CN113054960A - Electric signal output device, system, output method, and storage medium - Google Patents
Electric signal output device, system, output method, and storage medium Download PDFInfo
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- CN113054960A CN113054960A CN202110335884.6A CN202110335884A CN113054960A CN 113054960 A CN113054960 A CN 113054960A CN 202110335884 A CN202110335884 A CN 202110335884A CN 113054960 A CN113054960 A CN 113054960A
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- electrical signal
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- biological tissue
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- H—ELECTRICITY
- H03—ELECTRONIC CIRCUITRY
- H03K—PULSE TECHNIQUE
- H03K17/00—Electronic switching or gating, i.e. not by contact-making and –breaking
- H03K17/08—Modifications for protecting switching circuit against overcurrent or overvoltage
- H03K17/082—Modifications for protecting switching circuit against overcurrent or overvoltage by feedback from the output to the control circuit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
Abstract
The embodiment of the application provides electric signal output equipment, an electric signal output system, an electric signal output method and a storage medium. The electric signal output device includes: a control unit and an electrical signal generator; the input end of the electric signal generator is electrically connected with a power supply, and the output end of the electric signal generator is electrically connected with the target biological tissue; and the control unit is electrically connected with the control end of each switching device of the electric signal generator and is used for controlling the conduction frequency of each switching device so as to output the electric signal within the designed frequency range to the target biological tissue. The control unit of this application embodiment is through the conduction frequency of each switching device of control signal generator, to the signal of telecommunication of target biological tissue output design frequency range, and the signal of telecommunication in the design frequency range can let more cells receive the effective effect of signal of telecommunication to can improve the electricity elimination effect.
Description
Technical Field
The present application relates to the field of medical device technologies, and in particular, to an electrical signal output device, an electrical signal output system, an electrical signal output method, and a storage medium.
Background
The electric elimination of tumor mainly includes operation, radiotherapy and chemotherapy, but all have corresponding disadvantages, for example, radiotherapy and chemotherapy can produce side effects and kill normal cells. The electrical ablation of tumors by electric field is also one of the current developments.
In the existing mode of adopting electric field tumor electricity to eliminate, the electric field only has effective effect on a few cells, which results in poor treatment effect.
Disclosure of Invention
The application aims at the defects of the prior art and provides an electric signal output device, an electric signal output system, an electric signal output method and a storage medium, which are used for solving the technical problem that the treatment effect is poor due to the fact that an electric field only has an effective effect on a few cells in the prior art.
In a first aspect, an embodiment of the present application provides an electrical signal output apparatus, including: a control unit and an electrical signal generator;
the input end of the electric signal generator is electrically connected with a power supply, and the output end of the electric signal generator is electrically connected with the target biological tissue;
and the control unit is electrically connected with the control end of each switching device of the electric signal generator and is used for controlling the conduction frequency of each switching device so as to output the electric signal within the designed frequency range to the target biological tissue.
In one possible implementation, the designed frequency range of the electrical signal is 50 kHz-500 kHz.
In one possible implementation, the electrical signal generator comprises a single-phase full-bridge inverter circuit.
In a second aspect, an embodiment of the present application provides an electrical signal output system, including: an electric signal output device and a power supply as in the first aspect;
the power supply is electrically connected with the electric signal generator.
In one possible implementation, the electrical signal output system further includes: at least one electrode;
the input end of the electrode is electrically connected with the electric signal generator, and the output end of the electrode is used for being electrically connected with the target biological tissue and outputting the electric signal within the designed frequency range to the target biological tissue.
In one possible implementation, the arrangement state of at least one electrode at the target biological tissue matches the design frequency range;
and/or the power supply is a direct current power supply with adjustable voltage.
In one possible implementation manner, the electric signal output system further comprises an upper computer;
and the upper computer is in communication connection with a control unit in the electric signal output equipment.
In a third aspect, an embodiment of the present application provides an electrical signal output method, including:
the conduction frequency of each switching device of the electrical signal generator is controlled to output an electrical signal within a designed frequency range to the target biological tissue.
In one possible implementation, controlling the conduction frequency of each switching device of the electrical signal generator to output an electrical signal within a designed frequency range to a target biological tissue includes:
the conduction frequency of each switching device of the electrical signal generator is controlled to output a variable frequency sinusoidal pulse signal within a designed frequency range to the target biological tissue.
In one possible implementation, the electrical signal output method further includes:
controlling the power supply to output a design voltage and controlling the electric signal generator to be electrically connected with the power supply;
controlling the turn-on frequency of each switching device of the electrical signal generator to output an electrical signal within a designed frequency range to a target biological tissue, comprising:
according to the design voltage, the conduction frequency of each switching device of the electric signal generator is controlled to output an electric signal in a design frequency range matching the design voltage to the target biological tissue.
In a fourth aspect, an embodiment of the present application provides an electrical signal output apparatus, including:
and the first control module is used for controlling the conduction frequency of each switching element of the electric signal generator so as to output the electric signal within the designed frequency range to the target biological tissue.
In a fifth aspect, embodiments of the present application provide a computer-readable storage medium on which a computer program is stored, the computer program, when executed by an electrical signal output apparatus, implementing the electrical signal output method of the third aspect.
The beneficial technical effects brought by the technical scheme provided by the embodiment of the application comprise:
the control unit of the electric signal output equipment of the embodiment of the application is electrically connected with the control end of each switching device of the electric signal generator, the control unit outputs the electric signal in the designed frequency range to the target biological tissue by controlling the conduction frequency of each switching device, and the electric signal in the designed frequency range of the embodiment of the application can enable more cells to receive the effective action of the electric signal, so that the electric eliminating effect of tumors is greatly improved.
Additional aspects and advantages of the present application will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the present application.
Drawings
The foregoing and/or additional aspects and advantages of the present application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
fig. 1 is a schematic structural diagram of an electrical signal output device according to an embodiment of the present disclosure;
fig. 2 is a schematic structural diagram of an electrical signal output system according to an embodiment of the present disclosure;
fig. 3 is a schematic circuit diagram of an electrical signal output system according to an embodiment of the present application;
FIG. 4 is a schematic structural diagram of another electrical signal output system provided in an embodiment of the present application;
fig. 5 is a schematic circuit diagram of a single-phase full-bridge inverter circuit of an electrical signal output system according to an embodiment of the present disclosure;
fig. 6 is a schematic structural diagram of an electrical signal output device according to an embodiment of the present application.
Reference numerals:
100-an electrical signal output device;
110-control unit, 111-switch control circuit;
120-electrical signal generator, 121-inverter circuit;
200-power supply, 210-direct current power supply;
300-electrodes;
400-PWM output end;
500-load;
600-an upper computer;
60-an electrical signal output device;
610-first control module.
Detailed Description
Reference will now be made in detail to the present application, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar parts or parts having the same or similar functions throughout. In addition, if a detailed description of the known art is not necessary for illustrating the features of the present application, it is omitted. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present application and are not to be construed as limiting the present application.
It will be understood by those within the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. It will be understood that when an element is referred to as being "connected" or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may also be present. Further, "connected" or "coupled" as used herein may include wirelessly connected or wirelessly coupled. As used herein, the term "and/or" includes all or any element and all combinations of one or more of the associated listed items.
The inventors of the present application have conducted studies to find that the electric field that can be used in medical applications can be generally divided into two different modes. In the first mode, an electric field is applied to the body or tissue through the conductive electrode. These electric fields can be divided into two types, namely a steady electric field or an electric field that varies at a relatively low rate, and a low-frequency electric signal that induces a corresponding current in the body or tissue, and a high-frequency electric signal (above 1 MHz) that is applied to the body through conductive electrodes. In the second mode, the electric field is a high frequency electrical signal applied to the body through insulated electrodes.
The first mode of electric field is used to stimulate nerves and muscles, adjust the heart rate (pacete heart), and the like. Indeed, in nerve and muscle fibers, the Central Nervous System (CNS), the heart, etc., such electric fields are essentially used to conduct signals. The electric field strength in these applications is assumed to be a medium with uniform electrical properties, i.e., the voltage applied to the stimulating/recording electrode divided by the distance between the two. These currents can be calculated by Ohm's law, which can have dangerous stimulatory effects on the heart and CNS and can lead to potentially harmful ion concentration changes. Moreover, if the currents are strong enough, they can cause excessive heating in the tissue. The application of such electric field-inducing currents can cause associated deleterious side effects if the frequency is not considered.
The electric field of the second mode generally adopts a single frequency, and the electric field under the single frequency only has effective effect on a few cells because of obvious tumor cell difference, so that the good electric elimination effect cannot be achieved.
The application provides an electrical signal output device, a system, an output method and a storage medium, which aim to solve the technical problems in the prior art.
The following describes the technical solutions of the present application and how to solve the above technical problems with specific embodiments.
An embodiment of the present application provides an electrical signal output apparatus 100, shown in fig. 1, including: a control unit 110 and an electrical signal generator 120.
The input of the electrical signal generator 120 is adapted to be electrically connected to the power source 200, and the output of the electrical signal generator 120 is adapted to be electrically connected to the target biological tissue.
The control unit 110 is electrically connected to the control terminal of each switching device of the electrical signal generator 120, and is configured to control the conducting frequency of each switching device so as to output an electrical signal within a designed frequency range to the target biological tissue.
The control unit 110 of the embodiment of the present application is electrically connected to the control terminals of the switching devices of the electrical signal generator 120, and the control unit 110 outputs the electrical signal within the designed frequency range to the target biological tissue by controlling the conduction frequency of the switching devices.
Meanwhile, the electric signal in the designed frequency range of the embodiment of the application has a sufficient electric ablation effect on the cells, the electric ablation effect of the electric signal with other frequencies is limited, and the efficiency of the electric ablation on the cells in the designed frequency range of the embodiment of the application is higher.
The electrical signal generator 120 of the embodiment of the application can flexibly output electrical signals with any frequency combination in a designed frequency range under the control of the control unit 110, can replace a plurality of electrical signal generating devices with different frequencies, and reduces the complexity of operation and maintenance and the cost.
Optionally, the electrical signal comprises an alternating electric field or a pulsed signal. The pulse signal comprises a sinusoidal pulse signal with a variable frequency.
Alternatively, the variable frequency sinusoidal pulse signal comprises a continuously variable frequency sinusoidal pulse signal.
Optionally, the target biological tissue comprises a human body part.
The embodiment of the application controls the on-off frequency of each switching element of the electric signal generator 120 based on the designed frequency range, realizes the continuous frequency conversion of the electric field for eliminating tumor electricity, ensures that tumor cells are influenced by the effective electric field, and enlarges the electric eliminating effect of tumors.
Optionally, the designed frequency range of the electrical signal is 50 khz-500 khz.
Alternatively, the designed frequency range of the electrical signal is 100 kHz-300 kHz.
Optionally, the designed frequency range of the electrical signal is 170 khz-250 khz.
Optionally, the alternating electric field has a field strength in a range of 0.1 volts per centimeter to 10 volts per centimeter.
Optionally, the alternating electric field has a field strength in a range of 1 volt per centimeter to 5 volts per centimeter.
In some embodiments, referring to fig. 3, the electrical signal generator 120 includes an inverter circuit 121, and the inverter circuit 121 includes a single-phase full-bridge inverter circuit.
Alternatively, the single-phase full-bridge inverter circuit may convert the direct current into alternating current, forming an electrical signal acting on the target biological tissue.
The electric signal output apparatus 100 of the embodiment of the present application can be applied to organisms having cells that proliferate, divide and multiply, which require selective destruction, such as tissue cultures, in addition to electrically eliminating tumors in the human body. Such as microorganisms like bacteria, mycoplasma, protozoa, etc., fungi, algae, plant cells, etc. Such organisms divide by forming the furrows and crevices described above. As the groove or cleft deepens, a narrow bridge is formed between the two parts of the organism, similar to the bridge formed between subcellular cells of dividing animal cells. Since such organisms are coated with a membrane having a relatively low conductivity, similar to the animal cell membranes described above, the electric field lines in the dividing organism converge at the bridge connecting the two parts of the dividing organism, the converging field lines generating electricity that moves the polarizable members and charges within the dividing organism.
Alternatively, the electrical signal output apparatus 100 may further include: a memory. The control unit 110 and the memory are electrically connected, such as by a bus. Alternatively, the control Unit 110 may be a CPU (Central Processing Unit), a general-purpose Processor, a DSP (Digital Signal Processor), an ASIC (Application Specific Integrated Circuit), an FPGA (Field-Programmable Gate Array) or other Programmable logic device, a transistor logic device, a hardware component, or any combination thereof. Which may implement or perform the various illustrative logical blocks, modules, and circuits described in connection with the disclosure. The control unit 110 may also be a combination of implementing computing functions, e.g., comprising one or more microprocessors, a combination of DSPs and microprocessors, or the like.
Alternatively, the bus may include a path that carries information between the aforementioned components. The bus may be a PCI (Peripheral Component Interconnect) bus, an EISA (Extended Industry Standard Architecture) bus, or the like. The bus may be divided into an address bus, a data bus, a control bus, etc.
Alternatively, the Memory may be, but is not limited to, a ROM (Read-Only Memory) or other type of static storage device that can store static information and instructions, a RAM (random access Memory) or other type of dynamic storage device that can store information and instructions, an EEPROM (Electrically Erasable Programmable Read Only Memory), a CD-ROM (Compact Disc Read-Only Memory) or other optical Disc storage, optical Disc storage (including Compact Disc, laser Disc, optical Disc, digital versatile Disc, blu-ray Disc, etc.), a magnetic disk storage medium or other magnetic storage device, or any other medium that can be used to carry or store desired program code in the form of instructions or data structures and that can be accessed by a computer.
In some possible embodiments, the electrical signal output device 100 may further include a monitoring unit. The monitoring unit may be used to monitor the current and/or voltage parameters of the electrode 300, and the control unit 110 determines the working state of the electrode 300 by the current and/or voltage parameters of the electrode 300 obtained by the monitoring unit. For example, if the current and/or voltage parameters of the electrode 300 obtained by the monitoring unit correspond to the current and/or voltage of the electrode 300 when it is empty (not connected to a load), it is determined that the electrode 300 has currently outputted the sequence of electrical pulses.
In some possible embodiments, the electrical signal output device 100 may further include a transceiver. The transceiver may be used for reception and transmission of signals. The transceiver may allow the control unit 110 of the electrical signal output device 100 to communicate with other devices wirelessly or by wire to exchange data, for example, when the control unit 110 receives an ablation stop command or a needle withdrawing command input by a user through the transceiver, the control unit 110 is triggered to control the pulse generator 112 to start the output electrical pulse sequence or control the pulse generator 112 to stop the output electrical pulse sequence. It should be noted that the number of the transceivers in practical application is not limited to one.
In some possible embodiments, the electrical signal output apparatus 100 may further include an input unit. The input unit may be used to receive input numeric, character, image and/or sound information or to generate key signal inputs related to user settings and function control of the control unit 110. The input unit may include, but is not limited to, one or more of a touch screen, a physical keyboard, function keys (such as volume control keys, switch keys, etc.), a trackball, a mouse, a joystick, a camera, a microphone, and the like.
In some possible embodiments, the electrical signal output apparatus 100 may further include an output unit. The output unit may be used to output or present information processed by the control unit 110. The output unit may include, but is not limited to, one or more of a display device, a speaker, a vibration device, and the like.
It will be understood by those skilled in the art that the control unit 110 of the electrical signal output apparatus 100 provided in the embodiments of the present application may be specially designed and manufactured for the required purposes, or may also include a known device in a general-purpose computer. These devices have stored therein computer programs that are selectively activated or reconfigured. Such a computer program may be stored in a device (e.g., computer) readable medium or in any type of medium suitable for storing electronic instructions and respectively coupled to a bus.
Based on the same inventive concept, an embodiment of the present application provides an electrical signal output system, as shown in fig. 2, including: an electrical signal output device 100 and a power supply 200 of any embodiment of the present application.
The power supply 200 is electrically connected to the electrical signal generator 120.
In some embodiments, referring to fig. 2, the electrical signal output system further comprises: at least one electrode 300.
The electrode 300 has an input electrically connected to the electrical signal generator 120 and an output for electrically connecting to the target biological tissue to output an electrical signal within a designed frequency range to the target biological tissue.
In some embodiments, the arrangement state of the at least one electrode 300 at the target biological tissue matches the design frequency range.
Alternatively, the arrangement state of the electrode 300 at the target biological tissue may be matched according to both parameters of the voltage amplitude and the design frequency range.
Alternatively, as an example, referring to fig. 3, the power supply 200 is a voltage-adjustable dc power supply 210, the control unit 110 includes a switch control circuit 111, the switch control circuit 111 is electrically connected to the inverter circuit 121, the switch control circuit 111 controls on and off of each switching device of the inverter circuit 121, an output terminal of the inverter circuit 121 is electrically connected to a PWM (Pulse Width Modulation) output terminal 400, the PWM output terminal 400 is electrically connected to a load 500 through an electrode 300, and the load 500 is a target biological tissue, so that an electrical signal in a designed frequency range is output to the target biological tissue.
Optionally, the dc power supply 210 is configured to adjust a voltage amplitude of the sinusoidal pulse signal, and the voltage amplitude of the sinusoidal pulse signal is correspondingly adjusted by adjusting the voltage of the dc power supply 210.
Alternatively, the dc power supply 210 employs a rechargeable lithium battery product.
Alternatively, the design frequency range is set according to clinical trials and the actual condition of the target biological tissue.
Alternatively, the respective power supply 200 voltages, design frequency ranges, and arrangement states of the electrodes 300 are selected according to the target biological tissue, such as a tumor, for different sizes, periods, and sites.
Optionally, the voltage amplitude and the sweep frequency range of the output sinusoidal pulse signal may be mutually independent parameters, or parameters that are correspondingly matched in advance according to actual working experience, and are both independently adjustable, and combined parameters of different schemes may be designed for different electrical cancellation effects.
Optionally, the output sinusoidal pulse signal is full sinusoidal alternating current with adjustable amplitude frequency, and the waveform of the electric eliminating electric field can be low-intensity (1V-3V) sinusoidal alternating current.
In some embodiments, referring to fig. 4, the electrical signal output system further comprises an upper computer 600.
The upper computer 600 is in communication connection with the control unit 110 in the electrical signal output device 100.
In this embodiment, the upper computer 600 may update a program or backup data of the control unit 110 in the electrical signal output device 100, and may also implement remote control of the electrical signal output device 100, thereby facilitating function expansion of the electrical signal output device 100.
Optionally, the upper computer 600 is in communication connection with the control unit 110 in the electrical signal output device 100 through WIFI (Wireless Fidelity).
Optionally, the upper computer 600 is connected to the control unit 110 in the electrical signal output device 100 in a communication manner through a cloud.
Optionally, as an example, referring to fig. 5, a circuit schematic diagram of a single-phase full-bridge inverter circuit is provided, where the switching device VT1 and the switching device VT4 form a pair of bridge arms, and the switching device VT2 and the switching device VT3 form another pair of bridge arms. VD1, VD2, VD3 and VD4 are freewheeling diodes, the voltage Ud is the power supply 200, C is the capacitor, R is the resistor and L is the inductor. The bases of the switch device VT1 and the switch device VT2 are added with a pair of opposite control pulses, the phases of the control pulses of the bases of the switch device VT3 and the switch device VT4 are also opposite, and the phase of the control pulse of the base of the switch device VT3 lags behind the angle of theta of the switch device VT1 (theta is more than or equal to 0 degree and less than or equal to 180 degrees).
Based on the same inventive concept, the embodiment of the application provides an electric signal output method, which comprises the following steps: the turn-on frequency of each switching device of the electrical signal generator 120 is controlled to output an electrical signal within a designed frequency range to the target biological tissue.
The electric signal output method of the embodiment of the application outputs the electric signals within the designed frequency range to the target biological tissue by controlling the conduction frequency of each switching device, and the electric signals within the designed frequency range can enable more cells to be effectively acted by the electric signals, so that the electric elimination effect is greatly improved.
Alternatively, the control unit 110 controls the turn-on frequency of each switching device of the electric signal generator 120 to output an electric signal within a designed frequency range to the target biological tissue.
In some embodiments, controlling the turn-on frequency of each switching device of the electrical signal generator 120 to output an electrical signal in a designed frequency range to the target biological tissue includes:
the turn-on frequency of each switching device of the electrical signal generator 120 is controlled to output a variable frequency sinusoidal pulse signal within a designed frequency range to the target biological tissue.
Alternatively, the control unit 110 controls the turn-on frequency of each switching device of the electric signal generator 120 to output a frequency-variable sinusoidal pulse signal within a designed frequency range to the target biological tissue.
Optionally, controlling the conducting frequency of each switching device of the electrical signal generator 120 to output an electrical signal in a designed frequency range to the target biological tissue includes:
the turn-on frequency of each switching device of the electrical signal generator 120 is controlled to output a pulse train of a first design frequency and a pulse train of a second design frequency to the target biological tissue.
Alternatively, the control unit 110 controls the turn-on frequency of each switching device of the electric signal generator 120 to output the pulse train of the first design frequency and the pulse train of the second design frequency to the target biological tissue.
Optionally, outputting to the target biological tissue a pulse train of a first design frequency and a pulse train of a second design frequency, comprising:
alternately outputting a pulse train of a first design frequency and a pulse train of a second design frequency to the target biological tissue.
Optionally, the first pulse train is a square wave pulse train.
Optionally, the second pulse sequence is a square wave pulse sequence.
Optionally, the first pulse train and the first pulse train are both square wave pulse trains. Each electric pulse in the square wave pulse sequence applies stable electric potential to the target cell, so that the organelles are favorably subjected to constant pulse electric field force, the organelles are favorably drawn towards the equatorial plate, or the cell membranes are favorably hammered by the organelles.
Optionally, alternately outputting a pulse train of a first design frequency and a pulse train of a second design frequency to the target biological tissue, comprising:
after outputting the first pulse signals of the first design number in the pulse sequence of the first design frequency to the target biological tissue, outputting the first pulse signals of the second design number in the pulse sequence of the second design frequency to the target biological tissue.
Optionally, the first design number and the second design number are both integers greater than or equal to 1.
Optionally, each switching device in the embodiments of the present application may be a transistor. The transistors may be Insulated Gate Bipolar Transistors (IGBTs), which are composite fully-controlled voltage-driven power Semiconductor devices composed of BJTs (Bipolar Junction transistors) and MOS (Metal Oxide Semiconductor) transistors, and have the advantages of both high input impedance of MOSFETs (Metal-Oxide-Semiconductor Field Effect transistors) and low on-state voltage drop of GTRs (Giant transistors, high power transistors).
In some embodiments, the electrical signal output method further includes:
the control power supply 200 outputs a design voltage, and the control electric signal generator 120 is electrically connected to the power supply 200 outputting the design voltage.
Controlling the turn-on frequency of each switching device of the electrical signal generator 120 to output an electrical signal within a designed frequency range to the target biological tissue, includes:
according to the design voltage, the turn-on frequency of each switching device of the electric signal generator 120 is controlled to output an electric signal in a design frequency range matching the design voltage to the target biological tissue.
Alternatively, the control unit 110 controls the power supply 200 to output the design voltage, and controls the electrical signal generator 120 to be electrically connected to the power supply 200 outputting the design voltage.
Alternatively, the control unit 110 controls the turn-on frequency of each switching device of the electric signal generator 120 according to the design voltage to output the electric signal in the design frequency range matching the design voltage to the target biological tissue.
Based on the same inventive concept and with reference to fig. 1 to 3 of the present application, an embodiment of the present application further provides an electrical signal output method, including the following steps:
the method comprises the following steps: the control unit 110 controls the power supply 200 to output the design voltage, and controls the electrical signal generator 120 to be electrically connected to the output design voltage power supply 200.
Step two: the control unit 110 controls the turn-on frequency of each switching device of the electric signal generator 120.
Step three: the electric signal generator 120 outputs a sinusoidal pulse signal with a variable frequency within a designed frequency range to the target biological tissue through each electrode 300.
Based on the same inventive concept, the present embodiment provides an electrical signal output apparatus 50, as shown in fig. 6, the electrical signal output apparatus 60 including: a first control module 610.
The first control module 610 is used for controlling the conducting frequency of each switching device of the electrical signal generator 120 to output the electrical signal within the designed frequency range to the target biological tissue.
Optionally, the first control module 610 is further configured to control the conducting frequency of each switching device of the electrical signal generator 120 to output a variable-frequency sinusoidal pulse signal within a designed frequency range to the target biological tissue.
Optionally, the first control module 610 is further configured to control the power supply 200 to output the design voltage, and control the electrical signal generator 120 to be electrically connected to the power supply 200 outputting the design voltage.
Optionally, the first control module 610 is further configured to control the conducting frequency of each switching device of the electrical signal generator 120 according to the design voltage, so as to output the electrical signal in the design frequency range matching the design voltage to the target biological tissue.
Optionally, the first control module 610 is further configured to control the conduction frequency of each switching device of the electrical signal generator 120 to output the pulse train of the first design frequency and the pulse train of the second design frequency to the target biological tissue.
Based on the same inventive concept, embodiments of the present application provide a computer-readable storage medium on which a computer program is stored, the computer program implementing an electrical signal output method of any embodiment of the present application when executed by an electrical signal output apparatus 100.
The computer readable medium of the present application may be a computer readable signal medium or a computer readable storage medium or any combination of the two. A computer readable storage medium may be, for example, but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the foregoing. More specific examples of the computer readable storage medium may include, but are not limited to: an electrical connection having one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.
In the present application, a computer readable storage medium may be any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device. In this application, however, a computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated data signal may take many forms, including, but not limited to, electro-magnetic, optical, or any suitable combination thereof. A computer readable signal medium may also be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to: electrical wires, optical cables, RF (radio frequency), etc., or any suitable combination of the foregoing.
The computer-readable medium of the embodiments of the present application may be embodied in an electronic device; or may be present alone without being incorporated into the electronic device.
Alternatively, a computer-readable medium of an embodiment of the present application carries one or more programs, which, when executed by the electronic device, cause the electronic device to: receiving a node evaluation request comprising at least two internet protocol addresses; selecting an internet protocol address from at least two internet protocol addresses; returning the selected internet protocol address; wherein the received internet protocol address indicates an edge node in the content distribution network. Computer program code for carrying out operations for embodiments of the present application may be written in any combination of one or more programming languages, including but not limited to an object oriented programming language such as Java, Smalltalk, C + +, and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any type of network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet service provider).
The flowchart and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present application. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s). It should also be noted that, in some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems which perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.
In the context of embodiments of the present application, a machine-readable medium may be a tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device. The machine-readable medium may be a machine-readable signal medium or a machine-readable storage medium. A machine-readable medium may include, but is not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any suitable combination of the foregoing. More specific examples of a machine-readable storage medium would include an electrical connection based on one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.
By applying the embodiment of the application, at least the following beneficial effects can be realized:
(1) the electric signal within the designed frequency range can be output to the target biological tissue, and the electric signal within the designed frequency range can enable more cells to receive the effective action of the electric signal, so that the electric elimination effect can be improved.
(2) The embodiment of the application controls the on-off frequency of each switching element of the electric signal generator 120 based on the designed frequency range, so that the frequency of the electric field for eliminating tumor electricity is continuously changed, tumor cells can be influenced by the effective electric field, and the electricity elimination effect is enlarged.
(3) The sine pulse signal with the variable switching frequency is output by controlling the switching-on and switching-off frequency of each switching element of the electric signal generator 120, so that the tumor cells can be further ensured to be under the action of an effective electric field, and the electric elimination effect is further improved.
(4) The voltage of the dc power supply 210 connected to the electrical signal generator 120 of the embodiment of the present application is adjustable, so that the voltage amplitude of the sinusoidal pulse signal can be adjusted, and the output of the designed voltage amplitude and the designed frequency range of the sinusoidal pulse signal is realized.
(5) According to the embodiment of the application, the voltage of the corresponding power supply 200, the design frequency range and the arrangement state of each electrode 300 can be selected according to target biological tissues, such as tumors, with different sizes, periods and parts, so that the electric elimination effect is guaranteed.
(7) The embodiment of the application adopts the direct current power supply 210, the switch control circuit 111, the inverter circuit 121 and the PWM output end 400 to form an output circuit to output a sine pulse signal with variable frequency to the load 500 (namely, the target biological tissue), and the whole electric signal output system has the advantages of simple structure, convenient operation and lower cost.
(8) The electric signal output device 100 of the embodiment of the present application can be applied to not only electrically eliminating tumors in a human body but also organisms having cells that proliferate, divide and multiply that need to be selectively destroyed, and is widely used.
Those of skill in the art will appreciate that the various operations, methods, steps in the processes, acts, or solutions discussed in this application can be interchanged, modified, combined, or eliminated. Further, other steps, measures, or schemes in various operations, methods, or flows that have been discussed in this application can be alternated, altered, rearranged, broken down, combined, or deleted. Further, steps, measures, schemes in the prior art having various operations, methods, procedures disclosed in the present application may also be alternated, modified, rearranged, decomposed, combined, or deleted.
In the description of the present application, it is to be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the referred device or element must have a particular orientation, be constructed in a particular orientation, and be operated, and thus should not be construed as limiting the present application.
The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless otherwise specified.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.
In the description herein, particular features, structures, materials, or characteristics may be combined in any suitable manner in any one or more embodiments or examples.
It should be understood that, although the steps in the flowcharts of the figures are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and may be performed in other orders unless explicitly stated herein. Moreover, at least a portion of the steps in the flow chart of the figure may include multiple sub-steps or multiple stages, which are not necessarily performed at the same time, but may be performed at different times, which are not necessarily performed in sequence, but may be performed alternately or alternately with other steps or at least a portion of the sub-steps or stages of other steps.
The foregoing is only a partial embodiment of the present application, and it should be noted that, for those skilled in the art, several modifications and decorations can be made without departing from the principle of the present application, and these modifications and decorations should also be regarded as the protection scope of the present application.
Claims (12)
1. An electric signal output apparatus, characterized by comprising: a control unit and an electrical signal generator;
the input end of the electric signal generator is electrically connected with a power supply, and the output end of the electric signal generator is electrically connected with the target biological tissue;
the control unit is electrically connected with the control end of each switching device of the electric signal generator and is used for controlling the conduction frequency of each switching device so as to output the electric signal within a designed frequency range to the target biological tissue.
2. The electrical signal output device of claim 1, wherein the electrical signal has a design frequency in a range of 50 khz to 500 khz.
3. The electrical signal output device of claim 1, wherein the electrical signal generator comprises a single-phase full-bridge inverter circuit.
4. An electrical signal output system, comprising: an electrical signal output device and power supply according to any one of claims 1 to 3;
the power source is electrically connected with the electrical signal generator.
5. The electrical signal output system of claim 4, further comprising: at least one electrode;
the input end of the electrode is electrically connected with the electric signal generator, and the output end of the electrode is electrically connected with the target biological tissue and outputs the electric signal within the designed frequency range to the target biological tissue.
6. The electrical signal output system according to claim 5, wherein a disposition state of the at least one electrode at the target biological tissue matches the design frequency range;
and/or the power supply is a direct current power supply with adjustable voltage.
7. The electrical signal output system of claim 4, further comprising: an upper computer;
and the upper computer is in communication connection with the control unit in the electric signal output equipment.
8. An electric signal output method, comprising:
the conduction frequency of each switching device of the electrical signal generator is controlled to output an electrical signal within a designed frequency range to the target biological tissue.
9. The electrical signal output method according to claim 8, wherein the controlling of the conduction frequency of each switching device of the electrical signal generator to output the electrical signal in the designed frequency range to the target biological tissue comprises:
the conduction frequency of each switching device of the electrical signal generator is controlled to output a variable frequency sinusoidal pulse signal within a designed frequency range to the target biological tissue.
10. The electrical signal output method according to claim 8, further comprising:
controlling the power supply to output the design voltage, and controlling the electric signal generator to be electrically connected with the power supply outputting the design voltage;
the controlling of the turn-on frequency of each switching device of the electric signal generator to output an electric signal within a designed frequency range to a target biological tissue includes:
and controlling the conduction frequency of each switching device of the electric signal generator according to the design voltage so as to output the electric signal in a design frequency range matched with the design voltage to the target biological tissue.
11. An electric signal output device, comprising:
and the first control module is used for controlling the conduction frequency of each switching element of the electric signal generator so as to output the electric signal within the designed frequency range to the target biological tissue.
12. A computer-readable storage medium on which a computer program is stored, characterized in that the computer program realizes the electric signal output method according to any one of claims 8 to 10 when executed by an electric signal output apparatus.
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| CN202110335884.6A CN113054960A (en) | 2021-03-29 | 2021-03-29 | Electric signal output device, system, output method, and storage medium |
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