CN110914265B - 作为lsd-1抑制剂的吡咯并[2,3-c]吡啶和相关类似物 - Google Patents

作为lsd-1抑制剂的吡咯并[2,3-c]吡啶和相关类似物 Download PDF

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Publication number
CN110914265B
CN110914265B CN201880046207.9A CN201880046207A CN110914265B CN 110914265 B CN110914265 B CN 110914265B CN 201880046207 A CN201880046207 A CN 201880046207A CN 110914265 B CN110914265 B CN 110914265B
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hydrogen
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CN110914265A (zh
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王少萌
D·张
C·郑
Z·陈
L·刘
L·黄
C-Y·杨
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University of Michigan-Ann Arbor
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University of Michigan-Ann Arbor
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201880046207.9A 2017-05-15 2018-05-15 作为lsd-1抑制剂的吡咯并[2,3-c]吡啶和相关类似物 Active CN110914265B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762506349P 2017-05-15 2017-05-15
US62/506,349 2017-05-15
PCT/US2018/032619 WO2018213211A1 (en) 2017-05-15 2018-05-15 Pyrrolo[2,3-c]pyridines and related analogs as lsd-1 inhibitors

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CN110914265A CN110914265A (zh) 2020-03-24
CN110914265B true CN110914265B (zh) 2022-12-23

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US (1) US11168082B2 (cg-RX-API-DMAC7.html)
EP (1) EP3628044B1 (cg-RX-API-DMAC7.html)
JP (1) JP7352284B2 (cg-RX-API-DMAC7.html)
CN (1) CN110914265B (cg-RX-API-DMAC7.html)
AU (2) AU2018269947B2 (cg-RX-API-DMAC7.html)
WO (1) WO2018213211A1 (cg-RX-API-DMAC7.html)

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CN112119080B (zh) * 2018-05-15 2023-07-11 密歇根大学董事会 作为lsd-1抑制剂的咪唑并[4,5-c]吡啶化合物
SI3941466T1 (sl) 2019-03-20 2026-04-30 Oryzon Genomics, S.A. Vafidemstat za zdravljenje neagresivnih simptomov mejne osebnostne motnje
HRP20251471T1 (hr) 2019-03-20 2026-01-02 Oryzon Genomics, S.A. Postupci liječenja poremećaja hiperaktivnosti s deficitom pažnje korištenjem inhibitora kdm1a kao što je spoj vafidemstat
US20220227763A1 (en) 2019-05-29 2022-07-21 Syngenta Crop Protection Ag Microbiocidal derivatives
CN112451671B (zh) * 2020-12-02 2021-11-02 武汉大学 KDM1A在抑制RNA病毒刺激下干扰素IFNβ表达中的应用
CA3231846A1 (en) 2021-04-08 2022-10-13 Tamara Maes Combinations of lsd1 inhibitors for treating myeloid cancers
CN116102533A (zh) * 2021-11-11 2023-05-12 中国科学院上海药物研究所 一种芳杂环类化合物及其应用
JP2025503099A (ja) * 2022-01-25 2025-01-30 成都苑▲東▼生物制▲薬▼股▲ふん▼有限公司 ピリジン系誘導体、その製造方法及び使用
US20250295660A1 (en) 2022-05-09 2025-09-25 Oryzon Genomics, S.A. Methods of treating nf1-mutant tumors using lsd1 inhibitors
US20250275969A1 (en) 2022-05-09 2025-09-04 Oryzon Genomics, S.A. Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors
AU2023327925A1 (en) * 2022-08-22 2025-02-20 Redx Pharma Limited Pyrido-pyrazoles as inhibitors of ddr's for the treatment of fibrotic disorders and cancer
US20260151399A1 (en) 2022-11-24 2026-06-04 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors and menin inhibitors for treating cancer
WO2024208187A1 (zh) * 2023-04-03 2024-10-10 上海复星医药（集团）股份有限公司 氮杂芳基化合物及其作为lsd1抑制剂的用途
EP4784570A1 (en) * 2023-09-28 2026-08-05 The Regents of The University of Michigan Oxygenated heterocyclic lsd-1 inhibitors and related methods of use

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KR20150024669A (ko) * 2013-08-27 2015-03-09 제일모직주식회사 화합물, 이를 포함하는 유기발광소자 및 상기 유기발광소자를 포함하는 표시장치
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CN101307052A (zh) * 2007-05-14 2008-11-19 上海恒瑞医药有限公司 吡咯并n杂环类衍生物的制备方法及其在医药上的应用
KR20150024669A (ko) * 2013-08-27 2015-03-09 제일모직주식회사 화합물, 이를 포함하는 유기발광소자 및 상기 유기발광소자를 포함하는 표시장치
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AU2018269947A1 (en) 2019-12-19
JP7352284B2 (ja) 2023-09-28
CN110914265A (zh) 2020-03-24
AU2022200197A1 (en) 2022-02-10
WO2018213211A1 (en) 2018-11-22
US11168082B2 (en) 2021-11-09
AU2018269947B2 (en) 2021-10-14
JP2020519667A (ja) 2020-07-02
EP3628044A1 (en) 2020-04-01
US20200157091A1 (en) 2020-05-21
EP3628044B1 (en) 2023-11-22

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