CN110668994A - 左旋卡维地洛盐晶型、其制备方法及应用 - Google Patents
左旋卡维地洛盐晶型、其制备方法及应用 Download PDFInfo
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- CN110668994A CN110668994A CN201911100686.0A CN201911100686A CN110668994A CN 110668994 A CN110668994 A CN 110668994A CN 201911100686 A CN201911100686 A CN 201911100686A CN 110668994 A CN110668994 A CN 110668994A
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- carvedilol
- levo
- levocarvedilol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
水中溶解度(mg/L) | |
左旋卡维地洛 | 0.5 |
左旋卡维地洛磷酸盐 | 4425.1 |
左旋卡维地洛盐酸盐 | 1620.0 |
左旋卡维地洛硫酸盐 | 324.6 |
左旋卡维地洛富马酸盐 | 349.9 |
左旋卡维地洛酒石酸盐 | 660.1 |
Claims (10)
Priority Applications (1)
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CN201911100686.0A CN110668994A (zh) | 2019-11-12 | 2019-11-12 | 左旋卡维地洛盐晶型、其制备方法及应用 |
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CN201911100686.0A CN110668994A (zh) | 2019-11-12 | 2019-11-12 | 左旋卡维地洛盐晶型、其制备方法及应用 |
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Publication Number | Publication Date |
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CN110668994A true CN110668994A (zh) | 2020-01-10 |
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CN201911100686.0A Pending CN110668994A (zh) | 2019-11-12 | 2019-11-12 | 左旋卡维地洛盐晶型、其制备方法及应用 |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998009625A1 (en) * | 1996-09-05 | 1998-03-12 | Eli Lilly And Company | SELECTIVE β3 ADRENERGIC AGONISTS |
CN101891671A (zh) * | 2010-07-26 | 2010-11-24 | 天津大学 | 一种卡维地洛磷酸二氢盐的晶体及其制备方法 |
CN102336701A (zh) * | 2010-07-26 | 2012-02-01 | 江苏恒瑞医药股份有限公司 | 硫酸卡维地洛的结晶、其制备方法及其在医药上的应用 |
CN106045900A (zh) * | 2016-07-07 | 2016-10-26 | 佛山市隆信医药科技有限公司 | 一种磷酸卡维地洛的制备方法 |
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2019
- 2019-11-12 CN CN201911100686.0A patent/CN110668994A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998009625A1 (en) * | 1996-09-05 | 1998-03-12 | Eli Lilly And Company | SELECTIVE β3 ADRENERGIC AGONISTS |
CN101891671A (zh) * | 2010-07-26 | 2010-11-24 | 天津大学 | 一种卡维地洛磷酸二氢盐的晶体及其制备方法 |
CN102336701A (zh) * | 2010-07-26 | 2012-02-01 | 江苏恒瑞医药股份有限公司 | 硫酸卡维地洛的结晶、其制备方法及其在医药上的应用 |
CN106045900A (zh) * | 2016-07-07 | 2016-10-26 | 佛山市隆信医药科技有限公司 | 一种磷酸卡维地洛的制备方法 |
Non-Patent Citations (1)
Title |
---|
FREDERICK G. VOGT ET AL.: "Isomorphism, Disorder, and Hydration in the Crystal Structures of Racemic and Single-Enantiomer Carvedilol Phosphate", 《CRYSTAL GROWTH & DESIGN》 * |
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Inventor after: Cai Zheng Inventor after: Jiang Hong Inventor after: Liu Shuwen Inventor after: Zhang Qi Inventor after: Liu Menghua Inventor after: Lv Chuantao Inventor after: Guan Jian Inventor after: Gao Yi Inventor after: Xi Xiang Ming Inventor before: Jiang Hong Inventor before: Lv Chuantao Inventor before: Liu Menghua Inventor before: Cai Zheng Inventor before: Guan Jian Inventor before: Gao Yi Inventor before: Xi Xiang Ming |
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