CN110831932A - 晶体形式的n-[1-(5-氰基-吡啶-2-基甲基)-1h-吡唑-3-基]-2-[4-(1-三氟甲基-环丙基)-苯基]-乙酰胺 - Google Patents

晶体形式的n-[1-(5-氰基-吡啶-2-基甲基)-1h-吡唑-3-基]-2-[4-(1-三氟甲基-环丙基)-苯基]-乙酰胺 Download PDF

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Publication number
CN110831932A
CN110831932A CN201880044771.7A CN201880044771A CN110831932A CN 110831932 A CN110831932 A CN 110831932A CN 201880044771 A CN201880044771 A CN 201880044771A CN 110831932 A CN110831932 A CN 110831932A
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China
Prior art keywords
crystalline form
trifluoromethyl
pyrazol
phenyl
ylmethyl
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Pending
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CN201880044771.7A
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English (en)
Chinese (zh)
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比比亚·海德曼
马库斯·冯劳默尔
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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Publication of CN110831932A publication Critical patent/CN110831932A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201880044771.7A 2017-07-05 2018-07-04 晶体形式的n-[1-(5-氰基-吡啶-2-基甲基)-1h-吡唑-3-基]-2-[4-(1-三氟甲基-环丙基)-苯基]-乙酰胺 Pending CN110831932A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2017066806 2017-07-05
EPPCT/EP2017/066806 2017-07-05
PCT/EP2018/068087 WO2019008034A1 (en) 2017-07-05 2018-07-04 CRYSTALLINE FORM OF N- [1- (5-CYANO-PYRIDIN-2-YLMETHYL) -1H-PYRAZOL-3-YL] -2- [4- (1-TRIFLUOROMETHYL-CYCLOPROPYL) -PHENYL] -ACETAMIDE

Publications (1)

Publication Number Publication Date
CN110831932A true CN110831932A (zh) 2020-02-21

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Family Applications (1)

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CN201880044771.7A Pending CN110831932A (zh) 2017-07-05 2018-07-04 晶体形式的n-[1-(5-氰基-吡啶-2-基甲基)-1h-吡唑-3-基]-2-[4-(1-三氟甲基-环丙基)-苯基]-乙酰胺

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US (2) US11059803B2 (enExample)
EP (1) EP3649117B1 (enExample)
JP (2) JP2020525475A (enExample)
KR (1) KR102645911B1 (enExample)
CN (1) CN110831932A (enExample)
AU (1) AU2018296423B2 (enExample)
BR (1) BR112020000099A2 (enExample)
CA (1) CA3067489A1 (enExample)
CL (1) CL2020000002A1 (enExample)
EA (1) EA202090193A1 (enExample)
IL (1) IL271764B2 (enExample)
MA (1) MA50972A (enExample)
MY (1) MY206357A (enExample)
PH (1) PH12020500040A1 (enExample)
SG (1) SG11201912881SA (enExample)
UA (1) UA126582C2 (enExample)
WO (1) WO2019008034A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI808952B (zh) 2016-12-16 2023-07-21 瑞士商愛杜西亞製藥有限公司 包含t型鈣通道阻斷劑之醫藥組合
CN110234622B (zh) 2017-02-06 2023-07-04 爱杜西亚药品有限公司 用于合成1-芳基-1-三氟甲基环丙烷的新颖方法
KR102645911B1 (ko) * 2017-07-05 2024-03-08 이도르시아 파마슈티컬스 리미티드 N-[1-(5-시아노-피리딘-2-일메틸)-1h-피라졸-3-일]-2-[4-(1-트리플루오로메틸-시클로프로필)-페닐]-아세타미드의 결정질 형태
US20230047102A1 (en) 2019-12-20 2023-02-16 Idorsia Pharmaceuticals Ltd Pharmaceutical compositions comprising n-[1-(5-cyano-pyridin-2-ylmethyl)-1h-pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide
CN118202050A (zh) * 2021-08-17 2024-06-14 韩国科学技术院 靶向cav3.1基因的反义寡核苷酸及其用途
WO2023240205A1 (en) 2022-06-10 2023-12-14 Neurocrine Biosciences, Inc. Deuterated compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106414429A (zh) * 2014-06-03 2017-02-15 埃科特莱茵药品有限公司 吡唑化合物及其作为t型钙通道阻断剂的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6500092B2 (ja) 2014-09-15 2019-04-10 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｔ型カルシウムチャンネルブロッカーとしてのトリアゾール化合物
TWI808952B (zh) 2016-12-16 2023-07-21 瑞士商愛杜西亞製藥有限公司 包含t型鈣通道阻斷劑之醫藥組合
CN110234622B (zh) 2017-02-06 2023-07-04 爱杜西亚药品有限公司 用于合成1-芳基-1-三氟甲基环丙烷的新颖方法
KR102645911B1 (ko) * 2017-07-05 2024-03-08 이도르시아 파마슈티컬스 리미티드 N-[1-(5-시아노-피리딘-2-일메틸)-1h-피라졸-3-일]-2-[4-(1-트리플루오로메틸-시클로프로필)-페닐]-아세타미드의 결정질 형태

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106414429A (zh) * 2014-06-03 2017-02-15 埃科特莱茵药品有限公司 吡唑化合物及其作为t型钙通道阻断剂的用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
赵临襄: "《化学制药工艺学》", 中国医药科技出版社, pages: 405 *

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US11555025B2 (en) 2023-01-17
UA126582C2 (uk) 2022-11-02
BR112020000099A2 (pt) 2020-07-07
WO2019008034A1 (en) 2019-01-10
SG11201912881SA (en) 2020-01-30
EA202090193A1 (ru) 2020-06-03
JP2023123679A (ja) 2023-09-05
MA50972A (fr) 2020-10-14
US20200165221A1 (en) 2020-05-28
US11059803B2 (en) 2021-07-13
MY206357A (en) 2024-12-12
JP2020525475A (ja) 2020-08-27
IL271764B1 (en) 2023-06-01
IL271764A (en) 2020-02-27
EP3649117B1 (en) 2024-10-09
CA3067489A1 (en) 2019-01-10
KR102645911B1 (ko) 2024-03-08
CL2020000002A1 (es) 2020-07-31
US20210300894A1 (en) 2021-09-30
KR20200018698A (ko) 2020-02-19
PH12020500040A1 (en) 2020-10-12
IL271764B2 (en) 2023-10-01
AU2018296423A1 (en) 2020-02-20
AU2018296423B2 (en) 2022-07-28
EP3649117A1 (en) 2020-05-13

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