electric field treatment electrode and system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115970155A true CN115970155A (en) | 2023-04-18 |
| CN115970155B CN115970155B (en) | 2023-08-22 |
Family
ID=85958309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310284480.8A Active CN115970155B (en) | 2023-03-22 | 2023-03-22 | Metal substrate electrode, tumor electric field treatment electrode and system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115970155B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117180617A (en) * | 2023-10-09 | 2023-12-08 | 深圳奥派森生物电磁科技有限公司 | Electrode and system for electric field therapy |
Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1703258A (en) * | 2002-10-02 | 2005-11-30 | 斯坦顿有限公司 | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| CN102610545A (en) * | 2012-03-02 | 2012-07-25 | 迅力光能（昆山）有限公司 | Short circuit defect passivation method and device for thin film photoelectronic device |
| CN106823145A (en) * | 2017-03-24 | 2017-06-13 | 长沙普特斯科技有限公司 | A kind of device of use amplitude modulation electric field treatment tumour |
| US20200269043A1 (en) * | 2019-02-27 | 2020-08-27 | Novocure Gmbh | Delivering Tumor Treating Fields (TTFields) Using Implantable Transducer Arrays |
| CN112501015A (en) * | 2020-12-23 | 2021-03-16 | 深圳奥派森生物电磁科技有限公司 | Device for inhibiting or destroying tumor cell division |
| CN112755385A (en) * | 2021-01-26 | 2021-05-07 | 江苏海莱新创医疗科技有限公司 | Electrode for defected skull |
| CN113769274A (en) * | 2021-10-26 | 2021-12-10 | 深圳奥派森生物电磁科技有限公司 | Magnetic field tumor treatment equipment |
| CN113842546A (en) * | 2021-09-13 | 2021-12-28 | 重庆极治医疗科技有限公司 | Electrode array for treating tumor |
| US20210402179A1 (en) * | 2020-06-30 | 2021-12-30 | Novocure Gmbh | Flexible Transducer Arrays with a Polymer Insulating Layer for Applying Tumor Treating Fields (TTFields) |
| CN113856052A (en) * | 2021-09-28 | 2021-12-31 | 江苏海莱新创医疗科技有限公司 | Active heat absorption type electrode, tumor electric field treatment system and temperature control method |
| CN114099959A (en) * | 2021-12-22 | 2022-03-01 | 江苏海莱新创医疗科技有限公司 | Tumor electric field treatment system and electrode patch thereof |
| CN114247051A (en) * | 2021-12-22 | 2022-03-29 | 江苏海莱新创医疗科技有限公司 | Tumor electric field treatment system and electrode patch thereof |
| TW202211947A (en) * | 2020-09-25 | 2022-04-01 | 瑞士商諾沃庫勒有限責任公司 | Varying the metallization area on individual electrode elements in a tumor treating fields (ttfields) system to maximize current without overheating |
| WO2022123455A1 (en) * | 2020-12-09 | 2022-06-16 | Lifebridge Innovations, Pbc | Insulated electrode for delivering tumor treating electromagnetic fields |
| CN217719126U (en) * | 2022-06-24 | 2022-11-01 | 浙江大学医学院附属第一医院 | Single-needle type pulsed electric field ablation electrode capable of cooling by water cooling |
| CN115300790A (en) * | 2022-08-12 | 2022-11-08 | 青岛市中医医院(青岛市海慈医院、青岛市康复医学研究所) | Electrode slice of electrode treatment equipment for tumor electric field treatment |
-
2023
- 2023-03-22 CN CN202310284480.8A patent/CN115970155B/en active Active
Patent Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1703258A (en) * | 2002-10-02 | 2005-11-30 | 斯坦顿有限公司 | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| CN102610545A (en) * | 2012-03-02 | 2012-07-25 | 迅力光能（昆山）有限公司 | Short circuit defect passivation method and device for thin film photoelectronic device |
| CN106823145A (en) * | 2017-03-24 | 2017-06-13 | 长沙普特斯科技有限公司 | A kind of device of use amplitude modulation electric field treatment tumour |
| US20200269043A1 (en) * | 2019-02-27 | 2020-08-27 | Novocure Gmbh | Delivering Tumor Treating Fields (TTFields) Using Implantable Transducer Arrays |
| US20210402179A1 (en) * | 2020-06-30 | 2021-12-30 | Novocure Gmbh | Flexible Transducer Arrays with a Polymer Insulating Layer for Applying Tumor Treating Fields (TTFields) |
| TW202211947A (en) * | 2020-09-25 | 2022-04-01 | 瑞士商諾沃庫勒有限責任公司 | Varying the metallization area on individual electrode elements in a tumor treating fields (ttfields) system to maximize current without overheating |
| WO2022123455A1 (en) * | 2020-12-09 | 2022-06-16 | Lifebridge Innovations, Pbc | Insulated electrode for delivering tumor treating electromagnetic fields |
| CN112501015A (en) * | 2020-12-23 | 2021-03-16 | 深圳奥派森生物电磁科技有限公司 | Device for inhibiting or destroying tumor cell division |
| CN112755385A (en) * | 2021-01-26 | 2021-05-07 | 江苏海莱新创医疗科技有限公司 | Electrode for defected skull |
| CN113842546A (en) * | 2021-09-13 | 2021-12-28 | 重庆极治医疗科技有限公司 | Electrode array for treating tumor |
| CN113856052A (en) * | 2021-09-28 | 2021-12-31 | 江苏海莱新创医疗科技有限公司 | Active heat absorption type electrode, tumor electric field treatment system and temperature control method |
| CN113769274A (en) * | 2021-10-26 | 2021-12-10 | 深圳奥派森生物电磁科技有限公司 | Magnetic field tumor treatment equipment |
| CN114099959A (en) * | 2021-12-22 | 2022-03-01 | 江苏海莱新创医疗科技有限公司 | Tumor electric field treatment system and electrode patch thereof |
| CN114247051A (en) * | 2021-12-22 | 2022-03-29 | 江苏海莱新创医疗科技有限公司 | Tumor electric field treatment system and electrode patch thereof |
| CN217719126U (en) * | 2022-06-24 | 2022-11-01 | 浙江大学医学院附属第一医院 | Single-needle type pulsed electric field ablation electrode capable of cooling by water cooling |
| CN115300790A (en) * | 2022-08-12 | 2022-11-08 | 青岛市中医医院(青岛市海慈医院、青岛市康复医学研究所) | Electrode slice of electrode treatment equipment for tumor electric field treatment |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117180617A (en) * | 2023-10-09 | 2023-12-08 | 深圳奥派森生物电磁科技有限公司 | Electrode and system for electric field therapy |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115970155B (en) | 2023-08-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20110172750A1 (en) | Methods and apparatus for active patient warming | |
| US10939839B2 (en) | Body worn physiological sensor device having a disposable electrode module | |
| US20090171341A1 (en) | Dispersive return electrode and methods | |
| EP2364747B1 (en) | Electrodes for applying an electric field in-vivo over an extended period of time | |
| CN113453638A (en) | Delivering tumor therapy fields (TTfields) using an implantable transducer array | |
| CN115970155A (en) | Metal substrate electrode, tumor electric field treatment electrode and system | |
| CN116920275A (en) | Tumor electric field treatment system | |
| US20130245727A1 (en) | Systems and methods for thermolipolysis using rf energy | |
| CN110944701A (en) | Powering a respiratory device | |
| BR112016015099B1 (en) | UNIVERSAL SAFETY ELECTROSURGICAL RETURN ELECTRODE | |
| CN115211956A (en) | Radio frequency therapeutic apparatus and control method thereof | |
| CN202960894U (en) | Carbon fiber patient warming system | |
| EP4223364A1 (en) | Varying the metallization area on individual electrode elements in a tumor treating fields (ttfields) system to maximize current without overheating | |
| JPWO2021226353A5 (en) | ||
| Kilgore et al. | Powering strategies for implanted multi‐function neuroprostheses for spinal cord injury | |
| CN112770470A (en) | Dielectric barrier discharge device | |
| CN213345932U (en) | Radio frequency treatment head and treatment device | |
| KR100880213B1 (en) | Apparatus for blocking and displaying a generated microwave in a warm displacement decorated pouf | |
| CN211608297U (en) | Cooling gloves | |
| US20230019638A1 (en) | Using Capacitors to Regulate Current in Transducer Arrays for Applying Tumor Treating Fields (TTFields) | |
| CN110150901A (en) | Energy-saving heating mattress | |
| CN208212129U (en) | A kind of medical nursing antibacterial pad | |
| CN218391872U (en) | Cell division suppression device | |
| WO2023116659A1 (en) | Tumor electric field treatment system and insulation electrode thereof | |
| CN219921857U (en) | Tumor electric field treatment system and electrode slice thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |