CN114271930A - High-frequency bidirectional pulse treatment system for tumor treatment - Google Patents
High-frequency bidirectional pulse treatment system for tumor treatment Download PDFInfo
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Abstract
The invention provides a high-frequency bidirectional pulse treatment system for treating tumors, which comprises a first pulse module, a second pulse module, an acquisition treatment module and a processing and adjusting module; the first pulse module is used for transmitting a high-frequency pulse electric field from the positive direction, and the transmitting direction of the high-frequency pulse electric field of the first pulse module is a first pulse direction; the acquisition treatment module is used for acquiring operation parameters and body parameters in the operation process of the first pulse module and the second pulse module; the treatment adjusting module is used for processing the operation parameters and the body parameters acquired by the acquisition treatment module and adjusting the operation parameters of the first pulse module and the second pulse module according to the processing result.
Description
Technical Field
The invention relates to the technical field of high-frequency pulse treatment, in particular to a high-frequency bidirectional pulse treatment system for tumor treatment.
Background
The pulse generally refers to a kind of electrical shock which is used in electronic technology and is short-time fluctuating like pulse, and the bidirectional pulse refers to that two paths of pulse input and direction input are pulse input, only one path is forward pulse, and the other path is reverse pulse. The control mode is generally called forward pulse plus reverse pulse control mode. Clinically effective means for treating tumors are classified into 6 types: physical, chemical or biological methods. Such as surgery, radiation therapy, laser therapy, thermotherapy or cryoablation or killing tumors; the application of antitumor drugs, absolute alcohol or some viruses for local smearing or injection to kill tumors is the most important treatment method at present and should be selected firstly; second, internal medicine treatment, mainly various antitumor drugs; ③ biological treatment; monoclonal antibody for blocking tumor surface receptor (mainly growth receptor); blocking tumor new blood vessel; sixthly, the tumor regulating gene is changed. Among them, the application of pulsed electric fields is also becoming more and more widespread in the biomedical field.
In the prior art, in the process of treating tumor cells by using high-frequency pulses, a set program is generally adopted for treatment, but the treatment method has weak pertinence, pulse treatment parameters cannot be adjusted according to the actual treatment effect, and meanwhile, the existing treatment effect by adopting unidirectional pulses is poor.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a high-frequency bidirectional pulse treatment system for tumor treatment, which can adjust treatment parameters according to the actual treatment effect of a human body, thereby improving the pertinence of bidirectional treatment and solving the problem of poor pertinence and effect of the existing high-frequency pulse treatment.
In order to achieve the purpose, the invention is realized by the following technical scheme: the high-frequency bidirectional pulse treatment system for treating the tumor comprises a first pulse module, a second pulse module, an acquisition treatment module and a processing and adjusting module;
the first pulse module is used for transmitting a high-frequency pulse electric field from the positive direction, and the transmitting direction of the high-frequency pulse electric field of the first pulse module is a first pulse direction;
the second pulse module is used for transmitting the high-frequency pulse electric field from the reverse direction, and the transmitting direction of the high-frequency pulse electric field of the second pulse module is a second pulse direction;
the acquisition treatment module is used for acquiring operation parameters and body parameters in the operation process of the first pulse module and the second pulse module;
the processing and adjusting module is used for processing the operation parameters and the body parameters acquired by the acquisition and treatment module and adjusting the operation parameters of the first pulse module and the second pulse module according to the processing result.
Further, the collection treatment module comprises an operation collection unit, the operation collection unit is used for collecting operation parameters, and the operation parameters collected by the operation collection unit comprise: the first pulse module comprises a first pulse width, a first pulse amplitude difference, a first pulse repetition frequency and a first single pulse rise time, and the second pulse module comprises a second pulse width, a second pulse amplitude difference, a second pulse repetition frequency and a second single pulse rise time.
Further, the collection treatment module further comprises a body collection unit, the body collection unit is used for collecting body parameters, and the body parameters collected by the body collection unit include: a first value of cell transmembrane potential, a first cell conductivity, and a first cell perforated region area in a first pulse direction, and a second value of cell transmembrane potential, a second cell conductivity, and a second cell perforated region area in a second pulse direction.
Further, the processing adjustment module includes a preset unit, and the preset unit is configured with a preset policy, where the preset policy includes: controlling a first pulse module to send a high-frequency pulse electric field according to a first preset pulse width, a first preset pulse amplitude difference, a first preset pulse repetition frequency and a first preset single pulse rising time;
and controlling the second pulse module to send the high-frequency pulse electric field according to a second preset pulse width, a second preset pulse amplitude difference, a second preset pulse repetition frequency and a second preset single pulse rising time.
Further, the treatment adjustment module further comprises a body treatment unit configured with a body treatment strategy comprising: acquiring a first cell transmembrane potential value, a first cell conductivity and a first cell perforation area in a first pulse direction and a second cell transmembrane potential value, a second cell conductivity and a second cell perforation area in a second pulse direction at intervals of first time;
when the first times are obtained, substituting the obtained first cell transmembrane potential value, the first cell conductivity and the first cell perforation area in the first pulse direction of the first times into a first organism formula to obtain a first organism reference value; and substituting the acquired second cell transmembrane potential value, the acquired second cell conductivity and the acquired second cell perforation area in the second pulse direction of the first times into a second organism formula to obtain a second organism reference value.
Further, the first body formula is configured to:
the second body formula is configured to:
wherein P1jc is a first body reference value, Dw1 is a first cell transmembrane potential value, Dd1 is a first cell conductivity value, Sc1 is a first cell perforated region area, a1 is a first cell transmembrane potential reference coefficient, a2 is a first cell conductivity reference coefficient, a3 is a first cell perforated region area reference coefficient, P2jc is a second body reference value, Dw2 is a second cell transmembrane potential value, Dd2 is a second cell conductivity value, Sc2 is a second cell perforated region area, b1 is a second cell transmembrane potential reference coefficient, b2 is a second cell conductivity reference coefficient, and b3 is a second cell perforated region area reference coefficient.
Further, the processing adjustment module further includes an operation processing unit, where the operation processing unit is configured with an operation processing policy, and the operation processing policy includes: substituting the first body reference value and the first preset pulse width into a first pulse width formula to obtain a first pulse width adjustment value, substituting the first body reference value and the first preset pulse amplitude difference into a first pulse amplitude formula to obtain a first pulse amplitude adjustment value, substituting the first body reference value and the first preset pulse repetition frequency into a first pulse repetition formula to obtain a first pulse repetition frequency adjustment value, and substituting the first body reference value and the first preset single pulse rise time into a first single pulse formula to obtain a first single pulse rise time adjustment value;
substituting a second body reference value and a second preset pulse width into a second pulse width formula to obtain a second pulse width adjustment value, substituting a difference between the second body reference value and the second preset pulse amplitude into a second pulse amplitude formula to obtain a second pulse amplitude adjustment value, substituting the second body reference value and a second preset pulse repetition frequency into a second pulse repetition formula to obtain a second pulse repetition frequency adjustment value, and substituting the second body reference value and a second preset single pulse rise time into a second single pulse formula to obtain a second single pulse rise time adjustment value;
adjusting the output parameters of the high-frequency pulse electric field of the first pulse module according to the first pulse width adjustment value, the first pulse amplitude adjustment value, the first pulse repetition frequency adjustment value and the first single pulse rise time adjustment value; and adjusting the output parameters of the high-frequency pulse electric field of the second pulse module according to the second pulse width adjustment value, the second pulse amplitude adjustment value, the second pulse repetition frequency adjustment value and the second single pulse rise time adjustment value.
Further, the first pulse width formula is configured to: mkt1 ═ (c1 × Mky1)(P1jc+d1)(ii) a The first pulse amplitude formula is configured to: mft1 ═ c2 × Mfy1(P1jc+d2)(ii) a The first pulse repetition formula is configured to: mct1 ═ (c3 × Mcy1)(P1jc+d3)(ii) a The first single pulse formula is configured to: mdt1 ═ c 4X Mdy1(P1jc+d4)(ii) a Wherein Mkt1 is a first pulse width adjustment value, Mky1 is a first preset pulse width, c1 is a first preset pulse width reference coefficient, d1 is a first body and first pulse width compensation coefficient, Mft1 is a first pulse amplitude adjustment value, Mfy1 is a first preset pulse amplitude difference, c2 is a first pulse amplitude reference coefficient, d2 is a first body and first pulse amplitude compensation coefficient, Mct1 is a first pulse repetition frequency adjustment value, Mcy1 is a first preset pulse repetition frequency, c3 is a first pulse repetition frequency reference coefficient, d3 is a first body and first pulse repetition frequency compensation coefficient, Mdt1 is a first single pulse rise time adjustment value, Mdy1 is a first preset single pulse rise time, and c4 is a first single pulse rise timeA rise time reference coefficient, d4 is a first body and first single pulse rise time compensation coefficient;
the second pulse width formula is configured to: mkt2 ═ (e1 × Mky2)(P2jc+f1)(ii) a The second pulse amplitude formula is configured to: mft2 ═ e2 × Mfy2(P2jc+f2)(ii) a The second pulse repetition formula is configured to: mct2 ═ e3 × Mcy2(P2jc+f3)(ii) a The second single pulse formula is configured to: mdt2 ═ e 4X Mdy2(P2jc+f4)(ii) a Wherein Mkt2 is a second pulse width adjustment value, Mky2 is a second preset pulse width, e1 is a second preset pulse width reference coefficient, f1 is a second body and second pulse width compensation coefficient, Mft2 is a second pulse amplitude adjustment value, Mfy2 is a second preset pulse amplitude difference, e2 is a second pulse amplitude reference coefficient, f2 is a second body and second pulse amplitude compensation coefficient, Mct2 is a second pulse repetition frequency adjustment value, Mcy2 is a second preset pulse repetition frequency, e3 is a second pulse repetition frequency reference coefficient, f3 is a second body and second pulse repetition frequency compensation coefficient, Mdt2 is a second single pulse rise time adjustment value, Mdy2 is a second preset single pulse rise time, e4 is a second single pulse rise time reference coefficient, and f4 is a second body and second single pulse rise time compensation coefficient.
The invention has the beneficial effects that: the invention can send the high-frequency pulse electric field from the positive direction through the first pulse module, can send the high-frequency pulse electric field from the reverse direction through the second pulse module, then can obtain the operation parameters and the body parameters in the operation process of the first pulse module and the second pulse module through the acquisition treatment module, finally process the operation parameters and the body parameters obtained by the acquisition treatment module through the processing adjustment module, and adjust the operation parameters of the first pulse module and the second pulse module according to the processing result, and the mode can adjust the positive direction pulse parameters and the reverse direction pulse parameters in time according to the treatment effect of the body, thereby improving the pertinence of pulse treatment and being beneficial to improving the treatment effect.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:
FIG. 1 is a functional block diagram of the present invention;
fig. 2 is a functional block diagram of an embodiment of the present invention.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Referring to fig. 1, a high-frequency bidirectional pulse therapy system for tumor therapy includes a first pulse module, a second pulse module, an acquisition therapy module, and a processing adjustment module.
Specifically, in the embodiment, referring to fig. 2, the first pulse module is configured to send a high-frequency pulse electric field from a forward direction, and a sending direction of the high-frequency pulse electric field of the first pulse module is a first pulse direction; the second pulse module is used for transmitting the high-frequency pulse electric field from the reverse direction, and the transmitting direction of the high-frequency pulse electric field of the second pulse module is the second pulse direction. Through setting up two-way high frequency pulse electric field, can follow two directions and treat the cell, simultaneously in the treatment process, when the treatment effect in a certain direction is better, can strengthen the ascending treatment in this direction, reduce the ascending treatment in another direction to can improve the comprehensive of treatment.
The acquisition treatment module is used for acquiring operation parameters and body parameters in the operation process of the first pulse module and the second pulse module; the collection treatment module comprises an operation collection unit, the operation collection unit is used for collecting operation parameters, and the operation parameters collected by the operation collection unit comprise: the first pulse module comprises a first pulse width, a first pulse amplitude difference, a first pulse repetition frequency and a first single pulse rise time, and the second pulse module comprises a second pulse width, a second pulse amplitude difference, a second pulse repetition frequency and a second single pulse rise time.
The collection treatment module further comprises a body collection unit, the body collection unit is used for collecting body parameters, and the body parameters collected by the body collection unit comprise: a first value of cell transmembrane potential, a first cell conductivity, and a first cell perforated region area in a first pulse direction, and a second value of cell transmembrane potential, a second cell conductivity, and a second cell perforated region area in a second pulse direction. Wherein, the area of the cell perforation area is in direct proportion to the pulse width, and the rest operation parameters have important influence on the body parameters in the cell treatment process.
The processing and adjusting module is used for processing the operation parameters and the body parameters acquired by the acquisition and treatment module and adjusting the operation parameters of the first pulse module and the second pulse module according to the processing result.
The processing and adjusting module comprises a preset unit, the preset unit is configured with a preset strategy, and the preset strategy comprises: controlling a first pulse module to send a high-frequency pulse electric field according to a first preset pulse width, a first preset pulse amplitude difference, a first preset pulse repetition frequency and a first preset single pulse rising time;
and controlling the second pulse module to send the high-frequency pulse electric field according to a second preset pulse width, a second preset pulse amplitude difference, a second preset pulse repetition frequency and a second preset single pulse rising time. In the preset unit, the first preset pulse width, the first preset pulse amplitude difference, the second preset pulse width corresponding to the first preset pulse repetition frequency and the first preset monopulse rise time, the second preset pulse amplitude difference, the second preset pulse repetition frequency and the second preset monopulse rise time are respectively the same, so that the first preset pulse width, the first preset pulse amplitude difference, the second preset pulse repetition frequency and the second preset monopulse rise time are in the same treatment parameter state during initial treatment, subsequent treatment effects are convenient to compare, and meanwhile, the subsequent treatment parameters are convenient to adjust.
The treatment adjustment module further comprises a body treatment unit configured with a body treatment strategy comprising: acquiring a first cell transmembrane potential value, a first cell conductivity and a first cell perforation area in a first pulse direction and a second cell transmembrane potential value, a second cell conductivity and a second cell perforation area in a second pulse direction at intervals of first time;
when the first times are obtained, substituting the obtained first cell transmembrane potential value, the first cell conductivity and the first cell perforation area in the first pulse direction of the first times into a first organism formula to obtain a first organism reference value; and substituting the acquired second cell transmembrane potential value, the acquired second cell conductivity and the acquired second cell perforation area in the second pulse direction of the first times into a second organism formula to obtain a second organism reference value.
The first body formula is configured to:
the second body formula is configured to:
wherein P1jc is a first body reference value, Dw1 is a first cell transmembrane potential value, Dd1 is a first cell conductivity value, Sc1 is a first cell perforated region area, a1 is a first cell transmembrane potential reference coefficient, a2 is a first cell conductivity reference coefficient, a3 is a first cell perforated region area reference coefficient, P2jc is a second body reference value, Dw2 is a second cell transmembrane potential value, Dd2 is a second cell conductivity value, Sc2 is a second cell perforated region area, b1 is a second cell transmembrane potential reference coefficient, b2 is a second cell conductivity reference coefficient, b3 is a second cell perforated region area reference coefficient, wherein a1, a2, a3, b1, b2 and b3 are respectively larger than zero, the set reference coefficients are set based on the specific gravities of the respective corresponding values, the respective specific gravities are obtained from the results of the laboratory, and the specific gravities can be adjusted according to the actual treatment conditions.
The processing adjustment module further comprises an operation processing unit, the operation processing unit is configured with an operation processing strategy, and the operation processing strategy comprises: substituting the first body reference value and the first preset pulse width into a first pulse width formula to obtain a first pulse width adjustment value, substituting the first body reference value and the first preset pulse amplitude difference into a first pulse amplitude formula to obtain a first pulse amplitude adjustment value, substituting the first body reference value and the first preset pulse repetition frequency into a first pulse repetition formula to obtain a first pulse repetition frequency adjustment value, and substituting the first body reference value and the first preset single pulse rise time into a first single pulse formula to obtain a first single pulse rise time adjustment value;
substituting a second body reference value and a second preset pulse width into a second pulse width formula to obtain a second pulse width adjustment value, substituting a difference between the second body reference value and the second preset pulse amplitude into a second pulse amplitude formula to obtain a second pulse amplitude adjustment value, substituting the second body reference value and a second preset pulse repetition frequency into a second pulse repetition formula to obtain a second pulse repetition frequency adjustment value, and substituting the second body reference value and a second preset single pulse rise time into a second single pulse formula to obtain a second single pulse rise time adjustment value;
adjusting the output parameters of the high-frequency pulse electric field of the first pulse module according to the first pulse width adjustment value, the first pulse amplitude adjustment value, the first pulse repetition frequency adjustment value and the first single pulse rise time adjustment value; and adjusting the output parameters of the high-frequency pulse electric field of the second pulse module according to the second pulse width adjustment value, the second pulse amplitude adjustment value, the second pulse repetition frequency adjustment value and the second single pulse rise time adjustment value.
The first pulse width formula is configured to: mkt1 ═ (c1 × Mky1)(P1jc+d1)(ii) a The first pulse amplitude formula is configured to: mft1 ═ c2 × Mfy1(P1jc+d2)(ii) a The first pulse repetition formula is configured to: mct1 ═ (c3 × Mcy1)(P1jc+d3)(ii) a The first single pulse formula is configured to: mdt1 ═ c 4X Mdy1(P1jc+d4)(ii) a Wherein Mkt1 is a first pulse width adjustment value, Mky1 is a first preset pulse width, c1 is a first preset pulse width reference coefficient, d1 is a first body and first pulse width compensation coefficient, Mft1 is a first pulse amplitude adjustment value, Mfy1 is a first preset pulse amplitude difference, c2 is a first pulse amplitude reference coefficient, d2 is a first body and first pulse amplitude compensation coefficient, Mct1 is a first pulse repetition frequency adjustment value, Mcy1 is a first preset pulse repetition frequency, and c3 is a first pulse repetition frequencyA frequency reference coefficient, d3 is a first body and first pulse repetition frequency compensation coefficient, Mdt1 is a first single pulse rise time adjustment value, Mdy1 is a first preset single pulse rise time, c4 is a first single pulse rise time reference coefficient, and d4 is a first body and first single pulse rise time compensation coefficient; wherein c1, c2, c3, c4, d1, d2, d3 and d4 are respectively larger than zero, the setting standard is determined by the influence ratio of the corresponding values, the reference experiment result setting is set, and the adjustment can be carried out according to the actual treatment process.
The second pulse width formula is configured to: mkt2 ═ (e1 × Mky2)(P2jc+f1)(ii) a The second pulse amplitude formula is configured to: mft2 ═ e2 × Mfy2(P2jc+f2)(ii) a The second pulse repetition formula is configured to: mct2 ═ e3 × Mcy2(P2jc+f3)(ii) a The second single pulse formula is configured to: mdt2 ═ e 4X Mdy2(P2jc+f4)(ii) a Wherein Mkt2 is a second pulse width adjustment value, Mky2 is a second preset pulse width, e1 is a second preset pulse width reference coefficient, f1 is a second body and second pulse width compensation coefficient, Mft2 is a second pulse amplitude adjustment value, Mfy2 is a second preset pulse amplitude difference, e2 is a second pulse amplitude reference coefficient, f2 is a second body and second pulse amplitude compensation coefficient, Mct2 is a second pulse repetition frequency adjustment value, Mcy2 is a second preset pulse repetition frequency, e3 is a second pulse repetition frequency reference coefficient, f3 is a second body and second pulse repetition frequency compensation coefficient, Mdt2 is a second single pulse rise time adjustment value, Mdy2 is a second preset single pulse rise time, e4 is a second single pulse rise time reference coefficient, f4 is a second body and second single pulse rise time compensation coefficient, wherein e3, e 465, 5848 e, 465, e, 46573, and f 468 are included in the second pulse repetition frequency compensation coefficient, f3 and f4 are respectively larger than zero, the setting standard is determined by the influence ratio of the corresponding values, the reference experiment result setting is set, and the adjustment can be carried out according to the actual treatment process.
The working principle is as follows: in the actual treatment process, send high frequency pulse electric field from the forward through first pulse module, second pulse module is from reverse high frequency pulse electric field of sending, then can acquire operating parameter and the flesh parameter of first pulse module and second pulse module operation in-process through gathering the treatment module, data transmission to gathering to handling the adjustment module, the operating parameter and the flesh parameter that acquire the treatment module through handling the adjustment module, and adjust the operating parameter of first pulse module and second pulse module according to the treatment result, this mode can in time adjust forward and reverse pulse parameter according to the treatment effect of flesh, thereby improve the pertinence of pulse therapy.
Finally, it should be noted that: the above-mentioned embodiments are only specific embodiments of the present invention, which are used for illustrating the technical solutions of the present invention and not for limiting the same, and the protection scope of the present invention is not limited thereto, although the present invention is described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: any person skilled in the art can modify or easily conceive the technical solutions described in the foregoing embodiments or equivalent substitutes for some technical features within the technical scope of the present disclosure; such modifications, changes or substitutions do not depart from the spirit and scope of the embodiments of the present invention, and they should be construed as being included therein. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (9)
1. The high-frequency bidirectional pulse treatment system for treating the tumor is characterized by comprising a first pulse module, a second pulse module, an acquisition treatment module and a processing and adjusting module;
the first pulse module is used for transmitting a high-frequency pulse electric field from the positive direction, and the transmitting direction of the high-frequency pulse electric field of the first pulse module is a first pulse direction;
the second pulse module is used for transmitting the high-frequency pulse electric field from the reverse direction, and the transmitting direction of the high-frequency pulse electric field of the second pulse module is a second pulse direction;
the acquisition treatment module is used for acquiring operation parameters and body parameters in the operation process of the first pulse module and the second pulse module;
the processing and adjusting module is used for processing the operation parameters and the body parameters acquired by the acquisition and treatment module and adjusting the operation parameters of the first pulse module and the second pulse module according to the processing result.
2. The system of claim 1, wherein the acquisition module comprises an operation acquisition unit for acquiring operation parameters, and the operation acquisition unit acquires the operation parameters including: the first pulse module comprises a first pulse width, a first pulse amplitude difference, a first pulse repetition frequency and a first single pulse rise time, and the second pulse module comprises a second pulse width, a second pulse amplitude difference, a second pulse repetition frequency and a second single pulse rise time.
3. The system of claim 2, wherein the therapy acquisition module further comprises a body acquisition unit for acquiring body parameters, and the body parameters acquired by the body acquisition unit comprise: a first value of cell transmembrane potential, a first cell conductivity, and a first cell perforated region area in a first pulse direction, and a second value of cell transmembrane potential, a second cell conductivity, and a second cell perforated region area in a second pulse direction.
4. The system of claim 3, wherein the processing adjustment module comprises a preset unit configured with preset strategies, the preset strategies comprising: controlling a first pulse module to send a high-frequency pulse electric field according to a first preset pulse width, a first preset pulse amplitude difference, a first preset pulse repetition frequency and a first preset single pulse rising time;
and controlling the second pulse module to send the high-frequency pulse electric field according to a second preset pulse width, a second preset pulse amplitude difference, a second preset pulse repetition frequency and a second preset single pulse rising time.
5. The high frequency bi-directional pulse therapy system for oncology therapy of claim 4, wherein the treatment modification module further comprises a body treatment unit configured with a body treatment strategy comprising: acquiring a first cell transmembrane potential value, a first cell conductivity and a first cell perforation area in a first pulse direction and a second cell transmembrane potential value, a second cell conductivity and a second cell perforation area in a second pulse direction at intervals of first time;
when the first times are obtained, substituting the obtained first cell transmembrane potential value, the first cell conductivity and the first cell perforation area in the first pulse direction of the first times into a first organism formula to obtain a first organism reference value; and substituting the acquired second cell transmembrane potential value, the acquired second cell conductivity and the acquired second cell perforation area in the second pulse direction of the first times into a second organism formula to obtain a second organism reference value.
6. The high frequency bi-directional pulse therapy system for oncology therapy of claim 5, wherein the first body formula is configured to:
the second body formula is configured to:
wherein P1jc is a first body reference value, Dw1 is a first cell transmembrane potential value, Dd1 is a first cell conductivity value, Sc1 is a first cell perforated region area, a1 is a first cell transmembrane potential reference coefficient, a2 is a first cell conductivity reference coefficient, a3 is a first cell perforated region area reference coefficient, P2jc is a second body reference value, Dw2 is a second cell transmembrane potential value, Dd2 is a second cell conductivity value, and Sc2 is a second cell perforated region 2The area, b1 is a second cell transmembrane potential reference coefficient, b2 is a second cell conductivity reference coefficient, and b3 is a second cell transmembrane area reference coefficient.
7. The high frequency bi-directional pulse therapy system for oncology therapy of claim 6, wherein the process adaptation module further comprises an operational processing unit configured with an operational processing strategy comprising: substituting the first body reference value and the first preset pulse width into a first pulse width formula to obtain a first pulse width adjustment value, substituting the first body reference value and the first preset pulse amplitude difference into a first pulse amplitude formula to obtain a first pulse amplitude adjustment value, substituting the first body reference value and the first preset pulse repetition frequency into a first pulse repetition formula to obtain a first pulse repetition frequency adjustment value, and substituting the first body reference value and the first preset single pulse rise time into a first single pulse formula to obtain a first single pulse rise time adjustment value;
substituting a second body reference value and a second preset pulse width into a second pulse width formula to obtain a second pulse width adjustment value, substituting a difference between the second body reference value and the second preset pulse amplitude into a second pulse amplitude formula to obtain a second pulse amplitude adjustment value, substituting the second body reference value and a second preset pulse repetition frequency into a second pulse repetition formula to obtain a second pulse repetition frequency adjustment value, and substituting the second body reference value and a second preset single pulse rise time into a second single pulse formula to obtain a second single pulse rise time adjustment value;
adjusting the output parameters of the high-frequency pulse electric field of the first pulse module according to the first pulse width adjustment value, the first pulse amplitude adjustment value, the first pulse repetition frequency adjustment value and the first single pulse rise time adjustment value; and adjusting the output parameters of the high-frequency pulse electric field of the second pulse module according to the second pulse width adjustment value, the second pulse amplitude adjustment value, the second pulse repetition frequency adjustment value and the second single pulse rise time adjustment value.
8. The high frequency bi-directional pulse therapy system for oncology therapy of claim 7, wherein the first pulse width formula is configured to: mkt1 ═ (c1 × Mky1)(P1jc+d1)(ii) a The first pulse amplitude formula is configured to: mft1 ═ c2 × Mfy1(P1jc+d2)(ii) a The first pulse repetition formula is configured to: mct1 ═ (c3 × Mcy1)(P1jc+d3)(ii) a The first single pulse formula is configured to: mdt1 ═ c 4X Mdy1(P1jc+d4)(ii) a Wherein Mkt1 is a first pulse width adjustment value, Mky1 is a first preset pulse width, c1 is a first preset pulse width reference coefficient, d1 is a first body and first pulse width compensation coefficient, Mft1 is a first pulse amplitude adjustment value, Mfy1 is a first preset pulse amplitude difference, c2 is a first pulse amplitude reference coefficient, d2 is a first body and first pulse amplitude compensation coefficient, Mct1 is a first pulse repetition frequency adjustment value, Mcy1 is a first preset pulse repetition frequency, c3 is a first pulse repetition frequency reference coefficient, d3 is a first body and first pulse repetition frequency compensation coefficient, Mdt1 is a first single pulse rise time adjustment value, Mdy1 is a first preset single pulse rise time, c4 is a first single pulse rise time reference coefficient, and d4 is a first body and first single pulse rise time compensation coefficient.
9. The high frequency bi-directional pulse therapy system for oncology therapy of claim 8, wherein the second pulse width formula is configured to: mkt2 ═ (e1 × Mky2)(P2jc+f1)(ii) a The second pulse amplitude formula is configured to: mft2 ═ e2 × Mfy2(P2jc+f2)(ii) a The second pulse repetition formula is configured to: mct2 ═ e3 × Mcy2(P2jc+f3)(ii) a The second single pulse formula is configured to: mdt2 ═ e 4X Mdy2(P2jc+f4)(ii) a Wherein Mkt2 is a second pulse width adjustment value, Mky2 is a second preset pulse width, e1 is a second preset pulse width reference coefficient, f1 is a second body and second pulse width compensation coefficient, Mft2 is a second pulse amplitude adjustment value, Mfy2 is a second preset pulse amplitude difference, e2 is a second pulse amplitude reference coefficient, f2 is a second body and second pulse amplitude compensation coefficient, and Mct2 is a second pulse repetition frequencyThe adjustment values, Mcy2, e3, f3, Mdt2, Mdy2, e4, f4, are the second predetermined pulse repetition frequency, the second pulse repetition frequency compensation coefficient, the second body and the second pulse repetition frequency compensation coefficient, the second single pulse rise time adjustment value, the second predetermined single pulse rise time reference coefficient, and the second body and the second single pulse rise time compensation coefficient.
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| CN106388932A (en) * | 2016-07-12 | 2017-02-15 | 上海睿刀医疗科技有限公司 | Irreversible electroporation equipment |
| CN107681916A (en) * | 2017-09-22 | 2018-02-09 | 重庆大学 | One kind collaboration irreversible electroporation device of pulse |
| CN110946642A (en) * | 2019-12-13 | 2020-04-03 | 天津市鹰泰利安康医疗科技有限责任公司 | High-frequency bipolar unrecoverable electroporation system |
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2021
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160066977A1 (en) * | 2008-04-29 | 2016-03-10 | Angiodynamics, Inc. | System and Method for Ablating a Tissue Site by Electroporation with Real-Time monitoring of Treatment Progress |
| CN106388932A (en) * | 2016-07-12 | 2017-02-15 | 上海睿刀医疗科技有限公司 | Irreversible electroporation equipment |
| CN107681916A (en) * | 2017-09-22 | 2018-02-09 | 重庆大学 | One kind collaboration irreversible electroporation device of pulse |
| CN110946642A (en) * | 2019-12-13 | 2020-04-03 | 天津市鹰泰利安康医疗科技有限责任公司 | High-frequency bipolar unrecoverable electroporation system |
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