CN110753688A - 用于治疗呼吸系统疾病的化合物 - Google Patents

用于治疗呼吸系统疾病的化合物 Download PDF

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Publication number
CN110753688A
CN110753688A CN201880039084.6A CN201880039084A CN110753688A CN 110753688 A CN110753688 A CN 110753688A CN 201880039084 A CN201880039084 A CN 201880039084A CN 110753688 A CN110753688 A CN 110753688A
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CN
China
Prior art keywords
compound
alkyl
mmol
group
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880039084.6A
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English (en)
Chinese (zh)
Inventor
S·威廉姆斯
S·沙阿
Z·哈基
A·斯图尔特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tianli Biotechnology Co ltd
Original Assignee
University of Melbourne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2017901611A external-priority patent/AU2017901611A0/en
Application filed by University of Melbourne filed Critical University of Melbourne
Publication of CN110753688A publication Critical patent/CN110753688A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201880039084.6A 2017-05-03 2018-05-03 用于治疗呼吸系统疾病的化合物 Pending CN110753688A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2017901611A AU2017901611A0 (en) 2017-05-03 Compounds for the treatment of respiratory diseases
AU2017901611 2017-05-03
AU2017901647 2017-05-05
AU2017901647A AU2017901647A0 (en) 2017-05-05 Compounds for the treatment of respiratory diseases
PCT/AU2018/050404 WO2018201192A1 (en) 2017-05-03 2018-05-03 Compounds for the treatment of respiratory diseases

Publications (1)

Publication Number Publication Date
CN110753688A true CN110753688A (zh) 2020-02-04

Family

ID=64015663

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880039084.6A Pending CN110753688A (zh) 2017-05-03 2018-05-03 用于治疗呼吸系统疾病的化合物

Country Status (9)

Country Link
US (2) US20200079757A1 (enExample)
EP (1) EP3619204B1 (enExample)
JP (2) JP7788128B2 (enExample)
CN (1) CN110753688A (enExample)
AU (3) AU2018262108A1 (enExample)
ES (1) ES3049333T3 (enExample)
FI (1) FI3619204T3 (enExample)
PT (1) PT3619204T (enExample)
WO (1) WO2018201192A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4591936A3 (en) 2015-03-23 2025-10-15 Tianli Biotech Pty Ltd Treatment of respiratory diseases
CN113260616B (zh) * 2018-11-07 2025-05-02 天莅生物技术有限公司 用于治疗呼吸系统疾病的新型化合物
CN110452880B (zh) * 2019-09-09 2021-09-21 温州医科大学附属第一医院 急性肺损伤细胞模型的制备方法及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021452A1 (en) * 1995-01-09 1996-07-18 Smithkline Beecham Corporation Certain 1,4,5-tri-substituted imidazole compounds useful as cytokine
WO1999032121A1 (en) * 1997-12-19 1999-07-01 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses
CN102686580A (zh) * 2009-10-28 2012-09-19 美国辉瑞有限公司 用作酪蛋白激酶抑制剂的咪唑衍生物
WO2016149756A1 (en) * 2015-03-23 2016-09-29 The University Of Melbourne Treatment of respiratory diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593991A (en) * 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
IL110296A (en) * 1993-07-16 1999-12-31 Smithkline Beecham Corp Imidazole compounds process for their preparation and pharmaceutical compositions containing them
IL118544A (en) * 1995-06-07 2001-08-08 Smithkline Beecham Corp History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
CZ2012538A3 (cs) * 2012-08-08 2014-02-19 Masarykova Univerzita Inhibitory pro léčbu B-buněčné chronické lymfocytární leukémie

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021452A1 (en) * 1995-01-09 1996-07-18 Smithkline Beecham Corporation Certain 1,4,5-tri-substituted imidazole compounds useful as cytokine
CN1177299A (zh) * 1995-01-09 1998-03-25 史密丝克莱恩比彻姆公司 用作细胞因子的某些1,4,5－三取代咪唑化合物
WO1999032121A1 (en) * 1997-12-19 1999-07-01 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses
CN102686580A (zh) * 2009-10-28 2012-09-19 美国辉瑞有限公司 用作酪蛋白激酶抑制剂的咪唑衍生物
WO2016149756A1 (en) * 2015-03-23 2016-09-29 The University Of Melbourne Treatment of respiratory diseases

Also Published As

Publication number Publication date
JP2023134493A (ja) 2023-09-27
AU2022202774A1 (en) 2022-05-19
US20200079757A1 (en) 2020-03-12
PT3619204T (pt) 2025-10-29
EP3619204B1 (en) 2025-10-01
AU2024200521A1 (en) 2024-02-15
US20220380343A1 (en) 2022-12-01
AU2018262108A1 (en) 2019-11-21
JP7788128B2 (ja) 2025-12-18
AU2024200521B2 (en) 2025-10-02
FI3619204T3 (fi) 2025-11-06
ES3049333T3 (en) 2025-12-16
EP3619204A4 (en) 2021-03-24
WO2018201192A1 (en) 2018-11-08
JP2020518621A (ja) 2020-06-25
EP3619204A1 (en) 2020-03-11

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TA01 Transfer of patent application right

Effective date of registration: 20231218

Address after: Vitoria Australia

Applicant after: Tianli Biotechnology Co.,Ltd.

Address before: Vitoria Australia

Applicant before: THE University OF MELBOURNE

TA01 Transfer of patent application right