CN110772566A - Traditional Chinese medicine composition for clearing heat and purging fire and preparation method thereof - Google Patents
Traditional Chinese medicine composition for clearing heat and purging fire and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention discloses a traditional Chinese medicine composition for clearing heat and purging fire and a preparation method thereof, and aims to solve the problem that the traditional heat-clearing and purging fire medicine is poor in effect. The invention comprises the following raw materials in parts by weight: 250-300 parts of rhubarb ointment, 175-200 parts of scutellaria ointment, 82.5-115.2 parts of coptis ointment, 200-255 parts of starch, 20-26 parts of carboxymethyl starch sodium, 5.2-5.9 parts of magnesium stearate and 11-13.4 parts of coating agent. The product has the effects of clearing heat, purging fire, detoxifying, removing blood stasis, cooling blood and stopping bleeding by matching the coptis, the rhubarb and the scutellaria, and is used for treating fever, fantod, conjunctival congestion, aphtha, sore throat, gum swelling and pain, constipation, hematemesis, hemoptysis, epistaxis blood, hemorrhoidal bleeding and other symptoms caused by fire toxin and blood heat; can be used for treating pharyngitis, tonsillitis and gingivitis.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for clearing heat and purging fire.
Background
Traditional Chinese medicine is a magnificent wonderful flower in various gardens of world medicine, and in the long rivers of thousands of years of history, the traditional Chinese medicine once made an outstanding contribution to the health career of our nationality, and nowadays when various diseases are increased day by day, the traditional Chinese medicine is a medicine mainly based on herbaceous plant and human medicine, and has unique effects on disease prevention and health preservation of people.
Clearing heat is a term of traditional Chinese medicine, referring to various therapeutic methods for clearing pathogenic heat or deficiency heat, and the heat syndrome includes the difference of heat in qi system, nutrient system, blood system, deficiency heat, excess heat and so on, so the clearing method can be divided into four kinds of herbs for clearing heat and purging fire, clearing heat and cooling blood, clearing heat and removing toxicity, and clearing heat and drying dampness. Heat clearing and fire purging are needed by many people, but no heat clearing and fire purging medicine with good use effect exists at present, and people also carry out research on relevant aspects.
Disclosure of Invention
The embodiment of the invention aims to provide a traditional Chinese medicine composition for clearing heat and purging fire, which is used for solving the problems in the background technology.
In order to achieve the above purpose, the embodiments of the present invention provide the following technical solutions:
a traditional Chinese medicine composition for clearing heat and purging fire comprises the following raw materials in parts by weight: 250-300 parts of rhubarb ointment, 175-200 parts of scutellaria ointment, 82.5-115.2 parts of coptis ointment, 200-255 parts of starch, 20-26 parts of carboxymethyl starch sodium, 5.2-5.9 parts of magnesium stearate and 11-13.4 parts of coating agent.
As a further scheme of the embodiment of the invention: the preparation methods of the rhubarb ointment, the scutellaria ointment and the coptis ointment are as follows: decocting the raw materials with water twice, adding water 10 times of the weight of the raw materials for the first time, decocting for 1-2 hours, adding water 8 times of the weight of the raw materials for the second time, decocting for 0.8-1.4 hours, filtering, combining the decoction, and concentrating the decoction under reduced pressure to obtain thick paste with the relative density of 1.25 at 70 ℃.
As a further scheme of the embodiment of the invention: the starch is corn starch, and the filling and bonding effects are good.
As a further scheme of the embodiment of the invention: the raw materials are carefully selected, cleaned and soaked before being decocted with water, so that the purity of the thick paste is ensured.
As a further scheme of the embodiment of the invention: the temperature of the reduced pressure concentration is 70-80 ℃, the vacuum degree is-0.05-0.08 MPa, and the steam pressure is 0.05-0.2 MPa.
A preparation method of a traditional Chinese medicine composition for clearing heat and purging fire comprises the following specific steps:
step one, weighing raw materials according to a formula for later use;
step two, mixing starch and part of carboxymethyl starch sodium to obtain a first mixture, adding rheum officinale paste, scutellaria baicalensis paste and coptis chinensis paste into the first mixture, and uniformly mixing to obtain a second mixture;
step three, mixing the second mixture, magnesium stearate and the residual carboxymethyl starch sodium to obtain a third mixture;
and step four, tabletting the third mixture, matching a coating agent and a proper amount of water into a coating solution, adding the coating solution into the tabletted third product, cooling, and then inspecting and packaging to obtain a finished product.
As a further scheme of the embodiment of the invention: the magnesium stearate is sieved by a sieve of 80 meshes before use, and the starch and the sodium carboxymethyl starch are sieved by a sieve of 100 meshes before use, so that the uniformity of all raw materials in a finished product is ensured.
As a further scheme of the embodiment of the invention: the weight ratio of the coating agent to the water is 6: 36.5-39.2.
Compared with the prior art, the embodiment of the invention has the beneficial effects that:
the product has the effects of clearing heat, purging fire, detoxifying, removing blood stasis, cooling blood and stopping bleeding by matching the coptis, the rhubarb and the scutellaria, and is used for treating fever, fantod, conjunctival congestion, aphtha, sore throat, gum swelling and pain, constipation, hematemesis, hemoptysis, epistaxis blood, hemorrhoidal bleeding and other symptoms caused by fire toxin and blood heat; can be used for treating pharyngitis, tonsillitis and gingivitis.
Detailed Description
The technical solution of the present patent will be described in further detail with reference to the following embodiments.
Example 1
A traditional Chinese medicine composition for clearing heat and purging fire comprises the following raw materials: 250 kg of rhubarb ointment, 175 kg of scutellaria ointment, 82.5 kg of coptis ointment, 200 kg of starch, 20 kg of carboxymethyl starch sodium, 5.2 kg of magnesium stearate and 11 kg of coating agent. The preparation methods of the rhubarb ointment, the scutellaria ointment and the coptis ointment are as follows: decocting the raw materials with water twice, adding water 10 times the weight of the raw materials for the first time and decocting for 1.3 hr, adding water 8 times the weight of the raw materials for the second time and decocting for 1 hr, filtering and mixing decoctions, and concentrating the decoction under reduced pressure to obtain soft extract with relative density of 1.25 at 70 deg.C.
A preparation method of a traditional Chinese medicine composition for clearing heat and purging fire comprises the following specific steps:
step one, weighing raw materials according to a formula for later use;
step two, mixing starch and part of carboxymethyl starch sodium to obtain a first mixture, adding rheum officinale paste, scutellaria baicalensis paste and coptis chinensis paste into the first mixture, and uniformly mixing to obtain a second mixture;
step three, mixing the second mixture, magnesium stearate and the residual carboxymethyl starch sodium to obtain a third mixture;
and step four, tabletting the third mixture, matching a coating agent and water into a coating solution, wherein the weight ratio of the coating agent to the water is 6:37.3, adding the coating solution into the tabletted third product, cooling, inspecting and packaging to obtain a finished product.
Example 2
A traditional Chinese medicine composition for clearing heat and purging fire comprises the following raw materials: 258.6 kg of rhubarb ointment, 179 kg of scutellaria ointment, 88.4 kg of coptis ointment, 209.5 kg of corn starch, 20.7 kg of carboxymethyl starch sodium, 5.4 kg of magnesium stearate and 11.8 kg of coating agent.
A preparation method of a traditional Chinese medicine composition for clearing heat and purging fire comprises the following specific steps:
weighing raw materials according to a formula, sieving magnesium stearate with a 80-mesh sieve, and sieving corn starch and sodium carboxymethyl starch with a 100-mesh sieve for later use;
step two, mixing corn starch and part of carboxymethyl starch sodium to obtain a first mixture, adding rheum officinale paste, scutellaria baicalensis paste and coptis chinensis paste into the first mixture, and uniformly mixing to obtain a second mixture;
step three, mixing the second mixture, magnesium stearate and the residual carboxymethyl starch sodium to obtain a third mixture;
and step four, tabletting the third mixture, matching a coating agent and a proper amount of water into a coating solution, adding the coating solution into the tabletted third product, cooling, and then inspecting and packaging to obtain a finished product.
Example 3
A traditional Chinese medicine composition for clearing heat and purging fire comprises the following raw materials: 277.3 kg of rhubarb ointment, 184.2 kg of scutellaria ointment, 96.7 kg of coptis ointment, 225 kg of corn starch, 22.5 kg of carboxymethyl starch sodium, 5.5 kg of magnesium stearate and 12 kg of coating agent. The preparation methods of the rhubarb ointment, the scutellaria ointment and the coptis ointment are as follows: selecting, cleaning and soaking the raw materials, adding water, decocting twice, adding 10 times of water by weight of the raw materials for the first time, decocting for 1.5 hours, adding 8 times of water by weight of the raw materials for the second time, decocting for 1 hour, filtering, combining the decoction, and concentrating the decoction under reduced pressure to obtain a thick paste with a relative density of 1.25 at 70 ℃, wherein the temperature of the concentration under reduced pressure is 74 ℃, the vacuum degree is-0.07 MPa, and the steam pressure is 0.12 MPa.
A preparation method of a traditional Chinese medicine composition for clearing heat and purging fire comprises the following specific steps:
weighing raw materials according to a formula, sieving magnesium stearate with a 80-mesh sieve, and sieving corn starch and sodium carboxymethyl starch with a 100-mesh sieve for later use;
step two, mixing starch and part of carboxymethyl starch sodium to obtain a first mixture, adding rheum officinale paste, scutellaria baicalensis paste and coptis chinensis paste into the first mixture, and uniformly mixing to obtain a second mixture;
step three, mixing the second mixture, magnesium stearate and the residual carboxymethyl starch sodium to obtain a third mixture;
and step four, tabletting the third mixture, mixing a coating agent and a proper amount of water into a coating solution, wherein the weight ratio of the coating agent to the water is 6:39.1, adding the coating solution into the tabletted third product, cooling, inspecting and packaging to obtain the finished product.
Example 4
A traditional Chinese medicine composition for clearing heat and purging fire comprises the following raw materials: 291 kg of rhubarb paste, 193.4 kg of scutellaria paste, 106.7 kg of coptis paste, 245.9 kg of starch, 24.8 kg of carboxymethyl starch sodium, 5.7 kg of magnesium stearate and 12.8 kg of coating agent.
A preparation method of a traditional Chinese medicine composition for clearing heat and purging fire comprises the following specific steps:
step one, weighing raw materials according to a formula for later use;
step two, mixing starch and part of carboxymethyl starch sodium to obtain a first mixture, adding rheum officinale paste, scutellaria baicalensis paste and coptis chinensis paste into the first mixture, and uniformly mixing to obtain a second mixture;
step three, mixing the second mixture, magnesium stearate and the residual carboxymethyl starch sodium to obtain a third mixture;
and step four, tabletting the third mixture, matching a coating agent and a proper amount of water into a coating solution, adding the coating solution into the tabletted third product, cooling, and then inspecting and packaging to obtain a finished product.
Example 5
A traditional Chinese medicine composition for clearing heat and purging fire comprises the following raw materials: 300 kg of rhubarb ointment, 200 kg of scutellaria ointment, 115.2 kg of coptis ointment, 255 kg of starch, 26 kg of carboxymethyl starch sodium, 5.9 kg of magnesium stearate and 13.4 kg of coating agent. The preparation methods of the rhubarb ointment, the scutellaria ointment and the coptis ointment are as follows: decocting the raw materials with water twice, adding water 10 times the weight of the raw materials for the first time and decocting for 1.8 hours, adding water 8 times the weight of the raw materials for the second time and decocting for 1.2 hours, filtering and combining the decoction, and concentrating the decoction under reduced pressure to obtain a thick paste with a relative density of 1.25 at 70 ℃, wherein the temperature of the concentration under reduced pressure is 77 ℃, the vacuum degree is-0.05 MPa, and the steam pressure is 0.16 MPa.
A preparation method of a traditional Chinese medicine composition for clearing heat and purging fire comprises the following specific steps:
step one, weighing raw materials according to a formula for later use;
step two, mixing starch and part of carboxymethyl starch sodium to obtain a first mixture, adding rheum officinale paste, scutellaria baicalensis paste and coptis chinensis paste into the first mixture, and uniformly mixing to obtain a second mixture;
step three, mixing the second mixture, magnesium stearate and the residual carboxymethyl starch sodium to obtain a third mixture;
and step four, tabletting the third mixture, matching a coating agent and a proper amount of water into a coating solution, adding the coating solution into the tabletted third product, cooling, and then inspecting and packaging to obtain a finished product.
Experiment 1
400 patients with upper respiratory tract infection, acute pharyngitis with fever, pharyngalgia and cough, laryngitis and tonsillitis are selected, and are randomly and averagely divided into 2 groups, wherein 1 group is treated by the product of the embodiment 1 and the penicillin in a combined way, 2 groups of golden prize is treated by the penicillin, 2 times a day, and the treatment standard is as follows: the effect is shown: the symptoms almost disappeared, were effective: the symptoms were significantly reduced for one week and the treatment data are shown in table 1.
TABLE 1
| Number of effective people | Number of effective persons | Display efficiency | High efficiency | |
| Group 1 | 159A person | 200 persons | 79.5% | 100% |
| 2 groups of | 138 people | 196 people | 69% | 98% |
As can be seen from Table 1, the significant efficiency and the effective rate of the group 1 are higher than those of the group 2, which shows that the product has good effect on treating upper respiratory tract infection, acute pharyngitis with fever, pharyngalgia and cough, laryngitis and tonsillitis.
Experiment 2
The product of example 3 and antihistamine were selected to treat allergic rhinitis, 300 patients were selected and randomized to average 2 groups for 7 days, showing efficacy; the disease is cured and no relapse occurs within half a year, and the treatment effect is recorded and shown in table 2.
TABLE 2
| Number of effective people | Display efficiency | |
| Group 1 | 90 persons | 60% |
| 2 groups of | 48 persons | 32% |
As can be seen from Table 2, the product of example 3 is far superior to antihistamines in treating allergic rhinitis, and the product may be used for treating allergic rhinitis by phagocytosis and elimination of local inflammation, or by exciting reticuloendothelial system, increasing the transformation rate of mother lymphocytes of human lymphatic system, cutting off the transfer of allergen phagocytized by macrophages to B lymphocytes with immune activity, transforming into plasma cells, and failing to generate IgE molecules.
The product can reduce the net absorption of the intestinal membrane to moisture and electrolyte, promote the cracking of fibrinogen, increase the osmotic pressure in the intestinal cavity, prevent the reabsorption of moisture to accelerate the peristalsis of the intestine and promote the peristalsis of intestinal contents, play a role in accelerating defecation, and can clear heat, purge fire, relax bowels and treat constipation.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (7)
1. The traditional Chinese medicine composition for clearing heat and purging fire is characterized by comprising the following raw materials in parts by weight: 250-300 parts of rhubarb ointment, 175-200 parts of scutellaria ointment, 82.5-115.2 parts of coptis ointment, 200-255 parts of starch, 20-26 parts of carboxymethyl starch sodium, 5.2-5.9 parts of magnesium stearate and 11-13.4 parts of coating agent.
2. The heat-clearing fire-purging traditional Chinese medicine composition according to claim 1, wherein the preparation methods of the rhubarb ointment, the scutellaria ointment and the coptis ointment are as follows: decocting the raw materials with water twice, adding water 10 times of the weight of the raw materials for the first time, decocting for 1-2 hours, adding water 8 times of the weight of the raw materials for the second time, decocting for 0.8-1.4 hours, filtering, combining the decoction, and concentrating the decoction under reduced pressure to obtain thick paste with the relative density of 1.25 at 70 ℃.
3. The heat-clearing fire-purging traditional Chinese medicine composition according to claim 1, wherein the starch is corn starch.
4. The heat-clearing fire-purging traditional Chinese medicine composition according to claim 2, characterized in that the raw materials are selected, cleaned and soaked before being decocted with water.
5. The heat-clearing and fire-purging traditional Chinese medicine composition according to claim 2 or 4, wherein the temperature of the reduced pressure concentration is 70-80 ℃, the vacuum degree is-0.05-0.08 MPa, and the steam pressure is 0.05-0.2 MPa.
6. A preparation method of the traditional Chinese medicine composition for clearing heat and purging fire according to any one of claims 1 to 5 is characterized by comprising the following specific steps:
step one, weighing raw materials according to a formula for later use;
step two, mixing starch and part of carboxymethyl starch sodium to obtain a first mixture, adding rheum officinale paste, scutellaria baicalensis paste and coptis chinensis paste into the first mixture, and uniformly mixing to obtain a second mixture;
step three, mixing the second mixture, magnesium stearate and the residual carboxymethyl starch sodium to obtain a third mixture;
and step four, tabletting the third mixture, matching a coating agent and a proper amount of water into a coating solution, adding the coating solution into the tabletted third product, cooling, and then inspecting and packaging to obtain a finished product.
7. The preparation method of the traditional Chinese medicine composition for clearing heat and purging fire according to claim 6, wherein the weight ratio of the coating agent to water is 6: 36.5-39.2.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698757A (en) * | 2005-05-09 | 2005-11-23 | 贵阳云岩西创药物科技开发有限公司 | Pharmaceutical preparation for treating upper respiratory tract infection and its preparation process and quality control method |
| CN1876039A (en) * | 2005-05-09 | 2006-12-13 | 贵阳云岩西创药物科技开发有限公司 | Pharmaceutical composition for treating upper respiratory tract infection, its preparation process and quality control method |
| CN101890087A (en) * | 2010-07-27 | 2010-11-24 | 李钢 | Composition containing coptis root, rhubarb and baikal skullcap root |
| CN102178753A (en) * | 2011-04-11 | 2011-09-14 | 四川省中医药科学院 | Medicinal preparation with effects of clearing heat, purging intense heat, detonicating, eliminating blood stasis, cooling blood and stopping bleeding |
| CN105267327A (en) * | 2015-11-30 | 2016-01-27 | 陕西东泰制药有限公司 | Traditional Chinese medicine composition for clearing heat, removing toxicity, removing blood stasis and cooling blood and preparation method thereof |
-
2019
- 2019-11-07 CN CN201911081519.6A patent/CN110772566A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698757A (en) * | 2005-05-09 | 2005-11-23 | 贵阳云岩西创药物科技开发有限公司 | Pharmaceutical preparation for treating upper respiratory tract infection and its preparation process and quality control method |
| CN1876039A (en) * | 2005-05-09 | 2006-12-13 | 贵阳云岩西创药物科技开发有限公司 | Pharmaceutical composition for treating upper respiratory tract infection, its preparation process and quality control method |
| CN101890087A (en) * | 2010-07-27 | 2010-11-24 | 李钢 | Composition containing coptis root, rhubarb and baikal skullcap root |
| CN102178753A (en) * | 2011-04-11 | 2011-09-14 | 四川省中医药科学院 | Medicinal preparation with effects of clearing heat, purging intense heat, detonicating, eliminating blood stasis, cooling blood and stopping bleeding |
| CN105267327A (en) * | 2015-11-30 | 2016-01-27 | 陕西东泰制药有限公司 | Traditional Chinese medicine composition for clearing heat, removing toxicity, removing blood stasis and cooling blood and preparation method thereof |
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Application publication date: 20200211 |
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