CN110812389A - Soluble granule for improving pig immunity and preparation method thereof - Google Patents
Soluble granule for improving pig immunity and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A61K9/1605—Excipients; Inactive ingredients
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Abstract
The invention discloses a soluble granule for improving pig immunity and a preparation method thereof, wherein the soluble granule is prepared from 30-40% of traditional Chinese medicine extract and 60-70% of auxiliary materials; the traditional Chinese medicine extract comprises the following components: dandelion extract, eucommia ulmoides leaf extract and macleaya cordata extract; in the dandelion extract, the weight content of flavone is more than or equal to 5 percent; in the eucommia ulmoides leaf extract, the weight content of chlorogenic acid is more than or equal to 5%, the weight content of eucommia ulmoides polysaccharide is more than or equal to 20%, and the weight content of eucommia ulmoides flavone is more than or equal to 8%; in the macleaya cordata extract, the weight content of sanguinarine is more than or equal to 40 percent, and the weight content of total alkali is more than or equal to 60 percent. The traditional Chinese medicine extract contains polysaccharides, alkaloids and the like, and can comprehensively adjust and exert the immune function and adaptability of the pig body, so that the disease resistance of the pig is obviously improved, the health condition of the pig is improved, the effects of preventing and treating diseases are achieved, the morbidity and mortality of the pig are reduced, and the breeding benefit and the breeding quality are improved.
Description
Technical Field
The invention relates to the technical field of veterinary drugs, and in particular relates to soluble granules for improving pig immunity and a preparation method thereof.
Background
Microelements, vitamins, chemical drugs, antibiotics and the like are added into the feed, certain effect is achieved on promoting the growth of pigs and preventing diseases, but drug residues caused by application of the chemical drugs, the antibiotics and the like seriously harm animal products and public health safety, and various countries are seeking green additives for replacing the chemical drugs and the antibiotics. Most of the traditional Chinese medicines are prepared from natural plants, are easy to absorb and utilize, have small toxic and side effects, have no drug resistance and do not pollute the environment, and are widely regarded for application and research in the pig industry. Therefore, it is necessary to provide a traditional Chinese medicine capable of improving pig immunity so as to reduce the harm caused by using antibiotics, chemicals and the like for livestock and poultry at present and solve the food safety problem concerned by people.
The dandelion (Latin scientific name: Taraxacum mongolicum hand. -Mazz.) is also called herba crotalariae albidae, herba sterculiae, and radix notoginseng florae, is a perennial herb of the Compositae, has wide application in traditional Chinese medicine, and has high medicinal value and nutritive value. In recent years, with the continuous and deep research on dandelion in clinical medicine, dandelion is found to have not only a very high nutritional value, but also a unique medicinal health-care function. Therefore, the dandelion has a wide development prospect in veterinary clinic. In addition, researches show that the dandelion water extract can effectively promote the immune cells and the non-immune function of animals to play, so that certain animals with damaged immune functions can recover the original immune capacity in a short time. The dandelion also contains a large amount of ferulic acid and oleanolic acid, the two substances can effectively promote gastrointestinal peristalsis of animals, and the two substances mainly act between the stomach and the duodenum, so that the dandelion can effectively relieve gastritis, stomachache and vomit of the animals, accelerate gastrointestinal peristalsis, stimulate appetite and improve feed utilization efficiency.
Eucommia ulmoides leaf (Latin's name: Eucomia folia), a natural Chinese herbal medicine, contains rich nutrients including VB1, VE, β -carotene, 17 kinds of free amino acids, 15 kinds of trace elements such as germanium and selenium, and the like.
Macleaya cordata (Latin's name: Macleaya cordia (Willd.) R.Br.) is also called Bischofia indica, Paulownia japonica etc., and is a perennial high herbaceous plant of Macleaya genus of Papaveraceae. Macleaya cordata has strong bactericidal and bacteriostatic activity, simultaneously has good anti-inflammatory and anti-arrhythmia effects, and has wider medicinal range in modern clinic.
Repeated experimental research by the inventor of the application discovers that the traditional Chinese medicine formula formed by compounding the dandelion, the eucommia ulmoides leaves and the macleaya cordata has an obvious effect of improving the immunity of the pigs. However, no report on the combination of the three traditional Chinese medicines for improving the immunity of the pigs is found so far.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention aims to provide soluble granules for improving the immunity of pigs and a preparation method thereof.
In order to achieve the purpose, the technical scheme adopted by the invention comprises the following aspects:
in a first aspect, the invention provides a traditional Chinese medicine extract for improving pig immunity, which comprises the following components: dandelion extract, eucommia ulmoides leaf extract and macleaya cordata extract.
According to the prescription principle of Chinese veterinarian monarch, minister, assistant and guide, the dandelion in the prescription has sweet flavor, has the effects of clearing heat and detoxicating, promoting urination and removing stasis, relieving diarrhea, dispelling wind, promoting digestion, enhancing immunity and the like, and is used as a main medicine in the prescription. The folium cortex eucommiae is warm in nature and taste, and has the effects of nourishing liver and kidney, strengthening bones and muscles, resisting bacteria, diminishing inflammation, resisting viruses, promoting gastric secretion and the like; the macleaya cordata is warm in nature and taste, and has the effects of dispelling wind, removing toxicity, promoting qi circulation, relieving swelling and killing parasites; folium Eucommiae and herba Macleayae Cordatae are used as adjuvant drugs. The three medicines are combined, so that the immunity of the pig can be obviously improved, and the immune system of the pig is activated.
Preferably, the weight content of the flavone in the dandelion extract is more than or equal to 5 percent; in the eucommia ulmoides leaf extract, the weight content of chlorogenic acid is more than or equal to 5%, the weight content of eucommia ulmoides polysaccharide is more than or equal to 20%, and the weight content of eucommia ulmoides flavone is more than or equal to 8%; in the macleaya cordata extract, the weight content of sanguinarine is more than or equal to 40 percent, and the weight content of total alkali is more than or equal to 60 percent. When the three traditional Chinese medicine extracts are in the specifications, the effect of improving the pig immunity is obvious.
Preferably, the traditional Chinese medicine extract comprises the following components in parts by weight: 60-120 parts of dandelion extract, 30-80 parts of eucommia ulmoides leaf extract and 5-20 parts of macleaya cordata extract.
Preferably, the traditional Chinese medicine extract comprises the following components in parts by weight: 90 parts of dandelion extract, 50 parts of eucommia ulmoides leaf extract and 12 parts of macleaya cordata extract.
Preferably, the preparation form of the traditional Chinese medicine extract is at least one of powder, tablets, powder, granules, oral liquid and injection.
In a second aspect, the invention provides soluble granules for improving pig immunity, which contain the traditional Chinese medicine extract for improving pig immunity.
Preferably, the soluble granules are prepared from 30-40% of the traditional Chinese medicine extract for improving the pig immunity and 60-70% of auxiliary materials by weight of 100% of the soluble granules.
Preferably, the adjuvant is selected from at least one of powdered sugar, starch, dextrin and lactose.
In a third aspect, the invention provides a preparation method of the soluble granules for improving the immunity of pigs, which comprises the following steps: weighing the dandelion extract, the eucommia ulmoides leaf extract, the macleaya cordata extract and the auxiliary materials according to the formula, respectively crushing, sieving by a 100-mesh sieve, adding an ethanol water solution with the mass concentration of 5-30%, sieving by a 24-mesh sieve to prepare wet granules, drying at 50-60 ℃, and finishing granules to obtain the soluble granules for improving the pig immunity.
Preferably, the drying time is 1-1.5 h.
Preferably, the adding amount of the ethanol water solution is 35 to 45 percent of the total weight of the auxiliary materials and the traditional Chinese medicine extract
In a fourth aspect, the invention provides the usage amount of the soluble granules for improving the pig immunity, and the additive amount of each ton of feed is 150-200 g/t for piglets, 90-120 g/t for middle pigs, 90-120 g/t for big pigs and 90-120 g/t for boars.
The invention has the beneficial effects that: the traditional Chinese medicine extract contains polysaccharides, alkaloids and the like, and can comprehensively adjust and exert the immune function and adaptability of the pig body, so that the disease resistance of the pig is obviously improved, the health condition of the pig is improved, the effects of preventing and treating diseases are achieved, the morbidity and mortality of the pig are reduced, and the breeding benefit and the breeding quality are improved.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention is further illustrated by the following examples. It is apparent that the following examples are only a part of the embodiments of the present invention, and not all of them. It should be understood that the embodiments of the present invention are only for illustrating the technical effects of the present invention, and are not intended to limit the scope of the present invention.
In the embodiment, the weight content of the flavone in the dandelion extract is more than or equal to 5 percent; the eucommia ulmoides leaf extract contains chlorogenic acid more than or equal to 5 wt%, eucommia ulmoides polysaccharide more than or equal to 20 wt% and eucommia ulmoides flavone more than or equal to 8 wt%; the sanguinarine content of the macleaya cordata extract is more than or equal to 40 percent, and the total alkali content is more than or equal to 60 percent. The above-mentioned specifications of the Chinese herbal medicine extract can be purchased commercially and are not described herein again.
Example 1
The soluble granule for improving the immunity of pigs comprises the following components in percentage by weight: 35% of traditional Chinese medicine extract, 18% of powdered sugar, 25% of starch, 9% of dextrin and 13% of lactose. The prescription of the traditional Chinese medicine extract comprises: 120 parts of dandelion extract, 80 parts of eucommia ulmoides leaf extract and 5 parts of macleaya cordata extract.
The preparation method of the soluble granules comprises the following steps: weighing the dandelion extract, the eucommia ulmoides leaf extract, the macleaya cordata extract and the auxiliary materials according to the formula, respectively crushing, sieving by a 100-mesh sieve, adding an ethanol water solution with the mass concentration of 5%, sieving by a 24-mesh sieve to prepare wet granules, drying at 50 ℃ for 1.5h, and finishing granules to obtain soluble granules; the addition amount of the ethanol water solution is 40% of the total weight of the auxiliary materials and the traditional Chinese medicine extract.
Example 2
The soluble granule for improving the immunity of pigs comprises the following components in percentage by weight: 35% of traditional Chinese medicine extract, 18% of powdered sugar, 25% of starch, 9% of dextrin and 13% of lactose. The prescription of the traditional Chinese medicine extract comprises: 90 parts of dandelion extract, 50 parts of eucommia ulmoides leaf extract and 12 parts of macleaya cordata extract.
The preparation method of the soluble granules comprises the following steps: weighing the dandelion extract, the eucommia ulmoides leaf extract, the macleaya cordata extract and the auxiliary materials according to the formula, respectively crushing, sieving by a 100-mesh sieve, adding an ethanol water solution with the mass concentration of 5%, sieving by a 24-mesh sieve to prepare wet granules, drying at 50 ℃ for 1.5h, and finishing granules to obtain soluble granules; the addition amount of the ethanol water solution is 40% of the total weight of the auxiliary materials and the traditional Chinese medicine extract.
Example 3
The soluble granule for improving the immunity of pigs comprises the following components in percentage by weight: 35% of traditional Chinese medicine extract, 18% of powdered sugar, 25% of starch, 9% of dextrin and 13% of lactose. The prescription of the traditional Chinese medicine extract comprises: 60 parts of dandelion extract, 30 parts of eucommia ulmoides leaf extract and 20 parts of macleaya cordata extract.
The preparation method of the soluble granules comprises the following steps: weighing the dandelion extract, the eucommia ulmoides leaf extract, the macleaya cordata extract and the auxiliary materials according to the formula, respectively crushing, sieving by a 100-mesh sieve, adding an ethanol water solution with the mass concentration of 5%, sieving by a 24-mesh sieve to prepare wet granules, drying at 50 ℃ for 1.5h, and finishing granules to obtain soluble granules; the addition amount of the ethanol water solution is 40% of the total weight of the auxiliary materials and the traditional Chinese medicine extract.
Example 4
The soluble granule for improving the immunity of pigs comprises the following components in percentage by weight: 30% of traditional Chinese medicine extract, 20% of powdered sugar, 25% of starch, 10% of dextrin and 15% of lactose. The prescription of the traditional Chinese medicine extract comprises: 90 parts of dandelion extract, 50 parts of eucommia ulmoides leaf extract and 12 parts of macleaya cordata extract.
The preparation method of the soluble granules comprises the following steps: weighing the dandelion extract, the eucommia ulmoides leaf extract, the macleaya cordata extract and the auxiliary materials according to the formula, respectively crushing, sieving by a 100-mesh sieve, adding an ethanol water solution with the mass concentration of 5%, sieving by a 24-mesh sieve to prepare wet granules, drying at 50 ℃ for 1.5h, and finishing granules to obtain soluble granules; the addition amount of the ethanol water solution is 45% of the total weight of the auxiliary materials and the traditional Chinese medicine extract.
Example 5
The soluble granule for improving the immunity of pigs comprises the following components in percentage by weight: 40% of traditional Chinese medicine extract, 15% of powdered sugar, 25% of starch, 10% of dextrin and 10% of lactose. The prescription of the traditional Chinese medicine extract comprises: 90 parts of dandelion extract, 50 parts of eucommia ulmoides leaf extract and 12 parts of macleaya cordata extract.
The preparation method of the soluble granules comprises the following steps: weighing the dandelion extract, the eucommia ulmoides leaf extract, the macleaya cordata extract and the auxiliary materials according to the formula, respectively crushing, sieving by a 100-mesh sieve, adding an ethanol water solution with the mass concentration of 5%, sieving by a 24-mesh sieve to prepare wet granules, drying at 50 ℃ for 1.5h, and finishing granules to obtain soluble granules; the addition amount of the ethanol water solution is 45% of the total weight of the auxiliary materials and the traditional Chinese medicine extract.
In order to verify the effect of the traditional Chinese medicine extract on improving the immunity of the pigs, the following clinical effect observation tests are carried out.
In 8 months 2014, 300 healthy weaned pigs exist in an Yinde pig farm in Qingyuan market, 300 weaned pigs are randomly divided into 6 groups, 5 groups are used as a test group, and the rest 1 group is used as a control group. The soluble granules of examples 1-5 (test group 1, test group 2, test group 3, test group 4, test group 5, and example 5) were added to the feed in an amount of 150 g/t; when in addition, the soluble granules are mixed into the feed, stirred evenly and fed directly. The control group did not add soluble granules to the feed. The test period was 30 days, and the number of deaths and diarrhea before and after the test were recorded, respectively, and the test results are shown in table 1.
TABLE 1
| Group of | Original quantity (head) | Death number (head) | Diarrhea digital (head) |
| Test group 1 | 50 | 3 | 5 |
| Test group 2 | 50 | 0 | 1 |
| Test group 3 | 50 | 5 | 8 |
| Test group 4 | 50 | 1 | 4 |
| Test group 5 | 50 | 0 | 2 |
| Control group | 50 | 9 | 17 |
As can be seen from the test results in Table 1, the death number and diarrhea number of the test group are obviously lower than those of the control group compared with the control group, which shows that the traditional Chinese medicine extract can effectively improve the immunity of pigs and reduce the death rate and diarrhea rate of the pigs. In the test group, the lowest death number and diarrhea number of the test group 2 indicate that the soluble granules in the example 2 have the most obvious effect on enhancing the immunity of the pigs, so the formula in the example 2 is taken as the preferable formula in the invention.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The traditional Chinese medicine extract for improving the pig immunity is characterized by comprising the following components: dandelion extract, eucommia ulmoides leaf extract and macleaya cordata extract; in the dandelion extract, the weight content of flavone is more than or equal to 5 percent; in the eucommia ulmoides leaf extract, the weight content of chlorogenic acid is more than or equal to 5%, the weight content of eucommia ulmoides polysaccharide is more than or equal to 20%, and the weight content of eucommia ulmoides flavone is more than or equal to 8%; in the macleaya cordata extract, the weight content of sanguinarine is more than or equal to 40 percent, and the weight content of total alkali is more than or equal to 60 percent.
2. The traditional Chinese medicine extract for improving the pig immunity according to claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 60-120 parts of dandelion extract, 30-80 parts of eucommia ulmoides leaf extract and 5-20 parts of macleaya cordata extract.
3. The traditional Chinese medicine extract for improving the pig immunity according to claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 90 parts of dandelion extract, 50 parts of eucommia ulmoides leaf extract and 12 parts of macleaya cordata extract.
4. The traditional Chinese medicine extract for improving the pig immunity according to any one of claims 1 to 3, wherein the traditional Chinese medicine extract is prepared in the form of at least one of powder, tablets, powder, granules, oral liquid and injection.
5. A soluble granule for enhancing pig immunity, which comprises the traditional Chinese medicine extract for enhancing pig immunity according to any one of claims 1 to 3.
6. The soluble granule for improving the pig immunity according to claim 5, wherein the soluble granule is prepared from 30-40% of the traditional Chinese medicine extract for improving the pig immunity according to any one of claims 1-3 and 60-70% of auxiliary materials, wherein the weight of the soluble granule is 100%.
7. The soluble granule for enhancing pig immunity according to claim 6, wherein the excipient is at least one selected from the group consisting of powdered sugar, starch, dextrin and lactose.
8. The preparation method of the soluble granule for improving the pig immunity according to any one of claims 5 to 7, which comprises the following steps: weighing the dandelion extract, the eucommia ulmoides leaf extract, the macleaya cordata extract and the auxiliary materials according to the formula, respectively crushing, sieving by a 100-mesh sieve, adding an ethanol water solution with the mass concentration of 5-30%, sieving by a 24-mesh sieve to prepare wet granules, drying at 50-60 ℃, and finishing granules to obtain the soluble granules for improving the pig immunity.
9. The method for preparing the soluble granule for improving pig immunity according to claim 8, wherein the drying time is 1-1.5 h.
10. The method for preparing the soluble granule for improving pig immunity according to claim 8, wherein the amount of the ethanol aqueous solution added is 35-45% of the total weight of the adjuvant and the Chinese medicinal extract.
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| CN201911211902.9A CN110812389B (en) | 2019-11-29 | 2019-11-29 | Soluble granule for improving pig immunity and preparation method thereof |
| PCT/CN2019/128186 WO2021103240A1 (en) | 2019-11-29 | 2019-12-25 | Soluble granule for improving pig immunity and method for preparation thereof |
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| CN107828866A (en) * | 2017-12-25 | 2018-03-23 | 云南牧道生物技术有限公司 | A kind of application for the macleaya cordata conditioning agent for improving weanling pig immune performance |
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| CN1299712C (en) * | 2005-02-25 | 2007-02-14 | 郁建生 | Plumepoppy injection |
| CN101554206B (en) * | 2009-05-14 | 2013-04-17 | 北京澳瑞思生物营养技术有限公司 | Composite plant feed additive |
| CN108635422B (en) * | 2018-07-24 | 2021-02-09 | 湖南美可达生物资源股份有限公司 | Composition for preventing and treating respiratory diseases of livestock and poultry and preparation method thereof |
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| CN107828866A (en) * | 2017-12-25 | 2018-03-23 | 云南牧道生物技术有限公司 | A kind of application for the macleaya cordata conditioning agent for improving weanling pig immune performance |
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| 侯博；等: "血根碱的生物学活性及博落回提取物在动物生产中的应用", 《动物营养学报》 * |
| 夏超笃；等: "博落回提取物对断奶仔猪生长性能、血清免疫指标及抗氧化指标的影响", 《中国畜牧兽医》 * |
| 孙珊珊；等: "蒲公英总黄酮含量测定及对小鼠体液免疫功能的影响", 《济宁医学院学报》 * |
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