CN104543363B - A kind of natural plants antibacterial feed additive for promoting growth and its application - Google Patents
A kind of natural plants antibacterial feed additive for promoting growth and its application Download PDFInfo
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Abstract
The present invention relates to a kind of feed addictive and its application.The feed addictive is made by the raw material of following parts by weight：It is made by the raw material of following parts by weight：It is made by the raw material of following parts by weight：50 150 parts of Astragalus Root P.E, 50 150 parts of eucommia ulmoides extracts, 50 150 parts of Honegsukle flower P.E, 50 150 parts of coptis extract, 50 100 parts of cinnamomum cassia extract, 50 100 parts of Turmeric P.E, 50 100 parts of Ramulus et Folium Picrasmae, 50 100 parts of dandelion extract, 50 100 parts of aloe extract, 50 100 parts of Semen Myristicae extract, 50 100 parts of licorice.Feed addictive of the present invention is that one kind is formulated relatively easy, effect stability and comprehensively safe and efficient plants antimicrobial feed additive for promoting growth；To gram-positive bacteria, Gram-negative bacteria, be respectively provided with good killing action, integrate restraining and sterilizing bacteria with it is antiviral, improve it is immune acted on premunition, can replacing whole feeding antibiotic, environmental protection, moderate cost, production method is easy, easy to operate.
Description
Technical field
The present invention relates to a kind of natural plants antibacterial feed additive for promoting growth and its application, belong to animal husbandry additive skill
Art field.
Background technology
Before long, we once by animal disease resistance the effect of give the credit to medicated premix (including feeding antibiosis
Element), a piece by a piece startling animal epidemics that can be broken out nearly ten years strike with food safety affair to our mankind
One and another alarm bell is rung.The Severe Acute Respiratory Syndromes of 2003, " bird flu " and " streptococcosis " of 2005 the, " height of 2006
Pathogenic blue otopathy " and " many treasured fish " and " red-yolk duck egg ", " melamine " of 2008, " the first stream " of 2009,2011
" clenbuterol hydrochloride ", " rapid-result chicken " of 2012 and " bird flu " event in 2013 be most strong witness.It is main former
Therefore one is to use substantial amounts of antibiotic.
In order to thoroughly solve the harm that feeding antibiotic is brought, existing many researchers are largely ground to this
Study carefully.CN103892049A discloses the plant feed additive and preparation method of a kind of prevention diarrhea of pigs.Its it is main by folium cortex eucommiae,
Lophatherum gracile, Poria cocos, honeysuckle, purslane, dandelion, radix glycyrrhizae, orange peel, red clover are extracted through compound and obtained.It is only capable of improving
The immunity of live pig, without antibacterial functions；CN103355545A discloses a kind of fermented type vegetalitas weanling pig feed and added
Plus agent, it is that, by the bark of eucommia, the Radix Astragali, honeysuckle, radix glycyrrhizae and dandelion etc. are directly crushed and be made, and not plant extracts product, leads
Cause addition is excessive, exist using a series of problems, such as insufficient, side effect is difficult to control to, active ingredient is indefinite.
The content of the invention
In order to solve above-mentioned defect, the present invention provides a kind of green, safe and efficient natural plants antibacterial growth-promoting
Long feed addictive.
To achieve these goals, the present invention is adopted the following technical scheme that：
A kind of feed addictive, is made by the raw material of following parts by weight：50-150 parts of Astragalus Root P.E, eucommia ulmoides extracts
50-150 parts, 50-150 parts of Honegsukle flower P.E, 50-150 parts of coptis extract, 50-100 parts of cinnamomum cassia extract, turmeric extract
50-100 parts of thing, 50-100 parts of Ramulus et Folium Picrasmae, 50-100 parts of dandelion extract, 50-100 parts of aloe extract, nutmeg
50-100 parts of extract, 50-100 parts of licorice.
In feed addictive of the present invention, the extract of each raw material can use field of Chinese medicines general extraction methods
Obtain, such as water extraction, alcohol extracting, or the commercially available each raw extract of selection.Raw material is extracted in the present invention and is mainly purchased from Chengdu
Permanent Easthome reaches bio tech ltd, and each extract active constituent content is as follows.Astragalus Root P.E：Content >=60-65% is yellow
Astragalus polysaccharides (UV), content >=0.1-0.2% Astragaloside IVs (HPLC)；Eucommia ulmoides extracts：Drink water level, the chlorogenic acid of content >=3%
(HPLC)；Honegsukle flower P.E：Drinking-water level, content >=3-5% chlorogenic acids (HPLC)；Coptis extract：Drinking-water level (5:1)；Meat
Osmanthus extract：Drinking-water level (10:1)；Turmeric P.E：The curcumin (UV) of content >=0.9%；Ramulus et Folium Picrasmae：Drinking-water level (15:
1)；Dandelion extract：Spice level (10:1), the caffeic acid (HPLC) of content >=0.1%；Aloe extract：Drinking-water level, content >=
20% barbaloin (UV), the barbaloin (HPLC) of content >=10%；Semen Myristicae extract：The Dehydrodiisoeugenol of content >=0.08%
(UV)；Licorice：Spice level (6:1), the glycyrrhizic acid (UV) of content >=10%, the glycyrrhizic acid (HPLC) of content >=2%.
The present invention is by selecting a variety of natural plant extracts, with modern Chinese veterinarian's pharmacology opinion, reasonable disposition each component
With magnitude relation, gained feed addictive has strength antidiarrheal, reduces young animal Incidence of Diarrhea, improves survival rate and health is lived
Power；Disease resistance, reduces bacterium, viral disease incidence (such as livestock and poultry Escherichia coli, staphylococcus, shigella dysenteriae, typhoid fever bar
Bacterium, salmonella, Pseudomonas aeruginosa and transmissible gastroenteritis etc.；Poultry ewcastle disease, influenza, bursal disease, necrotic enteritis etc.；Fish
Hemorrhage, enteritis disease, fin rot, prawn white spot disease, support draw virosis, vibriosis, black gill disease, red leg disease etc.)；Body is improved to exempt from
Epidemic disease and premunition, promote growth, improve breeding performonce fo animals.Thus the use of alternative feeding antibiotic, is reduced or avoided dynamic
Medicament residue in produce product.
Feed addictive of the present invention can be made using this area customary preparation methods.
The present invention also provides application of the above-mentioned feed addictive in feed, can be made into the conventional agent that feed adds field
Type, preferably pulvis or particle.
As the preferred embodiment of the present invention, the bead dosage form is made by the raw material of following parts by weight：Astragalus extraction
120 parts of thing, 100 parts of eucommia ulmoides extracts, 120 parts of Honegsukle flower P.E, 110 parts of coptis extract, 100 parts of cinnamomum cassia extract, ginger
Yellow 70 parts of extract, 80 parts of Ramulus et Folium Picrasmae, 90 parts of dandelion extract, 60 parts of aloe extract, 60 parts of Semen Myristicae extract,
90 parts of licorice, 10 parts of binding agent, 10 parts of water.
Wherein, the binding agent is this area conven-tional adjuvants；It is preferred that cornstarch.
The bead dosage form is to add binding agent and/or excipient, water in proportion on the basis of above-mentioned feed addictive, is mixed
It is even, then through granulation, dry, sieving, produce.
Wherein, acceptable granule in feed can be made using oscillating granulation and fluid-bed drying in the bead dosage form
Type.
Feed addictive addition of the present invention can obtain unexpected effect in weanling pig, the feed of broiler chicken：
1) show through lot of experiments research, can be notable according to 0.04%~0.05% plus feed addictive of the present invention
Reduction diarrhea of weaned piglets rate 46.4%~75.1%, raising daily gain 5.5%~17.5%, improvement feedstuff-meat ratio 3.8%~
5.9%.
2) broiler growth 9.2% can be improved according to 0.015%~0.03% plus feed addictive of the present invention
~13.6%, improve feedstuff-meat ratio 7.3%~9.5%, reduce the death rate 33.9%~52.2%.
Feed addictive of the present invention is that one kind is formulated relatively easy, effect stability and comprehensively safe and efficient plant
Antibacterial feed additive for promoting growth；To gram-positive bacteria (such as staphylococcus aureus), Gram-negative bacteria (Escherichia coli,
Salmonella etc.), good killing action is respectively provided with, collection restraining and sterilizing bacteria is immunized with antiviral, raising and acts on one with premunition
Body, can replacing whole feeding antibiotic, environmental protection, moderate cost, production method is easy, easy to operate.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
In feed addictive of the present invention, the extract of each raw material can be obtained using field of Chinese medicines general extraction methods
Take, such as water extraction, alcohol extracting, or the commercially available each raw extract of selection.Raw material is extracted in the present invention mainly permanent purchased from Chengdu
Easthome reaches bio tech ltd, and each extract active constituent content is as follows.Astragalus Root P.E：Content >=60-65% the Radixs Astragali
Polysaccharide (UV), content >=0.1-0.2% Astragaloside IVs (HPLC)；Eucommia ulmoides extracts：Drink water level, the chlorogenic acid of content >=3%
(HPLC)；Honegsukle flower P.E：Drinking-water level, content >=3-5% chlorogenic acids (HPLC)；Coptis extract：Drinking-water level (5:1)；Meat
Osmanthus extract：Drinking-water level (10:1)；Turmeric P.E：The curcumin (UV) of content >=0.9%；Ramulus et Folium Picrasmae：Drinking-water level (15:
1)；Dandelion extract：Spice level (10:1), the caffeic acid (HPLC) of content >=0.1%；Aloe extract：Drinking-water level, content >=
20% barbaloin (UV), the barbaloin (HPLC) of content >=10%；Semen Myristicae extract：The Dehydrodiisoeugenol of content >=0.08%
(UV)；Licorice：Spice level (6:1), the glycyrrhizic acid (UV) of content >=10%, the glycyrrhizic acid (HPLC) of content >=2%.
The feed addictive of embodiment 1
Formula：
Astragalus Root P.E 120kg, eucommia ulmoides extracts 100kg, Honegsukle flower P.E 120kg, coptis extract 110kg, meat
Osmanthus extract 100kg, Turmeric P.E 70kg, quassia extract 80kg, dandelion extract 90kg, aloe extract 60kg, meat
Fructus Amomi Rotundus extract 60kg, licorice 90kg.
The feed addictive of embodiment 2
Formula：
Astragalus Root P.E 50kg, eucommia ulmoides extracts 50kg, Honegsukle flower P.E 50kg, coptis extract 50kg, Chinese cassia tree carry
Thing 50kg, Turmeric P.E 50kg, quassia is taken to extract 50kg, dandelion extract 50kg, aloe extract 100kg, nutmeg
Extract 50kg, licorice 50kg.
The feed addictive of embodiment 3
Formula：
Astragalus Root P.E 150kg, eucommia ulmoides extracts 150kg, Honegsukle flower P.E 150kg, coptis extract 50kg, Chinese cassia tree
Extract 80kg, Turmeric P.E 100kg, quassia extract 100kg, dandelion extract 100kg, aloe extract 50kg, meat
Fructus Amomi Rotundus extract 100kg, licorice 100kg.
The preparation method of the feed addictive of embodiment 4
According to the formula of embodiment 1, each raw material is poured into regulation mixer successively, starts mixer, is sufficiently mixed
Uniformly, incorporation time is 2 minutes, produces its powder product.
The preparation method of the feed addictive of embodiment 5
Method according to embodiment 4 prepares the feed addictive described in embodiment 2.
The preparation method of the feed addictive of embodiment 6
Method according to embodiment 4 prepares the feed addictive described in embodiment 3.
The feed addictive particle of embodiment 7
Formula：On the basis of being formulated described in embodiment 1, addition binding agent 10kg, water 10kg.
The preparation method of the feed addictive particle of embodiment 8
It is formulated, each component is mixed, then through oscillating granulation, fluidized bed drying, sieving according to described in embodiment 7, is produced
Granula type.
The granular preparation of feed addictive described in embodiment 2,3 is prepared in the same manner.
The effect expedition that experimental example 1 is applied in early-weaned pigletses daily ration
1 materials and methods
1.1 experimental animals and packet
Experiment is carried out on In Shunyi District of Beijing Chen Ge village pig farm.
From 20 ages in days, blood relationship and body weight, all close to greatly enhance north (Yorkshire × length white × Pig Beijing Black) three way cross disconnected
Milk piglet 96, originates by body weight, sex and pedigree, and random district's groups are divided into 3 groups, every group of 4 repetition, often repeats 8 pigs, male and females
Half and half, corresponding daily ration is fed respectively, and (basal diet is identical, is shown in Table 1).Piglet routinely feeding and management method be managed and
Feeding, experimental period is 21 days.
Table 1
| Addition | |
| Control group 1 | 500mg/kg |
| Control group 2 | 500mg/kg |
| Embodiment 7 | 400mg/kg |
Note：Control group 1 is using compound collecting composition formula 1：100 parts of folium cortex eucommiae, 100 parts of lophatherum gracile, 70 parts of Poria cocos, honeysuckle
120 parts, 90 parts of purslane, 90 parts of dandelion, 90 parts of radix glycyrrhizae, 90 parts of orange peel, 70 parts of red clover, compound extract.
Control group 2 is using compound collecting composition formula 2：80 parts of Astragalus Root P.E, 80 parts of eucommia ulmoides extracts, Honegsukle flower P.E
70 parts, 70 parts of coptis extract, 50 parts of cinnamomum cassia extract thing, 50 parts of Turmeric P.E, quassia extract 80 parts, dandelion extract
90 parts, 60 parts of aloe extract, 60 parts of Semen Myristicae extract, 90 parts of licorice, 10 parts of binding agent, 10 parts of water.
1.2 test events and method
1.2.1 test and weighed on an empty stomach in 20 ages in days and 40 ages in days, record feed intake and grice diarrhoea number calculate piglet day
Weightening, feed intake, feed-weight ratio and diarrhea rate.
1.3 statistical analysis
Experiment acquired results carry out variance analysis and Multiple range test with SAS statistical softwares.
2 result of the tests
Table 2
| Index | Control group 1 | Control group 2 | Embodiment 7 |
| Starting weight (kg/) | 5.50 | 5.57 | 5.65 |
| End weight (kg/) | 12.00 | 12.93 | 13.28 |
| Increase weight (kg/) | 6.50a | 7.23b | 7.63a |
| Feedstuff-meat ratio | 1.30a | 1.24a | 1.25a |
| Diarrhea rate (%) | 8.5a | 4.3a | 2.2a |
In table 2, daily ration add embodiment 7 feed addictive granular preparation for the weightening of piglet, feedstuff-meat ratio,
The data of diarrhea rate are significantly better than that two control groups, show the feed addictive granular preparation of embodiment 7 and can substitute control completely
Two compounded combinations of group 1 and control group 2.
Application study of the experimental example 2 to broiler chicken
1 materials and methods
1.1 experimental animals and packet transaction
2400 1 age in days healthy AA broiler chicks are chosen, 3 groups are randomly divided into, are 4 repetitions per component, each repeatedly 200
Only.Each additive addition is shown in Table 1.
Test period：25 days, 6 weeks 13 days~October of September in 2011.
Table 1 adds scale
1.2 feeding management
Laying chicks fold the totally-enclosed raising of cage mode, chicken free choice feeding and drinking-water, daily cleaning up excrement using three layers of full weight, exempt from
Epidemic disease program is carried out by feed lot conventional method.
1.3 test index
Full group examination chicken starting weight, end weight, full period feed consumption rate and daily dead chicken number are determined in units of repeating groups.Calculate
Each group full period average body weight gains, feedstuff-meat ratio and death and culling rate.
2. result and analysis
Result of the test such as table 2.
Influence of the table 2 to broiler chicks production performance
| Index | Control group | Test group |
| Average weight (g/ is only) | 2313 | 2526 |
| Feedstuff-meat ratio | 1.93 | 1.79 |
| Death and culling rate (%) | 5.60 | 3.70 |
The feed addictive of embodiment 7 can significantly improve broiler chicks feedstuff-meat ratio as can be seen from Table 2, reduce death and culling rate, than
Significantly, the effect with substitute antibiotics is worth promoting conventional use of effects of antibiotics.
The fungistatic effect of the Substitutes For Antibiotic of test example 3 compares
The selection in the market effect preferably feed addictive with fungistatic effect does extracorporeal bacteria inhibitor test, and experiment is routinely
Method is carried out, as a result such as table 3.
Each Substitutes For Antibiotic of table 1 suppresses Escherichia coli, staphylococcus aureus effect list in vitro
Obtained from table 3 as drawn a conclusion：
1. the feed addictive granular preparation of embodiment 7 is to staphylococcus aureus (G+Representative bacterium) and Escherichia coli (G-
Representative bacterium) have inhibitory action, illustrate the feed addictive granular preparation of embodiment 7 to gram-positive bacteria and gram-negative
Property bacterium has inhibitory action.
2. compared with other kinds of antibiotic substitute, the feed addictive granular preparation of embodiment 7 is to golden yellow Portugal
Grape coccus, the fungistatic effect of Escherichia coli are superior to other kinds of product, illustrate that the present invention has excellent antibacterial effect.
3. compared with aureomycin, terramycin, the fungistatic effect of the feed addictive granular preparation of embodiment 7 is more preferable, explanation
The feed addictive granular preparation of embodiment 7 completely can be with the effect of substitute antibiotics.
4. the feed addictive granular preparation of embodiment 7 is compared with other kinds of antibiotic substitute, addition cost compared with
It is small, it is adapted to promote the use of.
Particle is made using the method for embodiment 7 in feed addictive obtained by embodiment 2-3, according to the method for above-mentioned experimental example
Detected, its result and embodiment 7 are basically identical, equally with good antibacterial growth promotion effect.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (8)
1. a kind of natural plants antibacterial feed additive for promoting growth, it is characterised in that be made by the raw material of following parts by weight：The Radix Astragali
50-150 parts of extract, 50-150 parts of eucommia ulmoides extracts, 50-150 parts of Honegsukle flower P.E, 50-150 parts of coptis extract, meat
Extract 50-100 parts of osmanthus, 50-100 parts of Turmeric P.E, 50-100 parts of Ramulus et Folium Picrasmae, 50-100 parts of dandelion extract,
50-100 parts of aloe extract, 50-100 parts of Semen Myristicae extract, 50-100 parts of licorice.
2. natural plants antibacterial feed additive for promoting growth according to claim 1, it is characterised in that by following parts by weight
Raw material be made：120 parts of Astragalus Root P.E, 100 parts of eucommia ulmoides extracts, 120 parts of Honegsukle flower P.E, 110 parts of coptis extract,
100 parts of cinnamomum cassia extract, 70 parts of Turmeric P.E, quassia extract 80 parts, 90 parts of dandelion extract, 60 parts of aloe extract,
60 parts of Semen Myristicae extract, 90 parts of licorice.
3. natural plants antibacterial feed additive for promoting growth according to claim 1, it is characterised in that described natural plant
The formulation that thing antibacterial feed additive for promoting growth is made is pulvis or particle.
4. natural plants antibacterial feed additive for promoting growth according to claim 3, it is characterised in that the bead dosage form
It is made by the raw material of following parts by weight：120 parts of Astragalus Root P.E, 100 parts of eucommia ulmoides extracts, 120 parts of Honegsukle flower P.E, the coptis
110 parts of extract, 100 parts of cinnamomum cassia extract, 70 parts of Turmeric P.E, 80 parts of quassia extraction, 90 parts of dandelion extract, aloe
60 parts of extract, 60 parts of Semen Myristicae extract, 90 parts of licorice, 10 parts of binding agent, 10 parts of water.
5. natural plants antibacterial feed additive for promoting growth according to claim 4, it is characterised in that the binding agent choosing
From cornstarch.
6. application of any described natural plants antibacterial feed additive for promoting growth of claim 1-5 in feed, its feature
It is, the feed is weanling pig, the feed of broiler chicken.
7. application of the natural plants antibacterial feed additive for promoting growth according to claim 6 in feed, its feature exists
In in the feed of the weanling pig, the consumption of feed addictive is 0.04%~0.05%.
8. application of the natural plants antibacterial feed additive for promoting growth according to claim 6 in feed, its feature exists
In in the feed of the broiler chicken, the consumption of feed addictive is 0.015%~0.03%.
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| CN104905059A (en) * | 2015-06-10 | 2015-09-16 | 青岛大信饲料有限公司 | Antibiotic-free milk replacer |
| CN105029104A (en) * | 2015-08-28 | 2015-11-11 | 青岛大信饲料有限公司 | Feed specially used for strengthening growing and fattening pigs |
| CN105166559A (en) * | 2015-09-30 | 2015-12-23 | 兴安县森澳养殖有限公司 | Chinese herbal medicine feed additive for pigs |
| CN106173254A (en) * | 2016-08-04 | 2016-12-07 | 湖南九鼎科技（集团）有限公司 | A kind of nonreactive child care pig's feed and preparation method thereof |
| CN107319155A (en) * | 2017-07-05 | 2017-11-07 | 北京四方红饲料科技有限公司 | A kind of young composite premixed feed for pigs and grain |
| CN107439897A (en) * | 2017-07-27 | 2017-12-08 | 磐安县派普特生物科技有限公司 | A kind of plant-based bacteriostat |
| CN110150469A (en) * | 2019-06-04 | 2019-08-23 | 上海同仁药业股份有限公司 | A kind of livestock and poultry premixed feed and its preparation and feeding method with antiviral efficacy |
| CN110279033A (en) * | 2019-08-01 | 2019-09-27 | 河南省兽药饲料监察所(河南省畜产品质量监测检验中心) | A kind of lupulus extract feed addictive and preparation method thereof |
| CN110786418A (en) * | 2019-10-09 | 2020-02-14 | 南京致润生物科技有限公司 | Composite feedable natural plant extract feed additive and preparation method thereof |
| CN112617017A (en) * | 2020-12-22 | 2021-04-09 | 宜兴市天石饲料有限公司 | Natural plant extraction type mildew preventive for preventing and treating feed mildew after long-term storage |
| CN113577251A (en) * | 2021-08-18 | 2021-11-02 | 罗泽鑫 | Fish gill rot disease treatment method |
| CN115553381A (en) * | 2022-08-22 | 2023-01-03 | 玉林师范学院 | Quassia extract, preparation method and application thereof |
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| CN1328971C (en) * | 1999-10-25 | 2007-08-01 | 江苏正昌集团公司 | Growth promoter of green natural plant |
| CN1273033C (en) * | 2003-07-31 | 2006-09-06 | 武汉工业学院 | Feed additive made of vegetable extractive |
| CN1620899A (en) * | 2005-01-05 | 2005-06-01 | 汪鲲 | Compound feed additive of plant polysaccharide, flavonoid extract for meat flavor improvement |
| CN1640294A (en) * | 2005-01-10 | 2005-07-20 | 南京福斯特牧业科技有限公司 | Disease-resistant growth-promoting Chinese medicine fodder additive for aquatic and domestic animal, and its preparing method |
| CN101524117B (en) * | 2009-04-21 | 2011-11-23 | 陆晓巍 | Plant medicine granule serving as feed additive for preventing and treating poultry and livestock diseases and preparation thereof |
| KR101130989B1 (en) * | 2009-11-27 | 2012-04-23 | 경상북도 (관련부서:경상북도축산기술연구소장) | A process for producing feedstuff additives comprising natural herbs and having a preventing activity of calf's diarrhea |
| CN102204629B (en) * | 2011-05-19 | 2012-11-21 | 浙江农林大学 | Feed additive and preparation method thereof |
| CN103843997A (en) * | 2012-12-07 | 2014-06-11 | 梁福功 | Feed additive |
| CN103892049B (en) * | 2014-04-02 | 2018-10-16 | 北京康华远景科技股份有限公司 | A kind of plant feed additive and preparation method preventing diarrhea of pigs |
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