CN110859897A - Fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome - Google Patents
Fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome Download PDFInfo
- Publication number
- CN110859897A CN110859897A CN201911217105.1A CN201911217105A CN110859897A CN 110859897 A CN110859897 A CN 110859897A CN 201911217105 A CN201911217105 A CN 201911217105A CN 110859897 A CN110859897 A CN 110859897A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- traditional chinese
- fermentation
- preventing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- General Health & Medical Sciences (AREA)
- Botany (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Birds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome, which comprises the following raw materials in parts by weight: 35-42 parts of astragalus membranaceus, 33-40 parts of acanthopanax, 28-35 parts of poplar flower, 22-28 parts of poria cocos, 18-25 parts of bighead atractylodes rhizome, 22-28 parts of rhizoma alismatis, 18-20 parts of dark plum, 18-25 parts of fructus forsythiae, 16-22 parts of honeysuckle, 15-18 parts of liquorice, and a plurality of clostridium butyricum for fermentation, lactobacillus acidophilus and fermentation products thereof. The traditional Chinese medicine fermentation preparation provided by the invention has the advantages that the traditional Chinese medicine is used as a fermentation raw material, the intermediate substance is subjected to biotransformation by using the preferred clostridium butyricum and lactic acid bacteria, the traditional Chinese medicine microecological preparation which is non-toxic, residue-free, green, easy to absorb and obviously enhanced in antibacterial activity is prepared, the drug effect is obviously improved, the preparation method of the traditional Chinese medicine fermentation preparation provided by the invention is simple and reasonable, the traditional Chinese medicine and the probiotics are combined in the traditional Chinese medicine fermentation preparation, the production period is short, and the cost is low.
Description
Technical Field
The invention relates to the technical field of fermented traditional Chinese medicine additives, in particular to a fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome.
Background
Postweaning Multisystemic Wasting Syndrome (PMWS) is caused by infection with circovirus (PVC 2), or by the synergistic effect of Porcine Parvovirus (PPV) and porcine reproductive and respiratory syndrome virus (PRRS). Pigs of 2-4 months age are easily infected, and the prevalence of infection usually occurs when PMWS appears. During this time, clinically infected pigs have higher virus concentrations in their serum, spreading large amounts of virus, and the results demonstrate that clinically infected pigs have a relatively weaker antibody response than subclinically infected pigs. The morbidity of an infected pig farm is generally 4-30%, the mortality is 4-20%, and PMWS is clinically characterized by emaciation, pale skin, dyspnea, and sometimes diarrhea and jaundice. Early clinical manifestations were subcutaneous lymphadenectasis. When the pigs in a pig farm only have the following diseases and pathological changes, the multi-system failure syndrome of the weaned piglets can be diagnosed: slow growth, emaciation, continuous dyspnea and enlargement of inguinal lymph nodes, jaundice sometimes occurs, the lymphatic tissue presents the characteristics of moderate to severe histopathological changes, and diseased lymphatic tissue or other tissues contain medium-titer to high-titer circovirus. However, the above characteristics do not exclude the possibility of other diseases coexisting with PMWS. The suspected PMWS-infected pigs are not visually susceptible to clinical symptoms or pathology sufficient to confirm the disease. The diagnosis of PMWS in a herd is mainly based on whether a certain number of pigs are thinned in the clinical process and whether the mortality rate exceeds the expected level, the diagnosis method is more accurate for the widely prevalent condition, but the PMWS can evolve into a more chronic and mild form and is only accompanied by lower death, which can increase the difficulty of diagnosis of a pig farm suspected to be infected with the PMWS and then inoculated with the circovirus disease vaccine.
There is no clear control measure for postweaning multisystemic wasting syndrome at present, and it is widely believed that the enhancement of management can reduce the incidence of diseases. PMWS can be induced by a number of factors in the management of newborn piglets, including over-immunization, unscientific weaning, mixed-herd feeding, and the like. Therefore, piglet care and management should be enhanced, reducing immune and environmental stress. The sow is fed in a full-in and full-out mode, the sow is limited from lactation, the cross lactation cannot be realized, the environment is comfortable, the reasonable feeding density is set, the air is fresh, a scientific immunization program is formulated, and the vaccine injection frequency is reduced as far as possible.
The method reduces the occurrence of multisystemic wasting syndrome of weaned pigs to a certain extent, but the effect is still not ideal. Therefore, the fermented traditional Chinese medicine additive for preventing the multisystemic wasting syndrome of the weaned pigs is provided.
Disclosure of Invention
The invention aims to provide a fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome, and aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
a fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome comprises the following raw materials in parts by weight: 35-42 parts of astragalus membranaceus, 33-40 parts of acanthopanax, 28-35 parts of poplar flower, 22-28 parts of poria cocos, 18-25 parts of bighead atractylodes rhizome, 22-28 parts of rhizoma alismatis, 18-20 parts of dark plum, 18-25 parts of fructus forsythiae, 16-22 parts of honeysuckle, 15-18 parts of liquorice, and a plurality of clostridium butyricum for fermentation, lactobacillus acidophilus and fermentation products thereof.
A fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome comprises the following raw materials in parts by weight: 38 parts of astragalus mongholicus, 33 parts of acanthopanax senticosus, 30 parts of poplar flower, 22 parts of poria cocos, 20 parts of bighead atractylodes rhizome, 22 parts of rhizoma alismatis, 18 parts of dark plum fruit, 18 parts of fructus forsythiae, 16 parts of honeysuckle and 15 parts of liquorice.
A preparation method of a fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome comprises the following specific steps:
s1: selecting traditional Chinese medicine extracts, weighing corresponding parts of astragalus root 38, acanthopanax root 33, poplar flower 30, poria cocos 22, bighead atractylodes rhizome 20, rhizoma alismatis 22, dark plum 18, fructus forsythiae 18, honeysuckle flower 16 and liquorice 15 to form mixed powder;
s2, uniformly mixing the mixed powder and a fermentation culture medium, inoculating probiotics, fermenting at 36-38 ℃ for 24-48 h to obtain a liquid traditional Chinese medicine fermentation mixture, and drying at 50-60 ℃ and spray-drying to obtain a powdery traditional Chinese medicine fermentation mixture;
and S3, drying and subpackaging the solid fermentation mixture and warehousing.
As a further scheme of the invention: the formula of the fermentation medium is as follows: 10 g of peptone, 10 g of beef powder, 3 g of yeast powder, 5 g of glucose, 1 g of soluble starch, 5 g of sodium chloride, 3 g of sodium acetate, 0.5 g of L-cysteine hydrochloride, 0.5 g of agar and 1000ml of purified water, mixing, adjusting the pH to 6-6.5 by using 10% sodium hydroxide solution, and sterilizing at 121 ℃ for 15min under high pressure.
As a further scheme of the invention: the probiotics are lactobacillus acidophilus and clostridium butyricum.
As a further scheme of the invention: the fermentation is carried out in a fermentation tank, and the fermentation conditions are as follows: the pressure is 0.02 kPa-0.1 kPa, the stirring speed is 10 r/min-30 r/min, and the pH value is 6.0-7.0.
As a further scheme of the invention: the adding ratio of the mixed powder to the fermentation medium is (8-20) g: 1L.
As a further scheme of the invention: the inoculated probiotics are second-stage seed liquid of probiotic strains, and the preparation steps of the second-stage seed liquid are as follows:
(1) activating probiotic strains, inoculating the activated probiotic strains into a seed culture medium, and statically culturing for 12-24 h at 36-38 ℃ to obtain a primary seed solution;
(2) inoculating the primary seed solution into a seed culture medium according to the inoculation amount of 2-10 vol%, and performing static culture at 36-38 ℃ for 12-24 h to obtain a secondary seed solution;
(3) and inoculating the secondary seed liquid according to the volume ratio of the secondary seed liquid to the fermentation culture medium of 3-8 vol%.
As a further scheme of the invention: the formula of the seed culture medium for preparing the first-stage seed liquid and the second-stage seed liquid is as follows: 10 g of refined peptone, 5 g of yeast extract, 20 g of glucose, 5 g of sodium acetate, 2 g of ammonium citrate, 0.1 g of tween 80, 0.58 g of magnesium sulfate, 0.28 g of manganese sulfate and 1000ml of distilled water.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine fermentation preparation provided by the invention has the advantages that the traditional Chinese medicine is used as a fermentation raw material, the intermediate substance is subjected to biotransformation by using the preferred clostridium butyricum and lactic acid bacteria, the traditional Chinese medicine microecological preparation which is non-toxic, residue-free, green, easy to absorb and obviously enhanced in antibacterial activity is prepared, the drug effect is obviously improved, the preparation method of the traditional Chinese medicine fermentation preparation provided by the invention is simple and reasonable, the traditional Chinese medicine and the probiotics are combined in the traditional Chinese medicine fermentation preparation, the production period is short, and the cost is low.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the embodiment of the invention, the basic composition data of the traditional Chinese medicine compound of the fermented traditional Chinese medicine additive for preventing the multisystemic wasting syndrome of the weaned pigs are shown in table 1:
TABLE 1 fermented Chinese medicinal additive for preventing postweaning multisystemic wasting syndrome
The Chinese medicinal extracts are weighed according to the requirements of table 1, and the fermented Chinese medicinal additive is prepared according to the following steps.
S2, uniformly mixing the mixed powder and a fermentation culture medium, inoculating probiotics, and fermenting at 36-38 ℃ for 24-48 h to obtain a liquid traditional Chinese medicine fermentation preparation;
and S3, respectively drying the liquid traditional Chinese medicine fermentation preparations, subpackaging and marking for later use.
Example 1
Application test of fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome
Hogfei in Huaibei city, Anhui province.
Hulaoban pig farm, 2019 for 3 months, and 200 weaned piglets (80 days old) in stock. The piglets presenting with multisystemic failure syndrome symptoms have 60 heads (diarrhea, asthma, low food consumption and light weight) and are divided into 3 groups, the drinking water of the test 1 group is added with a fermented traditional Chinese medicine additive (500 g of the product and 50kg of mixed materials) for preventing multisystemic failure syndrome of weaned piglets, the drinking water of the test 2 group is added with a fermented traditional Chinese medicine additive (500 g of the product and 50kg of mixed materials) for preventing multisystemic failure syndrome of weaned piglets, and the 3 rd group is a control group (regular health care and regular antibiotic addition in drinking water) and is shown in table 1.
TABLE 1 initial data of fermented Chinese medicinal additive application test for preventing postweaning multisystemic wasting syndrome
At the beginning of the test, the number of each group was consistent, and the body weight was consistent (the difference was not significant).
After the 45-day-old test was completed, the production data were obtained as follows:
at the end of the test, the body weight of the test group exceeded that of the control group (the difference was significant); the activity rate of the test composition is higher than that of the control group (the difference is obvious).
In summary, the following steps: the traditional Chinese medicine microecological preparation provided by the invention is reasonable in component proportion, takes traditional Chinese medicines as fermentation raw materials, utilizes the optimized clostridium butyricum and lactic acid bacteria to carry out biotransformation on intermediate substances, and is prepared into a non-toxic, residue-free, green, easily-absorbed and obviously-enhanced traditional Chinese medicine microecological preparation, so that the drug effect is obviously improved.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (9)
1. The fermented traditional Chinese medicine additive for preventing the comprehensive multiple system failure of weaned pigs is characterized by comprising the following components in parts by weight: 35-42 parts of astragalus membranaceus, 33-40 parts of acanthopanax, 28-35 parts of poplar flower, 22-28 parts of poria cocos, 18-25 parts of bighead atractylodes rhizome, 22-28 parts of rhizoma alismatis, 18-20 parts of dark plum, 18-25 parts of fructus forsythiae, 16-22 parts of honeysuckle, 15-18 parts of liquorice, and a plurality of clostridium butyricum for fermentation, lactobacillus acidophilus and fermentation products thereof.
2. The fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome according to claim 1, wherein the raw materials comprise the following components in parts by weight: 38 parts of astragalus mongholicus, 33 parts of acanthopanax senticosus, 30 parts of poplar flower, 22 parts of poria cocos, 20 parts of bighead atractylodes rhizome, 22 parts of rhizoma alismatis, 18 parts of dark plum fruit, 18 parts of fructus forsythiae, 16 parts of honeysuckle and 15 parts of liquorice.
3. A method for preparing a fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome according to any one of claims 1 to 2, which comprises the following steps:
s1: selecting traditional Chinese medicine extracts, weighing corresponding parts of astragalus root 38, acanthopanax root 33, poplar flower 30, poria cocos 22, bighead atractylodes rhizome 20, rhizoma alismatis 22, dark plum 18, fructus forsythiae 18, honeysuckle flower 16 and liquorice 15 to form mixed powder;
s2, uniformly mixing the mixed powder with a fermentation culture medium, inoculating probiotics, fermenting at 36-38 ℃ for 24-48 h to obtain a liquid traditional Chinese medicine fermentation mixture, and performing spray drying at 50-65 ℃ to obtain fermentation mixture powder;
and S3, subpackaging the solid fermentation mixture and warehousing.
4. The preparation method of the fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome according to claim 3, wherein the formula of the fermentation medium is as follows: 10 g of peptone, 10 g of beef powder, 3 g of yeast powder, 5 g of glucose, 1 g of soluble starch, 5 g of sodium chloride, 3 g of sodium acetate, 0.5 g of L-cysteine hydrochloride, 0.5 g of agar and 1000ml of purified water, mixing, adjusting the pH to 6-6.5 by using 10% sodium hydroxide solution, and sterilizing at 121 ℃ for 15min under high pressure.
5. The method for preparing fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome according to claim 3, wherein the probiotics are Lactobacillus acidophilus and Clostridium butyricum.
6. The method for preparing fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome according to claim 3, wherein the fermentation is performed in a fermentation tank under the following conditions: the pressure is 0.02 kPa-0.1 kPa, the stirring speed is 10 r/min-30 r/min, and the pH value is 6.0-7.0.
7. The preparation method of the fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome according to claim 3, wherein the adding ratio of the mixed powder to the fermentation medium is (8-20) g: 1L.
8. The method for preparing the fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome according to claim 3, wherein the inoculated probiotics are secondary seed liquid of probiotic strains, and the preparation steps of the secondary seed liquid are as follows:
(1) activating probiotic strains, inoculating the activated probiotic strains into a seed culture medium, and statically culturing for 12-24 h at 36-38 ℃ to obtain a primary seed solution;
(2) inoculating the primary seed solution into a seed culture medium according to the inoculation amount of 2-10 vol%, and performing static culture at 36-38 ℃ for 12-24 h to obtain a secondary seed solution;
(3) and inoculating the secondary seed liquid according to the volume ratio of the secondary seed liquid to the fermentation culture medium of 3-8 vol%.
9. The method for preparing the fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome according to claim 8, wherein a seed culture medium formula for preparing the primary seed solution and the secondary seed solution is as follows: 10 g of refined peptone, 5 g of yeast extract, 20 g of glucose, 5 g of sodium acetate, 2 g of ammonium citrate, 0.1 g of tween 80, 0.58 g of magnesium sulfate, 0.28 g of manganese sulfate and 1000ml of distilled water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911217105.1A CN110859897A (en) | 2019-12-03 | 2019-12-03 | Fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911217105.1A CN110859897A (en) | 2019-12-03 | 2019-12-03 | Fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110859897A true CN110859897A (en) | 2020-03-06 |
Family
ID=69657358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911217105.1A Pending CN110859897A (en) | 2019-12-03 | 2019-12-03 | Fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110859897A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618620A (en) * | 2020-07-20 | 2021-04-09 | 六安恒佳生物科技有限公司 | Solid-state fermentation traditional Chinese medicine additive for controlling respiratory diseases of laying fowls and preparation method thereof |
| CN113475633A (en) * | 2021-06-07 | 2021-10-08 | 吉林省农业科学院 | Fermented Chinese herbal medicine, method, feed and application applied to production of weaned piglets |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653520A (en) * | 2008-08-22 | 2010-02-24 | 天津生机集团股份有限公司 | Chinese medicament composition for preventing and treating piglet intractable diarrhea and preparation method thereof |
| CN104225032A (en) * | 2013-06-05 | 2014-12-24 | 天津君合心科技发展有限公司 | Antiviral compound traditional Chinese veterinary medicine ultra-fine powder for treating livestock and poultry infectivity |
| CN108541837A (en) * | 2018-07-02 | 2018-09-18 | 青岛手创业农牧科技集团股份有限公司 | A kind of feed addictive for weanling pig |
| CN108552429A (en) * | 2018-07-02 | 2018-09-21 | 青岛手创业农牧科技集团股份有限公司 | A kind of feed addictive for reducing weaned piglet growth disorder |
| CN109350655A (en) * | 2018-11-30 | 2019-02-19 | 河北征宇制药有限公司 | A kind of fermented tcm and preparation method thereof improving pig growth and reproductive performance |
| CN109498702A (en) * | 2018-12-26 | 2019-03-22 | 佛山市南海东方澳龙制药有限公司 | Fermented tcm preparation and its preparation method and application |
-
2019
- 2019-12-03 CN CN201911217105.1A patent/CN110859897A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653520A (en) * | 2008-08-22 | 2010-02-24 | 天津生机集团股份有限公司 | Chinese medicament composition for preventing and treating piglet intractable diarrhea and preparation method thereof |
| CN104225032A (en) * | 2013-06-05 | 2014-12-24 | 天津君合心科技发展有限公司 | Antiviral compound traditional Chinese veterinary medicine ultra-fine powder for treating livestock and poultry infectivity |
| CN108541837A (en) * | 2018-07-02 | 2018-09-18 | 青岛手创业农牧科技集团股份有限公司 | A kind of feed addictive for weanling pig |
| CN108552429A (en) * | 2018-07-02 | 2018-09-21 | 青岛手创业农牧科技集团股份有限公司 | A kind of feed addictive for reducing weaned piglet growth disorder |
| CN109350655A (en) * | 2018-11-30 | 2019-02-19 | 河北征宇制药有限公司 | A kind of fermented tcm and preparation method thereof improving pig growth and reproductive performance |
| CN109498702A (en) * | 2018-12-26 | 2019-03-22 | 佛山市南海东方澳龙制药有限公司 | Fermented tcm preparation and its preparation method and application |
Non-Patent Citations (2)
| Title |
|---|
| 杨元娟: "《生物药物检测技术》", 31 January 2017, 中国医药科技出版社 * |
| 高迎春: "《动物百病良方》", 31 October 2009, 山东科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618620A (en) * | 2020-07-20 | 2021-04-09 | 六安恒佳生物科技有限公司 | Solid-state fermentation traditional Chinese medicine additive for controlling respiratory diseases of laying fowls and preparation method thereof |
| CN113475633A (en) * | 2021-06-07 | 2021-10-08 | 吉林省农业科学院 | Fermented Chinese herbal medicine, method, feed and application applied to production of weaned piglets |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2020103400A4 (en) | A fermented plant feed additive for weaned piglet | |
| CN101664421B (en) | Traditional Chinese biological preparation for preventing and treating livestock diarrhea and preparation method and feedstuff thereof | |
| CN104222674B (en) | The preparation method of a kind of channel catfish Chinese medicine immunity enhancer and application | |
| CN107080074A (en) | Application of one boar food in in-pig cultivates | |
| CN103156061B (en) | Compound microbial active additive | |
| CN103005144B (en) | Traditional Chinese medicine microorganism fermentation preparation and preparation method thereof | |
| CN105614094A (en) | Fermented-feed raw material preparation special for pregnant sows and preparing method and application thereof | |
| CN109350655B (en) | Fermented traditional Chinese medicine for improving growth and reproductive performance of pigs and preparation method thereof | |
| CN112336828A (en) | Fermented traditional Chinese medicine microecological preparation for preventing and treating piglet diarrhea and preparation method thereof | |
| CN111184134A (en) | Beef cattle feed and preparation method thereof | |
| CN110859897A (en) | Fermented traditional Chinese medicine additive for preventing postweaning multisystemic wasting syndrome | |
| CN105613999A (en) | Enzyme capable of improving reproduction properties of breeding pigs and preparation method of enzyme | |
| CN107469056A (en) | A kind of female biochemical scattered, preparation method and application of fermented type benefit | |
| CN105267957B (en) | One boar biological antidiarrheic and its preparation method and application | |
| CN115444876B (en) | Fermented traditional Chinese medicine preparation for resisting porcine epidemic diarrhea virus and preparation method thereof | |
| CN103404709B (en) | Feed additive produced from waste liquid and dregs in pharmaceutical factory and preparation method of feed additive | |
| CN105124316A (en) | Biological fodder for promoting replacement gilt heat start, preparation method and application | |
| CN113967243B (en) | Fermented traditional Chinese medicine preparation for preventing and treating diarrhea of poultry and preparation method thereof | |
| CN113812522A (en) | Pig feed additive formula and pig feed prepared by same | |
| CN113080335A (en) | Fermented traditional Chinese medicine additive for improving egg poultry production performance and preparation method thereof | |
| CN109170322A (en) | Fermented tcm and preparation method thereof | |
| CN109924345A (en) | A kind of holothurian feed pre-mixing agent and preparation method thereof using the preparation of Chinese medicine residue | |
| CN116616366B (en) | Fermented nutritional composition for improving lactation capacity of sows as well as preparation method and application thereof | |
| CN107652034A (en) | A kind of antibacterial Aquaculture fertilizer | |
| CN111955616A (en) | Biological fermentation feed additive for pregnant sows and preparation and use methods thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20200306 |