CN110913892A - 包含癌抗原的lamp(溶酶体相关膜蛋白)构建物 - Google Patents

包含癌抗原的lamp(溶酶体相关膜蛋白)构建物 Download PDF

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Publication number
CN110913892A
CN110913892A CN201880029699.0A CN201880029699A CN110913892A CN 110913892 A CN110913892 A CN 110913892A CN 201880029699 A CN201880029699 A CN 201880029699A CN 110913892 A CN110913892 A CN 110913892A
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lamp
cells
antigen
protein
cell
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Chinese (zh)
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特瑞·海兰
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Immunomic Therapeutics Inc
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Immunomic Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
CN201880029699.0A 2017-05-02 2018-05-02 包含癌抗原的lamp(溶酶体相关膜蛋白)构建物 Pending CN110913892A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762500053P 2017-05-02 2017-05-02
US62/500,053 2017-05-02
US201762561760P 2017-09-22 2017-09-22
US62/561,760 2017-09-22
PCT/US2018/030725 WO2018204534A1 (en) 2017-05-02 2018-05-02 Lamp (lysosomal associated membrane protein) constructs comprising cancer antigens

Publications (1)

Publication Number Publication Date
CN110913892A true CN110913892A (zh) 2020-03-24

Family

ID=62528827

Family Applications (1)

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CN201880029699.0A Pending CN110913892A (zh) 2017-05-02 2018-05-02 包含癌抗原的lamp(溶酶体相关膜蛋白)构建物

Country Status (10)

Country Link
US (2) US12358962B2 (https=)
EP (1) EP3618854A1 (https=)
JP (3) JP7222915B2 (https=)
KR (2) KR20200016224A (https=)
CN (1) CN110913892A (https=)
AU (1) AU2018263923B9 (https=)
BR (1) BR112019023014A2 (https=)
CA (1) CA3061950A1 (https=)
IL (2) IL297073B2 (https=)
WO (1) WO2018204534A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12398195B2 (en) * 2018-05-15 2025-08-26 Immunomic Therapeutics, Inc. Lamp constructs comprising allergens
EP4045528A1 (en) * 2019-10-18 2022-08-24 Immunomic Therapeutics, Inc. Improved lamp constructs comprising cancer antigens
TWI828126B (zh) * 2021-04-27 2024-01-01 中央研究院 用以治療高三酸甘油脂血症或其相關疾病的方法
US20250352639A1 (en) 2022-04-10 2025-11-20 Immunomic Therapeutics, Inc. Bicistronic LAMP Constructs Comprising Immune Response Enhancing Genes and Methods of Use Thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040157307A1 (en) * 2001-04-05 2004-08-12 Harris Christopher John Chimeric vaccines
US20090093050A1 (en) * 2007-03-07 2009-04-09 Tzyy-Choou Wu DNA Vaccine Enhancement with MHC Class II Activators
CN101415827A (zh) * 2005-12-09 2009-04-22 阿哥斯医疗公司 产生抗原特异性效应t细胞的方法
CN103596974A (zh) * 2011-04-15 2014-02-19 卡姆普根有限公司 多肽和多核苷酸及其用于治疗免疫相关失调和癌症的用途

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Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
US20040157307A1 (en) * 2001-04-05 2004-08-12 Harris Christopher John Chimeric vaccines
US20170065712A1 (en) * 2001-04-05 2017-03-09 The Johns Hopkins University Chimeric vaccines
CN101415827A (zh) * 2005-12-09 2009-04-22 阿哥斯医疗公司 产生抗原特异性效应t细胞的方法
US20090093050A1 (en) * 2007-03-07 2009-04-09 Tzyy-Choou Wu DNA Vaccine Enhancement with MHC Class II Activators
CN103596974A (zh) * 2011-04-15 2014-02-19 卡姆普根有限公司 多肽和多核苷酸及其用于治疗免疫相关失调和癌症的用途

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AU2018263923B2 (en) 2024-08-22
IL297073B1 (en) 2023-08-01
JP2023036863A (ja) 2023-03-14
US20250333458A1 (en) 2025-10-30
JP7222915B2 (ja) 2023-02-15
CA3061950A1 (en) 2018-11-08
IL270271B2 (en) 2023-03-01
KR20240027895A (ko) 2024-03-04
JP7407902B2 (ja) 2024-01-04
US20200087365A1 (en) 2020-03-19
IL270271B (en) 2022-11-01
JP2024037951A (ja) 2024-03-19
WO2018204534A1 (en) 2018-11-08
IL270271A (https=) 2019-12-31
AU2018263923A1 (en) 2019-10-31
JP2020518613A (ja) 2020-06-25
BR112019023014A2 (pt) 2020-05-19
IL297073B2 (en) 2023-12-01
EP3618854A1 (en) 2020-03-11
IL297073A (en) 2022-12-01
US12358962B2 (en) 2025-07-15
AU2018263923B9 (en) 2024-09-19
JP7657282B2 (ja) 2025-04-04
KR20200016224A (ko) 2020-02-14

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