WO2021114219A1

WO2021114219A1 - High-frequency bipolar unrecoverable electroporation system

Info

Publication number: WO2021114219A1
Application number: PCT/CN2019/125104
Authority: WO
Inventors: 张晓辰; 薛志孝; 李红刚
Original assignee: 天津市鹰泰利安康医疗科技有限责任公司
Priority date: 2019-12-13
Filing date: 2019-12-13
Publication date: 2021-06-17

Abstract

A high-frequency bipolar unrecoverable electroporation system. The system comprises an upper layer information management module, a lower computer control module and a bipolar high-voltage pulse discharging circuit, wherein the upper layer information management module receives set working parameters and then transmits same to the lower computer control module, and then generates a control signal and transmits same to the bipolar high-voltage pulse discharging circuit so as to produce a bipolar high-voltage pulse. Compared with a conventional unipolar irreversible electroporation pulse sequence, the high-frequency bipolar unrecoverable electroporation system can better and more uniformly increase the induced transmembrane potential of tightly arrayed cells to a simulation electroporation threshold, such that an ablation region is more uniform. The high-frequency bipolar unrecoverable electroporation system can achieve a better tumor ablation effect and the aim of restraining the growth of tumors, and has better safety and validity.

Description

A high-frequency bipolar unrecoverable electroporation system

Technical field

The invention relates to the technical field of medical equipment and equipment for treating tumors, in particular to a high-frequency bipolar non-recoverable electroporation system.

Background technique

Tumors are a common and frequently-occurring disease, among which malignant tumors are the most serious type of disease that endangers human health. Since the pathogenesis and etiology of malignant tumors are not yet fully understood, fundamental preventive measures are lacking. So far, humans have not been able to cure malignant tumors like other common and frequently-occurring diseases. Due to the refractory nature of malignant tumors, scholars from various countries have used a combination of surgery and radiotherapy and chemotherapy to treat malignant tumors in order to achieve a longer survival time for centuries. However, radiotherapy and chemotherapy have a great impact on human immunity and seriously affect the quality of life.

Irreversible Electroporation (IRE) is an emerging non-thermal ablation technique for tumor treatment. It uses microsecond-level high-voltage discharge pulses to form nano-scale pores in the cell membrane of the affected cell, thereby changing the permeability of the cell membrane, destroying the internal balance of the cell, and leading to cell death. This process is called irreversible electroporation. A typical treatment plan for irreversible electroporation is to deliver a square wave pulse with a voltage of 1500v/cm and a pulse width of 50-100μs between two electrode needles in one direction. The number of pulses is 70-100. During the treatment, the number of electrodes, electrode spacing and electrode exposure length can be adjusted according to the size and shape of the tumor. When using IRE, the most important thing is that while the electric field destroys the cell membrane, it will not cause thermal effects and thus cause tissue damage. Therefore, it has a wide range of clinical applications, especially for lesions near important blood vessels and nerves. Injury and ablation, improve the safety of treatment.

Although IRE has good clinical prospects, the existing irreversible electroporation uses unipolar high-voltage discharge pulses to act on cells. When this technology is used to irreversibly ablate tumor cells in the human body, at the moment of pulse discharge It will cause the patient's muscles to twitch greatly, induce the patient's limbs to move greatly, and seriously affect the fixation of the position of the discharge electrode and the treatment effect. Therefore, the current implementation of such operations requires tracheal intubation, general anesthesia, injection of muscle relaxants, and ventilator assistance to perform such operations. It cannot be performed under local anesthesia as easily as most interventional minimally invasive surgery currently used in clinical practice. However, the operation process is cumbersome and expensive, which increases the complexity and risk of ablation surgery, and may cause some complications, thus limiting the application and promotion of this technology.

Summary of the invention

In order to solve the above-mentioned problems in the existing IRE technology, the present invention provides a high-frequency bipolar non-recoverable electroporation system to realize tumor ablation surgery under the conditions of local anesthesia, no muscle relaxant injection, and mechanical ventilation without a ventilator. Improve the safety and quality of surgery.

The present invention is realized by the following technical solutions:

The invention provides a high-frequency bipolar unrecoverable electroporation system, which includes an upper-level information management module, a lower computer control module and a bipolar high-voltage pulse discharge circuit;

The upper-level information management module receives the set working parameters and transmits them to the lower computer control module;

The lower computer control module generates a control signal according to the working parameters transmitted by the upper-level information management module, and transmits the control signal to the bipolar high-voltage pulse discharge circuit to control the charging of the bipolar high-voltage pulse discharge circuit. Discharge parameters, enabling the bipolar high voltage pulse discharge circuit to generate bipolar high voltage pulses;

The bipolar high-voltage pulse discharge circuit generates positive and negative bipolar high-voltage pulses, which are discharged by electrodes in the circuit, and feedback signals are transmitted back to the upper-level information management module.

Further, the upper-level information management module includes an operation unit, a data processing unit, a display unit, and a transmission unit;

The operating unit provides an interactive way for setting working parameters;

The data processing unit processes the data to obtain a processing result;

The display unit displays the interactive interface and the processing result;

The transmission unit is used to transmit working parameters and/or control signals.

Further, it also includes a compiling unit for providing a programming environment to control the discharge sequence of the system.

Further, the lower computer control module further includes a high-frequency bipolar pulse generation control unit, a timing function control unit, and an acquisition unit;

The high-frequency bipolar pulse generation control unit is used to generate a high-frequency bipolar pulse sequence;

The sequential function control unit is used to control the charge and discharge switches in the charge and discharge circuit;

The collection unit is used to monitor and collect the voltage and/or current during the charging and discharging process.

Further, the charge and discharge parameters include charge voltage, discharge pulse voltage, pulse width, number of pulse groups, and number of pulse groups.

Further, it also includes a power amplifying circuit, which is used to amplify the power of the control signal and transmit it to the bipolar high-voltage pulse discharge circuit.

Further, it also includes a voltage/current detection circuit for detecting system charging voltage feedback signals, high-voltage pulse discharge voltages, and current feedback signals, and at the same time uploading the detection results to the upper-level information management module.

Further, it also includes a photoelectric isolation module, the photoelectric isolation module including a first photoelectric isolation unit and a second photoelectric isolation unit;

The first photoelectric isolation unit performs photoelectric isolation for the control signal;

The second photoelectric isolation unit performs photoelectric isolation for the feedback signal.

Further, it also includes a signal filtering unit, which performs filtering processing on the feedback signal input by the bipolar high-voltage pulse discharge circuit.

Further, the bipolar high-voltage pulse discharge circuit includes a charging power supply, an energy storage capacitor group, a fast electronic switch group, and a discharge electrode;

The energy storage capacitor group is connected to the charging power source through a charging switch, and is connected to the discharging electrode through the fast electronic switch group;

The fast electronic switch group is connected with the discharge electrode through a discharge switch.

Further, the energy storage capacitor group includes one or more large-capacity capacitors and one or more small-capacity capacitors;

The large-capacity capacitor and the small-capacity capacitor are connected in parallel;

The capacity of the large-capacity capacitor is 100uF˜400uF; the capacity of the small-capacity capacitor is 0.1uF˜1uF.

Further, it includes two charging switches KJ1 and KJ2;

After the two resistors R1 and R4 are connected in series, one end is arranged between the two charging switches KJ1 and KJ2, and the other end is grounded;

A first feedback signal point is set between the two resistors, and the generated first feedback signal is fed back to the upper-level information management module.

Further, it includes two of the discharge switches KJ3 and KJ4, each discharge switch is connected to a discharge electrode, and discharges in bipolar alternately;

After the two resistors R2 and R3 are connected in series, one end is connected between the fast electronic switch group and KJ3, and the other end is grounded;

A second feedback signal point is set between the two resistors R2 and R3, and the generated second feedback signal is fed back to the upper-level information management module.

Further, it includes a plurality of discharge switches, and each discharge switch is connected to a discharge electrode;

The selection of discharge electrodes and the sequence of discharge are controlled by the setting of working parameters.

Further, the charging voltage is 1000v-5000v, the discharge pulse voltage is 1000v-5000v, the pulse pulse width is 2μs-50μs, the number of pulse groups is 1-15, and the number of pulse groups is 1-250 groups.

In summary, the present invention provides a high-frequency bipolar unrecoverable electroporation system, which includes an upper-level information management module, a lower-level computer control module, and a bipolar high-voltage pulse discharge circuit; the upper-level information management module receives the set The working parameters are transmitted to the lower computer control module, and then the control signal is generated and transmitted to the bipolar high voltage pulse discharge circuit to generate the bipolar high voltage pulse. Compared with the traditional unipolar irreversible electroporation pulse sequence, the present invention can better and more uniformly increase the induced transmembrane potential of closely-packed cells to the simulated electroporation threshold, thereby making the ablation area more uniform. The invention can achieve good tumor ablation effects and inhibit tumor growth, and has good safety and effectiveness.

Compared with the prior art, the present invention has the following advantages:

1. In the present invention, the patient only needs to undergo local anesthesia before the patient is treated.

2. The present invention can make the patient's tumor ablation area more uniform.

3. The present invention can accurately set bipolar pulse parameters.

4. The present invention is based on a high-speed digital signal microprocessor, high-speed real-time acquisition of high-voltage pulse feedback signals, real-time monitoring of high-voltage pulse discharge in the entire treatment process, and meets the real-time requirements in the working process of the system.

5. The present invention adopts bipolar pulse discharge of multiple electrodes. In the setting of the treatment area, the high-voltage steep pulse forms a network discharge area in the tissue, so that the effective irreversible electric field covers the tumor tissue as much as possible, reduces the blind area of ablation, and enhances the treatment. The effectiveness of the plan,

6. The output pulse form of the present invention is a form in which pulses with the same pulse width between 2us and 50us are alternately conducted between two electrodes.

7. The present invention has a good software and hardware protection mechanism to ensure the safety of the entire surgical treatment.

Description of the drawings

Figure 1 is a structural block diagram of the high-frequency bipolar unrecoverable electroporation system of the present invention;

2 is a structural block diagram of a high-frequency bipolar non-recoverable electroporation system according to a specific embodiment of the present invention;

3 is a flowchart of a control method of a high-frequency bipolar non-recoverable electroporation system according to a specific embodiment of the present invention;

Fig. 4 is a circuit principle diagram of a bidirectional high-voltage pulse discharge circuit according to a specific embodiment of the present invention.

Detailed ways

In order to make the objectives, technical solutions, and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments and with reference to the accompanying drawings. It should be understood that these descriptions are only exemplary, and are not intended to limit the scope of the present invention. In addition, in the following description, descriptions of well-known structures and technologies are omitted to avoid unnecessarily obscuring the concept of the present invention.

The present invention provides a high-frequency bipolar unrecoverable electroporation system, as shown in Figure 1, comprising an upper-level information management module, a lower computer control module and a bipolar high-voltage pulse discharge circuit; the upper-level information management module receives the set The working parameters are transmitted to the lower computer control module; the lower computer control module generates control signals according to the working parameters transmitted by the upper information management module, and transmits the control signals to the bipolar high-voltage pulse discharge circuit to Control the charging and discharging parameters of the bipolar high-voltage pulse discharge circuit so that the bipolar high-voltage pulse discharge circuit generates bipolar high-voltage pulses; the bipolar high-voltage pulse discharge circuit generates positive and negative bipolar high-voltage pulses. The electrodes in the middle discharge, and the feedback signal is sent back to the upper information management module.

Further, as shown in Figure 2, the upper-level information management module includes an operating unit, a data processing unit, a display unit, and a transmission unit; the operating unit provides an interactive way for the operator to set various working parameters, and the The parameters are downloaded to the lower computer control module. The data processing unit processes the data to obtain the processing results; for example, processes various data collected by the control module and draws them into a curve. The display unit displays the interactive interface and the processing result, makes the data visible, and provides the operator with information such as the charging and discharging process. The transmission unit is used to transmit working parameters and/or control signals. In a specific embodiment, the upper-level information management module is a medical computer.

Further, the upper-level information management module further includes a compiling unit, which is used to provide a programming environment for the operator to realize the intelligent control of the discharge sequence of the system.

Further, the control module of the lower computer uses FPGA or CPLD and digital signal processor (DSP) as the central controller to control the charge and discharge of the bipolar high voltage pulse discharge circuit and control the charge and discharge feedback signal. Monitoring and collection. The lower computer control module includes a high-frequency bipolar pulse generation control unit, a timing function control unit and an acquisition unit.

Further, the high-frequency bipolar pulse generation control unit is used to generate a corresponding high-frequency bipolar pulse sequence according to the pulse parameters set by the upper-level information management module.

Further, the timing function control unit is used to control the charge and discharge switches in the charge and discharge circuit.

Further, the collection unit is used to monitor and collect the voltage and/or current during the charging and discharging process.

Further, it also includes a voltage/current detection circuit for detecting the voltage signal at the feedback signal point of the charging circuit of the system and the voltage and current signal at the feedback signal point of the bipolar high voltage pulse discharge circuit.

Furthermore, it also includes a photoelectric isolation module, which performs photoelectric isolation for all input and output signals to reduce the noise interference of external noise signals on the internal control module and improve the reliability of the control module. Specifically, the photoelectric isolation module includes a first photoelectric isolation unit and a second photoelectric isolation unit; the first photoelectric isolation unit performs photoelectric isolation for the control signal; and the second photoelectric isolation unit performs photoelectric isolation for the feedback signal.

In the following, a specific embodiment is used to further illustrate the high-frequency bipolar non-recoverable electroporation system of the present invention. As shown in Figure 3, the system includes an upper-level information management module and a bipolar high-voltage pulse discharge circuit. The upper-level information management module generates a corresponding control based on the input working parameters through the lower computer control module, the first photoelectric isolation unit and the power amplifier circuit. The signal is transmitted to the bipolar high voltage pulse discharge circuit; the bipolar high voltage pulse discharge circuit transmits the feedback signal back to the upper information management module through the voltage/current detection circuit, the second photoelectric isolation unit and the signal filter unit.

Further, as shown in FIG. 2, the bipolar high-voltage pulse discharge circuit includes a charging power supply, an energy storage capacitor group, a fast electronic switch group and a discharge electrode; the energy storage capacitor group is connected to the charging power supply through a charging switch, and The fast electronic switch group is connected with the discharge electrode; the fast electronic switch group is connected with the discharge electrode through a discharge switch. Among them, the fast electronic switch uses insulated gate bipolar transistors and is equipped with an IGBT drive circuit. Wherein, the energy storage capacitor group includes one or more large-capacity capacitors and one or more small-capacity capacitors; the large-capacity capacitors are connected in parallel with the small-capacity capacitors; the capacity of the large-capacity capacitors is 100uF-400uF; The capacity of the small capacitance capacitor is 0.1uF～1uF.

Further, it includes two charging switches; after the two resistors are connected in series, one end is set between the two charging switches, and the other end is grounded; a first feedback signal point is set between the two resistors, and the first The feedback signal is fed back to the upper-level information management module, and the first feedback signal is used for the detection of the charging voltage.

Further, it includes two of the discharge switches, each of which is connected to a discharge electrode to alternately discharge in bipolar; after the two resistors are connected in series, one end is connected between the fast electronic switch group and one of the discharge switches, and the other end is grounded A second feedback signal point is set between the two resistors, the generated second feedback signal is fed back to the upper-level information management module, and the second feedback signal is used for the detection of the discharge voltage.

Further, the settings of the charge and discharge parameters can be selected as follows: charge voltage is 1000v-5000v, discharge pulse voltage is 1000v-5000v, pulse width is 2μs-50μs, the number of group pulses is 1-15, and the number of pulse groups is 1-250 groups; among them, the number of group pulses is the number of pulses in each pulse group.

Further, a plurality of discharge switches may be included, and each discharge switch is connected to a discharge electrode; in this way, the selection of discharge electrodes and the discharge sequence can be controlled by setting the working parameters of the upper-level information management module.

The bipolar high-voltage pulse discharge circuit of the present invention is described below with a specific embodiment, in which two discharge electrodes are used as an example, but in practical applications, multiple discharge electrodes can also be selected as required. Fig. 4 is a circuit principle diagram of a bipolar high voltage pulse discharge circuit according to a specific embodiment of the present invention. As shown in Fig. 4, the bipolar high voltage pulse discharge circuit includes energy storage capacitor groups C1-C6 and C1 connected to the charging power supply U1. The pair of

discharge electrodes

1 and 2 are connected to the energy storage capacitor group through fast electronic switch groups K1-K4. There are charging switches KJ1 and KJ2 between the energy storage capacitor group and the charging power supply. Among them, G1 and G2 are the control signals of KJ1 respectively, and G3 and G4 are the control signals of KJ2 respectively. A discharge is provided between the fast electronic switch and the discharge electrode. Switches KJ3 and KJ4, where G5 and G6 are the control signals of KJ3 respectively, and G7 and G8 are the control signals of KJ4 respectively. Specifically, the charging switches KJ1 and KJ2 and the discharging switches KJ3 and KJ4 may adopt relays. The energy storage capacitor group is composed of one or more large-capacity capacitors of 100uF～400uF in parallel with one or more small-capacity capacitors of 0.1uF～1uF, which can supply large current in a short time and realize the rapid rise of current pulse. As shown in the figure, the energy storage capacitor group includes three large-capacity capacitors C1, C3, and C5 in series, and three small-capacity capacitors C2, C4, and C6 are connected in series and then connected in parallel.

The fast electronic switch group includes 4 fast electronic switches K1-K4, which use insulated gate bipolar transistors IGBTs and are equipped with IGBT drive circuits. K1 and K3 are connected in series, and K2 and K4 are connected in series respectively in parallel with the energy storage capacitor group; one end of the discharge switch KJ3 is connected between K1 and K3, and the other end is connected to one of the discharge electrode pairs; One end of the switch KJ4 is connected between K2 and K4, and the other end is connected to the other discharge electrode in the pair of discharge electrodes. The discharge switch KJ4 is connected to K2 and K4 through a resistor R5, and the resistor R5 acts as a current limiter. Among them, the resistance range of R5 can be selected as 0.05～0.3Ω, and the power limit is 5OW.

After the two resistors R1 and R4 are connected in series, one end is connected between the two charging switches KJ1 and KJ2, the other end is grounded, the first feedback signal point is set between the resistors R1 and R4, and the voltage/current detection circuit measures the first feedback signal point The signal is used to detect the charging voltage; J1 and J2 are the feedback signals of the charging voltage. After the two resistors R2 and R3 are connected in series, one end is connected between the midpoint of the fast electronic switches K1 and K3 and KJ3, and the other end is grounded and connected to KJ4 through R5. A second feedback signal point is set between the resistors R3 and R4. The voltage/current detection circuit measures the signal of the second feedback signal point for the detection of the discharge voltage; where J3 and J4 are the feedback signals of the discharge voltage. Among them, the resistance range of R1 can be 750K～1MΩ, and the power limit is 15W; the resistance range of R2 can be 75K～100KΩ, and the power limit is 15W; the resistance range of R3 can be 100～1000Ω, and the power limit is 1W; the resistance of R4 The value range can be 1K～10KΩ, and the power limit is 1W.

When the system is working, insert the discharge electrode into the lesion, and first close the charging switches KJ1 and KJ2 to charge the energy storage capacitor bank. When the voltage at point J1, that is, the first feedback signal point, reaches a predetermined value, the charging switches KJ1 and KJ2 are opened, and the discharging switches KJ3 and KJ4 are closed, and the energy storage capacitor group is discharged. The fast electronic switch forms high-frequency and high-voltage pulses under the action of the IGBT drive circuit. The pulse width can be set between 2us and 50μs, and pulses with the same pulse width are alternately conducted between the two discharge electrodes.

Multiple discharge electrodes can be selected for bipolar pulse discharge. In the setting of the treatment area, the high-voltage steep pulse forms a network-like discharge area in the tissue, so that the effective irreversible electric field covers the tumor tissue as much as possible, reduces the blind area of ablation, and enhances the treatment plan Effectiveness; on the rising edge of the pulse, the perforation of the cell is realized, and the perforation process is irreversible, thus realizing the cell inactivation.

The high-frequency bipolar non-recoverable electroporation system of the present invention uses a bipolar high-voltage pulse with a nanosecond-level rising edge to perform nanometer-level electroporation on the outer membrane of a biological cell to achieve an inactivation effect on the biological cell. The system is applied to tumor treatment, not only can realize the inactivation treatment of the tumor, but also can achieve the effect of minimally invasive and no thermal deposition. In addition, because irreversible electroporation can only perforate general tissue cells, it has no effect on connective tissue cells such as blood vessels and nerves. At the same time, high-frequency bipolar irreversible electroporation achieves local anesthesia, no muscle relaxant injection, and no breathing. Tumor ablation surgery under mechanical and mechanical ventilation fundamentally improves the safety and quality of surgery.

The present invention adopts the form of charging and discharging the capacitor bank, uses FPGA or CPLD and digital signal processor (DSP) as the central controller, and uses insulated gate bipolar transistor (IGBD) as the steep pulse generation switch. It produces bipolar high voltage pulses with a frequency of up to 250kHZ, the output voltage is 1000v-5000v, and the positive and negative pulses can be adjusted within the range of 2μs-50μs. Select the number of probes to be used (ie the number of discharge electrodes) and probe combinations (ie the selection of discharge electrodes) through the user interface, and set the voltage (1000v-5000v) and positive pulse width (2μs-50μs) through the electrode spacing ), negative pulse pulse width (2μs-50μs), the number of pulses in the group (1-15), the number of pulse groups (1 group-250 groups) and other parameters.

In summary, the present invention provides a high-frequency bipolar unrecoverable electroporation system, which includes an upper-level information management module, a lower computer control module, and a bipolar high-voltage pulse discharge circuit; the upper-level information management module receives the set The working parameters are transmitted to the lower computer control module, and then the control signal is generated and transmitted to the bipolar high voltage pulse discharge circuit to generate the bipolar high voltage pulse. Compared with the traditional unipolar irreversible electroporation pulse sequence, the present invention can better and more uniformly increase the induced transmembrane potential of closely-packed cells to the simulated electroporation threshold, thereby making the ablation area more uniform. The invention can achieve a good tumor ablation effect and the purpose of inhibiting tumor growth, and has good safety and effectiveness.

It should be understood that the above-mentioned specific embodiments of the present invention are only used to exemplarily illustrate or explain the principle of the present invention, and do not constitute a limitation to the present invention. Therefore, any modifications, equivalent substitutions, improvements, etc. made without departing from the spirit and scope of the present invention should be included in the protection scope of the present invention. In addition, the appended claims of the present invention are intended to cover all changes and modifications that fall within the scope and boundary of the appended claims, or equivalent forms of such scope and boundary.

Claims

A high-frequency bipolar unrecoverable electroporation system, which is characterized by comprising an upper-level information management module, a lower-level computer control module and a bipolar high-voltage pulse discharge circuit;

The upper-level information management module receives the set working parameters and transmits them to the lower computer control module;

The lower computer control module generates a control signal according to the working parameters transmitted by the upper information management module, and transmits the control signal to the bipolar voltage pulse discharge circuit to control the charging of the bipolar high voltage pulse discharge circuit. Discharge parameters, enabling the bipolar high voltage pulse discharge circuit to generate bipolar high voltage pulses;

The bipolar high-voltage pulse discharge circuit generates positive and negative bipolar high-voltage pulses, which are discharged by electrodes in the circuit, and feedback signals are transmitted back to the upper-level information management module.
The system according to claim 1, wherein the upper-level information management module includes an operation unit, a data processing unit, a display unit, and a transmission unit;

The operating unit provides an interactive way for setting working parameters;

The data processing unit processes the data to obtain a processing result;

The display unit displays the interactive interface and the processing result;

The transmission unit is used to transmit working parameters and/or control signals.
3. The system according to claim 2, further comprising a compiling unit for providing a programming environment to control the discharge sequence of the system.
The system according to any one of claims 1 to 3, wherein the lower computer control module further comprises a high-frequency bipolar pulse generation control unit, a timing function control unit, and an acquisition unit;

The high-frequency bipolar pulse generation control unit is used to generate a high-frequency bipolar pulse sequence;

The sequential function control unit is used to control the charge and discharge switches in the charge and discharge circuit;

The collection unit is used to monitor and collect the voltage and/or current during the charging and discharging process.
The system according to claim 1, wherein the charging and discharging parameters include charging voltage, discharging pulse voltage, pulse width, number of pulse groups, and number of pulse groups.
The system according to any one of claims 1 to 5, further comprising a power amplifier circuit, configured to amplify the power of the control signal and transmit it to the bipolar high voltage pulse discharge circuit.
The system according to any one of claims 1-6, further comprising a voltage/current detection circuit, which is used to detect the system charging voltage feedback signal, the high-voltage pulse discharge voltage and the discharge current feedback signal, and at the same time, the detection result Upload to the upper information management module.
The system according to any one of claims 1-7, further comprising a photoelectric isolation module, the photoelectric isolation module comprising a first photoelectric isolation unit and a second photoelectric isolation unit;

The first photoelectric isolation unit performs photoelectric isolation for the control signal;

The second photoelectric isolation unit performs photoelectric isolation for the feedback signal.
8. The system according to any one of claims 1-8, further comprising a signal filtering unit, which performs filtering processing on the feedback signal input by the bipolar high voltage pulse discharge circuit.
The system according to any one of claims 1-9, wherein the bipolar high-voltage pulse discharge circuit comprises a charging power supply, an energy storage capacitor group, a fast electronic switch group and a discharge electrode;

The energy storage capacitor group is connected to the charging power source through a charging switch, and is connected to the discharging electrode through the fast electronic switch group;

The fast electronic switch group is connected with the discharge electrode through a discharge switch.
The system according to claim 10, wherein the energy storage capacitor group comprises one or more large-capacity capacitors and one or more small-capacity capacitors;

The large-capacity capacitor and the small-capacity capacitor are connected in parallel;

The capacity of the large-capacity capacitor is 100 uF to 400 uF; the capacity of the small-capacity capacitor is 0.1 uF to 1 uF.
The system according to claim 10 or 11, characterized by comprising two charging switches KJ1 and KJ2;

After the two resistors R1 and R4 are connected in series, one end is arranged between the two charging switches KJ1 and KJ2, and the other end is grounded;

A first feedback signal point is set between the two resistors, and the generated first feedback signal is fed back to the upper-level information management module.
The system according to any one of claims 11-12, comprising two of the discharge switches KJ3 and KJ4, each of which is connected to a discharge electrode to alternately discharge in bipolar;

After the two resistors R2 and R3 are connected in series, one end is connected between the fast electronic switch group and KJ3, and the other end is grounded;

A second feedback signal point is set between the two resistors R2 and R3, and the generated second feedback signal is fed back to the upper-level information management module.
The system according to claim 10, characterized by comprising a plurality of discharge switches, each of which is connected to a discharge electrode;

The selection of discharge electrodes and the sequence of discharge are controlled by the setting of working parameters.
The system according to any one of claims 1-14, wherein the charging voltage is 1000v-5000v, the discharge pulse voltage is 1000v-5000v, the pulse width is 2μs-50μs, and the number of group pulses is 1-15 , The number of pulse groups is 1-250 groups.