CN110891935B - 双环化合物及其在癌症治疗中的用途 - Google Patents

双环化合物及其在癌症治疗中的用途 Download PDF

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CN110891935B
CN110891935B CN201880040801.7A CN201880040801A CN110891935B CN 110891935 B CN110891935 B CN 110891935B CN 201880040801 A CN201880040801 A CN 201880040801A CN 110891935 B CN110891935 B CN 110891935B
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cancer
alkyl
haloalkyl
indole
benzyl
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CN110891935A (zh
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娅尔达·布拉沃
詹森·大卫·伯奇
奥斯汀·吉-宇·陈
乔·弗雷德·纳格米佐
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Tempest Therapeutics Inc
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/415—1,2-Diazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
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CN201880040801.7A 2017-04-18 2018-04-17 双环化合物及其在癌症治疗中的用途 Active CN110891935B (zh)

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US201762486765P 2017-04-18 2017-04-18
US62/486,765 2017-04-18
PCT/US2018/028034 WO2018195123A1 (en) 2017-04-18 2018-04-17 Bicyclic compounds and their use in the treatment of cancer

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EP (1) EP3612517B1 (enExample)
JP (1) JP7264060B2 (enExample)
KR (1) KR102588955B1 (enExample)
CN (1) CN110891935B (enExample)
AU (1) AU2018255300B2 (enExample)
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CN115448882A (zh) * 2021-06-08 2022-12-09 武汉人福创新药物研发中心有限公司 用于治疗ep2、ep4受体介导的疾病的苯并杂环化合物
WO2022257960A1 (zh) * 2021-06-08 2022-12-15 武汉人福创新药物研发中心有限公司 用于治疗ep2、ep4受体介导的疾病的双环化合物
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