CN110897911A - Novel anti-acne composition and application thereof in cosmetics - Google Patents
Novel anti-acne composition and application thereof in cosmetics Download PDFInfo
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- CN110897911A CN110897911A CN201911145798.8A CN201911145798A CN110897911A CN 110897911 A CN110897911 A CN 110897911A CN 201911145798 A CN201911145798 A CN 201911145798A CN 110897911 A CN110897911 A CN 110897911A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention belongs to a composition in the technical field of cosmetic compositions, and particularly relates to a novel anti-acne composition and application thereof in cosmetics. The anti-acne composition disclosed by the invention comprises components of a red pine leaf extract and a lactobacillus fermentation product. The anti-acne composition of the present invention is based on a group effect, and has the advantage of treatment while maintaining the balance of microbial communities. Safe and nontoxic, and has remarkable anti-acne effect.
Description
Technical Field
The invention belongs to a composition in the technical field of cosmetic compositions, and particularly relates to a novel anti-acne composition and application thereof in cosmetics.
Background
Propionibacteria are so named because they produce propionic acid, but in fact they are symbiotic on the skin of most healthy adults. Atopic dermatitis and psoriasis in the diseased state, the number of propionibacterium acnes is decreasing and increasing after treatment. The protective role of symbiotic states is largely unexplored and poorly understood. The skin microbiome of elderly healthy individuals is similar to that of younger healthy individuals and contains a large amount of propionibacterium acnes, which has the effect of maintaining healthy skin. Propionibacterium acnes have different genotypes, some are beneficial to the skin and some are harmful.
Propionibacterium acnes is the only bacterium capable of metabolizing our sebum because it secretes lipases, which can break down fatty acids, and secretes lipases to digest their primary energy source, sebum. Since propionibacteria play an important role in skin health, effective acne treatments should not target the killing of all propionibacteria as in current methods of treating acne, but should target pathogenic strains, or maintain or supplement beneficial strains, to maintain the health of the skin. Therefore, the development of a novel anti-acne product has good market application prospect.
Disclosure of Invention
The invention aims to provide a novel anti-acne composition.
Another object of the present invention is to provide an anti-acne cosmetic composition.
The invention also aims to provide the application of the anti-acne composition in cosmetics.
Still another object of the present invention is to provide an anti-acne essence.
In order to solve the technical problems, the invention designs a formula of a composition with an anti-acne effect, which comprises the following components: folium Pini Massonianae extract, and lactobacillus fermentation product.
In an alternative embodiment, the composition further comprises butanediol, dipropylene glycol and deionized water.
Among them, the alcohol is not limited to butanediol and dipropylene glycol.
As an alternative embodiment, the composition comprises the following components in percentage by weight: 5-20% of red pine leaf extract, 5-20% of lactobacillus fermentation product, 20-30% of butanediol, 15-20% of dipropylene glycol and 25-40% of deionized water.
As a preferred embodiment, the composition comprises the following components in percentage by weight: 10-20% of red pine leaf extract, 10-20% of lactobacillus fermentation product, 20-28% of butanediol, 15-18% of dipropylene glycol and 25-35% of deionized water.
As a more preferred embodiment, the composition comprises the following components in percentage by weight: 12-18% of red pine leaf extract, 12-18% of lactobacillus fermentation product, 20-25% of butanediol, 15-17% of dipropylene glycol and 28-32% of water.
As a further preferred embodiment, the composition comprises the following components in weight percent: 12-15% of red pine leaf extract, 12-16% of lactobacillus fermentation product, 21-23% of butanediol, 15-16% of dipropylene glycol and 30-32% of deionized water.
In another aspect, the invention provides a preparation method of the composition, which comprises the steps of uniformly stirring the red pine leaf extract, the lactobacillus fermentation product, butanediol, dipropylene glycol and deionized water at 20-30 ℃.
The composition of the present invention is mainly applied to cosmetics, but the specific cosmetics are not particularly limited; the cosmetic may be a lotion, cream, emulsion, gel or essence.
In a preferred embodiment, the cosmetic is essence.
Wherein the cosmetic contains the composition in a weight percentage of 1-5%.
As a preferred embodiment, the cosmetic composition comprises 1-2% by weight of the composition.
In another aspect, the present invention provides the use of said composition in cosmetics.
On the other hand, the invention provides an anti-acne essence containing the composition, which comprises the following components in percentage by weight: 1-5% of composition, 0.01-0.05% of EDTA disodium, 0.05-0.12% of allantoin, 1-10% of glycerol, 0.001-0.2% of sodium hyaluronate, 0.05-0.2% of methyl hydroxybenzoate, 0.01-0.2% of glycerol polyether-261-5% of hydrolyzed sclerotium rolfsii gum, 0.01-0.2% of xanthan gum, 1-5% of butanediol, 0.25-0.5% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.15-0.3% of aminomethyl propanol, 0.3-1% of phenoxyethanol and the balance of deionized water.
As a preferred embodiment, the acne-removing essence comprises the following components in percentage by weight: 1-2% of composition, 0.01-0.02% of EDTA disodium, 0.08-0.1% of allantoin, 3-5% of glycerol, 0.05-0.15% of sodium hyaluronate, 0.1-0.15% of methyl hydroxybenzoate, 0.05-3% of glycerol polyether, 0.05-0.1% of hydrolyzed sclerotium rolfsii gum, 0.05-0.15% of xanthan gum, 1-3% of butanediol, 0.3-0.4% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.18-0.24% of aminomethyl propanol, 0.4-0.6% of phenoxyethanol and the balance of deionized water.
In another aspect, the present invention provides a method for preparing the essence, comprising the steps of:
(1) sequentially adding deionized water, EDTA disodium, allantoin, glycerol, sodium hyaluronate, methylparaben, glyceryl polyether-26, hydrolyzed sclerotium rolfsii, xanthan gum, butanediol, acrylic acid (ester)/C10-30 alkanol propane into an emulsifying pot, stirring and heating, stirring uniformly until the materials are completely dissolved, homogenizing, and sterilizing;
(2) vacuumizing, cooling with cooling water, adding aminomethyl propanol, stirring, and homogenizing;
(3) cooling, adding the composition and phenoxyethanol, and stirring.
Compared with the prior art, one embodiment of the invention has the following beneficial technical effects:
(1) the balance of skin strains is kept, and the health state of the skin is kept; safe and nontoxic, and has remarkable anti-acne effect.
Detailed Description
The technical solutions of the present invention are further illustrated by the following specific examples, which do not represent limitations to the scope of the present invention. Insubstantial modifications and adaptations of the present invention by others of the concepts fall within the scope of the invention.
The red pine leaf extract used in the present invention is derived from Korean red pine.
Lactobacillus fermentation product: the manufacturer is france xiantang.
EXAMPLE 1 formulation and preparation of anti-acne composition
TABLE 1 formulation of anti-acne compositions
The preparation method comprises the following steps: stirring folium Pini Massonianae extract, lactobacillus fermentation product, butanediol, dipropylene glycol and deionized water at room temperature.
Example 2 cytotoxicity assay
According to the national standard GB/T16886.5-2003/ISO 10993-5 of the people's republic of China: 1999 cytotoxicity assays were performed. Biological model test of human epidermal keratinocytes was used.
The test samples included compositions 1, 3-4 and comparative compositions 1-3.
TABLE 2 cytotoxicity test results
| Composition comprising a metal oxide and a metal oxide | Results of cytotoxicity test |
| Comparative composition1 | Has no cytotoxicity |
| Comparative composition 2 | Has no cytotoxicity |
| Composition 1 | Has no cytotoxicity |
| Composition 3 | Has no cytotoxicity |
| Composition 4 | Has no cytotoxicity |
| Comparative composition 3 | Mild cytotoxicity |
The results showed that comparative composition 3 had cytotoxicity, demonstrating that cytotoxicity was exhibited when the contents of the red pine leaf extract and the lactobacillus fermentation product were each higher than 15%.
Example 3 acne removing essence
Compositions 1, 3 and 4 of example 1 and comparative compositions 1 to 2 were used to prepare acne-removing essences 1 to 5 (Table 3), respectively
TABLE 3 formula of acne-removing essence
The preparation method of the acne removing essence comprises the following steps:
1. sequentially adding the phase A into an emulsifying pot, stirring and heating to 80-85 ℃, uniformly stirring until the phase A is completely dissolved, homogenizing for 3 minutes, and sterilizing at constant temperature for 10 minutes.
2. Vacuumizing, cooling with cooling water, stirring at 800r/min, adding phase B at 60 deg.C, stirring, and homogenizing for 1 min.
3. When the temperature is reduced to 42 ℃, adding the phase C and the phase D, and stirring uniformly.
Example 4 acne treatment efficacy test
The effect test of the acne removing essence 1-5 in the embodiment 2 is as follows: 5 groups of volunteers aged 14-27 years (20, 10 males and 10 females per group) were selected for testing; the application method comprises cleaning face in the morning and evening, applying the acne-removing essence once, and comparing the analysis result with self-evaluation and photographing. The application time is 14 days. After 14 consecutive days of use, the test results are as follows:
acne removing essence 1: 98% of female acne skin volunteers feel obvious acne removing effect, and 97% of male acne skin volunteers feel obvious acne removing effect.
Acne removing essence 2: 30% of female acne skin volunteers feel obvious acne removing effect, and 25% of male acne skin volunteers feel obvious acne removing effect.
Acne removing essence 3: the acne removing effect is obvious in 28% of female acne skin volunteers, and is obvious in 26% of male acne skin volunteers.
Acne removing essence 4: 70% of female acne skin volunteers feel obvious acne removing effect, and 68% of male acne skin volunteers feel obvious acne removing effect.
Acne removing essence 5: 72% of female acne skin volunteers feel obvious acne removing effect, and 68% of male acne skin volunteers feel obvious acne removing effect.
As can be seen from the above results, the acne removing essence 1 is most effective in use, i.e., the anti-acne composition 4 is most effective.
Claims (10)
1. An anti-acne composition is characterized by comprising the following components: folium Pini Massonianae extract, and lactobacillus fermentation product.
2. The composition of claim 1, further comprising butylene glycol, dipropylene glycol, and deionized water;
preferably, the Pinus densiflora leaf extract is derived from Pinus densiflora.
3. The composition according to claim 1 or 2, comprising the following components in percentage by weight: 5-20% of red pine leaf extract, 5-20% of lactobacillus fermentation product, 20-30% of butanediol, 15-20% of dipropylene glycol and 25-40% of deionized water.
4. The composition according to claim 1 or 2, comprising the following components in percentage by weight: 10-20% of red pine leaf extract, 10-20% of lactobacillus fermentation product, 20-28% of butanediol, 15-18% of dipropylene glycol and 25-35% of deionized water;
preferably, the composition comprises the following components in percentage by weight: 12-18% of red pine leaf extract, 12-18% of lactobacillus fermentation product, 20-25% of butanediol, 15-17% of dipropylene glycol and 28-32% of deionized water;
more preferably, the composition comprises the following components in percentage by weight: 12-15% of red pine leaf extract, 12-16% of lactobacillus fermentation product, 21-23% of butanediol, 15-16% of dipropylene glycol and 30-32% of deionized water.
5. A process for preparing a composition according to any one of claims 1 to 4, comprising the steps of: uniformly stirring the red pine leaf extract, the lactobacillus fermentation product, butanediol, dipropylene glycol and deionized water at 20-30 ℃.
6. A cosmetic product comprising the composition of any of claims 1 to 4, wherein the cosmetic product comprises from 1% to 5% by weight of said composition;
preferably, the composition is contained in an amount of 1-2% by weight.
7. The cosmetic of claim 6, wherein the cosmetic is a lotion, cream, emulsion, jelly or essence;
preferably, the cosmetic is essence.
8. Use of a composition according to any one of claims 1 to 4 in cosmetics;
preferably, the cosmetic is a lotion, cream, emulsion, gel or essence;
more preferably, the cosmetic is essence.
9. An anti-acne essence containing the composition of any one of claims 1 to 4, wherein the anti-acne essence comprises the following components in percentage by weight:
1-5% of composition, 0.01-0.05% of EDTA disodium, 0.05-0.12% of allantoin, 1-10% of glycerol, 0.001-0.2% of sodium hyaluronate, 0.05-0.2% of methyl hydroxybenzoate, 0.01-0.2% of glycerol polyether-261-5% of hydrolyzed sclerotium rolfsii gum, 0.01-0.2% of xanthan gum, 1-5% of butanediol, 0.25-0.5% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.15-0.3% of aminomethyl propanol, 0.3-1% of phenoxyethanol and the balance of deionized water;
preferably, the composition comprises the following components in percentage by weight:
1-2% of composition, 0.01-0.02% of EDTA disodium, 0.08-0.1% of allantoin, 3-5% of glycerol, 0.05-0.15% of sodium hyaluronate, 0.1-0.15% of methyl hydroxybenzoate, 0.05-3% of glycerol polyether, 0.05-0.1% of hydrolyzed sclerotium rolfsii gum, 0.05-0.15% of xanthan gum, 1-3% of butanediol, 0.3-0.4% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.18-0.24% of aminomethyl propanol, 0.4-0.6% of phenoxyethanol and the balance of deionized water.
10. A method for preparing the anti-acne essence of claim 9, comprising the steps of:
(1) sequentially adding deionized water, EDTA disodium, allantoin, glycerol, sodium hyaluronate, methylparaben, glyceryl polyether-26, hydrolyzed sclerotium rolfsii, xanthan gum, butanediol, acrylic acid (ester)/C10-30 alkanol propane into an emulsifying pot, stirring and heating, stirring uniformly until the materials are completely dissolved, homogenizing, and sterilizing;
(2) vacuumizing, cooling with cooling water, adding aminomethyl propanol, stirring, and homogenizing;
(3) cooling, adding the composition and phenoxyethanol, and stirring.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911145798.8A CN110897911A (en) | 2019-11-21 | 2019-11-21 | Novel anti-acne composition and application thereof in cosmetics |
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| CN201911145798.8A CN110897911A (en) | 2019-11-21 | 2019-11-21 | Novel anti-acne composition and application thereof in cosmetics |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111568834A (en) * | 2020-06-29 | 2020-08-25 | 广州广妆生物科技有限公司 | Pure natural plant acne-removing and acne-removing mark-lightening composition, essence containing pure natural plant acne-removing and acne-lightening composition, and preparation method and application of pure natural plant acne-removing and acne-lightening composition |
| CN112043650A (en) * | 2020-10-26 | 2020-12-08 | 佛山天韵化妆品科技有限公司 | Acne-removing repairing cosmetic preparation and preparation method thereof |
| CN114344239A (en) * | 2021-11-24 | 2022-04-15 | 仙婷(广州)科技研发有限公司 | Acne-removing composition and preparation method thereof |
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2019
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| CN109394598A (en) * | 2018-12-17 | 2019-03-01 | 广州市仙婷贸易有限公司 | A kind of anti-acne concentrate and its application |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111568834A (en) * | 2020-06-29 | 2020-08-25 | 广州广妆生物科技有限公司 | Pure natural plant acne-removing and acne-removing mark-lightening composition, essence containing pure natural plant acne-removing and acne-lightening composition, and preparation method and application of pure natural plant acne-removing and acne-lightening composition |
| CN111568834B (en) * | 2020-06-29 | 2022-07-15 | 广州极男化妆品有限公司 | Pure natural plant acne-removing and acne-removing mark-lightening composition, essence containing pure natural plant acne-removing and acne-lightening composition, and preparation method and application of pure natural plant acne-removing and acne-lightening composition |
| CN112043650A (en) * | 2020-10-26 | 2020-12-08 | 佛山天韵化妆品科技有限公司 | Acne-removing repairing cosmetic preparation and preparation method thereof |
| CN112043650B (en) * | 2020-10-26 | 2021-08-17 | 佛山天韵化妆品科技有限公司 | Acne-removing repairing cosmetic preparation and preparation method thereof |
| CN114344239A (en) * | 2021-11-24 | 2022-04-15 | 仙婷(广州)科技研发有限公司 | Acne-removing composition and preparation method thereof |
| CN114344239B (en) * | 2021-11-24 | 2023-09-15 | 仙婷(广州)科技研发有限公司 | Acne-removing composition and preparation method thereof |
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Application publication date: 20200324 |