CN110740753A - 一种抗体药物偶联物中间体的制备工艺 - Google Patents

一种抗体药物偶联物中间体的制备工艺 Download PDF

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CN110740753A
CN110740753A CN201980002405.XA CN201980002405A CN110740753A CN 110740753 A CN110740753 A CN 110740753A CN 201980002405 A CN201980002405 A CN 201980002405A CN 110740753 A CN110740753 A CN 110740753A
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reaction
pab
cit
val
maa
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黄长江
叶慧
姚雪静
接浩华
翟世重
房健民
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Rongchang Biopharmaceutical (yantai) Co Ltd
Remegen Co Ltd
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Rongchang Biopharmaceutical (yantai) Co Ltd
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Abstract

本发明涉及一种抗体药物偶联物中间体的制备工艺，与现有技术相比，本发明提供的抗体药物偶联物中间体的制备工艺由于药物部分是在最后一步参与的反应，显著地降低了药物部分,例如MMAD/MMAE或MMAF等投料的损耗，有效地降低了生产成本，提高了生产效益。另外，本发明提供的工艺简单、对环境友好，适于工业化大规模推广。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201980002405.XA 2018-05-21 2019-05-20 一种抗体药物偶联物中间体的制备工艺 Pending CN110740753A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018104878564 2018-05-21
CN201810487856.4A CN110507824A (zh) 2018-05-21 2018-05-21 一种抗间皮素抗体及其抗体药物缀合物
PCT/CN2019/087641 WO2019223653A1 (zh) 2018-05-21 2019-05-20 一种抗体药物偶联物中间体的制备工艺

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CN110740753A true CN110740753A (zh) 2020-01-31

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CN201810487856.4A Withdrawn CN110507824A (zh) 2018-05-21 2018-05-21 一种抗间皮素抗体及其抗体药物缀合物
CN201980002416.8A Active CN110740754B (zh) 2018-05-21 2019-05-15 一种抗间皮素抗体及其抗体药物缀合物
CN201980002405.XA Pending CN110740753A (zh) 2018-05-21 2019-05-20 一种抗体药物偶联物中间体的制备工艺

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EP (2) EP3695852A4 (zh)
JP (3) JP2021523874A (zh)
KR (3) KR20200120728A (zh)
CN (3) CN110507824A (zh)
AU (2) AU2019272250B2 (zh)
BR (2) BR112020014380A2 (zh)
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RU (2) RU2747995C1 (zh)
SG (2) SG11202011159QA (zh)
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US11717575B2 (en) 2019-05-20 2023-08-08 Mabplex International Co., Ltd. One-pot process for preparing intermediate of antibody-drug conjugate
CN111560072B (zh) * 2020-07-16 2020-12-11 上海恒润达生生物科技有限公司 抗人msln抗体以及靶向msln的免疫效应细胞
EP4129335A4 (en) 2020-09-01 2024-04-24 Remegen Co Ltd ANTI C-MET DRUG-ANTIBODY CONJUGATE AND ITS APPLICATIONS
JP2023169444A (ja) * 2020-10-01 2023-11-30 株式会社Epsilon Molecular Engineering 標的タンパク質と結合し得る架橋ペプチド、当該架橋ペプチドの作製方法、及び当該架橋ペプチドを有効成分とする医薬組成物
KR20230165255A (ko) * 2021-03-31 2023-12-05 레메젠 코, 리미티드 항체 약물 접합체 중간체의 제조 및 정제 방법
WO2022237666A1 (zh) 2021-05-08 2022-11-17 荣昌生物制药(烟台)股份有限公司 一种抗Claudin18.2抗体及其抗体药物偶联物
WO2022262859A1 (zh) * 2021-06-18 2022-12-22 江苏先声药业有限公司 抗人msln人源化抗体及其应用
CN116410332A (zh) * 2021-12-29 2023-07-11 上海细胞治疗集团有限公司 抗间皮素纳米抗体嵌合抗原受体及其应用
WO2023157989A1 (ko) * 2022-02-17 2023-08-24 주식회사 노벨티노빌리티 항체-약물 접합체
CN117843793A (zh) * 2024-03-07 2024-04-09 深圳真实生物医药科技有限公司 抗间皮素抗体、抗原结合片段及其用途

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