CN107410694A - A kind of feed addictive of tranquilizing and allaying excitement, its preparation method and application - Google Patents
A kind of feed addictive of tranquilizing and allaying excitement, its preparation method and application Download PDFInfo
- Publication number
- CN107410694A CN107410694A CN201710507629.9A CN201710507629A CN107410694A CN 107410694 A CN107410694 A CN 107410694A CN 201710507629 A CN201710507629 A CN 201710507629A CN 107410694 A CN107410694 A CN 107410694A
- Authority
- CN
- China
- Prior art keywords
- parts
- tranquilizing
- allaying excitement
- feed addictive
- gastrodin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002936 tranquilizing effect Effects 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 18
- PUQSUZTXKPLAPR-KSSYENDESA-N 4-(beta-D-Glucopyranosyloxy) benzyl alcohol Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1)c1ccc(CO)cc1 PUQSUZTXKPLAPR-KSSYENDESA-N 0.000 claims abstract description 17
- PUQSUZTXKPLAPR-UJPOAAIJSA-N Gastrodin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(CO)C=C1 PUQSUZTXKPLAPR-UJPOAAIJSA-N 0.000 claims abstract description 17
- 229930193974 gastrodin Natural products 0.000 claims abstract description 17
- PUQSUZTXKPLAPR-NZEXEKPDSA-N helicidol Natural products O([C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](CO)O1)c1ccc(CO)cc1 PUQSUZTXKPLAPR-NZEXEKPDSA-N 0.000 claims abstract description 17
- 235000008694 Humulus lupulus Nutrition 0.000 claims abstract description 15
- 241000208688 Eucommia Species 0.000 claims abstract description 14
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000004471 Glycine Substances 0.000 claims abstract description 9
- 239000003814 drug Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 230000037396 body weight Effects 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 244000144977 poultry Species 0.000 claims description 5
- 238000013019 agitation Methods 0.000 claims description 3
- -1 distillate Chemical compound 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000009395 breeding Methods 0.000 claims description 2
- 230000001488 breeding effect Effects 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 abstract description 25
- 239000000654 additive Substances 0.000 abstract description 22
- 241000287828 Gallus gallus Species 0.000 abstract description 12
- 238000005516 engineering process Methods 0.000 abstract description 4
- 230000007423 decrease Effects 0.000 abstract description 3
- 239000003674 animal food additive Substances 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 12
- 239000000243 solution Substances 0.000 description 7
- 210000001835 viscera Anatomy 0.000 description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 241000271566 Aves Species 0.000 description 4
- 235000013330 chicken meat Nutrition 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 235000013594 poultry meat Nutrition 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 230000002082 anti-convulsion Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 210000000003 hoof Anatomy 0.000 description 3
- 235000013372 meat Nutrition 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 208000016261 weight loss Diseases 0.000 description 3
- 230000004580 weight loss Effects 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 206010039897 Sedation Diseases 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000036280 sedation Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 230000001228 trophic effect Effects 0.000 description 2
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 1
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 235000019743 Choline chloride Nutrition 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- RMFGNMMNUZWCRZ-UHFFFAOYSA-N Humulone Natural products CC(C)CC(=O)C1=C(O)C(O)(CC=C(C)C)C(O)=C(CC=C(C)C)C1=O RMFGNMMNUZWCRZ-UHFFFAOYSA-N 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- OLHLJBVALXTBSQ-UHFFFAOYSA-N Lupulone Natural products CC(C)CC(=O)C1C(=O)C(CC=C(C)C)C(=O)C(CC=C(C)C)(CC=C(C)C)C1=O OLHLJBVALXTBSQ-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003556 anti-epileptic effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- 229960003178 choline chloride Drugs 0.000 description 1
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical group 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229940105684 folic acid 2.5 mg Drugs 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 229940106579 hops extract Drugs 0.000 description 1
- VMSLCPKYRPDHLN-NRFANRHFSA-N humulone Chemical compound CC(C)CC(=O)C1=C(O)C(CC=C(C)C)=C(O)[C@@](O)(CC=C(C)C)C1=O VMSLCPKYRPDHLN-NRFANRHFSA-N 0.000 description 1
- 239000001906 humulus lupulus l. absolute Substances 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- LSDULPZJLTZEFD-UHFFFAOYSA-N lupulone Chemical class CC(C)CC(=O)C1=C(O)C(CC=C(C)C)=C(O)C(CC=C(C)C)(CC=C(C)C)C1=O LSDULPZJLTZEFD-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229940079458 niacinamide 50 mg Drugs 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000002557 soporific effect Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000007666 subchronic toxicity Effects 0.000 description 1
- 231100000195 subchronic toxicity Toxicity 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Environmental Sciences (AREA)
- Botany (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of feed addictive of tranquilizing and allaying excitement, its preparation method and application, belong to field of feed additive technology.Tranquilizing and allaying excitement feed addictive of the present invention, it is prepared by the component of following parts by weight：3~5 parts of vanillic aldehyde, 5~10 parts of glycine, 5~10 parts of Gastrodin, 30~60 parts of hops, 20~40 parts of the bark of eucommia；Preferably, 4 parts of vanillic aldehyde, 7.5 parts of glycine, 7.5 parts of Gastrodin, 45 parts of hops, 30 parts of the bark of eucommia.Laying hen can be reduced using the feed addictive of tranquilizing and allaying excitement of the present invention and turns group due to the usually injured and death rate caused by scaring, improved operating efficiency more than 7%, alleviated 66% laying rate decline；The death rate can be reduced using the additive of the present invention when broiler chicken and pig are delivered for sale, weightlessness is reduced, direct plunges into output ratio more than 1: 5.
Description
Technical field
The invention belongs to field of feed additive technology, and in particular to a kind of feed addictive of tranquilizing and allaying excitement, its preparation
Methods and applications.
Background technology
During its feeding, due to dividing group, turn house, vaccine injection, delivering for sale, transport or butcher, scaring, fear, earn
Prick and cause body injury, dehydration weightless, even dead, economic loss is caused to aquaculture；In addition, the laying hen production after frightened
Egg rate can also decline；When butchering, animal can also promote body to produce toxin due to scaring, so as to reduce the meat quality of livestock and poultry.
Tranquilizing and allaying excitement medicine can reduce the frightening of livestock and poultry, it is frightened and caused by body injury, reduce the death rate and frightened
The laying rate of laying hen afterwards；Traditional tranquilizing and allaying excitement medicine has certain toxic side effect, and is remained in animal body, influences flesh
Meat, the edible meat containing tranquilizing and allaying excitement medicine residual of people, can also harmful effect be produced to body.Therefore, need badly open
It is green safe to send out a kind of, have no toxic side effect, the feed addictive of the tranquilizing and allaying excitement of noresidue substitutes traditional tranquilizing and allaying excitement medicine.
The content of the invention
For problems of the prior art, it is an object of the invention to provide a kind of tranquilizing and allaying excitement, it is anticonvulsion, anti-should
Sharp and green safe, noresidue feed addictive, and the preparation method and application of the additive.
To achieve these goals, technical scheme is as follows：
A kind of feed addictive of tranquilizing and allaying excitement, it is prepared by the component of following parts by weight：It is 3~5 parts of vanillic aldehyde, sweet
5~10 parts of propylhomoserin, 5~10 parts of Gastrodin, 30~60 parts of hops, 20~40 parts of the bark of eucommia.
The feed addictive of the tranquilizing and allaying excitement, it is the component preparation by following parts by weight on the basis of such scheme
Form：4 parts of vanillic aldehyde, 7.5 parts of glycine, 7.5 parts of Gastrodin, 45 parts of hops, 30 parts of the bark of eucommia.
On the basis of such scheme, the preparation method of the feed addictive of the tranquilizing and allaying excitement, step is as follows：
A. the medicine materical crude slice of hops and the bark of eucommia is put into extractor, raw material is mixed with water by 1: 5 weight ratio, is boiled
30min, liquid height for initial 1/2 when, collect distillate, and be transferred to extract solution is filtered in concentration tank；
B. the extract solution in concentration tank is filled into Agitation Tank when carrying out being concentrated under reduced pressure into original 1/2 for 80~90 DEG C,
Glycine, Gastrodin, distillate, vanillic aldehyde are sequentially added while opening and stirring, 20min is finally stirred for and gets product.
On the basis of such scheme, the feed addictive of the tranquilizing and allaying excitement is used to the tranquilizing and allaying excitement of fowl poultry kind and resisted answer
Swash.
A kind of birds tranquilizing and allaying excitement and the method for resisting stress, the feed addictive of tranquilizing and allaying excitement prepared by the above method are converted
Water feeds birds, has been drunk before seizure in 3~5h.
On the basis of such scheme, the usage amount of the feed addictive of the tranquilizing and allaying excitement is：Body weight≤500g/
Birds, only applied according to 0.1g/；The birds of body weight >=1500g/ only, only apply according to 0.2g/.
One breeding class tranquilizing and allaying excitement and the method for resisting stress, the feed addictive of tranquilizing and allaying excitement prepared by the above method are mixed
Enter feed feeding domestic animals, eaten before seizure in 5~7h.
On the basis of such scheme, the usage amount of the feed addictive of the tranquilizing and allaying excitement is：10~20g/ heads.
Beneficial effects of the present invention
Gastrodin in additive of the present invention has calm, anticonvulsion, antioxidation；Hops extract solution is to maincenter god
Through a small amount of calm, the middle amount hypnosis of system, lupulones therein, humulone tool sedation, play a major role；The bark of eucommia is containing Du
Secondary flavones, eucommia bark polycose and chlorogenic acid, have the function that filling liver kidney, strengthening the bones and muscles, hypotensive, extenuate stress, controlling nocturnal emission with astringent drugs it is antiabortive, herein
The effect of tranquilizing soporific can be strengthened with rhizoma Gastrodiae compatibility, helped out；Glycine has certain sedation again, has simultaneously
Prevent plant volatile oil from aoxidizing, the effect to extend the shelf life, also play the role of to supplement amino acid；Vanillic aldehyde has anti-epileptic work
With, and good phagostimulant, can accelerate additive of the present invention eats speed.Five kinds of compatibilities of the above, play it is more preferable it is calm,
It is anticonvulsion, reduce stress effect.
Using the laying hen of additive of the present invention, can reduce due to arrest, turn group etc. stress, scaring cause it is usual injured, dead
More than the 80% of rate is died, and substantially reduces and manually arrests, operation difficulty, improves operating efficiency more than 7%, 66% production can be alleviated
Egg rate declines；Chicken, which is delivered for sale, uses additive of the present invention when transport is butchered, about few weightless 20 gram/chickens, colony can reduce by 60%
The death rate, direct plunge into output ratio more than 1: 5；Pig, which is delivered for sale, uses additive of the present invention when transport is butchered, about few weightlessness
500 grams/head, output ratio is direct plungeed into more than 1: 5.
Embodiment
Used term in the present invention, unless otherwise specified, typically have those of ordinary skill in the art usual
The implication of understanding.
With reference to specific embodiment, and with reference to the data further detailed description present invention.Following examples simply be
Illustrate the present invention, rather than the scope that limit the invention in any way.
Embodiment 1
A kind of feed addictive of tranquilizing and allaying excitement, it is prepared by the component of following parts by weight：3 parts of vanillic aldehyde, sweet ammonia
5 parts of acid, 5 parts of Gastrodin, 30 parts of hops, 20 parts of the bark of eucommia.
Specific preparation method is as follows：
A. the medicine materical crude slice of hops and the bark of eucommia being put into extractor, raw material is mixed with water by 1: 5 weight ratio, boils 30min,
Liquid height for initial 1/2 when, collect distillate, and be transferred to extract solution is filtered in concentration tank；
B. the extract solution in concentration tank is filled into Agitation Tank when carrying out being concentrated under reduced pressure into original 1/2 for 80~90 DEG C,
Glycine, Gastrodin, distillate, vanillic aldehyde are sequentially added while opening and stirring, 20min is finally stirred for and gets product.
The purposes of the feed addictive of the tranquilizing and allaying excitement, it is the calmness for poultry class on the basis of such scheme
Calm the nerves and resisting stress.
Embodiment 2
A kind of feed addictive of tranquilizing and allaying excitement, it is prepared by the component of following parts by weight：4 parts of vanillic aldehyde, sweet ammonia
7.5 parts of acid, 7.5 parts of Gastrodin, 45 parts of hops, 30 parts of the bark of eucommia.
Preparation method is same as Example 1.
Embodiment 3
A kind of feed addictive of tranquilizing and allaying excitement, it is prepared by the component of following parts by weight：5 parts of vanillic aldehyde, sweet ammonia
10 parts of acid, 10 parts of Gastrodin, 60 parts of hops, 40 parts of the bark of eucommia.
Preparation method is same as Example 1.
First, toxicity test
1.1 test method
The ICR mouse 100 that body weight is 18~22g are chosen, after 3 days adaptability is raised, being divided into 4 groups at random, (male and female are each
Half), 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment and blank control group, every group 25；Blank control group gavage physiology salt
Water, 1~3 group of embodiment are gavaged after the feed addictive for the tranquilizing and allaying excitement for preparing each embodiment is dissolved in water；Embodiment 1~3
Group once daily 0.2g/kg, Continuous Observation 24h.
1.2 testing index
1.2.1 the state of mind of viewing test mouse, diet situation, condition of morbidity death is recorded.
1.2.2 the Biochemical Indices In Serum of determination test mouse.
1.2.3 Dissection test mouse, observation internal organs change and determine organ index (organ index=internal organs weight/body weight ×
100)。
1.3 results and analysis
All gathered datas carry out processing early stage using Excel softwares, then carry out statistical analysis, LSD with SPSS20.0
Multiple range test is carried out, is as a result represented using mean+SD.
1.3.1 mouse morbidity and death condition are tested
After administration, test group is more quiet relative to control group mouse, recovers normal after 8h, and diet situation has no obvious different
Often；Mouse falls ill and death condition is as shown in table 1.
The mouse of table 1 falls ill and death condition
| Group | Total (only) | Dead (only) | Death rate % |
| Embodiment 1 | 25 | 0 | 0 |
| Embodiment 2 | 25 | 0 | 0 |
| Embodiment 3 | 25 | 0 | 0 |
| Control group | 25 | 0 | 0 |
1.3.2 the Biochemical Indices In Serum of mouse is tested
After off-test, mouse is slaughtered, takes blood to separate serum, it is as shown in table 2 to determine each biochemical indicator.
Table 2 tests mouse Biochemical Indices In Serum situation
As can be seen from Table 2, mouse Biochemical Indices In Serum is compared without significant difference between each experimental group, shows calmness of the invention
The feed addictive calmed the nerves has no adverse effects to liver function and renal function.
1.3.3 the Viscera index of mouse is tested
After experiment terminates, mouse is slaughtered, dissects and observes internal organ no abnormality seen, weigh each organ weights, and calculate internal organs and refer to
Number is as shown in table 3.
Table 3 tests mouse Viscera index situation
| Group | Liver index | Renal index | Cardiac index | Lungs index | Index and spleen index |
| Embodiment 1 | 54.36±1.49 | 13.12±0.25 | 4.43±0.21 | 6.45±0.52 | 5.12±0.47 |
| Embodiment 2 | 55.05±1.14 | 13.98±0.27 | 4.69±0.19 | 6.91±0.47 | 5.45±0.39 |
| Embodiment 3 | 54.92±1.21 | 13.47±0.21 | 4.57±0.23 | 6.83±0.43 | 5.33±0.42 |
| Control group | 54.07±1.43 | 13.09±0.29 | 4.35±0.17 | 6.36±0.49 | 5.01±0.45 |
As shown in Table 3, between each test group and control group, the Viscera index of mouse is without significant changes.
1.4 subchronic toxicity test
The feed addictive of tranquilizing and allaying excitement prepared by the embodiment of the present invention 2 is by 0.2g/kg once daily ICR mouse, and one
Zhou Hou, the state of mind, diet situation, Biochemical Indices In Serum and the organ index of animal are shown no obvious abnormalities, and each index without
Overt toxicity reacts, and shows no cumulative toxicity.
2nd, the test of pesticide effectiveness
2.1 experiment prescriptions
2.1.1 the additive of embodiment 1, it is designated as 1 group of embodiment；
2.1.2 the additive of embodiment 2, it is designated as 2 groups of embodiment；
2.1.3 the additive of embodiment 3, it is designated as 3 groups of embodiment；
2.1.4 embodiment 1 is free of the additive of hops, is designated as 1 group of control；
2.1.5 embodiment 1 is free of the additive of Gastrodin, is designated as 2 groups of control；
2.1.6 blank control group.
2.1 laying hens turn group
Selection is randomly divided into 6 groups with batch hatching, body weight close (about 1800g), healthy laying hen 600, every group 100,
Before group is turned in 3~5h, every group is only free of beer using the additive of the embodiment of the present invention 1~3, embodiment 1 respectively according to 0.2g/
Colored additive and embodiment 1 are free of the additive of Gastrodin, separately set a blank control group.Other experiment conditions are completely the same.
Record turns the usual injury of each group laying hen after group, the death rate, operating efficiency, the laying rate before and after group of turning.As shown in table 4：
The feed addictive of the tranquilizing and allaying excitement of table 4 turns the influence of group to laying hen
As can be seen from Table 4：When turning group, the tranquilizing and allaying excitement feed prepared using the embodiment of the present invention 1~3 is added laying hen
Agent, all significantly reduced relative to the usual injury rate of blank control group and the death rate, wherein usual injury rate reduces by more than 80%,
The death rate reduces by 100%；Control group 1 and 2 is significantly reduced relative to the usual injury rate and the death rate of blank control, usually by
Hindering rate reduces by more than 60%, and the death rate reduces by 50%；The operating efficiency that 1~3 group of embodiment significantly carries relative to blank control group
High by more than 7%, control group 1,2 improves more than 2% relative to blank control group；1~3 group of laying rate for turning laying hen after group of embodiment
2% is descend below, blank control group declines 6%, and relative to control group, 1~3 group of embodiment is significantly alleviated under 66% laying rate
Drop, the laying rate of control group 1,2 decline 2% and 4% respectively；As can be seen here, the calmness prepared using the embodiment of the present invention 1~3
Feed addictive of calming the nerves contributes to the group that turns of laying hen, and the additive effect of wherein embodiment 2 is optimal.
2.2 broiler chicken are delivered transport for sale and butchered
Selective body heavy phase is near, the broiler chicken to be delivered for sale 600 of health, is randomly divided into 6 groups, every group 100；3 before delivering for sale~
In 5h, every group is only applied the additive of the additive of the embodiment of the present invention 1~3, embodiment 1 without hops respectively according to 0.2g/
The additive of Gastrodin is free of with embodiment 1, separately sets a blank control group.Other experiment conditions are completely the same.Statistics delivers fortune for sale
Defeated the broiler chicken on the hoof death rate, weight-loss ratio and input-output ratio, as shown in table 5：
The feed addictive of the tranquilizing and allaying excitement of table 5 delivers the influence that transport is butchered for sale to broiler chicken
As can be seen from Table 5：When broiler chicken is delivered transport for sale and butchered, added using the tranquilizing and allaying excitement feed of the embodiment of the present invention 1~3
Add agent, significantly the death rate more than 60%, control group 1,2 more than the 30% of the death rate can be reduced relative to blank control group；It is real
The broiler chicken of 1~3 group of example is applied relative to the about few weightless 20g/ chicken of blank control group, control group 1,2 is relative to blank control group
About few weightless 10g/ chicken；The input-output ratio that 1~3 group of embodiment is 1: 5, and the input-output ratio of control group 1,2 is 1: 4；
As can be seen here, contribute to broiler chicken to deliver transport for sale using the tranquilizing and allaying excitement feed addictive of the preparation of the embodiment of the present invention 1~3 to butcher,
The additive effect of wherein embodiment 2 is optimal.
2.3 pigs deliver transport for sale and butchered
Selective body heavy phase is near, the pig to be delivered for sale 480 of health, is randomly divided into 6 groups, every group 80；5~7h before delivering for sale,
Every group is pressed 10~20g/ heads, feeds the additive that hops is free of containing the additive of the embodiment of the present invention 1~3, embodiment 1 respectively
With the feed of additive of the embodiment 1 without Gastrodin, a blank control group is separately set, any additive is not added in feed.Its
His experiment condition is completely the same.Statistics delivers transport the pig on the hoof death rate, weight-loss ratio and input-output ratio for sale.
Feed concrete composition and trophic level are shown in Table 6.
The feed of table 6 forms and trophic level
Note：Premix provides Cu 180mg, Fe 220mg, Mn 55mg, Zn 210mg, I 0.3mg, Se to every kg daily rations
0.3mg, Co 0.3mg, VA 15000IU, VD 33700IU, VE 50IU, VK 4.5mg, VB14mg, VB212mg, VB6
7.5mg, VB1235 μ g, biotin 150 μ g, pantothenic acid 35mg, folic acid 2.5mg, niacinamide 50mg, Choline Chloride 550mg.
It is as shown in table 7 that pig delivers the on the hoof death rate of transport, weight-loss ratio and input-output ratio for sale：
The feed addictive of the tranquilizing and allaying excitement of table 7 delivers the influence that transport is butchered for sale to pig
As can be seen from Table 7：When pig delivers transport for sale and butchered, the tranquilizing and allaying excitement feed of the embodiment of the present invention 1~3 is used to add
Agent, and all control group death rates are 0%, no significant changes；1~3 group of embodiment delivers pig for sale relative to blank control group
About few weightless 500g/ heads pig, control group 1,2 is relative to the about few weightless 380g/ heads pig of blank control group；1~3 group of embodiment
Input-output ratio be 1: 5, the input-output ratio of control group 1,2 is 1: 4；As can be seen here, made using the embodiment of the present invention 1~3
Standby tranquilizing and allaying excitement feed addictive contributes to pig to deliver transport for sale to butcher, and the additive effect of wherein embodiment 2 is optimal.
The above described is only a preferred embodiment of the present invention, being not the limitation for making other forms to the present invention, appoint
What those skilled in the art changed or be modified as possibly also with the technology contents of the disclosure above equivalent variations etc.
Imitate embodiment.But it is every without departing from technical solution of the present invention content, the technical spirit according to the present invention is to above example institute
Any simple modification, equivalent variations and the remodeling made, still fall within the protection domain of technical solution of the present invention.
Claims (8)
- A kind of 1. feed addictive of tranquilizing and allaying excitement, it is characterised in that：It is to be prepared by the component of following parts by weight：Vanillic aldehyde 3~5 parts, 5~10 parts of glycine, 5~10 parts of Gastrodin, 30~60 parts of hops, 20~40 parts of the bark of eucommia.
- 2. the feed addictive of tranquilizing and allaying excitement according to claim 1, it is characterised in that：It is by the component system of following parts by weight It is standby to form：3~5 parts of vanillic aldehyde, 5~10 parts of glycine, 5~10 parts of Gastrodin, 30~60 parts of hops, 20~40 parts of the bark of eucommia.
- 3. the preparation method of the feed addictive of tranquilizing and allaying excitement according to claim 1 or claim 2, it is characterised in that：Step is as follows：A. the medicine materical crude slice of hops and the bark of eucommia is put into extractor, raw material is mixed with water by 1: 5 weight ratio, boils 30min, liquid Body highly for initial 1/2 when, collect distillate, and be transferred to extract solution is filtered in concentration tank；B. the extract solution in concentration tank is filled into Agitation Tank when carrying out being concentrated under reduced pressure into original 1/2 for 80~90 DEG C, is being opened Glycine, Gastrodin, distillate, vanillic aldehyde are sequentially added while opening stirring, 20min is finally stirred for and gets product.
- 4. the purposes of the feed addictive of tranquilizing and allaying excitement according to claim 1 or claim 2, it is characterised in that：For fowl poultry kind Tranquilizing and allaying excitement and resisting stress.
- A kind of 5. method of birds tranquilizing and allaying excitement, it is characterised in that：The feed addictive of tranquilizing and allaying excitement prepared by claim 3 Feeding birds are watered, have been drunk before seizure in 3~5h.
- 6. the method for birds tranquilizing and allaying excitement according to claim 5, it is characterised in that：The feed addictive of the tranquilizing and allaying excitement Usage amount be：The birds of body weight≤500g/ only, only apply according to 0.1g/；The birds of body weight >=1500g/ only, according to 0.2g/ Only apply.
- 7. the method for a breeding class tranquilizing and allaying excitement, it is characterised in that：The feed addictive of tranquilizing and allaying excitement prepared by claim 3 Feed feeding domestic animals are admixed, have been eaten before seizure in 5~7h.
- 8. the method for domestic animals tranquilizing and allaying excitement according to claim 7, it is characterised in that：The feed addictive of the tranquilizing and allaying excitement Usage amount be：10~20g/ heads.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710507629.9A CN107410694A (en) | 2017-06-28 | 2017-06-28 | A kind of feed addictive of tranquilizing and allaying excitement, its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710507629.9A CN107410694A (en) | 2017-06-28 | 2017-06-28 | A kind of feed addictive of tranquilizing and allaying excitement, its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107410694A true CN107410694A (en) | 2017-12-01 |
Family
ID=60427818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710507629.9A Pending CN107410694A (en) | 2017-06-28 | 2017-06-28 | A kind of feed addictive of tranquilizing and allaying excitement, its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107410694A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110279033A (en) * | 2019-08-01 | 2019-09-27 | 河南省兽药饲料监察所(河南省畜产品质量监测检验中心) | A kind of lupulus extract feed addictive and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593188A (en) * | 2004-07-14 | 2005-03-16 | 张家界恒兴生物科技有限公司 | Eucommia feed addictive |
| CN1824139A (en) * | 2005-12-22 | 2006-08-30 | 杨秀庆 | Heat clearing pain settling Chinese medicine |
| CN101011102A (en) * | 2006-10-12 | 2007-08-08 | 玉门拓璞科技开发有限责任公司 | Use of hop slag for preparing animal fodder |
| CN103829038A (en) * | 2014-03-05 | 2014-06-04 | 张家界恒兴生物科技有限公司 | Novel eucommia feed additive and production method thereof |
| CN104431363A (en) * | 2014-12-10 | 2015-03-25 | 张家界恒兴生物科技有限公司 | Special vegetable feed additive for poultry breeding and production method thereof |
-
2017
- 2017-06-28 CN CN201710507629.9A patent/CN107410694A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593188A (en) * | 2004-07-14 | 2005-03-16 | 张家界恒兴生物科技有限公司 | Eucommia feed addictive |
| CN1824139A (en) * | 2005-12-22 | 2006-08-30 | 杨秀庆 | Heat clearing pain settling Chinese medicine |
| CN101011102A (en) * | 2006-10-12 | 2007-08-08 | 玉门拓璞科技开发有限责任公司 | Use of hop slag for preparing animal fodder |
| CN103829038A (en) * | 2014-03-05 | 2014-06-04 | 张家界恒兴生物科技有限公司 | Novel eucommia feed additive and production method thereof |
| CN104431363A (en) * | 2014-12-10 | 2015-03-25 | 张家界恒兴生物科技有限公司 | Special vegetable feed additive for poultry breeding and production method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 葛长荣: "杜仲在养殖业中的应用", 《饲料研究》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110279033A (en) * | 2019-08-01 | 2019-09-27 | 河南省兽药饲料监察所(河南省畜产品质量监测检验中心) | A kind of lupulus extract feed addictive and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Nagaraju et al. | Effect of dietary supplementation of humic acids on performance of broilers | |
| CN104206859B (en) | Antibiotic-free feed for fattening pigs and preparation method thereof | |
| US8460719B1 (en) | Method of using nutritional supplement | |
| JP2542655B2 (en) | Mixed feed for animals | |
| CN107410694A (en) | A kind of feed addictive of tranquilizing and allaying excitement, its preparation method and application | |
| Shinde et al. | Effect of cardamom (Elettaria cardamomum) and Ginger (Zingiber officinale) powder supplementation on growth performance and economic analysis in broiler | |
| NL2000548C1 (en) | Rhodospirillum and Phaeospirillum in animal feed for obtaining food products with a lowered cholesterol level. | |
| EP2817016B1 (en) | Method for improving quality of poultry meat | |
| US20040161449A1 (en) | Formulation and method for reduction of stress in meat-producing animals | |
| Grela et al. | Influence of partial replacement of some inorganic minerals with glycine complex and vitamin D source on performance, slaughter traits, sensory and physico-chemical characteristics of pheasant muscles (L.) depending on gender | |
| AL-Ramamneh | The effect of adding aqueous mint and lemon to heat-stress broiler’s drinking water | |
| Korsakov et al. | The effect of humic acids on the natural resistance of the body of broiler chickens and the quality of their meat | |
| CN112890044A (en) | Feed additive for improving chicken quality and prolonging meat quality preservation period and feeding method | |
| Olaifa et al. | Effect of oral administration of three different phytobiotics on growth performance of locally-adapted turkeys | |
| Gandi et al. | Haematology and serum biochemical indices of broiler chickens fed poultry by-product meal treated with ginger (Zingiber Officinale) | |
| Jha et al. | Evaluation of growth and carcass characteristics of broiler chickens (Cobb 500) feed on different level of organic acids inclusion in diet at Parwanipur | |
| Anothaisinthawee et al. | Carcass and meat quality of three genotype populations in goat breeding for meat purposes in Thailand | |
| CN104522424B (en) | A kind of compound additive and preparation method for improving the public beast breeding capacity of mink | |
| Tagoe | The response of broiler chickens to dietary inclusion of alternanthera sessilis leaf meal (ASLM) | |
| CN109315630A (en) | Before a kind of alleviation butchering fowl fasting stress Antistress agent and preparation method thereof | |
| Bassiony et al. | Effect of some bioactive components of essential oils on growing rabbits performance | |
| RU2816177C1 (en) | Fermented milk probiotic additive for growing poultry for meat and method of its preparation | |
| Öztürk et al. | Effects of dietary organic acids on performance and carcass characteristics and gut flora of broiler chicks | |
| Sapsuha et al. | Butterfly pea (Clitoria ternatea) extract as a potential feed additive for broiler chickens | |
| Mamabolo et al. | Citric acid in the diet of male Venda chickens: Effects on carcass characteristics and physico-chemical attributes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171201 |
|
| RJ01 | Rejection of invention patent application after publication |