CN107349124A - A kind of preservative and its application - Google Patents
A kind of preservative and its application Download PDFInfo
- Publication number
- CN107349124A CN107349124A CN201710696213.6A CN201710696213A CN107349124A CN 107349124 A CN107349124 A CN 107349124A CN 201710696213 A CN201710696213 A CN 201710696213A CN 107349124 A CN107349124 A CN 107349124A
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- CN
- China
- Prior art keywords
- preservative
- brazilin
- galangin
- ethanol
- chicory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention discloses a kind of preservative and its application, the preservative is made up of the component of following mass percent:Brazilin 0.2 2.5%, chicory sesquiterpene lactone class compound 0.1 2.0%, Galangin 0.2 2.3%.All raw materials of preservative of the present invention all derive from natural plants, and the multiple efficacies composition being rich in reconciles mutually, Synergistic, product is had significant antiseptic effect.Preservative of the present invention can be applied to eye mask as cosmetics preservative, substitute the use of chemical synthesis preservative completely, improve Product Safety, it is non-stimulated, without allergy, have no toxic side effect, while do not interfere with the stability of cosmetics.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of preservative and its application.
Background technology
Preservative just refers to the material that microorganism can be prevented to grow.In cosmetics, the effect of preservative is protection production
Product, it is allowed to from microorganism pollution.Cosmetics are easily caused rotten by microorganism pollution, generally, just can in outward appearance
Reflect.Such as often there is mildew in the packaging edge place of product in yeast and mold;By the product of microorganism pollution
Become turbid, precipitate, color change, pH value change, foaming, spoiled, blocking etc. if emulsified body is then likely to occur demulsification.
If the amount of preservative addition is inadequate, the growing environment that microorganism adapts to surrounding is likely to occur, is developed immunity to drugs, so as to cause
Anti-corrosion fails.All it is chemical synthesis preservative used in current most of cosmetics companies, and chemical synthesis preservative is deposited
It is not fine in terms of security excitant is big, toxicity is big the defects of.Present consumer pays special attention to consumer safety,
Tend to using it is natural, non-stimulated, without it is allergic the problems such as product.Therefore, exploitation it is a kind of safe and reliable, efficiently, without dirt
The preservative of dye into there is an urgent need to.
The content of the invention
In view of the shortcomings of the prior art, it is an object of the invention to provide a kind of preservative, its by several natural plants into
Be grouped into, can suppress growth of microorganism, and have the advantages that it is nontoxic, non-stimulated, without allergic.
To achieve the above object, the present invention provides following technical scheme:
A kind of preservative includes the component of following mass percent:Brazilin 0.2-2.5%, chicory sesquiterpene lactone
Class compound 0.1-2.0%, Galangin 0.2-2.3%.
Further, described preservative includes the component of following mass percent:Brazilin 0.4-2.0%, chrysanthemum
Lettuce Sesquiterpene lactones compound 0.3-1.8%, Galangin 0.5-2.0%.
Preferably, described preservative includes the component of following mass percent:Brazilin 0.6-1.5%, witloof
Sesquiterpene lactones compound 0.5-1.0%, Galangin 0.7-1.2%.
Further, the preparation method of described brazilin is as follows:Weigh Brazil wood medicinal material, cleaning, drying, powder
It is broken, obtain Brazil wood medicinal powder;According to feed liquid 1:15 add the ethanol that volume fraction is 95%, heating and refluxing extraction, recovery
Solvent obtains Brazil wood crude extract, filtering, and filter residue is repeated into extraction 2 times;Then add ethyl acetate to be extracted, tie again
After crystalline substance, brazilin is obtained.
Further, the preparation method of described chicory sesquiterpene lactone class compound is as follows:Witloof is weighed, after drying,
According to solid-liquid ratio 1:15 add the ethanol that volume fraction is 85%, repeat extraction three times, merging filtrate, are concentrated under reduced pressure, add 2 times
The water of amount is suspended;Then extracted with ethyl acetate, be concentrated under reduced pressure each extract;Through silica gel column chromatography, witloof is obtained after elution
Sesquiterpene lactones compound.
Further, the preparation method of described Galangin is:Galangal is weighed, 80 mesh are dry, pulverize into, according to material
Liquor ratio 1:10 add 95% alcohol reflux 2 times, each 1.5h, merge 2 filtrates;Rotary Evaporators concentration is placed in, is measured with 2 times
Petroleum ether carries out degreasing, is extracted 2 times in the chloroform for adding 2 times of amounts, merges 2 chloroform extracts;Chloroform solution, which is concentrated under reduced pressure, puts leaching
Cream, upper treated polyamide column, post is rushed with water, 20% ethanol, 40% ethanol successively, then with 50% ethanol, 60% ethanol
Post is rushed, collects 50% cut;50% cut is concentrated under reduced pressure, cool overnight, separates out precipitation, is filtered, recrystallization, obtains galangal
Element.
The present invention also provides a kind of application of preservative in cosmetics are prepared, and described cosmetics are eye mask.
Further, described eye mask includes the component of following mass percent:A kind of above-mentioned preservative 1.8-
3.7%th, butanediol 2.5-3.6%, glycerine 3.2-4.5%, propane diols 1.5-4.7%, Natrulon H-10 1.2-3.4%, trehalose
0.6-1.2%, Hydrolyzed Collagen 0.4-1.0%, Gotu Kola P.E 0.04-0.08%, Baical Skullcap root P.E 0.01-
0.05%th, Margarita extract 0.01-0.05%, Sodium Hyaluronate 0.1-0.6%, glyceryl acrylate/acrylic copolymer
0.2-0.7%, carbomer 0.1-0.25%, deionized water surplus.
Several components in preservative of the present invention are introduced below:
Brazilin, also known as brasilin, brazilin, brasilin, be bush main active, together
A kind of natural pigments of Shi Zuowei are usually used in pathological tissue dyeing.Brazilin belongs to the derivative of homoisoflavone class compound,
With a variety of pharmacological activity such as antibacterial, anti-inflammatory, hypoglycemic, immunological regulation.As the active ingredient of antibacterial, brazilin is to one
The bacterium of a little antibiotic-resistants, the enterococcus of staphylococcus aureus, vancomycin resistance such as methicillin-resistant and multi-drug resistant
Burkholderia cepacia and other bacteriums have significant inhibitory action, and its minimal inhibitory concentration is 4~32 μ g/mL.Research
Show, the growth of bush methanolic extract and 50% ethanol extract to propionibacterium acnes has obvious inhibitory action, enters
One step separates to methanolic extract, obtains brazilin, and protosappanin A and hematoxylone B, active ingredients result show,
Brazilin has stronger antibacterial activity, MIC 0.5mg/mL compared with protosappanin A and hematoxylone B.
Witloof is the dry aerial parts or root of feverfew witloof and saussurea intybus, also known as blue chrysanthemum.Mainly contained in witloof
The chemical compositions such as polysaccharide, terpene (especially sesquiterpenoids), flavonoids and phenolic acid class.Witloof aerial part and root extract tool
There is significant antibacterial activity.Research shows that cichory root ethyl acetate extract shows stronger suppression than other solvent extractable matters
Bacterium activity, to be better than gamboge micro- for inhibitory action of the extract to bacillus subtilis, staphylococcus aureus, salmonella typhi
Coccus and Escherichia coli.Chicory root extract also has very strong antifungal activity.
Alpinia system zingiberaceous plant, about 250 kinds of the whole world, Tropical Asian area is distributed in, China there are 46 kinds, produces the west and south
To Taiwan, the platymiscium has important medical value, has anti-inflammation, the analgesia that helps digestion, warm stomach preventing or arresting vomiting and other effects.Study table
Bright, the D in the ethanol extract of Alpinia galanga, L-1 '-acetoxy-chavicol-acetate have stronger to staphylococcus aureus
Bacteriostatic activity, and gram-positive bacteria and saccharomycete are also more sensitive to it, particularly staphylococcus.40% ethanol extracts
Thing can suppress staphylococcus aureus, α-hemolytic streptococcus, beta hemolytic streptococcus and streptococcus pneumonia.These activity
It is relevant to the inhibitory action of β -one acyl-ACP reductases with it.
Compared with prior art, it is the device have the advantages that as follows:Preservative of the present invention is by brazilin, witloof
Sesquiterpene lactones compound, Galangin form in specific proportions, by suppressing β -one acyl-ACP reductases, suppress thin
Bacterium, the growth of fungi, 3 kinds of composition cooperative effects, to play more effective antisepsis.Wherein, brazilin is resistance to some
The bacterium of antibiotic, the enterococcus and multi-drug resistant onion of staphylococcus aureus, vancomycin resistance such as methicillin-resistant
Burkholderia and other bacteriums have significant inhibitory action;Chicory sesquiterpene lactone class compound, Galangin are all right
The fungies such as staphylococcus aureus play antibacterial action, three's synergy, effectively play antimicrobial preservative efficacy.Preservative of the present invention
Eye mask can be applied to as cosmetics preservative, substitute the use of chemical synthesis preservative completely, improve Product Safety, it is right
Eye skin is non-stimulated, without allergy, have no toxic side effect, while do not interfere with the stability of cosmetics.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated:
All the components appeared in text are INCI (International Nomenclature Cosmetic
Ingredient), i.e., international cosmetic raw material is obviously said to its defined title.
The eye mask embodiment 1~5 of the present invention is formulated, and is shown in Table 1.
Table 1
1. the preparation method of brazilin is as follows:
Brazil wood medicinal material is weighed, cleaning, drying, crushes, obtains Brazil wood medicinal powder;According to feed liquid 1:15 add body
Fraction is 95% ethanol, and heating and refluxing extraction, recycling design obtains Brazil wood crude extract, filters, filter residue is repeated
Extraction 2 times;Then add ethyl acetate to be extracted, after recrystallization, obtain brazilin.
2. the preparation method of chicory sesquiterpene lactone class compound is as follows:
Witloof is weighed, after drying, according to solid-liquid ratio 1:15 add the ethanol that volume fraction is 85%, repeat extraction three times,
Merging filtrate, it is concentrated under reduced pressure, the water for adding 2 times of amounts is suspended;Then extracted with ethyl acetate, be concentrated under reduced pressure each extract;
Through silica gel column chromatography, chicory sesquiterpene lactone class compound is obtained after elution.
3. the preparation method of Galangin is:
Galangal is weighed, dry, pulverize into 80 mesh, according to solid-liquid ratio 1:10 add 95% alcohol reflux 2 times, every time
1.5h, merge 2 filtrates;Rotary Evaporators concentration is placed in, degreasing is carried out with the petroleum ether of 2 times of amounts, is adding the chloroform of 2 times of amounts
Extraction 2 times, merge 2 chloroform extracts;Chloroform solution, which is concentrated under reduced pressure, puts medicinal extract, upper treated polyamide column, successively with water,
20% ethanol, 40% ethanol rush post, then rush post with 50% ethanol, 60% ethanol, collect 50% cut;50% cut is depressurized
Concentration, cool overnight, precipitation is separated out, filtered, recrystallization, obtain Galangin.
Comparative example 1:
Brazilin is not added in difference with embodiment 3 only, and remaining each material addition, conditions and technology of preparation is not
Change.
Comparative example 2:
Chicory sesquiterpene lactone class compound is not added in difference with embodiment 3 only, remaining each material addition, prepares bar
Part does not change with technique.
Comparative example 3:
Galangin is not added in difference with embodiment 3 only, and remaining each material addition, conditions and technology of preparation is not sent out
It is raw to change.
Comparative example 4:
Compared with Example 3, brazilin, chicory sesquiterpene lactone class compound, Galangin do not add, remaining
Each material addition, conditions and technology of preparation do not change still.
Bacteriostasis efficacy is verified:
This experiment is made to represent using staphylococcus aureus, Escherichia coli and propionibacterium acne, and it is anti-to participate in the present invention
The bacteriostasis test of rotten agent.Filter paper is cut into the φ 5mm scraps of paper using card punch, by standby after high-temperature sterilization, then used
Sterilizing filter paper piece is respectively placed in the counter sample liquid that each example or sterilized water configuration forms by clean tweezers, is dried in the air after soaking half an hour
It is dry, it is standby after mark.
Fixed with pipette and draw 0.1mL bacteria suspensions in sterile petri dish, pour into the sterilising medium of 15mL coolings,
, will be each after natural condensation and type of culture medium changes, the horizontal rest after culture medium fully mixes because corresponding strain is different
The individual scraps of paper are smooth in culture dish, are placed in very steady 37 DEG C of incubator and cultivate 1~2 day.Culture is unified after terminating to take out sample, and makes
Antibacterial circle diameter is determined with the survey tool of unified standard, collects rear list, such as table 2.
Table 2
From general knowledge, sterilized water does not have an antibacterial ability substantially, and the basic eye that this experiment uses as can be found from Table 2
Film formulation sample, the i.e. antibacterial ability of comparative example 4 can also be ignored.
After preservative fractions of the present invention are added into basic components, antibacterial ability is improved, but actually anti-
Bacterium ability is still not enough to reach demand.
Finally by embodiment data it can be found that after adding preservative whole composition of the present invention in proportion, antibacterial ability obtains
To being substantially improved, the reason for this is that each composition has certain antibacterial ability in itself in composition, its antibacterial mechanisms is variant,
Its antibacterial effect, and then required antibacterial purpose can be further enhanced by the principle with difference but complementation after combination.
Above example is merely to illustrate embodiment of the present invention, does not have any formal limit to the present invention
System;It is any to be engaged in professional and technical personnel, all have the ability using the technology contents having revealed that, some are made to it and changes or repaiies
Decorations, turn into the equivalent embodiment of equivalent variations.According to the technology of the present invention essence, simply modification, equivalent variations are carried out to the present invention
With modification, belong in the range of technical solution of the present invention.
Claims (9)
1. a kind of preservative, it is characterised in that described preservative includes the component of following mass percent:Brazilin
0.2-2.5%, chicory sesquiterpene lactone class compound 0.1-2.0%, Galangin 0.2-2.3%.
2. where basis requires a kind of preservative described in 1, it is characterised in that described preservative includes following quality percentage
The component of ratio:Brazilin 0.4-2.0%, chicory sesquiterpene lactone class compound 0.3-1.8%, Galangin 0.5-
2.0%.
3. a kind of preservative according to claim 2, it is characterised in that described preservative includes following mass percent
Component:Brazilin 0.6-1.5%, chicory sesquiterpene lactone class compound 0.5-1.0%, Galangin 0.7-1.2%.
4. according to a kind of preservative described in claim any one of 1-3, it is characterised in that the preparation of described brazilin
Method is as follows:Brazil wood medicinal material is weighed, cleaning, drying, crushes, obtains Brazil wood medicinal powder;According to feed liquid 1:15 add
Volume fraction is 95% ethanol, and heating and refluxing extraction, recycling design obtains Brazil wood crude extract, is filtered, by filter residue weight
Extract 2 times again;Then add ethyl acetate to be extracted, after recrystallization, obtain brazilin.
5. according to a kind of preservative described in claim any one of 1-3, it is characterised in that described chicory sesquiterpene lactone class
The preparation method of compound is as follows:Witloof is weighed, after drying, according to solid-liquid ratio 1:15 add the ethanol that volume fraction is 85%,
Repeat extraction three times, merging filtrate, be concentrated under reduced pressure, the water for adding 2 times of amounts is suspended;Then extracted, depressurized with ethyl acetate
Concentrate each extract;Through silica gel column chromatography, chicory sesquiterpene lactone class compound is obtained after elution.
6. according to a kind of preservative described in claim any one of 1-3, it is characterised in that the preparation side of described Galangin
Method is:Galangal is weighed, dry, pulverize into 80 mesh, according to solid-liquid ratio 1:10 add 95% alcohol reflux 2 times, each 1.5h, close
And 2 filtrates;Rotary Evaporators concentration is placed in, degreasing is carried out with the petroleum ether of 2 times of amounts, is adding the chloroform extraction 2 of 2 times of amounts
It is secondary, merge 2 chloroform extracts;Chloroform solution, which is concentrated under reduced pressure, puts medicinal extract, upper treated polyamide column, successively with water, 20% second
Alcohol, 40% ethanol rush post, then rush post with 50% ethanol, 60% ethanol, collect 50% cut;50% cut is concentrated under reduced pressure,
Cool overnight, precipitation is separated out, filtered, recrystallization, obtain Galangin.
A kind of 7. application of the preservative according to claim any one of 1-6 in cosmetics are prepared.
8. application according to claim 7, it is characterised in that described cosmetics are eye mask.
9. a kind of eye mask containing natural antiseptic agent, it is characterised in that described eye mask includes the component of following mass percent:Such as
A kind of preservative 1.8-3.7%, butanediol 2.5-3.6%, glycerine 3.2-4.5%, propane diols 1.5- described in claim 1
4.7%th, Natrulon H-10 1.2-3.4%, trehalose 0.6-1.2%, Hydrolyzed Collagen 0.4-1.0%, Gotu Kola P.E
0.04-0.08%, Baical Skullcap root P.E 0.01-0.05%, Margarita extract 0.01-0.05%, Sodium Hyaluronate 0.1-0.6%,
Glyceryl acrylate/acrylic copolymer 0.2-0.7%, carbomer 0.1-0.25%, deionized water surplus.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112545979A (en) * | 2021-01-12 | 2021-03-26 | 山西省肿瘤研究所 | Perfusion gel for preventing postoperative recurrence of bladder cancer and preparation method and application thereof |
CN112891299A (en) * | 2021-02-01 | 2021-06-04 | 遵义医科大学附属医院 | Brazilian hematoxylin emulsifiable paste and preparation method thereof |
WO2023170340A1 (en) | 2022-03-10 | 2023-09-14 | Teknologian Tutkimuskeskus Vtt Oy | Method of producing antimicrobial extract from chicory |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107374997A (en) * | 2017-06-21 | 2017-11-24 | 佛山实瑞先导材料研究院(普通合伙) | A kind of preservative and its application |
-
2017
- 2017-08-14 CN CN201710696213.6A patent/CN107349124A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107374997A (en) * | 2017-06-21 | 2017-11-24 | 佛山实瑞先导材料研究院(普通合伙) | A kind of preservative and its application |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112545979A (en) * | 2021-01-12 | 2021-03-26 | 山西省肿瘤研究所 | Perfusion gel for preventing postoperative recurrence of bladder cancer and preparation method and application thereof |
CN112891299A (en) * | 2021-02-01 | 2021-06-04 | 遵义医科大学附属医院 | Brazilian hematoxylin emulsifiable paste and preparation method thereof |
WO2023170340A1 (en) | 2022-03-10 | 2023-09-14 | Teknologian Tutkimuskeskus Vtt Oy | Method of producing antimicrobial extract from chicory |
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