CN110903378A - 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂 - Google Patents

用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂 Download PDF

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CN110903378A
CN110903378A CN201911137855.8A CN201911137855A CN110903378A CN 110903378 A CN110903378 A CN 110903378A CN 201911137855 A CN201911137855 A CN 201911137855A CN 110903378 A CN110903378 A CN 110903378A
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protein
seq
factor
carcinoma
disease
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卡伊·克里斯托夫·沃勒特
莫蒂默·科尔夫-克林格比尔
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Medizinische Hochschule Hannover
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
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    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Communicable Diseases (AREA)
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  • Peptides Or Proteins (AREA)
CN201911137855.8A 2013-01-17 2014-01-16 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂 Pending CN110903378A (zh)

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EP13151593 2013-01-17
EP13151593.4 2013-01-17
CN201480005079.5A CN104968361B (zh) 2013-01-17 2014-01-16 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂

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CN201911137855.8A Pending CN110903378A (zh) 2013-01-17 2014-01-16 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂
CN201911124174.8A Pending CN110894226A (zh) 2013-01-17 2014-01-16 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂
CN201911137854.3A Active CN110922468B (zh) 2013-01-17 2014-01-16 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂
CN201911137853.9A Active CN111100197B (zh) 2013-01-17 2014-01-16 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂
CN201480005079.5A Active CN104968361B (zh) 2013-01-17 2014-01-16 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂
CN201911138039.9A Pending CN110922467A (zh) 2013-01-17 2014-01-16 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂

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CN201911137854.3A Active CN110922468B (zh) 2013-01-17 2014-01-16 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂
CN201911137853.9A Active CN111100197B (zh) 2013-01-17 2014-01-16 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂
CN201480005079.5A Active CN104968361B (zh) 2013-01-17 2014-01-16 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂
CN201911138039.9A Pending CN110922467A (zh) 2013-01-17 2014-01-16 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂

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CN115698048A (zh) 2020-01-21 2023-02-03 勃林格殷格翰国际有限公司 用于治疗或预防纤维化、肥大或心力衰竭的髓源性生长因子
CN114149500B (zh) * 2020-09-07 2023-12-01 复旦大学附属华山医院 抗人emc10的单克隆抗体在制备治疗和/或预防脂肪肝的产品中的应用
CN114149498B (zh) * 2020-09-07 2023-12-05 复旦大学附属华山医院 抗人emc10的单克隆抗体在防治2型糖尿病中的应用
CN114149499B (zh) * 2020-09-07 2023-12-05 复旦大学附属华山医院 抗人emc10的单克隆抗体及其在治疗和/或预防肥胖症中的应用
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US20080004232A1 (en) * 2006-05-09 2008-01-03 John Wilkins Characterization of c19orf10, a Novel Synovial Protein
CN102741288A (zh) * 2009-08-29 2012-10-17 雅培制药有限公司 治疗用dll4结合蛋白

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EP2945642A2 (en) 2015-11-25
JP2025143268A (ja) 2025-10-01
DK2945642T3 (da) 2024-05-27
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CN110922468A (zh) 2020-03-27
HUE068364T2 (hu) 2024-12-28
US10369198B2 (en) 2019-08-06
LT2945642T (lt) 2024-06-25
JP2016506911A (ja) 2016-03-07
WO2014111458A2 (en) 2014-07-24
EP3747457A2 (en) 2020-12-09
CN110922468B (zh) 2024-09-24
CN110922467A (zh) 2020-03-27
CN111100197B (zh) 2024-11-15
CN104968361B (zh) 2019-12-17
SI2945642T1 (sl) 2024-07-31
ES2986021T3 (es) 2024-11-08
CN110894226A (zh) 2020-03-20
PT2945642T (pt) 2024-05-27
EP2945642B1 (en) 2024-02-21
JP2020203894A (ja) 2020-12-24
JP7685737B2 (ja) 2025-05-30
CN104968361A (zh) 2015-10-07
JP2023025005A (ja) 2023-02-21
CA2898128A1 (en) 2014-07-24
PL2945642T3 (pl) 2024-07-29
JP6809789B2 (ja) 2021-01-06
HK1215540A1 (en) 2016-09-02
RS65553B1 (sr) 2024-06-28
US20150352186A1 (en) 2015-12-10
WO2014111458A3 (en) 2014-09-12
FI2945642T3 (fi) 2024-05-10
EP3747457A3 (en) 2021-03-03
CN111100197A (zh) 2020-05-05

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