CN110742837B - Anti-inflammatory mask and preparation method thereof - Google Patents
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- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title abstract description 15
- 229940116257 pepper extract Drugs 0.000 claims abstract description 44
- 230000001815 facial effect Effects 0.000 claims abstract description 36
- 235000002566 Capsicum Nutrition 0.000 claims abstract description 27
- 239000006002 Pepper Substances 0.000 claims abstract description 27
- 241000722363 Piper Species 0.000 claims abstract description 27
- 235000016761 Piper aduncum Nutrition 0.000 claims abstract description 27
- 235000017804 Piper guineense Nutrition 0.000 claims abstract description 27
- 235000008184 Piper nigrum Nutrition 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000004821 distillation Methods 0.000 claims abstract description 20
- 239000000284 extract Substances 0.000 claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 13
- 238000002791 soaking Methods 0.000 claims abstract description 13
- 239000002502 liposome Substances 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 11
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 9
- 238000002137 ultrasound extraction Methods 0.000 claims abstract description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 22
- 239000000243 solution Substances 0.000 claims description 18
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
- 239000000839 emulsion Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 239000011780 sodium chloride Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 5
- 238000001704 evaporation Methods 0.000 claims description 3
- 238000001256 steam distillation Methods 0.000 abstract description 8
- 230000003078 antioxidant effect Effects 0.000 abstract description 5
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 239000003921 oil Substances 0.000 description 15
- 239000000341 volatile oil Substances 0.000 description 13
- 244000089698 Zanthoxylum simulans Species 0.000 description 9
- 229930013930 alkaloid Natural products 0.000 description 8
- 150000003797 alkaloid derivatives Chemical class 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 241000949456 Zanthoxylum Species 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 241001480043 Arthrodermataceae Species 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000037304 dermatophytes Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 235000007650 Aralia spinosa Nutrition 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 241001480037 Microsporum Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000001760 anti-analgesic effect Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 238000002390 rotary evaporation Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 241001480035 Epidermophyton Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 241000235342 Saccharomycetes Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- SZCHXNLVRKQEGO-XKDXWZMYSA-N alkaloid b Chemical compound C([C@@]12C=C([C@H]([C@H]2C2=C3)O)OC)CCN1C[C@H](O)C2=CC1=C3OCO1 SZCHXNLVRKQEGO-XKDXWZMYSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
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- 230000003467 diminishing effect Effects 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention relates to the field of cosmetics and discloses an anti-inflammatory mask which comprises mask paper and mask liquid, wherein the mask liquid comprises a pepper extract, phospholipid and auxiliary materials; the preparation method of the anti-inflammatory mask comprises the steps of performing steam distillation on pepper powder, preparing liposome of an extract, performing ultrasonic extraction on a water layer after distillation, soaking mask paper and the like; the facial mask prepared by the preparation method has better anti-inflammatory and antioxidant effects, and meanwhile, the facial mask does not cake and does not generate floccules.
Description
Technical Field
The invention relates to the field of cosmetics, and particularly relates to an anti-inflammation mask and a preparation method thereof.
Background
The facial mask is gradually becoming an indispensable skin care product in daily beauty and maintenance of women, and has a great number of effects, such as moisturizing, freckle removing and whitening, inflammation diminishing and bacteria resisting and the like. At present, there are two main types of anti-inflammatory masks in the market, one is to add various chemical additives with anti-inflammatory components, and the addition of the chemical components can cause some users to easily have symptoms such as allergy and the like, and aggravate the inflammatory condition. The other is adding a plurality of traditional Chinese medicine extracts with anti-inflammatory effect, however, the addition of the traditional Chinese medicine components can shorten the shelf life of the mask, and the mask is not easy to store and easy to agglomerate.
The pepper, as a rutaceae plant, is often used as a food seasoning, and besides, the pepper also has good antibacterial, antioxidant, anti-inflammatory and analgesic effects, and can be used in the fields of daily chemicals and the like. At present, part of researches on adding pepper extract as a preservative into the facial mask can prolong the shelf life of the facial mask and simultaneously prevent allergic reactions of users. However, the antioxidant component of zanthoxylum is mostly extracted by a solvent extraction method, so that the content of the anti-inflammatory component in zanthoxylum is low, and the anti-inflammatory and analgesic effects cannot be achieved. Therefore, a mask with natural components, better anti-inflammatory and antioxidant effects and no caking is urgently needed to be found.
Disclosure of Invention
Aiming at the problems, the invention aims to provide an anti-inflammatory facial mask which is natural in components, has better anti-inflammatory and antioxidant effects, does not agglomerate and does not generate floccules and a preparation method thereof.
The pepper contains various active substances such as abundant volatile oil, alkaloid, total flavonoids and the like, but the properties of each active ingredient are different, and the content difference of different active ingredients extracted by different methods is large. Therefore, in order to make the anti-inflammatory and antiseptic effects of the facial mask better, the anti-inflammatory and antiseptic components extracted from the pepper with high content and high purity cannot be extracted by using the traditional solvent and supercritical CO2Extraction and the like.
In order to achieve the purpose, the following technical scheme is adopted:
the first scheme is as follows:
an anti-inflammatory facial mask comprises facial mask paper and facial mask liquid, and is characterized in that the facial mask liquid comprises a pepper extract and auxiliary materials.
Further, the pepper extract is a pepper extract A and a pepper extract B.
A preparation method of an anti-inflammatory mask comprises the following steps:
firstly, cleaning and airing the pepper, crushing and sieving by a sieve of 60-80 meshes to obtain pepper powder for later use;
secondly, according to the material-liquid ratio of 1: 10-1: 15 mixing and soaking the pepper powder and water for 4-6h, adding the mixture into a distillation flask for steam distillation, collecting emulsion in the distillation flask, adding a NaCl solution into the emulsion, and separating an oil layer from a water layer to obtain an oil layer for later use;
③ adding anhydrous Na into the oil layer2SO4Filtering to obtain fructus Zanthoxyli extract A;
fourthly, placing the water layer in the second step into an ultrasonic extractor, extracting for 20-40min each time for 2-5 times by ultrasonic, collecting and combining products extracted each time to obtain a pepper extract B;
fifthly, soaking the facial mask paper in a mixed solution of the pepper extract A liposome, the pepper extract B and the auxiliary materials for 10-20h to obtain the anti-inflammatory facial mask.
Furthermore, the temperature of the steam distillation in the step II is 80-110 ℃, and the distillation time is 6-8 h.
Further, the mass concentration of the NaCl solution in the step (II) is 0.3-0.5 g/mL.
Furthermore, the ultrasonic frequency in the fifth step is 110 kHz.
According to the first scheme, the volatile oil of the pepper extract A is extracted by adopting a steam distillation method, the alkaloid of the pepper extract B is obtained by adopting an ultrasonic extraction method, the pepper extract and auxiliary materials are mixed and directly soaked in the facial mask paper to obtain the anti-inflammatory facial mask, floccules easily appear, the use of the facial mask is directly influenced, and in order to solve the problem, the inventor improves the first scheme again, so that the following technical scheme is adopted:
scheme II:
an anti-inflammatory facial mask comprises facial mask paper and facial mask liquid, and is characterized in that the facial mask liquid comprises a pepper extract, phospholipid and auxiliary materials.
Further, the pepper extract is a pepper extract A and a pepper extract B.
A preparation method of an anti-inflammatory mask comprises the following steps:
firstly, cleaning and airing the pepper, crushing and sieving by a sieve of 60-80 meshes to obtain pepper powder for later use;
secondly, according to the material-liquid ratio of 1: 10-1: 15 mixing and soaking the pepper powder and water for 4-6h, adding the mixture into a distillation flask for steam distillation, collecting emulsion in the distillation flask, adding a NaCl solution into the emulsion, and separating an oil layer from a water layer to obtain an oil layer for later use;
③ adding anhydrous Na into the oil layer2SO4Filtering to obtain fructus Zanthoxyli extract A;
fourthly, dissolving phospholipid in chloroform, then carrying out rotary evaporation on the chloroform solution in a flask to form a layer of film on the inner wall of the flask, adding the pepper extract A into the flask and continuously stirring to obtain pepper extract A liposome for later use;
fifthly, putting the water layer in the second step into an ultrasonic extractor, extracting for 20-40min each time for 2-5 times by ultrasonic, collecting and combining the products extracted each time to obtain a pepper extract B;
sixthly, soaking the facial mask paper in the mixed solution of the pepper extract A liposome, the pepper extract B and the auxiliary materials for 10-20h to obtain the anti-inflammatory facial mask.
Furthermore, the temperature of the steam distillation in the step II is 80-110 ℃, and the distillation time is 6-8 h.
Further, the mass concentration of the NaCl solution in the step (II) is 0.3-0.5 g/mL.
Further, the concentration of chloroform in the step (iv) is 1 g/mL.
Furthermore, the ultrasonic frequency in the fifth step is 110 kHz.
It should be noted that the technical effect of the present invention is the result of mutual cooperation and interaction of each process step and parameter, and is not the superposition of simple processes, and the effect produced by the organic combination of each process is far superior to the superposition of each single process function and effect, and has better advancement and practicability.
Compared with the prior art, the invention has the following technical effects:
1. the invention adopts a steam extraction method to extract the volatile oil A of the zanthoxylum bungeanum maxim extract, the purity of the volatile oil A can reach 100 percent, and the volatile oil of the zanthoxylum bungeanum maxim has stronger bacteriostatic action on superficial dermatophytes such as floccus epidermophyton, microsporum lanosum and the like and can be used as a natural anti-inflammatory component.
2. The pepper volatile oil is hydrophobic and unstable, and is easy to agglomerate to generate floccules after being directly added into the mask and placed for a long time.
3. The invention carries out further ultrasonic extraction on the water layer after the water vapor extraction to obtain the alkaloid B of the pepper extract, the alkaloid in the pepper has strong antibacterial activity and has inhibition effect on escherichia coli and bacillus anthracis, thus the pepper extract can be used as a natural preservative. Meanwhile, the zanthoxylum bungeanum alkaloid has certain bacteriostasis and sterilization effects on 11 dermatophytes and 4 deep fungi, and the combined action of the zanthoxylum bungeanum alkaloid and the zanthoxylum bungeanum volatile oil further enhances the anti-inflammation and bacteriostasis performance of the mask.
Detailed Description
For further understanding of the present invention, the method and effects of the present invention will be described in further detail with reference to specific examples. It should be noted that the present embodiment is only for further illustration of the present invention and should not be construed as limiting the scope of the present invention, and that those skilled in the art can make modifications and adjustments in a non-essential way based on the above disclosure.
Example 1
A preparation method of an anti-inflammatory mask comprises the following steps:
firstly, cleaning and airing the pepper, crushing and then sieving by a 60-mesh sieve to obtain pepper powder for later use;
secondly, according to the material-liquid ratio of 1: 10 mixing and soaking the pepper powder and water for 4 hours, adding the mixture into a distillation flask, distilling the mixture by using steam at the distillation temperature of 100 ℃ for 7 hours, collecting emulsion in the distillation flask, adding NaCl solution with the mass concentration of 0.3 g/mL into the emulsion, and separating an oil layer from a water layer to obtain an oil layer for later use;
③ adding anhydrous Na into the oil layer2SO4Filtering to obtain fructus Zanthoxyli extract A;
dissolving phospholipid in chloroform with the concentration of 1g/mL, rotationally evaporating the chloroform solution in a flask to form a layer of film on the inner wall of the flask, adding the pepper extract A into the flask and continuously stirring to obtain pepper extract A liposome for later use;
fifthly, putting the water layer in the second step into an ultrasonic extractor, extracting for 3 times with ultrasonic wave at the ultrasonic frequency of 110kHz for 30min each time, collecting and combining products extracted for 3 times to obtain a pepper extract B;
sixthly, soaking the facial mask paper in the mixed solution of the pepper extract A liposome, the pepper extract B and the auxiliary materials for 20 hours to obtain the anti-inflammatory facial mask.
The mask obtained in this example did not show floc and clumping after a long time of standing.
Example 2
A preparation method of an anti-inflammatory mask comprises the following steps:
firstly, cleaning and airing the pepper, crushing and sieving by a 80-mesh sieve to obtain pepper powder for later use;
secondly, according to the material-liquid ratio of 1: 15 mixing and soaking the pepper powder and water for 5 hours, adding the mixture into a distillation flask, distilling the mixture by using steam at the distillation temperature of 110 ℃ for 6 hours, collecting emulsion in the distillation flask, adding NaCl solution with the mass concentration of 0.5g/mL into the emulsion, and separating an oil layer from a water layer to obtain an oil layer for later use;
③ adding anhydrous Na into the oil layer2SO4Filtering to obtain fructus Zanthoxyli extract A;
dissolving phospholipid in chloroform with the concentration of 1g/mL, rotationally evaporating the chloroform solution in a flask to form a layer of film on the inner wall of the flask, adding the pepper extract A into the flask and continuously stirring to obtain pepper extract A liposome for later use;
fifthly, putting the water layer in the second step into an ultrasonic extractor, extracting for 4 times and 204min each time by ultrasonic with the wave frequency of 110kHz, collecting and combining the products extracted each time to obtain a pepper extract B;
sixthly, soaking the facial mask paper in the mixed solution of the pepper extract A liposome, the pepper extract B and the auxiliary materials for 15 hours to obtain the anti-inflammatory facial mask.
The mask obtained in this example did not show floc and clumping after a long time of standing.
Example 3
A preparation method of an anti-inflammatory mask comprises the following steps:
cleaning and airing the pepper, crushing and sieving by a 70-mesh sieve to obtain pepper powder for later use;
secondly, according to the material-liquid ratio of 1: 12 mixing and soaking the pepper powder and water for 6 hours, adding the mixture into a distillation flask, distilling the mixture by using steam at the distillation temperature of 90 ℃ for 8 hours, collecting emulsion in the distillation flask, adding NaCl solution with the mass concentration of 0.4g/mL into the emulsion, and separating an oil layer from a water layer to obtain an oil layer for later use;
③ adding anhydrous Na into the oil layer2SO4Filtering to obtain fructus Zanthoxyli extract A;
dissolving phospholipid in chloroform with the concentration of 1g/m, performing rotary evaporation on the chloroform solution in a flask to form a layer of film on the inner wall of the flask, adding the pepper extract A into the flask and continuously stirring to obtain pepper extract A liposome for later use;
fifthly, putting the water layer in the second step into an ultrasonic extractor, extracting for 2 times and 30min each time at the frequency of 110kHz, collecting and combining the products extracted each time to obtain a pepper extract B;
sixthly, soaking the facial mask paper in the mixed solution of the pepper extract A liposome, the pepper extract B and the auxiliary materials for 20 hours to obtain the anti-inflammatory facial mask.
The mask obtained in this example did not show floc and clumping after a long time of standing.
Comparative example 1
Compared with example 1, the preparation method of the anti-inflammatory facial mask omits the ultrasonic extraction of the zanthoxylum bungeanum extract B of the water layer, namely the zanthoxylum bungeanum extract A extracted by only adding steam distillation, and the rest operations are the same.
Comparative example 2
Compared with the preparation method of the example 1, the method for preparing the anti-inflammatory facial mask cancels the zanthoxylum bungeanum extract A extracted by steam distillation, namely only adds the zanthoxylum bungeanum extract B extracted by ultrasonic wave, and the rest operations are the same.
Comparative example 3
Compared with the preparation method of the anti-inflammatory mask in the embodiment 1, the step (IV) is omitted, namely the pepper extract A volatile oil is not embedded by phospholipid, and the rest operations are the same.
The mask obtained in this comparative example exhibited the appearance of flocs and lumps after a long-term storage.
And (3) bacteriostatic test:
test strains: staphylococcus aureus, escherichia coli, saccharomycetes and microsporum lanosum.
The test method comprises the following steps: respectively preparing bacterial suspension from the tested strains, and respectively injecting the bacterial suspension into corresponding sterilized liquid culture dishes. The filter paper sheets soaked with the anti-inflammatory mask solutions of examples 1-3 and comparative examples 1-2 were slightly air-dried and placed in culture dishes, 3 sheets of the filter paper sheets were placed in each culture dish, and were completely contacted with the culture medium, and were placed in an incubator for culture, and staphylococcus aureus and escherichia coli were cultured at 37 ℃ for 24 hours, and yeast-like bacteria was cultured at 28 ℃ for 30 hours, and were taken out for observation, and the diameter (mm) of the zone of inhibition was measured with a vernier caliper, and three parallel samples were set for each group, and the results were averaged. The test results are shown in table 1.
TABLE 1
The results in table 1 show that the anti-inflammatory mask disclosed by the embodiment of the invention has a better inhibiting effect on pathogenic bacteria such as escherichia coli and superficial dermatophytes, and the inhibiting effect is obviously weaker than that of the mask prepared by adding the volatile oil and the alkaloid in the embodiment of the invention when only the pricklyash peel volatile oil or the pricklyash peel alkaloid is added.
In conclusion, the anti-inflammatory facial mask is obtained by distilling the pepper by using water vapor to obtain the volatile oil extract, embedding the volatile oil by using phospholipid to improve the solubility and stability of the volatile oil, then performing ultrasonic extraction on the water layer separated by distillation to obtain the alkaloid extract, and finally mixing the extract with auxiliary materials to soak facial mask paper. By adopting the series of preparation methods, the extraction utilization rate of active ingredients in the pepper is improved, the anti-inflammatory property of the facial mask is enhanced, and the finally obtained anti-inflammatory facial mask is not agglomerated and does not generate floccules.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (1)
1. A method for preparing an anti-inflammatory mask, comprising the steps of:
firstly, cleaning and airing the pepper, crushing and sieving by a sieve of 60-80 meshes to obtain pepper powder for later use;
secondly, according to the material-liquid ratio of 1: 10-1: 15 mixing and soaking the pepper powder and water for 4-6h, adding the mixture into a distillation flask, distilling the mixture by using steam at the distillation temperature of 80-110 ℃ for 6-8h, collecting emulsion in the distillation flask, adding NaCl solution with the mass concentration of 0.3-0.5g/mL into the emulsion, and separating an oil layer from a water layer to obtain an oil layer for later use;
③ adding anhydrous Na into the oil layer2SO4Filtering to obtain fructus Zanthoxyli extract A;
fourthly, dissolving phospholipid in chloroform, rotationally evaporating the chloroform solution with the concentration of 1g/mL in a flask to form a layer of film on the inner wall of the flask, adding the pepper extract A into the flask and continuously stirring to obtain pepper extract A liposome for later use;
fifthly, putting the water layer in the second step into an ultrasonic extractor, performing ultrasonic extraction for 2-5 times at the frequency of 110kHz, each time for 20-40min, collecting and combining products extracted each time to obtain a pepper extract B;
sixthly, soaking the facial mask paper in the mixed solution of the pepper extract A liposome, the pepper extract B and the auxiliary materials for 10-20h to obtain the anti-inflammatory facial mask.
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