CN110279033A - A kind of lupulus extract feed addictive and preparation method thereof - Google Patents

A kind of lupulus extract feed addictive and preparation method thereof Download PDF

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Publication number
CN110279033A
CN110279033A CN201910708266.4A CN201910708266A CN110279033A CN 110279033 A CN110279033 A CN 110279033A CN 201910708266 A CN201910708266 A CN 201910708266A CN 110279033 A CN110279033 A CN 110279033A
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China
Prior art keywords
hops
lupulus extract
feed addictive
lupulus
acid
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CN201910708266.4A
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Inventor
段海涛
吴宁鹏
张盼盼
董晓盈
张磊
孟蕾
杨洁
袁聪
赵逢冰
吴志明
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Henan Veterinary Drug And Feed Supervision Institute (henan Animal Product Quality Monitoring And Inspection Center)
Henan University of Animal Husbandry and Economy
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Henan Veterinary Drug And Feed Supervision Institute (henan Animal Product Quality Monitoring And Inspection Center)
Henan University of Animal Husbandry and Economy
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Priority to CN201910708266.4A priority Critical patent/CN110279033A/en
Publication of CN110279033A publication Critical patent/CN110279033A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87—Re-use of by-products of food processing for fodder production

Abstract

The present invention discloses a kind of lupulus extract feed addictive and preparation method thereof, is prepared from the following parts by weight of the components: lupulus extract 20 ~ 50, licorice powder 20 ~ 30, maize cob meal 20 ~ 60.Compared with the existing technology, advantages of the present invention is as follows: 1. use supercritical carbon dioxide extracting, the penetrating odor of hops can be effectively removed, its effective component can be retained to the maximum extent simultaneously, wherein β acid and α acid are main active substances in lupulus extract, Radix Glycyrrhizae has reconciliation effect, can be improved hops effect with lupulus extract compatibility；2. feedstuff additive product form of the invention is solid, convenient for preservation, transports, adds the advantages that facilitating；3. product of the present invention can improve body health situation, improve immunity of organisms, reduce feedstuff-meat ratio, it is of great significance to the development of animal husbandry, facilitate the arriving in " subtracting anti-, nonreactive " epoch, meanwhile the application range of hops has been widened, there is no less important meaning to the sound development of hops plantation industry.

Description

A kind of lupulus extract feed addictive and preparation method thereof
Technical field
The invention belongs to field of feed additive technology, in particular to a kind of lupulus extract feed addictive and its system Preparation Method.
Background technique
Hops, scientific name are Humulus Lupulus L, alternatively referred to as name Flos lupuli, hops, cordateleaf European hop flower, hops, yeast Flower, Tang's showy flowers of herbaceous plants, lupulus etc. are dioecious voluble herb plant.Hops be mainly distributed on 35 °~55 ° of north and south latitude it Between, it mainly abounds with Britain, Denmark, Ireland, France in Europe, U.S. of Turkey in Asia, China and North America these Area.There are the cultivation of hops in North China, northeast, the Northwest in China, and in the Northwest, hops is mainly distributed on Xinjiang The 95 of China's total output is accounted for the hops yield of the Hexi Corridor in Gansu, the two areas.
Hops is one of essential important source material of brewing industry, indispensable in brewing and can not replace Generation.She imparts the soft graceful fragrance of beer and tasty and refreshing slight bitter taste, and Chinese Xinjiang, two province of Gansu are optimums in the world Plant one of the region of hops.By the development more than 30 years, Xinjiang, two provinces and regions of Gansu have become the main hops of China Production base, while being also its important industrial crops.The annual hops total output of China is at 1.2 ~ 1.3 ten thousand tons at present.
Hops development and application values with higher, such as: 1. antibacterial: lupulones and humulus grass ketone in hops Closing object has good bacteriostasis, particularly evident especially for the fungistatic effect of G+ and tulase；2. anti-oxidant: research table Bright, cancer, aging or Other diseases are mostly relevant with the generation of excessive free radicals, there is main antioxidant in hops Hop polyphenols class, Flavonoid substances, alpha-acid, β-acid etc., can oxygen radical effectively in removing machine body；3. improving immunity of organisms: Hops β acid can directly affect enteric microorganism, and then influence the anti-inflammatory properties of host's enterocyte and immune system, beer Flower extract is to chronic gastric mucosa damage, indocin caused by acute gastric mucosal lesion caused by rat dehydrated alcohol, glacial acetic acid Rat pipe film injury is caused, has good inhibiting effect, and have auxiliary protection function to gastric mucosa damage.4. improving nutrients Matter digestive utilization ratio: the side chain of hops β acid has similar structure with oxidation product, can be proliferated with peroxide activator enzyme Activated receptor (PPAR α), and then influence lipid-metabolism.
Radix Glycyrrhizae is leguminous plant Glycyrrhiza Uralensis Glycyrrhiza uralensis Fisch., glycyrrhiza glabra The drying root and rhizome of Glycyrrhiza glabraL. or swollen fruit Radix Glycyrrhiza inflata Bat., main source In the Inner Mongol, Gansu, Xinjiang and other places, there is tonifying Qi, removing toxic substances, eliminating the phlegm, cough-relieving, heat-clearing, analgesic and other effects.Radix Glycyrrhizae has " Xie Baicao The function of poison ", often plays removing toxic substances, coordinating the drug actions of a prescription in prescription, application value include: it is 1. anti-oxidant, antioxidant activity is big Mostly phenolic aldehyde substance plays a major role, and research finds licorice (glycyrrhigin, gl) and its metabolin 18- enoxolone (glycyrrhetinic acid, GA) be all mitochondrial permeability transformation, active oxygen generate and sub-micron concentration under cytochromes Effective inhibitor of c release, GA has the characteristic for promoting apoptosis, and GA is the apoptosis of bile acid induction and effective inhibition of necrosis Agent, the mode of action are consistent with its antioxidation；2. antitumor, Radix Glycyrrhizae can be by influencing tumour cell signal transduction, luring It leads tumor cell differentiation and apoptosis, regulation related enzyme activity and tumour cell cycle, inhibit the number of ways such as tumor cell proliferation Antitumor, research finds that enoxolone can be invaded by inducing apoptosis of tumour cell, suppression of cell period, inhibition tumour cell It attacks, induces tumor cell differentiation, the approach such as tumor multi-medicine drug-resistant is inhibited to play antitumaous effect, and work can be cooperateed with chemotherapeutics With the canceration induced for carcinogenic promoting agent also shows certain inhibition function；3. anti-inflammatory, inflammation is regulated and controled by cytokine profiles, Including inflammatory cytokine and proinflammatory cytokine, the balance between inflammatory cytokine is to maintain body normal immunological and physiology Movable key factor, Radix Glycyrrhizae can stablize the balance between each factor, promote to restore body normal condition, to keep body steady State；4. improving immunity of organisms, the ingredients such as volatile oil, alkaloid, acid, polysaccharide, flavones and saponin in licorice are in machine Certain effect is all shown in body immunological regulation.In vivo and the Clinical Report beneficial effect of Radix Glycyrrhizae and glycyrrhizic acid, it wraps Include antiulcer, the reaction of antiviral and Liver protection.
Currently, with " subtracting anti-", the arriving in " nonreactive " epoch, find antibiotic substitute products, production is natural, safely, subtract it is anti- Livestock products, have important practical significance for sustainable development of animal husbandry.It is answered currently, hops has correlative study For in feed formula, application form to be often pulverised form, causes feed that there is penetrating odor, cause under livestock and poultry feed intake Drop.
Summary of the invention
To solve the above problems, the present invention provides a kind of lupulus extract feed addictive and preparation method thereof.
The object of the present invention is achieved in the following manner:
A kind of lupulus extract feed addictive, is prepared from the following parts by weight of the components: lupulus extract 20 ~ 50, Licorice powder 20 ~ 30, maize cob meal 20 ~ 60.
Preferably, the granularity of the licorice powder and maize cob meal is 400 ~ 500 μm.
The preparation method of the lupulus extract feed addictive, comprising the following steps:
(1) hops is crushed through pulverizer, is sieved, is then placed in extraction kettle；
(2) from CO2CO is flowed out in steel cylinder2Gas, CO2Gas is cooled to liquid through liquefier, by CO2Liquid is through high-pressure metering pump 15 ~ 30 MPa are forced into, then heated device is heated to 35 ~ 50 DEG C, then make it into extraction kettle and hops powder is carried out Extraction, extraction time are 2 ~ 4 h, CO2Flow velocity is 25 ~ 30 L/h, obtains the CO dissolved with hops active constituent2Liquid；
(3) dissolved with the CO of hops active constituent2Liquid enters separator through pressure reducing valve and is separated, and hops activity is precipitated Ingredient to get arrive lupulus extract paste；
(4) above-mentioned lupulus extract mixed in proportion with licorice powder, maize cob meal, stirred to get solid-state beer is arrived Flower extract feed addictive.
Hops in the step (1) is hop pellet or dry beer hops.
Crushing in the step (1) refers to that it is 400 ~ 500 μm that hops, which is crushed to granularity,.
Separator in the step (3) is made of the first separating still and the second separating still, the pressure in the first separating still Power is 5 ~ 20 MPa, and temperature is 30 ~ 45 DEG C；Pressure in second separating still is 3 ~ 10 MPa, and temperature is 20 ~ 35 DEG C.
In mixed process in the step (4), the mixture homogeneity coefficient of variation is not higher than 3.
Compared with the existing technology, advantages of the present invention is as follows:
1. using supercritical carbon dioxide extracting, the penetrating odor of hops can be effectively removed, while can protect to the maximum extent Its effective component is stayed, wherein β acid and α acid are main active substances in lupulus extract, and Radix Glycyrrhizae has reconciliation effect, with beer Flower extract compatibility can be improved hops effect；
2. feedstuff additive product form of the invention is solid, convenient for preservation, transports, adds the advantages that facilitating；
3. product of the present invention can improve body health situation, immunity of organisms is improved, reduces feedstuff-meat ratio, the development to animal husbandry It is of great significance, facilitates the arriving in " subtracting anti-, nonreactive " epoch, meanwhile, the application range of hops is widened, to hops The sound development of plantation industry has no less important meaning.
Specific embodiment
A kind of lupulus extract feed addictive, is prepared from the following parts by weight of the components: lupulus extract 20 ~ 50, licorice powder 20 ~ 30, maize cob meal 20 ~ 60.
Preferably, the granularity of the licorice powder and maize cob meal is 400 ~ 500 μm.
The preparation method of the lupulus extract feed addictive, comprising the following steps:
(1) hops is crushed through pulverizer, is sieved, is then placed in extraction kettle；The sieve aperture being wherein sieved can be 2.0 mm；
(2) from CO2CO is flowed out in steel cylinder2Gas, CO2Gas is cooled to liquid through liquefier, by CO2Liquid is through high-pressure metering pump 15 ~ 30 MPa are forced into, then heated device is heated to 35 ~ 50 DEG C, then make it into extraction kettle and hops powder is carried out Extraction, extraction time are 2 ~ 4 h, CO2Flow velocity is 25 ~ 30 L/h, obtains the CO dissolved with hops active constituent2Liquid；
(3) dissolved with the CO of hops active constituent2Liquid enters separator through pressure reducing valve and is separated, and hops activity is precipitated Ingredient to get arrive lupulus extract paste；
(4) above-mentioned lupulus extract mixed in proportion with licorice powder, maize cob meal, stirred to get solid-state beer is arrived Flower extract feed addictive.
Preferably, the hops in the step (1) is hop pellet or dry beer hops.
Further, the crushing in the step (1) refers to that it is 400 ~ 500 μm that hops, which is crushed to granularity,.
Further, the separator in the step (3) is made of the first separating still and the second separating still, the first separation Pressure in kettle is 5 ~ 20 MPa, and temperature is 30 ~ 45 DEG C；Pressure in second separating still is 3 ~ 10 MPa, and temperature is 20 ~ 35 ℃。
Preferably, in the mixed process in the step (4), the mixture homogeneity coefficient of variation is not higher than 3.
The present invention will be further described combined with specific embodiments below, but not as limitation of the present invention:
Embodiment 1
By particle hops after crushing, sieving obtains hops powder, and granularity is 400 ~ 500 μm, it is effectively living after measured Property ingredient and content are as follows: alpha-acid 5.21, β-acid 6.75；5.00 g of hops powder is accurately weighed, is placed in extraction kettle, from CO2 CO2 gas, CO are flowed out in steel cylinder2Gas is cooled to liquid through liquefier；By CO2Liquid is forced into 25 MPa through high-pressure metering pump； By CO2Heated device is heated to 45 DEG C；Liquid CO2It is extracted in into extraction kettle, extraction time is 3 h, CO2Flow velocity is 27 L/h；Dissolved with the CO of hops active constituent2Enter separator through pressure reducing valve to be separated, wherein separator is by first point It is formed from kettle and the second separating still, the pressure in the first separating still is 15Mpa, and temperature is 40 DEG C；Pressure in second separating still For 6 MPa, temperature is 30 DEG C, and hops active constituent is precipitated, and obtains lupulus extract, and measurement obtains alpha-acid content and is 30.96, β-acid contents are 38.24.Then lupulus extract 1g mixed with 1 g of licorice powder, 3 g of maize cob meal, stirred, The granularity of middle licorice powder and maize cob meal is 400 ~ 500 μm, obtains hops feed addictive.
Embodiment 2
By particle hops after crushing, sieving obtains hops powder, and granularity is 400 ~ 500 μm, it is effectively living after measured Property ingredient and content are as follows: alpha-acid 5.21, β-acid 6.75；5.00 g of hops powder is accurately weighed, is placed in extraction kettle, from CO2 CO is flowed out in steel cylinder2Gas, CO2Gas is cooled to liquid through liquefier；By CO2Liquid is forced into 15 MPa through high-pressure metering pump； By CO2Heated device is heated to 35 DEG C；Liquid CO2It is extracted in into extraction kettle, extraction time is 2 h, CO2Flow velocity is 25 L/h；Dissolved with the CO of hops active constituent2Enter separator through pressure reducing valve to be separated, wherein separator is by first point It is formed from kettle and the second separating still, the pressure in the first separating still is 5 MPa, and temperature is 30 DEG C；Pressure in second separating still For 3Mpa, temperature is 20 DEG C, and hops active constituent is precipitated, and obtains lupulus extract, and measurement obtains alpha-acid content and is 21.18, β-acid contents are 19.11.Then lupulus extract 1g mixed with 1 g of licorice powder, 1.33 g of maize cob meal, stirred It mixes, wherein the granularity of licorice powder and maize cob meal is 400 ~ 500 μm, obtains hops feed addictive.
Embodiment 3
By particle hops after crushing, sieving obtains hops powder, and granularity is 400 ~ 500 μm, it is effectively living after measured Property ingredient and content are as follows: alpha-acid 5.21, β-acid 6.75；5.00 g of hops powder is accurately weighed, is placed in extraction kettle, from CO2 CO is flowed out in steel cylinder2Gas, CO2Gas is cooled to liquid through liquefier；By CO2Liquid is forced into 30 MPa through high-pressure metering pump； By CO2Heated device is heated to 50 DEG C；Liquid CO2It is extracted in into extraction kettle, extraction time is 4 h, CO2Flow velocity is 30 L/h；Dissolved with the CO of hops active constituent2Enter separator through pressure reducing valve to be separated, wherein separator is by first point It is formed from kettle and the second separating still, the pressure in the first separating still is 20 MPa, and temperature is 45 DEG C；Pressure in second separating still For 10 MPa, temperature is 35 DEG C, and hops active constituent is precipitated, and obtains lupulus extract, and measurement obtains alpha-acid content and is 29.89, β-acid contents are 37.14.Then lupulus extract 1g mixed with 0.5 g of licorice powder, maize cob meal 0.5g, stirred It mixes, wherein the granularity of licorice powder and maize cob meal is 400 ~ 500 μm, obtains hops feed addictive.
Embodiment 4
By particle hops after crushing, sieving obtains hops powder, and granularity is 400 ~ 500 μm, it is effectively living after measured Property ingredient and content are as follows: alpha-acid 5.21, β-acid 6.75；5.00 g of hops powder is accurately weighed, is placed in extraction kettle, from CO2 CO2 gas, CO are flowed out in steel cylinder2Gas is cooled to liquid through liquefier；By CO2Liquid is forced into 20 MPa through high-pressure metering pump； By CO2Heated device is heated to 45 DEG C；Liquid CO2It is extracted in into extraction kettle, extraction time 4h, CO2Flow velocity is 29 L/h；Dissolved with the CO of hops active constituent2Enter separator through pressure reducing valve to be separated, wherein separator is by first point It is formed from kettle and the second separating still, the pressure in the first separating still is 20 MPa, and temperature is 30 DEG C；Pressure in second separating still For 10 MPa, temperature is 35 DEG C, and hops active constituent is precipitated, and obtains lupulus extract, and measurement obtains alpha-acid content and is 30.96, β-acid contents are 38.24.Then lupulus extract 1g mixed with licorice powder 0.6g, maize cob meal 0.4g, stirred, Wherein the granularity of licorice powder and maize cob meal is 400 ~ 500 μm, obtains hops feed addictive.
Embodiment 5
By particle hops after crushing, sieving obtains hops powder, and granularity is 400 ~ 500 μm, it is effectively living after measured Property ingredient and content are as follows: alpha-acid 5.21, β-acid 6.75；5.00 g of hops powder is accurately weighed, is placed in extraction kettle, from CO2 CO2 gas, CO are flowed out in steel cylinder2Gas is cooled to liquid through liquefier；By CO2Liquid is forced into 15 MPa through high-pressure metering pump； By CO2Heated device is heated to 50 DEG C；Liquid CO2It is extracted in into extraction kettle, extraction time is 2 h, CO2Flow velocity is 25 L/h；Dissolved with the CO of hops active constituent2Enter separator through pressure reducing valve to be separated, wherein separator is by first point It is formed from kettle and the second separating still, the pressure in the first separating still is 5 MPa, and temperature is 45 DEG C；Pressure in second separating still For 3Mpa, temperature is 35 DEG C, and hops active constituent is precipitated, and obtains lupulus extract, and measurement obtains alpha-acid content and is 30.96, β-acid contents are 38.24.Then lupulus extract 1g mixed with 0.5 g of licorice powder, 1 g of maize cob meal, stirred, Wherein the granularity of licorice powder and maize cob meal is 400 ~ 500 μm, obtains hops feed addictive.
Embodiment 6
By particle hops after crushing, sieving obtains hops powder, and granularity is 400 ~ 500 μm, it is effectively living after measured Property ingredient and content are as follows: alpha-acid 5.21, β-acid 6.75；5.00 g of hops powder is accurately weighed, is placed in extraction kettle, from CO2 CO2 gas, CO are flowed out in steel cylinder2Gas is cooled to liquid through liquefier；By CO2Liquid is forced into 25 MPa through high-pressure metering pump； By CO2Heated device is heated to 45 DEG C；Liquid CO2It is extracted in into extraction kettle, extraction time is 3 h, CO2Flow velocity is 30 L/h；Dissolved with the CO of hops active constituent2Enter separator through pressure reducing valve to be separated, wherein separator is by first point It is formed from kettle and the second separating still, the pressure in the first separating still is 20 MPa, and temperature is 30 DEG C；Pressure in second separating still For 3 MPa, temperature is 35 DEG C, and hops active constituent is precipitated, and obtains lupulus extract, and measurement obtains alpha-acid content and is 30.96, β-acid contents are 38.24.Then lupulus extract 1g mixed with 1 g of licorice powder, 3 g of maize cob meal, stirred, The granularity of middle licorice powder and maize cob meal is 400 ~ 500 μm, obtains hops feed addictive.
Embodiment 7
By particle hops after crushing, sieving obtains hops powder, and granularity is 400 ~ 500 μm, it is effectively living after measured Property ingredient and content are as follows: alpha-acid 5.21, β-acid 6.75；500 g of hops powder is accurately weighed, the extraction kettle of 1000 L is placed in In, from CO2CO is flowed out in steel cylinder2Gas, CO2Gas is cooled to liquid through liquefier；By CO2Liquid pressurizes through high-pressure metering pump To 25 MPa；By CO2Heated device is heated to 45 DEG C；Liquid CO2It is extracted in into extraction kettle, extraction time is 3 h, CO2 Flow velocity is 27 L/h；Dissolved with the CO of hops active constituent2Enter separator through pressure reducing valve to be separated, wherein separation dress It sets and is made of the first separating still and the second separating still, the pressure in the first separating still is 15Mpa, and temperature is 40 DEG C；Second separation Pressure in kettle is 6 MPa, and temperature is 30 DEG C, and hops active constituent is precipitated, obtains about 100 g of lupulus extract, measures It is 36.84% that obtain alpha-acid content, which be 31.22%, β-acid content,.Then by lupulus extract 100g and 100 g of licorice powder, jade The 300 g mixing of rice core powder, stirring, wherein the granularity of licorice powder and maize cob meal is 400 ~ 500 μm, obtains hops feed and adds Add 500 g of agent.
Embodiment 8
By particle hops after crushing, sieving obtains hops powder, and granularity is 400 ~ 500 μm, it is effectively living after measured Property ingredient and content are as follows: alpha-acid 5.21, β-acid 6.75；600 g of hops powder is accurately weighed, the extraction kettle of 1000 L is placed in In, from CO2CO is flowed out in steel cylinder2Gas, CO2Gas is cooled to liquid through liquefier；By CO2Liquid pressurizes through high-pressure metering pump To 25 MPa；By CO2Heated device is heated to 45 DEG C；Liquid CO2It is extracted in into extraction kettle, extraction time is 3 h, CO2 Flow velocity is 27 L/h；Dissolved with the CO of hops active constituent2Enter separator through pressure reducing valve to be separated, wherein separation dress It sets and is made of the first separating still and the second separating still, the pressure in the first separating still is 15Mpa, and temperature is 40 DEG C；Second separation Pressure in kettle is 6 MPa, and temperature is 30 DEG C, and hops active constituent is precipitated, obtains about 120 g of lupulus extract, measures It is 37.91% that obtain alpha-acid content, which be 30.66%, β-acid content,.Then by lupulus extract 120g and 120 g of licorice powder, jade The 360 g mixing of rice core powder, stirring, wherein the granularity of licorice powder and maize cob meal is 400 ~ 500 μm, obtains hops feed and adds Add 600 g of agent.
In order to prove effect of the invention, feeding effect comparative test is now carried out by taking the product of embodiment 1 as an example, and be arranged Control group, specific as follows:
One, using weanling pig as subjects:
1. control group and test group is arranged
Control group 1: blank control does not add antibiotic and other antibiotic substitute products for basic daily ration.
Control group 2: antibiotic is added on basal diet.
Test group: the product of embodiment 1 is added on basal diet.
2. experimental design:
Test pig is Du's x long x Dasanyuan, and original body mass is (9.54 ± 0.08 kg), totally 72, is divided into 3 big groups, respectively pair According to group and test group, it is divided into 3 small component other places reason again per the test pig organized greatly, 3 groups are as repetitive test to be put down Mean value, every group pig 8, growth period raise about 6 weeks, and control group 1 feeds basal diet, and basal diet formula is shown in Table 1, control group 2 feeding basal diets add antibiotic feed, and the additive amount of antibiotic aureomycin is 70 mg/kg, and test group feeds basal diet Hops is added to add agent feedstuff, the additive amount of hops additive is 200 mg/kg, calculates growth performance after the test.Examination Testing place is in Henan Province's Hebi City farm.
1 basal diet formula of table
Raw material Content (%)
Corn 60
Dregs of beans 20
Expanded soybean 8
Whey powder 2
Soya-bean oil 3
Fish meal 3
Premix 4
It is total 100
Note: premix is every kilogram of feed total amount addition: 65 000 IU of vitamin A, vitamin D337 500 IU, vitamin E 450mg, vitamin K315 mg, vitamin B124.2 mg, vitamin B7 3 mg, vitamin B636.2 mg, folic acid 7.5 Mg, 250 mg of pantothenic acid, 3.5 mg of biotin 5.0 mg, Fe 2.5 g, Cu 1.5 g, Zn 2.5 g, Mn 0.75g, I, Se 5.0 mg.
2 control group of table and the growth performance of test group compare
Stage Control group 1 Control group 2 Test group
Original body mass g 9575.76±109.25 9581.36±121.74 9590.91±204.96
End weight g 18764.1±96.52 18797±100.82 18944.73±643.36
Average daily gain g 681.62±0.11a 572.68±0.62b 541.59±0.21b
Average daily gain g 218.77±1.11 219.42±2.64 222.71±14.13
Feedstuff-meat ratio 3.12±0.05a 2.61±0.21b 2.44±0.10b
Note: colleague data subscript difference represent have significant difference (p< 0.05).
It, can by the Growth Performance of Weaning Piglets result in table 2 it is found that adding lupulus extract in test group basal diet Significant decrease feedstuff-meat ratio (p< 0.05), feedstuff-meat ratio and antibiotic addition control group 2 without significant difference (p> 0.05), show beer Flower extract additive can improve growth of animals or poultry performance, substitute antibiotics.
Two, using broiler chicken as subjects:
1. control group and test group is arranged
Control group 1: blank control does not add antibiotic and other antibiotic substitute products for basic daily ration.
Control group 2: antibiotic is added on basal diet.
Test group: the product of embodiment 1 is added on basal diet.
2. experimental design
Test chicken growth cycle is divided into the front and back phase, and original body mass is (0.90 ± 0.06 kg), is divided into 3 processing, each processing 6 A repetition, 18 chickens of each repetition, are raised 6 weeks totally by 324, and control group 1 feeds basal diet, and basal diet formula is shown in Table 3, The feeding addition antibiotic feed of control group 2, additive amount are 25 mg/kg aureomycin, and test group feeding basal diet adds hops to add Add agent feedstuff, additive amount is 200 mg/kg, calculates growth performance after the test, growth performance is shown in Table 4.Test site is In Hebi City farm, Henan Province.
3 basal diet formula of table
Raw material 1~21 d 22~42 d
Corn (%) 53.37 59.16
Dregs of beans (%) 36.31 29.54
Soybean oil (%) 3.02 4.00
Corn protein powder (%) 3.00 3.00
Salt (%) 0.3 0.3
Premix (%) 4 4
It is total 100 100
Note: during 1 ~ 21 age in days, premix is every kilogram of diet total amount addition: 10 000 IU of vitamin A, vitamin D3 1 000 IU, 20 IU of vitamin E, vitamin K30.5 mg, vitamin B12.0 mg, vitamin B28.0 mg, pantothenic acid 10.0 Mg, 35.0 mg of niacin, vitamin B63.5 mg, 0.05 mg of biotin, 0.55 mg of folic acid, vitamin B12 0.01 mg。Fe 2.5 g, Cu 1.5 g, Zn 2.5 g, Mn 0.75g,I 3.5 mg, Se 5.0 mg；
During 22 ~ 42 ages in days, premix is every kilogram of diet total amount addition: 8 000 IU of vitamin A, vitamin D3 750 IU, 15 IU of vitamin E, vitamin K30.5 mg, vitamin B12.0 mg, vitamin B28.0 mg, 10.0 mg of pantothenic acid, 30.0 mg of niacin, vitamin B63.5 mg, 0.05 mg of biotin, 0.55 mg of folic acid, vitamin B12 0.01 mg。Fe 2.5 g, Cu 1.5 g, Zn 2.5 g,Mn 0.75g,I 3.5 mg, Se 5.0 mg。
41 ~ 42 Day-old Broiler Chickens growth performance of table
Project Control group 1 Control group 2 Test group
End weight kg 2.44±0.07a 2.53±0.08b 2.54±0.04b
Average daily gain g 104.26±0.83a 107.26±0.32b 108.30±1.39b
Average daily gain g 58.38±1.63a 60.11±1.38b 60.87±1.33b
Feedstuff-meat ratio 1.79±0.04 1.78±0.02 1.78±0.04
Note: colleague data subscript difference represent have significant difference (p< 0.05).
By the meat chicken growth performance result of table 4 it is found that test group end is significantly higher than control group 1(againp< 0.05), and it compares 2 differences of group it is not significant (p> 0.05), the average daily gain of test group and average daily gain are significantly higher than control group 1(p< 0.05), with 2 difference of control group it is not significant (p> 0.05), show that lupulus extract is added in basal diet can improve broiler chicken life Weight, alternative antibiotic usage are delivered in long performance, raising for sale.
What has been described above is only a preferred embodiment of the present invention, it is noted that for those skilled in the art, Without depart from that overall concept of the invention, several changes and improvements can also be made, these also should be considered as of the invention Protection scope, these all will not influence the effect and patent practicability that the present invention is implemented.

Claims (7)

1. a kind of lupulus extract feed addictive, it is characterised in that: be prepared from the following parts by weight of the components: hops Extract 20 ~ 50, licorice powder 20 ~ 30, maize cob meal 20 ~ 60.
2. lupulus extract feed addictive as described in claim 1, it is characterised in that: the licorice powder and maize cob meal Granularity be 400 ~ 500 μm.
3. the preparation method of lupulus extract feed addictive as claimed in claim 1 or 2, it is characterised in that: including with Lower step:
(1) hops is crushed through pulverizer, is sieved, is then placed in extraction kettle；
(2) from CO2CO is flowed out in steel cylinder2Gas, CO2Gas is cooled to liquid through liquefier, by CO2Liquid adds through high-pressure metering pump 15 ~ 30 MPa are depressed into, then heated device is heated to 35 ~ 50 DEG C, then make it into extraction kettle and hops powder is extracted It takes, extraction time is 2 ~ 4 h, CO2Flow velocity is 25 ~ 30 L/h, obtains the CO dissolved with hops active constituent2Liquid；
(3) dissolved with the CO of hops active constituent2Liquid enters separator through pressure reducing valve and is separated, and hops activity is precipitated Ingredient to get arrive lupulus extract paste；
(4) above-mentioned lupulus extract mixed in proportion with licorice powder, maize cob meal, stirred to get solid-state beer is arrived Flower extract feed addictive.
4. the preparation method of lupulus extract feed addictive as claimed in claim 3, it is characterised in that: the step (1) hops in is hop pellet or dry beer hops.
5. the preparation method of lupulus extract feed addictive as claimed in claim 3, it is characterised in that: the step (1) crushing in refers to that it is 400 ~ 500 μm that hops, which is crushed to granularity,.
6. the preparation method of lupulus extract feed addictive as claimed in claim 3, it is characterised in that: the step (3) separator in is made of the first separating still and the second separating still, and the pressure in the first separating still is 5 ~ 20 MPa, temperature It is 30 ~ 45 DEG C；Pressure in second separating still is 3 ~ 10 MPa, and temperature is 20 ~ 35 DEG C.
7. the preparation method of lupulus extract feed addictive as claimed in claim 3, it is characterised in that: the step (4) in the mixed process in, the mixture homogeneity coefficient of variation is not higher than 3.
CN201910708266.4A 2019-08-01 2019-08-01 A kind of lupulus extract feed addictive and preparation method thereof Pending CN110279033A (en)

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CN111642632A (en) * 2020-07-21 2020-09-11 山西农业大学 Functional additive for livestock feed and preparation method thereof
CN112106900A (en) * 2020-08-31 2020-12-22 河南牧业经济学院 Feed for improving egg laying performance and oviduct development of laying hens and preparation method thereof
WO2023057556A1 (en) 2021-10-07 2023-04-13 Dr. Eckel Vermögensverwaltung Gmbh Composition for reducing the concentration of viruses and of african swine fever virus (asfv) in animal feed and litter materials for stables
EP4176730A1 (en) 2021-10-07 2023-05-10 Dr. Eckel Vermögensverwaltung GmbH Composition for reducing the concentration of viruses and african swine fever virus (asfv) in animal feed and material for spreading in stalls

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111642632A (en) * 2020-07-21 2020-09-11 山西农业大学 Functional additive for livestock feed and preparation method thereof
CN112106900A (en) * 2020-08-31 2020-12-22 河南牧业经济学院 Feed for improving egg laying performance and oviduct development of laying hens and preparation method thereof
CN112106900B (en) * 2020-08-31 2023-07-25 河南牧业经济学院 Feed for improving egg laying performance and oviduct development of laying hens and preparation method thereof
WO2023057556A1 (en) 2021-10-07 2023-04-13 Dr. Eckel Vermögensverwaltung Gmbh Composition for reducing the concentration of viruses and of african swine fever virus (asfv) in animal feed and litter materials for stables
EP4176730A1 (en) 2021-10-07 2023-05-10 Dr. Eckel Vermögensverwaltung GmbH Composition for reducing the concentration of viruses and african swine fever virus (asfv) in animal feed and material for spreading in stalls

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